As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

 5/24/23  Orbimed Advisors LLC              SC 13D/A               2:119K Prelude Therapeutics Inc.         Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          Orbimed Capital LLC³
 1/14/21‡ Orbimed Advisors LLC              SC 13D/A    1/13/21    3:154K Prelude Therapeutics Inc.         Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          Orbimed Capital LLC³
 10/5/20  Orbimed Advisors LLC              SC 13D                 2:118K Prelude Therapeutics Inc.         Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          Orbimed Capital LLC³

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‡	A non-Insider-Ownership Filing that was accepted after the SEC “closed” at 5:30:00pm ET.  The legal “Filed As Of” date may be the next, or another, day.
¹	Filing/Form Type:
	SC 13D	Statement of Acquisition of Beneficial Ownership by an “Active” Investor — Schedule 13D.
	/A	Amendment to, or Amended version of, a previous Filing of this Type.
³	Group Member:  A Registrant or non-Registrant party to this Filing made by a Group.