Exhibit 32.1
CERTIFICATION PURSUANT TO
RULE 13a-14(b) OF THE SECURITIES EXCHANGE ACT OF 1934
AND 18 U.S.C. SECTION 1350
In connection with the periodic report of Connetics Corporation (the
“Registrant”) on Form
10-Q for the period ended
September 30, 2006, as filed with the Securities and Exchange Commission
on the date hereof (the
“Report”), I,
Thomas G. Wiggans, Chief Executive Officer of
the Registrant,
certify, in accordance with Rule 13a-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C.
Section 1350, that to the best of my knowledge:
(1) The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable,
of the Securities Exchange Act of 1934, and
(2) The information contained in the Report fairly presents, in all material respects, the
financial condition and results of operations of
the Registrant at the dates and for the periods
indicated.
This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the
Securities and Exchange Commission and is not to be incorporated by reference into any filing of
the Registrant under the Securities Act of 1933 or the Securities Exchange Act of 1934 (whether
made before or after the date of the Form 10-Q), irrespective of any general incorporation language
contained in such filing.
