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<?xml version="1.0" encoding="windows-1252"?> |
<ownershipDocument> |
| <schemaVersion> X0206 </schemaVersion> |
| <documentType> 3 </documentType> |
| <periodOfReport> 2020-06-10 </periodOfReport> |
| <noSecuritiesOwned> 0 </noSecuritiesOwned> |
| <issuer> |
| | <issuerCik> 0001425205 </issuerCik> |
| | <issuerName> IOVANCE BIOTHERAPEUTICS, INC. </issuerName> |
| | <issuerTradingSymbol> IOVA </issuerTradingSymbol> |
| | </issuer> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001659026 </rptOwnerCik> |
| | | <rptOwnerName> Swartzburg Michael </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O IOVANCE BIOTHERAPEUTICS, INC. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 999 SKYWAY ROAD, SUITE 150 </rptOwnerStreet2> |
| | | <rptOwnerCity> SAN CARLOS </rptOwnerCity> |
| | | <rptOwnerState> CA </rptOwnerState> |
| | | <rptOwnerZipCode> 94070 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 0 </isDirector> |
| | | <isOfficer> 1 </isOfficer> |
| | | <isTenPercentOwner> 0 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | <officerTitle> VP, Finance </officerTitle> |
| | | <otherText></otherText> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <derivativeTable> |
| | <derivativeHolding> |
| | | <securityTitle> |
| <value> Stock Option (Right to Buy) </value> |
| </securityTitle> |
| | | <conversionOrExercisePrice> |
| <value> 19.50 </value> |
| </conversionOrExercisePrice> |
| | | <exerciseDate> |
| <footnoteId id="F1"/> |
| </exerciseDate> |
| | | <expirationDate> |
| <value> 2028-03-04 </value> |
| </expirationDate> |
| | | <underlyingSecurity> |
| <underlyingSecurityTitle> |
| <value> Common Stock </value> |
| </underlyingSecurityTitle> |
| <underlyingSecurityShares> |
| <value> 95000 </value> |
| </underlyingSecurityShares> |
| </underlyingSecurity> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </derivativeHolding> |
| | <derivativeHolding> |
| | | <securityTitle> |
| <value> Stock Option (Right to Buy) </value> |
| </securityTitle> |
| | | <conversionOrExercisePrice> |
| <value> 11.26 </value> |
| </conversionOrExercisePrice> |
| | | <exerciseDate> |
| <footnoteId id="F2"/> |
| </exerciseDate> |
| | | <expirationDate> |
| <value> 2029-03-03 </value> |
| </expirationDate> |
| | | <underlyingSecurity> |
| <underlyingSecurityTitle> |
| <value> Common Stock </value> |
| </underlyingSecurityTitle> |
| <underlyingSecurityShares> |
| <value> 35000 </value> |
| </underlyingSecurityShares> |
| </underlyingSecurity> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </derivativeHolding> |
| | <derivativeHolding> |
| | | <securityTitle> |
| <value> Stock Option (Right to Buy) </value> |
| </securityTitle> |
| | | <conversionOrExercisePrice> |
| <value> 23.88 </value> |
| </conversionOrExercisePrice> |
| | | <exerciseDate> |
| <footnoteId id="F3"/> |
| </exerciseDate> |
| | | <expirationDate> |
| <value> 2030-01-19 </value> |
| </expirationDate> |
| | | <underlyingSecurity> |
| <underlyingSecurityTitle> |
| <value> Common Stock </value> |
| </underlyingSecurityTitle> |
| <underlyingSecurityShares> |
| <value> 46500 </value> |
| </underlyingSecurityShares> |
| </underlyingSecurity> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </derivativeHolding> |
| | </derivativeTable> |
| <footnotes> |
| | <footnote id="F1"> Provided the Reporting Person is still employed with the Issuer on the vesting dates, the options are exercisable as follows: (i) options for the purchase of one-third of the granted shares shall vest on the one-year anniversary of March 5, 2018; and (ii) the remaining options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of March 5, 2018. </footnote> |
| | <footnote id="F2"> Provided the Reporting Person is still employed with the Issuer on the vesting dates, the options are exercisable as follows: (i) options for the purchase of one-third of the granted shares shall vest on the one-year anniversary of March 4, 2019; and (ii) the remaining options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of March 4, 2019. </footnote> |
| | <footnote id="F3"> Provided the Reporting Person is still employed with the Issuer on the vesting dates, the options are exercisable as follows: (i) options for the purchase of one-third of the granted shares shall vest on the one-year anniversary of January 20, 2020; and (ii) the remaining options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of January 20, 2020. </footnote> |
| | </footnotes> |
| <ownerSignature> |
| | <signatureName> /s/ Michael C. Swartzburg </signatureName> |
| | <signatureDate> 2020-06-23 </signatureDate> |
| | </ownerSignature> |
| </ownershipDocument> |