<SUBMISSION>
<SECRELEASE-DATETIME> 20080523-134225 ⇐ Metadata from SEC Info (ET)
<SECWEBSITE-DATETIME> 20080523-134225 ⇐ Metadata from SEC Info (ET)
<ACCEPTANCE-DATETIME> 20080523-132633 ⇐ Filing accepted by SEC (ET)
<ACCESSION-NUMBER> 0000950103-08-001391
<TYPE> 8-K
<PUBLIC-DOCUMENT-COUNT> 22
<PERIOD> 20080523
<ITEMS> 1.01
<ITEMS> 2.03
<ITEMS> 8.01
<ITEMS> 9.01
<FILING-DATE> 20080523
<DATE-OF-FILING-DATE-CHANGE> 20080523
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<FILER>
<COMPANY-DATA>
<CONFORMED-NAME> Shire Ltd.
<CIK> 0000936402
<ASSIGNED-SIC> 2834
<IRS-NUMBER> 000000000
<FISCAL-YEAR-END> 1231
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE> 8-K
<ACT> 34
<FILE-NUMBER> 000-29630
<FILM-NUMBER> 08857435
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1> HAMPSHIRE INTL BUSINESS PARK
<STREET2> CHINEHAM BASINGSTOKE
<CITY> HAMPSHIRE ENGLAND RG
<STATE> X0 ⇐ This is an SEC Country/Territory Code for
United Kingdom {GB|GBR}
<ZIP> -
<PHONE> 1264333455
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1> HAMPSHIRE INTL BUSINESS PARK
<STREET2> CHINEHAM BASINGSTOKE
<CITY> HAMPSHIRE ENGLAND RG
<STATE> X0 ⇐ This is an SEC Country/Territory Code for
United Kingdom {GB|GBR}
<ZIP> -
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME> Shire plc
<DATE-CHANGED> 20051125
</FORMER-COMPANY>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME> SHIRE PHARMACEUTICALS GROUP PLC
<DATE-CHANGED> 19980302
</FORMER-COMPANY>
</FILER>
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<DOCUMENT>
<TYPE> 8-K
<SEQUENCE> 1
<FILENAME> dp09775_8k.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-3.1
<SEQUENCE> 2
<FILENAME> dp09775_ex0301.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-4.1
<SEQUENCE> 3
<FILENAME> dp09775_ex0401.htm
<TEXT>
<html>
Show <HTML>: 453 lines (widest: 421 characters) - 44K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-4.2
<SEQUENCE> 4
<FILENAME> dp09775d_ex0402.htm
<TEXT>
<HTML>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-4.3
<SEQUENCE> 5
<FILENAME> dp09775_ex0403.htm
<TEXT>
<html>
Show <HTML>: 335 lines (widest: 1,023 characters) - 28K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> GRAPHIC
<SEQUENCE> 6 ⇐ Not a Document/Exhibit
<FILENAME> shire_logo.jpg
<DESCRIPTION> GRAPHIC
<TEXT>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> GRAPHIC
<SEQUENCE> 7 ⇐ Not a Document/Exhibit
<FILENAME> sig1.jpg
<DESCRIPTION> GRAPHIC
<TEXT>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> GRAPHIC
<SEQUENCE> 8 ⇐ Not a Document/Exhibit
<FILENAME> sig2.jpg
<DESCRIPTION> GRAPHIC
<TEXT>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-4.4
<SEQUENCE> 9 ⇐ Document/Exhibit 6
<FILENAME> dp09775_ex0404.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.1
<SEQUENCE> 10 ⇐ Document/Exhibit 7
<FILENAME> dp09755_ex1001.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> GRAPHIC
<SEQUENCE> 11 ⇐ Not a Document/Exhibit
<FILENAME> p121a.jpg
<DESCRIPTION> GRAPHIC
<TEXT>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> GRAPHIC
<SEQUENCE> 12 ⇐ Not a Document/Exhibit
<FILENAME> p121b.jpg
<DESCRIPTION> GRAPHIC
<TEXT>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.2
<SEQUENCE> 13 ⇐ Document/Exhibit 8
<FILENAME> dp09775_ex1002.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.3
<SEQUENCE> 14 ⇐ Document/Exhibit 9
<FILENAME> dp09775_ex1003.htm
<TEXT>
<html>
Show <HTML>: 1,235 lines (widest: 636 characters) - 89K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.4
<SEQUENCE> 15 ⇐ Document/Exhibit 10
<FILENAME> dp09775_ex1004.htm
<TEXT>
<html>
Show <HTML>: 439 lines (widest: 275 characters) - 31K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.5
<SEQUENCE> 16 ⇐ Document/Exhibit 11
<FILENAME> dp09775_ex1005.htm
<TEXT>
<html>
Show <HTML>: 252 lines (widest: 338 characters) - 20K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.6
<SEQUENCE> 17 ⇐ Document/Exhibit 12
<FILENAME> dp09775_ex1006.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-10.7
<SEQUENCE> 18 ⇐ Document/Exhibit 13
<FILENAME> dp09775_ex1007.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-99.1
<SEQUENCE> 19 ⇐ Document/Exhibit 14
<FILENAME> dp09775_ex9901.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-99.2
<SEQUENCE> 20 ⇐ Document/Exhibit 15
<FILENAME> dp09775_ex9902.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-99.3
<SEQUENCE> 21 ⇐ Document/Exhibit 16
<FILENAME> dp09775_ex9903.htm
<TEXT>
<html>
Show <HTML>: 257 lines (widest: 282 characters) - 20K bytes
</TEXT>
</DOCUMENT>
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<DOCUMENT>
<TYPE> EX-99.4
<SEQUENCE> 22 ⇐ Document/Exhibit 17
<FILENAME> dp09775_ex9904.htm
<TEXT>
<html>
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</TEXT>
</DOCUMENT>
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</SUBMISSION> |
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