SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Cerner Corp. – ‘10-Q’ for 3/31/22 – ‘EX-101.DEF’

On:  Tuesday, 5/3/22, at 9:07am ET   ·   For:  3/31/22   ·   Accession #:  804753-22-24   ·   File #:  0-15386

Previous ‘10-Q’:  ‘10-Q’ on 10/29/21 for 9/30/21   ·   Latest ‘10-Q’:  This Filing   ·   1 Reference:  To:  Cerner Corp. – ‘SC 14D9’ on 1/19/22

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 5/03/22  Cerner Corp.                      10-Q        3/31/22   74:6.2M

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    621K 
 2: EX-10.2     Material Contract                                   HTML     33K 
 3: EX-10.3     Material Contract                                   HTML     33K 
 4: EX-10.4     Material Contract                                   HTML     39K 
 5: EX-10.5     Material Contract                                   HTML     26K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     25K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     25K 
 8: EX-32.1     Certification -- §906 - SOA'02                      HTML     21K 
 9: EX-32.2     Certification -- §906 - SOA'02                      HTML     21K 
15: R1          Document And Entity Information                     HTML     73K 
16: R2          Consolidated Balance Sheets                         HTML    144K 
17: R3          Consolidated Statements Of Operations               HTML     85K 
18: R4          Consolidated Statements Of Comprehensive Income     HTML     44K 
19: R5          Consolidated Statements Of Cash Flows               HTML    103K 
20: R6          Consolidated Statements of Changes in               HTML     70K 
                Shareholders' Equity Statement                                   
21: R7          Supplemental Cash Flow Information                  HTML     29K 
22: R8          Consolidated Statements Of Operations               HTML     20K 
                (Parenthetical)                                                  
23: R9          Consolidated Statements Of Comprehensive Income     HTML     28K 
                (Parenthetical)                                                  
24: R10         Supplemental Cash Flow Information details          HTML     31K 
25: R11         Interim Statement Presentation (Notes)              HTML     53K 
26: R12         Revenue from Contracts with Customers (Notes)       HTML     65K 
27: R13         Receivables                                         HTML     38K 
28: R14         Investments                                         HTML     77K 
29: R15         Debt                                                HTML     42K 
30: R16         Fair Value Measurements                             HTML     59K 
31: R17         Income Taxes                                        HTML     24K 
32: R18         Earnings Per Share                                  HTML     40K 
33: R19         Share-Based Compensation                            HTML     90K 
34: R20         Contingencies                                       HTML     29K 
35: R21         Segment Reporting                                   HTML     56K 
36: R22         Organization, Consolidation and Presentation of     HTML     21K 
                Financial Statements (Policies)                                  
37: R23         Revenue from Contracts with Customers (Tables)      HTML     60K 
38: R24         Receivables (Tables)                                HTML     38K 
39: R25         Investments (Tables)                                HTML     74K 
40: R26         Debt (Tables)                                       HTML     36K 
41: R27         Fair Value Measurements (Tables)                    HTML     54K 
42: R28         Earnings Per Share (Tables)                         HTML     39K 
43: R29         Share-Based Compensation (Tables)                   HTML     97K 
44: R30         Segment Reporting (Tables)                          HTML     51K 
45: R31         Policies (Details)                                  HTML     25K 
46: R32         Interim Statement Presentation (Details)            HTML     23K 
47: R33         Disaggregation of Revenue (Details)                 HTML     71K 
48: R34         Performance Obligation (Details)                    HTML     26K 
49: R35         Revenue from Contracts with Customers (Details)     HTML     22K 
50: R36         Receivables (Narrative) (Details)                   HTML     24K 
51: R37         Receivables (Summary Of Net Receivables) (Details)  HTML     28K 
52: R38         Schedule of Valuation and Qualifying Accounts       HTML     33K 
                (Details)                                                        
53: R39         Investments (Narrative) (Details)                   HTML     27K 
54: R40         Investments (Details)                               HTML     55K 
55: R41         Schedule of Indebtedness Outstanding (Details)      HTML     51K 
56: R42         Indebtedness (Narrative) (Details)                  HTML     37K 
57: R43         Fair Value Measurements (Narrative) (Details)       HTML     27K 
58: R44         Fair Value Measurements Fair Value, Assets and      HTML     57K 
                Liabilities Measured at Fair Value on a Recurring                
                Basis (Details)                                                  
59: R45         Income Taxes (Details)                              HTML     21K 
60: R46         Earnings Per Share (Reconciliation Of The           HTML     50K 
                Numerators And The Denominators Of The Basic And                 
                Diluted Per Share) (Details)                                     
61: R47         Earnings Per Share (Narrative) (Details)            HTML     27K 
62: R48         Share-Based Compensation (Schedule Of Stock         HTML     50K 
                Options Activity) (Details)                                      
63: R49         Share-Based Compensation (Schedule Of Non-Vested    HTML     42K 
                Shares Activity) (Details)                                       
64: R50         Share-Based Compensation (Compensation Expense      HTML     32K 
                Recognized In The Condensed Consolidated                         
                Statements Of Operations) (Details)                              
65: R51         Schedule of Accumulated Other Comprehensive Income  HTML     40K 
                (Loss) (Details)                                                 
66: R52         Reclassification out of Accumulated Other           HTML     47K 
                Comprehensive Income (Details)                                   
67: R53         Share-Based Compensation (Narrative) (Details)      HTML     42K 
68: R54         Contingencies Contingencies (Details)               HTML     34K 
69: R55         Segment Reporting (Summary Of The Operating         HTML     48K 
                Information) (Details)                                           
72: XML         IDEA XML File -- Filing Summary                      XML    124K 
70: XML         XBRL Instance -- cern-20220331_htm                   XML   1.55M 
71: EXCEL       IDEA Workbook of Financial Reports                  XLSX     74K 
11: EX-101.CAL  XBRL Calculations -- cern-20220331_cal               XML    133K 
12: EX-101.DEF  XBRL Definitions -- cern-20220331_def                XML    471K 
13: EX-101.LAB  XBRL Labels -- cern-20220331_lab                     XML   1.10M 
14: EX-101.PRE  XBRL Presentations -- cern-20220331_pre              XML    645K 
10: EX-101.SCH  XBRL Schema -- cern-20220331                         XSD    110K 
73: JSON        XBRL Instance as JSON Data -- MetaLinks              330±   454K 
74: ZIP         XBRL Zipped Folder -- 0000804753-22-000024-xbrl      Zip    262K

‘EX-101.DEF’   —   XBRL Definitions — cern-20220331_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- Copyright 2022 Workiva -->
<!-- r:589755ca-ad4f-41bb-ac0b-4710a569d4b1,g:96e8622d-97c5-48ab-8780-b3b737a12091 -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
<link:roleRef roleURI="http://www.cerner.com/role/DocumentAndEntityInformation" xlink:type="simple" xlink:href="cern-20220331.xsd#DocumentAndEntityInformation"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/DocumentAndEntityInformation" xlink:type="extended" id="ifc4aa329e8d54e5c9b262d4a2982202f_DocumentAndEntityInformation">
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_1216c84b-cbee-4bc6-8adf-ec82cdaf4088" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentType_1216c84b-cbee-4bc6-8adf-ec82cdaf4088" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_88ab5969-9884-4a43-b96c-2c0c8ff2d512" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentQuarterlyReport"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentQuarterlyReport_88ab5969-9884-4a43-b96c-2c0c8ff2d512" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_54e4e708-d9d8-408a-a9fa-2dc4b0484335" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentPeriodEndDate_54e4e708-d9d8-408a-a9fa-2dc4b0484335" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_b8a052be-e550-40cf-a0c7-9040e8cb28e5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentTransitionReport"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentTransitionReport_b8a052be-e550-40cf-a0c7-9040e8cb28e5" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_ec8f878d-57d2-4ea3-b595-bd90ed17aac6" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityFileNumber_ec8f878d-57d2-4ea3-b595-bd90ed17aac6" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_7cb493ae-7290-4da5-b88f-8592195d4370" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityRegistrantName_7cb493ae-7290-4da5-b88f-8592195d4370" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_b8cbe34c-4593-4b4e-a5d4-cae420b338d9" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityIncorporationStateCountryCode_b8cbe34c-4593-4b4e-a5d4-cae420b338d9" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_cc1d02ac-e0b6-419f-bf88-7cd6fd0f38e0" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityAddressAddressLine1_cc1d02ac-e0b6-419f-bf88-7cd6fd0f38e0" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_acf5d87a-f57f-4991-8b11-d5e8be2719fe" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityAddressCityOrTown_acf5d87a-f57f-4991-8b11-d5e8be2719fe" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_2d8e36c6-f6f0-4167-9e28-09f0ddfa9dea" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityAddressStateOrProvince_2d8e36c6-f6f0-4167-9e28-09f0ddfa9dea" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_be129ef6-cb77-45e0-9876-ccfe2ed995f5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityTaxIdentificationNumber_be129ef6-cb77-45e0-9876-ccfe2ed995f5" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_c086bb70-eb71-4b48-8aea-3629f28058d4" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityAddressPostalZipCode_c086bb70-eb71-4b48-8aea-3629f28058d4" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_31d50e0f-a8a7-4ade-9583-ec084895d545" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_CityAreaCode_31d50e0f-a8a7-4ade-9583-ec084895d545" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_da87cd72-25df-4790-882a-c707ff4097c8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_LocalPhoneNumber_da87cd72-25df-4790-882a-c707ff4097c8" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_5a4152f4-57d7-4000-809c-9b90997d2605" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_Security12bTitle_5a4152f4-57d7-4000-809c-9b90997d2605" xlink:type="arc" order="14"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_2a631ed0-b8a5-4609-94a1-02563fa47e09" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_TradingSymbol_2a631ed0-b8a5-4609-94a1-02563fa47e09" xlink:type="arc" order="15"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_bd23109f-e668-4aeb-aa1b-9bdce421b68a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SecurityExchangeName"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_SecurityExchangeName_bd23109f-e668-4aeb-aa1b-9bdce421b68a" xlink:type="arc" order="16"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_5265d65a-3509-4fd5-bf27-5e8ca519bbc3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCurrentReportingStatus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityCurrentReportingStatus_5265d65a-3509-4fd5-bf27-5e8ca519bbc3" xlink:type="arc" order="17"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_6aaa31d7-7177-4a9b-b26c-c485d3424a87" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInteractiveDataCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityInteractiveDataCurrent_6aaa31d7-7177-4a9b-b26c-c485d3424a87" xlink:type="arc" order="18"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_e0e93b45-50a9-4930-b454-7b74a9764427" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFilerCategory"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityFilerCategory_e0e93b45-50a9-4930-b454-7b74a9764427" xlink:type="arc" order="19"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_ff2eedfe-c1c9-43b3-887e-574cafdf5ce9" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitySmallBusiness"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntitySmallBusiness_ff2eedfe-c1c9-43b3-887e-574cafdf5ce9" xlink:type="arc" order="20"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_3d7c92ad-f2ac-43c6-98f1-d2427f54e754" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityEmergingGrowthCompany_3d7c92ad-f2ac-43c6-98f1-d2427f54e754" xlink:type="arc" order="21"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_c03da544-a09f-4afd-8c83-f5a8126da21d" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityShellCompany"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityShellCompany_c03da544-a09f-4afd-8c83-f5a8126da21d" xlink:type="arc" order="22"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_ffa1870c-0256-444b-91d4-495fe88f56b5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCommonStockSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_ffa1870c-0256-444b-91d4-495fe88f56b5" xlink:type="arc" order="23"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_2d10888d-8c50-463b-9880-dd0baeb277a9" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntityCentralIndexKey_2d10888d-8c50-463b-9880-dd0baeb277a9" xlink:type="arc" order="24"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_e7cb720f-bcac-4759-b1db-3ed64dd4a337" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_AmendmentFlag_e7cb720f-bcac-4759-b1db-3ed64dd4a337" xlink:type="arc" order="25"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_47d51677-0dc4-4515-b062-038fd6a20d2b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentFiscalYearFocus_47d51677-0dc4-4515-b062-038fd6a20d2b" xlink:type="arc" order="26"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_2ac8bb3a-f0fb-4dfd-987e-15fd567d1e38" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_DocumentFiscalPeriodFocus_2ac8bb3a-f0fb-4dfd-987e-15fd567d1e38" xlink:type="arc" order="27"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_0e684d87-0f68-4427-8ff0-f68bc3391383" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_CurrentFiscalYearEndDate_0e684d87-0f68-4427-8ff0-f68bc3391383" xlink:type="arc" order="28"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_f097c1f5-91d4-46e3-bf09-f9082ea65061" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitiesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_8e185ddc-79f5-4ebc-a148-b6dd011cb60f" xlink:to="loc_dei_EntitiesTable_f097c1f5-91d4-46e3-bf09-f9082ea65061" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LegalEntityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_f097c1f5-91d4-46e3-bf09-f9082ea65061" xlink:to="loc_dei_LegalEntityAxis_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48_default" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48" xlink:to="loc_dei_EntityDomain_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_94aeb9d3-1cbd-44d6-8dc5-d35cbd0866c7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_ebf65df0-6f2f-4aa7-a88c-2afbb9f27e48" xlink:to="loc_dei_EntityDomain_94aeb9d3-1cbd-44d6-8dc5-d35cbd0866c7" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="cern-20220331.xsd#ConsolidatedBalanceSheets"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ConsolidatedBalanceSheets" xlink:type="extended" id="i01bbb200851646a9b706b3f4520c7333_ConsolidatedBalanceSheets">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_145cb4da-aad0-4254-9e3a-30733ab067aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_145cb4da-aad0-4254-9e3a-30733ab067aa" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_9e41cae2-3057-4bb4-a3b5-a11da58b379a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_9e41cae2-3057-4bb4-a3b5-a11da58b379a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_920c5850-1f11-47bd-aa73-60241aaba1e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_ReceivablesNetCurrent_920c5850-1f11-47bd-aa73-60241aaba1e1" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_f8d354dd-b6ef-4072-a30a-43017e877f69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_InventoryNet_f8d354dd-b6ef-4072-a30a-43017e877f69" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d4032717-fd32-43b0-9cf7-6db7412f870f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d4032717-fd32-43b0-9cf7-6db7412f870f" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_34b79898-bad9-4a45-b93c-fd13c4492520" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_a1e6e9a4-87db-4bed-95a1-1a22024ba7e4" xlink:to="loc_us-gaap_AssetsCurrent_34b79898-bad9-4a45-b93c-fd13c4492520" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_bc05b2b8-bf9c-4127-9856-95de5ec5108c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_bc05b2b8-bf9c-4127-9856-95de5ec5108c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_e4582765-d8c7-4d9c-8d97-74a7432705c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_e4582765-d8c7-4d9c-8d97-74a7432705c8" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareNet_9c42b5a7-77d3-4ba2-985a-0109854168ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CapitalizedComputerSoftwareNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareNet_9c42b5a7-77d3-4ba2-985a-0109854168ac" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_f075c754-2c70-4fb5-aa34-7926bd9467c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_Goodwill_f075c754-2c70-4fb5-aa34-7926bd9467c7" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a7571f30-fb1d-4fc1-a748-1e249e6a6327" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a7571f30-fb1d-4fc1-a748-1e249e6a6327" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_1ad27dfe-af31-4915-911a-5de30dfe5b07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_LongTermInvestments_1ad27dfe-af31-4915-911a-5de30dfe5b07" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_f3a854f2-0f0b-4de9-9a5f-dc9fab604f02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_f3a854f2-0f0b-4de9-9a5f-dc9fab604f02" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8322a0b9-fc74-4385-b263-385575d1567b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_a3afc601-f852-464c-97d6-34f7f936215a" xlink:to="loc_us-gaap_Assets_8322a0b9-fc74-4385-b263-385575d1567b" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_b7a0e3b8-0dcb-49eb-be00-f294950a7125" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_AccountsPayableCurrent_b7a0e3b8-0dcb-49eb-be00-f294950a7125" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_a68d2662-f622-4c26-a4f2-69826cd0cf37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_LongTermDebtCurrent_a68d2662-f622-4c26-a4f2-69826cd0cf37" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_89a1bf72-bcc8-4891-9d00-54d056bf8302" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRevenueCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_DeferredRevenueCurrent_89a1bf72-bcc8-4891-9d00-54d056bf8302" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_2e5f72db-febc-454b-a996-a31b1c56601b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_2e5f72db-febc-454b-a996-a31b1c56601b" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_884bcf32-e80d-4224-8870-4ded27769081" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_884bcf32-e80d-4224-8870-4ded27769081" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_1ce2c16a-834d-485e-a71d-59055dd08dd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_bb3b8683-030d-4152-a67f-2787874d720d" xlink:to="loc_us-gaap_LiabilitiesCurrent_1ce2c16a-834d-485e-a71d-59055dd08dd3" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_1ec0e0fc-393f-40db-8b86-f0f119d2d5fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_1ec0e0fc-393f-40db-8b86-f0f119d2d5fc" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_c3aa051f-10c2-4ad4-b105-cd6a2f27c83d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_c3aa051f-10c2-4ad4-b105-cd6a2f27c83d" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_28d1e0c1-2a34-4547-8bd6-8c14c35552d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_28d1e0c1-2a34-4547-8bd6-8c14c35552d3" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f9d53f14-fc9a-4da3-a393-0fa429be7218" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_Liabilities_f9d53f14-fc9a-4da3-a393-0fa429be7218" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_0a350ca0-c54d-4ae8-bc24-23409d09c790" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_CommonStockValue_0a350ca0-c54d-4ae8-bc24-23409d09c790" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_4dbb4c57-f796-41c7-bece-56bf5014b2b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_4dbb4c57-f796-41c7-bece-56bf5014b2b7" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_af360e3a-add5-4daa-870e-b0099a5bcb2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_af360e3a-add5-4daa-870e-b0099a5bcb2a" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_02ddf343-70e1-401a-b808-1f80eefd378b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_TreasuryStockValue_02ddf343-70e1-401a-b808-1f80eefd378b" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ff5a2c4a-ab4b-40be-9926-bd043faa65e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ff5a2c4a-ab4b-40be-9926-bd043faa65e1" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8af288b8-9ab6-4cb9-b9fd-eeb98240ebe3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_3b636ee4-fc03-49fc-a491-0182b1beb7e2" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8af288b8-9ab6-4cb9-b9fd-eeb98240ebe3" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_4859c2f8-f1e2-45c3-b660-6a3ffd123f8d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d614befd-685a-4aaf-a8e6-774def3c0d1d" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_4859c2f8-f1e2-45c3-b660-6a3ffd123f8d" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_c689a9d1-220a-4426-b5e2-8f5cd158c1e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_c689a9d1-220a-4426-b5e2-8f5cd158c1e6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_7a92c261-6c44-4625-a0af-534cfd9b86c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_7a92c261-6c44-4625-a0af-534cfd9b86c7" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_9c4c6e8f-d2a0-446e-a822-5105acc09aec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_CommonStockSharesIssued_9c4c6e8f-d2a0-446e-a822-5105acc09aec" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockShares_420f0a4e-882c-4f62-9760-775b78deeabb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockShares"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_TreasuryStockShares_420f0a4e-882c-4f62-9760-775b78deeabb" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_fa9ece68-f24b-4dc0-ba3b-24b50a154f53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_96b89078-1ab1-4574-9ded-6158b02eecf6" xlink:to="loc_us-gaap_StatementTable_fa9ece68-f24b-4dc0-ba3b-24b50a154f53" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_0a1824c9-aec5-4fc4-843d-588cba60266d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_fa9ece68-f24b-4dc0-ba3b-24b50a154f53" xlink:to="loc_srt_StatementScenarioAxis_0a1824c9-aec5-4fc4-843d-588cba60266d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_0a1824c9-aec5-4fc4-843d-588cba60266d_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_0a1824c9-aec5-4fc4-843d-588cba60266d" xlink:to="loc_srt_ScenarioUnspecifiedDomain_0a1824c9-aec5-4fc4-843d-588cba60266d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_28df3ba4-c8d5-4a5c-9d6f-1540373026e9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_0a1824c9-aec5-4fc4-843d-588cba60266d" xlink:to="loc_srt_ScenarioUnspecifiedDomain_28df3ba4-c8d5-4a5c-9d6f-1540373026e9" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ConsolidatedStatementsOfOperations" xlink:type="simple" xlink:href="cern-20220331.xsd#ConsolidatedStatementsOfOperations"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ConsolidatedStatementsOfOperations" xlink:type="extended" id="i420f3c77837f403399cac161bd6325c5_ConsolidatedStatementsOfOperations">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_4d994a78-9e4f-4cb5-adb8-2dffab8c4ff1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_Revenues_4d994a78-9e4f-4cb5-adb8-2dffab8c4ff1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpensesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_181e3004-7031-490f-97bf-01362567c58a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_181e3004-7031-490f-97bf-01362567c58a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SalesAndClientServicesExpense_6635b39b-8209-4b12-b29d-2dcb5df9c8c8" xlink:href="cern-20220331.xsd#cern_SalesAndClientServicesExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_cern_SalesAndClientServicesExpense_6635b39b-8209-4b12-b29d-2dcb5df9c8c8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_c87903d5-22f3-4d70-b1df-573ac2277670" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_c87903d5-22f3-4d70-b1df-573ac2277670" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_68c6b1bd-a99c-492c-8b6c-f71129384131" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_68c6b1bd-a99c-492c-8b6c-f71129384131" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_Amortizationofacquisitionrelatedintangibles_d6bb79b8-6aa0-4064-a5b1-888c16a05fb2" xlink:href="cern-20220331.xsd#cern_Amortizationofacquisitionrelatedintangibles"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_cern_Amortizationofacquisitionrelatedintangibles_d6bb79b8-6aa0-4064-a5b1-888c16a05fb2" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_439c5082-ee0e-44b5-bd8c-be1eef28e26c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_2cbd0e04-4f5d-4d61-a1cc-cb00d6c0e343" xlink:to="loc_us-gaap_CostsAndExpenses_439c5082-ee0e-44b5-bd8c-be1eef28e26c" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_99641823-8cfe-4667-87f6-21b9b7e4e17a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_OperatingIncomeLoss_99641823-8cfe-4667-87f6-21b9b7e4e17a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_c9122c60-d02e-4864-8696-c3e976ccb036" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_c9122c60-d02e-4864-8696-c3e976ccb036" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_48b13632-9d98-46da-8dbf-26cb23157518" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_48b13632-9d98-46da-8dbf-26cb23157518" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_b5409241-21a2-4044-9236-2e2ab51299b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_b5409241-21a2-4044-9236-2e2ab51299b1" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_27c784cb-220b-4635-8599-1b4951764172" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_NetIncomeLoss_27c784cb-220b-4635-8599-1b4951764172" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_765f79c8-f8f5-4f2a-a07f-9140aea95494" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_EarningsPerShareBasic_765f79c8-f8f5-4f2a-a07f-9140aea95494" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_84ae664c-19b5-4cb9-93ad-ad47f2a6412f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_EarningsPerShareDiluted_84ae664c-19b5-4cb9-93ad-ad47f2a6412f" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_d8649fa5-3cb4-4671-bcdb-7508cae90855" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_d8649fa5-3cb4-4671-bcdb-7508cae90855" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_04aa2c8f-6b88-41d6-9125-ee08f7bc1618" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_04aa2c8f-6b88-41d6-9125-ee08f7bc1618" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_55933a79-3fc3-4f28-aeee-9fe57f550407" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_40a7e7c0-7692-476f-8199-2f7d405acba3" xlink:to="loc_us-gaap_StatementTable_55933a79-3fc3-4f28-aeee-9fe57f550407" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_1357be35-3a8c-4c19-b438-b3e105a50bea" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_55933a79-3fc3-4f28-aeee-9fe57f550407" xlink:to="loc_srt_StatementScenarioAxis_1357be35-3a8c-4c19-b438-b3e105a50bea" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_1357be35-3a8c-4c19-b438-b3e105a50bea_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_1357be35-3a8c-4c19-b438-b3e105a50bea" xlink:to="loc_srt_ScenarioUnspecifiedDomain_1357be35-3a8c-4c19-b438-b3e105a50bea_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_4f469d9a-2ca4-4425-a0a8-a4c7a6b047a6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_1357be35-3a8c-4c19-b438-b3e105a50bea" xlink:to="loc_srt_ScenarioUnspecifiedDomain_4f469d9a-2ca4-4425-a0a8-a4c7a6b047a6" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ConsolidatedStatementsOfOperationsParenthetical" xlink:type="simple" xlink:href="cern-20220331.xsd#ConsolidatedStatementsOfOperationsParenthetical"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ConsolidatedStatementsOfOperationsParenthetical" xlink:type="extended" id="i7c8b512f16ce45eda43faf1d72dff6d8_ConsolidatedStatementsOfOperationsParenthetical">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_c0a3ec14-1646-48ab-9877-02b985c9d014" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareAmortization1_30dd252d-40d9-4edc-8819-a7fbd57992b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CapitalizedComputerSoftwareAmortization1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_c0a3ec14-1646-48ab-9877-02b985c9d014" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareAmortization1_30dd252d-40d9-4edc-8819-a7fbd57992b8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ecdbb139-3a92-4455-815a-0cb12c918d17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_c0a3ec14-1646-48ab-9877-02b985c9d014" xlink:to="loc_us-gaap_StatementTable_ecdbb139-3a92-4455-815a-0cb12c918d17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RestatementAxis_4e38e16e-b59f-4f47-9e19-a023ac933863" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RestatementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ecdbb139-3a92-4455-815a-0cb12c918d17" xlink:to="loc_srt_RestatementAxis_4e38e16e-b59f-4f47-9e19-a023ac933863" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_4e38e16e-b59f-4f47-9e19-a023ac933863_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RestatementDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RestatementAxis_4e38e16e-b59f-4f47-9e19-a023ac933863" xlink:to="loc_srt_RestatementDomain_4e38e16e-b59f-4f47-9e19-a023ac933863_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_ad3dc834-5676-4202-92c7-4fe96041eb6f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RestatementDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RestatementAxis_4e38e16e-b59f-4f47-9e19-a023ac933863" xlink:to="loc_srt_RestatementDomain_ad3dc834-5676-4202-92c7-4fe96041eb6f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_d8865141-d9de-44ac-9c74-540e89c063d1" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ecdbb139-3a92-4455-815a-0cb12c918d17" xlink:to="loc_srt_ProductOrServiceAxis_d8865141-d9de-44ac-9c74-540e89c063d1" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d8865141-d9de-44ac-9c74-540e89c063d1_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_d8865141-d9de-44ac-9c74-540e89c063d1" xlink:to="loc_srt_ProductsAndServicesDomain_d8865141-d9de-44ac-9c74-540e89c063d1_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c1a7dea6-9474-43e2-9fa3-974a2b15ac96" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_d8865141-d9de-44ac-9c74-540e89c063d1" xlink:to="loc_srt_ProductsAndServicesDomain_c1a7dea6-9474-43e2-9fa3-974a2b15ac96" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="cern-20220331.xsd#ConsolidatedStatementsOfCashFlows"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended" id="i2480ca45c512478b9ff0e806c1a04e0d_ConsolidatedStatementsOfCashFlows">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_71ee2bc8-01af-4cb7-a218-a403013a16cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_71ee2bc8-01af-4cb7-a218-a403013a16cc" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b0d07b95-57fd-4625-bcd0-a196722bfbb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_71ee2bc8-01af-4cb7-a218-a403013a16cc" xlink:to="loc_us-gaap_NetIncomeLoss_b0d07b95-57fd-4625-bcd0-a196722bfbb9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_71ee2bc8-01af-4cb7-a218-a403013a16cc" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_769bc84b-13b0-4306-aee0-e03e1f51e044" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_769bc84b-13b0-4306-aee0-e03e1f51e044" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_99b4dfc6-c5b9-47b3-825c-48687690f680" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:to="loc_us-gaap_ShareBasedCompensation_99b4dfc6-c5b9-47b3-825c-48687690f680" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_7735459b-765d-494f-97dc-9b6114b15acd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_7735459b-765d-494f-97dc-9b6114b15acd" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_51cd4047-1ae4-4562-87a8-e846bad27d60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_51cd4047-1ae4-4562-87a8-e846bad27d60" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_378031d1-2e10-4d30-a488-bcd5699e7787" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_378031d1-2e10-4d30-a488-bcd5699e7787" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_e29d0c0a-73fe-4e3d-b37f-b28cfe9f9f83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_e29d0c0a-73fe-4e3d-b37f-b28cfe9f9f83" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_00cc5ebf-2b51-49ec-abf3-b9007275538f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_00cc5ebf-2b51-49ec-abf3-b9007275538f" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_c0d62843-ba5a-44b3-aa84-4a8a09d29851" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_c0d62843-ba5a-44b3-aa84-4a8a09d29851" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_888c9a73-fd33-47be-9d94-e012043cd864" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_888c9a73-fd33-47be-9d94-e012043cd864" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_79a8bc83-bcc4-4721-9cfe-df425ed3250d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8bf19eec-db31-45bd-8f61-7b0fa6f2ef7b" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_79a8bc83-bcc4-4721-9cfe-df425ed3250d" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2c1d27a6-0723-4ae7-bc9b-805f8e404db0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_fad6b57e-5561-457d-adba-c57e1f33670b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2c1d27a6-0723-4ae7-bc9b-805f8e404db0" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07502119-4735-4b67-9c3f-5de65b7c6652" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07502119-4735-4b67-9c3f-5de65b7c6652" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToDevelopSoftware_a68d6abf-c4e5-4a5b-b69d-9703af59135e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToDevelopSoftware"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_PaymentsToDevelopSoftware_a68d6abf-c4e5-4a5b-b69d-9703af59135e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_043a3451-a0e6-47c6-af50-e68291332c22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_043a3451-a0e6-47c6-af50-e68291332c22" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_95dbb867-24c9-45d3-ad63-f0441e31e709" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_95dbb867-24c9-45d3-ad63-f0441e31e709" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_8063a06d-4e45-47da-9f4b-a97fdbff5c35" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_8063a06d-4e45-47da-9f4b-a97fdbff5c35" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_64062980-8a7e-4b43-858c-7c7dd9c9917e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f1c53915-0d5a-4a89-a2af-f33a5e160b8a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_64062980-8a7e-4b43-858c-7c7dd9c9917e" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_61e3d255-4375-4e50-aa45-eaefff706de6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_61e3d255-4375-4e50-aa45-eaefff706de6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_4fa2d6e1-0d04-4f49-bc5a-93ea008c842e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_4fa2d6e1-0d04-4f49-bc5a-93ea008c842e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_847785f7-3249-4b10-9c9f-ad28c60ddd28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_847785f7-3249-4b10-9c9f-ad28c60ddd28" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_c3d9c7dc-fae8-442a-acf7-c927043f76ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_c3d9c7dc-fae8-442a-acf7-c927043f76ae" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_874845ba-fd7c-49a8-8762-55811267e611" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_874845ba-fd7c-49a8-8762-55811267e611" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_b747eb13-e856-4fd2-995a-42f141070913" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividends"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_PaymentsOfDividends_b747eb13-e856-4fd2-995a-42f141070913" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_4cb7c941-c687-4981-8a6d-3ae03ca7f18c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_4cb7c941-c687-4981-8a6d-3ae03ca7f18c" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c5feef0-65da-4928-9a35-c2adc5ebbcb3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_488d9acb-6c70-4bf2-8f82-ae5687cf548e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c5feef0-65da-4928-9a35-c2adc5ebbcb3" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_b249a019-2e9d-491b-a79c-a1fb23cea963" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_b249a019-2e9d-491b-a79c-a1fb23cea963" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_aa616a61-afaf-4498-8949-d5f7572e1ba1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_aa616a61-afaf-4498-8949-d5f7572e1ba1" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1b30a119-2ac8-440e-977d-2b2152149f15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1b30a119-2ac8-440e-977d-2b2152149f15" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_07d9b8bc-5a0e-4f1f-810d-7fd4411e461a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_9ba389d1-b610-4073-915d-608ae6ee0049" xlink:to="loc_us-gaap_StatementTable_07d9b8bc-5a0e-4f1f-810d-7fd4411e461a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_e35bf1b8-080d-4f31-a44a-83c81e248fb8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_07d9b8bc-5a0e-4f1f-810d-7fd4411e461a" xlink:to="loc_srt_StatementScenarioAxis_e35bf1b8-080d-4f31-a44a-83c81e248fb8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_e35bf1b8-080d-4f31-a44a-83c81e248fb8_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_e35bf1b8-080d-4f31-a44a-83c81e248fb8" xlink:to="loc_srt_ScenarioUnspecifiedDomain_e35bf1b8-080d-4f31-a44a-83c81e248fb8_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_53b5ac8b-7bba-441a-b1ab-9095dfc919bf" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_e35bf1b8-080d-4f31-a44a-83c81e248fb8" xlink:to="loc_srt_ScenarioUnspecifiedDomain_53b5ac8b-7bba-441a-b1ab-9095dfc919bf" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ConsolidatedStatementsofChangesinShareholdersEquityStatement" xlink:type="simple" xlink:href="cern-20220331.xsd#ConsolidatedStatementsofChangesinShareholdersEquityStatement"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ConsolidatedStatementsofChangesinShareholdersEquityStatement" xlink:type="extended" id="ibe08b36fc0c349db80e3f0ff414da6d6_ConsolidatedStatementsofChangesinShareholdersEquityStatement">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_c27d6925-7844-49fd-909d-484d987fc864" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_c27d6925-7844-49fd-909d-484d987fc864" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5633ce6e-5509-45e1-84b2-387f5e771701" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5633ce6e-5509-45e1-84b2-387f5e771701" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_74a10ea6-a850-4530-aaee-8a24a357f5e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_CommonStockSharesIssued_74a10ea6-a850-4530-aaee-8a24a357f5e6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_228a2b65-118c-40c9-8bc1-0630dd5f907e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_228a2b65-118c-40c9-8bc1-0630dd5f907e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_d3555dd3-4e2b-4b6e-8750-fc880aaccf07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_d3555dd3-4e2b-4b6e-8750-fc880aaccf07" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_cb3efe2e-36bf-426a-a420-3b338017ad1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_cb3efe2e-36bf-426a-a420-3b338017ad1c" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_88e0ec41-ceff-4604-b07a-3e7ab355d2c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_88e0ec41-ceff-4604-b07a-3e7ab355d2c2" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_0ae1a284-07e5-42bd-b5f6-15fbc99a5f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_0ae1a284-07e5-42bd-b5f6-15fbc99a5f5f" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCash_9606644b-d28e-46dd-a746-4981baa4efca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCash"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_DividendsCash_9606644b-d28e-46dd-a746-4981baa4efca" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2736a23c-ceda-4585-932a-0ade7d4d4017" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1c9ccea1-f7be-4781-a74d-d0c35644fd11" xlink:to="loc_us-gaap_NetIncomeLoss_2736a23c-ceda-4585-932a-0ade7d4d4017" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f46910c9-cee6-487a-ab2c-51961e20e65e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_7d41e015-9554-4726-a91e-f0c0a1d2bf78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_2ce72f99-614d-44a9-a180-765d9043de4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_c27d6925-7844-49fd-909d-484d987fc864" xlink:to="loc_us-gaap_StatementTable_2ce72f99-614d-44a9-a180-765d9043de4d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_79c543ff-4830-4236-bd2d-d090a947df89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2ce72f99-614d-44a9-a180-765d9043de4d" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_79c543ff-4830-4236-bd2d-d090a947df89" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_79c543ff-4830-4236-bd2d-d090a947df89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_79c543ff-4830-4236-bd2d-d090a947df89" xlink:to="loc_us-gaap_EquityComponentDomain_79c543ff-4830-4236-bd2d-d090a947df89_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_79c543ff-4830-4236-bd2d-d090a947df89" xlink:to="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_d0d5ed85-dcbe-49fc-8553-8a5950278152" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:to="loc_us-gaap_CommonStockMember_d0d5ed85-dcbe-49fc-8553-8a5950278152" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_7277814d-779b-41c1-b542-4a1c560f4393" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_7277814d-779b-41c1-b542-4a1c560f4393" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_5812c32f-4509-4228-8567-50ce6826f9c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:to="loc_us-gaap_RetainedEarningsMember_5812c32f-4509-4228-8567-50ce6826f9c6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_4600a43e-15b1-4e21-a74c-b8f6c5c3e8d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:to="loc_us-gaap_TreasuryStockMember_4600a43e-15b1-4e21-a74c-b8f6c5c3e8d9" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7d1ebf23-c57a-40ca-bbae-11e211aebc17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3c4ea967-4a27-4db1-90ce-51e40e2ef5dd" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_7d1ebf23-c57a-40ca-bbae-11e211aebc17" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/DisaggregationofRevenueDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#DisaggregationofRevenueDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/DisaggregationofRevenueDetails" xlink:type="extended" id="i471cc0260eff403c8f8f1258a33adeef_DisaggregationofRevenueDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_bdfea67a-2ebe-418e-9619-abb43cc72371" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_569fd67a-b48d-43d4-9159-9dad735c6738" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_bdfea67a-2ebe-418e-9619-abb43cc72371" xlink:to="loc_us-gaap_Revenues_569fd67a-b48d-43d4-9159-9dad735c6738" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_3270e316-ce12-4859-922c-c2cf7148fa9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_bdfea67a-2ebe-418e-9619-abb43cc72371" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_3270e316-ce12-4859-922c-c2cf7148fa9e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_86adecce-c0b4-485d-a2b5-d82804b10387" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3270e316-ce12-4859-922c-c2cf7148fa9e" xlink:to="loc_srt_ProductOrServiceAxis_86adecce-c0b4-485d-a2b5-d82804b10387" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_86adecce-c0b4-485d-a2b5-d82804b10387_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_86adecce-c0b4-485d-a2b5-d82804b10387" xlink:to="loc_srt_ProductsAndServicesDomain_86adecce-c0b4-485d-a2b5-d82804b10387_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_86adecce-c0b4-485d-a2b5-d82804b10387" xlink:to="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueLicensedSoftwareNetMember_90c3bc1d-c32f-4f3e-8c1f-16fd75daa086" xlink:href="cern-20220331.xsd#cern_RevenueLicensedSoftwareNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueLicensedSoftwareNetMember_90c3bc1d-c32f-4f3e-8c1f-16fd75daa086" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueTechnologyResaleNetMember_30d7fb13-2921-4f48-8b51-fce00d3b3843" xlink:href="cern-20220331.xsd#cern_RevenueTechnologyResaleNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueTechnologyResaleNetMember_30d7fb13-2921-4f48-8b51-fce00d3b3843" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueSubscriptionsNetMember_ad5033e4-b41b-47f4-87e2-a57912b66e57" xlink:href="cern-20220331.xsd#cern_RevenueSubscriptionsNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueSubscriptionsNetMember_ad5033e4-b41b-47f4-87e2-a57912b66e57" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueProfessionalServicesNetMember_b54e1067-94c2-42c6-9eaf-5d2becca2e1e" xlink:href="cern-20220331.xsd#cern_RevenueProfessionalServicesNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueProfessionalServicesNetMember_b54e1067-94c2-42c6-9eaf-5d2becca2e1e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueManagedServicesNetMember_da8431bf-0e8a-403c-adcc-66389e49e931" xlink:href="cern-20220331.xsd#cern_RevenueManagedServicesNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueManagedServicesNetMember_da8431bf-0e8a-403c-adcc-66389e49e931" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueSupportAndMaintenanceServicesNetMember_b6fe86a8-da7b-49e4-b9fe-2e42c6f23229" xlink:href="cern-20220331.xsd#cern_RevenueSupportAndMaintenanceServicesNetMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueSupportAndMaintenanceServicesNetMember_b6fe86a8-da7b-49e4-b9fe-2e42c6f23229" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueReimbursementRevenueMember_36536819-8f60-4672-9854-dfe07e2603de" xlink:href="cern-20220331.xsd#cern_RevenueReimbursementRevenueMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d34d0521-f7aa-4d5a-9f74-34122f02b132" xlink:to="loc_cern_RevenueReimbursementRevenueMember_36536819-8f60-4672-9854-dfe07e2603de" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_1fa021a4-1974-4a40-9b81-10aa8bf866bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3270e316-ce12-4859-922c-c2cf7148fa9e" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_1fa021a4-1974-4a40-9b81-10aa8bf866bc" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_1fa021a4-1974-4a40-9b81-10aa8bf866bc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1fa021a4-1974-4a40-9b81-10aa8bf866bc" xlink:to="loc_us-gaap_SegmentDomain_1fa021a4-1974-4a40-9b81-10aa8bf866bc_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_a5919c35-842b-4642-ab8c-791727f003d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1fa021a4-1974-4a40-9b81-10aa8bf866bc" xlink:to="loc_us-gaap_SegmentDomain_a5919c35-842b-4642-ab8c-791727f003d3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_DomesticSegmentMember_65b75774-5cec-41ca-8960-59311a972ba1" xlink:href="cern-20220331.xsd#cern_DomesticSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_a5919c35-842b-4642-ab8c-791727f003d3" xlink:to="loc_cern_DomesticSegmentMember_65b75774-5cec-41ca-8960-59311a972ba1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_InternationalSegmentMember_0f4e95b2-3e38-445e-991a-153de63e66c5" xlink:href="cern-20220331.xsd#cern_InternationalSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_a5919c35-842b-4642-ab8c-791727f003d3" xlink:to="loc_cern_InternationalSegmentMember_0f4e95b2-3e38-445e-991a-153de63e66c5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_a9a37c1c-04ba-474f-9640-9fc9c5d46968" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3270e316-ce12-4859-922c-c2cf7148fa9e" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_a9a37c1c-04ba-474f-9640-9fc9c5d46968" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_a9a37c1c-04ba-474f-9640-9fc9c5d46968_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_a9a37c1c-04ba-474f-9640-9fc9c5d46968" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_a9a37c1c-04ba-474f-9640-9fc9c5d46968_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_2cfcec8e-ca18-40b2-adba-ff4cbf2cafeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_a9a37c1c-04ba-474f-9640-9fc9c5d46968" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_2cfcec8e-ca18-40b2-adba-ff4cbf2cafeb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember_b0b1a4fd-edd4-4b18-a583-49c2950755f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferredOverTimeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_2cfcec8e-ca18-40b2-adba-ff4cbf2cafeb" xlink:to="loc_us-gaap_TransferredOverTimeMember_b0b1a4fd-edd4-4b18-a583-49c2950755f2" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredAtPointInTimeMember_1353f47f-c1d4-4d14-b00a-898c0ba109ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferredAtPointInTimeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_2cfcec8e-ca18-40b2-adba-ff4cbf2cafeb" xlink:to="loc_us-gaap_TransferredAtPointInTimeMember_1353f47f-c1d4-4d14-b00a-898c0ba109ad" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/PerformanceObligationDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#PerformanceObligationDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/PerformanceObligationDetails" xlink:type="extended" id="i7537f3d2590543f195b8189b85ce6dd5_PerformanceObligationDetails">
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueRecognitionLineItems_dda40d58-9ec7-4978-b418-25b92aa4ee71" xlink:href="cern-20220331.xsd#cern_RevenueRecognitionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_0988e7a4-fe8c-4828-8eaf-e622dd1aefdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cern_RevenueRecognitionLineItems_dda40d58-9ec7-4978-b418-25b92aa4ee71" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_0988e7a4-fe8c-4828-8eaf-e622dd1aefdc" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_f2236dfa-8f5b-45b9-bd5a-891124e22227" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cern_RevenueRecognitionLineItems_dda40d58-9ec7-4978-b418-25b92aa4ee71" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_f2236dfa-8f5b-45b9-bd5a-891124e22227" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_RevenueRecognitionTable_a2bfcd66-3023-4a59-a5d6-108e5002f4b9" xlink:href="cern-20220331.xsd#cern_RevenueRecognitionTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_cern_RevenueRecognitionLineItems_dda40d58-9ec7-4978-b418-25b92aa4ee71" xlink:to="loc_cern_RevenueRecognitionTable_a2bfcd66-3023-4a59-a5d6-108e5002f4b9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_TypeofRevenueAxis_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a" xlink:href="cern-20220331.xsd#cern_TypeofRevenueAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cern_RevenueRecognitionTable_a2bfcd66-3023-4a59-a5d6-108e5002f4b9" xlink:to="loc_cern_TypeofRevenueAxis_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_TypeofRevenueDomain_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a_default" xlink:href="cern-20220331.xsd#cern_TypeofRevenueDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cern_TypeofRevenueAxis_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a" xlink:to="loc_cern_TypeofRevenueDomain_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_TypeofRevenueDomain_7dfbdbe2-306b-45f9-bab3-973d91733ab9" xlink:href="cern-20220331.xsd#cern_TypeofRevenueDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cern_TypeofRevenueAxis_5e567f77-eb8f-4ae9-aa40-ecf708b81d6a" xlink:to="loc_cern_TypeofRevenueDomain_7dfbdbe2-306b-45f9-bab3-973d91733ab9" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ScheduleofValuationandQualifyingAccountsDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ScheduleofValuationandQualifyingAccountsDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ScheduleofValuationandQualifyingAccountsDetails" xlink:type="extended" id="ia694ffa9bfff40e98a1b464575af4d5a_ScheduleofValuationandQualifyingAccountsDetails">
<link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_04314ad6-aad5-4df7-909f-e8bc55e5e471" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_56c77bcd-ca8e-463e-b6c2-da3f6f3cc7ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_04314ad6-aad5-4df7-909f-e8bc55e5e471" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_56c77bcd-ca8e-463e-b6c2-da3f6f3cc7ad" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_fb788201-63df-4628-a535-bc78cb47fcfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_04314ad6-aad5-4df7-909f-e8bc55e5e471" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_fb788201-63df-4628-a535-bc78cb47fcfb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_114e4a1b-ebc8-4fc9-bd94-11faced44ff4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_04314ad6-aad5-4df7-909f-e8bc55e5e471" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_114e4a1b-ebc8-4fc9-bd94-11faced44ff4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_563c453a-dbcd-4afe-9d43-ffde66f8474e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_04314ad6-aad5-4df7-909f-e8bc55e5e471" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_563c453a-dbcd-4afe-9d43-ffde66f8474e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_7d8922e8-b83a-4bdf-9ea2-832c506282e6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_563c453a-dbcd-4afe-9d43-ffde66f8474e" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_7d8922e8-b83a-4bdf-9ea2-832c506282e6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_7d8922e8-b83a-4bdf-9ea2-832c506282e6_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_7d8922e8-b83a-4bdf-9ea2-832c506282e6" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_7d8922e8-b83a-4bdf-9ea2-832c506282e6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_6b2c42fe-aaea-4fbc-8fb4-1d1a66a9cca7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_7d8922e8-b83a-4bdf-9ea2-832c506282e6" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_6b2c42fe-aaea-4fbc-8fb4-1d1a66a9cca7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_ExpectedCreditLossesClassificationAxis_15c36f3d-31de-44d1-b260-d565f66367ae" xlink:href="cern-20220331.xsd#cern_ExpectedCreditLossesClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_563c453a-dbcd-4afe-9d43-ffde66f8474e" xlink:to="loc_cern_ExpectedCreditLossesClassificationAxis_15c36f3d-31de-44d1-b260-d565f66367ae" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_ExpectedCreditLossesClassificationDomain_15c36f3d-31de-44d1-b260-d565f66367ae_default" xlink:href="cern-20220331.xsd#cern_ExpectedCreditLossesClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cern_ExpectedCreditLossesClassificationAxis_15c36f3d-31de-44d1-b260-d565f66367ae" xlink:to="loc_cern_ExpectedCreditLossesClassificationDomain_15c36f3d-31de-44d1-b260-d565f66367ae_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_ExpectedCreditLossesClassificationDomain_db96d5c9-0681-479c-9d19-9ce3f0b2a527" xlink:href="cern-20220331.xsd#cern_ExpectedCreditLossesClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cern_ExpectedCreditLossesClassificationAxis_15c36f3d-31de-44d1-b260-d565f66367ae" xlink:to="loc_cern_ExpectedCreditLossesClassificationDomain_db96d5c9-0681-479c-9d19-9ce3f0b2a527" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_CurrentExpectedCreditLossesMember_ace1be83-5a01-4607-b116-adc8ae67b46b" xlink:href="cern-20220331.xsd#cern_CurrentExpectedCreditLossesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cern_ExpectedCreditLossesClassificationDomain_db96d5c9-0681-479c-9d19-9ce3f0b2a527" xlink:to="loc_cern_CurrentExpectedCreditLossesMember_ace1be83-5a01-4607-b116-adc8ae67b46b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_NonCurrentExpectedCreditLossesMember_61e76ecb-4cf2-4b3d-b2ff-c7f20b983522" xlink:href="cern-20220331.xsd#cern_NonCurrentExpectedCreditLossesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cern_ExpectedCreditLossesClassificationDomain_db96d5c9-0681-479c-9d19-9ce3f0b2a527" xlink:to="loc_cern_NonCurrentExpectedCreditLossesMember_61e76ecb-4cf2-4b3d-b2ff-c7f20b983522" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/InvestmentsDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#InvestmentsDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/InvestmentsDetails" xlink:type="extended" id="ia34211c9b1c149b09f53d066ffdcf58a_InvestmentsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_a550a92a-8af8-42d5-939f-3d970891514d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_a550a92a-8af8-42d5-939f-3d970891514d" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_d6842107-0c7c-49d2-91a1-2ffa6b3ddf81" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_d6842107-0c7c-49d2-91a1-2ffa6b3ddf81" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_14465a33-688c-44e9-8e6b-d0e903de9f8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_14465a33-688c-44e9-8e6b-d0e903de9f8c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_91ad2079-7fc3-49ff-ba42-9ca7d18ea4aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_91ad2079-7fc3-49ff-ba42-9ca7d18ea4aa" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_9f72aedf-164d-4b75-918d-893dbe7c20e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_dbcc3a05-a230-4faf-8ca9-97d2c03d5fc2" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_9f72aedf-164d-4b75-918d-893dbe7c20e8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_28783b0a-8df6-4138-bfdb-0931456c5508" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_9f72aedf-164d-4b75-918d-893dbe7c20e8" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_28783b0a-8df6-4138-bfdb-0931456c5508" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_28783b0a-8df6-4138-bfdb-0931456c5508_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_28783b0a-8df6-4138-bfdb-0931456c5508" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_28783b0a-8df6-4138-bfdb-0931456c5508_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_206bd8ea-d331-4423-9d6f-496757773350" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_28783b0a-8df6-4138-bfdb-0931456c5508" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_206bd8ea-d331-4423-9d6f-496757773350" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_c9a4e4c5-918b-4599-a530-be624246238c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_206bd8ea-d331-4423-9d6f-496757773350" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_c9a4e4c5-918b-4599-a530-be624246238c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_1f7b3130-4bc6-4970-991a-849dfc6dbc94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_206bd8ea-d331-4423-9d6f-496757773350" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_1f7b3130-4bc6-4970-991a-849dfc6dbc94" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_LongTermInvestmentsMember_46832f1f-79ff-41e7-a29a-7534e4d386e3" xlink:href="cern-20220331.xsd#cern_LongTermInvestmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_206bd8ea-d331-4423-9d6f-496757773350" xlink:to="loc_cern_LongTermInvestmentsMember_46832f1f-79ff-41e7-a29a-7534e4d386e3" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_ef8a111b-2adb-47da-88f1-f226380babeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_9f72aedf-164d-4b75-918d-893dbe7c20e8" xlink:to="loc_us-gaap_FinancialInstrumentAxis_ef8a111b-2adb-47da-88f1-f226380babeb" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef8a111b-2adb-47da-88f1-f226380babeb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_ef8a111b-2adb-47da-88f1-f226380babeb" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef8a111b-2adb-47da-88f1-f226380babeb_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_ef8a111b-2adb-47da-88f1-f226380babeb" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_6b3b133e-42ed-45fb-ab1f-e3054557502a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:to="loc_us-gaap_MoneyMarketFundsMember_6b3b133e-42ed-45fb-ab1f-e3054557502a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_c04ae799-a83a-42f2-9a27-079e34d2cacf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankTimeDepositsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:to="loc_us-gaap_BankTimeDepositsMember_c04ae799-a83a-42f2-9a27-079e34d2cacf" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_26bb5ee0-5453-485d-b361-7750a9f97f64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:to="loc_us-gaap_CommercialPaperMember_26bb5ee0-5453-485d-b361-7750a9f97f64" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_GovernmentAndCorporateBondsMember_9bdb76e2-e4c5-42be-83e2-1327c7d64981" xlink:href="cern-20220331.xsd#cern_GovernmentAndCorporateBondsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57a01ab7-6d9e-42aa-9b20-53ffcf85ee6d" xlink:to="loc_cern_GovernmentAndCorporateBondsMember_9bdb76e2-e4c5-42be-83e2-1327c7d64981" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ScheduleofIndebtednessOutstandingDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ScheduleofIndebtednessOutstandingDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ScheduleofIndebtednessOutstandingDetails" xlink:type="extended" id="id9d514243f47444b9b52f9b12d953d1c_ScheduleofIndebtednessOutstandingDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_21fe8b6a-ad26-4e3b-bc97-5e04be83e0b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_LongTermDebt_21fe8b6a-ad26-4e3b-bc97-5e04be83e0b0" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_b34a51c5-4b03-4964-b1f8-4f0631699497" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNoncurrentNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_b34a51c5-4b03-4964-b1f8-4f0631699497" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_LongTermDebtNetOfDebtIssuancesCosts_8d376592-932e-450b-a21a-aa0a28fe7b34" xlink:href="cern-20220331.xsd#cern_LongTermDebtNetOfDebtIssuancesCosts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_cern_LongTermDebtNetOfDebtIssuancesCosts_8d376592-932e-450b-a21a-aa0a28fe7b34" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_62645912-1108-4ba8-a28e-8f3414241829" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_LongTermDebtCurrent_62645912-1108-4ba8-a28e-8f3414241829" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_ac0d5e03-3952-4166-8dc1-c5fb0a7d1232" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_ac0d5e03-3952-4166-8dc1-c5fb0a7d1232" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_d469b7f5-2e53-40a4-a344-e9f8ad73647c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentMaturityDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_d469b7f5-2e53-40a4-a344-e9f8ad73647c" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_a2013ddd-cd71-4540-8507-3a8baf6dd968" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_cf5fdbe2-2b44-4ed9-ae96-402e42e96bae" xlink:to="loc_us-gaap_DebtInstrumentTable_a2013ddd-cd71-4540-8507-3a8baf6dd968" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_85e5dfab-eff6-43ba-83cd-5c2a46599e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_a2013ddd-cd71-4540-8507-3a8baf6dd968" xlink:to="loc_us-gaap_DebtInstrumentAxis_85e5dfab-eff6-43ba-83cd-5c2a46599e7e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_85e5dfab-eff6-43ba-83cd-5c2a46599e7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_85e5dfab-eff6-43ba-83cd-5c2a46599e7e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_85e5dfab-eff6-43ba-83cd-5c2a46599e7e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_85e5dfab-eff6-43ba-83cd-5c2a46599e7e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_46e6e190-f1b7-4834-be8b-ce380400d397" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_us-gaap_LineOfCreditMember_46e6e190-f1b7-4834-be8b-ce380400d397" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2021ADueMarch242026Member_e3eb2d3a-dcd7-4760-9178-1f32ea361c69" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2021ADueMarch242026Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_SeniorNotesSeries2021ADueMarch242026Member_e3eb2d3a-dcd7-4760-9178-1f32ea361c69" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2021BDueMarch242031Member_5d87c196-44cf-412a-aa11-a379cf869ac9" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2021BDueMarch242031Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_SeniorNotesSeries2021BDueMarch242031Member_5d87c196-44cf-412a-aa11-a379cf869ac9" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2020ADueMarch112030Member_13d59136-de59-4fc4-9cd5-cd02b2bc5564" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2020ADueMarch112030Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_SeniorNotesSeries2020ADueMarch112030Member_13d59136-de59-4fc4-9cd5-cd02b2bc5564" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2015ADueFebruary152022Member_b1e0c2d3-f224-4c6a-8fca-2bcd378e18c0" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2015ADueFebruary152022Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_SeniorNotesSeries2015ADueFebruary152022Member_b1e0c2d3-f224-4c6a-8fca-2bcd378e18c0" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2015BDueFebruary142025Member_53ad1696-fd3a-482e-964e-51cfca35b035" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2015BDueFebruary142025Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_SeniorNotesSeries2015BDueFebruary142025Member_53ad1696-fd3a-482e-964e-51cfca35b035" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_OtherMember_ab7fe99e-95a9-4a10-aed3-e3d3cf0656d1" xlink:href="cern-20220331.xsd#cern_OtherMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f819475f-5854-468e-bb7b-42a8f2683303" xlink:to="loc_cern_OtherMember_ab7fe99e-95a9-4a10-aed3-e3d3cf0656d1" xlink:type="arc" order="6"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/IndebtednessNarrativeDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#IndebtednessNarrativeDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/IndebtednessNarrativeDetails" xlink:type="extended" id="ife9c7aba0a6b46ab9f461f8cd7b91d3e_IndebtednessNarrativeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_e28f8abb-8bb0-4214-ad7d-7d9bf2067335" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_e28f8abb-8bb0-4214-ad7d-7d9bf2067335" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralDiscussionOfDerivativeInstrumentsAndHedgingActivities_29156964-4b21-485f-9868-0304d66016d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralDiscussionOfDerivativeInstrumentsAndHedgingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:to="loc_us-gaap_GeneralDiscussionOfDerivativeInstrumentsAndHedgingActivities_29156964-4b21-485f-9868-0304d66016d1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_e984f9d6-0fda-4787-87a6-9b14197ff5f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_e984f9d6-0fda-4787-87a6-9b14197ff5f5" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_f69aaf7e-1c29-4bf0-9c10-d2ed7367bb3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentMaturityDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_f69aaf7e-1c29-4bf0-9c10-d2ed7367bb3c" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_f845e520-5c2c-4d08-82c4-a1f22b970543" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_12ee698d-62da-4f40-bc69-99bb110efe67" xlink:to="loc_us-gaap_DebtInstrumentTable_f845e520-5c2c-4d08-82c4-a1f22b970543" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_f845e520-5c2c-4d08-82c4-a1f22b970543" xlink:to="loc_us-gaap_DebtInstrumentAxis_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_5e599692-0db0-406e-af8b-7dee749458fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_2e56a3fe-8f8d-47c6-bc72-e4af8f44ab72" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_5e599692-0db0-406e-af8b-7dee749458fb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2020ADueMarch112030Member_9fdddb59-8e9c-4ac8-9243-a5e7f00e25dd" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2020ADueMarch112030Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_5e599692-0db0-406e-af8b-7dee749458fb" xlink:to="loc_cern_SeniorNotesSeries2020ADueMarch112030Member_9fdddb59-8e9c-4ac8-9243-a5e7f00e25dd" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2021ADueMarch242026Member_8f593b00-fd2e-41f6-b77f-40612224a376" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2021ADueMarch242026Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_5e599692-0db0-406e-af8b-7dee749458fb" xlink:to="loc_cern_SeniorNotesSeries2021ADueMarch242026Member_8f593b00-fd2e-41f6-b77f-40612224a376" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_SeniorNotesSeries2021BDueMarch242031Member_ecd69901-9ff8-464b-bed4-4e201ec06d34" xlink:href="cern-20220331.xsd#cern_SeniorNotesSeries2021BDueMarch242031Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_5e599692-0db0-406e-af8b-7dee749458fb" xlink:to="loc_cern_SeniorNotesSeries2021BDueMarch242031Member_ecd69901-9ff8-464b-bed4-4e201ec06d34" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/FairValueMeasurementsFairValueAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#FairValueMeasurementsFairValueAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/FairValueMeasurementsFairValueAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended" id="i3d7f1f94afc54bfbbc9c186135731940_FairValueMeasurementsFairValueAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_cd82ab89-9e27-47cf-bf21-531c4f48133e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_97227fb0-fba0-422b-9fa7-5784d30fe15f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_cd82ab89-9e27-47cf-bf21-531c4f48133e" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_97227fb0-fba0-422b-9fa7-5784d30fe15f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_11f2773b-a7ac-4e66-b1c4-c85189ed3250" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_cd82ab89-9e27-47cf-bf21-531c4f48133e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_11f2773b-a7ac-4e66-b1c4-c85189ed3250" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_cd82ab89-9e27-47cf-bf21-531c4f48133e" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_d630fa05-fe81-4b72-b47c-f98f2247d839" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_d630fa05-fe81-4b72-b47c-f98f2247d839" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_d630fa05-fe81-4b72-b47c-f98f2247d839_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_d630fa05-fe81-4b72-b47c-f98f2247d839" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_d630fa05-fe81-4b72-b47c-f98f2247d839_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_f5e424e1-7d31-416a-904a-d0eb5fdf5ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_d630fa05-fe81-4b72-b47c-f98f2247d839" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_f5e424e1-7d31-416a-904a-d0eb5fdf5ce6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_fa099bfc-171f-4228-b5d4-a3c96b0744c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f5e424e1-7d31-416a-904a-d0eb5fdf5ce6" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_fa099bfc-171f-4228-b5d4-a3c96b0744c3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_LongTermInvestmentsMember_1a345529-d631-4ada-bd93-a0a642822e5e" xlink:href="cern-20220331.xsd#cern_LongTermInvestmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f5e424e1-7d31-416a-904a-d0eb5fdf5ce6" xlink:to="loc_cern_LongTermInvestmentsMember_1a345529-d631-4ada-bd93-a0a642822e5e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_08764268-61aa-40a7-b799-e27b67fef1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_71ccd3b4-dca7-4531-a4bb-4e7fed7c955a" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_08764268-61aa-40a7-b799-e27b67fef1b5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_8d5b5837-2653-42b4-9719-d9c2d652f8f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_08764268-61aa-40a7-b799-e27b67fef1b5" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_8d5b5837-2653-42b4-9719-d9c2d652f8f8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_742aad84-6c00-426b-bca6-fd0016abf8a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_08764268-61aa-40a7-b799-e27b67fef1b5" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_742aad84-6c00-426b-bca6-fd0016abf8a5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_b61068af-74cb-4bd7-9db0-d7bd5a606008" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_08764268-61aa-40a7-b799-e27b67fef1b5" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_b61068af-74cb-4bd7-9db0-d7bd5a606008" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_140beebc-d7a3-4207-8666-a882ab27c938" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:to="loc_us-gaap_InvestmentTypeAxis_140beebc-d7a3-4207-8666-a882ab27c938" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_140beebc-d7a3-4207-8666-a882ab27c938_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_InvestmentTypeAxis_140beebc-d7a3-4207-8666-a882ab27c938" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_140beebc-d7a3-4207-8666-a882ab27c938_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_InvestmentTypeAxis_140beebc-d7a3-4207-8666-a882ab27c938" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_6ca7aff1-e03b-4933-9e5e-bc334fde5bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:to="loc_us-gaap_MoneyMarketFundsMember_6ca7aff1-e03b-4933-9e5e-bc334fde5bf8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_275d6bad-d96b-4cc9-b5c3-e48229274d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankTimeDepositsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:to="loc_us-gaap_BankTimeDepositsMember_275d6bad-d96b-4cc9-b5c3-e48229274d5f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_4a22e9e2-55ac-4a0c-bd11-42727f154f1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:to="loc_us-gaap_CommercialPaperMember_4a22e9e2-55ac-4a0c-bd11-42727f154f1c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_GovernmentAndCorporateBondsMember_54f87221-2aff-4f14-80cc-9d781d00f050" xlink:href="cern-20220331.xsd#cern_GovernmentAndCorporateBondsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_d817289f-60eb-4798-843a-9d7ea67aee7e" xlink:to="loc_cern_GovernmentAndCorporateBondsMember_54f87221-2aff-4f14-80cc-9d781d00f050" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_423da9f4-d66d-41cd-a49c-f39619678c31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_80281044-7736-4952-90d7-635ef87d684b" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_423da9f4-d66d-41cd-a49c-f39619678c31" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_423da9f4-d66d-41cd-a49c-f39619678c31_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_423da9f4-d66d-41cd-a49c-f39619678c31" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_423da9f4-d66d-41cd-a49c-f39619678c31_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_a24842a9-b30c-4e31-870b-825a84033b49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_423da9f4-d66d-41cd-a49c-f39619678c31" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_a24842a9-b30c-4e31-870b-825a84033b49" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_7a5d4f19-a3c7-4794-a64e-8636ccdbc552" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_a24842a9-b30c-4e31-870b-825a84033b49" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_7a5d4f19-a3c7-4794-a64e-8636ccdbc552" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ShareBasedCompensationScheduleOfNonVestedSharesActivityDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ShareBasedCompensationScheduleOfNonVestedSharesActivityDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ShareBasedCompensationScheduleOfNonVestedSharesActivityDetails" xlink:type="extended" id="ibcdaf44a8b1f4e9da7ebacd873d0f662_ShareBasedCompensationScheduleOfNonVestedSharesActivityDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f01ebaf4-13fa-4a99-8d2f-e54286b6faf4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f01ebaf4-13fa-4a99-8d2f-e54286b6faf4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_1ed33cc7-86ff-4728-b158-df567ee6177b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_1ed33cc7-86ff-4728-b158-df567ee6177b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b9c3d868-eb50-4f3f-a72e-514d24a3e24b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b9c3d868-eb50-4f3f-a72e-514d24a3e24b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_99903ee5-6db8-4ae5-96b8-5f8141f6f5a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_99903ee5-6db8-4ae5-96b8-5f8141f6f5a7" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_81fe59f3-db5c-4afe-8959-dce0774636cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_81fe59f3-db5c-4afe-8959-dce0774636cf" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_6d03406f-e4cb-4de0-8109-0d08d7d85a10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_6d03406f-e4cb-4de0-8109-0d08d7d85a10" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_8e5e0e47-c18c-4aba-85ca-f30c19603119" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_8e5e0e47-c18c-4aba-85ca-f30c19603119" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_9810ebb6-e90d-412f-b649-557fb22255d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_9810ebb6-e90d-412f-b649-557fb22255d5" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_ce6cd6d9-c2ee-4156-beff-226b6bb37a8d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_7a9f9315-4b26-43ac-959f-d6b27ec988e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e697d4da-4c95-43ba-9768-12fe2df59512" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c897d846-107d-4fd9-acbc-f6372eed15e0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e697d4da-4c95-43ba-9768-12fe2df59512" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_68ab5c45-a034-4f26-bbcc-0f94b97efcc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e697d4da-4c95-43ba-9768-12fe2df59512" xlink:to="loc_us-gaap_AwardTypeAxis_68ab5c45-a034-4f26-bbcc-0f94b97efcc8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_68ab5c45-a034-4f26-bbcc-0f94b97efcc8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_68ab5c45-a034-4f26-bbcc-0f94b97efcc8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_68ab5c45-a034-4f26-bbcc-0f94b97efcc8_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_72eb34c9-348c-4cdb-9405-2fd83d84f56f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_68ab5c45-a034-4f26-bbcc-0f94b97efcc8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_72eb34c9-348c-4cdb-9405-2fd83d84f56f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_d930b6c2-c5f9-4335-a99e-ccef0634f9c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_72eb34c9-348c-4cdb-9405-2fd83d84f56f" xlink:to="loc_us-gaap_RestrictedStockMember_d930b6c2-c5f9-4335-a99e-ccef0634f9c5" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ShareBasedCompensationCompensationExpenseRecognizedInTheCondensedConsolidatedStatementsOfOperationsDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ShareBasedCompensationCompensationExpenseRecognizedInTheCondensedConsolidatedStatementsOfOperationsDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ShareBasedCompensationCompensationExpenseRecognizedInTheCondensedConsolidatedStatementsOfOperationsDetails" xlink:type="extended" id="i043da38fdf0248d8b33667d8b2373d80_ShareBasedCompensationCompensationExpenseRecognizedInTheCondensedConsolidatedStatementsOfOperationsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4483f3-edec-4ef9-babd-e5ba8da81983" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_4169394f-595c-40ae-a342-53d4dc0046b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4483f3-edec-4ef9-babd-e5ba8da81983" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_4169394f-595c-40ae-a342-53d4dc0046b7" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_7050535d-f402-4200-9e5f-65a540c8ec68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4483f3-edec-4ef9-babd-e5ba8da81983" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_7050535d-f402-4200-9e5f-65a540c8ec68" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8cf12203-5980-4c23-96cb-5d98bc4392b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4483f3-edec-4ef9-babd-e5ba8da81983" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8cf12203-5980-4c23-96cb-5d98bc4392b4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8cf12203-5980-4c23-96cb-5d98bc4392b4" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_bb3f1b03-e8f4-4dfe-9252-74f350e81603" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ae28c2b3-9f27-48ec-9880-e13fc6b73eaf" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_bb3f1b03-e8f4-4dfe-9252-74f350e81603" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_StockOptionAndNonVestedShareCompensationExpenseMember_feb75e15-008d-47d4-83ee-267db3ac9bb9" xlink:href="cern-20220331.xsd#cern_StockOptionAndNonVestedShareCompensationExpenseMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bb3f1b03-e8f4-4dfe-9252-74f350e81603" xlink:to="loc_cern_StockOptionAndNonVestedShareCompensationExpenseMember_feb75e15-008d-47d4-83ee-267db3ac9bb9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_AssociateStockPurchasePlanExpenseMember_84899f86-1656-44c1-8563-c2ce1fee577f" xlink:href="cern-20220331.xsd#cern_AssociateStockPurchasePlanExpenseMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bb3f1b03-e8f4-4dfe-9252-74f350e81603" xlink:to="loc_cern_AssociateStockPurchasePlanExpenseMember_84899f86-1656-44c1-8563-c2ce1fee577f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_AmountsCapitalizedInSoftwareDevelopmentCostsMember_55e8aab1-9f41-435f-b445-b4b691a0153f" xlink:href="cern-20220331.xsd#cern_AmountsCapitalizedInSoftwareDevelopmentCostsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bb3f1b03-e8f4-4dfe-9252-74f350e81603" xlink:to="loc_cern_AmountsCapitalizedInSoftwareDevelopmentCostsMember_55e8aab1-9f41-435f-b445-b4b691a0153f" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ScheduleofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ScheduleofAccumulatedOtherComprehensiveIncomeLossDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ScheduleofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended" id="id30ea0d8ced242cd82490a7ae1571cd1_ScheduleofAccumulatedOtherComprehensiveIncomeLossDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fd137465-812d-48d9-a073-8f387a7997ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ce5e50ed-041f-4a44-ab78-cf7a859628f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fd137465-812d-48d9-a073-8f387a7997ba" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ce5e50ed-041f-4a44-ab78-cf7a859628f4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_67e23c05-0998-490f-b2a2-64943e231bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fd137465-812d-48d9-a073-8f387a7997ba" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_67e23c05-0998-490f-b2a2-64943e231bc0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_9e2b2de1-7be5-4c54-9873-0279459f9575" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fd137465-812d-48d9-a073-8f387a7997ba" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_9e2b2de1-7be5-4c54-9873-0279459f9575" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0e83ba30-d734-4b1a-ad3b-d2326e5b4eec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fd137465-812d-48d9-a073-8f387a7997ba" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0e83ba30-d734-4b1a-ad3b-d2326e5b4eec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_af055235-4781-4d08-bddf-80641af43956" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0e83ba30-d734-4b1a-ad3b-d2326e5b4eec" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_af055235-4781-4d08-bddf-80641af43956" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_af055235-4781-4d08-bddf-80641af43956_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_af055235-4781-4d08-bddf-80641af43956" xlink:to="loc_us-gaap_EquityComponentDomain_af055235-4781-4d08-bddf-80641af43956_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a1c8d3a9-af4a-4f89-8d4b-bb0d242aeb93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_af055235-4781-4d08-bddf-80641af43956" xlink:to="loc_us-gaap_EquityComponentDomain_a1c8d3a9-af4a-4f89-8d4b-bb0d242aeb93" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_60651550-f82d-4c54-affe-1cc7b746301c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a1c8d3a9-af4a-4f89-8d4b-bb0d242aeb93" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_60651550-f82d-4c54-affe-1cc7b746301c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_5fbef99b-0fe2-484f-8f8d-1a864d890fd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a1c8d3a9-af4a-4f89-8d4b-bb0d242aeb93" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_5fbef99b-0fe2-484f-8f8d-1a864d890fd7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_a5f22c37-8c91-4b4a-aae2-fa1dc45ebb16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a1c8d3a9-af4a-4f89-8d4b-bb0d242aeb93" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_a5f22c37-8c91-4b4a-aae2-fa1dc45ebb16" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended" id="i981a0993f9044a58a020a45c8a3f9f89_ReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_94555f00-582c-4455-a657-1b09c7358cf5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_1d7592ab-4d45-495e-b9c7-9fbfc4f3713a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_94555f00-582c-4455-a657-1b09c7358cf5" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_1d7592ab-4d45-495e-b9c7-9fbfc4f3713a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_924c8d4e-5b93-44ee-92ac-a2f93d37a418" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_94555f00-582c-4455-a657-1b09c7358cf5" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_924c8d4e-5b93-44ee-92ac-a2f93d37a418" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6a92d65f-09f4-4e68-b08d-af2b621cfd03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_94555f00-582c-4455-a657-1b09c7358cf5" xlink:to="loc_us-gaap_NetIncomeLoss_6a92d65f-09f4-4e68-b08d-af2b621cfd03" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_18759093-c08e-447b-a1eb-9d91acb391ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_94555f00-582c-4455-a657-1b09c7358cf5" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_18759093-c08e-447b-a1eb-9d91acb391ba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_18759093-c08e-447b-a1eb-9d91acb391ba" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_c141c4f0-70b7-4e5f-9174-4bd7cc4abe5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_8d1d70f7-67bc-460f-9f1f-18f3cf36fd48" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_c141c4f0-70b7-4e5f-9174-4bd7cc4abe5f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_1a290d45-f1a7-439f-a49f-9453d334a5ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_c141c4f0-70b7-4e5f-9174-4bd7cc4abe5f" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_1a290d45-f1a7-439f-a49f-9453d334a5ed" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_3b91da55-f4d6-46eb-a587-355ba08f9de5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_18759093-c08e-447b-a1eb-9d91acb391ba" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_3b91da55-f4d6-46eb-a587-355ba08f9de5" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3b91da55-f4d6-46eb-a587-355ba08f9de5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3b91da55-f4d6-46eb-a587-355ba08f9de5" xlink:to="loc_us-gaap_EquityComponentDomain_3b91da55-f4d6-46eb-a587-355ba08f9de5_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_8c91e588-54bd-4118-9066-aed91e592a8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3b91da55-f4d6-46eb-a587-355ba08f9de5" xlink:to="loc_us-gaap_EquityComponentDomain_8c91e588-54bd-4118-9066-aed91e592a8e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_42216704-248e-4d23-9f95-c8ea9a4a0966" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8c91e588-54bd-4118-9066-aed91e592a8e" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_42216704-248e-4d23-9f95-c8ea9a4a0966" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_17053c70-92a9-4617-9473-1c3f5424ffc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8c91e588-54bd-4118-9066-aed91e592a8e" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_17053c70-92a9-4617-9473-1c3f5424ffc5" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ShareBasedCompensationNarrativeDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended" id="i7c35d7d9a0ae462485eacd415d6729ae_ShareBasedCompensationNarrativeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_43839d8e-44bb-486f-873e-68c5db60f40d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_43839d8e-44bb-486f-873e-68c5db60f40d" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_cf458c13-8747-48dd-82ae-2bbdc1b8d619" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_cf458c13-8747-48dd-82ae-2bbdc1b8d619" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_d76c0945-e0e1-4417-ae1a-79a934bd2938" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_d76c0945-e0e1-4417-ae1a-79a934bd2938" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableDateDeclaredDayMonthAndYear_49556892-6f85-4b4f-9f1e-71238d92290b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableDateDeclaredDayMonthAndYear"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_DividendsPayableDateDeclaredDayMonthAndYear_49556892-6f85-4b4f-9f1e-71238d92290b" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableAmountPerShare_29d61fbf-28d4-44ba-9820-59ca75b761a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableAmountPerShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_DividendsPayableAmountPerShare_29d61fbf-28d4-44ba-9820-59ca75b761a4" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendPayableDateToBePaidDayMonthAndYear_e29a0947-385f-4707-b778-a8982557b4d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendPayableDateToBePaidDayMonthAndYear"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_DividendPayableDateToBePaidDayMonthAndYear_e29a0947-385f-4707-b778-a8982557b4d8" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableDateOfRecordDayMonthAndYear_74d486ef-730f-43be-b8d7-4ca68402c0b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableDateOfRecordDayMonthAndYear"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_DividendsPayableDateOfRecordDayMonthAndYear_74d486ef-730f-43be-b8d7-4ca68402c0b4" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_8c1ac9e1-1016-4f70-ae0f-7775f8dc155f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_8c1ac9e1-1016-4f70-ae0f-7775f8dc155f" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_39c8dbd2-7c0a-46ff-995f-f2c21f89f6af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_39c8dbd2-7c0a-46ff-995f-f2c21f89f6af" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_2aa79d89-5426-4526-b29b-36b98b691780" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a0310201-5bc7-4295-ad42-377a14657824" xlink:to="loc_us-gaap_StatementTable_2aa79d89-5426-4526-b29b-36b98b691780" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_ce612149-b782-4fa6-9811-f8b6dec2a7d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2aa79d89-5426-4526-b29b-36b98b691780" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_ce612149-b782-4fa6-9811-f8b6dec2a7d3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_ce612149-b782-4fa6-9811-f8b6dec2a7d3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ce612149-b782-4fa6-9811-f8b6dec2a7d3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_ce612149-b782-4fa6-9811-f8b6dec2a7d3_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_db21ea55-1dca-4941-834f-2d05633be8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ce612149-b782-4fa6-9811-f8b6dec2a7d3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_db21ea55-1dca-4941-834f-2d05633be8e2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_453832ec-09b0-480a-b5ef-5b860dd18d4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2aa79d89-5426-4526-b29b-36b98b691780" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_453832ec-09b0-480a-b5ef-5b860dd18d4f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_453832ec-09b0-480a-b5ef-5b860dd18d4f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_453832ec-09b0-480a-b5ef-5b860dd18d4f" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_453832ec-09b0-480a-b5ef-5b860dd18d4f_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_f24d9d2d-43db-4e60-9a02-5ef858c5949d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_453832ec-09b0-480a-b5ef-5b860dd18d4f" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_f24d9d2d-43db-4e60-9a02-5ef858c5949d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_96c5e012-e1a1-4937-9e9e-f3552f9d6755" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2aa79d89-5426-4526-b29b-36b98b691780" xlink:to="loc_us-gaap_AwardTypeAxis_96c5e012-e1a1-4937-9e9e-f3552f9d6755" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_96c5e012-e1a1-4937-9e9e-f3552f9d6755_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_96c5e012-e1a1-4937-9e9e-f3552f9d6755" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_96c5e012-e1a1-4937-9e9e-f3552f9d6755_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_eb8ee3b9-5849-438b-838f-2e4ac693f6dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_96c5e012-e1a1-4937-9e9e-f3552f9d6755" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_eb8ee3b9-5849-438b-838f-2e4ac693f6dd" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_e765ba4b-2a0d-4290-8893-30576b9e9853" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_eb8ee3b9-5849-438b-838f-2e4ac693f6dd" xlink:to="loc_us-gaap_EmployeeStockOptionMember_e765ba4b-2a0d-4290-8893-30576b9e9853" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_37cce5f4-374c-4ad5-abfe-b3ea8d19af15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_eb8ee3b9-5849-438b-838f-2e4ac693f6dd" xlink:to="loc_us-gaap_RestrictedStockMember_37cce5f4-374c-4ad5-abfe-b3ea8d19af15" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/ContingenciesContingenciesDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#ContingenciesContingenciesDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/ContingenciesContingenciesDetails" xlink:type="extended" id="i5118e3bb326a45689ff3aa4ed71d39fe_ContingenciesContingenciesDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_910e323c-adcf-46dd-9e75-002df7651101" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyManagementsAssessmentAndProcess_62d63b0f-02b8-452a-9ec4-29a0519aace0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyManagementsAssessmentAndProcess"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_910e323c-adcf-46dd-9e75-002df7651101" xlink:to="loc_us-gaap_LossContingencyManagementsAssessmentAndProcess_62d63b0f-02b8-452a-9ec4-29a0519aace0" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_c042f5c3-4a74-44df-8732-d0f17885ac19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_910e323c-adcf-46dd-9e75-002df7651101" xlink:to="loc_us-gaap_LossContingenciesTable_c042f5c3-4a74-44df-8732-d0f17885ac19" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6e607186-dd05-49c3-a5e0-1303ebd73505" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_c042f5c3-4a74-44df-8732-d0f17885ac19" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6e607186-dd05-49c3-a5e0-1303ebd73505" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_6e607186-dd05-49c3-a5e0-1303ebd73505_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6e607186-dd05-49c3-a5e0-1303ebd73505" xlink:to="loc_us-gaap_LossContingencyNatureDomain_6e607186-dd05-49c3-a5e0-1303ebd73505_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_5f6e4872-7fde-4ed1-8045-e041b6d67797" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6e607186-dd05-49c3-a5e0-1303ebd73505" xlink:to="loc_us-gaap_LossContingencyNatureDomain_5f6e4872-7fde-4ed1-8045-e041b6d67797" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_StewardHealthCareSystemLLCMember_23fff8cf-1fb4-4ca8-9fb0-4a7bc872692f" xlink:href="cern-20220331.xsd#cern_StewardHealthCareSystemLLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_5f6e4872-7fde-4ed1-8045-e041b6d67797" xlink:to="loc_cern_StewardHealthCareSystemLLCMember_23fff8cf-1fb4-4ca8-9fb0-4a7bc872692f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_AstriaHealthMember_b492aa03-7284-45bf-aad7-491b76ad34ac" xlink:href="cern-20220331.xsd#cern_AstriaHealthMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_5f6e4872-7fde-4ed1-8045-e041b6d67797" xlink:to="loc_cern_AstriaHealthMember_b492aa03-7284-45bf-aad7-491b76ad34ac" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.cerner.com/role/SegmentReportingSummaryOfTheOperatingInformationDetails" xlink:type="simple" xlink:href="cern-20220331.xsd#SegmentReportingSummaryOfTheOperatingInformationDetails"/>
<link:definitionLink xlink:role="http://www.cerner.com/role/SegmentReportingSummaryOfTheOperatingInformationDetails" xlink:type="extended" id="ic5fb8a0fac21410888a4864afcb3a7f9_SegmentReportingSummaryOfTheOperatingInformationDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_02c95282-03f7-49a9-b2ef-a7fe3740a2ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_Revenues_02c95282-03f7-49a9-b2ef-a7fe3740a2ce" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_b9f69f86-2952-4f61-9e5d-74e90a00b8d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_b9f69f86-2952-4f61-9e5d-74e90a00b8d8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_4c344535-4ce1-4814-ad0f-f2a810059cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_OperatingExpenses_4c344535-4ce1-4814-ad0f-f2a810059cfb" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_67000905-38f4-4863-9126-4f161de03513" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_CostsAndExpenses_67000905-38f4-4863-9126-4f161de03513" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_16f871f2-99f2-4f9d-946e-69e5112c604c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_OperatingIncomeLoss_16f871f2-99f2-4f9d-946e-69e5112c604c" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1414f40c-8441-4afc-b242-1e0c64023d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_50d9df59-0e02-4d6a-addc-c6d87e5e001c" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1414f40c-8441-4afc-b242-1e0c64023d3e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1414f40c-8441-4afc-b242-1e0c64023d3e" xlink:to="loc_srt_StatementGeographicalAxis_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34" xlink:to="loc_srt_SegmentGeographicalDomain_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_5dbfa168-b807-448e-b41f-0e62390938f0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_4ddfcce6-1b6c-4b4a-bccb-3aa4a84efb34" xlink:to="loc_srt_SegmentGeographicalDomain_5dbfa168-b807-448e-b41f-0e62390938f0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_DomesticSegmentMember_af9215ec-cae7-4d51-9a9a-be59a09d345c" xlink:href="cern-20220331.xsd#cern_DomesticSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_5dbfa168-b807-448e-b41f-0e62390938f0" xlink:to="loc_cern_DomesticSegmentMember_af9215ec-cae7-4d51-9a9a-be59a09d345c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_InternationalSegmentMember_a053221f-b857-4aeb-b5cd-d9fc609a2ec2" xlink:href="cern-20220331.xsd#cern_InternationalSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_5dbfa168-b807-448e-b41f-0e62390938f0" xlink:to="loc_cern_InternationalSegmentMember_a053221f-b857-4aeb-b5cd-d9fc609a2ec2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_cern_OtherSegmentMember_0bf6142a-abec-4f6f-970f-550f769197f2" xlink:href="cern-20220331.xsd#cern_OtherSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_5dbfa168-b807-448e-b41f-0e62390938f0" xlink:to="loc_cern_OtherSegmentMember_0bf6142a-abec-4f6f-970f-550f769197f2" xlink:type="arc" order="2"/>
</link:definitionLink>
</link:linkbase>

1 Previous Filing that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 1/19/22  Cerner Corp.                      SC 14D9               10:1.3M Cerner Corp.                      Donnelley … Solutions/FA
↑Top
Filing Submission 0000804753-22-000024   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Fri., May 17, 12:49:31.1pm ET