SEC Info - Opthea Ltd. - ‘20-F’ for 6/30/23

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Opthea Ltd. – ‘20-F’ for 6/30/23 – ‘EX-101.PRE’

On: Thursday, 9/28/23, at 6:17am ET · For: 6/30/23 · Accession #: 950170-23-50230 · File #: 1-39621

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 9/28/23  Opthea Ltd.                       20-F        6/30/23  155:31M                                    Donnelley … Solutions/FA

Annual or Annual-Transition Report by a Foreign Non-Canadian Issuer — Form 20-F — SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 20-F        Annual or Annual-Transition Report by a Foreign     HTML   6.60M 
                Non-Canadian Issuer                                              
 3: EX-4.16     Instrument Defining the Rights of Security Holders  HTML    228K 
 2: EX-4.5      Instrument Defining the Rights of Security Holders  HTML    383K 
 6: EX-13.1     Annual or Quarterly Report to Security Holders      HTML     45K 
 4: EX-12.1     Statement re: the Computation of Ratios             HTML     47K 
 5: EX-12.2     Statement re: the Computation of Ratios             HTML     47K 
 7: EX-15.1     Letter re: Unaudited Interim Financial Info         HTML     42K 
13: R1          Document and Entity Information                     HTML    122K 
14: R2          Consolidated Statements of Profit or Loss and       HTML    107K 
                Other Comprehensive Income                                       
15: R3          Consolidated Statements of Financial Position       HTML    107K 
16: R4          Consolidated Statements of Financial Position       HTML     43K 
                (Parenthetical)                                                  
17: R5          Consolidated Statements of Stockholders' Equity     HTML     75K 
18: R6          Consolidated Statements of Stockholders' Equity     HTML     47K 
                (Parenthetical)                                                  
19: R7          Consolidated Statements of Cash Flows               HTML     87K 
20: R8          Reporting Entity                                    HTML     44K 
21: R9          Basis of Accounting                                 HTML     63K 
22: R10         Summary of Accounting Policies                      HTML    115K 
23: R11         Critical Accounting Judgments and Key Sources of    HTML     70K 
                Estimation Uncertainty                                           
24: R12         Application of New and Revised Accounting           HTML     47K 
                Standards                                                        
25: R13         Segment Information                                 HTML     48K 
26: R14         Revenue                                             HTML     67K 
27: R15         Other Income                                        HTML     67K 
28: R16         Research and Development Expenses                   HTML     68K 
29: R17         Expenses                                            HTML    185K 
30: R18         Finance Income                                      HTML     65K 
31: R19         Interest Expense on DFA                             HTML     65K 
32: R20         Fair Value Adjustment Gain on DFA                   HTML     68K 
33: R21         Net Foreign Exchange Loss                           HTML     72K 
34: R22         Income Taxes                                        HTML    242K 
35: R23         Earnings per Share                                  HTML    172K 
36: R24         Current Assets - Cash and Cash Equivalents          HTML     65K 
37: R25         Current Assets - Receivables                        HTML     67K 
38: R26         Current Assets - Prepayments                        HTML     66K 
39: R27         Non-Current Assets - Right of Use Assets            HTML    128K 
40: R28         Non-Current Assets - Prepayments                    HTML     59K 
41: R29         Current Liabilities - Payables                      HTML     64K 
42: R30         Current Liabilities - Provisions                    HTML     62K 
43: R31         Lease Liabilities                                   HTML    101K 
44: R32         Non-Current Liabilities - Financial Liabilities     HTML     81K 
45: R33         Non-Current Liabilities - Provisions                HTML     59K 
46: R34         Contributed Equity                                  HTML    152K 
47: R35         Accumulated Losses and Reserves                     HTML    143K 
48: R36         Financial Risk Management Objectives and Policies   HTML    227K 
49: R37         Related Party Disclosures                           HTML    104K 
50: R38         Commitments                                         HTML    106K 
51: R39         Contingencies                                       HTML     48K 
52: R40         Cash Flow Statements Reconciliation                 HTML    172K 
53: R41         Key Management Personnel                            HTML     79K 
54: R42         Share-Based Payments                                HTML    857K 
55: R43         Events After the Balance Sheet Date                 HTML     54K 
56: R44         Summary of Accounting Policies (Policies)           HTML    142K 
57: R45         Revenue (Tables)                                    HTML     67K 
58: R46         Other Income (Tables)                               HTML     67K 
59: R47         Research and Development Expenses (Tables)          HTML     67K 
60: R48         Expenses (Tables)                                   HTML    184K 
61: R49         Finance Income (Tables)                             HTML     64K 
62: R50         Interest Expense on DFA (Tables)                    HTML     64K 
63: R51         Fair Value Adjustment Gain on DFA (Tables)          HTML     64K 
64: R52         Net Foreign Exchange Loss (Tables)                  HTML     68K 
65: R53         Income Taxes (Tables)                               HTML    237K 
66: R54         Earnings per Share (Tables)                         HTML    171K 
67: R55         Current Assets - Cash and Cash Equivalents          HTML     62K 
                (Tables)                                                         
68: R56         Current Assets - Receivables (Tables)               HTML     67K 
69: R57         Non-Current Assets - Right of Use Assets (Tables)   HTML    128K 
70: R58         Current Assets - Prepayments (Tables)               HTML     65K 
71: R59         Non-Current Assets - Prepayments (Tables)           HTML     58K 
72: R60         Current Liabilities - Payables (Tables)             HTML     63K 
73: R61         Current Liabilities - Provisions (Tables)           HTML     62K 
74: R62         Lease Liabilities (Tables)                          HTML     98K 
75: R63         Non-Current Liabilities - Financial Liabilities     HTML     68K 
                (Tables)                                                         
76: R64         Non-Current Liabilities - Provisions (Tables)       HTML     58K 
77: R65         Contributed Equity (Tables)                         HTML    124K 
78: R66         Accumulated Losses and Reserves (Tables)            HTML    138K 
79: R67         Financial Risk Management Objectives and Policies   HTML    209K 
                (Tables)                                                         
80: R68         Related Party Disclosures (Tables)                  HTML    102K 
81: R69         Commitments (Tables)                                HTML    104K 
82: R70         Cash Flow Statements Reconciliation (Tables)        HTML    171K 
83: R71         Key Management Personnel (Tables)                   HTML     77K 
84: R72         Share-Based Payments (Tables)                       HTML    849K 
85: R73         Basis of Accounting - Additional Information        HTML    101K 
                (Details)                                                        
86: R74         Summary of Accounting Policies - Additional         HTML     75K 
                Information (Details)                                            
87: R75         Critical Accounting Judgements and Key Sources of   HTML     66K 
                Estimation Uncertainty - Additional Information                  
                (Details)                                                        
88: R76         Segment Information - Additional Information        HTML     49K 
                (Details)                                                        
89: R77         Revenue - Summary of Revenue (Details)              HTML     49K 
90: R78         Other Income - Schedule of Other Income (Details)   HTML     46K 
91: R79         Research and Development Expenses - Summary of      HTML     46K 
                Research and Development Expenses (Details)                      
92: R80         Expenses - Summary of Expenses (Details)            HTML     87K 
93: R81         Finance Income - Summary of Finance Income          HTML     46K 
                (Details)                                                        
94: R82         Interest Expense on DFA - Summary of Interest       HTML     46K 
                Expense on DFA (Details)                                         
95: R83         Interest Expense on DFA - Additinal Information     HTML     43K 
                (Details)                                                        
96: R84         Fair Value Adjustment Gain on DFA - Summary of      HTML     43K 
                Fair Value Adjustment Gain on DFA (Details)                      
97: R85         Fair Value Adjustment Gain on DFA - Additional      HTML     45K 
                Information (Details)                                            
98: R86         Net Foreign Exchange Loss - Summary of Net Foreign  HTML     46K 
                Exchange Loss (Details)                                          
99: R87         Net Foreign Exchange Loss - Additional Information  HTML     51K 
                (Details)                                                        
100: R88         Income Taxes - Summary of Income Tax Benefit and    HTML     55K  
                Current Tax Receivable (Details)                                 
101: R89         Income Taxes - Summary of Reconciliation Between    HTML     59K  
                Income Tax Benefit and the Product of Accounting                 
                Loss Before Income Tax Multiplied by the Group's                 
                Applicable Income Tax Rate (Details)                             
102: R90         Income Taxes - Summary of Reconciliation Between    HTML     44K  
                Income Tax Benefit and the Product of Accounting                 
                Loss Before Income Tax Multiplied by the Group's                 
                Applicable Income Tax Rate (Parenthetical)                       
                (Details)                                                        
103: R91         Income Taxes - Summary of Recognized Deferred Tax   HTML     67K  
                Assets and Liabilities in Statement of Financial                 
                Position (Details)                                               
104: R92         Income Taxes - Additional Information (Details)     HTML     56K  
105: R93         Earnings Per Share - Summary of Income Used in      HTML     57K  
                Basic and Diluted Earnings Per Share Computation                 
                (Details)                                                        
106: R94         Earnings Per Share - Additional Information         HTML     69K  
                (Details)                                                        
107: R95         Earnings Per Share - Summary of Options Plans       HTML     59K  
                (Details)                                                        
108: R96         Current Assets - Cash and Cash Equivalents -        HTML     49K  
                Summary of Cash and Cash Equivalents (Details)                   
109: R97         Current Assets - Cash and Cash Equivalents -        HTML     51K  
                Additional Information (Details)                                 
110: R98         Current Assets - Receivables - Summary of Current   HTML     52K  
                Assets - Receivables (Details)                                   
111: R99         Current Assets - Receivables - Summary of Current   HTML     43K  
                Assets - Receivables (Parenthetical) (Details)                   
112: R100        Current Assets - Prepayments - Summary of Current   HTML     48K  
                Assets Prepayments (Details)                                     
113: R101        Non-Current Assets - Prepayments - Summary of       HTML     45K  
                Non-Current Assets - Prepayments (Details)                       
114: R102        Non-Current Assets - Right of Use Assets - Summary  HTML     53K  
                of Carrying Amount of Lease (Details)                            
115: R103        Non-Current Assets - Right of Use Assets -          HTML     43K  
                Additional Information (Details)                                 
116: R104        Non-Current Assets - Right of Use Assets - Summary  HTML     50K  
                of Lease Amounts Recognized in Profit or Loss                    
                (Details)                                                        
117: R105        Current Liabilities - Payables - Summary of         HTML     48K  
                Current Liabilities Payables (Details)                           
118: R106        Current Liabilities - Payables - Summary of         HTML     43K  
                Current Liabilities Payables (Parenthetical)                     
                (Details)                                                        
119: R107        Current Liabilities - Payables - Additional         HTML     46K  
                Information (Details)                                            
120: R108        Current Liabilities - Provisions - Summary of       HTML     47K  
                Current Provisions (Details)                                     
121: R109        Lease Liabilities - Additional Information          HTML     46K  
                (Details)                                                        
122: R110        Lease Liabilities - Summary of Lease Liabilities    HTML     62K  
                (Details)                                                        
123: R111        Non-Current Liabilities - Lease Liabilities -       HTML     44K  
                Summary of Non-Current Liabilities - Lease                       
                Liabilities (Details)                                            
124: R112        Non-Current Liabilities - Financial Liabilities -   HTML     49K  
                Summary of Noncurrent Financial Liabilities                      
                (Details)                                                        
125: R113        Non-Current Liabilities - Financial Liabilities -   HTML     69K  
                Additional Information (Details)                                 
126: R114        Non-Current Liabilities - Provisions - Summary of   HTML     45K  
                Non-Current Liabilities - Provisions (Details)                   
127: R115        Contributed Equity - Summary of Contributed Equity  HTML     73K  
                (Details)                                                        
128: R116        Contributed Equity - Summary of Contributed Equity  HTML     48K  
                (Parenthetical) (Details)                                        
129: R117        Contributed Equity - Additional Information         HTML     98K  
                (Details)                                                        
130: R118        Accumulated Losses and Reserves - Summary of        HTML     78K  
                Accumulated Losses and Reserves (Details)                        
131: R119        Financial Risk Management Objectives and Policies   HTML     57K  
                - Summary of Judgments of Reasonably Possible                    
                Movements (Details)                                              
132: R120        Financial Risk Management Objectives and Policies   HTML     46K  
                - Summary of Judgments of Reasonably Possible                    
                Movements (Parenthetical) (Details)                              
133: R121        Financial Risk Management Objectives and Policies   HTML     61K  
                - Additional Information (Details)                               
134: R122        Financial Risk Management Objectives and Policies   HTML     66K  
                - Summary of Exposure to Foreign Currency Risk                   
                (Details)                                                        
135: R123        Related Party Disclosures - Summary of              HTML     48K  
                Consolidated Financial Statements Include                        
                Financial Statements of Opthea Limited and                       
                Subsidiaries (Details)                                           
136: R124        Related Party Disclosures - Summary of Trading      HTML     49K  
                Transactions with Related Parties (Details)                      
137: R125        Related Party Disclosures - Additional Information  HTML     45K  
                (Details)                                                        
138: R126        Commitments - Summary of Expenditure Commitments    HTML     51K  
                Relating to Services for Clinical Trial and                      
                Intellectual Property License Agreements (Details)               
139: R127        Commitments - Additional Information (Details)      HTML     48K  
140: R128        Commitments - Summary of Commercial Commitments     HTML     45K  
                (Details)                                                        
141: R129        Contingencies - Additional Information (Details)    HTML     50K  
142: R130        Cash Flow Statements Reconciliation - Summary of    HTML     94K  
                Cash Flow Statements Reconciliation (Details)                    
143: R131        Key Management Personnel - Schedule of              HTML     51K  
                Compensation of Key Management Personnel (Details)               
144: R132        Key Management Personnel - Additional Information   HTML     45K  
                (Details)                                                        
145: R133        Share-Based Payments - Summary of Recognized Share  HTML     44K  
                Based Payment Expenses (Details)                                 
146: R134        Share-Based Payments - Additional Information       HTML     61K  
                (Details)                                                        
147: R135        Share-Based Payments - Summary of Fair Value of     HTML    339K  
                Share Options Granted (Details)                                  
148: R136        Share-Based Payments - Summary of Share/Rights      HTML     67K  
                Options Outstanding (Details)                                    
149: R137        Share-Based Payments - Summary of ADS Options       HTML     74K  
                Outstanding (Details)                                            
150: R138        Events After The Balance Sheet Date - Additional    HTML    101K  
                Information (Details)                                            
153: XML         IDEA XML File -- Filing Summary                      XML    307K  
151: XML         XBRL Instance -- opt-20230630_htm                    XML   6.73M  
152: EXCEL       IDEA Workbook of Financial Report Info              XLSX    255K  
11: EX-101.CAL  XBRL Calculations -- opt-20230630_cal                XML    214K 
12: EX-101.DEF  XBRL Definitions -- opt-20230630_def                 XML    962K 
10: EX-101.LAB  XBRL Labels -- opt-20230630_lab                      XML   2.02M 
 8: EX-101.PRE  XBRL Presentations -- opt-20230630_pre               XML   1.53M 
 9: EX-101.SCH  XBRL Schema -- opt-20230630                          XSD    472K 
154: JSON        XBRL Instance as JSON Data -- MetaLinks              514±   811K  
155: ZIP         XBRL Zipped Folder -- 0000950170-23-050230-xbrl      Zip   3.69M

‘EX-101.PRE’ — XBRL Presentations — opt-20230630_pre

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NonadjustingEventsMember" xlink:label="ifrs-full_NonadjustingEventsMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_EventsAfterReportingPeriodMember" xlink:label="opt_EventsAfterReportingPeriodMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CounterpartiesAxis" xlink:label="ifrs-full_CounterpartiesAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:label="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss" xlink:label="ifrs-full_ProfitLoss"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:label="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ServiceConcessionArrangementsAxis" xlink:label="ifrs-full_ServiceConcessionArrangementsAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ServiceConcessionArrangementsMember" xlink:label="ifrs-full_ServiceConcessionArrangementsMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_DevelopmentFundingAgreementMember" xlink:label="opt_DevelopmentFundingAgreementMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RangesMember" xlink:label="ifrs-full_RangesMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_BottomOfRangeMember" xlink:label="ifrs-full_BottomOfRangeMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RangeAxis" xlink:label="ifrs-full_RangeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="ifrs-full_ClassesOfShareCapitalAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" xlink:label="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_BasisOfAccountingAbstract" xlink:label="opt_BasisOfAccountingAbstract"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_SecondTrancheMember" xlink:label="opt_SecondTrancheMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivities"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PrivatePlacementOfOrdinarySharesPIPEMember" xlink:label="opt_PrivatePlacementOfOrdinarySharesPIPEMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TopOfRangeMember" xlink:label="ifrs-full_TopOfRangeMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_ThirdTrancheMember" xlink:label="opt_ThirdTrancheMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets" xlink:label="ifrs-full_CurrentAssets"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssetsLiabilities" xlink:label="ifrs-full_CurrentAssetsLiabilities"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AmountCommittedByInvestor" xlink:label="opt_AmountCommittedByInvestor"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PipelineFundingInitialPayment" xlink:label="opt_PipelineFundingInitialPayment"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PipelineFundingAdditionalPayment" xlink:label="opt_PipelineFundingAdditionalPayment"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PipelineFundingAdditionalPaymentDiscription" xlink:label="opt_PipelineFundingAdditionalPaymentDiscription"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PipelineFundingPayment" xlink:label="opt_PipelineFundingPayment"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashOnHand" xlink:label="ifrs-full_CashOnHand"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AmountExpectedUnderFundingAgreement" xlink:label="opt_AmountExpectedUnderFundingAgreement"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_NumberOfTranches" xlink:label="opt_NumberOfTranches"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssueOfOrdinaryShares" xlink:label="ifrs-full_ProceedsFromIssueOfOrdinaryShares"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NumberOfSharesIssued" xlink:label="ifrs-full_NumberOfSharesIssued"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfShareCapitalMember" xlink:to="ifrs-full_OrdinarySharesMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CounterpartiesMember" xlink:to="opt_FirstTrancheMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NonadjustingEventsMember" xlink:to="opt_EventsAfterReportingPeriodMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CounterpartiesAxis" xlink:to="ifrs-full_CounterpartiesMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_ProfitLoss" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:to="ifrs-full_ServiceConcessionArrangementsAxis" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ServiceConcessionArrangementsMember" xlink:to="opt_DevelopmentFundingAgreementMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangesMember" xlink:to="ifrs-full_BottomOfRangeMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangeAxis" xlink:to="ifrs-full_RangesMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ServiceConcessionArrangementsAxis" xlink:to="ifrs-full_ServiceConcessionArrangementsMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" xlink:to="ifrs-full_NonadjustingEventsMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="opt_BasisOfAccountingAbstract" xlink:to="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CounterpartiesMember" xlink:to="opt_SecondTrancheMember" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_CashFlowsFromUsedInOperatingActivities" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:to="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ServiceConcessionArrangementsMember" xlink:to="opt_PrivatePlacementOfOrdinarySharesPIPEMember" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangesMember" xlink:to="ifrs-full_TopOfRangeMember" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="opt_BasisOfAccountingAbstract" xlink:to="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CounterpartiesMember" xlink:to="opt_ThirdTrancheMember" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_CashAndCashEquivalents" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:to="ifrs-full_CounterpartiesAxis" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_CurrentAssets" order="3" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:to="ifrs-full_RangeAxis" order="3" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_CurrentAssetsLiabilities" order="4" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationTable" xlink:to="ifrs-full_ClassesOfShareCapitalAxis" order="4" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_NetAssetsLiabilities" order="5" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_AmountCommittedByInvestor" order="6" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_PipelineFundingInitialPayment" order="7" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_PipelineFundingAdditionalPayment" order="8" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_PipelineFundingAdditionalPaymentDiscription" order="9" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_PipelineFundingPayment" order="10" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_ProceedsFromIssuingShares" order="11" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_CashOnHand" order="12" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_AmountExpectedUnderFundingAgreement" order="13" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="opt_NumberOfTranches" order="14" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_ProceedsFromIssueOfOrdinaryShares" order="15" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfReclassificationsOrChangesInPresentationLineItems" xlink:to="ifrs-full_NumberOfSharesIssued" order="16" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/Role_DisclosureSummaryOfAccountingPoliciesAdditionalInformationDetails" xlink:title="presentationLink" xlink:type="extended">

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:label="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PropertyPlantAndEquipmentMember" xlink:label="ifrs-full_PropertyPlantAndEquipmentMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EntitysTotalForSubsidiariesMember" xlink:label="ifrs-full_EntitysTotalForSubsidiariesMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AustralianDomiciledSubsidiaryMember" xlink:label="opt_AustralianDomiciledSubsidiaryMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesTable" xlink:label="opt_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesTable"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RangeAxis" xlink:label="ifrs-full_RangeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MethodsOfGenerationMember" xlink:label="ifrs-full_MethodsOfGenerationMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_ResearchAndDevelopmentTaxIncentiveSchemeMember" xlink:label="opt_ResearchAndDevelopmentTaxIncentiveSchemeMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesLineItems" xlink:label="opt_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesLineItems"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_ForeignCurrencyTranslationReserve" xlink:label="opt_ForeignCurrencyTranslationReserve"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MethodsOfGenerationAxis" xlink:label="ifrs-full_MethodsOfGenerationAxis"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_EquipmentAndFurnitureMember" xlink:label="opt_EquipmentAndFurnitureMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesAxis" xlink:label="ifrs-full_SignificantInvestmentsInSubsidiariesAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RangesMember" xlink:label="ifrs-full_RangesMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_OtherReceivableCollectionPeriod" xlink:label="opt_OtherReceivableCollectionPeriod"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LeaseholdImprovementsMember" xlink:label="ifrs-full_LeaseholdImprovementsMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_UnsecuredAmountPayablePaymentPeriod" xlink:label="opt_UnsecuredAmountPayablePaymentPeriod"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_UsefulLifeMeasuredAsPeriodOfTimePropertyPlantAndEquipment" xlink:label="ifrs-full_UsefulLifeMeasuredAsPeriodOfTimePropertyPlantAndEquipment"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Revenue" xlink:label="ifrs-full_Revenue"/>

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromRoyalties" xlink:label="ifrs-full_RevenueFromRoyalties"/>

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherIncome" xlink:label="ifrs-full_OtherIncome"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_ResearchProjectCosts" xlink:label="opt_ResearchProjectCosts"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_DepreciationLeaseholdImprovements" xlink:label="opt_DepreciationLeaseholdImprovements"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_Superannuation" xlink:label="opt_Superannuation"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_PayrollTax" xlink:label="opt_PayrollTax"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EmployeeBenefitsExpense" xlink:label="ifrs-full_EmployeeBenefitsExpense"/>

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingExpense" xlink:label="ifrs-full_MiscellaneousOtherOperatingExpense"/>

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</link:presentationLink>

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<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureNoncurrentAssetsRightOfUseAssetsAdditionalInformationDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseContractTerm" xlink:label="opt_LeaseContractTerm"/>

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</link:presentationLink>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AmountsRecognizedInProfitAndLossAbstract" xlink:label="opt_AmountsRecognizedInProfitAndLossAbstract"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DepreciationRightofuseAssets" xlink:label="ifrs-full_DepreciationRightofuseAssets"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FinanceCosts" xlink:label="ifrs-full_FinanceCosts"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ExpenseRelatingToLeasesOfLowvalueAssetsForWhichRecognitionExemptionHasBeenUsed" xlink:label="ifrs-full_ExpenseRelatingToLeasesOfLowvalueAssetsForWhichRecognitionExemptionHasBeenUsed"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilityProfitLoss" xlink:label="opt_LeaseLiabilityProfitLoss"/>

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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="opt_AmountsRecognizedInProfitAndLossAbstract" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

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<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/Role_DisclosureCurrentLiabilitiesPayablesSummaryOfCurrentLiabilitiesPayablesDetails" xlink:title="presentationLink" xlink:type="extended">

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_CurrentLiabilitiesPayablesAbstract" xlink:label="opt_CurrentLiabilitiesPayablesAbstract"/>

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent" xlink:label="ifrs-full_CurrentTaxLiabilitiesCurrent"/>

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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="opt_CurrentLiabilitiesPayablesAbstract" xlink:to="ifrs-full_ShorttermBorrowings" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AccountsPayableSettlementTerms" xlink:label="opt_AccountsPayableSettlementTerms"/>

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</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureCurrentLiabilitiesPayablesAdditionalInformationDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_AmountDueToRelatedParty" xlink:label="opt_AmountDueToRelatedParty"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis"/>

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LaunchTxMember" xlink:label="opt_LaunchTxMember"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_CurrentLiabilitiesPayablesAbstract" xlink:label="opt_CurrentLiabilitiesPayablesAbstract"/>

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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:to="opt_LaunchTxMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

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<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/Role_DisclosureCurrentLiabilitiesProvisionsSummaryOfCurrentProvisionsDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_CurrentProvisionsForLongServiceLeave" xlink:label="opt_CurrentProvisionsForLongServiceLeave"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentProvisionsAbstract" xlink:to="opt_CurrentProvisionsForAnnualLeave" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentProvisionsAbstract" xlink:to="opt_CurrentProvisionsForLongServiceLeave" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentProvisionsAbstract" xlink:to="ifrs-full_CurrentProvisions" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>

</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureLeaseLiabilitiesAdditionalInformationDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_WeightedAverageLesseesIncrementalBorrowingRateAppliedToLeaseLiabilitiesRecognisedAtDateOfInitialApplicationOfIFRS16" xlink:label="ifrs-full_WeightedAverageLesseesIncrementalBorrowingRateAppliedToLeaseLiabilitiesRecognisedAtDateOfInitialApplicationOfIFRS16"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="opt_LeaseLiabilitiesTerm" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="ifrs-full_WeightedAverageLesseesIncrementalBorrowingRateAppliedToLeaseLiabilitiesRecognisedAtDateOfInitialApplicationOfIFRS16" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureLeaseLiabilitiesSummaryOfLeaseLiabilitiesDetails" xlink:title="presentationLink" xlink:type="extended">

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesCarryingAmount" xlink:label="opt_LeaseLiabilitiesCarryingAmount"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilityNewLease" xlink:label="opt_LeaseLiabilityNewLease"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesPayments" xlink:label="opt_LeaseLiabilitiesPayments"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesCarryingAmount" xlink:label="opt_LeaseLiabilitiesCarryingAmount_3"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesMaturityAnalysisYearOne" xlink:label="opt_LeaseLiabilitiesMaturityAnalysisYearOne"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesMaturityAnalysisYearTwo" xlink:label="opt_LeaseLiabilitiesMaturityAnalysisYearTwo"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesMaturityAnalysis" xlink:label="opt_LeaseLiabilitiesMaturityAnalysis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities" xlink:label="ifrs-full_InterestExpenseOnLeaseLiabilities"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_LeaseLiabilitiesMaturityAnalysisNet" xlink:label="opt_LeaseLiabilitiesMaturityAnalysisNet"/>

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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="ifrs-full_CurrentLeaseLiabilities" order="9" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="ifrs-full_NoncurrentLeaseLiabilities" order="10" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_LeaseLiabilitiesAbstract" xlink:to="ifrs-full_LeaseLiabilities" order="11" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>

</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureNoncurrentLiabilitiesLeaseLiabilitiesSummaryOfNoncurrentLiabilitiesLeaseLiabilitiesDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NoncurrentProvisionsAbstract" xlink:to="ifrs-full_NoncurrentLeaseLiabilities_1" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>

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<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureNoncurrentLiabilitiesFinancialLiabilitiesSummaryOfNoncurrentFinancialLiabilitiesDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_NoncurrentFinancialLiabilitiesAtFairValue" xlink:label="opt_NoncurrentFinancialLiabilitiesAtFairValue"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_InterestExpenseOnDfa" xlink:label="opt_InterestExpenseOnDfa"/>

<link:loc xlink:type="locator" xlink:href="opt-20230630.xsd#opt_GainsLossesOnFairValueAdjustmentOnDfa" xlink:label="opt_GainsLossesOnFairValueAdjustmentOnDfa"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentFinancialLiabilities" xlink:label="ifrs-full_NoncurrentFinancialLiabilities"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfNoncurrentFinancialLiabilitiesAbstract" xlink:to="opt_NonCurrentFinancialLiabilitiesCarryingValue" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfNoncurrentFinancialLiabilitiesAbstract" xlink:to="opt_NoncurrentFinancialLiabilitiesAtFairValue" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfNoncurrentFinancialLiabilitiesAbstract" xlink:to="opt_InterestExpenseOnDfa" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>

<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfNoncurrentFinancialLiabilitiesAbstract" xlink:to="opt_GainsLossesOnFairValueAdjustmentOnDfa" order="3" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>

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</link:presentationLink>

<link:presentationLink xlink:role="http://opthea.com/20230630/taxonomy/role/DisclosureNoncurrentLiabilitiesFinancialLiabilitiesAdditionalInformationDetails" xlink:title="presentationLink" xlink:type="extended">

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<link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="ifrs-full_EntitysTotalForRelatedPartiesMember"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis"/>

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