As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

 3/11/11  Frost Phillip MD et al            4          D,O,%Owner² 2:23K  Opko Health, Inc.                 DONNELLEY FIN… File16/FA 
          Frost Gamma Investments Trust
 3/10/11  Frost Phillip MD et al            4          D,O,%Owner² 2:8K   Opko Health, Inc.                 DONNELLEY FIN… File16/FA 
          Frost Gamma Investments Trust
 3/10/11‡ Opko Health, Inc.                 8-K:1,7,9    3/9/11    4:215K                                   Donnelley … Solutions/FA 
 3/10/11‡ Opko Health, Inc.                 424B5                  1:505K                                   Donnelley … Solutions/FA 

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‡	A non-Insider-Ownership Filing that was accepted after the SEC “closed” at 5:30:00pm ET.  The legal “Filed As Of” date may be the next, or another, day.
¹	Filing/Form Types:
	4	Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 4 { The Filer is an Insider² of the Issuer }.
	8-K	Current Report — Form 8-K { Item 1: Business & Operations;  2: Financial Info;  3: Securities & Trading;  4: Accountants & Accounting;  5: Governance & Management;  6: Asset-Backed Securities;  7: Disclosures;  8: Events;  9: Financials }.
	424B5	Prospectus – Primary Offering or Shelf Securities – New Facts or Events.
²	Insider:  The Filer is a Director, Officer, 10% Owner and/or Other “insider” of the Issuer.