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Ownership Document
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| Schema Version: X0306 |
| Document Type: 4 |
| Period of Report: 2/19/20 |
| Not Subject to Section 16: 0 |
| Issuer: |
| Issuer CIK: 1447362 |
| Issuer Name: CASTLE BIOSCIENCES INC |
| Issuer Trading Symbol: CSTL |
| Reporting Owner: |
| Reporting Owner ID: |
| | Owner CIK: 1024008 |
| | Owner Name: KABAKOFF DAVID S |
| Reporting Owner Address: |
| | Owner Street 1: C/O CASTLE BIOSCIENCES, INC. |
| | Owner Street 2: 820 S. FRIENDSWOOD DRIVE, SUITE 201 |
| | Owner City: FRIENDSWOOD |
| | Owner State: TX |
| | Owner ZIP Code: 77546 |
| | Owner State Description: |
| Reporting Owner Relationship: |
| | Is Director? Yes |
| | Is Officer? No |
| | Is Ten Percent Owner? Yes |
| | Is Other? No |
| | Officer Title: |
| | Other Text: |
| Non-Derivative Table: |
| Non-Derivative Transaction: |
| | Security Title: |
| | | Value: Common Stock |
| | Transaction Date: |
| | | Value: 2/19/20 |
| | Transaction Coding: |
| | | Transaction Form Type: 4 |
| | | Transaction Code: S |
| | | Equity Swap Involved? No |
| | | Footnote ID: F1 |
| | Transaction Amounts: |
| | | Transaction Shares: |
| Value: 25,000 |
| | | Transaction Price Per Share: |
| Value: 32.03 |
| | | Transaction Acquired-Disposed Code: |
| Value: D |
| | Post-Transaction Amounts: |
| | | Shares Owned Following Transaction: |
| Value: 1,683,577 |
| | Ownership Nature: |
| | | Direct or Indirect Ownership: |
| Value: I |
| | | Nature of Ownership: |
| Value: By L.P. |
| Footnote ID: F2 |
| Derivative Table: |
| Footnotes: |
| Footnote - F1: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019. |
| Footnote - F2: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein. |
| Remarks: |
| Owner Signature: |
| Signature Name: /s/ Greg Acosta, Attorney-in-fact |
| Signature Date: 2/21/20 |
