SEC Info - Bessemer Venture Partners II LP - ‘SC 13G/A’ on 2/12/99 re: Isis Pharmaceuticals Inc

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Bessemer Venture Partners II LP – ‘SC 13G/A’ on 2/12/99 re: Isis Pharmaceuticals Inc

As of: Friday, 2/12/99 · Accession #: 893838-99-27 · File #: 5-41771

  As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 2/12/99  Bessemer Venture Partners II LP   SC 13G/A               1:27K  Isis Pharmaceuticals Inc          Chadbourne & Par… LLP/FA

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: SC 13G/A    Amendment to Statement of Beneficial Ownership        16     53K

Document Table of Contents

Page	(sequential)	\|	(alphabetic)	Top
			Alternative Formats (Word, et al.) Certification Identification and Classification of Members of the Group Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: Notice of Dissolution of Group Ownership of Five Percent or Less of a Class Ownership of More than Five Percent on Behalf of Another Person
1	1st Page - Filing Submission
14	Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:
"	Item 5. Ownership of Five Percent or Less of a Class
"	Item 6. Ownership of More than Five Percent on Behalf of Another Person
"	Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company
"	Item 8. Identification and Classification of Members of the Group
"	Item 9. Notice of Dissolution of Group
15	Item 10. Certification

SC 13G/A 1st Page of 16 TOC ↑Top Previous Next ↓Bottom Just 1st
 
 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

 Under the Securities Exchange Act of 1934

(Amendment No. 7)*

ISIS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
(Name of Issuer)

Common Stock
--------------------------------------------------------------------------------
(Title of Class of Securities)

4643300109
--------------------------------------------------------------------------------
(CUSIP Number)

 December 31, 1998
--------------------------------------------------------------------------------
 (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule 
is filed:                                                                       

Rule 13d-1(b)         
Rule 13d-1(c)         
[X]  Rule 13d-1(d)              

*The remainder of this cover page shall be filled out for a reporting person's  
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the       
disclosures provided in a prior cover page.                                     

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of   
1934 ("Act") or otherwise subject to the liabilities of that section of the Act 
but shall be subject to all other provisions of the Act (however, see the       
Notes).                                                                         

Page 1 of 16 Pages

SC 13G/A 2nd Page of 16 TOC 1st Previous Next ↓Bottom Just 2nd
CUSIP No.    464330109              13G               Page  2   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

BESSEMER VENTURE PARTNERS II L.P. ("Bessemer II")     
13-3174238                                            
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                             (a) [X]
                                             (b) |_|
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

Delaware                                              
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      759,566 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0- shs.                  
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              759,566 shs.            
                                   ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

759,566 shs.                                          
--------------------------------------------------------------------------------
    10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

2.80%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

PN                                                    
--------------------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 2 of 16 Pages

SC 13G/A 3rd Page of 16 TOC 1st Previous Next ↓Bottom Just 3rd
CUSIP No.    464330109              13G               Page  3   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

DEER II & CO. LLC ("Deer II")*                        
13-3174240                                            
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  [X]
                                              (b)  |_|
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

Delaware                                              
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      759,566 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0- shs.                  
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              759,566 shs.            
                                 ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

759,566 shs.                                          
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

2.80%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

PN                                                    
--------------------------------------------------------------------------------

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 3 of 16 Pages

SC 13G/A 4th Page of 16 TOC 1st Previous Next ↓Bottom Just 4th
CUSIP No.    464330109              13G               Page  4   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

BESSEMER VENTURE PARTNERS III L.P. ("Bessemer III")   
11-3197697                                            
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  [X]
                                              (b)  |_|
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

Delaware                                              
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      770,124 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0- shs.                  
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              770,124 shs.            
                                 ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

                  -0- shs.
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

770,124 shs.                                          
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

2.90%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

PN                                                    
--------------------------------------------------------------------------------

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 4 of 16 Pages

SC 13G/A 5th Page of 16 TOC 1st Previous Next ↓Bottom Just 5th
CUSIP No.    464330109              13G               Page  5   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

DEER III & CO. LLC ("Deer III")*                      
11-3197696                                            
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  [X]
                                              (b)  |_|
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

Delaware                                              
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      770,124 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0- shs.                  
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              770,124 shs.            
                                 ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

                  -0- shs.
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

770,124 shs.                                          
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

2.90%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

PN                                                    
--------------------------------------------------------------------------------

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 5 of 16 Pages

SC 13G/A 6th Page of 16 TOC 1st Previous Next ↓Bottom Just 6th
CUSIP No.    464330109              13G               Page  6   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

NEILL H. BROWNSTEIN                                   
338-34-8031                                           
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                     74,073 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              74,073 shs.             
                                 ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

74,073 shs.                                           

--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.27%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
--------------------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 6 of 16 Pages

SC 13G/A 7th Page of 16 TOC 1st Previous Next ↓Bottom Just 7th
CUSIP No.    464330109              13G               Page  7   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

ROBERT H. BUESCHER                                    
491-26-2687                                           
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                    9,217 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              9,217 shs.              
                                   ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

9,217 shs.                                            
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.03%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
--------------------------------------------------------------------------------

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 7 of 16 Pages

SC 13G/A 8th Page of 16 TOC 1st Previous Next ↓Bottom Just 8th
CUSIP No.    464330109              13G               Page  8   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

WILLIAM T. BURGIN                                     
024-34-5186                                           
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      105,059 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                    ---------------------------------------------
REPORTING                    7      SOLE DISPOSITIVE POWER    
PERSON                                                      
WITH                              105,059 shs.            
                                   ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

105,059 shs.                                          
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.40%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
--------------------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 8 of 16 Pages

SC 13G/A 9th Page of 16 TOC 1st Previous Next ↓Bottom Just 9th
CUSIP No.    464330109              13G               Page  9   of   16   Pages 
     ---------                                     ---      ----

--------------------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

G. FELDA HARDYMON                                     
277-44-0815                                           
--------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
--------------------------------------------------------------------------------
3       SEC USE ONLY                                                  

--------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
--------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

                     34,545 shs.
         NUMBER OF                 ---------------------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                    ---------------------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              34,545 shs.             
                                   ---------------------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
--------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

34,545 shs.                                           
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.13%                                                 
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
--------------------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 9 of 16 Pages  

SC 13G/A 10th Page of 16 TOC 1st Previous Next ↓Bottom Just 10th
CUSIP No.    464330109              13G               Page  10   of   16   Pages
      ---------                                     ----      ----

------------ -------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

CHRISTOPHER F.O. GABRIELI                             
091-56-3659                                           
------------ -------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
------------ -------------------------------------------------------------------
3       SEC USE ONLY                                                  

------------ -------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
------------ -------------------------------------------------------------------
                    5      SOLE VOTING POWER

                      157,546 shs.
         NUMBER OF                ---------- -----------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                   ---------- -----------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              157,546 shs.            
                                  ---------- -----------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
------------ -------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

157,546 shs.                                          
------------ -------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

------------ -------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.60%                                                 
------------ -------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
------------ -------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 10 of 16 Pages 

SC 13G/A 11th Page of 16 TOC 1st Previous Next ↓Bottom Just 11th
CUSIP No.    464330109              13G               Page  11   of   16   Pages
      ---------                                     ----      ----

------------ -------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

MICHAEL I. BARACH                                     
295-44-7789                                           
------------ -------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
------------ -------------------------------------------------------------------
3       SEC USE ONLY                                                  

------------ -------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
------------ -------------------------------------------------------------------
                    5      SOLE VOTING POWER

                  589 shs.
         NUMBER OF                ---------- -----------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                   ---------- -----------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              589 shs.                
                                  ---------- -----------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
------------ -------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

589 shs.                                              
------------ -------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

------------ -------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.002%                                                
------------ -------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
------------ -------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 11 of 16 Pages 

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CUSIP No.    464330109              13G               Page  12   of   16   Pages
      ---------                                     ----      ----

------------ -------------------------------------------------------------------
1       NAME OF REPORTING PERSON                                      
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON     

DAVID J. COWAN                                        
091-62-5910                                           
------------ -------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             
                                              (a)  |_|
                                              (b)  [X]
------------ -------------------------------------------------------------------
3       SEC USE ONLY                                                  

------------ -------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION                          

U.S.A.                                                
------------ -------------------------------------------------------------------
                    5      SOLE VOTING POWER

                    1,147 shs.
         NUMBER OF                ---------- -----------------------------------
SHARES                      6      SHARED VOTING POWER      
BENEFICIALLY                                                      
OWNED BY                            -0-                       
           EACH                   ---------- -----------------------------------
REPORTING                     7      SOLE DISPOSITIVE POWER     
PERSON                                                      
WITH                              1,147 shs.              
                                  ---------- -----------------------------------
                           8      SHARED DISPOSITIVE POWER

             -0-
------------ -------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

1,147 shs.                                            
------------ -------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
SHARES*                                               

------------ -------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

0.004%                                                
------------ -------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*                                      

IN                                                    
------------ -------------------------------------------------------------------
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 12 of 16 Pages 

SC 13G/A 13th Page of 16 TOC 1st Previous Next ↓Bottom Just 13th
Item 1.                                                                         

(a)   Name of Issuer:                                                           

ISIS Pharmaceuticals, Inc.

(b)   Address of Issuer's Principal Executive Office:                           

2280 B Faraday Avenue     
 Carlsbad, California  92008

Item 2.                                                                         

        (a), (b) and (c) Name of Persons Filing, Address of Principal Business
Office and Citizenship:                                     

                This statement is filed by Bessemer Venture Partners II L.P.
and Bessemer Venture Partners III L.P. (collectively referred to as "Bessemer"),
both Delaware limited partnerships having their principal office at 1400 Old    
Country Road, Suite 407, Westbury, New York, 11590. Bessemer's principal        
business is making venture capital investments for its own account and is       
carried on at its principal office.                                             

                 This statement is also filed by Deer II & Co. LLC, a Delaware
limited liability company whose members are Neill H. Brownstein*, Robert H.     
Buescher, William T. Burgin, G. Felda Hardymon and Christopher Gabrieli, and by 
Deer III & Co. LLC, a Delaware limited liability company whose members are Neill
Brownstein*, Robert H. Buescher, William T. Burgin, G. Felda Hardymon,          
Christopher F.O. Gabrieli, Michael I. Barach** and David J. Cowan. All of such  
individuals are United States citizens. This statement is also filed by each of 
such individuals. Deer II & Co. LLC and Deer III & Co. LLC are, respectively,   
the General Partners of Bessemer Venture Partners II L.P. and Bessemer Venture  
Partners III L.P. and have their principal offices at the same address as       
Bessemer. The principal business of Deer II & Co. LLC and Deer III & Co. LLC is 
making venture capital investments for the account of Bessemer and is carried on
at their principal offices, at 535 Middlefield Road, Suite 245, Menlo Park,     
California 94025 and at 83 Walnut Street, Wellesley Hills, Massachusetts        
02181-2101. Mr. Brownstein's and Mr. Cowan's principal business address is the  
Menlo Park address. Mr. Buescher's principal business address is the principal  
office of Bessemer. Mr. Burgin's, Mr. Hardymon's, Mr. Gabrieli's and Mr.        
Barach's principal business address is the Wellesley Hills address.             

*  As of January 1, 1995 Mr. Brownstein became a special member of              
Deer II and Deer III with no power to participate in the management of its      
affairs.                                                                        

** As of August 1, 1996, Mr. Barach became a special member of Deer III with no 
power to participate in the management of its affairs.                          

(d)   Title of Class of Securities:                                             

Common Stock              

(e)   CUSIP Number:                                                             

4643300109                

Page 13 of 16 Pages 

SC 13G/A 14th Page of 16 TOC 1st Previous Next ↓Bottom Just 14th
Item 3.  If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or   
(c), check whether the person filing is a:                    

Not applicable                              

Item 4.  Ownership as of December 31, 1995                                      

             Items 5 through 9 of Pages 2 through 12 of this Statement
incorporated herein by reference.                                               

Item 5.  Ownership of Five Percent or Less of a Class                           

Not applicable.                             

Item 6.  Ownership of More than Five Percent on Behalf of Another Person        

Not applicable.                             

Item 7.  Identification and Classification of the Subsidiary Which Acquired the 
Security Being Reported on By the Parent Holding Company      

Not applicable.                             

Item 8.  Identification and Classification of Members of the Group              

See the answer to Item 2(a), (b) and (c).   

Item 9.  Notice of Dissolution of Group                                         

Not applicable.                             

Page 14 of 16 Pages 

SC 13G/A 15th Page of 16 TOC 1st Previous Next ↓Bottom Just 15th
Item 10.  Certification                                                         

Not applicable.                             

SIGNATURES

                 After reasonable inquiry and to the best of our knowledge and
belief, we certify that the information set forth in this statement is true,    
complete and correct.                                                           

Dated:  February 10, 1999                                                       

                   BESSEMER VENTURE PARTNERS II L.P.

                            By:     Deer II & Co. LLC, General Partner

                By:     /s/ Robert H. Buescher
                                   -----------------------------------------
                             Robert H. Buescher, Manager

   DEER II & Co. LLC

                By:     /s/ Robert H. Buescher
                                   -----------------------------------------
                             Robert H. Buescher, Manager

                    BESSEMER VENTURE PARTNERS III L.P.

                             By:     Deer III & Co. LLC, General Partner

                By:     /s/ Robert H. Buescher
                                   -----------------------------------------
                             Robert H. Buescher, Manager

    DEER III & Co. LLC

                By:     /s/ Robert H. Buescher
                                   -----------------------------------------
                             Robert H. Buescher, Manager

     NEILL H. BROWNSTEIN

        By:                  *
                                   -----------------------------------------
                                      Robert H. Buescher, Attorney-in-Fact

Page 15 of 16 Pages 

SC 13G/A Last Page of 16 TOC 1st Previous Next ↓Bottom Just 16th
   WILLIAM T. BURGIN

        By:                  *
                                   -----------------------------------------
                                      Robert H. Buescher, Attorney-in-Fact

   G. FELDA HARDYMON

              By:                        *
                                   -----------------------------------------
                                      Robert H. Buescher, Attorney-in-Fact

           CHRISTOPHER F.O. GABRIELI

        By:                  *
                                   -----------------------------------------
                                      Robert H. Buescher, Attorney-in-Fact

   MICHAEL I. BARACH

        By:                  *
                                   -----------------------------------------
                                      Robert H. Buescher, Attorney-in-Fact

                        /s/ Robert H. Buescher
                                   -----------------------------------------
                                 Robert H. Buescher for himself and as
                                  Attorney-in-Fact for the above parties
                              having an asterisk (*) above their
          signature line

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Dates Referenced Herein and Documents Incorporated by Reference

		Referenced-On Page
This ‘SC 13G/A’ Filing	Date	First	Last	Other Filings

Filed on:	2/12/99			SC 13G, SC 13G/A
	2/10/99	15
	12/31/98	1		10-K405, 10-K405/A
	8/1/96	13
	12/31/95	14
	1/1/95	13
				List all Filings

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Filing Submission 0000893838-99-000027 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Bessemer Venture Partners II LP – ‘SC 13G/A’ on 2/12/99 re: Isis Pharmaceuticals Inc

As of: Friday, 2/12/99 · Accession #: 893838-99-27 · File #: 5-41771

Previous ‘SC 13G’: ‘SC 13G/A’ on 2/12/99 · Next & Latest: ‘SC 13G/A’ on 2/14/00

Amendment to Statement of Beneficial Ownership — Schedule 13GFiling Table of Contents

Document Table of Contents

Dates Referenced Herein and Documents Incorporated by Reference

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents