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Pacira BioSciences, Inc. – ‘10-K’ for 12/31/12 – ‘EX-101.PRE’

On:  Thursday, 3/7/13, at 2:56pm ET   ·   For:  12/31/12   ·   Accession #:  1047469-13-2336   ·   File #:  1-35060

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/07/13  Pacira BioSciences, Inc.          10-K       12/31/12   87:9M                                     Toppan Merrill-FA

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML    979K 
 2: EX-10.47    Material Contract                                   HTML    318K 
 3: EX-10.48    Material Contract                                   HTML    163K 
 4: EX-21.1     Subsidiaries List                                   HTML     20K 
 5: EX-23.1     Consent of Experts or Counsel                       HTML     25K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 8: EX-32.1     Certification -- §906 - SOA'02                      HTML     24K 
 9: EX-32.2     Certification -- §906 - SOA'02                      HTML     24K 
59: R1          Document and Entity Information                     HTML     51K 
45: R2          Consolidated Balance Sheets                         HTML    144K 
57: R3          Consolidated Balance Sheets (Parenthetical)         HTML     49K 
61: R4          Consolidated Statements of Operations               HTML     90K 
80: R5          Consolidated Statements of Comprehensive Loss       HTML     48K 
48: R6          Consolidated Statements of Stockholders' Equity     HTML    135K 
                (Deficit)                                                        
56: R7          Consolidated Statements of Cash Flows               HTML    180K 
41: R8          Business                                            HTML     33K 
31: R9          Summary of Significant Accounting Policies          HTML     67K 
81: R10         Recent Accounting Pronouncements                    HTML     26K 
63: R11         Financial Instruments                               HTML     54K 
62: R12         Inventories                                         HTML     32K 
68: R13         Fixed Assets                                        HTML     38K 
69: R14         Goodwill and Intangible Assets                      HTML     55K 
66: R15         Accrued Expenses                                    HTML     31K 
70: R16         Debt                                                HTML     51K 
58: R17         Stockholders' Equity                                HTML     48K 
60: R18         Stock Plans                                         HTML     73K 
65: R19         Earnings Per Share                                  HTML     43K 
87: R20         Cost of Revenues                                    HTML     31K 
76: R21         Income Taxes                                        HTML     59K 
52: R22         Other Employee Benefits                             HTML     25K 
64: R23         Commercial Partners and Other Agreements            HTML     35K 
54: R24         Related Party Transactions                          HTML     35K 
23: R25         Commitments and Contingencies                       HTML     42K 
77: R26         Subsequent Events                                   HTML     26K 
84: R27         Summary of Significant Accounting Policies          HTML    145K 
                (Policies)                                                       
36: R28         Summary of Significant Accounting Policies          HTML     40K 
                (Tables)                                                         
35: R29         Financial Instruments (Tables)                      HTML     53K 
39: R30         Inventories (Tables)                                HTML     29K 
40: R31         Fixed Assets (Tables)                               HTML     33K 
42: R32         Goodwill and Intangible Assets (Tables)             HTML     52K 
21: R33         Accrued Expenses (Tables)                           HTML     30K 
74: R34         Debt (Tables)                                       HTML     35K 
50: R35         Stockholders' Equity (Tables)                       HTML     37K 
53: R36         Stock Plans (Tables)                                HTML     77K 
26: R37         Earnings Per Share (Tables)                         HTML     43K 
86: R38         Cost of Revenues (Tables)                           HTML     30K 
16: R39         Income Taxes (Tables)                               HTML     54K 
43: R40         Commitments and Contingencies (Tables)              HTML     29K 
79: R41         Summary of Significant Accounting Policies          HTML     29K 
                (Details)                                                        
25: R42         Summary of Significant Accounting Policies          HTML     43K 
                (Details 2)                                                      
34: R43         Summary of Significant Accounting Policies          HTML     31K 
                (Details 3)                                                      
38: R44         Financial Instruments (Details)                     HTML     26K 
46: R45         Financial Instruments (Details 2)                   HTML     47K 
20: R46         Financial Instruments (Details 3)                   HTML     31K 
30: R47         Inventories (Details)                               HTML     42K 
18: R48         Fixed Assets (Details)                              HTML     52K 
78: R49         Goodwill and Intangible Assets (Details)            HTML     44K 
24: R50         Goodwill and Intangible Assets (Details 2)          HTML     59K 
75: R51         Accrued Expenses (Details)                          HTML     36K 
27: R52         Debt (Details)                                      HTML    169K 
44: R53         Stockholders' Equity (Details)                      HTML     61K 
17: R54         Stockholders' Equity (Details 2)                    HTML     53K 
19: R55         Stock Plans (Details)                               HTML     37K 
37: R56         Stock Plans (Details 2)                             HTML     30K 
22: R57         Stock Plans (Details 3)                             HTML    117K 
82: R58         Earnings Per Share (Details)                        HTML     42K 
49: R59         Earnings Per Share (Details 2)                      HTML     33K 
67: R60         Cost of Revenues (Details)                          HTML     30K 
29: R61         Income Taxes (Details)                              HTML     79K 
32: R62         Income Taxes (Details 2)                            HTML     45K 
73: R63         Other Employee Benefits (Details)                   HTML     25K 
71: R64         Commercial Partners and Other Agreements (Details)  HTML     29K 
51: R65         Related Party Transactions (Details)                HTML     60K 
72: R66         Commitments and Contingencies (Details)             HTML     63K 
28: R67         Commitments and Contingencies (Details 2)           HTML     33K 
55: R68         Commitments and Contingencies (Details 3)           HTML     32K 
83: R69         Subsequent Events (Details)                         HTML     42K 
85: XML         IDEA XML File -- Filing Summary                      XML    125K 
33: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS    909K 
10: EX-101.INS  XBRL Instance -- pcrx-20121231                       XML   1.48M 
12: EX-101.CAL  XBRL Calculations -- pcrx-20121231_cal               XML    258K 
15: EX-101.DEF  XBRL Definitions -- pcrx-20121231_def                XML    769K 
13: EX-101.LAB  XBRL Labels -- pcrx-20121231_lab                     XML   3.14M 
14: EX-101.PRE  XBRL Presentations -- pcrx-20121231_pre              XML   1.39M 
11: EX-101.SCH  XBRL Schema -- pcrx-20121231                         XSD    250K 
47: ZIP         XBRL Zipped Folder -- 0001047469-13-002336-xbrl      Zip    232K

‘EX-101.PRE’   —   XBRL Presentations — pcrx-20121231_pre

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TrancheBOfTermLoanMember" xlink:label="TrancheBOfTermLoanMember" xlink:title="TrancheBOfTermLoanMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="HerculesTermLoanMember" xlink:to="TrancheBOfTermLoanMember" xlink:title="presentation: HerculesTermLoanMember to TrancheBOfTermLoanMember" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TwoThousandTenConvertibleNotesMember" xlink:label="TwoThousandTenConvertibleNotesMember" xlink:title="TwoThousandTenConvertibleNotesMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentNameDomain" xlink:to="TwoThousandTenConvertibleNotesMember" xlink:title="presentation: DebtInstrumentNameDomain to TwoThousandTenConvertibleNotesMember" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TwoThousandNineConvertibleNotesMember" xlink:label="TwoThousandNineConvertibleNotesMember" xlink:title="TwoThousandNineConvertibleNotesMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentNameDomain" xlink:to="TwoThousandNineConvertibleNotesMember" xlink:title="presentation: DebtInstrumentNameDomain to TwoThousandNineConvertibleNotesMember" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TwoThousandNineSecuredNotesMember" xlink:label="TwoThousandNineSecuredNotesMember" xlink:title="TwoThousandNineSecuredNotesMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentNameDomain" xlink:to="TwoThousandNineSecuredNotesMember" xlink:title="presentation: DebtInstrumentNameDomain to TwoThousandNineSecuredNotesMember" order="8002.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TwoThousandTenSecuredNotesMember" xlink:label="TwoThousandTenSecuredNotesMember" xlink:title="TwoThousandTenSecuredNotesMember"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_HbmSecuredNotesMember" xlink:label="HbmSecuredNotesMember" xlink:title="HbmSecuredNotesMember"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_GeneralElectricCapitalCorporationCreditFacilityMember" xlink:label="GeneralElectricCapitalCorporationCreditFacilityMember" xlink:title="GeneralElectricCapitalCorporationCreditFacilityMember"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongtermDebtCurrentAndNoncurrentAbstract" xlink:label="LongtermDebtCurrentAndNoncurrentAbstract" xlink:title="LongtermDebtCurrentAndNoncurrentAbstract"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="LongTermDebtCurrent" xlink:title="LongTermDebtCurrent"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LongtermDebtCurrentAndNoncurrentAbstract" xlink:to="LongTermDebtCurrent" xlink:title="presentation: LongtermDebtCurrentAndNoncurrentAbstract to LongTermDebtCurrent" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LongTermDebtNoncurrentGross" xlink:label="LongTermDebtNoncurrentGross" xlink:title="LongTermDebtNoncurrentGross"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LongtermDebtCurrentAndNoncurrentAbstract" xlink:to="LongTermDebtNoncurrentGross" xlink:title="presentation: LongtermDebtCurrentAndNoncurrentAbstract to LongTermDebtNoncurrentGross" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="DebtInstrumentUnamortizedDiscount" xlink:title="DebtInstrumentUnamortizedDiscount"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebt" xlink:label="LongTermDebt" xlink:title="LongTermDebt"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RoyaltyInterestObligationAbstract" xlink:label="RoyaltyInterestObligationAbstract" xlink:title="RoyaltyInterestObligationAbstract"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RoyaltyInterestObligationCurrent" xlink:label="RoyaltyInterestObligationCurrent" xlink:title="RoyaltyInterestObligationCurrent"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RoyaltyInterestObligationNoncurrent" xlink:label="RoyaltyInterestObligationNoncurrent" xlink:title="RoyaltyInterestObligationNoncurrent"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RoyaltyInterestObligation" xlink:label="RoyaltyInterestObligation" xlink:title="RoyaltyInterestObligation"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LongTermDebtIncludingRoyaltyInterestObligation" xlink:label="LongTermDebtIncludingRoyaltyInterestObligation" xlink:title="LongTermDebtIncludingRoyaltyInterestObligation"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="LineOfCreditFacilityMaximumBorrowingCapacity" xlink:title="LineOfCreditFacilityMaximumBorrowingCapacity"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityIncreaseAdditionalBorrowings" xlink:label="LineOfCreditFacilityIncreaseAdditionalBorrowings" xlink:title="LineOfCreditFacilityIncreaseAdditionalBorrowings"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentIncreaseAdditionalBorrowings" xlink:label="DebtInstrumentIncreaseAdditionalBorrowings" xlink:title="DebtInstrumentIncreaseAdditionalBorrowings"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="DebtInstrumentInterestRateStatedPercentage" xlink:title="DebtInstrumentInterestRateStatedPercentage"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_NumberOfEqualMonthlyPayments" xlink:label="NumberOfEqualMonthlyPayments" xlink:title="NumberOfEqualMonthlyPayments"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_AdditionalLoanPaymentAsAPercentageOfLoanFacilityOnMaturityDate" xlink:label="AdditionalLoanPaymentAsAPercentageOfLoanFacilityOnMaturityDate" xlink:title="AdditionalLoanPaymentAsAPercentageOfLoanFacilityOnMaturityDate"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentDecreaseRepayments" xlink:label="DebtInstrumentDecreaseRepayments" xlink:title="DebtInstrumentDecreaseRepayments"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty" xlink:label="DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty" xlink:title="DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty" xlink:title="presentation: DebtInstrumentLineItems to DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty" use="optional" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_DebtInstrumentProceedsUsedToRepayEndOfTermFee" xlink:label="DebtInstrumentProceedsUsedToRepayEndOfTermFee" xlink:title="DebtInstrumentProceedsUsedToRepayEndOfTermFee"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="DebtInstrumentProceedsUsedToRepayEndOfTermFee" xlink:title="presentation: DebtInstrumentLineItems to DebtInstrumentProceedsUsedToRepayEndOfTermFee" use="optional" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="GainsLossesOnExtinguishmentOfDebt" xlink:title="GainsLossesOnExtinguishmentOfDebt"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="GainsLossesOnExtinguishmentOfDebt" xlink:title="presentation: DebtInstrumentLineItems to GainsLossesOnExtinguishmentOfDebt" use="optional" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_DebtDefaultIncreaseInInterestRate" xlink:label="DebtDefaultIncreaseInInterestRate" xlink:title="DebtDefaultIncreaseInInterestRate"/>
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<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:title="presentation: DebtInstrumentLineItems to ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" use="optional" order="21.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_DebtInstrumentVariableRateBaseRate" xlink:label="DebtInstrumentVariableRateBaseRate" xlink:title="DebtInstrumentVariableRateBaseRate"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="DebtInstrumentInterestRateEffectivePercentage" xlink:title="DebtInstrumentInterestRateEffectivePercentage"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_AmountToBeRaisedOnSaleOfRoyaltyInterest" xlink:label="AmountToBeRaisedOnSaleOfRoyaltyInterest" xlink:title="AmountToBeRaisedOnSaleOfRoyaltyInterest"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest" xlink:label="NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest" xlink:title="NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_NetPresentValueOfRoyaltiesExpectedToBeRepaid" xlink:label="NetPresentValueOfRoyaltiesExpectedToBeRepaid" xlink:title="NetPresentValueOfRoyaltiesExpectedToBeRepaid"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PurchaseOptionEventPeriodWithinWhichRightIsExercisableWhichRequiresEntityToRepurchaseRoyaltyInterestAssignment" xlink:label="PurchaseOptionEventPeriodWithinWhichRightIsExercisableWhichRequiresEntityToRepurchaseRoyaltyInterestAssignment" xlink:title="PurchaseOptionEventPeriodWithinWhichRightIsExercisableWhichRequiresEntityToRepurchaseRoyaltyInterestAssignment"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PurchaseOptionEventPeriodForCalculationOfRepurchasePrice" xlink:label="PurchaseOptionEventPeriodForCalculationOfRepurchasePrice" xlink:title="PurchaseOptionEventPeriodForCalculationOfRepurchasePrice"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_TerminationPeriodOfWarrants" xlink:label="TerminationPeriodOfWarrants" xlink:title="TerminationPeriodOfWarrants"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentDescriptionOfVariableRateBasis" xlink:label="DebtInstrumentDescriptionOfVariableRateBasis" xlink:title="DebtInstrumentDescriptionOfVariableRateBasis"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_DebtInstrumentCarryingAmountNetOfDiscount" xlink:label="DebtInstrumentCarryingAmountNetOfDiscount" xlink:title="DebtInstrumentCarryingAmountNetOfDiscount"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PercentageOfPrepaymentCharge" xlink:label="PercentageOfPrepaymentCharge" xlink:title="PercentageOfPrepaymentCharge"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredFinanceCostsGross" xlink:label="DeferredFinanceCostsGross" xlink:title="DeferredFinanceCostsGross"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="AmortizationOfFinancingCosts" xlink:title="AmortizationOfFinancingCosts"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PercentageOfSharesOfSurvivingEntityWhichHoldersOfCapitalStockCeasesToRetainResultingInEventOfDefault" xlink:label="PercentageOfSharesOfSurvivingEntityWhichHoldersOfCapitalStockCeasesToRetainResultingInEventOfDefault" xlink:title="PercentageOfSharesOfSurvivingEntityWhichHoldersOfCapitalStockCeasesToRetainResultingInEventOfDefault"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_FirstMinimumRevenueReceivedInLockboxRestrictedAndWillBeUsedForQuarterlyPayments" xlink:label="FirstMinimumRevenueReceivedInLockboxRestrictedAndWillBeUsedForQuarterlyPayments" xlink:title="FirstMinimumRevenueReceivedInLockboxRestrictedAndWillBeUsedForQuarterlyPayments"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PeriodForWhichFirstMinimumRevenueReceivedInLockboxWillBeRestrictedAndUsedForQuarterlyPayments" xlink:label="PeriodForWhichFirstMinimumRevenueReceivedInLockboxWillBeRestrictedAndUsedForQuarterlyPayments" xlink:title="PeriodForWhichFirstMinimumRevenueReceivedInLockboxWillBeRestrictedAndUsedForQuarterlyPayments"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RestrictedCashAndCashEquivalentsHeldInLockBox" xlink:label="RestrictedCashAndCashEquivalentsHeldInLockBox" xlink:title="RestrictedCashAndCashEquivalentsHeldInLockBox"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="RestrictedCashAndCashEquivalentsHeldInLockBox" xlink:title="presentation: DebtInstrumentLineItems to RestrictedCashAndCashEquivalentsHeldInLockBox" use="optional" order="8009.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LineOfCreditFacilityPeriodOverWhichEqualPrincipalPaymentsWillBeMade" xlink:label="LineOfCreditFacilityPeriodOverWhichEqualPrincipalPaymentsWillBeMade" xlink:title="LineOfCreditFacilityPeriodOverWhichEqualPrincipalPaymentsWillBeMade"/>
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<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LineOfCreditFacilityPeriodFromTheFundingDatesUptoWhichEqualPrincipalPaymentsWillBeMade" xlink:label="LineOfCreditFacilityPeriodFromTheFundingDatesUptoWhichEqualPrincipalPaymentsWillBeMade" xlink:title="LineOfCreditFacilityPeriodFromTheFundingDatesUptoWhichEqualPrincipalPaymentsWillBeMade"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="LineOfCreditFacilityPeriodFromTheFundingDatesUptoWhichEqualPrincipalPaymentsWillBeMade" xlink:title="presentation: DebtInstrumentLineItems to LineOfCreditFacilityPeriodFromTheFundingDatesUptoWhichEqualPrincipalPaymentsWillBeMade" use="optional" order="8011.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LineOfCreditFacilityAggregateGuaranteeAmount" xlink:label="LineOfCreditFacilityAggregateGuaranteeAmount" xlink:title="LineOfCreditFacilityAggregateGuaranteeAmount"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="LineOfCreditFacilityAggregateGuaranteeAmount" xlink:title="presentation: DebtInstrumentLineItems to LineOfCreditFacilityAggregateGuaranteeAmount" use="optional" order="8012.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_CashlessExerciseOfWarrantsIssuedNumber" xlink:label="CashlessExerciseOfWarrantsIssuedNumber" xlink:title="CashlessExerciseOfWarrantsIssuedNumber"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentLineItems" xlink:to="CashlessExerciseOfWarrantsIssuedNumber" xlink:title="presentation: DebtInstrumentLineItems to CashlessExerciseOfWarrantsIssuedNumber" use="optional" order="8013.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeAxis" xlink:label="RangeAxis" xlink:title="RangeAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentTable" xlink:to="RangeAxis" xlink:title="presentation: DebtInstrumentTable to RangeAxis" use="optional" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeMember" xlink:label="RangeMember" xlink:title="RangeMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeAxis" xlink:to="RangeMember" xlink:title="presentation: RangeAxis to RangeMember" use="optional" order="8000.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MaximumMember" xlink:label="MaximumMember" xlink:title="MaximumMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeMember" xlink:to="MaximumMember" xlink:title="presentation: RangeMember to MaximumMember" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MinimumMember" xlink:label="MinimumMember" xlink:title="MinimumMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeMember" xlink:to="MinimumMember" xlink:title="presentation: RangeMember to MinimumMember" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd#dei_LegalEntityAxis" xlink:label="LegalEntityAxis" xlink:title="LegalEntityAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentTable" xlink:to="LegalEntityAxis" xlink:title="presentation: DebtInstrumentTable to LegalEntityAxis" use="optional" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd#dei_EntityDomain" xlink:label="EntityDomain" xlink:title="EntityDomain"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LegalEntityAxis" xlink:to="EntityDomain" xlink:title="presentation: LegalEntityAxis to EntityDomain" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_AffiliateOfPaulCapitalAdvisorsLLCMember" xlink:label="AffiliateOfPaulCapitalAdvisorsLLCMember" xlink:title="AffiliateOfPaulCapitalAdvisorsLLCMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="EntityDomain" xlink:to="AffiliateOfPaulCapitalAdvisorsLLCMember" xlink:title="presentation: EntityDomain to AffiliateOfPaulCapitalAdvisorsLLCMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="ClassOfWarrantOrRightAxis" xlink:title="ClassOfWarrantOrRightAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentTable" xlink:to="ClassOfWarrantOrRightAxis" xlink:title="presentation: DebtInstrumentTable to ClassOfWarrantOrRightAxis" use="optional" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="ClassOfWarrantOrRightDomain" xlink:title="ClassOfWarrantOrRightDomain"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantOrRightAxis" xlink:to="ClassOfWarrantOrRightDomain" xlink:title="presentation: ClassOfWarrantOrRightAxis to ClassOfWarrantOrRightDomain" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_WarrantsInConnectionWithLoanAgreementWithOxfordFinanceLLCToLenderMember" xlink:label="WarrantsInConnectionWithLoanAgreementWithOxfordFinanceLLCToLenderMember" xlink:title="WarrantsInConnectionWithLoanAgreementWithOxfordFinanceLLCToLenderMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="WarrantsInConnectionWithLoanAgreementWithOxfordFinanceLLCToLenderMember" xlink:title="presentation: ClassOfWarrantOrRightDomain to WarrantsInConnectionWithLoanAgreementWithOxfordFinanceLLCToLenderMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_WarrantsInConnectionWithDecember2010ConvertibleNotesMember" xlink:label="WarrantsInConnectionWithDecember2010ConvertibleNotesMember" xlink:title="WarrantsInConnectionWithDecember2010ConvertibleNotesMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="WarrantsInConnectionWithDecember2010ConvertibleNotesMember" xlink:title="presentation: ClassOfWarrantOrRightDomain to WarrantsInConnectionWithDecember2010ConvertibleNotesMember" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_WarrantsInConnectionWithHerculesCreditFacilityToLendersMember" xlink:label="WarrantsInConnectionWithHerculesCreditFacilityToLendersMember" xlink:title="WarrantsInConnectionWithHerculesCreditFacilityToLendersMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="WarrantsInConnectionWithHerculesCreditFacilityToLendersMember" xlink:title="presentation: ClassOfWarrantOrRightDomain to WarrantsInConnectionWithHerculesCreditFacilityToLendersMember" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_WarrantsInConnectionWith2009ConvertibleNotesMember" xlink:label="WarrantsInConnectionWith2009ConvertibleNotesMember" xlink:title="WarrantsInConnectionWith2009ConvertibleNotesMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="WarrantsInConnectionWith2009ConvertibleNotesMember" xlink:title="presentation: ClassOfWarrantOrRightDomain to WarrantsInConnectionWith2009ConvertibleNotesMember" use="optional" order="8002.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="StatementClassOfStockAxis" xlink:title="StatementClassOfStockAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtInstrumentTable" xlink:to="StatementClassOfStockAxis" xlink:title="presentation: DebtInstrumentTable to StatementClassOfStockAxis" use="optional" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="ClassOfStockDomain" xlink:title="ClassOfStockDomain"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StatementClassOfStockAxis" xlink:to="ClassOfStockDomain" xlink:title="presentation: StatementClassOfStockAxis to ClassOfStockDomain" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockMember" xlink:label="CommonStockMember" xlink:title="CommonStockMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfStockDomain" xlink:to="CommonStockMember" xlink:title="presentation: ClassOfStockDomain to CommonStockMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="DebtDisclosureAbstract" xlink:title="DebtDisclosureAbstract"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DebtDisclosureAbstract" xlink:to="DebtInstrumentTable" xlink:title="presentation: DebtDisclosureAbstract to DebtInstrumentTable" use="optional" order="1.0"/>
</link:presentationLink>
<link:presentationLink xlink:type="extended" xlink:role="http://www.pacira.com/role/DisclosureRelatedPartyTransactionsDetails">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeAxis" xlink:label="RangeAxis" xlink:title="RangeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeMember" xlink:label="RangeMember" xlink:title="RangeMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeAxis" xlink:to="RangeMember" xlink:title="presentation: RangeAxis to RangeMember" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MaximumMember" xlink:label="MaximumMember" xlink:title="MaximumMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeMember" xlink:to="MaximumMember" xlink:title="presentation: RangeMember to MaximumMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="RelatedPartyTransactionsAbstract" xlink:title="RelatedPartyTransactionsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:title="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsAbstract" xlink:to="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:title="presentation: RelatedPartyTransactionsAbstract to ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="RelatedPartyTransactionsByRelatedPartyAxis" xlink:title="RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="RelatedPartyTransactionsByRelatedPartyAxis" xlink:title="presentation: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to RelatedPartyTransactionsByRelatedPartyAxis" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="RelatedPartyDomain" xlink:title="RelatedPartyDomain"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="RelatedPartyDomain" xlink:title="presentation: RelatedPartyTransactionsByRelatedPartyAxis to RelatedPartyDomain" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DirectorMember" xlink:label="DirectorMember" xlink:title="DirectorMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="DirectorMember" xlink:title="presentation: RelatedPartyDomain to DirectorMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_MPMAssetManagementMember" xlink:label="MPMAssetManagementMember" xlink:title="MPMAssetManagementMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="MPMAssetManagementMember" xlink:title="presentation: RelatedPartyDomain to MPMAssetManagementMember" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_StackPharmaceuticalsIncMember" xlink:label="StackPharmaceuticalsIncMember" xlink:title="StackPharmaceuticalsIncMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="StackPharmaceuticalsIncMember" xlink:title="presentation: RelatedPartyDomain to StackPharmaceuticalsIncMember" use="optional" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RhythmPharmaceuticalsIncMember" xlink:label="RhythmPharmaceuticalsIncMember" xlink:title="RhythmPharmaceuticalsIncMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="RhythmPharmaceuticalsIncMember" xlink:title="presentation: RelatedPartyDomain to RhythmPharmaceuticalsIncMember" use="optional" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InvestorMember" xlink:label="InvestorMember" xlink:title="InvestorMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="InvestorMember" xlink:title="presentation: RelatedPartyDomain to InvestorMember" use="optional" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_InvestorsIntoDebtAgreementMember" xlink:label="InvestorsIntoDebtAgreementMember" xlink:title="InvestorsIntoDebtAgreementMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyDomain" xlink:to="InvestorsIntoDebtAgreementMember" xlink:title="presentation: RelatedPartyDomain to InvestorsIntoDebtAgreementMember" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InstrumentAxis" xlink:label="InstrumentAxis" xlink:title="InstrumentAxis"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="InstrumentAxis" xlink:title="presentation: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to InstrumentAxis" use="optional" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InstrumentTypeMember" xlink:label="InstrumentTypeMember" xlink:title="InstrumentTypeMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InstrumentAxis" xlink:to="InstrumentTypeMember" xlink:title="presentation: InstrumentAxis to InstrumentTypeMember" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_ConsultingAgreementMember" xlink:label="ConsultingAgreementMember" xlink:title="ConsultingAgreementMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InstrumentTypeMember" xlink:to="ConsultingAgreementMember" xlink:title="presentation: InstrumentTypeMember to ConsultingAgreementMember" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_AmendedAndRestatedConsultingAgreementMember" xlink:label="AmendedAndRestatedConsultingAgreementMember" xlink:title="AmendedAndRestatedConsultingAgreementMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InstrumentTypeMember" xlink:to="AmendedAndRestatedConsultingAgreementMember" xlink:title="presentation: InstrumentTypeMember to AmendedAndRestatedConsultingAgreementMember" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="RangeAxis" xlink:title="presentation: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to RangeAxis" use="optional" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="RelatedPartyTransactionLineItems" xlink:title="RelatedPartyTransactionLineItems"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="RelatedPartyTransactionLineItems" xlink:title="presentation: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to RelatedPartyTransactionLineItems" use="optional" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionFeePayablePerMonth" xlink:label="RelatedPartyTransactionFeePayablePerMonth" xlink:title="RelatedPartyTransactionFeePayablePerMonth"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionFeePayablePerMonth" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionFeePayablePerMonth" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth" xlink:label="RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth" xlink:title="RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionFeePayablePerYear" xlink:label="RelatedPartyTransactionFeePayablePerYear" xlink:title="RelatedPartyTransactionFeePayablePerYear"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionFeePayablePerYear" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionFeePayablePerYear" use="optional" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" xlink:label="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" xlink:title="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" use="optional" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" xlink:label="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" xlink:title="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" use="optional" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:label="RelatedPartyTransactionAmountsOfTransaction" xlink:title="RelatedPartyTransactionAmountsOfTransaction"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionAmountsOfTransaction" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionAmountsOfTransaction" use="optional" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionNumberOfAmendmentsOfOriginalServicesAgreement" xlink:label="RelatedPartyTransactionNumberOfAmendmentsOfOriginalServicesAgreement" xlink:title="RelatedPartyTransactionNumberOfAmendmentsOfOriginalServicesAgreement"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionNumberOfAmendmentsOfOriginalServicesAgreement" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionNumberOfAmendmentsOfOriginalServicesAgreement" use="optional" order="8004.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionPurchasesFromRelatedParty" xlink:label="RelatedPartyTransactionPurchasesFromRelatedParty" xlink:title="RelatedPartyTransactionPurchasesFromRelatedParty"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionPurchasesFromRelatedParty" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionPurchasesFromRelatedParty" use="optional" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DueToRelatedPartiesCurrentAndNoncurrent" xlink:label="DueToRelatedPartiesCurrentAndNoncurrent" xlink:title="DueToRelatedPartiesCurrentAndNoncurrent"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="DueToRelatedPartiesCurrentAndNoncurrent" xlink:title="presentation: RelatedPartyTransactionLineItems to DueToRelatedPartiesCurrentAndNoncurrent" use="optional" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="RevenueFromRelatedParties" xlink:title="RevenueFromRelatedParties"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RevenueFromRelatedParties" xlink:title="presentation: RelatedPartyTransactionLineItems to RevenueFromRelatedParties" use="optional" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionEligibleBonusUponMeetingTargets" xlink:label="RelatedPartyTransactionEligibleBonusUponMeetingTargets" xlink:title="RelatedPartyTransactionEligibleBonusUponMeetingTargets"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionEligibleBonusUponMeetingTargets" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionEligibleBonusUponMeetingTargets" use="optional" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NotesPayableRelatedPartiesCurrentAndNoncurrent" xlink:label="NotesPayableRelatedPartiesCurrentAndNoncurrent" xlink:title="NotesPayableRelatedPartiesCurrentAndNoncurrent"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="NotesPayableRelatedPartiesCurrentAndNoncurrent" xlink:title="presentation: RelatedPartyTransactionLineItems to NotesPayableRelatedPartiesCurrentAndNoncurrent" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_RelatedPartyTransactionInterestAccruedOnDebt" xlink:label="RelatedPartyTransactionInterestAccruedOnDebt" xlink:title="RelatedPartyTransactionInterestAccruedOnDebt"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionInterestAccruedOnDebt" xlink:title="presentation: RelatedPartyTransactionLineItems to RelatedPartyTransactionInterestAccruedOnDebt" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="DebtConversionOriginalDebtAmount1" xlink:title="DebtConversionOriginalDebtAmount1"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="DebtConversionOriginalDebtAmount1" xlink:title="presentation: RelatedPartyTransactionLineItems to DebtConversionOriginalDebtAmount1" use="optional" order="8002.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="DebtConversionConvertedInstrumentSharesIssued1" xlink:title="DebtConversionConvertedInstrumentSharesIssued1"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionLineItems" xlink:to="DebtConversionConvertedInstrumentSharesIssued1" xlink:title="presentation: RelatedPartyTransactionLineItems to DebtConversionConvertedInstrumentSharesIssued1" use="optional" order="8003.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
</link:presentationLink>
<link:presentationLink xlink:type="extended" xlink:role="http://www.pacira.com/role/DisclosureSummaryOfSignificantAccountingPoliciesDetails">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeAxis" xlink:label="RangeAxis" xlink:title="RangeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RangeMember" xlink:label="RangeMember" xlink:title="RangeMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeAxis" xlink:to="RangeMember" xlink:title="presentation: RangeAxis to RangeMember" use="optional" order="8000.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MaximumMember" xlink:label="MaximumMember" xlink:title="MaximumMember"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RangeMember" xlink:to="MaximumMember" xlink:title="presentation: RangeMember to MaximumMember" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="AccountingPoliciesAbstract" xlink:title="AccountingPoliciesAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevenueRecognitionAbstract" xlink:label="RevenueRecognitionAbstract" xlink:title="RevenueRecognitionAbstract"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="RevenueRecognitionAbstract" xlink:title="presentation: AccountingPoliciesAbstract to RevenueRecognitionAbstract" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_BeginningPeriodPriorToProductExpirationAllowedForReturningProduct" xlink:label="BeginningPeriodPriorToProductExpirationAllowedForReturningProduct" xlink:title="BeginningPeriodPriorToProductExpirationAllowedForReturningProduct"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RevenueRecognitionAbstract" xlink:to="BeginningPeriodPriorToProductExpirationAllowedForReturningProduct" xlink:title="presentation: RevenueRecognitionAbstract to BeginningPeriodPriorToProductExpirationAllowedForReturningProduct" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned" xlink:label="PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned" xlink:title="PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RevenueRecognitionAbstract" xlink:to="PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned" xlink:title="presentation: RevenueRecognitionAbstract to PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_LiquidityAbstract" xlink:label="LiquidityAbstract" xlink:title="LiquidityAbstract"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="LiquidityAbstract" xlink:title="presentation: AccountingPoliciesAbstract to LiquidityAbstract" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:label="ProceedsFromDebtNetOfIssuanceCosts" xlink:title="ProceedsFromDebtNetOfIssuanceCosts"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LiquidityAbstract" xlink:to="ProceedsFromDebtNetOfIssuanceCosts" xlink:title="presentation: LiquidityAbstract to ProceedsFromDebtNetOfIssuanceCosts" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_StockIssuedDuringPeriodExerciseOfOverallotmentOptionByUnderwriters" xlink:label="StockIssuedDuringPeriodExerciseOfOverallotmentOptionByUnderwriters" xlink:title="StockIssuedDuringPeriodExerciseOfOverallotmentOptionByUnderwriters"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LiquidityAbstract" xlink:to="StockIssuedDuringPeriodExerciseOfOverallotmentOptionByUnderwriters" xlink:title="presentation: LiquidityAbstract to StockIssuedDuringPeriodExerciseOfOverallotmentOptionByUnderwriters" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_ProceedsFromIssuanceOfSharesToUnderwriters" xlink:label="ProceedsFromIssuanceOfSharesToUnderwriters" xlink:title="ProceedsFromIssuanceOfSharesToUnderwriters"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LiquidityAbstract" xlink:to="ProceedsFromIssuanceOfSharesToUnderwriters" xlink:title="presentation: LiquidityAbstract to ProceedsFromIssuanceOfSharesToUnderwriters" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_PeriodOfAdequateFundingProvidedByOfferingAndCurrentCashResources" xlink:label="PeriodOfAdequateFundingProvidedByOfferingAndCurrentCashResources" xlink:title="PeriodOfAdequateFundingProvidedByOfferingAndCurrentCashResources"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LiquidityAbstract" xlink:to="PeriodOfAdequateFundingProvidedByOfferingAndCurrentCashResources" xlink:title="presentation: LiquidityAbstract to PeriodOfAdequateFundingProvidedByOfferingAndCurrentCashResources" use="optional" order="8002.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_SummaryOfSignificantAccountingPoliciesTable" xlink:label="SummaryOfSignificantAccountingPoliciesTable" xlink:title="SummaryOfSignificantAccountingPoliciesTable"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="SummaryOfSignificantAccountingPoliciesTable" xlink:title="presentation: AccountingPoliciesAbstract to SummaryOfSignificantAccountingPoliciesTable" use="optional" order="8001.0"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="SummaryOfSignificantAccountingPoliciesTable" xlink:to="RangeAxis" xlink:title="presentation: SummaryOfSignificantAccountingPoliciesTable to RangeAxis" use="optional" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="SummaryOfSignificantAccountingPoliciesLineItems" xlink:title="SummaryOfSignificantAccountingPoliciesLineItems"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="SummaryOfSignificantAccountingPoliciesTable" xlink:to="SummaryOfSignificantAccountingPoliciesLineItems" xlink:title="presentation: SummaryOfSignificantAccountingPoliciesTable to SummaryOfSignificantAccountingPoliciesLineItems" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_ReclassificationAbstract" xlink:label="ReclassificationAbstract" xlink:title="ReclassificationAbstract"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="SummaryOfSignificantAccountingPoliciesLineItems" xlink:to="ReclassificationAbstract" xlink:title="presentation: SummaryOfSignificantAccountingPoliciesLineItems to ReclassificationAbstract" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PriorPeriodReclassificationAdjustment" xlink:label="PriorPeriodReclassificationAdjustment" xlink:title="PriorPeriodReclassificationAdjustment"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ReclassificationAbstract" xlink:to="PriorPeriodReclassificationAdjustment" xlink:title="presentation: ReclassificationAbstract to PriorPeriodReclassificationAdjustment" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_ChangesInCapitalStructureAbstract" xlink:label="ChangesInCapitalStructureAbstract" xlink:title="ChangesInCapitalStructureAbstract"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="ChangesInCapitalStructureAbstract" xlink:title="presentation: AccountingPoliciesAbstract to ChangesInCapitalStructureAbstract" use="optional" order="8002.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_CommonStockReverseStockSplitConversionRatio" xlink:label="CommonStockReverseStockSplitConversionRatio" xlink:title="CommonStockReverseStockSplitConversionRatio"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ChangesInCapitalStructureAbstract" xlink:to="CommonStockReverseStockSplitConversionRatio" xlink:title="presentation: ChangesInCapitalStructureAbstract to CommonStockReverseStockSplitConversionRatio" use="optional" order="8000.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_MaximumPeriodForCashPaymentForFractionalSharesOnReverseStockSplitConversion" xlink:label="MaximumPeriodForCashPaymentForFractionalSharesOnReverseStockSplitConversion" xlink:title="MaximumPeriodForCashPaymentForFractionalSharesOnReverseStockSplitConversion"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ChangesInCapitalStructureAbstract" xlink:to="MaximumPeriodForCashPaymentForFractionalSharesOnReverseStockSplitConversion" xlink:title="presentation: ChangesInCapitalStructureAbstract to MaximumPeriodForCashPaymentForFractionalSharesOnReverseStockSplitConversion" use="optional" order="8001.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
</link:presentationLink>
<link:presentationLink xlink:type="extended" xlink:role="http://www.pacira.com/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="AccountingPoliciesAbstract" xlink:title="AccountingPoliciesAbstract"/>
<link:loc xlink:type="locator" xlink:href="pcrx-20121231.xsd#pcrx_BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock" xlink:label="BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock" xlink:title="BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock" use="optional" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="UseOfEstimates" xlink:title="UseOfEstimates"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="UseOfEstimates" xlink:title="presentation: AccountingPoliciesAbstract to UseOfEstimates" use="optional" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiquidityDisclosureTextBlock" xlink:label="LiquidityDisclosureTextBlock" xlink:title="LiquidityDisclosureTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="LiquidityDisclosureTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to LiquidityDisclosureTextBlock" use="optional" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="RevenueRecognitionPolicyTextBlock" xlink:title="RevenueRecognitionPolicyTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="RevenueRecognitionPolicyTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to RevenueRecognitionPolicyTextBlock" use="optional" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorCustomersPolicyPolicyTextBlock" xlink:label="MajorCustomersPolicyPolicyTextBlock" xlink:title="MajorCustomersPolicyPolicyTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="MajorCustomersPolicyPolicyTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to MajorCustomersPolicyPolicyTextBlock" use="optional" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="ResearchAndDevelopmentExpensePolicy" xlink:title="ResearchAndDevelopmentExpensePolicy"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="ResearchAndDevelopmentExpensePolicy" xlink:title="presentation: AccountingPoliciesAbstract to ResearchAndDevelopmentExpensePolicy" use="optional" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="CashAndCashEquivalentsPolicyTextBlock" xlink:title="CashAndCashEquivalentsPolicyTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="CashAndCashEquivalentsPolicyTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to CashAndCashEquivalentsPolicyTextBlock" use="optional" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:label="CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:title="CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:title="presentation: AccountingPoliciesAbstract to CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" use="optional" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MarketableSecuritiesPolicy" xlink:label="MarketableSecuritiesPolicy" xlink:title="MarketableSecuritiesPolicy"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="MarketableSecuritiesPolicy" xlink:title="presentation: AccountingPoliciesAbstract to MarketableSecuritiesPolicy" use="optional" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="InventoryPolicyTextBlock" xlink:title="InventoryPolicyTextBlock"/>
<link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesAbstract" xlink:to="InventoryPolicyTextBlock" xlink:title="presentation: AccountingPoliciesAbstract to InventoryPolicyTextBlock" use="optional" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
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2 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

12/13/13  SEC                               UPLOAD9/20/17    1:34K  Pacira BioSciences, Inc.
12/02/13  SEC                               UPLOAD9/20/17    1:153K Pacira BioSciences, Inc.
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Filing Submission 0001047469-13-002336   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
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