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<ownershipDocument> |
| <schemaVersion> X0306 </schemaVersion> |
| <documentType> 4 </documentType> |
| <periodOfReport> 2020-07-08 </periodOfReport> |
| <notSubjectToSection16> 0 </notSubjectToSection16> |
| <issuer> |
| | <issuerCik> 0001785173 </issuerCik> |
| | <issuerName> 89bio, Inc. </issuerName> |
| | <issuerTradingSymbol> ETNB </issuerTradingSymbol> |
| | </issuer> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001346824 </rptOwnerCik> |
| | | <rptOwnerName> RA CAPITAL MANAGEMENT, L.P. </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> 200 BERKELEY STREET, 18TH FLOOR </rptOwnerStreet1> |
| | | <rptOwnerStreet2></rptOwnerStreet2> |
| | | <rptOwnerCity> BOSTON </rptOwnerCity> |
| | | <rptOwnerState> MA </rptOwnerState> |
| | | <rptOwnerZipCode> 02116 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 1 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 1 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle></officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001315082 </rptOwnerCik> |
| | | <rptOwnerName> RA Capital Healthcare Fund LP </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O RA CAPITAL MANAGEMENT, L.P. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 200 BERKELEY STREET, 18TH FLOOR </rptOwnerStreet2> |
| | | <rptOwnerCity> BOSTON </rptOwnerCity> |
| | | <rptOwnerState> MA </rptOwnerState> |
| | | <rptOwnerZipCode> 02116 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 0 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 1 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle></officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001384859 </rptOwnerCik> |
| | | <rptOwnerName> Kolchinsky Peter </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O RA CAPITAL MANAGEMENT, L.P. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 200 BERKELEY STREET, 18TH FLOOR </rptOwnerStreet2> |
| | | <rptOwnerCity> BOSTON </rptOwnerCity> |
| | | <rptOwnerState> MA </rptOwnerState> |
| | | <rptOwnerZipCode> 02116 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 0 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 1 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle></officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001619841 </rptOwnerCik> |
| | | <rptOwnerName> Shah Rajeev M. </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O RA CAPITAL MANAGEMENT, L.P. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 200 BERKELEY STREET, 18TH FLOOR </rptOwnerStreet2> |
| | | <rptOwnerCity> BOSTON </rptOwnerCity> |
| | | <rptOwnerState> MA </rptOwnerState> |
| | | <rptOwnerZipCode> 02116 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 0 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 1 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle></officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <nonDerivativeTable> |
| | <nonDerivativeTransaction> |
| | | <securityTitle> |
| <value> Common Stock </value> |
| </securityTitle> |
| | | <transactionDate> |
| <value> 2020-07-08 </value> |
| </transactionDate> |
| | | <deemedExecutionDate></deemedExecutionDate> |
| | | <transactionCoding> |
| <transactionFormType> 4 </transactionFormType> |
| <transactionCode> P </transactionCode> |
| <equitySwapInvolved> 0 </equitySwapInvolved> |
| </transactionCoding> |
| | | <transactionTimeliness></transactionTimeliness> |
| | | <transactionAmounts> |
| <transactionShares> |
| <value> 275000 </value> |
| </transactionShares> |
| <transactionPricePerShare> |
| <value> 27.50 </value> |
| </transactionPricePerShare> |
| <transactionAcquiredDisposedCode> |
| <value> A </value> |
| </transactionAcquiredDisposedCode> |
| </transactionAmounts> |
| | | <postTransactionAmounts> |
| <sharesOwnedFollowingTransaction> |
| <value> 3436214 </value> |
| <footnoteId id="F1"/> |
| </sharesOwnedFollowingTransaction> |
| </postTransactionAmounts> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> I </value> |
| </directOrIndirectOwnership> |
| <natureOfOwnership> |
| <value> See footnote </value> |
| <footnoteId id="F2"/> |
| <footnoteId id="F3"/> |
| <footnoteId id="F4"/> |
| </natureOfOwnership> |
| </ownershipNature> |
| | | </nonDerivativeTransaction> |
| | </nonDerivativeTable> |
| <footnotes> |
| | <footnote id="F1"> These securities include 2,591,192 shares held by RA Capital Healthcare Fund, L.P. (the "Fund"), 509,658 shares held by a separately managed account ("the Account"), and 335,364 shares held by RA Capital Nexus Fund, L.P. ("the Nexus Fund"). </footnote> |
| | <footnote id="F2"> RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, the Account, and the Nexus Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. </footnote> |
| | <footnote id="F3"> The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah may be deemed indirect beneficial owners of the reported securities for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the "Act"). They disclaim beneficial ownership of any of the reported securities for the purpose of determining whether they are subject to Section 16 of the Act, however, in reliance on Rule 16a-1(a)(1)(v) and (vii). To the extent that they might be deemed subject to Section 16, they disclaim beneficial ownership of securities held by the Fund or the Nexus Fund for purposes of Rule 16a-1(a)(2), except to the extent of their pecuniary interest therein, and disclaim any pecuniary interest in securities held in the Account for purposes of Rule 16a-1(a)(2). </footnote> |
| | <footnote id="F4"> The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim any obligation to file reports under Section 16 other than as a director by deputization. </footnote> |
| | </footnotes> |
| <ownerSignature> |
| | <signatureName> /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. </signatureName> |
| | <signatureDate> 2020-07-10 </signatureDate> |
| | </ownerSignature> |
| <ownerSignature> |
| | <signatureName> /s/ Peter Kolchinsky, Manager of RA Capital Healthcare GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. </signatureName> |
| | <signatureDate> 2020-07-10 </signatureDate> |
| | </ownerSignature> |
| <ownerSignature> |
| | <signatureName> /s/ Peter Kolchinsky, individually </signatureName> |
| | <signatureDate> 2020-07-10 </signatureDate> |
| | </ownerSignature> |
| <ownerSignature> |
| | <signatureName> /s/ Rajeev Shah, individually </signatureName> |
| | <signatureDate> 2020-07-10 </signatureDate> |
| | </ownerSignature> |
| </ownershipDocument> |