As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

12/29/23  Orbimed Advisors LLC              SC 13D/A               2:121K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          OrbiMed Genesis GP LLC³
11/13/23  Orbimed Advisors LLC              SC 13D/A               3:136K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          OrbiMed Genesis GP LLC³
 9/27/22  Orbimed Advisors LLC              SC 13D/A               3:127K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          OrbiMed Genesis GP LLC³
11/12/21  Orbimed Advisors LLC              SC 13D/A               2:104K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          OrbiMed Genesis GP LLC³
12/30/20  Orbimed Advisors LLC              SC 13D/A               2:79K  Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
 7/30/20‡ Orbimed Advisors LLC              SC 13D/A               2:78K  Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
 1/23/19  Orbimed Advisors LLC              SC 13D/A               2:104K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
 1/26/18  Orbimed Advisors LLC              SC 13D/A               2:128K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
 1/26/18‡ Orbimed Advisors LLC              SC 13D/A               2:128K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
  8/3/17  Orbimed Advisors LLC              SC 13D                 3:144K Alpine Immune Sciences, Inc.      Shearman & Sterling LLP  
          OrbiMed Capital GP VI LLC³
          Samuel D. Isaly³

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‡	A non-Insider-Ownership Filing that was accepted after the SEC “closed” at 5:30:00pm ET.  The legal “Filed As Of” date may be the next, or another, day.
¹	Filing/Form Type:
	SC 13D	Statement of Acquisition of Beneficial Ownership by an “Active” Investor — Schedule 13D.
	/A	Amendment to, or Amended version of, a previous Filing of this Type.
³	Group Member:  A Registrant or non-Registrant party to this Filing made by a Group.