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| <?xml version="1.0" encoding="windows-1252"?> |
| <ownershipDocument> |
| <schemaVersion> X0206 </schemaVersion> |
| <documentType> 3/A </documentType> |
| <periodOfReport> 2019-12-19 </periodOfReport> |
| <dateOfOriginalSubmission> 2020-01-06 </dateOfOriginalSubmission> |
| <noSecuritiesOwned> 0 </noSecuritiesOwned> |
| <issuer> |
| | <issuerCik> 0001553643 </issuerCik> |
| | <issuerName> RELMADA THERAPEUTICS, INC. </issuerName> |
| | <issuerTradingSymbol> RLMD </issuerTradingSymbol> |
| | </issuer> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001644079 </rptOwnerCik> |
| | | <rptOwnerName> GLASSPOOL JOHN </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O RELMADA THERAPEUTICS, INC. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 880 THIRD AVENUE, 12TH FLOOR </rptOwnerStreet2> |
| | | <rptOwnerCity> NEW YORK </rptOwnerCity> |
| | | <rptOwnerState> NY </rptOwnerState> |
| | | <rptOwnerZipCode> 10022 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 1 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 0 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle></officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <derivativeTable> |
| | <derivativeHolding> |
| | | <securityTitle> |
| <value> Options to purchase common stock </value> |
| </securityTitle> |
| | | <conversionOrExercisePrice> |
| <value> 43.47 </value> |
| </conversionOrExercisePrice> |
| | | <exerciseDate> |
| <value> 2019-12-19 </value> |
| <footnoteId id="F1"/> |
| </exerciseDate> |
| | | <expirationDate> |
| <value> 2029-12-19 </value> |
| </expirationDate> |
| | | <underlyingSecurity> |
| <underlyingSecurityTitle> |
| <value> Common Stock </value> |
| </underlyingSecurityTitle> |
| <underlyingSecurityShares> |
| <value> 200000 </value> |
| </underlyingSecurityShares> |
| </underlyingSecurity> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </derivativeHolding> |
| | </derivativeTable> |
| <footnotes> |
| | <footnote id="F1"> Options granted on December 19, 2019 to purchase an aggregate of 200,000 shares of common stock. A total of 25% of the options will vest one year from the grant date, and the remaining 75% shall vest in equal quarterly increments of 6.25% of the initial option grant over the following three year period. </footnote> |
| | </footnotes> |
| <remarks> Form 3 amended because inadvertently reported ownership of common stock in form filed on January 6, 2010. </remarks> |
| <ownerSignature> |
| | <signatureName> /s/ John Glasspool </signatureName> |
| | <signatureDate> 2020-01-07 </signatureDate> |
| | </ownerSignature> |
| </ownershipDocument> |
