SEC Info - Bessemer Venture Partners II LP - ‘SC 13G/A’ on 2/14/00 re: Isis Pharmaceuticals Inc

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Bessemer Venture Partners II LP – ‘SC 13G/A’ on 2/14/00 re: Isis Pharmaceuticals Inc

On: Monday, 2/14/00 · Accession #: 893838-0-37 · File #: 5-41771

  As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 2/14/00  Bessemer Venture Partners II LP   SC 13G/A               1:28K  Isis Pharmaceuticals Inc          Chadbourne & Par… LLP/FA

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: SC 13G/A    Amendment No. 8                                       16     54K

Document Table of Contents

Page	(sequential)	\|	(alphabetic)	Top
			Alternative Formats (Word, et al.) Certification Identification and Classification of Members of the Group Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: Notice of Dissolution of Group Ownership of Five Percent or Less of a Class Ownership of More than Five Percent on Behalf of Another Person
1	1st Page - Filing Submission
14	Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:
"	Item 5. Ownership of Five Percent or Less of a Class
"	Item 6. Ownership of More than Five Percent on Behalf of Another Person
"	Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company
"	Item 8. Identification and Classification of Members of the Group
"	Item 9. Notice of Dissolution of Group
15	Item 10. Certification

SC 13G/A 1st Page of 16 TOC ↑Top Previous Next ↓Bottom Just 1st
 
UNITED STATES 
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

 Under the Securities Exchange Act of 1934

(Amendment No. 8)*

ISIS PHARMACEUTICALS, INC.
------------------------------------------------------------------------------- 
(Name of Issuer)

Common Stock
------------------------------------------------------------------------------- 
(Title of Class of Securities)

 464330109
------------------------------------------------------------------------------- 
(CUSIP Number)

 December 31, 1999
------------------------------------------------------------------------------- 
 (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule 
is filed:                                                                       

|_| Rule 13d-1(b)             
|_| Rule 13d-1(c)             
|X| Rule 13d-1(d)             

*The remainder of this cover page shall be filled out for a reporting person's  
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the       
disclosures provided in a prior cover page.                                     

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of   
1934 ("Act") or otherwise subject to the liabilities of that section of the Act 
but shall be subject to all other provisions of the Act (however, see the       
Notes).                                                                         

Page 1 of 16 pages

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-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 2 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   

BESSEMER VENTURE PARTNERS II L.P. ("Bessemer II")   
13-3174238                                          
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) |X|
                                                             (b) | |

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                            
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                        759,566 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           759,566 shs.         
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

759,566 shs.                                        
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

2.5%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

PN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 2 of 16 pages

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-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 3 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
DEER II & CO. LLC ("Deer II")*                      
13-3174240                                          
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) |X|
                                                             (b) | |

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                            
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                        759,566 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           759,566 shs.         
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

759,566 shs.                                        
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

2.5%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

PN                                                  
------------- ----------------------------------------------------------------- 
*The shares reported on this page are the same as those reported on page 2 as   
Deer II & Co. LLC is the General Partner of Bessemer II.                        

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 3 of 16 pages

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-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 4 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   

BESSEMER VENTURE PARTNERS III L.P. ("Bessemer III") 
11-3197697                                          
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) |X|
                                                             (b) | |

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                            
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                        486,464 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0- shs.              
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           486,464 shs.         
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

                    -0- shs.
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

486,464 shs.                                        
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

1.6%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

PN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 4 of 16 pages

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-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 5 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
DEER III & CO. LLC ("Deer III")*                    
11-3197696                                          
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) |X|
                                                             (b) | |

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                            
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                        486,464 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0- shs.              
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           486,464 shs.         
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

                    -0- shs.
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

486,464 shs.                                        
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

1.6%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

PN                                                  
------------- ----------------------------------------------------------------- 
*The shares reported on this page are the same as those reported on page 4 as   
Deer III & Co. LLC is the General Partner of Bessemer III.                      

 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 5 of 16 pages

SC 13G/A 6th Page of 16 TOC 1st Previous Next ↓Bottom Just 6th
-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 6 of 16 Pages
-------------------                                           ------------------

------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   

NEILL H. BROWNSTEIN                                 
338-34-8031                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

               -0-
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           -0-                  
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

-0-                                                 
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

-0-                                                 
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 6 of 16 pages

SC 13G/A 7th Page of 16 TOC 1st Previous Next ↓Bottom Just 7th
-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 7 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
ROBERT H. BUESCHER                                  
491-26-2687                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                      8,924 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           8,924 shs.           
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

8,924 shs.                                          
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.03%                                               
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 7 of 16 pages

SC 13G/A 8th Page of 16 TOC 1st Previous Next ↓Bottom Just 8th
-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 8 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
WILLIAM T. BURGIN                                   
024-34-5186                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                       50,000 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           50,000 shs.          
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

50,000 shs.                                         
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.17%                                               
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 8 of 16 pages

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-------------------                                           ------------------
CUSIP No. 464330109                 13G                       Page 9 of 16 Pages
-------------------                                           ------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
G. FELDA HARDYMON                                   
277-44-0815                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                       33,666 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           33,666 shs.          
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

33,666 shs.                                         
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.11%                                               
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

Page 9 of 16 pages

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-------------------                                          -------------------
CUSIP No. 464330109                 13G                      Page 10 of 16 Pages
-------------------                                          -------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
CHRISTOPHER F. O. GABRIELI                          
091-56-3659                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                        111,364 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           111,364 shs.         
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

111,364 shs.                                        
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.4%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

 Page 10 of 16 pages

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-------------------                                          -------------------
CUSIP No. 464330109                 13G                      Page 11 of 16 Pages
-------------------                                          -------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
MICHAEL I. BARACH                                   
295-44-7789                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

                    140 shs.
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           140 shs.             
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

140 shs.                                            
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.0%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

 Page 11 of 16 pages

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-------------------                                          -------------------
CUSIP No. 464330109                 13G                      Page 12 of 16 Pages
-------------------                                          -------------------
------------- ----------------------------------------------------------------- 
1        NAME OF REPORTING PERSON                                     
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON   
DAVID J. COWAN                                      
091-62-5910                                         
------------- ----------------------------------------------------------------- 
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                             (a) | |
                                                             (b) |X|

------------- ----------------------------------------------------------------- 
3        SEC USE ONLY                                                 

------------- ----------------------------------------------------------------- 
4        CITIZENSHIP OR PLACE OF ORGANIZATION                         

U.S.A.                                              
---------------------------------- ---------- --------------------------------- 
                      5      SOLE VOTING POWER

               -0-
NUMBER OF                                               
                                  ---------- ---------------------------------
SHARES                    6      SHARED VOTING POWER  
BENEFICIALLY                                                
OWNED BY                          -0-                   
                                  ---------- ---------------------------------
  EACH                     7      SOLE DISPOSITIVE POWER
REPORTING                                               
PERSON                           -0-                  
                                  ---------- ---------------------------------
    WITH                     8      SHARED DISPOSITIVE POWER

               -0-
---------------------------------- ---------- --------------------------------- 
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

-0-                                                 
------------- ----------------------------------------------------------------- 
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES*                                                  | |

------------- ----------------------------------------------------------------- 
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9              

0.0%                                                
------------- ----------------------------------------------------------------- 
12       TYPE OF REPORTING PERSON*                                    

IN                                                  
------------- ----------------------------------------------------------------- 
 *SEE INSTRUCTIONS BEFORE FILLING OUT!

 Page 12 of 16 pages

SC 13G/A 13th Page of 16 TOC 1st Previous Next ↓Bottom Just 13th
Item 1.                                                                         

(a)      Name of Issuer:                                                        

ISIS Pharmaceuticals, Inc.

(b)      Address of Issuer's Principal Executive Office:                        

2280 B Faraday Avenue     
 Carlsbad, California  92008

Item 2.                                                                         

        (a), (b) and (c) Name of Persons Filing, Address of Principal Business
                         -----------------------------------------------------
Office and Citizenship:                                       
----------------------                                        
                This statement is filed by Bessemer Venture Partners II L.P.
and Bessemer Venture Partners III L.P. (collectively referred to as "Bessemer"),
both Delaware limited partnerships having their principal office at 1400 Old    
Country Road, Suite 407, Westbury, New York, 11590. Bessemer's principal        
business is making venture capital investments for its own account and is       
carried on at its principal office.                                             

                   This statement is also filed by Deer II & Co. LLC, a Delaware
limited liability company whose members are Neill H. Brownstein*, Robert H.     
Buescher, William T. Burgin, G. Felda Hardymon and Christopher F. O. Gabrieli,  
and by Deer III & Co. LLC, a Delaware limited liability company whose members   
are Neill H. Brownstein*, Robert H. Buescher, William T. Burgin, G. Felda       
Hardymon, Christopher F. O. Gabrieli, Michael I. Barach** and David J. Cowan.   
All of such individuals are United States citizens. This statement is also filed
by each of such individuals. Deer II & Co. LLC and Deer III & Co. LLC are,      
respectively, the General Partners of Bessemer Venture Partners II L.P. and     
Bessemer Venture Partners III L.P. and have their principal offices at the same 
address as Bessemer. The principal business of Deer II & Co. LLC and Deer III & 
Co. LLC is making venture capital investments for the account of Bessemer and is
carried on at their principal offices, at 535 Middlefield Road, Suite 245, Menlo
Park, California 94025 and at 83 Walnut Street, Wellesley Hills, Massachusetts  
02181-2101. Mr. Brownstein's and Mr. Cowan's principal business address is the  
Menlo Park address. Mr. Buescher's principal business address is the principal  
office of Bessemer. Mr. Burgin's, Mr. Hardymon's, Mr. Gabrieli's and Mr.        
Barach's principal business address is the Wellesley Hills address.             

*As of January 1, 1995, Mr. Brownstein became a special member of Deer II and   
Deer III with no power to participate in the management of their affairs.       
**As of August 1, 1996, Mr. Barach became a special member of Deer III with no  
power to participate in the management of its affairs.                          

(d)      Title of Class of Securities:                                          

Common Stock              

(e)      CUSIP Number:                                                          

464330109                 

Page 13 of 16 pages 

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Item 3.  If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or   
(c), check whether the person filing is a:                    

Not applicable.                             

Item 4.  Ownership as of December 31, 1999                                      

             Items 5 through 9 of Pages 2 through 12 of this Statement
incorporated herein by reference.                                               

Item 5.  Ownership of Five Percent or Less of a Class                           

                  If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the beneficial owner of   
more than five percent of the class securities, check the following |X|.        

Item 6.  Ownership of More than Five Percent on Behalf of Another Person        

Not applicable.                             

Item 7.  Identification and Classification of the Subsidiary Which Acquired the 
Security Being Reported on By the Parent Holding Company      

Not applicable.                             

Item 8.  Identification and Classification of Members of the Group              

See the answer to Item 2(a), (b) and (c).   

Item 9.  Notice of Dissolution of Group                                         

Not applicable.                             

 Page 14 of 16 pages

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Item 10.  Certification                                                         

Not applicable.                             

SIGNATURES

                 After reasonable inquiry and to the best of our knowledge and
belief, we certify that the information set forth in this statement is true,    
complete and correct.                                                           

Dated: February 14, 2000                                                        

 BESSEMER VENTURE PARTNERS II L.P.

      By: Deer II & Co. LLC, General Partner

By: /s/ Robert H. Buescher      
          ------------------------------------
 Robert H. Buescher, Manager

DEER II & Co. LLC               

By: /s/ Robert H. Buescher      
          ------------------------------------
 Robert H. Buescher, Manager

  BESSEMER VENTURE PARTNERS III L.P.

       By: Deer III & Co. LLC, General Partner

By: /s/ Robert H. Buescher      
          ------------------------------------
 Robert H. Buescher, Manager

DEER III & Co. LLC              

By: /s/ Robert H. Buescher      
          ------------------------------------
   Robert H. Buescher, Manager

NEILL H. BROWNSTEIN             

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

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WILLIAM T. BURGIN               

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

G. FELDA HARDYMON               

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

CHRISTOPHER F.O. GABRIELI       

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

MICHAEL I. BARACH               

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

DAVID J. COWAN                  

By:                 *           
          ------------------------------------
          Robert H. Buescher, Attorney-in-Fact

/s/ Robert H. Buescher        
        ----------------------------------------
     Robert H. Buescher for himself and as
      Attorney-in-Fact for the above parties
  having an asterisk (*) above their
signature line                  

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Dates Referenced Herein and Documents Incorporated by Reference

		Referenced-On Page
This ‘SC 13G/A’ Filing	Date	First	Last	Other Filings

Filed on:	2/14/00	15
	12/31/99	1	14	10-K405, ARS
	8/1/96	13
	1/1/95	13
				List all Filings

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Filing Submission 0000893838-00-000037 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Bessemer Venture Partners II LP – ‘SC 13G/A’ on 2/14/00 re: Isis Pharmaceuticals Inc

On: Monday, 2/14/00 · Accession #: 893838-0-37 · File #: 5-41771

Previous ‘SC 13G’: ‘SC 13G/A’ on 2/12/99 · Latest ‘SC 13G’: This Filing

Amendment to Statement of Beneficial Ownership — Schedule 13GFiling Table of Contents

Document Table of Contents

Dates Referenced Herein and Documents Incorporated by Reference

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents