2/20/09 Voya VARIABLE PORTFOLIOS Inc. 485BPOS 2/20/09 11:7.4M Toppan Merrill/FA → ING BlackRock Science & Technology Opportunities Portfolio → ING Opportunistic LargeCap Portfolio → ING Russell Global Large Cap Index 75% Portfolio → Voya Global High Dividend Low Volatility Portfolio → Voya Index Plus LargeCap Portfolio → Voya Index Plus MidCap Portfolio → Voya Index Plus SmallCap Portfolio → Voya International Index Portfolio → Voya RussellTM Large Cap Index Portfolio → Voya RussellTM Mid Cap Index Portfolio → Voya RussellTM Small Cap Index Portfolio → Voya Small Co. Portfolio → Voya U.S. Bond Index Portfolio 2/20/09 Voya VARIABLE PORTFOLIOS Inc. 497 2/20/09 1:13K Toppan Merrill/FA → Voya Index Plus LargeCap Portfolio → Voya Index Plus MidCap Portfolio → Voya Index Plus SmallCap Portfolio ING Series Fund Inc. → ING Index Plus LargeCap Fund → ING Index Plus SmallCap Fund → Voya Mid Cap Research Enhanced Index Fund