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FMR LLC – ‘4’ for 2/17/16 re: Proteostasis Therapeutics, Inc.

On:  Thursday, 2/18/16, at 2:00pm ET   ·   For:  2/17/16   ·   Accession #:  315066-16-5625   ·   File #:  1-37695

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer

 2/18/16  FMR LLC                           4                      2:14K  Proteostasis Therapeutics, Inc.

Statement of Changes in Beneficial Ownership of Securities by an Insider   —   Form 4   —   SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 4           Statement of Changes in Beneficial Ownership of     HTML      3K 
                Securities by an Insider -- primary_doc.xml/3.6                  
 2: EX-24       EX-24 Document                                         1      6K

‘4’   —   Statement of Changes in Beneficial Ownership of Securities by an Insider — primary_doc.xml/3.6



        

This ‘4’ Document is an XML Data File that may be rendered in various formats:

  Form 4    –   Plain Text   –  SEC Website  –  EDGAR System  –    XML Data    –  <?xml?> File
 
 
Plain Text rendering:  Statement of Changes in Beneficial Ownership of Securities by an Insider
 
                                                                                                                                                                                
Ownership Document
 
Schema Version:  X0306
Document Type:  4
Period of Report:  2/17/16
Not Subject to Section 16:  1
Issuer:
Issuer CIK:  1445283
Issuer Name:  PROTEOSTASIS THERAPEUTICS, INC.
Issuer Trading Symbol:  PTI
Reporting Owner:
Reporting Owner ID:
Owner CIK:  315066
Owner Name:  FMR LLC
Reporting Owner Address:
Owner Street 1:  245 SUMMER STREET
Owner Street 2:
Owner City:  BOSTON
Owner State:  MA
Owner ZIP Code:  02210
Owner State Description:
Reporting Owner Relationship:
Is Director?  No
Is Officer?  No
Is Ten Percent Owner?  No
Is Other?  Yes
Other Text:  See Remark 1
Non-Derivative Table:
Non-Derivative Transaction:
Security Title:
Value:  Common Stock
Transaction Date:
Value:  2/17/16
Transaction Coding:
Transaction Form Type:  4
Transaction Code:  C
Equity Swap Involved?  No
Transaction Timeliness:
Value:
Transaction Amounts:
Transaction Shares:
Value:  925,051
Transaction Price Per Share:
Footnote ID:  F1
Transaction Acquired-Disposed Code:
Value:  A
Post-Transaction Amounts:
Shares Owned Following Transaction:
Value:  1,318,932
Footnote ID:  F2
Ownership Nature:
Direct or Indirect Ownership:
Value:  I
Nature of Ownership:
Value:  F-Prime Capital Partners Healthcare Fund II LP
Non-Derivative Transaction:
Security Title:
Value:  Common Stock
Transaction Date:
Value:  2/17/16
Transaction Coding:
Transaction Form Type:  4
Transaction Code:  C
Equity Swap Involved?  No
Transaction Timeliness:
Value:
Transaction Amounts:
Transaction Shares:
Value:  183,880
Transaction Price Per Share:
Footnote ID:  F1
Transaction Acquired-Disposed Code:
Value:  A
Post-Transaction Amounts:
Shares Owned Following Transaction:
Value:  1,502,812
Ownership Nature:
Direct or Indirect Ownership:
Value:  I
Nature of Ownership:
Value:  F-Prime Capital Partners Healthcare Fund II LP
Non-Derivative Transaction:
Security Title:
Value:  Common Stock
Transaction Date:
Value:  2/17/16
Transaction Coding:
Transaction Form Type:  4
Transaction Code:  P
Equity Swap Involved?  No
Transaction Timeliness:
Value:
Transaction Amounts:
Transaction Shares:
Value:  375,000
Transaction Price Per Share:
Value:  8
Transaction Acquired-Disposed Code:
Value:  A
Post-Transaction Amounts:
Shares Owned Following Transaction:
Value:  1,877,812
Ownership Nature:
Direct or Indirect Ownership:
Value:  I
Nature of Ownership:
Value:  F-Prime Capital Partners Healthcare Fund II LP
Derivative Table:
Derivative Transaction:
Security Title:
Value:  Series A Convertible Preferred Stock
Conversion or Exercise Price:
Footnote ID:  F1
Transaction Date:
Value:  2/17/16
Transaction Coding:
Transaction Form Type:  4
Transaction Code:  C
Equity Swap Involved?  No
Transaction Timeliness:
Value:
Transaction Amounts:
Transaction Shares:
Value:  10,000,000
Transaction Price Per Share:
Footnote ID:  F1
Transaction Acquired-Disposed Code:
Value:  D
Exercise Date:
Footnote ID:  F1
Expiration Date:
Footnote ID:  F1
Underlying Security:
Underlying Security Title:
Value:  Common Stock
Underlying Security Shares:
Value:  925,051
Post-Transaction Amounts:
Shares Owned Following Transaction:
Value:  0
Ownership Nature:
Direct or Indirect Ownership:
Value:  I
Nature of Ownership:
Value:  F-Prime Capital Partners Healthcare Fund II LP
Derivative Transaction:
Security Title:
Value:  Series B Convertible Preferred Stock
Conversion or Exercise Price:
Footnote ID:  F1
Transaction Date:
Value:  2/17/16
Transaction Coding:
Transaction Form Type:  4
Transaction Code:  C
Equity Swap Involved?  No
Transaction Timeliness:
Value:
Transaction Amounts:
Transaction Shares:
Value:  1,987,782
Transaction Price Per Share:
Footnote ID:  F1
Transaction Acquired-Disposed Code:
Value:  D
Exercise Date:
Footnote ID:  F1
Expiration Date:
Footnote ID:  F1
Underlying Security:
Underlying Security Title:
Value:  Common Stock
Underlying Security Shares:
Value:  183,880
Post-Transaction Amounts:
Shares Owned Following Transaction:
Value:  0
Ownership Nature:
Direct or Indirect Ownership:
Value:  I
Nature of Ownership:
Value:  F-Prime Capital Partners Healthcare Fund II LP
Footnotes:
Footnote - F1:  On February 17, 2016, in connection with the completion of the issuer's initial public offering, all shares of Convertible Preferred Stock converted into shares of Common Stock at a 10.8102-for-one conversion ratio.
Footnote - F2:  Includes 393,881 shares of Common Stock issued as payment of accrued dividends upon conversion of the Series A Convertible Preferred Stock on February 17, 2016.
Remarks:  Remark 1: Abigail P. Johnson is a Director, the Vice Chairman, the Chief Executive Officer and the President of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. The address of Abigail P. Johnson is c/o FMR LLC, 245 Summer Street, Boston, MA 02110. Remark 2: The general partner of F-Prime Capital Partners Healthcare Fund II LP is F-Prime Capital Partners Healthcare Advisors Fund II LP. F-Prime Capital Partners Healthcare Advisors Fund II LP is solely managed by Impresa Management LLC, its general partner and investment manager. Impresa Management LLC is owned, directly or indirectly, by various shareholders and employees of FMR LLC, including certain members of the Johnson family. Exhibit List: Exhibit 24 - Powers of Attorney.
Owner Signature:
Signature Name:  Daniel T. Gallagher, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries and Abigail P. Johnson
Signature Date:  2/18/16


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