As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

 3/12/19  Yu Alice Lin-Tsing                5          Director²   1:6K   Opko Health, Inc.                 DONNELLEY FIN… File16/FA 
  3/1/19  Opko Health, Inc.                 10-K       12/31/18  112:17M                                                             
  1/2/19  Frost Nevada Investments Trust    4          D,O,%Owner² 2:29K  Opko Health, Inc.                 DONNELLEY FIN… File16/FA 
          Frost Phillip MD et al
12/31/18  Frost Nevada Investments Trust    4          D,O,%Owner² 2:24K  Opko Health, Inc.                 DONNELLEY FIN… File16/FA 
          Frost Phillip MD et al

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¹	Filing/Form Types:
	4	Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 4 { The Filer is an Insider² of the Issuer }.
	5	Annual Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 5 { The Filer is an Insider² of the Issuer }.
	10-K	Annual Report — Form 10-K.
²	Insider:  The Filer is a Director, Officer, 10% Owner and/or Other “insider” of the Issuer.