Note: In January 2023, the SEC changed the meaning of Market Value to be $s instead of $1000s. This was unwise, because many Filers have not noticed
the change and are filing incorrect data. For consistency across our site, we’re adjusting Market Values the best we can and still showing them in $1000s.
| Security | Market Valueª | Shares or Principal | Investment
Discretion | Other
Managersº | Voting Authority |
|---|
| Issuer Name | Issue Class | Opt. | CUSIP/CINS | $1000s | Weight | Amount | S/P | Price | Sole | Shared | None |
|---|
 | | | | | | | | | ↓List | (S/P Amounts or For All) |
|---|
|
| 10X GENOMICS INC | CL A COM | – | 88025U·10·9 | 16,405,961 | 0.25% | 293,173 | Sh. | 55,960.00 | Defined | #2 | Sole | – | – |
| 89BIO INC | COM | – | 282559·10·3 | 225,634 | 0.00% | 20,200 | Sh. | 11,170.00 | Defined | #2 | Sole | – | – |
| ABBOTT LABS | COM | – | 002824·10·0 | 169,029,656 | 2.59% | 1,535,656 | Sh. | 110,070.00 | Defined | #2 | Sole | – | – |
| ABBVIE INC | COM | – | 00287Y·10·9 | 1,042,483 | 0.02% | 6,727 | Sh. | 154,969.97 | Defined | #2 | Sole | – | – |
| ACCOLADE INC | COM | – | 00437E·10·2 | 7,318,882 | 0.11% | 609,399 | Sh. | 12,010.00 | Defined | #2 | Sole | – | – |
| ACCOLADE INC | COM | – | 00437E·10·2 | 46,815,040 | 0.72% | 3,898,005 | Sh. | 12,010.00 | Defined | #3 | Sole | – | – |
| AGILENT TECHNOLOGIES INC | COM | – | 00846U·10·1 | 50,468 | 0.00% | 363 | Sh. | 139,030.30 | Defined | #2 | Sole | – | – |
| AGIOS PHARMACEUTICALS INC | COM | – | 00847X·10·4 | 244,970 | 0.00% | 11,000 | Sh. | 22,270.00 | Defined | #2 | Sole | – | – |
| AGIOS PHARMACEUTICALS INC | COM | – | 00847X·10·4 | 89,080,000 | 1.36% | 4,000,000 | Sh. | 22,270.00 | Defined | #1, 2 | Sole | – | – |
| ALIGN TECHNOLOGY INC | COM | – | 016255·10·1 | 43,677,518 | 0.67% | 159,407 | Sh. | 274,000.00 | Defined | #2 | Sole | – | – |
| ALKERMES PLC | SHS | – | G01767·10·5 | 1,445,587 | 0.02% | 52,112 | Sh. | 27,740.00 | Defined | #2 | Sole | – | – |
| ALNYLAM PHARMACEUTICALS INC | COM | – | 02043Q·10·7 | 4,903,541 | 0.08% | 25,618 | Sh. | 191,409.99 | Defined | #2 | Sole | – | – |
| ALNYLAM PHARMACEUTICALS INC | COM | – | 02043Q·10·7 | 164,555,177 | 2.52% | 859,700 | Sh. | 191,410.00 | Defined | #1, 2 | Sole | – | – |
| ALPHABET INC | CAP STK CL C | – | 02079K·10·7 | 845,580 | 0.01% | 6,000 | Sh. | 140,930.00 | Defined | #2 | Sole | – | – |
| AMGEN INC | COM | – | 031162·10·0 | 9,851,724 | 0.15% | 34,205 | Sh. | 288,020.00 | Defined | #2 | Sole | – | – |
| AMNEAL PHARMACEUTICALS INC | COM STK CL A | – | 03168L·10·5 | 154,603 | 0.00% | 25,470 | Sh. | 6,070.00 | Defined | #2 | Sole | – | – |
| APELLIS PHARMACEUTICALS INC | COM | – | 03753U·10·6 | 1,203,186 | 0.02% | 20,100 | Sh. | 59,860.00 | Defined | #2 | Sole | – | – |
| APELLIS PHARMACEUTICALS INC | COM | – | 03753U·10·6 | 47,989,762 | 0.73% | 801,700 | Sh. | 59,860.00 | Defined | #3 | Sole | – | – |
| ARGENX SE | SPONSORED ADR | – | 04016X·10·1 | 16,820,284 | 0.26% | 44,208 | Sh. | 380,480.55 | Defined | #2 | Sole | – | – |
| ARGENX SE | SPONSORED ADR | – | 04016X·10·1 | 313,854,750 | 4.80% | 825,000 | Sh. | 380,430.00 | Defined | #1, 2 | Sole | – | – |
| ARVINAS INC | COM | – | 04335A·10·5 | 543,312 | 0.01% | 13,200 | Sh. | 41,160.00 | Defined | #2 | Sole | – | – |
| ARVINAS INC | COM | – | 04335A·10·5 | 102,674,896 | 1.57% | 2,494,531 | Sh. | 41,160.00 | Defined | #1, 2 | Sole | – | – |
| ASTRAZENECA PLC | SPONSORED ADR | – | 046353·10·8 | 3,475,260 | 0.05% | 51,600 | Sh. | 67,350.00 | Defined | #2 | Sole | – | – |
| ATRICURE INC | COM | – | 04963C·20·9 | 29,190,244 | 0.45% | 817,883 | Sh. | 35,690.00 | Defined | #3 | Sole | – | – |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | – | 05280R·10·0 | 322,000 | 0.00% | 50,000 | Sh. | 6,440.00 | Defined | #2 | Sole | – | – |
| AXONICS INC | COM | – | 05465P·10·1 | 50,297,771 | 0.77% | 808,256 | Sh. | 62,230.00 | Defined | #2 | Sole | – | – |
| AXONICS INC | COM | – | 05465P·10·1 | 63,780,087 | 0.98% | 1,024,909 | Sh. | 62,230.00 | Defined | #3 | Sole | – | – |
| AXSOME THERAPEUTICS INC | COM | – | 05464T·10·4 | 50,569,257 | 0.77% | 635,372 | Sh. | 79,590.00 | Defined | #3 | Sole | – | – |
| BEAM THERAPEUTICS INC | COM | – | 07373V·10·5 | 46,274 | 0.00% | 1,700 | Sh. | 27,220.00 | Defined | #2 | Sole | – | – |
| BEAM THERAPEUTICS INC | COM | – | 07373V·10·5 | 18,866,754 | 0.29% | 693,121 | Sh. | 27,220.00 | Defined | #1, 2 | Sole | – | – |
| BECTON DICKINSON & CO | COM | – | 075887·10·9 | 94,622,620 | 1.45% | 388,068 | Sh. | 243,830.00 | Defined | #2 | Sole | – | – |
| BEIGENE LTD | SPONSORED ADR | – | 07725L·10·2 | 5,211,752 | 0.08% | 28,600 | Sh. | 182,229.09 | Defined | #2 | Sole | – | – |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | – | 088786·10·8 | 361,600 | 0.01% | 20,000 | Sh. | 18,080.00 | Defined | #2 | Sole | – | – |
| BIO RAD LABS INC | CL A | – | 090572·20·7 | 45,574,955 | 0.70% | 141,147 | Sh. | 322,890.00 | Defined | #3 | Sole | – | – |
| BIOGEN INC | COM | – | 09062X·10·3 | 2,195,663 | 0.03% | 8,485 | Sh. | 258,769.95 | Defined | #2 | Sole | – | – |
| BIOHAVEN LTD | COM | – | G1110E·10·7 | 46,010,000 | 0.70% | 1,075,000 | Sh. | 42,800.00 | Defined | #1, 2 | Sole | – | – |
| BIOMARIN PHARMACEUTICAL INC | COM | – | 09061G·10·1 | 31,411,322 | 0.48% | 325,776 | Sh. | 96,420.00 | Defined | #2 | Sole | – | – |
| BIOMEA FUSION INC | COM | – | 09077A·10·6 | 363,000 | 0.01% | 25,000 | Sh. | 14,520.00 | Defined | #2 | Sole | – | – |
| BLACK DIAMOND THERAPEUTICS I | COM | – | 09203E·10·5 | 50,580 | 0.00% | 18,000 | Sh. | 2,810.00 | Defined | #2 | Sole | – | – |
| BLACK DIAMOND THERAPEUTICS I | COM | – | 09203E·10·5 | 23,935,128 | 0.37% | 8,517,839 | Sh. | 2,810.00 | Defined | #1, 2 | Sole | – | – |
| BOSTON SCIENTIFIC CORP | COM | – | 101137·10·7 | 183,292,559 | 2.80% | 3,170,603 | Sh. | 57,810.00 | Defined | #2 | Sole | – | – |
| BRIDGEBIO PHARMA INC | COM | – | 10806X·10·2 | 1,344,321 | 0.02% | 33,300 | Sh. | 40,370.00 | Defined | #2 | Sole | – | – |
| C4 THERAPEUTICS INC | COM STK | – | 12529R·10·7 | 350,300 | 0.01% | 62,000 | Sh. | 5,650.00 | Defined | #2 | Sole | – | – |
| CARDINAL HEALTH INC | COM | – | 14149Y·10·8 | 352,800 | 0.01% | 3,500 | Sh. | 100,800.00 | Defined | #2 | Sole | – | – |
| CAREDX INC | COM | – | 14167L·10·3 | 47,457,504 | 0.73% | 3,954,792 | Sh. | 12,000.00 | Defined | #3 | Sole | – | – |
| CASTLE BIOSCIENCES INC | COM | – | 14843C·10·5 | 26,594,717 | 0.41% | 1,232,378 | Sh. | 21,580.00 | Defined | #3 | Sole | – | – |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | – | 15117B·20·2 | 95,830,299 | 1.47% | 2,416,296 | Sh. | 39,660.00 | Defined | #1, 2 | Sole | – | – |
| CENCORA INC | COM | – | 03073E·10·5 | 25,903,758 | 0.40% | 126,126 | Sh. | 205,380.00 | Defined | #2 | Sole | – | – |
| CENTENE CORP DEL | COM | – | 15135B·10·1 | 13,314,684 | 0.20% | 179,419 | Sh. | 74,210.00 | Defined | #2 | Sole | – | – |
| CENTENE CORP DEL | COM | – | 15135B·10·1 | 19,475,227 | 0.30% | 262,434 | Sh. | 74,210.00 | Defined | #3 | Sole | – | – |
| CERTARA INC | COM | – | 15687V·10·9 | 1,604,472 | 0.02% | 91,215 | Sh. | 17,590.00 | Defined | #2 | Sole | – | – |
| CHARLES RIV LABS INTL INC | COM | – | 159864·10·7 | 51,477,518 | 0.79% | 217,756 | Sh. | 236,400.00 | Defined | #3 | Sole | – | – |
| COOPER COS INC | COM NEW | – | 216648·40·2 | 32,559,842 | 0.50% | 86,037 | Sh. | 378,440.00 | Defined | #2 | Sole | – | – |
| CRISPR THERAPEUTICS AG | NAMEN AKT | – | H17182·10·8 | 1,277,040 | 0.02% | 20,400 | Sh. | 62,600.00 | Defined | #2 | Sole | – | – |
| CRISPR THERAPEUTICS AG | NAMEN AKT | – | H17182·10·8 | 55,088,000 | 0.84% | 880,000 | Sh. | 62,600.00 | Defined | #1, 2 | Sole | – | – |
| CVS HEALTH CORP | COM | – | 126650·10·0 | 2,487,477 | 0.04% | 31,503 | Sh. | 78,960.00 | Defined | #2 | Sole | – | – |
| CYTOKINETICS INC | COM NEW | – | 23282W·60·5 | 1,577,961 | 0.02% | 18,900 | Sh. | 83,490.00 | Defined | #2 | Sole | – | – |
| DANAHER CORPORATION | COM | – | 235851·10·2 | 19,504,275 | 0.30% | 84,310 | Sh. | 231,340.00 | Defined | #2 | Sole | – | – |
| DAVITA INC | COM | – | 23918K·10·8 | 398,088 | 0.01% | 3,800 | Sh. | 104,760.00 | Defined | #2 | Sole | – | – |
| DEXCOM INC | COM | – | 252131·10·7 | 101,577,592 | 1.55% | 818,580 | Sh. | 124,090.00 | Defined | #2 | Sole | – | – |
| DEXCOM INC | COM | – | 252131·10·7 | 11,914,253 | 0.18% | 96,013 | Sh. | 124,090.00 | Defined | #3 | Sole | – | – |
| DOXIMITY INC | CL A | – | 26622P·10·7 | 7,403,541 | 0.11% | 264,035 | Sh. | 28,040.00 | Defined | #2 | Sole | – | – |
| DR REDDYS LABS LTD | ADR | – | 256135·20·3 | 4,237,422 | 0.06% | 60,900 | Sh. | 69,580.00 | Defined | #2 | Sole | – | – |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | – | 268158·20·1 | 603,936 | 0.01% | 43,200 | Sh. | 13,980.00 | Defined | #2 | Sole | – | – |
| EDWARDS LIFESCIENCES CORP | COM | – | 28176E·10·8 | 77,698,598 | 1.19% | 1,018,998 | Sh. | 76,250.00 | Defined | #2 | Sole | – | – |
| ELEVANCE HEALTH INC | COM | – | 036752·10·3 | 27,505,623 | 0.42% | 58,329 | Sh. | 471,560.00 | Defined | #2 | Sole | – | – |
| ELEVANCE HEALTH INC | COM | – | 036752·10·3 | 23,322,886 | 0.36% | 49,459 | Sh. | 471,560.00 | Defined | #3 | Sole | – | – |
| ELI LILLY & CO | COM | – | 532457·10·8 | 32,767,099 | 0.50% | 56,212 | Sh. | 582,920.00 | Defined | #2 | Sole | – | – |
| ENCOMPASS HEALTH CORP | COM | – | 29261A·10·0 | 793,968 | 0.01% | 11,900 | Sh. | 66,720.00 | Defined | #2 | Sole | – | – |
| ESPERION THERAPEUTICS INC NE | COM | – | 29664W·10·5 | 30,498 | 0.00% | 10,200 | Sh. | 2,990.00 | Defined | #2 | Sole | – | – |
| ESPERION THERAPEUTICS INC NE | COM | – | 29664W·10·5 | 12,540,251 | 0.19% | 4,194,064 | Sh. | 2,990.00 | Defined | #1, 2 | Sole | – | – |
| ESSA PHARMA INC | COM NEW | – | 29668H·70·8 | 125,400 | 0.00% | 19,000 | Sh. | 6,600.00 | Defined | #2 | Sole | – | – |
| ESSA PHARMA INC | COM NEW | – | 29668H·70·8 | 52,005,248 | 0.80% | 7,879,583 | Sh. | 6,600.00 | Defined | #1, 2 | Sole | – | – |
| EVOLENT HEALTH INC | CL A | – | 30050B·10·1 | 10,210,696 | 0.16% | 309,134 | Sh. | 33,030.00 | Defined | #2 | Sole | – | – |
| EVOLENT HEALTH INC | CL A | – | 30050B·10·1 | 68,301,350 | 1.04% | 2,067,858 | Sh. | 33,030.00 | Defined | #3 | Sole | – | – |
| EXACT SCIENCES CORP | COM | – | 30063P·10·5 | 15,933,590 | 0.24% | 215,377 | Sh. | 73,980.00 | Defined | #2 | Sole | – | – |
| EXACT SCIENCES CORP | COM | – | 30063P·10·5 | 61,581,618 | 0.94% | 832,409 | Sh. | 73,980.00 | Defined | #3 | Sole | – | – |
| EXELIXIS INC | COM | – | 30161Q·10·4 | 2,593,319 | 0.04% | 108,100 | Sh. | 23,990.00 | Defined | #2 | Sole | – | – |
| EXELIXIS INC | COM | – | 30161Q·10·4 | 47,980,000 | 0.73% | 2,000,000 | Sh. | 23,990.00 | Defined | #1, 2 | Sole | – | – |
| EXSCIENTIA PLC | COM | – | 30223G·10·2 | 11,314 | 0.00% | 1,765 | Sh. | 6,410.20 | Defined | #2 | Sole | – | – |
| FATE THERAPEUTICS INC | COM | – | 31189P·10·2 | 44,132 | 0.00% | 11,800 | Sh. | 3,740.00 | Defined | #2 | Sole | – | – |
| FATE THERAPEUTICS INC | COM | – | 31189P·10·2 | 18,100,773 | 0.28% | 4,839,779 | Sh. | 3,740.00 | Defined | #1, 2 | Sole | – | – |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | – | 36266G·10·7 | 41,380,427 | 0.63% | 535,184 | Sh. | 77,320.00 | Defined | #2 | Sole | – | – |
| GENERATION BIO CO | COM | – | 37148K·10·0 | 14,520 | 0.00% | 8,800 | Sh. | 1,650.00 | Defined | #2 | Sole | – | – |
| GENERATION BIO CO | COM | – | 37148K·10·0 | 5,953,662 | 0.09% | 3,608,280 | Sh. | 1,650.00 | Defined | #1, 2 | Sole | – | – |
| GILEAD SCIENCES INC | COM | – | 375558·10·3 | 4,156,218 | 0.06% | 51,305 | Sh. | 81,010.00 | Defined | #2 | Sole | – | – |
| GLOBUS MED INC | CL A | – | 379577·20·8 | 32,388,170 | 0.50% | 607,772 | Sh. | 53,290.00 | Defined | #2 | Sole | – | – |
| HCA HEALTHCARE INC | COM | – | 40412C·10·1 | 41,191,541 | 0.63% | 152,178 | Sh. | 270,680.00 | Defined | #2 | Sole | – | – |
| HOLOGIC INC | COM | – | 436440·10·1 | 20,710,783 | 0.32% | 289,864 | Sh. | 71,450.00 | Defined | #2 | Sole | – | – |
| HUMANA INC | COM | – | 444859·10·2 | 45,997,086 | 0.70% | 100,472 | Sh. | 457,810.00 | Defined | #2 | Sole | – | – |
| HUTCHMED CHINA LTD | SPONSORED ADS | – | 44842L·10·3 | 1,045,506 | 0.02% | 58,000 | Sh. | 18,025.97 | Defined | #2 | Sole | – | – |
| HUTCHMED CHINA LTD | SPONSORED ADS | – | 44842L·10·3 | 19,343,856 | 0.30% | 1,073,111 | Sh. | 18,025.96 | Defined | #3 | Sole | – | – |
| IDEXX LABS INC | COM | – | 45168D·10·4 | 52,235,756 | 0.80% | 94,110 | Sh. | 555,050.01 | Defined | #2 | Sole | – | – |
| ILLUMINA INC | COM | – | 452327·10·9 | 6,264,825 | 0.10% | 44,993 | Sh. | 139,239.99 | Defined | #2 | Sole | – | – |
| IMMUNOCORE HLDGS PLC | ADS | – | 45258D·10·5 | 710,528 | 0.01% | 10,400 | Sh. | 68,320.00 | Defined | #2 | Sole | – | – |
| IMMUNOCORE HLDGS PLC | ADS | – | 45258D·10·5 | 65,973,481 | 1.01% | 965,654 | Sh. | 68,320.00 | Defined | #1, 2 | Sole | – | – |
| INCYTE CORP | COM | – | 45337C·10·2 | 421,886 | 0.01% | 6,719 | Sh. | 62,790.00 | Defined | #2 | Sole | – | – |
| INCYTE CORP | COM | – | 45337C·10·2 | 134,998,500 | 2.06% | 2,150,000 | Sh. | 62,790.00 | Defined | #1, 2 | Sole | – | – |
| INHIBRX INC | COM | – | 45720L·10·7 | 934,800 | 0.01% | 24,600 | Sh. | 38,000.00 | Defined | #2 | Sole | – | – |
| INSMED INC | COM PAR $.01 | – | 457669·30·7 | 1,196,214 | 0.02% | 38,600 | Sh. | 30,990.00 | Defined | #2 | Sole | – | – |
| INSMED INC | COM PAR $.01 | – | 457669·30·7 | 69,800,574 | 1.07% | 2,252,358 | Sh. | 30,990.00 | Defined | #3 | Sole | – | – |
| INSPIRE MED SYS INC | COM | – | 457730·10·9 | 18,445,405 | 0.28% | 90,672 | Sh. | 203,430.00 | Defined | #2 | Sole | – | – |
| INSPIRE MED SYS INC | COM | – | 457730·10·9 | 25,414,103 | 0.39% | 124,928 | Sh. | 203,430.00 | Defined | #3 | Sole | – | – |
| INSULET CORP | COM | – | 45784P·10·1 | 62,902,502 | 0.96% | 289,900 | Sh. | 216,980.00 | Defined | #2 | Sole | – | – |
| INTRA-CELLULAR THERAPIES INC | COM | – | 46116X·10·1 | 1,890,768 | 0.03% | 26,400 | Sh. | 71,620.00 | Defined | #2 | Sole | – | – |
| INTRA-CELLULAR THERAPIES INC | COM | – | 46116X·10·1 | 217,724,800 | 3.33% | 3,040,000 | Sh. | 71,620.00 | Defined | #1, 2 | Sole | – | – |
| INTUITIVE SURGICAL INC | COM NEW | – | 46120E·60·2 | 234,521,876 | 3.59% | 695,168 | Sh. | 337,360.00 | Defined | #2 | Sole | – | – |
| INTUITIVE SURGICAL INC | COM NEW | – | 46120E·60·2 | 46,175,475 | 0.71% | 136,873 | Sh. | 337,360.00 | Defined | #3 | Sole | – | – |
| IONIS PHARMACEUTICALS INC | COM | – | 462222·10·0 | 6,272,502 | 0.10% | 123,987 | Sh. | 50,590.00 | Defined | #2 | Sole | – | – |
| IONIS PHARMACEUTICALS INC | COM | – | 462222·10·0 | 434,568,100 | 6.65% | 8,590,000 | Sh. | 50,590.00 | Defined | #1, 2 | Sole | – | – |
| IONQ INC | COM | – | 46222L·10·8 | 9,181 | 0.00% | 741 | Sh. | 12,390.01 | Defined | #2 | Sole | – | – |
| IQVIA HLGS INC | COM | – | 46266C·10·5 | 1,911,199 | 0.03% | 8,260 | Sh. | 231,380.02 | Defined | #2 | Sole | – | – |
| ISHARES TR | MSCI CHINA ETF | – | 46429B·67·1 | 167,034 | 0.00% | 4,100 | Sh. | 40,740.00 | Defined | #2 | Sole | – | – |
| JOHNSON & JOHNSON | COM | – | 478160·10·4 | 4,432,607 | 0.07% | 28,280 | Sh. | 156,739.99 | Defined | #2 | Sole | – | – |
| KARUNA THERAPEUTICS INC | COM | – | 48576A·10·0 | 1,930,711 | 0.03% | 6,100 | Sh. | 316,510.00 | Defined | #2 | Sole | – | – |
| KOSMOS ENERGY LTD | COM | – | 500688·10·6 | 1,721,115 | 0.03% | 256,500 | Sh. | 6,710.00 | Defined | #2 | Sole | – | – |
| KRYSTAL BIOTECH INC | COM | – | 501147·10·2 | 992,480 | 0.02% | 8,000 | Sh. | 124,060.00 | Defined | #2 | Sole | – | – |
| LABORATORY CORP AMER HLDGS | COM NEW | – | 50540R·40·9 | 1,611,259 | 0.02% | 7,089 | Sh. | 227,290.03 | Defined | #2 | Sole | – | – |
| LEGEND BIOTECH CORP | SPONSORED ADS | – | 52490G·10·2 | 12,139,538 | 0.19% | 201,754 | Sh. | 60,170.00 | Defined | #2 | Sole | – | – |
| LIFE TIME GROUP HOLDINGS INC | COMMON STOCK | – | 53190C·10·2 | 380,016 | 0.01% | 25,200 | Sh. | 15,080.00 | Defined | #2 | Sole | – | – |
| LULULEMON ATHLETICA INC | COM | – | 550021·10·9 | 393,693 | 0.01% | 770 | Sh. | 511,289.61 | Defined | #2 | Sole | – | – |
| MACROGENICS INC | COM | – | 556099·10·9 | 224,627 | 0.00% | 23,350 | Sh. | 9,620.00 | Defined | #2 | Sole | – | – |
| MACROGENICS INC | COM | – | 556099·10·9 | 95,526,244 | 1.46% | 9,929,963 | Sh. | 9,620.00 | Defined | #1, 2 | Sole | – | – |
| MCKESSON CORP | COM | – | 58155Q·10·3 | 2,246,842 | 0.03% | 4,853 | Sh. | 462,980.01 | Defined | #2 | Sole | – | – |
| MEDTRONIC PLC | SHS | – | G5960L·10·3 | 79,972,197 | 1.22% | 970,772 | Sh. | 82,380.00 | Defined | #2 | Sole | – | – |
| MERCK & CO INC | COM | – | 58933Y·10·5 | 31,638,258 | 0.48% | 290,206 | Sh. | 109,020.00 | Defined | #2 | Sole | – | – |
| MERUS N V | COM | – | N5749R·10·0 | 624,250 | 0.01% | 22,700 | Sh. | 27,500.00 | Defined | #2 | Sole | – | – |
| METTLER TOLEDO INTERNATIONAL | COM | – | 592688·10·5 | 30,324 | 0.00% | 25 | Sh. | 1,212,960.00 | Defined | #2 | Sole | – | – |
| MICROSOFT CORP | COM | – | 594918·10·4 | 45,877 | 0.00% | 122 | Sh. | 376,040.98 | Defined | #2 | Sole | – | – |
| MODERNA INC | COM | – | 60770K·10·7 | 1,724,960 | 0.03% | 17,345 | Sh. | 99,449.99 | Defined | #2 | Sole | – | – |
| MODERNA INC | COM | – | 60770K·10·7 | 188,067,409 | 2.88% | 1,891,075 | Sh. | 99,450.00 | Defined | #1, 2 | Sole | – | – |
| MOLECULAR TEMPLATES INC | COM NEW | – | 608550·20·8 | 3,841,229 | 0.06% | 1,029,820 | Sh. | 3,730.00 | Defined | #1, 2 | Sole | – | – |
| MOLINA HEALTHCARE INC | COM | – | 60855R·10·0 | 33,051,194 | 0.51% | 91,476 | Sh. | 361,310.00 | Defined | #2 | Sole | – | – |
| NATERA INC | COM | – | 632307·10·4 | 16,072,422 | 0.25% | 256,584 | Sh. | 62,640.00 | Defined | #2 | Sole | – | – |
| NEUROCRINE BIOSCIENCES INC | COM | – | 64125C·10·9 | 2,701,080 | 0.04% | 20,500 | Sh. | 131,760.00 | Defined | #2 | Sole | – | – |
| NEUROCRINE BIOSCIENCES INC | COM | – | 64125C·10·9 | 317,541,600 | 4.86% | 2,410,000 | Sh. | 131,760.00 | Defined | #1, 2 | Sole | – | – |
| NEVRO CORP | COM | – | 64157F·10·3 | 4,246,412 | 0.06% | 197,324 | Sh. | 21,520.00 | Defined | #2 | Sole | – | – |
| NIKE INC | CL B | – | 654106·10·3 | 369,138 | 0.01% | 3,400 | Sh. | 108,570.00 | Defined | #2 | Sole | – | – |
| NVIDIA CORPORATION | COM | – | 67066G·10·4 | 49,027 | 0.00% | 99 | Sh. | 495,222.22 | Defined | #2 | Sole | – | – |
| OMNICELL INC | COM | – | 68213N·10·9 | 8,422,196 | 0.13% | 223,816 | Sh. | 37,630.00 | Defined | #2 | Sole | – | – |
| OPTION CARE HEALTH INC | COM NEW | – | 68404L·20·1 | 65,318,408 | 1.00% | 1,938,807 | Sh. | 33,690.00 | Defined | #3 | Sole | – | – |
| ORACLE CORP | COM | – | 68389X·10·5 | 47,865 | 0.00% | 454 | Sh. | 105,429.52 | Defined | #2 | Sole | – | – |
| OUTSET MEDICAL INC | COM | – | 690145·10·7 | 2,944,425 | 0.05% | 544,256 | Sh. | 5,410.00 | Defined | #2 | Sole | – | – |
| OUTSET MEDICAL INC | COM | – | 690145·10·7 | 6,577,900 | 0.10% | 1,215,878 | Sh. | 5,410.00 | Defined | #3 | Sole | – | – |
| PACIFIC BIOSCIENCES CALIF IN | COM | – | 69404D·10·8 | 18,150,540 | 0.28% | 1,850,208 | Sh. | 9,810.00 | Defined | #2 | Sole | – | – |
| PACIFIC BIOSCIENCES CALIF IN | COM | – | 69404D·10·8 | 53,630,485 | 0.82% | 5,466,920 | Sh. | 9,810.00 | Defined | #3 | Sole | – | – |
| PENUMBRA INC | COM | – | 70975L·10·7 | 51,074,191 | 0.78% | 203,046 | Sh. | 251,540.00 | Defined | #2 | Sole | – | – |
| PFIZER INC | COM | – | 717081·10·3 | 658,370 | 0.01% | 22,868 | Sh. | 28,790.01 | Defined | #2 | Sole | – | – |
| PHREESIA INC | COM | – | 71944F·10·6 | 9,759,415 | 0.15% | 421,573 | Sh. | 23,150.00 | Defined | #2 | Sole | – | – |
| PRIVIA HEALTH GROUP INC | COM | – | 74276R·10·2 | 24,220,559 | 0.37% | 1,051,696 | Sh. | 23,030.00 | Defined | #2 | Sole | – | – |
| PROCEPT BIOROBOTICS CORP | COM | – | 74276L·10·5 | 37,104,851 | 0.57% | 885,346 | Sh. | 41,910.00 | Defined | #2 | Sole | – | – |
| PROTAGONIST THERAPEUTICS INC | COM | – | 74366E·10·2 | 687,900 | 0.01% | 30,000 | Sh. | 22,930.00 | Defined | #2 | Sole | – | – |
| QUALCOMM INC | COM | – | 747525·10·3 | 50,187 | 0.00% | 347 | Sh. | 144,631.12 | Defined | #2 | Sole | – | – |
| RECURSION PHARMACEUTICALS IN | CL A | – | 75629V·10·4 | 1,721,132 | 0.03% | 174,557 | Sh. | 9,860.00 | Defined | #2 | Sole | – | – |
| REGENERON PHARMACEUTICALS | COM | – | 75886F·10·7 | 9,405,608 | 0.14% | 10,709 | Sh. | 878,290.04 | Defined | #2 | Sole | – | – |
| RELAY THERAPEUTICS INC | COM | – | 75943R·10·2 | 122,013 | 0.00% | 11,082 | Sh. | 11,010.02 | Defined | #2 | Sole | – | – |
| RELAY THERAPEUTICS INC | COM | – | 75943R·10·2 | 65,234,250 | 1.00% | 5,925,000 | Sh. | 11,010.00 | Defined | #1, 2 | Sole | – | – |
| RESMED INC | COM | – | 761152·10·7 | 5,215,646 | 0.08% | 30,320 | Sh. | 172,019.99 | Defined | #2 | Sole | – | – |
| REVOLUTION MEDICINES INC | COM | – | 76155X·10·0 | 1,270,524 | 0.02% | 44,300 | Sh. | 28,680.00 | Defined | #2 | Sole | – | – |
| REVOLUTION MEDICINES INC | COM | – | 76155X·10·0 | 144,739,356 | 2.21% | 5,046,700 | Sh. | 28,680.00 | Defined | #1, 2 | Sole | – | – |
| RHYTHM PHARMACEUTICALS INC | COM | – | 76243J·10·5 | 1,510,988 | 0.02% | 32,869 | Sh. | 45,970.00 | Defined | #2 | Sole | – | – |
| ROCKET PHARMACEUTICALS INC | COM | – | 77313F·10·6 | 629,370 | 0.01% | 21,000 | Sh. | 29,970.00 | Defined | #2 | Sole | – | – |
| SAGE THERAPEUTICS INC | COM | – | 78667J·10·8 | 180,966 | 0.00% | 8,351 | Sh. | 21,669.98 | Defined | #2 | Sole | – | – |
| SAGE THERAPEUTICS INC | COM | – | 78667J·10·8 | 75,953,350 | 1.16% | 3,505,000 | Sh. | 21,670.00 | Defined | #1, 2 | Sole | – | – |
| SAREPTA THERAPEUTICS INC | COM | – | 803607·10·0 | 540,008 | 0.01% | 5,600 | Sh. | 96,430.00 | Defined | #2 | Sole | – | – |
| SAREPTA THERAPEUTICS INC | COM | – | 803607·10·0 | 22,341,481 | 0.34% | 231,686 | Sh. | 96,430.00 | Defined | #3 | Sole | – | – |
| SCHOLAR ROCK HLDG CORP | COM | – | 80706P·10·3 | 680,560 | 0.01% | 36,200 | Sh. | 18,800.00 | Defined | #2 | Sole | – | – |
| SCHOLAR ROCK HLDG CORP | COM | – | 80706P·10·3 | 40,095,230 | 0.61% | 2,132,725 | Sh. | 18,800.00 | Defined | #1, 2 | Sole | – | – |
| SHOCKWAVE MED INC | COM | – | 82489T·10·4 | 23,783,794 | 0.36% | 124,810 | Sh. | 190,560.00 | Defined | #2 | Sole | – | – |
| SI-BONE INC | COM | – | 825704·10·9 | 2,627,948 | 0.04% | 125,200 | Sh. | 20,990.00 | Defined | #3 | Sole | – | – |
| SILK RD MED INC | COM | – | 82710M·10·0 | 17,615,818 | 0.27% | 1,435,682 | Sh. | 12,270.00 | Defined | #3 | Sole | – | – |
| SPDR S&P 500 ETF TR | TR UNIT | – | 78462F·10·3 | 1,235,806 | 0.02% | 2,600 | Sh. | 475,310.00 | Defined | #2 | Sole | – | – |
| SPDR SER TR | S&P OILGAS EXP | – | 78468R·55·6 | 533,949 | 0.01% | 3,900 | Sh. | 136,910.00 | Defined | #2 | Sole | – | – |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | – | 86366E·10·6 | 501,348 | 0.01% | 12,300 | Sh. | 40,760.00 | Defined | #2 | Sole | – | – |
| STRYKER CORPORATION | COM | – | 863667·10·1 | 139,465,709 | 2.13% | 465,724 | Sh. | 299,460.00 | Defined | #2 | Sole | – | – |
| SUPERNUS PHARMACEUTICALS INC | COM | – | 868459·10·8 | 436,994 | 0.01% | 15,100 | Sh. | 28,940.00 | Defined | #2 | Sole | – | – |
| TANDEM DIABETES CARE INC | COM NEW | – | 875372·20·3 | 58,932,737 | 0.90% | 1,992,317 | Sh. | 29,580.00 | Defined | #3 | Sole | – | – |
| TELADOC HEALTH INC | COM | – | 87918A·10·5 | 5,590,156 | 0.09% | 259,404 | Sh. | 21,550.00 | Defined | #2 | Sole | – | – |
| TENET HEALTHCARE CORP | COM NEW | – | 88033G·40·7 | 109,350 | 0.00% | 1,447 | Sh. | 75,570.15 | Defined | #2 | Sole | – | – |
| THE CIGNA GROUP | COM | – | 125523·10·0 | 26,492,342 | 0.41% | 88,470 | Sh. | 299,450.01 | Defined | #2 | Sole | – | – |
| THERMO FISHER SCIENTIFIC INC | COM | – | 883556·10·2 | 18,759,180 | 0.29% | 35,342 | Sh. | 530,789.99 | Defined | #2 | Sole | – | – |
| TRANSMEDICS GROUP INC | COM | – | 89377M·10·9 | 40,955,988 | 0.63% | 518,890 | Sh. | 78,930.00 | Defined | #2 | Sole | – | – |
| UNITEDHEALTH GROUP INC | COM | – | 91324P·10·2 | 46,428,336 | 0.71% | 88,188 | Sh. | 526,470.00 | Defined | #2 | Sole | – | – |
| UNITEDHEALTH GROUP INC | COM | – | 91324P·10·2 | 26,304,547 | 0.40% | 49,964 | Sh. | 526,470.00 | Defined | #3 | Sole | – | – |
| VANECK ETF TRUST | GOLD MINERS ETF | – | 92189F·10·6 | 1,023,330 | 0.02% | 33,000 | Sh. | 31,010.00 | Defined | #2 | Sole | – | – |
| VANECK ETF TRUST | JUNIOR GOLD MINE | – | 92189F·79·1 | 189,550 | 0.00% | 5,000 | Sh. | 37,910.00 | Defined | #2 | Sole | – | – |
| VAXCYTE INC | COM | – | 92243G·10·8 | 992,240 | 0.02% | 15,800 | Sh. | 62,800.00 | Defined | #2 | Sole | – | – |
| VEEVA SYS INC | CL A COM | – | 922475·10·8 | 37,543,903 | 0.57% | 195,013 | Sh. | 192,520.00 | Defined | #2 | Sole | – | – |
| VERONA PHARMA PLC | SPONSORED ADS | – | 925050·10·6 | 755,440 | 0.01% | 38,000 | Sh. | 19,880.00 | Defined | #2 | Sole | – | – |
| VERONA PHARMA PLC | SPONSORED ADS | – | 925050·10·6 | 15,943,680 | 0.24% | 801,996 | Sh. | 19,880.00 | Defined | #3 | Sole | – | – |
| VERTEX PHARMACEUTICALS INC | COM | – | 92532F·10·0 | 39,220,127 | 0.60% | 96,390 | Sh. | 406,890.00 | Defined | #2 | Sole | – | – |
| VERTEX PHARMACEUTICALS INC | COM | – | 92532F·10·0 | 260,409,600 | 3.98% | 640,000 | Sh. | 406,890.00 | Defined | #1, 2 | Sole | – | – |
| VERVE THERAPEUTICS INC | COM | – | 92539P·10·1 | 543,660 | 0.01% | 39,000 | Sh. | 13,940.00 | Defined | #2 | Sole | – | – |
| VIATRIS INC | COM | – | 92556V·10·6 | 194,972 | 0.00% | 18,003 | Sh. | 10,829.97 | Defined | #2 | Sole | – | – |
| VIKING THERAPEUTICS INC | COM | – | 92686J·10·6 | 325,675 | 0.00% | 17,500 | Sh. | 18,610.00 | Defined | #2 | Sole | – | – |
| VIRIDIAN THERAPEUTICS INC | COM | – | 92790C·10·4 | 653,400 | 0.01% | 30,000 | Sh. | 21,780.00 | Defined | #2 | Sole | – | – |
| WAVE LIFE SCIENCES LTD | SHS | – | Y95308·10·5 | 22,697,013 | 0.35% | 4,494,458 | Sh. | 5,050.00 | Defined | #1, 2 | Sole | – | – |
| WW INTL INC | COM | – | 98262P·10·1 | 350,000 | 0.01% | 40,000 | Sh. | 8,750.00 | Defined | #2 | Sole | – | – |
| XENON PHARMACEUTICALS INC | COM | – | 98420N·10·5 | 1,013,320 | 0.02% | 22,000 | Sh. | 46,060.00 | Defined | #2 | Sole | – | – |
| ZAI LAB LTD | ADR | – | 98887Q·10·4 | 3,714,332 | 0.06% | 135,000 | Sh. | 27,513.57 | Defined | #2 | Sole | – | – |
| ZIMMER BIOMET HOLDINGS INC | COM | – | 98956P·10·2 | 34,208,410 | 0.52% | 281,088 | Sh. | 121,700.00 | Defined | #2 | Sole | – | – |
| ZOETIS INC | CL A | – | 98978V·10·3 | 1,142,772 | 0.02% | 5,790 | Sh. | 197,369.95 | Defined | #2 | Sole | – | – |
| — 160 Issuers — | — 161 Issues — | — 202 Holdings: $6,537,470,217,000 — | — 4 Managersº — |
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ª No market value of any Holding was adjusted.
º Other Included Managers with whom investment discretion is shared as to any Holding: 3 Other Included Managers... |
See: Recent Holdings Reports for this and Related Money Managers
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