SEC Info - Healthcare Ventures II LP, et al. - ‘SC 13G/A’ on 2/11/02 re: Celldex Therapeutics, Inc.

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Healthcare Ventures II LP, et al. – ‘SC 13G/A’ on 2/11/02 re: Celldex Therapeutics, Inc.

On: Monday, 2/11/02 · Accession #: 1005477-2-428 · File #: 5-37761

  As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 2/11/02  Healthcare Ventures II LP         SC 13G/A               1:31K  Celldex Therapeutics, Inc.        CT EDGAR123/FA
          Harold R. Werner
          HealthCare Partners II, L.P.
          Healthcare Partners III L.P.
          HealthCare Partners IV, L.P.
          Healthcare Ventures III, L.P.
          Healthcare Ventures IV, L.P.
          James H. Cavanaugh, Ph.D.
          John W. Littlechild
          William Crouse

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: SC 13G/A    Amendment No.5 to Schedule 13G                        17     62K

Document Table of Contents

Page	(sequential)	\|	(alphabetic)	Top
			Alternative Formats (Word, et al.) Certification: Identification and Classification of Members of the Group: Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check whether the person filing is a: Notice of Dissolution of Group: Ownership Ownership of Five Percent or less of a Class: Ownership of More than Five Percent on Behalf of Another Person:
1	1st Page - Filing Submission
13	Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check whether the person filing is a:
"	Item 4. Ownership
14	Item 5. Ownership of Five Percent or less of a Class:
15	Item 6. Ownership of More than Five Percent on Behalf of Another Person:
"	Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company:
"	Item 8. Identification and Classification of Members of the Group:
"	Item 9. Notice of Dissolution of Group:
"	Item 10. Certification:

SC 13G/A 1st Page of 17 TOC ↑Top Previous Next ↓Bottom Just 1st
 
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G
(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS
 FILED PURSUANT TO RULES 13D-1 (b)(c), AND (d)
AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)

 (Amendment No. 5 )*

AVANT IMMUNOTHERAPEUTICS, INC.
--------------------------------------------------------------------------------
(Name of Issuer)

 Common Stock, $.001 par value
--------------------------------------------------------------------------------
(Title of Class of Securities)

 053491106
--------------------------------------------------------------------------------
(CUSIP Number)

 December 31, 2001
--------------------------------------------------------------------------------
 Date of Event Which Requires Filing of this Statement

  Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:                                                              

|_| Rule 13d-1(b) 

|_| Rule 13d-1(c) 

|X| Rule 13d-1(d) 

*     The remainder of this cover page shall be filled out for a reporting      
person's initial filing on this form with respect to the subject class of       
securities, and for any subsequent amendment containing information which would 
alter the disclosures provided in a prior cover page.                           

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of   
1934 ("Act") or otherwise subject to the liabilities of that section of the Act 
but shall be subject to all other provisions of the Act (however, see the       
Notes).                                                                         

(Continued on following page(s))
Page 1 of 17 Pages

SC 13G/A 2nd Page of 17 TOC 1st Previous Next ↓Bottom Just 2nd
CUSIP No. 053491106                   13G                     Page 2 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Ventures II, L.P.                                            
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          115,895                                                 
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

115,895                           
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

115,895                                                                 
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

.19%                                                                    
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 3rd Page of 17 TOC 1st Previous Next ↓Bottom Just 3rd
CUSIP No. 053491106                   13G                     Page 3 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Partners II, L.P.                                            
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          115,895                                                 
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

115,895                           
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

115,895                                                                 
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

.19%                                                                    
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 4th Page of 17 TOC 1st Previous Next ↓Bottom Just 4th
CUSIP No. 053491106                   13G                     Page 4 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Ventures III, L.P.                                           
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,046,908                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,046,908                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,046,908                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

3.39%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 5th Page of 17 TOC 1st Previous Next ↓Bottom Just 5th
CUSIP No. 053491106                   13G                     Page 5 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Partners III, L.P.                                           
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,046,908                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,046,908                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,046,908                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

3.39%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 6th Page of 17 TOC 1st Previous Next ↓Bottom Just 6th
CUSIP No. 053491106                   13G                     Page 6 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Ventures IV, L.P.                                            
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          601,099                                                 
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

601,099                           
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

601,099                                                                 
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

.99%                                                                    
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 7th Page of 17 TOC 1st Previous Next ↓Bottom Just 7th
CUSIP No. 053491106                   13G                     Page 7 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

HealthCare Partners IV, L.P.                                            
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

Delaware                                                                
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          601,099                                                 
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

601,099                           
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

601,099                                                                 
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

.99%                                                                    
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

PN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 8th Page of 17 TOC 1st Previous Next ↓Bottom Just 8th
CUSIP No. 053491106                   13G                     Page 8 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

James H. Cavanaugh, Ph.D.                                               
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

United States                                                           
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,763,902                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,763,902                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,763,902                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

4.57%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

IN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 9th Page of 17 TOC 1st Previous Next ↓Bottom Just 9th
CUSIP No. 053491106                   13G                     Page 9 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

Harold R. Werner                                                        
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

United States                                                           
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,763,902                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,763,902                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,763,902                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

4.57%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

IN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 10th Page of 17 TOC 1st Previous Next ↓Bottom Just 10th
CUSIP No. 053491106                   13G                    Page 10 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

William Crouse                                                          
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

United States                                                           
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,763,902                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,763,902                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,763,902                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

4.57%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

IN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 11th Page of 17 TOC 1st Previous Next ↓Bottom Just 11th
CUSIP No. 053491106                   13G                    Page 11 of 17 Pages
--------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON                                                    
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                       

John W. Littlechild                                                     
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                           
                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3   SEC USE ONLY                                                                

--------------------------------------------------------------------------------
4   CITIZENSHIP OR PLACE OF ORGANIZATION                                        

United States                                                           
--------------------------------------------------------------------------------
5    SOLE VOTING POWER                      

                  --------------------------------------------------------------
NUMBER OF       6    SHARED VOTING POWER                                    
SHARES                                                                  
BENEFICIALLY          2,763,902                                               
   OWNED BY       --------------------------------------------------------------
EACH         7    SOLE DISPOSITIVE POWER                              
REPORTING                                                                   
PERSON                                                                  
     WITH         --------------------------------------------------------------
8    SHARED DISPOSITIVE POWER               

2,763,902                         
--------------------------------------------------------------------------------
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                

2,763,902                                                               
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*       

                                                                           |_|
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                           

4.57%                                                                   
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                                   

IN                                                                      
--------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT  

SC 13G/A 12th Page of 17 TOC 1st Previous Next ↓Bottom Just 12th
Item 1.                                                                         

(a)   Name of Issuer:                                               

Avant Immunotherapeutics, Inc.                          

(b)   Address of Issuer's Principal Executive Offices:              

119 Fourth Avenue                                       
Needham, Massachusetts 02494-2725                       

Item 2.                                                                         

(a)   Name of Person Filing:                                        

        HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II,
   L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"),
          HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV,
     L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr.
    Cavanaugh and Messrs. Werner, Littlechild and Crouse(1). See
           attached Exhibit A which is a copy of their agreement in writing to
file this statement on behalf of each of them.          

(b)   Address of Principal Business Office or, if none, Residence:  

          The business address for HCV II, HCP II, HCV III, HCP III, HCV IV,
           HCP IV and Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau
            Street, Princeton, New Jersey 08542. The business address for Messr.
   Littlechild is One Kendall Square, Building 300, Cambridge,
Massachusetts 02139.                                    

(c)   Citizenship:                                                  

       HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are limited
           partnerships organized under the laws of the State of Delaware. Dr.
      Cavanaugh and Messrs. Werner, Littlechild, and Crouse are each
United States citizens.                                 

----------                                                                      

          (1)   Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are
                 general partners of HCP II, HCP III and HCP IV, which are the
                 general partners of HCV II, HCV III and HCV IV, respectively,
           the record holders of shares of the Issuer's securities
reported hereto.                            

SC 13G/A 13th Page of 17 TOC 1st Previous Next ↓Bottom Just 13th
                                                             Page 13 of 17 pages

(d)   Title of Class of Securities:                                 

Common Stock, par value $.001 (the "Shares").           

(e)   CUSIP Number:                                                 

053491106                                               

Item 3.     If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),  
check whether the person filing is a:                   

Inapplicable.                                           

Item 4.     Ownership.                                                          

(a)   Amount Beneficially Owned:                                    

     As of December 31, 2001: HCV II and HCP II beneficially owned
            115,895 Shares, all of which are immediately exercisable warrants to
            purchase the same number of Shares of the Issuer's Common Stock; HCV
          III and HCP III beneficially owned 2,046,908 Shares, consisting of
     1,753,971 Shares of the Issuer's Common Stock and immediately
       exercisable warrants to purchase 292,937 Shares of the Issuer's
          Common Stock; HCV IV and HCP IV beneficially owned 601,099 Shares,
     consisting of 515,074 Shares of the Issuer's Common Stock and
         immediately exercisable warrants to purchase 86,025 Shares of the
            Issuer's Common Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild
     and Crouse beneficially owned 2,763,902 Shares, consisting of
     2,269,045 Shares of the Issuer's Common Stock and immediately
       exercisable warrants to purchase 494,857 Shares of the Issuer's
Common Stock.                                           

(b)   Percent of Class:                                             

    As of December 31, 2001: the 115,895 immediately exercisable
      warrants to purchase the same number of Shares of the Issuer's
            Common Stock beneficially owned by HCV II and HCP II constitute .19%
            of Issuer's Shares outstanding; the 2,046,908 Shares, which includes
         the warrants to purchase the Shares of the Issuer's Common Stock,
         beneficially owned by HCV III and HCP III constitute 3.39% of the
           Issuer's Shares outstanding; the 601,099 Shares, which includes the
     warrants to purchase the Shares of the Issuer's Common Stock,
      beneficially owned by HCV IV and HCP IV constitute .99% of the
         Issuer's Shares outstanding; the 2,763,902 Shares, which includes
         the warrants to purchase the Shares of the Issuer's Common Stock,
           beneficially owned by Dr. Cavanaugh and Messrs. Werner, Littlechild
       and Crouse constitute 4.57% of the Issuer's Shares outstanding.

SC 13G/A 14th Page of 17 TOC 1st Previous Next ↓Bottom Just 14th
                                                             Page 14 of 17 pages

(c)   Number of shares as to which such person has:                 

(i)   sole power to vote or to direct the vote:         

Not applicable.                             

(ii)  shared power to vote or to direct the vote:       

                  HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild,
                  and Crouse share the power to vote or direct the vote of those
Shares owned by HCV II.                     

       HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                 Littlechild, and Crouse share the power to vote or direct the
vote of those Shares owned by HCV III.      

                  HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild,
                  and Crouse share the power to vote or direct the vote of those
Shares owned by HCV IV.                     

    (iii) sole power to dispose or to direct the disposition of:

Not applicable.                             

         (iv)  shared power to dispose of or to direct the disposition of:

        HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner and
           Littlechild share the power to dispose of or direct the
disposition of those Shares owned by HCV II.

       HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                  Littlechild and Crouse share the power to dispose of or direct
     the disposition of those Shares owned by HCV III.

                 HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild
          and Crouse share the power to dispose of or direct the
disposition of those Shares owned by HCV IV.

Item 5.     Ownership of Five Percent or less of a Class:                       

        This statement is being filed to report the fact that, as of the
           date hereof, the Reporting Persons have ceased to be the beneficial
         owner of more than five percent of the class of securities of the
Issuer.                                                 

SC 13G/A 15th Page of 17 TOC 1st Previous Next ↓Bottom Just 15th
                                                             Page 15 of 17 pages

Item 6.     Ownership of More than Five Percent on Behalf of Another Person:    

Inapplicable.                                           

Item 7.     Identification and Classification of the Subsidiary Which Acquired  
     the Security Being Reported on by the Parent Holding Company:

Inapplicable.                                           

Item 8.     Identification and Classification of Members of the Group:          

Inapplicable.                                           

Item 9.     Notice of Dissolution of Group:                                     

Inapplicable.                                           

Item 10.    Certification:                                                      

Inapplicable.                                           

SC 13G/A 16th Page of 17 TOC 1st Previous Next ↓Bottom Just 16th
                                                             Page 16 of 17 pages

SIGNATURES

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.                                                                        

                                                        [Enlarge/Download Table]
                                                                                       
Dated:  February 8, 2002          HealthCare Ventures II, L.P.,                        
        Princeton, New Jersey     by its General Partner, HealthCare Partners II, L.P. 

                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated:  February 8, 2002          HealthCare Partners II, L.P.                         
        Princeton, New Jersey                                                          
                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated: February 8, 2002           HealthCare Ventures III, L.P.,                       
       Princeton, New Jersey      by its General Partner, HealthCare Partners III, L.P.

                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated: February 8, 2002           HealthCare Partners III, L.P.                        
       Princeton, New Jersey                                                           
                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated: February 8, 2002           HealthCare Ventures IV, L.P.,                        
       Princeton, New Jersey      by its General Partner, HealthCare Partners IV, L.P. 

                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated: February 8, 2002           HealthCare Partners IV, L.P.                         
       Princeton, New Jersey                                                           
                                  By: /s/ Jeffrey Steinberg                            
                                      -------------------------------------------------
                                          Administrative Partner                       

Dated: February 8, 2002           By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Princeton, New Jersey          -------------------------------------------------
                                          James H. Cavanaugh, Ph.D.                    

Dated: February 8, 2002          By: /s/ Jeffrey Steinberg, Attorney-in-Fact           
       Princeton, New Jersey         --------------------------------------------------
                                          Harold R. Werner                             

Dated: February 8, 2002           By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Cambridge, Massachusetts       -------------------------------------------------
                                          John W. Littlechild                          

Dated: February 8, 2002           By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Princeton, New Jersey         --------------------------------------------------
                                          William Crouse                               

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 EXHIBIT A

 AGREEMENT

JOINT FILING OF SCHEDULE 13G

     The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto         
reporting each of the undersigned's ownership of securities of Avant            
Immunotherapeutics, Inc. and hereby affirm that such Schedule 13G is being filed
on behalf of each of the undersigned.                                           

                                                        [Enlarge/Download Table]
                                                                                      
Dated:  February 8, 2002         HealthCare Ventures II, L.P.,                        
        Princeton, New Jersey    by its General Partner, HealthCare Partners II, L.P. 

                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated:  February 8, 2002         HealthCare Partners II, L.P.                         
        Princeton, New Jersey                                                         
                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated: February 8, 2002          HealthCare Ventures III, L.P.,                       
       Princeton, New Jersey     by its General Partner, HealthCare Partners III, L.P.

                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated: February 8, 2002          HealthCare Partners III, L.P.                        
       Princeton, New Jersey                                                          
                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated: February 8, 2002          HealthCare Ventures IV, L.P.,                        
       Princeton, New Jersey     by its General Partner, HealthCare Partners IV, L.P. 

                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated: February 8, 2002          HealthCare Partners IV, L.P.                         
       Princeton, New Jersey                                                          
                                 By: /s/ Jeffrey Steinberg                            
                                     -------------------------------------------------
                                         Administrative Partner                       

Dated: February 8, 2002          By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Princeton, New Jersey         -------------------------------------------------
                                         James H. Cavanaugh, Ph.D.                    

Dated: February 8, 2002          By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Princeton, New Jersey        --------------------------------------------------
                                         Harold R. Werner                             

Dated: February 8, 2002          By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Cambridge, Massachusetts      -------------------------------------------------
                                         John W. Littlechild                          

Dated: February 8, 2002          By: /s/ Jeffrey Steinberg, Attorney-in-Fact          
       Princeton, New Jersey        --------------------------------------------------
                                         William Crouse

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Dates Referenced Herein and Documents Incorporated by Reference

		Referenced-On Page
This ‘SC 13G/A’ Filing	Date	First	Last	Other Filings

Filed on:	2/11/02
	2/8/02	16	17
	12/31/01	1	13	10-K
				List all Filings

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Filing Submission 0001005477-02-000428 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Healthcare Ventures II LP, et al. – ‘SC 13G/A’ on 2/11/02 re: Celldex Therapeutics, Inc.

On: Monday, 2/11/02 · Accession #: 1005477-2-428 · File #: 5-37761

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Amendment to Statement of Beneficial Ownership — Schedule 13GFiling Table of Contents

Document Table of Contents

Dates Referenced Herein and Documents Incorporated by Reference

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents