SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-Q’ for 3/31/16 – ‘EX-101.LAB’

On:  Monday, 5/9/16, at 4:27pm ET   ·   For:  3/31/16   ·   Accession #:  944809-16-22   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 11/9/15 for 9/30/15   ·   Next:  ‘10-Q’ on 8/8/16 for 6/30/16   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 5/09/16  Opko Health, Inc.                 10-Q        3/31/16   77:8.6M

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    593K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     29K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     29K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     23K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     23K 
12: R1          Document and Entity Information                     HTML     41K 
13: R2          Condensed Consolidated Balance Sheets (Unaudited)   HTML    105K 
14: R3          Condensed Consolidated Balance Sheets (Unaudited)   HTML     31K 
                (Parenthetical)                                                  
15: R4          Condensed Consolidated Statements of Operations     HTML     91K 
                (Unaudited)                                                      
16: R5          Condensed Consolidated Statements of Comprehensive  HTML     44K 
                Loss (Unaudited)                                                 
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    134K 
                (Unaudited)                                                      
18: R7          Condensed Consolidated Statements of Cash Flows     HTML     25K 
                (Unaudited) (Parenthetical)                                      
19: R8          Business and Organization                           HTML     33K 
20: R9          Summary of Significant Accounting Policies          HTML     76K 
21: R10         Earnings (Loss) Per Share                           HTML     29K 
22: R11         Composition of Certain Financial Statement          HTML    130K 
                Captions                                                         
23: R12         Acquisitions, Investments and Licenses              HTML    116K 
24: R13         Debt                                                HTML    131K 
25: R14         Accumulated Other Comprehensive Income (Loss)       HTML     38K 
26: R15         Fair Value Measurements                             HTML    145K 
27: R16         Derivative Contracts                                HTML     53K 
28: R17         Related Party Transactions                          HTML     32K 
29: R18         Commitments and Contingencies                       HTML     36K 
30: R19         Strategic Alliances                                 HTML     43K 
31: R20         Segments                                            HTML    104K 
32: R21         Subsequent Events                                   HTML     34K 
33: R22         Summary of Significant Accounting Policies          HTML    132K 
                (Policies)                                                       
34: R23         Composition of Certain Financial Statement          HTML    131K 
                Captions (Tables)                                                
35: R24         Acquisitions, Investments and Licenses (Tables)     HTML     90K 
36: R25         Debt (Tables)                                       HTML    114K 
37: R26         Accumulated Other Comprehensive Income (Loss)       HTML     35K 
                (Tables)                                                         
38: R27         Fair Value Measurements (Tables)                    HTML    143K 
39: R28         Derivative Contracts (Tables)                       HTML     48K 
40: R29         Segments (Tables)                                   HTML     97K 
41: R30         Business and Organization (Details)                 HTML     48K 
42: R31         Summary of Significant Accounting Policies          HTML     97K 
                (Details)                                                        
43: R32         Earnings (Loss) Per Share (Details)                 HTML     34K 
44: R33         Composition of Certain Financial Statement          HTML    143K 
                Captions (Details)                                               
45: R34         Composition of Certain Financial Statement          HTML     61K 
                Captions - Changes in Goodwill (Details)                         
46: R35         Acquisitions, Investments and Licenses -            HTML     78K 
                Acquisition Narrative (Details)                                  
47: R36         Acquisitions, Investments and Licenses -            HTML     84K 
                Bio-Reference Purchase Price Allocation (Details)                
48: R37         Acquisitions, Investments and Licenses - Schedule   HTML     32K 
                of Pro Forma (Details)                                           
49: R38         Acquisitions, Investments and Licenses - EirGen     HTML     63K 
                Purchase Price Allocation (Details)                              
50: R39         Acquisitions, Investments and Licenses - Summary    HTML     36K 
                of Investments (Details)                                         
51: R40         Acquisitions, Investments and Licenses - Equity     HTML     52K 
                Method Investments Narrative (Details)                           
52: R41         Acquisitions, Investments and Licenses - Available  HTML     47K 
                for Sale Investments, Sale of Investments and                    
                Warrants and Options Narrative (Details)                         
53: R42         Acquisitions, Investments and Licenses - Variable   HTML     60K 
                Interest Entities Narrative (Details)                            
54: R43         Acquisitions, Investments and Licenses - Other      HTML     49K 
                Narrative (Details)                                              
55: R44         Debt - Narrative (Details)                          HTML    144K 
56: R45         Debt - Notes (Details)                              HTML     58K 
57: R46         Debt - Inputs Used In Lattice Model (Details)       HTML     41K 
58: R47         Debt - Fair Value Of Embedded Derivatives           HTML     29K 
                (Details)                                                        
59: R48         Debt - Lines Of Credit (Details)                    HTML     60K 
60: R49         Debt - Mortgage Notes And Other Debt (Details)      HTML     32K 
61: R50         Accumulated Other Comprehensive Income (Loss)       HTML     37K 
                (Details)                                                        
62: R51         Fair Value Measurements - Summary Of Investments    HTML     36K 
                (Details)                                                        
63: R52         Fair Value Measurements - Assets And Liabilities    HTML     60K 
                Measured At Fair Value (Details)                                 
64: R53         Fair Value Measurements - Notes (Details)           HTML     29K 
65: R54         Fair Value Measurements - Level 3 Reconciliation    HTML     38K 
                (Details)                                                        
66: R55         Fair Value Measurements - Narrative (Details)       HTML     34K 
67: R56         Derivative Contracts - Balance Sheet Component      HTML     40K 
                (Details)                                                        
68: R57         Derivative Contracts - Derivative Gains (Losses)    HTML     32K 
                (Details)                                                        
69: R58         Related Party Transactions (Details)                HTML    111K 
70: R59         Commitments and Contingencies (Details)             HTML     37K 
71: R60         Strategic Alliances (Details)                       HTML     96K 
72: R61         Segments - Narrative (Details)                      HTML     42K 
73: R62         Segments - Operations and Assets Information        HTML     74K 
                (Details)                                                        
74: R63         Subsequent Events (Details)                         HTML     63K 
76: XML         IDEA XML File -- Filing Summary                      XML    136K 
75: EXCEL       IDEA Workbook of Financial Reports                  XLSX    108K 
 6: EX-101.INS  XBRL Instance -- opk-20160331                        XML   2.50M 
 8: EX-101.CAL  XBRL Calculations -- opk-20160331_cal                XML    234K 
 9: EX-101.DEF  XBRL Definitions -- opk-20160331_def                 XML   1.06M 
10: EX-101.LAB  XBRL Labels -- opk-20160331_lab                      XML   2.02M 
11: EX-101.PRE  XBRL Presentations -- opk-20160331_pre               XML   1.28M 
 7: EX-101.SCH  XBRL Schema -- opk-20160331                          XSD    190K 
77: ZIP         XBRL Zipped Folder -- 0000944809-16-000022-xbrl      Zip    296K

‘EX-101.LAB’   —   XBRL Labels — opk-20160331_lab

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple"/>
<link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
<link:label id="lab_us-gaap_BusinessCombinationsAbstract_EE8DECA678D736829D285F87948F302A_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsAbstract_EE8DECA678D736829D285F87948F302A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_EE8DECA678D736829D285F87948F302A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_EE8DECA678D736829D285F87948F302A" xlink:to="lab_us-gaap_BusinessCombinationsAbstract_EE8DECA678D736829D285F87948F302A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F_label_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F" xlink:to="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_802CE93E1F16A9027CBE5F87948FC82F" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF" xlink:to="lab_us-gaap_BusinessAcquisitionAxis_8CC5937C8C628BEE10F35F87949091EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80" xlink:to="lab_us-gaap_BusinessAcquisitionAcquireeDomain_511C33E71F5AAC3A6DB45F8794907B80" xlink:type="arc"/>
<link:label id="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8_terseLabel_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> VBIV </link:label>
<link:label id="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8_label_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> VBI Vaccines Inc [Member] </link:label>
<link:label id="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8_documentation_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> VBI Vaccines Inc [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_VBIVaccinesIncMember" xlink:label="loc_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:to="lab_opk_VBIVaccinesIncMember_964391CFFC21E5FCE1985F87949053A8" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Axis] </link:label>
<link:label id="lab_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF" xlink:to="lab_us-gaap_IncomeStatementLocationAxis_A2CAFB27B7AE1BF2BDEA5F87949057EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:label id="lab_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3" xlink:to="lab_us-gaap_IncomeStatementLocationDomain_B9E2329234164D9B413A5F8794907AD3" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D_terseLabel_en-US" xlink:label="lab_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Income (Expense) </link:label>
<link:label id="lab_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D_label_en-US" xlink:label="lab_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Operating Income (Expense) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherOperatingIncomeExpenseMember" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D" xlink:to="lab_us-gaap_OtherOperatingIncomeExpenseMember_FD720770ECAE6FEC7A875F879490D20D" xlink:type="arc"/>
<link:label id="lab_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E_terseLabel_en-US" xlink:label="lab_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Legal Entity [Axis] </link:label>
<link:label id="lab_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E_label_en-US" xlink:label="lab_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Legal Entity [Axis] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E" xlink:to="lab_dei_LegalEntityAxis_5D00D94FFEFBE2D2FA345F879490063E" xlink:type="arc"/>
<link:label id="lab_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45_terseLabel_en-US" xlink:label="lab_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity [Domain] </link:label>
<link:label id="lab_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45_label_en-US" xlink:label="lab_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity [Domain] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45" xlink:to="lab_dei_EntityDomain_CE5F13A9ECF3D6B494785F879490AD45" xlink:type="arc"/>
<link:label id="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC_terseLabel_en-US" xlink:label="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> SciVac </link:label>
<link:label id="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC_label_en-US" xlink:label="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SciVac [Member] </link:label>
<link:label id="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC_documentation_en-US" xlink:label="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> SciVac [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:to="lab_opk_SciVacMember_3E5B31DE83885C95D7475F8794904EDC" xlink:type="arc"/>
<link:label id="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762_terseLabel_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> STI </link:label>
<link:label id="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762_label_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Levon Resources Ltd [Member] </link:label>
<link:label id="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762_documentation_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Levon Resources Ltd [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LevonResourcesLtdMember" xlink:label="loc_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:to="lab_opk_LevonResourcesLtdMember_EB40EA089F9AED6FAFA15F8794900762" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entities [Axis] </link:label>
<link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1" xlink:to="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_88B47220A2190E9499185F87949050F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058_terseLabel_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Classification [Domain] </link:label>
<link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058_label_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Classification [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058" xlink:to="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_E85A0178B6A3B115644A5F879490D058" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Primary Beneficiary </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Primary Beneficiary [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD" xlink:to="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_944A848F9DBD10BAB5F55F879490D5FD" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F_label_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F" xlink:to="lab_us-gaap_StatementClassOfStockAxis_5CCC82D94741A9EF21C75F8794902F6F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:label id="lab_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B" xlink:to="lab_us-gaap_ClassOfStockDomain_58B5E106D14053E3DF625F879490B26B" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series A Preferred Stock </link:label>
<link:label id="lab_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128_label_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Series A Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128" xlink:to="lab_us-gaap_SeriesAPreferredStockMember_70A00F512CE49676844F5F8794908128" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restricted Stock </link:label>
<link:label id="lab_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0_label_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restricted Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0" xlink:to="lab_us-gaap_RestrictedStockMember_A0F1AB4C3395D3746E7B5F87949129C0" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment, Name [Axis] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_EFAB5FFA707C7F5A8BF35F8794918228" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment, Name [Domain] </link:label>
<link:label id="lab_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163" xlink:to="lab_us-gaap_EquityMethodInvesteeNameDomain_39AB6E471B7D159BE79B5F8794919163" xlink:type="arc"/>
<link:label id="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D_terseLabel_en-US" xlink:label="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Zebra </link:label>
<link:label id="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D_label_en-US" xlink:label="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:label id="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D_documentation_en-US" xlink:label="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ZebraMember" xlink:label="loc_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:to="lab_opk_ZebraMember_5B7308A308A17C2CE8135F879491C26D" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8" xlink:to="lab_us-gaap_VariableInterestEntityLineItems_47246F5A807F7546FA1A5F8794914DF8" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment owned, shares </link:label>
<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834_label_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment Owned, Balance, Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentOwnedBalanceShares" xlink:label="loc_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834" xlink:to="lab_us-gaap_InvestmentOwnedBalanceShares_01ECF9A12FEFD5B1AB665F879491F834" xlink:type="arc"/>
<link:label id="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D_terseLabel_en-US" xlink:label="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares received as a gift </link:label>
<link:label id="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D_label_en-US" xlink:label="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Received As Gift </link:label>
<link:label id="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D_documentation_en-US" xlink:label="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares Received As Gift </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SharesReceivedAsGift" xlink:label="loc_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:to="lab_opk_SharesReceivedAsGift_07525C07084CFB4511EE5F879491119D" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_150BDB92A46AC1A3091C5F8794915B97" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock ownership percentage </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="loc_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F" xlink:to="lab_us-gaap_VariableInterestEntityOwnershipPercentage_651461217E586BE5CDE45F8794910C1F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14_terseLabel_en-US" xlink:label="lab_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional working capital </link:label>
<link:label id="lab_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14_label_en-US" xlink:label="lab_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Due from Affiliates </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DueFromAffiliates" xlink:label="loc_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14" xlink:to="lab_us-gaap_DueFromAffiliates_2ED4B89A66B1F3E6F8CA5F8794912B14" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605_terseLabel_en-US" xlink:label="lab_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain on deconsolidation of SciVac </link:label>
<link:label id="lab_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605_label_en-US" xlink:label="lab_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deconsolidation, Gain (Loss), Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeconsolidationGainOrLossAmount" xlink:label="loc_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605" xlink:to="lab_us-gaap_DeconsolidationGainOrLossAmount_07E263A344A6BF3BAFDB5F879491E605" xlink:type="arc"/>
<link:label id="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D_terseLabel_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash contribution </link:label>
<link:label id="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D_label_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Cash Contribution </link:label>
<link:label id="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D_documentation_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Cash Contribution </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_VariableInterestEntityCashContribution" xlink:label="loc_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:to="lab_opk_VariableInterestEntityCashContribution_624BB29F765B982F947D5F879491C06D" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Exchange ratio </link:label>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56_label_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Exchange Ratio </link:label>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Exchange Ratio </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio" xlink:label="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:to="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_70BF51629AA5021A48EF5F8794918B56" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of diluted shares outstanding </link:label>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27_label_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Percentage of Diluted Shares Outstanding </link:label>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Percentage of Diluted Shares Outstanding </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding" xlink:label="loc_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:to="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_C8D47F8BC136476943745F879491BF27" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosuresAbstract_37C4471E3FB235F4837B5F8794D1D68B_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract_37C4471E3FB235F4837B5F8794D1D68B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_37C4471E3FB235F4837B5F8794D1D68B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_37C4471E3FB235F4837B5F8794D1D68B" xlink:to="lab_us-gaap_FairValueDisclosuresAbstract_37C4471E3FB235F4837B5F8794D1D68B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> FAIR VALUE MEASUREMENTS </link:label>
<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07" xlink:to="lab_us-gaap_FairValueDisclosuresTextBlock_564C6701B4F625A146755F8794D19B07" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_FDEC8B2D581414139A778D93490630A2" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis_855E786AA45A1468407E8D9349079A00" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_35484D5DD7C27FB9A0738D934907461C" xlink:type="arc"/>
<link:label id="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB_terseLabel_en-US" xlink:label="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB_label_en-US" xlink:label="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration [Member] </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB_documentation_en-US" xlink:label="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Contingent consideration. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ContingentConsiderationMember" xlink:label="loc_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:to="lab_opk_ContingentConsiderationMember_82F8B7E086669E921F1A8D9349070DFB" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65_verboseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative Financial Instruments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65" xlink:to="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_8D648B4E3B728A475B228D934907AD65" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> [Line Items] for Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_33E6063501429A5CCDDD8D934907E778" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_FF584EB116819A6F9B4C8D934907AFEE" xlink:type="arc"/>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96_terseLabel_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total losses for the period: </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96_label_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) [Abstract] </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96_documentation_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) [Abstract] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:to="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_07479DCB99FFA7C107678D934907AE96" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200_periodStartLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning Balance </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7163EEBCD6C3862E05B78D9349078200" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78_negatedLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Included in results of operations </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_94139810D88B9A2833328D9349078B78" xlink:type="arc"/>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966_negatedTerseLabel_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency impact </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966_label_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966_documentation_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:to="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_6DFFAD811A36FADA47998D934907F966" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Payments </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_90B5AA9C7D61591378E08D934907BA36" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448_negatedLabel_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Conversion </link:label>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448_label_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Embedded Derivative, Amount </link:label>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448_documentation_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Embedded Derivative, Amount </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtConversionEmbeddedDerivativeAmount" xlink:label="loc_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:to="lab_opk_DebtConversionEmbeddedDerivativeAmount_0330A0BB4224228B49EE8D9349075448" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_C8077CB200DF4D58CA8C8D9349076F08_periodEndLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_C8077CB200DF4D58CA8C8D9349076F08" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending Balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_C8077CB200DF4D58CA8C8D9349076F08" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_C8077CB200DF4D58CA8C8D9349076F08" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_C8077CB200DF4D58CA8C8D9349076F08" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD7735D7D6CBE23BB34F5F879590565D" xlink:type="arc"/>
<link:label id="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1_terseLabel_en-US" xlink:label="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Bio Reference </link:label>
<link:label id="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1_label_en-US" xlink:label="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bio-Reference [Member] </link:label>
<link:label id="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1_documentation_en-US" xlink:label="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bio-Reference [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BioReferenceMember" xlink:label="loc_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:to="lab_opk_BioReferenceMember_0381A4AA8672FBC0AFA35F8795909FF1" xlink:type="arc"/>
<link:label id="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE_verboseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> EirGen </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE_documentation_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EirGenPharmaLimitedMember" xlink:label="loc_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:to="lab_opk_EirGenPharmaLimitedMember_5D61C42B027CF5838A835F879590A6FE" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Line Items] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA" xlink:to="lab_us-gaap_BusinessAcquisitionLineItems_BDA8A095618B536428BC5F879590C3CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Purchase Price Allocation </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_B4F232B0F2F7110759FA5F8795903E95" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pro Forma Results </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Information [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A" xlink:to="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_2067450423C7E64B874B5F879590620A" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E_verboseLabel_en-US" xlink:label="lab_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounting Method, Carrying Value and Underlying Equity in Net Assets of Unconsolidated Investments </link:label>
<link:label id="lab_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E_label_en-US" xlink:label="lab_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentTableTextBlock" xlink:label="loc_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E" xlink:to="lab_invest_InvestmentTableTextBlock_85214CC6301E166AE71B5F879590BC2E" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsAbstract_A1D1E36B2E43233F38A85F87953C4360_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsAbstract_A1D1E36B2E43233F38A85F87953C4360" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transactions [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_A1D1E36B2E43233F38A85F87953C4360" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_A1D1E36B2E43233F38A85F87953C4360" xlink:to="lab_us-gaap_RelatedPartyTransactionsAbstract_A1D1E36B2E43233F38A85F87953C4360" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0_verboseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> RELATED PARTY TRANSACTIONS </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transactions Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0" xlink:to="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_B5D297BB598116119D255F87953CE1E0" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_E99A9EE7EBEEA63652975F87951836D3_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract_E99A9EE7EBEEA63652975F87951836D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Financial Position [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_E99A9EE7EBEEA63652975F87951836D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_E99A9EE7EBEEA63652975F87951836D3" xlink:to="lab_us-gaap_StatementOfFinancialPositionAbstract_E99A9EE7EBEEA63652975F87951836D3" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, par value (in dollars per share) </link:label>
<link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B_label_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Par or Stated Value Per Share </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B" xlink:to="lab_us-gaap_CommonStockParOrStatedValuePerShare_72BEFB4FD2CAF591301B5F879518342B" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares authorized (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares Authorized </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9" xlink:to="lab_us-gaap_CommonStockSharesAuthorized_330E078F55FB98F2E7045F8795189BA9" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares issued (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5" xlink:to="lab_us-gaap_CommonStockSharesIssued_8A3937D31CCF2CBE65E35F879518B9C5" xlink:type="arc"/>
<link:label id="lab_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604_verboseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Treasury stock, shares (in shares) </link:label>
<link:label id="lab_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604_label_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock, Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604" xlink:to="lab_us-gaap_TreasuryStockShares_28EB08620F8309EB0D5F5F8795184604" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtDisclosureAbstract_FC0057A9D756A4602F8B87E7E8EB1995_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureAbstract_FC0057A9D756A4602F8B87E7E8EB1995" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_FC0057A9D756A4602F8B87E7E8EB1995" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureAbstract_FC0057A9D756A4602F8B87E7E8EB1995" xlink:to="lab_us-gaap_DebtDisclosureAbstract_FC0057A9D756A4602F8B87E7E8EB1995" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB" xlink:to="lab_us-gaap_DebtInstrumentTable_7F12239F17A26B4B65A487E7E8EB40BB" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716" xlink:to="lab_us-gaap_LongtermDebtTypeAxis_C64436443BC3E640B62C87E7E8EBD716" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498" xlink:to="lab_us-gaap_LongtermDebtTypeDomain_2FFCA123D079DA55009E87E7E8EB0498" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes </link:label>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B_label_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B" xlink:to="lab_us-gaap_ConvertibleNotesPayableMember_6770F85FFACAD1B4A2AC87E7E8EBA00B" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39" xlink:to="lab_us-gaap_DebtInstrumentLineItems_4BC04F9047661F4E0A8E87E7E8EB2E39" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356_label_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356_documentation_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtInstrumentRollForward" xlink:label="loc_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:to="lab_opk_DebtInstrumentRollForward_6E7C06FCE1092061700187E7E8EBE356" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607_periodStartLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, beginning balance </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Fair Value of Embedded Derivative Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_56E1F293CFA4D0A08CC087E7E8EB6607" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923_periodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_E6233201C7084E48306587E7E8EB5923" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US"> Discount, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Unamortized Discount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_D518B975C73524127F5887E7E8EB18E9" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US"> Debt issuance cost, beginning balance </link:label>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06_label_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Issuance Costs, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredFinanceCostsNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06" xlink:to="lab_us-gaap_DeferredFinanceCostsNet_DAEBFD33011C796616F687E7E8EC7E06" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6_periodStartLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Total, beginning balance </link:label>
<link:label id="lab_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6_label_en-US" xlink:label="lab_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6" xlink:to="lab_us-gaap_LongTermDebt_FED285C35C060DAF67A887E7E8EC81C6" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt discount </link:label>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC_label_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Discount (Premium) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC" xlink:to="lab_us-gaap_AmortizationOfDebtDiscountPremium_18EC8AF95BBFA23359F387E7E8ECD5FC" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt issuance costs </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Issuance Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_8485929752B25999DE3E87E7E8ECCC5C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt discount and debt issuance costs </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Issuance Costs and Discounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A" xlink:to="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_B50829E259CE06EAFB2487E7E8EC1D7A" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66_verboseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of embedded derivative </link:label>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66_label_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Derivative Instruments, Net, Pretax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EB4DA6D4A0B4432BED7C87E7E8EC0F66" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_4AF71862C432203FB77987E7E8ECEFCE_negatedTerseLabel_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_4AF71862C432203FB77987E7E8ECEFCE" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, conversion </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtConversionEmbeddedDerivativeAmount" xlink:label="loc_opk_DebtConversionEmbeddedDerivativeAmount_4AF71862C432203FB77987E7E8ECEFCE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionEmbeddedDerivativeAmount_4AF71862C432203FB77987E7E8ECEFCE" xlink:to="lab_opk_DebtConversionEmbeddedDerivativeAmount_4AF71862C432203FB77987E7E8ECEFCE" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Convertible notes, conversion </link:label>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20_label_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Original Debt, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="loc_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20" xlink:to="lab_us-gaap_DebtConversionOriginalDebtAmount1_9658C0AB8B7EF023A20887E7E8EC9A20" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6_terseLabel_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discount, conversion </link:label>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6_label_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Debt Discount, Amount </link:label>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6_documentation_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Debt Discount, Amount </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtConversionDebtDiscountAmount" xlink:label="loc_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:to="lab_opk_DebtConversionDebtDiscountAmount_0FE4DBB671229383B42C87E7E8ECD3A6" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E_negatedTerseLabel_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Conversion </link:label>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E_label_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Long-term Debt, Amount </link:label>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E_documentation_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Long-term Debt, Amount </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtConversionLongtermDebtAmount" xlink:label="loc_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:to="lab_opk_DebtConversionLongtermDebtAmount_9B6E661E841CDB74F78487E7E8EC245E" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A5DB8D5BCC864144A98287E7E8EC53AB_periodEndLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A5DB8D5BCC864144A98287E7E8EC53AB" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A5DB8D5BCC864144A98287E7E8EC53AB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A5DB8D5BCC864144A98287E7E8EC53AB" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A5DB8D5BCC864144A98287E7E8EC53AB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_1042585E3AC323B78E9187E7E8EC9B10_periodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_1042585E3AC323B78E9187E7E8EC9B10" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_1042585E3AC323B78E9187E7E8EC9B10" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1042585E3AC323B78E9187E7E8EC9B10" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_1042585E3AC323B78E9187E7E8EC9B10" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_A6C8A997D40186F39AFF87E7E8EC2B37_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_A6C8A997D40186F39AFF87E7E8EC2B37" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US"> Discount, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_A6C8A997D40186F39AFF87E7E8EC2B37" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_A6C8A997D40186F39AFF87E7E8EC2B37" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_A6C8A997D40186F39AFF87E7E8EC2B37" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_40F2855D8968B967468E87E7E8EC2309_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_40F2855D8968B967468E87E7E8EC2309" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US"> Debt issuance cost, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredFinanceCostsNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_40F2855D8968B967468E87E7E8EC2309" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFinanceCostsNet_40F2855D8968B967468E87E7E8EC2309" xlink:to="lab_us-gaap_DeferredFinanceCostsNet_40F2855D8968B967468E87E7E8EC2309" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_24FE6D3212E8F8BAEB6087E7E8EC91B5_periodEndLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_24FE6D3212E8F8BAEB6087E7E8EC91B5" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Total, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_24FE6D3212E8F8BAEB6087E7E8EC91B5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_24FE6D3212E8F8BAEB6087E7E8EC91B5" xlink:to="lab_us-gaap_LongTermDebt_24FE6D3212E8F8BAEB6087E7E8EC91B5" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E1FC9837EFFA53ACA9BC5F8794DCDA4F" xlink:type="arc"/>
<link:label id="lab_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Axis] </link:label>
<link:label id="lab_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4" xlink:to="lab_us-gaap_BalanceSheetLocationAxis_4863CCBD18FF39832E4A5F8794DC69F4" xlink:type="arc"/>
<link:label id="lab_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:label id="lab_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4" xlink:to="lab_us-gaap_BalanceSheetLocationDomain_CA0D101F699793AA3A505F8794DCC2F4" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued Expenses </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6" xlink:to="lab_us-gaap_AccruedLiabilitiesMember_A63A32EC2EB3813D3B055F8794DCA9D6" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606_terseLabel_en-US" xlink:label="lab_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Noncurrent Liabilities </link:label>
<link:label id="lab_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606_label_en-US" xlink:label="lab_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Noncurrent Liabilities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606" xlink:to="lab_us-gaap_OtherNoncurrentLiabilitiesMember_30FED9D470BF5C13EAD45F8794DCF606" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_79E8C90DDA64E9B082975F8794DCCBCB" xlink:type="arc"/>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B_negatedTerseLabel_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of decrease in future sales </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B_label_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Percentage Of Increase Decrease In Future Sales </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B_documentation_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Percentage of increase decrease in future sales. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PercentageOfIncreaseDecreaseInFutureSales" xlink:label="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:to="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_38E17F491798A6FFD03E5F8794DC7F8B" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04_negatedLabel_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Decrease of estimated future sales in amount </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04_label_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination Contingent Consideration Arrangements Change In Amount Of Contingent Consideration If Estimated Future Sales Decrease Ten Percent </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04_documentation_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business combination contingent consideration arrangements change in amount of contingent consideration if estimated future sales decrease ten percent. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:to="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_121EE0664B08C5790E7B5F8794DC6C04" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_2513CF41101606A576675F8794DC85EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets by Major Class [Axis] </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets by Major Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_78127B0245A3CCA75CC35F879562449C" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6537DD7DBA023C48B8E05F8795628F83" xlink:type="arc"/>
<link:label id="lab_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE_terseLabel_en-US" xlink:label="lab_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Trade names </link:label>
<link:label id="lab_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE_label_en-US" xlink:label="lab_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Trade Names [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TradeNamesMember" xlink:label="loc_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE" xlink:to="lab_us-gaap_TradeNamesMember_80C0A604ABA45B6BDB905F87956282DE" xlink:type="arc"/>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E_verboseLabel_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Customer relationships </link:label>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E_label_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Relationships [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E" xlink:to="lab_us-gaap_CustomerRelationshipsMember_86315CC1CB7BF9C403675F879562870E" xlink:type="arc"/>
<link:label id="lab_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C_terseLabel_en-US" xlink:label="lab_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Technology </link:label>
<link:label id="lab_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C_label_en-US" xlink:label="lab_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Technology Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TechnologyEquipmentMember" xlink:label="loc_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C" xlink:to="lab_us-gaap_TechnologyEquipmentMember_D7EADDE4DAD8C2255DA95F879562254C" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Value of OPKO Common Stock issued to Bio-Reference shareholders </link:label>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred, Equity Interests Issued and Issuable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2" xlink:to="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_8A39DEF0FF628B5027AB5F879563E1D2" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Value of replacement stock options awards to holders of Bio-Reference stock options </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Value Assigned </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_CF9AFB4901E0F4EF25335F8795634D3E" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash paid at closing date </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Businesses, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesGross_DF3CD38CCDF3045AE7185F87956307BF" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_E6791FF5E9DCCA48B21A5F879563E4C4" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Receivables </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_53169DC18B228C18E3AA5F8795634E28" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inventory </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_57CD0183679685EF43AE5F879563AFFB" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other current assets, principally deferred tax assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Other </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_13295F3CB1ED7EFCC4A25F87956371DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F_totalLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_FC763D1CCA0DA865749C5F879563985F" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_DDEBDAAACC3872BF69D45F8795636FCF" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A31C72041254EE38F23D5F879563173B" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96_terseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:label id="lab_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96_label_en-US" xlink:label="lab_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96" xlink:to="lab_us-gaap_Goodwill_98072C01BEE228BCAF1C5F879564CB96" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Investments </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Investments </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_5E430E4F4E408EEFBAE55F879564B1AE" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Noncurrent Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_3A05BA548DC925D464215F8795642930" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109_totalLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_0A587B6F05BDB9D275DF5F879564E109" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable and accrued expenses </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_C217673652684D9108B85F879564DB8C" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D_negatedTerseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes payable </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Income Taxes Payable </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Income Taxes Payable </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_7F9464A20E586B4A75195F8795641F3D" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Lines of credit and notes payable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_E1D6C5AD5803C0297A3B5F879564FFAB" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Capital lease obligations </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Capital Lease Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_31939CDFE9DB10F578B05F8795640FEE" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48_negatedLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liability (non-current) </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_E4B7434E88B073CE58F75F8795643A48" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72_totalLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total purchase price </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EE0A7C7C47C5A3D8B0525F8795640B72" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C7B650E63F95BA097E748750B50ECA88_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C7B650E63F95BA097E748750B50ECA88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Commitments and Contingencies Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C7B650E63F95BA097E748750B50ECA88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C7B650E63F95BA097E748750B50ECA88" xlink:to="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C7B650E63F95BA097E748750B50ECA88" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_952F8947902B5412D12B8750B50E5C26" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_B8D95D939C8E71197E278750B50FBD77_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_B8D95D939C8E71197E278750B50FBD77" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_B8D95D939C8E71197E278750B50FBD77" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesMember_B8D95D939C8E71197E278750B50FBD77" xlink:to="lab_us-gaap_AccruedLiabilitiesMember_B8D95D939C8E71197E278750B50FBD77" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Contingent Consideration [Line Items] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Contingent Consideration [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287" xlink:to="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_CA4E0557AE03A6C235CA8750B50F2287" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D_terseLabel_en-US" xlink:label="lab_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Severance costs </link:label>
<link:label id="lab_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D_label_en-US" xlink:label="lab_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Severance Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D" xlink:to="lab_us-gaap_SeveranceCosts1_CDA320CC5CAEEFC2B3D28750B50F712D" xlink:type="arc"/>
<link:label id="lab_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F_terseLabel_en-US" xlink:label="lab_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Aggregate fixed purchase provisions </link:label>
<link:label id="lab_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F_label_en-US" xlink:label="lab_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Purchase Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PurchaseObligation" xlink:label="loc_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F" xlink:to="lab_us-gaap_PurchaseObligation_154A22449BE84AA89BF08750B50F6E2F" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingAbstract_0DCFA866A5A21BED38718750B4FA0FD2_label_en-US" xlink:label="lab_us-gaap_SegmentReportingAbstract_0DCFA866A5A21BED38718750B4FA0FD2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_0DCFA866A5A21BED38718750B4FA0FD2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingAbstract_0DCFA866A5A21BED38718750B4FA0FD2" xlink:to="lab_us-gaap_SegmentReportingAbstract_0DCFA866A5A21BED38718750B4FA0FD2" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8_label_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8" xlink:to="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_D6E8BBB572B942BCA5B58750B4FA35A8" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A" xlink:to="lab_us-gaap_ConsolidationItemsAxis_EFE79004F717180A75038750B4FAC36A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487" xlink:to="lab_us-gaap_ConsolidationItemsDomain_FD92E84275AD00CC86C38750B4FA2487" xlink:type="arc"/>
<link:label id="lab_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80_verboseLabel_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intersegment Elimination </link:label>
<link:label id="lab_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80_label_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intersegment Eliminations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:label="loc_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80" xlink:to="lab_us-gaap_IntersegmentEliminationMember_BD6B3384FEF233A010608750B4FA8E80" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C" xlink:to="lab_us-gaap_ConcentrationRiskByTypeAxis_CA5C889F0A1CC4B2F44B8750B4FB7A0C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5" xlink:to="lab_us-gaap_ConcentrationRiskTypeDomain_97283D5B4E4F014824998750B4FB33B5" xlink:type="arc"/>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk </link:label>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7_label_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7" xlink:to="lab_us-gaap_CustomerConcentrationRiskMember_C50687CB2172EE96502B8750B4FB7EB7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B" xlink:to="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_DE7141678647AB1FDE158750B4FB401B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15" xlink:to="lab_us-gaap_ConcentrationRiskBenchmarkDomain_232B49821404F20F17D18750B4FB4F15" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4" xlink:to="lab_us-gaap_SalesRevenueNetMember_C0D68D149BE3C629E1E98750B4FB25A4" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts Receivable </link:label>
<link:label id="lab_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97" xlink:to="lab_us-gaap_AccountsReceivableMember_3DAAE38B70551E52F2FE8750B4FB1B97" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797_label_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797" xlink:to="lab_us-gaap_SegmentReportingInformationLineItems_8B1E79EB09205931D75B8750B4FB1797" xlink:type="arc"/>
<link:label id="lab_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB_terseLabel_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of reportable segments </link:label>
<link:label id="lab_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB_label_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Reportable Segments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB" xlink:to="lab_us-gaap_NumberOfReportableSegments_0BA858342DB6CE5550398750B4FB7CFB" xlink:type="arc"/>
<link:label id="lab_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0_verboseLabel_en-US" xlink:label="lab_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment sales </link:label>
<link:label id="lab_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0_label_en-US" xlink:label="lab_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0" xlink:to="lab_us-gaap_Revenues_564A408EC676A6A39A088750B4FB4CA0" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment allocation of interest expense </link:label>
<link:label id="lab_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101_label_en-US" xlink:label="lab_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101" xlink:to="lab_us-gaap_InterestExpense_F602C64C70A58B5EC2918750B4FB3101" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2_verboseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of product revenue contributed by customer </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2" xlink:to="lab_us-gaap_ConcentrationRiskPercentage1_257DC33CED54658371018750B4FBE1F2" xlink:type="arc"/>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685_verboseLabel_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of customer represented </link:label>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685_label_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Number of Customers </link:label>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685_documentation_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of customer representation. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ConcentrationRiskNumberofCustomers" xlink:label="loc_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:to="lab_opk_ConcentrationRiskNumberofCustomers_BDBD8E7472A23FEA3BE08750B4FB2685" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Information Related to the Senior Notes </link:label>
<link:label id="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5" xlink:to="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_E14E2E84894142A274815F8794E1B2E5" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inputs to Lattice Model Used to Value the Embedded Derivative </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_45BC9C16493E61D38FED5F8794E1DAE9" xlink:type="arc"/>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88_verboseLabel_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value of the Senior Notes With and Without the Embedded Derivatives and Fair Value of the Embedded Derivatives </link:label>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88_label_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value of Notes With and Without Embedded Derivatives And Fair Value Of Embedded Derivatives [Table Text Block] </link:label>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88_documentation_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair value of notes with and without embedded derivatives and fair value of embedded derivatives. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" xlink:label="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:to="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_E2B0ADF85DE37F376F9A5F8794E14B88" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Lines of Credit </link:label>
<link:label id="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7_label_en-US" xlink:label="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Line of Credit Facilities [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock" xlink:label="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7" xlink:to="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_D0E3C918A7844B60F4A55F8794E2EDD7" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table] </link:label>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8_label_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8" xlink:to="lab_us-gaap_FairValueByBalanceSheetGroupingTable_930F7E76D706B29DEBCC5F8795BCBCE8" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping, Disclosure Item Amounts [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Basis [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB" xlink:to="lab_us-gaap_FairValueByMeasurementBasisAxis_40B7975FB445B9C5CC435F8795BD88FB" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosure Item Amounts [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282" xlink:to="lab_us-gaap_FairValueDisclosureItemAmountsDomain_04BE83A4E2F40A313C0E5F8795BD4282" xlink:type="arc"/>
<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4_terseLabel_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement </link:label>
<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4_label_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4" xlink:to="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_6C699F808970584157475F8795BD24C4" xlink:type="arc"/>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA_verboseLabel_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Carrying Value </link:label>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA_label_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reported Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA" xlink:to="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_5FD36A1C36480E1CD6465F8795BD59FA" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_B26BA632A445C6677C7E5F8795BD3672" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements Fair Value Hierarchy [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Hierarchy [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_260B19485C4A495E2F6A5F8795BD83AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Level 1 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 1 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B" xlink:to="lab_us-gaap_FairValueInputsLevel1Member_69B2B9C9EE2BDC828A475F8795BD558B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Level 2 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 2 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B" xlink:to="lab_us-gaap_FairValueInputsLevel2Member_31AA5B60D87BECD829A15F8795BD234B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Level 3 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 3 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85" xlink:to="lab_us-gaap_FairValueInputsLevel3Member_F1D42F29D4931549AD305F8795BE6A85" xlink:type="arc"/>
<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA_verboseLabel_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA_label_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Payable, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotesPayableFairValueDisclosure" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA" xlink:to="lab_us-gaap_NotesPayableFairValueDisclosure_E510BE9DB5EBAFD1A7EA5F8795BE95AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5189DE5A4B747FE6F76E5F8794D7CCC2_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5189DE5A4B747FE6F76E5F8794D7CCC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments and Hedging Activities Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5189DE5A4B747FE6F76E5F8794D7CCC2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5189DE5A4B747FE6F76E5F8794D7CCC2" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_5189DE5A4B747FE6F76E5F8794D7CCC2" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632_terseLabel_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632_label_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632" xlink:to="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C3E5099AFA306FE30F885F8794D7A632" xlink:type="arc"/>
<link:label id="lab_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D" xlink:to="lab_us-gaap_HedgingDesignationAxis_9222DAB64A8FD72F1EC65F8794D7499D" xlink:type="arc"/>
<link:label id="lab_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530" xlink:to="lab_us-gaap_HedgingDesignationDomain_E025EB6276B44AA958A55F8794D8F530" xlink:type="arc"/>
<link:label id="lab_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument </link:label>
<link:label id="lab_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5" xlink:to="lab_us-gaap_NondesignatedMember_06A763391699FA9BCD245F8794D802E5" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instrument Risk [Axis] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis_0290827E3E061E62A7365F8794D8863F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Contract Type [Domain] </link:label>
<link:label id="lab_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462_label_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Contract [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462" xlink:to="lab_us-gaap_DerivativeContractTypeDomain_670EAA1BA539E539C8465F8794D8F462" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E_verboseLabel_en-US" xlink:label="lab_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock options/warrants </link:label>
<link:label id="lab_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E_label_en-US" xlink:label="lab_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Option [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E" xlink:to="lab_us-gaap_StockOptionMember_EB035AD5673256BE56835F8794D8F71E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C_terseLabel_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Forward contracts </link:label>
<link:label id="lab_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C_label_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Forward Contracts [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C" xlink:to="lab_us-gaap_ForwardContractsMember_7CC9973E249B2804D4115F8794D8859C" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments, net </link:label>
<link:label id="lab_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7_label_en-US" xlink:label="lab_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentsMember" xlink:label="loc_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7" xlink:to="lab_us-gaap_InvestmentsMember_531AF012CC26183A0BEE5F8794D867F7" xlink:type="arc"/>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591_terseLabel_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, net of discount and estimated fair value of embedded derivatives </link:label>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591_label_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Three Percent Convertible, Senior Notes, Net of Discount and Estimated Fair Value of Embedded Derivatives [Member] </link:label>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591_documentation_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Three Percent Convertible, Senior Notes, Net of Discount and Estimated Fair Value of Embedded Derivatives [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" xlink:label="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:to="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_CF5DF29462FD0742625C5F8794D8B591" xlink:type="arc"/>
<link:label id="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB_terseLabel_en-US" xlink:label="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized gains on forward contracts are recorded in Prepaid expenses and other current assets. Unrealized losses on forward contracts are recorded in Accrued expenses. </link:label>
<link:label id="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB_label_en-US" xlink:label="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expenses and Other Current Assets (Accrued Expenses) [Member] </link:label>
<link:label id="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB_documentation_en-US" xlink:label="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Prepaid Expenses and Other Current Assets (Accrued Expenses) [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember" xlink:label="loc_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:to="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_221271EC955444A4DF4D5F8794D80FEB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A_label_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A" xlink:to="lab_us-gaap_DerivativesFairValueLineItems_E1A321DF688370E59D615F8794D8866A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative asset, fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Asset, Fair Value, Gross Asset </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_6916A0544968BE5784AD5F8794D892B8" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative liability, fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Gross Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4B413E192D74AFEC40F25F8794D809A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_64C08FC45116BD17C89A8750B50690D9_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_64C08FC45116BD17C89A8750B50690D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Organization, Consolidation and Presentation of Financial Statements [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_64C08FC45116BD17C89A8750B50690D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_64C08FC45116BD17C89A8750B50690D9" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_64C08FC45116BD17C89A8750B50690D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818" xlink:to="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_25025180B96256813B508750B506C818" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF" xlink:to="lab_us-gaap_DebtInstrumentAxis_B5C42D21D787061BB9E28750B5066DEF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D" xlink:to="lab_us-gaap_DebtInstrumentNameDomain_771D291AC7FCC25AA00C8750B506A80D" xlink:type="arc"/>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D_label_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D_documentation_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PharmsynthezNoteReceivableMember" xlink:label="loc_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:to="lab_opk_PharmsynthezNoteReceivableMember_B7DE7D5F677B22A40BB08750B506FB3D" xlink:type="arc"/>
<link:label id="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez </link:label>
<link:label id="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045_label_en-US" xlink:label="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:label id="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045_documentation_en-US" xlink:label="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:to="lab_opk_PharmsynthezMember_6A973A748DD74F15B3C88750B507A045" xlink:type="arc"/>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648_terseLabel_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Rxi Pharmaceuticals Corporation </link:label>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648_label_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Rxi Pharmaceuticals Corporation [Member] </link:label>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648_documentation_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Rxi pharmaceuticals corporation. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_RxiPharmaceuticalsCorporationMember" xlink:label="loc_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:to="lab_opk_RxiPharmaceuticalsCorporationMember_6C5C6E86F1BE5CA879818750B5078648" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA_terseLabel_en-US" xlink:label="lab_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:label id="lab_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA_label_en-US" xlink:label="lab_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA" xlink:to="lab_us-gaap_RangeAxis_8292EF475E63E18321558750B50796CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48_terseLabel_en-US" xlink:label="lab_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:label id="lab_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48_label_en-US" xlink:label="lab_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48" xlink:to="lab_us-gaap_RangeMember_B9A4B05FAE87221F732B8750B5074E48" xlink:type="arc"/>
<link:label id="lab_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7_terseLabel_en-US" xlink:label="lab_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Minimum </link:label>
<link:label id="lab_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7_label_en-US" xlink:label="lab_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Minimum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7" xlink:to="lab_us-gaap_MinimumMember_26D4CAFAF006D6E255F88750B507C5A7" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum </link:label>
<link:label id="lab_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6_label_en-US" xlink:label="lab_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Maximum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6" xlink:to="lab_us-gaap_MaximumMember_F901AACD633F83F27A728750B50778A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E_terseLabel_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:label id="lab_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E_label_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E" xlink:to="lab_us-gaap_CounterpartyNameAxis_89E4CA1142BB099AD3848750B5070E1E" xlink:type="arc"/>
<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4" xlink:to="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_E424A1CC5D3382C481538750B50725C4" xlink:type="arc"/>
<link:label id="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F_terseLabel_en-US" xlink:label="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pfizer </link:label>
<link:label id="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F_label_en-US" xlink:label="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pfizer [Member] </link:label>
<link:label id="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F_documentation_en-US" xlink:label="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pfizer [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PfizerMember" xlink:label="loc_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:to="lab_opk_PfizerMember_85C77C9834D6B5C9DC628750B507B92F" xlink:type="arc"/>
<link:label id="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C_terseLabel_en-US" xlink:label="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Tesaro </link:label>
<link:label id="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C_label_en-US" xlink:label="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Tesaro [Member] </link:label>
<link:label id="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C_documentation_en-US" xlink:label="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tesaro [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:to="lab_opk_TesaroMember_A06D1B4CA1A3063129E98750B508863C" xlink:type="arc"/>
<link:label id="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43_terseLabel_en-US" xlink:label="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Merck </link:label>
<link:label id="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43_label_en-US" xlink:label="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Merck [Member] </link:label>
<link:label id="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43_documentation_en-US" xlink:label="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Merck [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_MerckMember" xlink:label="loc_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:to="lab_opk_MerckMember_C2B63AFF4B49FCD44F108750B5084B43" xlink:type="arc"/>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305_label_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305" xlink:to="lab_us-gaap_TypeOfArrangementAxis_58524B4E96E109ACB7188750B508A305" xlink:type="arc"/>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A_terseLabel_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A_label_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A" xlink:to="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3F1F3A9EE3EBF7687DF48750B508647A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollaborativeArrangementProductAgreementMember" xlink:label="loc_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9" xlink:to="lab_us-gaap_CollaborativeArrangementProductAgreementMember_684882C40E96D430BB198750B5080EE9" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05" xlink:to="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_14754907D87637038AF18750B5081A05" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-refundable and non-creditable upfront payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D_label_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementUpfrontPayment" xlink:label="loc_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:to="lab_opk_CollaborativeArrangementUpfrontPayment_FFAAA64B74B609E6D73B8750B508CC0D" xlink:type="arc"/>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D_verboseLabel_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from transfer of intellectual property and other </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D_label_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D_documentation_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_RevenueFromTransferOfIntellectualProperty" xlink:label="loc_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:to="lab_opk_RevenueFromTransferOfIntellectualProperty_29C78145B1D60D9A92AB87532FEEF89D" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment to be received </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6_label_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangement.MaximumMilestonePayments" xlink:label="loc_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:to="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_1F4F058E35F2F1A7F4CC8750B50824B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29_label_en-US" xlink:label="lab_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29" xlink:to="lab_us-gaap_DeferredRevenue_0E5766C0BBA4B483DA0F8750B5081C29" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Each milestone payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementMilestonePayment" xlink:label="loc_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:to="lab_opk_CollaborativeArrangementMilestonePayment_67F3B36CB265536FB7658750B50886F7" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Grant repayment </link:label>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84_label_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Grant Repayment </link:label>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Grant Repayment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementGrantRepayment" xlink:label="loc_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:to="lab_opk_CollaborativeArrangementGrantRepayment_A5E7E860FC49B43E739E8750B5083E84" xlink:type="arc"/>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16_terseLabel_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Upfront payment under license agreements </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16_label_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16_documentation_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment" xlink:label="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:to="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_06B71FEBBD178DF1C9EA8750B5086A16" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementMilestonePaymentReceived" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:to="lab_opk_CollaborativeArrangementMilestonePaymentReceived_74082724C5EA34FEAE628750B5087F5E" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6_label_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeAgreementAdditionalMilestonePayment" xlink:label="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:to="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_03138A74C228C2709E498750B50862A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE_terseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone revenue recognized </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Milestone Method, Revenue Recognized </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE" xlink:to="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_8418BDD4302E86D2F5F38750B508C3AE" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Period from first commercial sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214_label_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeAgreementPeriodfromFirstCommercialSale" xlink:label="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:to="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_0B0610900E72AB5E37A88750B508C214" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amount payable each year </link:label>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627_label_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Amount Payable Each Year </link:label>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Amount Payable Each Year </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementAmountPayableEachYear" xlink:label="loc_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:to="lab_opk_CollaborativeArrangementAmountPayableEachYear_D910EE1BB253913EBD478750B5095627" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Period for yearly payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03_label_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Period for Yearly Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Period for Yearly Payment </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CollaborativeArrangementPeriodforYearlyPayment" xlink:label="loc_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:to="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_320B0A3AD42B1AC477FA8750B509FB03" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, estimated useful lives </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Asset, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FCB98CDC3B96860B97F68750B509D193" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Debt face amount </link:label>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Face Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF" xlink:to="lab_us-gaap_DebtInstrumentFaceAmount_88C5374275B6771332518750B50992FF" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F_verboseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payments </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Estimated Milestone Payments To Be Received </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estimated milestone payment to be received. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" xlink:label="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:to="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_DF1DFCE7647EE0AA1BB68750B509A46F" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ASSETS </link:label>
<link:label id="lab_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B" xlink:to="lab_us-gaap_AssetsAbstract_277CA4D57B5A0B56C2EC8D8CC460361B" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current assets: </link:label>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782_label_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782" xlink:to="lab_us-gaap_AssetsCurrentAbstract_21E32DB5E094F3D963498D8CC462A782" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, at Carrying Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_3FBDDC7843AB81468AB98D8CC463D572" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D" xlink:to="lab_us-gaap_AccountsReceivableNetCurrent_61DFA7C63168CA6491C78D8CC463D93D" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventory </link:label>
<link:label id="lab_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215_label_en-US" xlink:label="lab_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215" xlink:to="lab_us-gaap_InventoryNet_193420F0E7C854E8A11A8D8CC4633215" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5_verboseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_035A7582E7EA9C26A8F08D8CC46378B5" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current assets </link:label>
<link:label id="lab_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099_label_en-US" xlink:label="lab_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099" xlink:to="lab_us-gaap_AssetsCurrent_83468EFF6F8E3DADEFDC8D8CC463B099" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610_verboseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, net </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentNet_65B1B1E7CD39FD6A10A08D8CC463E610" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet_C05A512A83DFD66AC0138D8CC46434EC" xlink:type="arc"/>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5_verboseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> In-process research and development </link:label>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Indefinite-Lived Intangible Assets (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_CF07EF77D1E5512C9EF18D8CC4642EC5" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_0D0B3D7770B9D9D6A9CF8D8CC464355E_verboseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_0D0B3D7770B9D9D6A9CF8D8CC464355E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_0D0B3D7770B9D9D6A9CF8D8CC464355E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_0D0B3D7770B9D9D6A9CF8D8CC464355E" xlink:to="lab_us-gaap_Goodwill_0D0B3D7770B9D9D6A9CF8D8CC464355E" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments, net </link:label>
<link:label id="lab_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928_label_en-US" xlink:label="lab_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928" xlink:to="lab_us-gaap_LongTermInvestments_5520CC2F2832CD965CA78D8CC464E928" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4_label_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4" xlink:to="lab_us-gaap_OtherAssetsNoncurrent_09984F7B4C235AB5D0858D8CC4646BA4" xlink:type="arc"/>
<link:label id="lab_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973_totalLabel_en-US" xlink:label="lab_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973_label_en-US" xlink:label="lab_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973" xlink:to="lab_us-gaap_Assets_03659DDE179583CB287D8D8CC4646973" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> LIABILITIES AND EQUITY </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_942FB3F711EFAD1B93D28D8CC464D2D3" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C" xlink:to="lab_us-gaap_LiabilitiesCurrentAbstract_2829338E74C314B6C8948D8CC4640D6C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40_label_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Payable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40" xlink:to="lab_us-gaap_AccountsPayableCurrent_FD8F6E13EB3E33E9E5008D8CC4646C40" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrent_2ABF630A086613123C908D8CC464C6DD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of lines of credit and notes payable </link:label>
<link:label id="lab_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7_label_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7" xlink:to="lab_us-gaap_LongTermDebtCurrent_C3ABDBA1662A46C3E2968D8CC46424D7" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431" xlink:to="lab_us-gaap_LiabilitiesCurrent_013C4E0AD9F56F995BC28D8CC4649431" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes and estimated fair value of embedded derivatives, net of discount </link:label>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2_label_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2" xlink:to="lab_us-gaap_ConvertibleLongTermNotesPayable_B5DFB0CD55ED7A94C81F8D8CC464D8C2" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liabilities, net </link:label>
<link:label id="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Income Tax Liabilities, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D" xlink:to="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_FB7E4354F891DE850FCE8E3FDB4CA09D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liabilities, net </link:label>
<link:label id="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Tax Liabilities, Net, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD" xlink:to="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_BECCECB0900CC94317EE8D8CC465D9BD" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities, principally deferred revenue and line of credit </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrent_A450B44B3EAE42310BA78D8CC4658062" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total long-term liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359_label_en-US" xlink:label="lab_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359" xlink:to="lab_us-gaap_LiabilitiesNoncurrent_F96856D79EA68A5E47748D8CC465D359" xlink:type="arc"/>
<link:label id="lab_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E_label_en-US" xlink:label="lab_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E" xlink:to="lab_us-gaap_Liabilities_C3E950A507B3E3CB20A78D8CC4659D7E" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity: </link:label>
<link:label id="lab_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768" xlink:to="lab_us-gaap_StockholdersEquityAbstract_2A02E65AFD3882445A518D8CC4656768" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock - $0.01 par value, 750,000,000 shares authorized; 547,980,417 and 546,188,516 shares issued at March 31, 2016 and December 31, 2015, respectively </link:label>
<link:label id="lab_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621_label_en-US" xlink:label="lab_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Value, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621" xlink:to="lab_us-gaap_CommonStockValue_6E71F061D95BECB6DFAF8D8CC4655621" xlink:type="arc"/>
<link:label id="lab_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B_negatedLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Treasury Stock - 586,760 and 1,120,367 shares at March 31, 2016 and December 31, 2015, respectively </link:label>
<link:label id="lab_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B_label_en-US" xlink:label="lab_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock, Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B" xlink:to="lab_us-gaap_TreasuryStockValue_E776DCA07FCF616DFB318D8CC465D93B" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C_verboseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Additional paid-in capital </link:label>
<link:label id="lab_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Additional Paid in Capital </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C" xlink:to="lab_us-gaap_AdditionalPaidInCapital_7431D0C4FA26263300DC8D8CC465A85C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49_verboseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated other comprehensive loss </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A5CDBB8E96A4CB4EAE7C8D8CC4653B49" xlink:type="arc"/>
<link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385_verboseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated deficit </link:label>
<link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retained Earnings (Accumulated Deficit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385" xlink:to="lab_us-gaap_RetainedEarningsAccumulatedDeficit_48C4493712AD1B10973A8D8CC465A385" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total shareholders’ equity </link:label>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A" xlink:to="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9D7C2CFD0E7E55C50C728D8CC465FE7A" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities and equity </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquity_405A227D9D998B023F148D8CC465926E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountingPoliciesAbstract_5D689D3C8362AFB1BBBC8D9349D856D0_label_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract_5D689D3C8362AFB1BBBC8D9349D856D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_5D689D3C8362AFB1BBBC8D9349D856D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_5D689D3C8362AFB1BBBC8D9349D856D0" xlink:to="lab_us-gaap_AccountingPoliciesAbstract_5D689D3C8362AFB1BBBC8D9349D856D0" xlink:type="arc"/>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A_terseLabel_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A_label_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A_documentation_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:to="lab_opk_SummaryOfSignificantAccountingPoliciesTable_63498AA61E69B21504DF8D9349D8817A" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Tax Authority, Name [Axis] </link:label>
<link:label id="lab_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053_label_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Authority, Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityNameAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053" xlink:to="lab_us-gaap_IncomeTaxAuthorityNameAxis_0B47C5AE0C9461FA12198D9349D8D053" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Tax Authority, Name [Domain] </link:label>
<link:label id="lab_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C_label_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Authority, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityNameDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C" xlink:to="lab_us-gaap_IncomeTaxAuthorityNameDomain_2AB42CFB08EF868CD4C98D9349D8D54C" xlink:type="arc"/>
<link:label id="lab_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD_terseLabel_en-US" xlink:label="lab_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Israel Tax Authority </link:label>
<link:label id="lab_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD_label_en-US" xlink:label="lab_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Israel Tax Authority [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IsraelTaxAuthorityMember" xlink:label="loc_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD" xlink:to="lab_us-gaap_IsraelTaxAuthorityMember_CCD67D3F98B7C0D7D7228D9349D9CAAD" xlink:type="arc"/>
<link:label id="lab_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D_terseLabel_en-US" xlink:label="lab_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Health Care Organization, Revenue Sources [Axis] </link:label>
<link:label id="lab_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D_label_en-US" xlink:label="lab_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Health Care Organization, Revenue Sources [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HealthCareOrganizationRevenueSourcesAxis" xlink:label="loc_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D" xlink:to="lab_us-gaap_HealthCareOrganizationRevenueSourcesAxis_F99D88AC3BC12A9FE1648D9349D93A2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF_terseLabel_en-US" xlink:label="lab_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Health Care Organization, Revenue Sources [Domain] </link:label>
<link:label id="lab_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF_label_en-US" xlink:label="lab_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Health Care Organization, Revenue Sources [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HealthCareOrganizationRevenueSourcesDomain" xlink:label="loc_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF" xlink:to="lab_us-gaap_HealthCareOrganizationRevenueSourcesDomain_4482EAE13D1FB1358DA78D9349D953AF" xlink:type="arc"/>
<link:label id="lab_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9_terseLabel_en-US" xlink:label="lab_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Self-Pay </link:label>
<link:label id="lab_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9_label_en-US" xlink:label="lab_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Self-Pay [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SelfPayMember" xlink:label="loc_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9" xlink:to="lab_us-gaap_SelfPayMember_844DD6664C85B6D62C9D8D9349D948A9" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB40506E50B4BDDC2DEC8D9349D98CB8" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_56DC96132C20F50ACDCD8D9349D9BBDF" xlink:type="arc"/>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1_terseLabel_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Software </link:label>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1_label_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Software and Software Development Costs [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1" xlink:to="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_C915AA5B6869E124BF5C8D9349D92FE1" xlink:type="arc"/>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5_terseLabel_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Machinery, Medical and Other Equipment </link:label>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5_label_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Machinery and Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5" xlink:to="lab_us-gaap_MachineryAndEquipmentMember_91D022EC8EE1FC066F188D9349D92ED5" xlink:type="arc"/>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438_terseLabel_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures </link:label>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438_label_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438" xlink:to="lab_us-gaap_FurnitureAndFixturesMember_033CBB1080ABF147180B8D9349D9A438" xlink:type="arc"/>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82_terseLabel_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Buildings and Improvements </link:label>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82_label_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Building and Building Improvements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82" xlink:to="lab_us-gaap_BuildingAndBuildingImprovementsMember_ADE4B9819CC2339F62CD8D9349D95C82" xlink:type="arc"/>
<link:label id="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525_terseLabel_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft </link:label>
<link:label id="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525_label_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft [Member] </link:label>
<link:label id="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525_documentation_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AutomobilesandAircraftMember" xlink:label="loc_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:to="lab_opk_AutomobilesandAircraftMember_B9A507A82AA894E42EBE8D9349D99525" xlink:type="arc"/>
<link:label id="lab_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003_terseLabel_en-US" xlink:label="lab_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Government Contracts Concentration Risk </link:label>
<link:label id="lab_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003_label_en-US" xlink:label="lab_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Government Contracts Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GovernmentContractsConcentrationRiskMember" xlink:label="loc_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003" xlink:to="lab_us-gaap_GovernmentContractsConcentrationRiskMember_7B3A0F10CBE94DABCA3B8D9349DA2003" xlink:type="arc"/>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12_terseLabel_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12_label_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12_documentation_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:to="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_7721A25E8C527429BB4E8D9349DAAC12" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provision for inventory obsolescence </link:label>
<link:label id="lab_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0_label_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Write-down </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryWriteDown" xlink:label="loc_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0" xlink:to="lab_us-gaap_InventoryWriteDown_4960FC98DC10118407C18D9349DAF3E0" xlink:type="arc"/>
<link:label id="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3_terseLabel_en-US" xlink:label="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pre-launch Inventory </link:label>
<link:label id="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3_label_en-US" xlink:label="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pre-launch Inventory </link:label>
<link:label id="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3_documentation_en-US" xlink:label="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pre-launch Inventory </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PrelaunchInventory" xlink:label="loc_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:to="lab_opk_PrelaunchInventory_17DAF2B3033E5A3285128D9349DB1CF3" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill, in-process research and development and other intangible assets acquired </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_AA09D60380E95596EBDD8D9349DB876C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of intangible assets </link:label>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Intangible Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535" xlink:to="lab_us-gaap_AmortizationOfIntangibleAssets_2C314248E99DBDA803B08D9349DB0535" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Useful life </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1AB8BA9F68102AE907048D9349DBE6B1" xlink:type="arc"/>
<link:label id="lab_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA_terseLabel_en-US" xlink:label="lab_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Depreciation expense </link:label>
<link:label id="lab_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA_label_en-US" xlink:label="lab_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Depreciation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA" xlink:to="lab_us-gaap_Depreciation_59502DAA62CD4C8823098D9349DBE2AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC_terseLabel_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate income tax rate </link:label>
<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC_label_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC" xlink:to="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_71049AE2F0727592E4448D9349DB0EEC" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_DEAF447E1618E401DA628D9349DB472C_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_DEAF447E1618E401DA628D9349DB472C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_DEAF447E1618E401DA628D9349DB472C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskPercentage1_DEAF447E1618E401DA628D9349DB472C" xlink:to="lab_us-gaap_ConcentrationRiskPercentage1_DEAF447E1618E401DA628D9349DB472C" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenue_F66195BDFFF1C499AC438D9349DB3D82_verboseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenue_F66195BDFFF1C499AC438D9349DB3D82" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total deferred revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_F66195BDFFF1C499AC438D9349DB3D82" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenue_F66195BDFFF1C499AC438D9349DB3D82" xlink:to="lab_us-gaap_DeferredRevenue_F66195BDFFF1C499AC438D9349DB3D82" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, gross </link:label>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Gross, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349" xlink:to="lab_us-gaap_AccountsReceivableGrossCurrent_187E0ED36F633214775D8D9349DB8349" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3_terseLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts receivable </link:label>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3_label_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts Receivable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_EF0014BDE9F2B47D9C138D9349DB98C3" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F_terseLabel_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provision for bad debts </link:label>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F_label_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Provision for Doubtful Accounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F" xlink:to="lab_us-gaap_ProvisionForDoubtfulAccounts_EB2BDDC5DEDD1D7466E68D9349DBA42F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation expense </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3" xlink:to="lab_us-gaap_ShareBasedCompensation_7CDF92AE883CC0BCA8018D9349DB82A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventsAbstract_FC50C1F2ED10B908DC488D9347E40053_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsAbstract_FC50C1F2ED10B908DC488D9347E40053" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Events [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_FC50C1F2ED10B908DC488D9347E40053" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsAbstract_FC50C1F2ED10B908DC488D9347E40053" xlink:to="lab_us-gaap_SubsequentEventsAbstract_FC50C1F2ED10B908DC488D9347E40053" xlink:type="arc"/>
<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895_terseLabel_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Development and License Agreement </link:label>
<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895_label_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Development and License Agreement [Member] </link:label>
<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895_documentation_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Development and License Agreement [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DevelopmentandLicenseAgreementMember" xlink:label="loc_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:to="lab_opk_DevelopmentandLicenseAgreementMember_22C0EEEFB87BDD03383A8DF4E9220895" xlink:type="arc"/>
<link:label id="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69_terseLabel_en-US" xlink:label="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Exclusive Option </link:label>
<link:label id="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69_label_en-US" xlink:label="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Exclusive Option [Member] </link:label>
<link:label id="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69_documentation_en-US" xlink:label="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Exclusive Option [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ExclusiveOptionMember" xlink:label="loc_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:to="lab_opk_ExclusiveOptionMember_3B20E29B8EBDC0729E9D8DF5A0445C69" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462_terseLabel_en-US" xlink:label="lab_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Scenario [Axis] </link:label>
<link:label id="lab_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462_label_en-US" xlink:label="lab_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Scenario [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462" xlink:to="lab_us-gaap_StatementScenarioAxis_B7300AB09CAA2B108BDF8DE92591A462" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4_terseLabel_en-US" xlink:label="lab_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Scenario, Unspecified [Domain] </link:label>
<link:label id="lab_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4_label_en-US" xlink:label="lab_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Scenario, Unspecified [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4" xlink:to="lab_us-gaap_ScenarioUnspecifiedDomain_590DCAA22EA1A55705A38DE925BCE4C4" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B_terseLabel_en-US" xlink:label="lab_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Scenario, Forecast </link:label>
<link:label id="lab_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B_label_en-US" xlink:label="lab_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Scenario, Forecast [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B" xlink:to="lab_us-gaap_ScenarioForecastMember_E7D3C2BFC530FA6E11B68DE94E123E3B" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Axis] </link:label>
<link:label id="lab_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8" xlink:to="lab_us-gaap_SubsequentEventTypeAxis_5AA1E5851E96D35D24668D9347E441F8" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Domain] </link:label>
<link:label id="lab_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405" xlink:to="lab_us-gaap_SubsequentEventTypeDomain_4B8EA00B08FF1996E5238D9347E40405" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event </link:label>
<link:label id="lab_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49_label_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49" xlink:to="lab_us-gaap_SubsequentEventMember_771595531E2F7F4C287D8D9347E40E49" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_055E354092744A6FA25C8D9347E4848E_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_055E354092744A6FA25C8D9347E4848E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Convertible Notes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_055E354092744A6FA25C8D9347E4848E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleNotesPayableMember_055E354092744A6FA25C8D9347E4848E" xlink:to="lab_us-gaap_ConvertibleNotesPayableMember_055E354092744A6FA25C8D9347E4848E" xlink:type="arc"/>
<link:label id="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F_terseLabel_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 </link:label>
<link:label id="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F_label_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 [Member] </link:label>
<link:label id="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F_documentation_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:to="lab_opk_NotesDueFebruary12033Member_E4448431B8430A4704B48D9347E4637F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock trigger price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142" xlink:to="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_DBB37FE15055281C20008D9347E49142" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Convertible debt, threshold percentage of stock price trigger </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_28E185685B8D61931EB28D9347E5BF38" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion price per share </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_3FCC7846AD811515D3788D9347E54F43" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of trading days </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_F790C65D5224B75BC6048D9347E53F40" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of consecutive trading days applicable conversion price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Consecutive Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_16247511CF0686BA3A8B8D9347E520B6" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion right triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D_label_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D_documentation_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtInstrumentConvertibleConversionRightTriggered" xlink:label="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:to="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_FCF3FC646F4F3724230A8D9347E5440D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Conversion rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Ratio </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_9E68EF372D2B9B11C0958D9347E59270" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> License revenue, initial payment </link:label>
<link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from License Fees Received </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF" xlink:to="lab_us-gaap_ProceedsFromLicenseFeesReceived_CBAC7783745F5A0EA4BF8DC009AF20CF" xlink:type="arc"/>
<link:label id="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2_terseLabel_en-US" xlink:label="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> License fees, collection period after effective date of agreement </link:label>
<link:label id="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2_label_en-US" xlink:label="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> License Fees, Collection Period After Effective Date of Agreement </link:label>
<link:label id="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2_documentation_en-US" xlink:label="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> License Fees, Collection Period After Effective Date of Agreement </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement" xlink:label="loc_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:to="lab_opk_LicenseFeesCollectionPeriodAfterEffectiveDateofAgreement_0DA91A55C058B764B90D8DC50A04A4D2" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_F3EE71A497A17DFD879E8DC99D908229_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_F3EE71A497A17DFD879E8DC99D908229" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Aggregate milestone revenue, maximum </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_F3EE71A497A17DFD879E8DC99D908229" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_F3EE71A497A17DFD879E8DC99D908229" xlink:to="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_F3EE71A497A17DFD879E8DC99D908229" xlink:type="arc"/>
<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38_terseLabel_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Royalty revenue, obligation period after first product sale </link:label>
<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38_label_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Royalty Revenue, Obligation Period </link:label>
<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38_documentation_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Royalty Revenue, Obligation Period </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_RoyaltyRevenueObligationPeriod" xlink:label="loc_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:to="lab_opk_RoyaltyRevenueObligationPeriod_215E87BB74A6193CFAD98DCE69624C38" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E_terseLabel_en-US" xlink:label="lab_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Table] </link:label>
<link:label id="lab_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E_label_en-US" xlink:label="lab_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Table] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentTable" xlink:label="loc_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E" xlink:to="lab_invest_InvestmentTable_97B41C18C1866450CFDF873AA4EE587E" xlink:type="arc"/>
<link:label id="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B_terseLabel_en-US" xlink:label="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ChromaDex </link:label>
<link:label id="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B_label_en-US" xlink:label="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ChromaDex [Member] </link:label>
<link:label id="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B_documentation_en-US" xlink:label="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ChromaDex. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ChromaDexMember" xlink:label="loc_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:to="lab_opk_ChromaDexMember_F2F2E43939DFE7E9FCCA873AA4EF7A0B" xlink:type="arc"/>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42_terseLabel_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> MabVax </link:label>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42_label_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MabVax Therapeutics Holdings, Inc. [Member] </link:label>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42_documentation_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> MabVax Therapeutics Holdings, Inc. [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_MabVaxTherapeuticsHoldingsInc.Member" xlink:label="loc_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:to="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_5A091E959300758EA6EF873AA4EFBA42" xlink:type="arc"/>
<link:label id="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E_terseLabel_en-US" xlink:label="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ARNO </link:label>
<link:label id="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E_label_en-US" xlink:label="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ARNO [Member] </link:label>
<link:label id="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E_documentation_en-US" xlink:label="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ARNO [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ARNOMember" xlink:label="loc_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:to="lab_opk_ARNOMember_FFF8EA8BFA56E5CC0D56873AA4EF075E" xlink:type="arc"/>
<link:label id="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE_terseLabel_en-US" xlink:label="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Xenetic Biosciences, Inc. </link:label>
<link:label id="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE_label_en-US" xlink:label="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Xenetic Biosciences, Inc. [Member] </link:label>
<link:label id="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE_documentation_en-US" xlink:label="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Xenetic Biosciences, Inc. [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_XeneticBiosciencesInc.Member" xlink:label="loc_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:to="lab_opk_XeneticBiosciencesInc.Member_1B190D937BBE2178B28E873AA4EFA9DE" xlink:type="arc"/>
<link:label id="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E_terseLabel_en-US" xlink:label="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Neovasc </link:label>
<link:label id="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E_label_en-US" xlink:label="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Neovasc [Member] </link:label>
<link:label id="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E_documentation_en-US" xlink:label="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Neovasc [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_NeovascMember" xlink:label="loc_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:to="lab_opk_NeovascMember_777C50649AACE3FC80B4873AA4EF002E" xlink:type="arc"/>
<link:label id="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC_terseLabel_en-US" xlink:label="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cocrystal </link:label>
<link:label id="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC_label_en-US" xlink:label="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cocrystal [Member] </link:label>
<link:label id="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC_documentation_en-US" xlink:label="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cocrystal. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:to="lab_opk_CocrystalMember_14938DB30D6D55A53F94873AA4EF51BC" xlink:type="arc"/>
<link:label id="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F_terseLabel_en-US" xlink:label="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sevion </link:label>
<link:label id="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F_label_en-US" xlink:label="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sevion [Member] </link:label>
<link:label id="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F_documentation_en-US" xlink:label="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Sevion [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SevionMember" xlink:label="loc_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:to="lab_opk_SevionMember_A43208FA5111AADDFE9C873AA4EFB54F" xlink:type="arc"/>
<link:label id="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A_terseLabel_en-US" xlink:label="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc </link:label>
<link:label id="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A_label_en-US" xlink:label="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc [Member] </link:label>
<link:label id="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A_documentation_en-US" xlink:label="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_InCellDxIncMember" xlink:label="loc_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:to="lab_opk_InCellDxIncMember_28E6C7CDBD0F74B0F20787462379451A" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892_terseLabel_en-US" xlink:label="lab_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Line Items] </link:label>
<link:label id="lab_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892_label_en-US" xlink:label="lab_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentLineItems" xlink:label="loc_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892" xlink:to="lab_invest_InvestmentLineItems_E0059DC2FE000C746ADA873AA4EF4892" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C_terseLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C_label_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C_documentation_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:to="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_32E47D8EE62C31DFFDA5873AA4EFA24C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523_verboseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Warrants to purchase common shares </link:label>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Warrant or Right, Number of Securities Called by Warrants or Rights </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523" xlink:to="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FC001CB6D54A0D262043873AA4EF1523" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E_verboseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUBSEQUENT EVENTS </link:label>
<link:label id="lab_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Events [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E" xlink:to="lab_us-gaap_SubsequentEventsTextBlock_67E33A3C1B9DBEB543BA5F8795B0CF4E" xlink:type="arc"/>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B_verboseLabel_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Basis of Presentation </link:label>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B_label_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Basis of Accounting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B" xlink:to="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_DEA84C91BBF702BAF27186EAFF306B1B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Principles of Consolidation </link:label>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B_label_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B" xlink:to="lab_us-gaap_ConsolidationPolicyTextBlock_3BDC8125D6C947D6C5D186EAFF30DD2B" xlink:type="arc"/>
<link:label id="lab_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554_verboseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Use of Estimates </link:label>
<link:label id="lab_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Use of Estimates, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554" xlink:to="lab_us-gaap_UseOfEstimates_4CF745F8E2093ACE42F286EAFF308554" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D" xlink:to="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_4448F7A5B2202C9FD53586EAFF31284D" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories </link:label>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4_label_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4" xlink:to="lab_us-gaap_InventoryPolicyTextBlock_5670799A86654FB1C17186EAFF311EB4" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6_verboseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets </link:label>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_DC4B08767FC7F2A5A5CF86EAFF3176F6" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3" xlink:to="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_032BE9486E722ED052C786EAFF3167D3" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent Consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA" xlink:to="lab_us-gaap_BusinessCombinationsPolicy_B0CB0357C49B611DCFE886EAFF319BCA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Financial Instruments </link:label>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock_653E92ACC5F93E904E1786EAFF317FC4" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue Recognition </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063" xlink:to="lab_us-gaap_RevenueRecognitionPolicyTextBlock_EEF1DF4DFD90B34E753886EAFF31D063" xlink:type="arc"/>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A_verboseLabel_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Concentration of Credit Risk and Allowance for Doubtful Accounts </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A_label_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts [Policy Text Block] </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A_documentation_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:label="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:to="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_08A828EFF4DACE135ECE86EAFF31218A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027_verboseLabel_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based Compensation </link:label>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027_label_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Compensation Related Costs, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CompensationRelatedCostsPolicyTextBlock" xlink:label="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027" xlink:to="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_E4B72AA0894D19F2663986EAFF31A027" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_DFC762459DB816354FEB86EAFF31A501" xlink:type="arc"/>
<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Impairment of Long-Lived Assets </link:label>
<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B_label_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:label="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B" xlink:to="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_BABFE9BC20FEAC20A2E886EAFF312E7B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Research and Development Expenses </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_3860CD8000190E9FED8486EAFF3107E7" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814_verboseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reporting </link:label>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814_label_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814" xlink:to="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_0A257C522078A667C6E986EAFF31E814" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entities </link:label>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B_label_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Variable Interest Entity, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:label="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B" xlink:to="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_D39A2850682A240E319686EAFF31386B" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9_label_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_EF41CB530824B99F914D86EAFF31D9D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Taxes </link:label>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0_label_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0" xlink:to="lab_us-gaap_IncomeTaxPolicyTextBlock_FD1DB1C6CE2C1A1868DF86EAFF318AF0" xlink:type="arc"/>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Recent Accounting Pronouncements </link:label>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A" xlink:to="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_D1ED6F1077CE6DB5FC8A86EAFF31218A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Related Party Transactions, by Related Party [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Related Party Transactions, by Related Party [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA" xlink:to="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_A70988144F9502DBFD839666D44CAFDA" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series C Preferred Stock </link:label>
<link:label id="lab_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477_label_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Series C Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477" xlink:to="lab_us-gaap_SeriesCPreferredStockMember_BE36CE100B4A9E42731D9666D44C3477" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock </link:label>
<link:label id="lab_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC_label_en-US" xlink:label="lab_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC" xlink:to="lab_us-gaap_CommonStockMember_C99B5CDC255140EE29BD9666D44C41EC" xlink:type="arc"/>
<link:label id="lab_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series A-2 Preferred Stock </link:label>
<link:label id="lab_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466_label_en-US" xlink:label="lab_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466" xlink:to="lab_us-gaap_PreferredStockMember_5F652C030E6C5B793D309666D44CF466" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Axis] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8" xlink:to="lab_us-gaap_RelatedPartyTransactionAxis_555B7157D90E882F8F359666D44CCAA8" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Domain] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20" xlink:to="lab_us-gaap_RelatedPartyTransactionDomain_4BCF042C5D8A57F7550D9666D44CCE20" xlink:type="arc"/>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170_terseLabel_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense </link:label>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170_label_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense [Member] </link:label>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170_documentation_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ReimbursementOfTravelExpenseMember" xlink:label="loc_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:to="lab_opk_ReimbursementOfTravelExpenseMember_0708BB4831FE130DF6C09666D44D6170" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party [Axis] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4" xlink:to="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A2843DF77194A8D8A4D19666D44D7EA4" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party [Domain] </link:label>
<link:label id="lab_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A_label_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A" xlink:to="lab_us-gaap_RelatedPartyDomain_F65784F2271F298AB7AC9666D44DEB8A" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Method Investee </link:label>
<link:label id="lab_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investee [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvesteeMember" xlink:label="loc_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C" xlink:to="lab_us-gaap_EquityMethodInvesteeMember_3F5CE6318F65558E72F79666D44D843C" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953_terseLabel_en-US" xlink:label="lab_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investee </link:label>
<link:label id="lab_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953_label_en-US" xlink:label="lab_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investee [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvesteeMember" xlink:label="loc_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953" xlink:to="lab_us-gaap_InvesteeMember_3D2D69AE61475D39400D9666D44D5953" xlink:type="arc"/>
<link:label id="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2_terseLabel_en-US" xlink:label="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dr Frost </link:label>
<link:label id="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2_label_en-US" xlink:label="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Dr Frost [Member] </link:label>
<link:label id="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2_documentation_en-US" xlink:label="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Dr Frost. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DrFrostMember" xlink:label="loc_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:to="lab_opk_DrFrostMember_2EA01846204EE5F65A9A9666D44D9DC2" xlink:type="arc"/>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410_verboseLabel_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Frost Real Estate Holdings LLC </link:label>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410_label_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Frost Real Estate Holdings LLC [Member] </link:label>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410_documentation_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Frost real estate holdings LLC. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FrostRealEstateHoldingsLLCMember" xlink:label="loc_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:to="lab_opk_FrostRealEstateHoldingsLLCMember_A53A8453354FC98065CB9666D44D7410" xlink:type="arc"/>
<link:label id="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6_verboseLabel_en-US" xlink:label="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ChromaDex Corporation </link:label>
<link:label id="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6_label_en-US" xlink:label="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Chromadex Corporation [Member] </link:label>
<link:label id="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6_documentation_en-US" xlink:label="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ChromaDex corporation. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ChromadexCorporationMember" xlink:label="loc_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:to="lab_opk_ChromadexCorporationMember_C2AF334E1DCC9A2C7F6C9666D44D89B6" xlink:type="arc"/>
<link:label id="lab_opk_CocrystalMember_30075CB78D7FF7E38D479666D44DB805_verboseLabel_en-US" xlink:label="lab_opk_CocrystalMember_30075CB78D7FF7E38D479666D44DB805" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COCP </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_30075CB78D7FF7E38D479666D44DB805" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CocrystalMember_30075CB78D7FF7E38D479666D44DB805" xlink:to="lab_opk_CocrystalMember_30075CB78D7FF7E38D479666D44DB805" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Line Items] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848" xlink:to="lab_us-gaap_RelatedPartyTransactionLineItems_1E238DCA6E7D14522CEA9666D44DD848" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_24A5C3D73AB938DE73AF9666D44E5E52_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_24A5C3D73AB938DE73AF9666D44E5E52" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investment, ownership percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_24A5C3D73AB938DE73AF9666D44E5E52" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_24A5C3D73AB938DE73AF9666D44E5E52" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_24A5C3D73AB938DE73AF9666D44E5E52" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_00DA1DDC7C051C77B0B09666D44E960E_verboseLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_00DA1DDC7C051C77B0B09666D44E960E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Available-for-sale investment, ownership percentage </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_00DA1DDC7C051C77B0B09666D44E960E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_00DA1DDC7C051C77B0B09666D44E960E" xlink:to="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_00DA1DDC7C051C77B0B09666D44E960E" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Invested in common shares </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA" xlink:to="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_5AC44CBC8E733D36A81B9666D44E67BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB_terseLabel_en-US" xlink:label="lab_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock price per share </link:label>
<link:label id="lab_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB_label_en-US" xlink:label="lab_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB" xlink:to="lab_us-gaap_SharePrice_FAC0BDCC6540F1E6AF8B9666D44E48CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional investment </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64" xlink:to="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_F7585DCA7BAFF9D849D39666D44E8D64" xlink:type="arc"/>
<link:label id="lab_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346_terseLabel_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Area of real estate property (in square feet) </link:label>
<link:label id="lab_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346_label_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Area of Real Estate Property </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AreaOfRealEstateProperty" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346" xlink:to="lab_us-gaap_AreaOfRealEstateProperty_8727DBD2C715DFD954269666D44EE346" xlink:type="arc"/>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lease payments per month in first year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OperatingLeasesMonthlyPaymentsYearOne" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_338A7F3D04E0100029799666D44E37C0" xlink:type="arc"/>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lease payments per month in fifth year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Five </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Five </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OperatingLeasesMonthlyPaymentsYearFive" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_A18181C52956ED689DD29666D44E2699" xlink:type="arc"/>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26_negatedTerseLabel_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Rent reduction </link:label>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26_label_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Tenant Improvements, Offset Against Operating Lease in Next Twelve Months </link:label>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26_documentation_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tenant Improvements, Offset Against Operating Lease in Next Twelve Months </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths" xlink:label="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:to="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_34D30EDABBA09D28254D9666D44E9C26" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement paid to related party for travel </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction, Expenses from Transactions with Related Party </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A" xlink:to="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_A4DFCEDA7FCBCDB2D7B19666D44E689A" xlink:type="arc"/>
<link:label id="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF_terseLabel_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> STRATEGIC ALLIANCES </link:label>
<link:label id="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF_label_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Strategic Alliances [Text Block] </link:label>
<link:label id="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF_documentation_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Strategic Alliances [Text Block] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StrategicAlliancesTextBlock" xlink:label="loc_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:to="lab_opk_StrategicAlliancesTextBlock_80620855835CDDD1DF2A5F8794A946BF" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_414D6C73E4FF2B2320CB5F8795AEBC0B_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract_414D6C73E4FF2B2320CB5F8795AEBC0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Cash Flows [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_414D6C73E4FF2B2320CB5F8795AEBC0B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_414D6C73E4FF2B2320CB5F8795AEBC0B" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract_414D6C73E4FF2B2320CB5F8795AEBC0B" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3_terseLabel_en-US" xlink:label="lab_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Table] </link:label>
<link:label id="lab_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3_label_en-US" xlink:label="lab_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3" xlink:to="lab_us-gaap_StatementTable_8520400CBB2597F13B125F8795AE59E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:label id="lab_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF_label_en-US" xlink:label="lab_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF" xlink:to="lab_us-gaap_StatementLineItems_2C3793A87B697A0E8BC65F8795AF19EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on notes payable </link:label>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Interest Rate, Stated Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FC6E29D3F1C57F4083815F8795AFC843" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> DEBT </link:label>
<link:label id="lab_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7" xlink:to="lab_us-gaap_DebtDisclosureTextBlock_E5E25D3F7BD276CAF7E05F87950161F7" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementAbstract_B6C37CC99CCBF778F2AF87E7EA97DD23_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract_B6C37CC99CCBF778F2AF87E7EA97DD23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_B6C37CC99CCBF778F2AF87E7EA97DD23" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementAbstract_B6C37CC99CCBF778F2AF87E7EA97DD23" xlink:to="lab_us-gaap_IncomeStatementAbstract_B6C37CC99CCBF778F2AF87E7EA97DD23" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenues: </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNetAbstract" xlink:label="loc_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8" xlink:to="lab_us-gaap_SalesRevenueNetAbstract_9FA67E9B0A562854D28C87E7EA97F2E8" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6_label_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Services, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6" xlink:to="lab_us-gaap_SalesRevenueServicesNet_8458D44C42B724BEB14387E7EA9841E6" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from products </link:label>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A_label_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Goods, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A" xlink:to="lab_us-gaap_SalesRevenueGoodsNet_4742F88479FAF827B4C087E7EA980F9A" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC_totalLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:label id="lab_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC" xlink:to="lab_us-gaap_SalesRevenueNet_129D3008ADD47FF1A19087E7EA98F3AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05_verboseLabel_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Costs and expenses: </link:label>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05_label_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingExpensesAbstract" xlink:label="loc_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05" xlink:to="lab_us-gaap_OperatingExpensesAbstract_95C144C7F5066C2A728587E7EA98EF05" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of service revenue </link:label>
<link:label id="lab_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B_label_en-US" xlink:label="lab_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostOfServices" xlink:label="loc_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B" xlink:to="lab_us-gaap_CostOfServices_EE722E9C723D65F8C84A87E7EA98E13B" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of product revenue </link:label>
<link:label id="lab_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0_label_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Goods Sold </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0" xlink:to="lab_us-gaap_CostOfGoodsSold_3DAE51B24E54BA1E486B87E7EA98C2F0" xlink:type="arc"/>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D_verboseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Selling, general and administrative </link:label>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D_label_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D" xlink:to="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1F154ACEE94DF146B64A87E7EA98753D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945_verboseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Research and development </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpense_479B4F8ECC0D7AFCB54587E7EA984945" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_7028D29EA34602B9D4D387E7EA98CABF" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total costs and expenses </link:label>
<link:label id="lab_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156_label_en-US" xlink:label="lab_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156" xlink:to="lab_us-gaap_OperatingExpenses_6BA8086471F1A63DBC3B87E7EA98E156" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Operating loss </link:label>
<link:label id="lab_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A_label_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A" xlink:to="lab_us-gaap_OperatingIncomeLoss_9F16941AB500CA59A0D087E7EA99041A" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net: </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_A013C961B4DFC840B7D087E7EA99B16D" xlink:type="arc"/>
<link:label id="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571_verboseLabel_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest income </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571_label_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571_documentation_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_InterestIncomeNonoperating" xlink:label="loc_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:to="lab_opk_InterestIncomeNonoperating_A450F1867179870D35CA87E7EA99C571" xlink:type="arc"/>
<link:label id="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA_negatedLabel_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Interest expense </link:label>
<link:label id="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA_label_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense, Nonoperating </link:label>
<link:label id="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA_documentation_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Expense, Nonoperating </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_InterestExpenseNonoperating" xlink:label="loc_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:to="lab_opk_InterestExpenseNonoperating_29BB08D854AC2D76C64487E7EA9950BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7874A048E16844D02F0287E7EA99BE77_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7874A048E16844D02F0287E7EA99BE77" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value changes of derivative instruments, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7874A048E16844D02F0287E7EA99BE77" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7874A048E16844D02F0287E7EA99BE77" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7874A048E16844D02F0287E7EA99BE77" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income (expense), net </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpense_51D105E05C74DBF8A57C87E7EA9910DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920_totalLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net </link:label>
<link:label id="lab_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920_label_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920" xlink:to="lab_us-gaap_NonoperatingIncomeExpense_B0D6CA28F0FB97E8E8C587E7EA999920" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Loss before income taxes and investment losses </link:label>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1780168DD4CE61AD70FC87E7EA999A0B" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Income tax benefit (provision) </link:label>
<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE" xlink:to="lab_us-gaap_IncomeTaxExpenseBenefit_0D7125E4471B95B8E14A87E7EA993FBE" xlink:type="arc"/>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129_totalLabel_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Loss before investment losses </link:label>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129_label_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations, Before Investments in Investees, Extraordinary Items, Noncontrolling Interest, Net of Tax </link:label>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129_documentation_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Gain (loss) from continuing operations before investment losses. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" xlink:label="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:to="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_C9220A7060A5877EDC7187E7EA99A129" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Loss from investments in investees </link:label>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments_6F4D442B7DA0FB280B0A87E7EA99ED0D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281_totalLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net loss </link:label>
<link:label id="lab_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281_label_en-US" xlink:label="lab_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss), Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281" xlink:to="lab_us-gaap_ProfitLoss_7044ACBF605A0EC1111887E7EA999281" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Less: Net loss attributable to noncontrolling interests </link:label>
<link:label id="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A" xlink:to="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_47715935908FE7F9C8B987E7EA99D91A" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38_totalLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net loss attributable to common shareholders </link:label>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Available to Common Stockholders, Basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_23D4601618885E50E47887E7EA990F38" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Loss per share, basic and diluted: </link:label>
<link:label id="lab_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F" xlink:to="lab_us-gaap_EarningsPerShareAbstract_987171D3A8B14AF7821187E7EA99AA9F" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss per share </link:label>
<link:label id="lab_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share, Basic and Diluted </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98" xlink:to="lab_us-gaap_EarningsPerShareBasicAndDiluted_237205FC28AF26265E0887E7EA995A98" xlink:type="arc"/>
<link:label id="lab_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average common shares outstanding, basic and diluted </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Basic and Diluted </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE" xlink:to="lab_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_09F0E2BF17790431243A87E7EA9936DE" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9" xlink:to="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_7D7C6E2DEC63163435735F87950861C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities [Axis] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5E3D9FB88F6894B257BC5F879508E13D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities, Name [Domain] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2" xlink:to="lab_us-gaap_AntidilutiveSecuritiesNameDomain_8EF876C33497E4A942635F87950862B2" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockMember_F1FF3AE1F1A7BBACB7905F87950858E7_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_F1FF3AE1F1A7BBACB7905F87950858E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock investments, available for sale </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_F1FF3AE1F1A7BBACB7905F87950858E7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_F1FF3AE1F1A7BBACB7905F87950858E7" xlink:to="lab_us-gaap_CommonStockMember_F1FF3AE1F1A7BBACB7905F87950858E7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_AE74D120763B345D5F0F5F879508CADA" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F_verboseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Potential common shares </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6BA937319236A869A59E5F879508DF1F" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock warrant and common stock options exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Stock Options and Warrants Exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of common stock warrant and common stock options exercised. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:to="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_3C2B50C2FAC7A9B8E3D85F879508EA07" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock issued for stock warrant and stock options exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Stock Options and Warrants Exercised, Net of Shares Surrendered in Lieu of Cash Payment </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of common stock issued for stock warrant and stock options exercised. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:to="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_72EA837E5299BBEA2FA65F87950837E9" xlink:type="arc"/>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E_verboseLabel_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Shares surrendered in lieu of cash payment </link:label>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E_label_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Surrendered in Lieu of Cash Payment </link:label>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E_documentation_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares surrendered in lieu of cash payment. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SharesSurrenderedInLieuOfCashPayment" xlink:label="loc_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:to="lab_opk_SharesSurrenderedInLieuOfCashPayment_CEE2CCC5472583180B7F5F879508E98E" xlink:type="arc"/>
<link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8_verboseLabel_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES </link:label>
<link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8_label_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Significant Accounting Policies [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8" xlink:to="lab_us-gaap_SignificantAccountingPoliciesTextBlock_6243B74F3859C91130955F879522A9E8" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F" xlink:to="lab_us-gaap_LineOfCreditFacilityTable_7D296DF7AB1166FBEFCB8D934963504F" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24" xlink:to="lab_us-gaap_LineOfCreditFacilityAxis_E9426B3362AA7FCB43B28D9349632D24" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60" xlink:to="lab_us-gaap_LineOfCreditFacilityLenderDomain_18A23E49AACEEA2218C98D934964AB60" xlink:type="arc"/>
<link:label id="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D_terseLabel_en-US" xlink:label="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> JPMorgan Chase </link:label>
<link:label id="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D_label_en-US" xlink:label="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> JP Morgan Chase [Member] </link:label>
<link:label id="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D_documentation_en-US" xlink:label="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> JP Morgan Chase [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_JPMorganChaseMember" xlink:label="loc_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:to="lab_opk_JPMorganChaseMember_1CC4C1D794554A8983D88D934964DF9D" xlink:type="arc"/>
<link:label id="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636_verboseLabel_en-US" xlink:label="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Itau Bank </link:label>
<link:label id="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636_label_en-US" xlink:label="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Itau Bank [Member] </link:label>
<link:label id="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636_documentation_en-US" xlink:label="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Itau. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ItauBankMember" xlink:label="loc_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:to="lab_opk_ItauBankMember_A38B4FF83ED73305E4F08D9349649636" xlink:type="arc"/>
<link:label id="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0_verboseLabel_en-US" xlink:label="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Bank of Chile </link:label>
<link:label id="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0_label_en-US" xlink:label="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bank of Chile [Member] </link:label>
<link:label id="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0_documentation_en-US" xlink:label="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bank of Chile. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BankOfChileMember" xlink:label="loc_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:to="lab_opk_BankOfChileMember_B0E5E49D83CB6EDFF1978D9349649FE0" xlink:type="arc"/>
<link:label id="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A_verboseLabel_en-US" xlink:label="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BICE Bank </link:label>
<link:label id="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A_label_en-US" xlink:label="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bice Bank [Member] </link:label>
<link:label id="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A_documentation_en-US" xlink:label="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BICE Bank. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BiceBankMember" xlink:label="loc_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:to="lab_opk_BiceBankMember_17FF99AB6D48849663098D934964D96A" xlink:type="arc"/>
<link:label id="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195_verboseLabel_en-US" xlink:label="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BBVA Bank </link:label>
<link:label id="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195_label_en-US" xlink:label="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> BBVA Bank [Member] </link:label>
<link:label id="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195_documentation_en-US" xlink:label="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BBVA bank. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BbvaBankMember" xlink:label="loc_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:to="lab_opk_BbvaBankMember_DF2208416B9AF050D4E58D9349646195" xlink:type="arc"/>
<link:label id="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA_verboseLabel_en-US" xlink:label="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Security Bank </link:label>
<link:label id="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA_label_en-US" xlink:label="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Security [Member] </link:label>
<link:label id="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA_documentation_en-US" xlink:label="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Security. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SecurityMember" xlink:label="loc_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:to="lab_opk_SecurityMember_32BBAB770D2B4B5387258D9349640BDA" xlink:type="arc"/>
<link:label id="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A_verboseLabel_en-US" xlink:label="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estado Bank </link:label>
<link:label id="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A_label_en-US" xlink:label="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Estado Bank [Member] </link:label>
<link:label id="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A_documentation_en-US" xlink:label="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estado bank. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EstadoBankMember" xlink:label="loc_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:to="lab_opk_EstadoBankMember_6DF9BE9EAA6D5D93C52F8D934964744A" xlink:type="arc"/>
<link:label id="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946_terseLabel_en-US" xlink:label="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Santander Bank </link:label>
<link:label id="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946_label_en-US" xlink:label="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Santander Bank [Member] </link:label>
<link:label id="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946_documentation_en-US" xlink:label="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> santander Bank. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_SantanderBankMember" xlink:label="loc_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:to="lab_opk_SantanderBankMember_F235C44D19E3B4B8C3818D9349649946" xlink:type="arc"/>
<link:label id="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3_terseLabel_en-US" xlink:label="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Scotiabank </link:label>
<link:label id="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3_label_en-US" xlink:label="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Scotiabank [Member] </link:label>
<link:label id="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3_documentation_en-US" xlink:label="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Scotiabank [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ScotiabankMember" xlink:label="loc_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:to="lab_opk_ScotiabankMember_FAB16360B53C24211C128D9349644AA3" xlink:type="arc"/>
<link:label id="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B_terseLabel_en-US" xlink:label="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corpbanca </link:label>
<link:label id="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B_label_en-US" xlink:label="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corpbanca1 [Member] </link:label>
<link:label id="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B_documentation_en-US" xlink:label="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Corpbanca1 [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_Corpbanca1Member" xlink:label="loc_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:to="lab_opk_Corpbanca1Member_4111141DD5A6622CE1C78D934964229B" xlink:type="arc"/>
<link:label id="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2_verboseLabel_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Banco Bilbao Vizcaya </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2_label_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bilbao Vizcaya Bank [Member] </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2_documentation_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bilbao vizcaya bank. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BilbaoVizcayaBankMember" xlink:label="loc_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:to="lab_opk_BilbaoVizcayaBankMember_E00A14E0E2C7654DEE1E8D9349645CB2" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B" xlink:to="lab_us-gaap_LineOfCreditFacilityLineItems_9EE5712D1F9006085F9A8D934964CD5B" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A_verboseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on borrowings at March 31, 2016 </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Interest Rate at Period End </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A" xlink:to="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_3538C73EB58EC33B27C18D934964881A" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit line capacity </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Maximum Borrowing Capacity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961" xlink:to="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_1BAE3183BCA9DEA7F4808D934964D961" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Outstanding </link:label>
<link:label id="lab_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD_label_en-US" xlink:label="lab_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD" xlink:to="lab_us-gaap_LineOfCredit_371DD85E75BFFABE19F38D9349641DCD" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> EARNINGS (LOSS) PER SHARE </link:label>
<link:label id="lab_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F" xlink:to="lab_us-gaap_EarningsPerShareTextBlock_3CC68EB0ACBBE8C56E005F879581936F" xlink:type="arc"/>
<link:label id="lab_us-gaap_SharePrice_13CD6F2FAEBC8248FE275F8794E80F0A_verboseLabel_en-US" xlink:label="lab_us-gaap_SharePrice_13CD6F2FAEBC8248FE275F8794E80F0A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Stock price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_13CD6F2FAEBC8248FE275F8794E80F0A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharePrice_13CD6F2FAEBC8248FE275F8794E80F0A" xlink:to="lab_us-gaap_SharePrice_13CD6F2FAEBC8248FE275F8794E80F0A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8C91A65D66AEDFFF477E5F8794E976EC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8C91A65D66AEDFFF477E5F8794E976EC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8C91A65D66AEDFFF477E5F8794E976EC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8C91A65D66AEDFFF477E5F8794E976EC" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8C91A65D66AEDFFF477E5F8794E976EC" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_46D3AD36FCB19D2418175F8794E98FFB_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_46D3AD36FCB19D2418175F8794E98FFB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_46D3AD36FCB19D2418175F8794E98FFB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_46D3AD36FCB19D2418175F8794E98FFB" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_46D3AD36FCB19D2418175F8794E98FFB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maturity date </link:label>
<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Maturity Date </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927" xlink:to="lab_us-gaap_DebtInstrumentMaturityDate_DEE09567BB7BE070A0275F8794E93927" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Risk-free interest rate </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Risk Free Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD" xlink:to="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_C2D8BFE82D5DFD941A5E5F8794E9FAFD" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated stock volatility </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Expected Volatility Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597" xlink:to="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_2F0763C46994893822025F8794E9B597" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated credit spread </link:label>
<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541_label_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Entity Credit Risk </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsEntityCreditRisk" xlink:label="loc_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541" xlink:to="lab_us-gaap_FairValueInputsEntityCreditRisk_264074F2969D4FE6023C5F8794E96541" xlink:type="arc"/>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46_verboseLabel_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products </link:label>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46_label_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products [Member] </link:label>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46_documentation_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CurrentlyMarketedProductsMember" xlink:label="loc_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:to="lab_opk_CurrentlyMarketedProductsMember_A3095A5A3FC6D246FF647BF1C830BD46" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock received </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Number of Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_1377D53FF03A261F99F47BF1C8312665" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consideration transferred </link:label>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629" xlink:to="lab_us-gaap_BusinessCombinationConsiderationTransferred1_E5745F2A92DBA43FB6977BF1C8318629" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquired entity share price </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Share Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionSharePrice" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3" xlink:to="lab_us-gaap_BusinessAcquisitionSharePrice_2948B32C8854EC74A4DC7BF1C83197A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_A1D42440141EBF76C9627BF1C8318B88_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_A1D42440141EBF76C9627BF1C8318B88" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_A1D42440141EBF76C9627BF1C8318B88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_A1D42440141EBF76C9627BF1C8318B88" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_A1D42440141EBF76C9627BF1C8318B88" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Purchase accounting adjustments </link:label>
<link:label id="lab_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49_label_en-US" xlink:label="lab_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Purchase Accounting Adjustments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillPurchaseAccountingAdjustments" xlink:label="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49" xlink:to="lab_us-gaap_GoodwillPurchaseAccountingAdjustments_E35EC5CBFB4BF6CFBF407BF1C8319A49" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Purchase price allocation adjustment, accrued expenses </link:label>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33_label_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Accrued Expenses </link:label>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33_documentation_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Accrued Expenses </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses" xlink:label="loc_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:to="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpenses_B8DE633793CE0E8EB7447BF1C8317E33" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Purchase price allocation adjustment, deferred tax liability </link:label>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E_label_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Deferred Tax Liability </link:label>
<link:label id="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E_documentation_en-US" xlink:label="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Deferred Tax Liability </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability" xlink:label="loc_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:to="lab_opk_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredTaxLiability_1B1D427438CD38ED7E377BF1C831E33E" xlink:type="arc"/>
<link:label id="lab_us-gaap_Revenues_5E0648CF8175AC7A5AD07BF1C8310B52_terseLabel_en-US" xlink:label="lab_us-gaap_Revenues_5E0648CF8175AC7A5AD07BF1C8310B52" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_5E0648CF8175AC7A5AD07BF1C8310B52" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Revenues_5E0648CF8175AC7A5AD07BF1C8310B52" xlink:to="lab_us-gaap_Revenues_5E0648CF8175AC7A5AD07BF1C8310B52" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:label id="lab_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7_label_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7" xlink:to="lab_us-gaap_NetIncomeLoss_7A52D209C0F32E1423DC7BF1C8317CB7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A_terseLabel_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Useful life </link:label>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A_label_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Acquired Finite-lived Intangible Assets, Weighted Average Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A" xlink:to="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_48E27C39657F4C2BFE597BF1C8312F4A" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ACQUISITIONS, INVESTMENTS AND LICENSES </link:label>
<link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2" xlink:to="lab_us-gaap_BusinessCombinationDisclosureTextBlock_1C4D2F5FD15BEB69A7895F8794DD30B2" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityAbstract_E95C6064A0E9BA4CC0C55F879500BAA7_label_en-US" xlink:label="lab_us-gaap_EquityAbstract_E95C6064A0E9BA4CC0C55F879500BAA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_E95C6064A0E9BA4CC0C55F879500BAA7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityAbstract_E95C6064A0E9BA4CC0C55F879500BAA7" xlink:to="lab_us-gaap_EquityAbstract_E95C6064A0E9BA4CC0C55F879500BAA7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in Accumulated Other Comprehensive Income (Loss), Net of Tax </link:label>
<link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9" xlink:to="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_8C9BE7B91B37848358DD5F8795007FC9" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Table] </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_5AC7F39AB16B2BB2083986EAFDBC5A9B" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7_terseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
<link:label id="lab_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7_label_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7" xlink:to="lab_us-gaap_StatementEquityComponentsAxis_5A5E0AEFA0A702ECC95B86EAFDBC86A7" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2_terseLabel_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Component [Domain] </link:label>
<link:label id="lab_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2_label_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Component [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2" xlink:to="lab_us-gaap_EquityComponentDomain_2000B61569924F5A29C286EAFDBC5CE2" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency </link:label>
<link:label id="lab_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F_label_en-US" xlink:label="lab_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Foreign Currency Adjustment Attributable to Parent [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F" xlink:to="lab_us-gaap_AccumulatedTranslationAdjustmentMember_3AF8B1ABD0CAC6F854F386EAFDBCEF5F" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized gain (loss) in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC_label_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Net Investment Gain (Loss) Attributable to Parent [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC" xlink:to="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_23F0CEB2A25182B5AC6086EAFDBC33BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA_terseLabel_en-US" xlink:label="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> AOCI </link:label>
<link:label id="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA_label_en-US" xlink:label="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> AOCI Including Portion Attributable to Noncontrolling Interest [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA" xlink:to="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_D898089BF86CBB4F02D886EAFDBC7DEA" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Line Items] </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_2B00895006FA32B6701E86EAFDBC8B05" xlink:type="arc"/>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104_terseLabel_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Net [Rollforward] </link:label>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104_label_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax [Roll Forward] </link:label>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104_documentation_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax [Roll Forward] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward" xlink:label="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:to="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B6466CAE54F9366F660F86EAFDBC6104" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_11EF6B112655DBB2CBC086EAFDBC136F_periodStartLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_11EF6B112655DBB2CBC086EAFDBC136F" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_11EF6B112655DBB2CBC086EAFDBC136F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_11EF6B112655DBB2CBC086EAFDBC136F" xlink:to="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_11EF6B112655DBB2CBC086EAFDBC136F" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income before reclassifications </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), before Reclassifications, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E0586863F69F5F59493586EAFDBCD289" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0FA959E9983BDEF55E2386EAFDBC1666_periodEndLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0FA959E9983BDEF55E2386EAFDBC1666" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending Balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0FA959E9983BDEF55E2386EAFDBC1666" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0FA959E9983BDEF55E2386EAFDBC1666" xlink:to="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0FA959E9983BDEF55E2386EAFDBC1666" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F_terseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investments, investment carrying value </link:label>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Excluding Variable Interes tEntity </link:label>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Excluding Variable Interes tEntity </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EquityMethodInvestmentExcludingVariableInterestEntity" xlink:label="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:to="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_73E97799C04FE138EE525F8794873D4F" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investment, underlying equity in net assets </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Underlying Equity in Net Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3" xlink:to="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_2147E8F587B714C25D145F87948780E3" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2_terseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest entity, equity method </link:label>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Variable Interest Entity </link:label>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Variable Interest Entity </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EquityMethodInvestmentVariableInterestEntity" xlink:label="loc_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:to="lab_opk_EquityMethodInvestmentVariableInterestEntity_4E2CC687CDC7D2C0FA355F879487E2E2" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Available for sale investments </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_6E4F9C36484A4E9A03175F87948767B9" xlink:type="arc"/>
<link:label id="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93_terseLabel_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Warrants and options </link:label>
<link:label id="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93_label_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Option and Warrant Investments </link:label>
<link:label id="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93_documentation_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Option and Warrant Investments </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockOptionandWarrantInvestments" xlink:label="loc_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:to="lab_opk_StockOptionandWarrantInvestments_F3A5DBFF705AE68AA07E5F879487BA93" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermInvestments_B13756231EEA78EF74C25F879487CCAC_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_B13756231EEA78EF74C25F879487CCAC" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total carrying value of investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_B13756231EEA78EF74C25F879487CCAC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermInvestments_B13756231EEA78EF74C25F879487CCAC" xlink:to="lab_us-gaap_LongTermInvestments_B13756231EEA78EF74C25F879487CCAC" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A_verboseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ACCUMULATED OTHER COMPREHENSIVE INCOME (LOSS) </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss) Note [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A" xlink:to="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_A6986B85222663AB05305F8794F68E9A" xlink:type="arc"/>
<link:label id="lab_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40_terseLabel_en-US" xlink:label="lab_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> In Process Research and Development </link:label>
<link:label id="lab_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40_label_en-US" xlink:label="lab_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> In Process Research and Development [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40" xlink:to="lab_us-gaap_InProcessResearchAndDevelopmentMember_E54717648B19BDA26B775F87958A7D40" xlink:type="arc"/>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_083A3FBBF1673332B7AF5F87958A3882_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_083A3FBBF1673332B7AF5F87958A3882" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer Relationships </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_083A3FBBF1673332B7AF5F87958A3882" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerRelationshipsMember_083A3FBBF1673332B7AF5F87958A3882" xlink:to="lab_us-gaap_CustomerRelationshipsMember_083A3FBBF1673332B7AF5F87958A3882" xlink:type="arc"/>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_FF5462F916CF3E2C7A385F87958A9689_terseLabel_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_FF5462F916CF3E2C7A385F87958A9689" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CurrentlyMarketedProductsMember" xlink:label="loc_opk_CurrentlyMarketedProductsMember_FF5462F916CF3E2C7A385F87958A9689" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CurrentlyMarketedProductsMember_FF5462F916CF3E2C7A385F87958A9689" xlink:to="lab_opk_CurrentlyMarketedProductsMember_FF5462F916CF3E2C7A385F87958A9689" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_753904FB4231F2D7A6BC5F87958B93A3_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_753904FB4231F2D7A6BC5F87958B93A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_753904FB4231F2D7A6BC5F87958B93A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_753904FB4231F2D7A6BC5F87958B93A3" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_753904FB4231F2D7A6BC5F87958B93A3" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8_negatedTerseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable and other liabilities </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable and Other Current Liabilities </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable and Other Current Liabilities </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_DEA622F4A3E46DD38EBB5F87958B3DE8" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_BB64668A956055EDC1C85F87958BF68C_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_BB64668A956055EDC1C85F87958BF68C" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_BB64668A956055EDC1C85F87958BF68C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_BB64668A956055EDC1C85F87958BF68C" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_BB64668A956055EDC1C85F87958BF68C" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A6FC44E96124C6BDA4035F87958B8924_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A6FC44E96124C6BDA4035F87958B8924" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A6FC44E96124C6BDA4035F87958B8924" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A6FC44E96124C6BDA4035F87958B8924" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A6FC44E96124C6BDA4035F87958B8924" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_81B0165DD89EAC8AA5C85F87958CD078_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_81B0165DD89EAC8AA5C85F87958CD078" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_81B0165DD89EAC8AA5C85F87958CD078" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_81B0165DD89EAC8AA5C85F87958CD078" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_81B0165DD89EAC8AA5C85F87958CD078" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083_verboseLabel_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COMMITMENTS AND CONTINGENCIES </link:label>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Commitments and Contingencies Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083" xlink:to="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_218B3A880018799126E55F8795B8B083" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337_terseLabel_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337_label_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337" xlink:to="lab_us-gaap_StatementBusinessSegmentsAxis_904D376869DB1E5188FF86EAFD6E5337" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B_label_en-US" xlink:label="lab_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B" xlink:to="lab_us-gaap_SegmentDomain_8A5772CED3B4BEF2F18386EAFD6EC52B" xlink:type="arc"/>
<link:label id="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE_terseLabel_en-US" xlink:label="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmaceutical </link:label>
<link:label id="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE_label_en-US" xlink:label="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:label id="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE_documentation_en-US" xlink:label="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:to="lab_opk_PharmaceuticalMember_7057DDA98DF8948DEC4E86EAFD6EA4FE" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405_verboseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:label id="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405_label_en-US" xlink:label="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Diagnostics [Member] </link:label>
<link:label id="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405_documentation_en-US" xlink:label="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Diagnostics. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:to="lab_opk_DiagnosticsMember_E5BCFF69C8D2EB287C7486EAFD6EA405" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating Segments </link:label>
<link:label id="lab_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E_label_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Segments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E" xlink:to="lab_us-gaap_OperatingSegmentsMember_464A99CD59792ECDDD9886EAFD6EEC0E" xlink:type="arc"/>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E_terseLabel_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate </link:label>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E_label_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corporate, Non-Segment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E" xlink:to="lab_us-gaap_CorporateNonSegmentMember_A056A33E9D2FB3B1ED0586EAFD6E5E0E" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C_terseLabel_en-US" xlink:label="lab_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reconciling Items </link:label>
<link:label id="lab_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C_label_en-US" xlink:label="lab_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reconciling Items [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaterialReconcilingItemsMember" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C" xlink:to="lab_us-gaap_MaterialReconcilingItemsMember_A4AAD3F071F8D7898DFA86EAFD6E441C" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7_terseLabel_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:label id="lab_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7_label_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7" xlink:to="lab_us-gaap_StatementGeographicalAxis_17A4BCCD5DD83BF985D086EAFD6FE3C7" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC_label_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC" xlink:to="lab_us-gaap_SegmentGeographicalDomain_E773389C1854F965DDCC86EAFD6FBECC" xlink:type="arc"/>
<link:label id="lab_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476_verboseLabel_en-US" xlink:label="lab_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> United States </link:label>
<link:label id="lab_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476_label_en-US" xlink:label="lab_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> UNITED STATES </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_US" xlink:label="loc_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476" xlink:to="lab_country_US_DAFD9DF075D4E6228B1E86EAFD6FA476" xlink:type="arc"/>
<link:label id="lab_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF_terseLabel_en-US" xlink:label="lab_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ireland </link:label>
<link:label id="lab_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF_label_en-US" xlink:label="lab_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> IRELAND </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_IE" xlink:label="loc_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF" xlink:to="lab_country_IE_CA3ADF0367055DFC7CB086EAFD6FD4FF" xlink:type="arc"/>
<link:label id="lab_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2_verboseLabel_en-US" xlink:label="lab_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Chile </link:label>
<link:label id="lab_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2_label_en-US" xlink:label="lab_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CHILE </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_CL" xlink:label="loc_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2" xlink:to="lab_country_CL_8E61E6BFD0A362C29E8786EAFD6F77A2" xlink:type="arc"/>
<link:label id="lab_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C_verboseLabel_en-US" xlink:label="lab_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Spain </link:label>
<link:label id="lab_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C_label_en-US" xlink:label="lab_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SPAIN </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_ES" xlink:label="loc_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C" xlink:to="lab_country_ES_A06CFD0E70FE7E64FD7286EAFD6FAD4C" xlink:type="arc"/>
<link:label id="lab_country_IL_19F84E05CC80E545F17086EAFD6F4CA5_verboseLabel_en-US" xlink:label="lab_country_IL_19F84E05CC80E545F17086EAFD6F4CA5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Israel </link:label>
<link:label id="lab_country_IL_19F84E05CC80E545F17086EAFD6F4CA5_label_en-US" xlink:label="lab_country_IL_19F84E05CC80E545F17086EAFD6F4CA5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ISRAEL </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_IL" xlink:label="loc_country_IL_19F84E05CC80E545F17086EAFD6F4CA5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IL_19F84E05CC80E545F17086EAFD6F4CA5" xlink:to="lab_country_IL_19F84E05CC80E545F17086EAFD6F4CA5" xlink:type="arc"/>
<link:label id="lab_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5_verboseLabel_en-US" xlink:label="lab_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mexico </link:label>
<link:label id="lab_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5_label_en-US" xlink:label="lab_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MEXICO </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_MX" xlink:label="loc_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5" xlink:to="lab_country_MX_FCD31EAABEFB4592133986EAFD6FE4B5" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_491B674C9C7DFAEB215086EAFD6F708B_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_491B674C9C7DFAEB215086EAFD6F708B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_491B674C9C7DFAEB215086EAFD6F708B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_491B674C9C7DFAEB215086EAFD6F708B" xlink:to="lab_us-gaap_SalesRevenueServicesNet_491B674C9C7DFAEB215086EAFD6F708B" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_F32195D62748CBF3B17F86EAFD6F10DF_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_F32195D62748CBF3B17F86EAFD6F10DF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_F32195D62748CBF3B17F86EAFD6F10DF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueGoodsNet_F32195D62748CBF3B17F86EAFD6F10DF" xlink:to="lab_us-gaap_SalesRevenueGoodsNet_F32195D62748CBF3B17F86EAFD6F10DF" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_7B0160F446FF6F060AC686EAFD6FA7C0_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_7B0160F446FF6F060AC686EAFD6FA7C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating (loss) income </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_7B0160F446FF6F060AC686EAFD6FA7C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingIncomeLoss_7B0160F446FF6F060AC686EAFD6FA7C0" xlink:to="lab_us-gaap_OperatingIncomeLoss_7B0160F446FF6F060AC686EAFD6FA7C0" xlink:type="arc"/>
<link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624_verboseLabel_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Depreciation and amortization </link:label>
<link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624_label_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Depreciation, Depletion and Amortization </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624" xlink:to="lab_us-gaap_DepreciationDepletionAndAmortization_DDDD7F64B3DA3711A9C286EAFD6FC624" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss from investment in investees </link:label>
<link:label id="lab_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5_label_en-US" xlink:label="lab_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5" xlink:to="lab_us-gaap_GainLossOnInvestments_6A28863615D659269DAD86EAFD70ADC5" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNet_527D33789CC5D0689FC886EAFD70B380_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_527D33789CC5D0689FC886EAFD70B380" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_527D33789CC5D0689FC886EAFD70B380" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNet_527D33789CC5D0689FC886EAFD70B380" xlink:to="lab_us-gaap_SalesRevenueNet_527D33789CC5D0689FC886EAFD70B380" xlink:type="arc"/>
<link:label id="lab_us-gaap_Assets_C3A7AD14D46497E82C6286EAFD70AEFD_terseLabel_en-US" xlink:label="lab_us-gaap_Assets_C3A7AD14D46497E82C6286EAFD70AEFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_C3A7AD14D46497E82C6286EAFD70AEFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_C3A7AD14D46497E82C6286EAFD70AEFD" xlink:to="lab_us-gaap_Assets_C3A7AD14D46497E82C6286EAFD70AEFD" xlink:type="arc"/>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821_terseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference [Member] </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821_documentation_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" xlink:label="loc_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:to="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_DCF0A55EC458DF6EC0985F879480E821" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mortgage notes and other debt payables </link:label>
<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA_label_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, by Current and Noncurrent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA" xlink:to="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_6E6A49F60AFA4A49E9505F87948019EA" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtCurrent_1E5C810706318040F09D5F879480CC0C_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_1E5C810706318040F09D5F879480CC0C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of notes payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_1E5C810706318040F09D5F879480CC0C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtCurrent_1E5C810706318040F09D5F879480CC0C" xlink:to="lab_us-gaap_LongTermDebtCurrent_1E5C810706318040F09D5F879480CC0C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities </link:label>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD_label_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Excluding Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD" xlink:to="lab_us-gaap_LongTermDebtNoncurrent_3A65323CBDA664CF05B65F87948089CD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_C7D3B7E634C08A8AF2A15F879480551F_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_C7D3B7E634C08A8AF2A15F879480551F" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_C7D3B7E634C08A8AF2A15F879480551F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_C7D3B7E634C08A8AF2A15F879480551F" xlink:to="lab_us-gaap_LongTermDebt_C7D3B7E634C08A8AF2A15F879480551F" xlink:type="arc"/>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5_verboseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BUSINESS AND ORGANIZATION </link:label>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A54EFA6871FDD5736EF75F8795EC3CD5" xlink:type="arc"/>
<link:label id="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6_label_en-US" xlink:label="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Compositions of Certain Financial Statement Captions [Abstract] </link:label>
<link:label id="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6_documentation_en-US" xlink:label="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Compositions of Certain Financial Statement Captions [Abstract] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" xlink:label="loc_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6" xlink:to="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_5615E6497674C1341C7696AE8AE898A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfGoodwillTable" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC" xlink:to="lab_us-gaap_ScheduleOfGoodwillTable_AF576E5E551A0435A11C96AE8AE887FC" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_3137270A8BF4E141A8A396AE8AE8DE5A_terseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_3137270A8BF4E141A8A396AE8AE8DE5A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_3137270A8BF4E141A8A396AE8AE8DE5A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_3137270A8BF4E141A8A396AE8AE8DE5A" xlink:to="lab_opk_DiagnosticsMember_3137270A8BF4E141A8A396AE8AE8DE5A" xlink:type="arc"/>
<link:label id="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC_terseLabel_en-US" xlink:label="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CURNA </link:label>
<link:label id="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC_label_en-US" xlink:label="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:label id="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC_documentation_en-US" xlink:label="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:to="lab_opk_CURNAMember_48E8EB331575C493478696AE8AE941DC" xlink:type="arc"/>
<link:label id="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158_terseLabel_en-US" xlink:label="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> FineTech </link:label>
<link:label id="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158_label_en-US" xlink:label="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> FineTech [Member] </link:label>
<link:label id="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158_documentation_en-US" xlink:label="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> FineTech. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:to="lab_opk_FineTechMember_05F94FC496D575CFB62296AE8AE9B158" xlink:type="arc"/>
<link:label id="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6_terseLabel_en-US" xlink:label="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6_label_en-US" xlink:label="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Chile [Member] </link:label>
<link:label id="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6_documentation_en-US" xlink:label="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Opko Chile. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OpkoChileMember" xlink:label="loc_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:to="lab_opk_OpkoChileMember_3E0C9B346FCE7E1A39B996AE8AE95DE6" xlink:type="arc"/>
<link:label id="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941_terseLabel_en-US" xlink:label="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Biologics </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941_label_en-US" xlink:label="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941_documentation_en-US" xlink:label="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:to="lab_opk_OPKOBiologicsMember_D12E605E258566E8767D96AE8AE9C941" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8_terseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8_label_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8_documentation_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:to="lab_opk_OPKOHealthEuropeMember_76C2DE0296834D46AB8296AE8AE948A8" xlink:type="arc"/>
<link:label id="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F_terseLabel_en-US" xlink:label="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F_label_en-US" xlink:label="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:label id="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F_documentation_en-US" xlink:label="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OPKORentalMember" xlink:label="loc_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:to="lab_opk_OPKORentalMember_F0528A5B00666948985C96AE8AE9B84F" xlink:type="arc"/>
<link:label id="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2_terseLabel_en-US" xlink:label="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics </link:label>
<link:label id="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2_label_en-US" xlink:label="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:label id="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2_documentation_en-US" xlink:label="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ClarosMember" xlink:label="loc_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:to="lab_opk_ClarosMember_17C45CA9F97524D4126996AE8AE955F2" xlink:type="arc"/>
<link:label id="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5_verboseLabel_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Lab </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5_label_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Opko Diagnostics [Member] </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5_documentation_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:to="lab_opk_OpkoDiagnosticsMember_7BB845F2ABFBA76A191696AE8AE996D5" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:label id="lab_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61_label_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillLineItems" xlink:label="loc_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61" xlink:to="lab_us-gaap_GoodwillLineItems_57FBBE8FB857F22775F496AE8AE91A61" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:label id="lab_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D_label_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillRollForward" xlink:label="loc_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D" xlink:to="lab_us-gaap_GoodwillRollForward_91483A9BF1468BB20F4796AE8AE9698D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_2128FE69C9CC163B4F2596AE8AE96ABE_periodStartLabel_en-US" xlink:label="lab_us-gaap_Goodwill_2128FE69C9CC163B4F2596AE8AE96ABE" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_2128FE69C9CC163B4F2596AE8AE96ABE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_2128FE69C9CC163B4F2596AE8AE96ABE" xlink:to="lab_us-gaap_Goodwill_2128FE69C9CC163B4F2596AE8AE96ABE" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign exchange </link:label>
<link:label id="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D_label_en-US" xlink:label="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Foreign Currency Translation Gain (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D" xlink:to="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_29C18A52A93632932F2896B1EE2A273D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_B53C4D64600C947096EC96AE8AE979A0_periodEndLabel_en-US" xlink:label="lab_us-gaap_Goodwill_B53C4D64600C947096EC96AE8AE979A0" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_B53C4D64600C947096EC96AE8AE979A0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_B53C4D64600C947096EC96AE8AE979A0" xlink:to="lab_us-gaap_Goodwill_B53C4D64600C947096EC96AE8AE979A0" xlink:type="arc"/>
<link:label id="lab_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679_label_en-US" xlink:label="lab_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document and Entity Information [Abstract] </link:label>
<link:label id="lab_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679_documentation_en-US" xlink:label="lab_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Document and Entity Information [Abstract] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DocumentAndEntityInformationAbstract" xlink:label="loc_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679" xlink:to="lab_opk_DocumentAndEntityInformationAbstract_133F43C4F0260074020C5F8794CFD679" xlink:type="arc"/>
<link:label id="lab_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Registrant Name </link:label>
<link:label id="lab_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C_label_en-US" xlink:label="lab_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Registrant Name </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C" xlink:to="lab_dei_EntityRegistrantName_0FEC606BC5AAC21408C65F8794CF411C" xlink:type="arc"/>
<link:label id="lab_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Central Index Key </link:label>
<link:label id="lab_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Central Index Key </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15" xlink:to="lab_dei_EntityCentralIndexKey_9F239D25C5219F5D5E0E5F8794CFAF15" xlink:type="arc"/>
<link:label id="lab_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546_terseLabel_en-US" xlink:label="lab_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Type </link:label>
<link:label id="lab_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546_label_en-US" xlink:label="lab_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Type </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546" xlink:to="lab_dei_DocumentType_DBA09820176DD53812BF5F8794CF0546" xlink:type="arc"/>
<link:label id="lab_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Period End Date </link:label>
<link:label id="lab_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF_label_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Period End Date </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF" xlink:to="lab_dei_DocumentPeriodEndDate_E1518560CD72826633D25F8794CFE9BF" xlink:type="arc"/>
<link:label id="lab_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amendment Flag </link:label>
<link:label id="lab_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917_label_en-US" xlink:label="lab_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amendment Flag </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917" xlink:to="lab_dei_AmendmentFlag_52BA62767F57AE8BF8585F8794CFA917" xlink:type="arc"/>
<link:label id="lab_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Fiscal Year Focus </link:label>
<link:label id="lab_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997_label_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Fiscal Year Focus </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997" xlink:to="lab_dei_DocumentFiscalYearFocus_FE11DD614BBD966B72555F8794CFD997" xlink:type="arc"/>
<link:label id="lab_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Fiscal Period Focus </link:label>
<link:label id="lab_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66_label_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Fiscal Period Focus </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66" xlink:to="lab_dei_DocumentFiscalPeriodFocus_CCAE01ED7B7F6E69ACBB5F8794CF8A66" xlink:type="arc"/>
<link:label id="lab_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0_terseLabel_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current Fiscal Year End Date </link:label>
<link:label id="lab_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0_label_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Current Fiscal Year End Date </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0" xlink:to="lab_dei_CurrentFiscalYearEndDate_BD85F5F4629AEB4BF2275F8794CF05C0" xlink:type="arc"/>
<link:label id="lab_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6_terseLabel_en-US" xlink:label="lab_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Filer Category </link:label>
<link:label id="lab_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6_label_en-US" xlink:label="lab_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Filer Category </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6" xlink:to="lab_dei_EntityFilerCategory_89440BBDA59B6202463E5F8794CF4BE6" xlink:type="arc"/>
<link:label id="lab_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:label id="lab_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43" xlink:to="lab_dei_EntityCommonStockSharesOutstanding_EC30A8C36B8F5B4DAE5A5F8794CFAE43" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Investments Classified as Available for Sale and Carried at Fair Value </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities Reconciliation [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_902EA1FF46CEDEB402B15F879505C986" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis </link:label>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD" xlink:to="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_56390E5D9732CAA36A1B5F87950560BD" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> The Carrying Amount and Estimated Fair Value of Our Long-term Debt </link:label>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9_label_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9" xlink:to="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_1D6D3EFE9AC3A1B461D05F879505CFF9" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7_verboseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Reconciliation of the Beginning and Ending Balances of Level 3 Assets and Liabilities </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured On Recurring Basis, Unobservable Input Reconciliation [Table Text Block] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Reconciles beginning and ending balances of level three assets and liabilities. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_32B50A8D0BAD1B06859F5F87950561B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Operations and Assets for Operating Segments and Geographic Information </link:label>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7_label_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7" xlink:to="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_2A2DA72871EFE70607795F8795CEF9C7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_DE7ADD0340259D2F276B8D93499970B1" xlink:type="arc"/>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA_terseLabel_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. </link:label>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA_label_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. [Member] </link:label>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA_documentation_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_NonInvasiveMonitoringSystemsInc.Member" xlink:label="loc_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:to="lab_opk_NonInvasiveMonitoringSystemsInc.Member_919A12CCC16F7C2A20A58D9349994FAA" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Line Items] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_206703F19A3018D5C35F8D93499A57ED" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total assets of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_216CB71EC37D0F4AA2368D93499A1FC5" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA_negatedLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_3ED4B213B931E3A69CA98D93499A9CCA" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Net losses of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Net Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_AF6F3B504774F2629F5C8D93499A0667" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Market value </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Quoted Market Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentQuotedMarketValue" xlink:label="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3" xlink:to="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_F6D5262C1A7F24AB788C8D93499A0EF3" xlink:type="arc"/>
<link:label id="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F_terseLabel_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of sales employees </link:label>
<link:label id="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F_label_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Sales Employees </link:label>
<link:label id="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F_documentation_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of Sales Employees </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_NumberofSalesEmployees" xlink:label="loc_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:to="lab_opk_NumberofSalesEmployees_5CD2B77EC479149E02678D910AB6C18F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Values and Presentation of Derivative Financial Instruments </link:label>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Derivative Instruments in Statement of Financial Position, Fair Value [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_C65FBC5350F5C2036AAE5F8794D326C0" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Derivative Instrument Losses and Gains Recorded </link:label>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_09C7C625D17D4A99E45C5F8794D353BB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> DERIVATIVE CONTRACTS </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments and Hedging Activities Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_6A512BF08665A51F52565F8795038BC4" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E_verboseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SEGMENTS </link:label>
<link:label id="lab_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E_label_en-US" xlink:label="lab_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingDisclosureTextBlock" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E" xlink:to="lab_us-gaap_SegmentReportingDisclosureTextBlock_9664AA51DF727F56230A5F8795A9A98E" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_DE56C91EB52B77175C1E788626C84542_label_en-US" xlink:label="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_DE56C91EB52B77175C1E788626C84542" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Comprehensive Income [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_DE56C91EB52B77175C1E788626C84542" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_DE56C91EB52B77175C1E788626C84542" xlink:to="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_DE56C91EB52B77175C1E788626C84542" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_F85D2B5C37A65BA156D0788626C88010_terseLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_F85D2B5C37A65BA156D0788626C88010" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_F85D2B5C37A65BA156D0788626C88010" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_F85D2B5C37A65BA156D0788626C88010" xlink:to="lab_us-gaap_ProfitLoss_F85D2B5C37A65BA156D0788626C88010" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income (loss), net of tax: </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E400581B697D2813062E788626C80954" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in foreign currency translation and other comprehensive income (loss) </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_F789E5017213FC4DDFD1788626C81363" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Available for sale investments: </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6" xlink:to="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_1CD0B05C26AAB5A5658A788626C879E6" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in unrealized gain (loss), net of tax </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_32D2CFB92892CFB7D5A1788626C824C7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Comprehensive loss </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_02CAB21C7CCC3A0A2D1C788626C89C3F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Less: Comprehensive loss attributable to noncontrolling interest </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_27CB0D714BEF4ED87520788626C859F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Comprehensive loss attributable to common shareholders </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTax_2D83033450E736EED0BD788626C995D2" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collateral [Axis] </link:label>
<link:label id="lab_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB_label_en-US" xlink:label="lab_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collateral [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollateralAxis" xlink:label="loc_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB" xlink:to="lab_us-gaap_CollateralAxis_8A9BDB77278A4010B5E88E2D5EA003CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collateral [Domain] </link:label>
<link:label id="lab_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4_label_en-US" xlink:label="lab_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collateral [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollateralDomain" xlink:label="loc_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4" xlink:to="lab_us-gaap_CollateralDomain_13D88024B7F6921EEDDB8E33EA5CF8A4" xlink:type="arc"/>
<link:label id="lab_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Securities Pledged as Collateral </link:label>
<link:label id="lab_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366_label_en-US" xlink:label="lab_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Securities Pledged as Collateral [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuritiesPledgedAsCollateralMember" xlink:label="loc_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366" xlink:to="lab_us-gaap_SecuritiesPledgedAsCollateralMember_10BA1E06C3FD108F34648E318D208366" xlink:type="arc"/>
<link:label id="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56_terseLabel_en-US" xlink:label="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Relative Core </link:label>
<link:label id="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56_label_en-US" xlink:label="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Relative Core [Member] </link:label>
<link:label id="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56_documentation_en-US" xlink:label="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Relative Core [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_RelativeCoreMember" xlink:label="loc_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:to="lab_opk_RelativeCoreMember_C2162163F1E8808507EB8E17C2193B56" xlink:type="arc"/>
<link:label id="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86_terseLabel_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock received </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86_label_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Received </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86_documentation_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Received </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockExchangeAgreementStockReceived" xlink:label="loc_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:to="lab_opk_StockExchangeAgreementStockReceived_5076AAB32DFDD3FA40FA8D934989DD86" xlink:type="arc"/>
<link:label id="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC_terseLabel_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock transferred </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC_label_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Transferred </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC_documentation_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Transferred </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockExchangeAgreementStockTransferred" xlink:label="loc_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:to="lab_opk_StockExchangeAgreementStockTransferred_2536711BF678C959F0518D93498974CC" xlink:type="arc"/>
<link:label id="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1_terseLabel_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock transferred, shares </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1_label_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Transferred, Shares </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1_documentation_en-US" xlink:label="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Transferred, Shares </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockExchangeAgreementStockTransferredShares" xlink:label="loc_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:to="lab_opk_StockExchangeAgreementStockTransferredShares_6817D0EA137E406724F78D93498954B1" xlink:type="arc"/>
<link:label id="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750_terseLabel_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock received, shares </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750_label_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Received, Shares </link:label>
<link:label id="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750_documentation_en-US" xlink:label="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Exchange Agreement, Stock Received, Shares </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockExchangeAgreementStockReceivedShares" xlink:label="loc_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:to="lab_opk_StockExchangeAgreementStockReceivedShares_78346A1D929B6527F7908D9349898750" xlink:type="arc"/>
<link:label id="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0_terseLabel_en-US" xlink:label="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payment for promissory note </link:label>
<link:label id="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0_label_en-US" xlink:label="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Origination of Notes Receivable from Related Parties </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OriginationOfNotesReceivableFromRelatedParties" xlink:label="loc_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0" xlink:to="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_A2F4958AF2C2576141DA8D9349897DC0" xlink:type="arc"/>
<link:label id="lab_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265_terseLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Promissory note receivable </link:label>
<link:label id="lab_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265_label_en-US" xlink:label="lab_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Receivable, Related Parties </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotesReceivableRelatedParties" xlink:label="loc_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265" xlink:to="lab_us-gaap_NotesReceivableRelatedParties_19E88E391605900BB0BC8E17C1B4A265" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockSharesIssued_40EA9731F4EED486095A8E32CAEB4651_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_40EA9731F4EED486095A8E32CAEB4651" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock, shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_40EA9731F4EED486095A8E32CAEB4651" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesIssued_40EA9731F4EED486095A8E32CAEB4651" xlink:to="lab_us-gaap_CommonStockSharesIssued_40EA9731F4EED486095A8E32CAEB4651" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1" xlink:to="lab_us-gaap_FairValueByMeasurementFrequencyAxis_37DA6737F381649F50055F879529E9C1" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619" xlink:to="lab_us-gaap_FairValueMeasurementFrequencyDomain_8F9688F96A3D3ACFD2245F8795299619" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurements, Recurring </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurements, Recurring [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED" xlink:to="lab_us-gaap_FairValueMeasurementsRecurringMember_E60C6BBD2F3A4E84AF575F879529C0ED" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Asset Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0_label_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Asset Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0" xlink:to="lab_us-gaap_FairValueByAssetClassAxis_A88D18528F9049B1B6005F87952ACEE0" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Asset Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Asset Class [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2A96164F3367FBA02F205F87952A431B" xlink:type="arc"/>
<link:label id="lab_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06_verboseLabel_en-US" xlink:label="lab_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Money market funds </link:label>
<link:label id="lab_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06_label_en-US" xlink:label="lab_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Money Market Funds [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06" xlink:to="lab_us-gaap_MoneyMarketFundsMember_611D9075EAFF6709611A5F87952ABF06" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock options/warrants </link:label>
<link:label id="lab_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt Securities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE" xlink:to="lab_us-gaap_ConvertibleDebtSecuritiesMember_D9198AFD7579A9C375AB5F87952AC5EE" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForwardContractsMember_88C432B18507F609631D5F87952AFB4F_verboseLabel_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_88C432B18507F609631D5F87952AFB4F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Forward Contracts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_88C432B18507F609631D5F87952AFB4F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForwardContractsMember_88C432B18507F609631D5F87952AFB4F" xlink:to="lab_us-gaap_ForwardContractsMember_88C432B18507F609631D5F87952AFB4F" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_A3C2ACF4B13AA36897935F87952A946C_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_A3C2ACF4B13AA36897935F87952A946C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_A3C2ACF4B13AA36897935F87952A946C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_A3C2ACF4B13AA36897935F87952A946C" xlink:to="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_A3C2ACF4B13AA36897935F87952A946C" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_96F4EDFF887589DA99505F87952AD04D_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_96F4EDFF887589DA99505F87952AD04D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Quoted prices in active markets for identical assets (Level 1) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_96F4EDFF887589DA99505F87952AD04D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member_96F4EDFF887589DA99505F87952AD04D" xlink:to="lab_us-gaap_FairValueInputsLevel1Member_96F4EDFF887589DA99505F87952AD04D" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_8C3527F20E2A603350105F87952BB03A_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_8C3527F20E2A603350105F87952BB03A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Significant other observable inputs (Level 2) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_8C3527F20E2A603350105F87952BB03A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member_8C3527F20E2A603350105F87952BB03A" xlink:to="lab_us-gaap_FairValueInputsLevel2Member_8C3527F20E2A603350105F87952BB03A" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_64D39B694F688C7FC9AD5F87952BE7B3_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_64D39B694F688C7FC9AD5F87952BE7B3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Significant unobservable inputs (Level 3) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_64D39B694F688C7FC9AD5F87952BE7B3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member_64D39B694F688C7FC9AD5F87952BE7B3" xlink:to="lab_us-gaap_FairValueInputsLevel3Member_64D39B694F688C7FC9AD5F87952BE7B3" xlink:type="arc"/>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Assets: </link:label>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial Instruments, Financial Assets, Balance Sheet Groupings [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6" xlink:to="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_6BFB01C8D2BC696C437A5F87952BB4B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7" xlink:to="lab_us-gaap_AssetsFairValueDisclosure_522FDAEF6F5D0C712CF25F87952B51C7" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Fair Value Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_214DCFB5B00FA51B2FB45F87952BAA03" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial and Nonfinancial Liabilities, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure_ED216542B4F26AB46B6A5F87952B1A7E" xlink:type="arc"/>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2_verboseLabel_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Composition of Certain Financial Statement Captions </link:label>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2_label_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Composition of Certain Financial Statement Captions [Table Text Block] </link:label>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2_documentation_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Composition of certain financial statement captions. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" xlink:label="loc_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:to="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_85431E899F192BD809F15F8795C01CE2" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Changes in Goodwill </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock" xlink:label="loc_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F" xlink:to="lab_us-gaap_ScheduleOfGoodwillTextBlock_B78B5607945561BD39DE5F8795C0454F" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisitions by Unique Description [Axis] </link:label>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F_label_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisitions by Unique Description [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F" xlink:to="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_ED3715F017864ABD7C9F87EC1D0F369F" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F_label_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNameDomain" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F" xlink:to="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_FC3F8DB5576395EA4DCB87EC1D154A0F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock Conversion Description [Axis] </link:label>
<link:label id="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Conversion Description [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D" xlink:to="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_8A0F29301ECF46445A1287E7EA67294D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Name [Domain] </link:label>
<link:label id="lab_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66" xlink:to="lab_us-gaap_ConversionOfStockNameDomain_25562406B2513DCA3D9687E7EA67AE66" xlink:type="arc"/>
<link:label id="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91_terseLabel_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes </link:label>
<link:label id="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91_label_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Senior Notes [Member] </link:label>
<link:label id="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91_documentation_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Conversion of Senior Notes [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ConversionofSeniorNotesMember" xlink:label="loc_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:to="lab_opk_ConversionofSeniorNotesMember_FAD51E0A91CA93D555DE87E7EA670D91" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from operating activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_764924E6217F7413FAAB87E7EA67B713" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_537A9869359E031E322C87E7EA67D227_verboseLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_537A9869359E031E322C87E7EA67D227" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Net loss </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_537A9869359E031E322C87E7EA67D227" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_537A9869359E031E322C87E7EA67D227" xlink:to="lab_us-gaap_ProfitLoss_537A9869359E031E322C87E7EA67D227" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Adjustments to reconcile net loss to net cash used in operating activities: </link:label>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83_label_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83" xlink:to="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_349172EB3F4F702048A487E7EA674D83" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F_verboseLabel_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash interest </link:label>
<link:label id="lab_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F_label_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Paid-in-Kind Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaidInKindInterest" xlink:label="loc_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F" xlink:to="lab_us-gaap_PaidInKindInterest_AF1C28AFF7B7F677BC8D87E7EA68D30F" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_CF7D06F10E9E987426C887E7EA68C6B7_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_CF7D06F10E9E987426C887E7EA68C6B7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of deferred financing costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_CF7D06F10E9E987426C887E7EA68C6B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_CF7D06F10E9E987426C887E7EA68C6B7" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_CF7D06F10E9E987426C887E7EA68C6B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_8BB23BA1E6FFDDFAF81787E7EA68117B_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_8BB23BA1E6FFDDFAF81787E7EA68117B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Losses from investments in investees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_8BB23BA1E6FFDDFAF81787E7EA68117B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments_8BB23BA1E6FFDDFAF81787E7EA68117B" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments_8BB23BA1E6FFDDFAF81787E7EA68117B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_C1C69E7FC4FB1BDD0BBD87E7EA68FE1E_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_C1C69E7FC4FB1BDD0BBD87E7EA68FE1E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation – employees and non-employees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_C1C69E7FC4FB1BDD0BBD87E7EA68FE1E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_C1C69E7FC4FB1BDD0BBD87E7EA68FE1E" xlink:to="lab_us-gaap_ShareBasedCompensation_C1C69E7FC4FB1BDD0BBD87E7EA68FE1E" xlink:type="arc"/>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D_negatedLabel_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Revenue from receipt of equity </link:label>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D_label_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Receipt of Equity </link:label>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D_documentation_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue from receipt of equity. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_RevenueFromReceiptOfEquity" xlink:label="loc_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:to="lab_opk_RevenueFromReceiptOfEquity_D00779896A400A75D45F87E7EA686D3D" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Realized gain on sale of equity securities </link:label>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1_label_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Sale of Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1" xlink:to="lab_us-gaap_GainLossOnSaleOfInvestments_9F8116D3B75F45EC42A587E7EA68C3F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F_negatedLabel_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> (Gain) loss on conversion of 3.00% convertible senior notes </link:label>
<link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F_label_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Extinguishment of Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F" xlink:to="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_1FD80C21823C0F275E5587E7EA68A54F" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_C6D24AF0CEACC153516887E7EA68AA86_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_C6D24AF0CEACC153516887E7EA68AA86" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of derivative instruments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_C6D24AF0CEACC153516887E7EA68AA86" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_C6D24AF0CEACC153516887E7EA68AA86" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_C6D24AF0CEACC153516887E7EA68AA86" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_F766AAA8DBC22A6B3BBC87E7EA68BF18_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_F766AAA8DBC22A6B3BBC87E7EA68BF18" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_F766AAA8DBC22A6B3BBC87E7EA68BF18" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_F766AAA8DBC22A6B3BBC87E7EA68BF18" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_F766AAA8DBC22A6B3BBC87E7EA68BF18" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred income tax (benefit) provision </link:label>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003" xlink:to="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_49A9D724B9210460266B87E7EA686003" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in assets and liabilities, net of the effects of acquisitions: </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Operating Capital [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA" xlink:to="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_DFA9D3140BC8449131CD87E7EA68A0AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_A7E5ACDF49378BF1585287E7EA68048A" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Inventory </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Inventories </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50" xlink:to="lab_us-gaap_IncreaseDecreaseInInventories_5FE4162BC5262A3A7BDF87E7EA694F50" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Prepaid Expense and Other Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0" xlink:to="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_F7E1B0C4C7B60E5AB9D087E7EA69E4C0" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Other Operating Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A" xlink:to="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_3ACBB47CF9EC6D8F317A87E7EA69697A" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsPayable_208F469EEC7C3429A1AB87E7EA69ABD0" xlink:type="arc"/>
<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F_terseLabel_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency measurement </link:label>
<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F_label_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Foreign Currency Measurement </link:label>
<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F_documentation_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Foreign Currency Measurement </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_IncreaseDecreaseinForeignCurrencyMeasurement" xlink:label="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:to="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_ADB56E894B4EB40FA70D87E7EA69B57F" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174" xlink:to="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_65816288DCA6C28F779987E7EA691174" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses and other liabilities </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accrued Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0" xlink:to="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_A0DA891DCF628A81C37B87E7EA690EA0" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by (used in) operating activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_CB3DCB582C765A6BCC9F87E7EA69F3B9" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from investing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A106E58D472260F59B4887E7EA690463" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Investments in investees </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18" xlink:to="lab_us-gaap_PaymentsToAcquireInvestments_ADF3AC951F2F38528B3B87E7EA696B18" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Capital expenditures </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Productive Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0" xlink:to="lab_us-gaap_PaymentsToAcquireProductiveAssets_8AE45740E9F6934D379C87E7EA696AC0" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash used in investing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_E9AFC80664CE3295C8E787E7EA69A783" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from financing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BE084B3C2459F132C8DF87E7EA69F462" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from the exercise of Common Stock options and warrants </link:label>
<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Issuance or Sale of Equity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12" xlink:to="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_A4F6032EB57E43052A7B87E7EA6F1C12" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash from non-controlling interest </link:label>
<link:label id="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551_label_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from (Payments to) Noncontrolling Interests </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromPaymentsToMinorityShareholders" xlink:label="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551" xlink:to="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_613AC609EF56C7FAC23F87E7EA6FC551" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Borrowings on lines of credit </link:label>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527" xlink:to="lab_us-gaap_ProceedsFromLinesOfCredit_846AEFFE0C0ACC77601687E7EA6F5527" xlink:type="arc"/>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Repayments of lines of credit </link:label>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Repayments of Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F" xlink:to="lab_us-gaap_RepaymentsOfLinesOfCredit_5FDE9D37C5EA30919AF487E7EA6FA62F" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by financing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_345CEA0FE8FF71B4DFC387E7EA6FD4DD" xlink:type="arc"/>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E_verboseLabel_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Effect of exchange rate on cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E_label_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effect of Exchange Rate on Cash and Cash Equivalents </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E" xlink:to="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_FAFB28CD527F46F15E7B87E7EA6FB57E" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B_totalLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net increase (decrease) in cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Period Increase (Decrease) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B" xlink:to="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6A2AA65FB8CC075FE37D87E7EA6F801B" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_A2D7831A4EF9F137A8D587E7EA6F7763_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_A2D7831A4EF9F137A8D587E7EA6F7763" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at beginning of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_A2D7831A4EF9F137A8D587E7EA6F7763" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_A2D7831A4EF9F137A8D587E7EA6F7763" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_A2D7831A4EF9F137A8D587E7EA6F7763" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_6E814AC7A1D191F086E587E7EA6F43BF_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_6E814AC7A1D191F086E587E7EA6F43BF" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at end of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6E814AC7A1D191F086E587E7EA6F43BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6E814AC7A1D191F086E587E7EA6F43BF" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_6E814AC7A1D191F086E587E7EA6F43BF" xlink:type="arc"/>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUPPLEMENTAL INFORMATION: </link:label>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097_label_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Cash Flow Information [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097" xlink:to="lab_us-gaap_SupplementalCashFlowInformationAbstract_28FB41507F57A9651D5887E7EA6F7097" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest paid </link:label>
<link:label id="lab_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4_label_en-US" xlink:label="lab_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Paid </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4" xlink:to="lab_us-gaap_InterestPaid_ABC2A134B17097CFE40787E7EA6FD7B4" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes paid, net </link:label>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Taxes Paid, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A" xlink:to="lab_us-gaap_IncomeTaxesPaidNet_27767192F268D1B6BCE387E7EA6F396A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3_verboseLabel_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash financing: </link:label>
<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3_label_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3" xlink:to="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_37127B51AC109063BBF487E7EA7003A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued upon conversion, amount </link:label>
<link:label id="lab_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Amount Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConversionOfStockAmountIssued1" xlink:label="loc_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C" xlink:to="lab_us-gaap_ConversionOfStockAmountIssued1_7D12752F06C6E2C959A187E7EA70583C" xlink:type="arc"/>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575_verboseLabel_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock options and warrants, surrendered in net exercise </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575_label_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock Warrants Net Exercised </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575_documentation_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Common stock warrants net exercised. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_CommonStockWarrantsNetExercised" xlink:label="loc_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:to="lab_opk_CommonStockWarrantsNetExercised_64980C5752A36887BA2D87E7EA70D575" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283_terseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Issuance of capital stock to acquire or contingent consideration settlement: </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" xlink:label="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:to="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_67B933CBBC1808251D4087ED05C4B283" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital stock issued </link:label>
<link:label id="lab_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164_label_en-US" xlink:label="lab_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164" xlink:to="lab_us-gaap_StockIssued1_E26B4CA11550660609EF87EC1C9D5164" xlink:type="arc"/>
<link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COMPOSITION OF CERTAIN FINANCIAL STATEMENT CAPTIONS </link:label>
<link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417_label_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Balance Sheet Disclosures [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417" xlink:to="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_830BF008438A54BE6EBA5F8794AF3417" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A_verboseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of Notes: </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Fair Value of Embedded Derivative, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_5B5390DE08DFC580A52F5F879484F00A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> With the embedded derivatives </link:label>
<link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3" xlink:to="lab_us-gaap_ConvertibleDebtFairValueDisclosures_6D6AA6AF691D054496595F87948444D3" xlink:type="arc"/>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E_verboseLabel_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Without the embedded derivatives </link:label>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E_label_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures, Excluding Embedded Derivative </link:label>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E_documentation_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures, Excluding Embedded Derivative. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" xlink:label="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:to="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_B526BFA3043A2671FEAE5F879484A38E" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_276E36682200BF27D82E5F8794844CBB_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_276E36682200BF27D82E5F8794844CBB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Estimated fair value of the embedded derivatives </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_276E36682200BF27D82E5F8794844CBB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_276E36682200BF27D82E5F8794844CBB" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_276E36682200BF27D82E5F8794844CBB" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:label id="lab_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96_label_en-US" xlink:label="lab_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96" xlink:to="lab_us-gaap_VariableRateAxis_37E72FD1880922769CE39666D495EF96" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:label id="lab_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8" xlink:to="lab_us-gaap_VariableRateDomain_36C8F6294A8C66DC5CEE9666D495D7C8" xlink:type="arc"/>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3_terseLabel_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR </link:label>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3_label_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3" xlink:to="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2A64206642038A476A0D9666D495ADD3" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_E90D5A587AB29417C3D29666D495055E" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR Thereafter </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LondonInterbankOfferedRateLIBORThereafterMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_A42726617F2CB84764219666D4957BD5" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_E94C0FC9209D349228229666D49587D2" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, Thereafter, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_6385DF634E892CB638439666D4952330" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:label id="lab_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90_label_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90" xlink:to="lab_us-gaap_CreditFacilityAxis_8DABFBA1A166913395D49666D4950F90" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:label id="lab_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D_label_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D" xlink:to="lab_us-gaap_CreditFacilityDomain_82F04BC1328F000F89089666D495862D" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A_terseLabel_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility </link:label>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A_label_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A" xlink:to="lab_us-gaap_RevolvingCreditFacilityMember_802A7FAD485658936AED9666D495481A" xlink:type="arc"/>
<link:label id="lab_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578_terseLabel_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Swingline </link:label>
<link:label id="lab_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578_label_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bridge Loan [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BridgeLoanMember" xlink:label="loc_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578" xlink:to="lab_us-gaap_BridgeLoanMember_C7167BA21A8BA8C832B79666D4955578" xlink:type="arc"/>
<link:label id="lab_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9_terseLabel_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Letter of Credit </link:label>
<link:label id="lab_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9_label_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Letter of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LetterOfCreditMember" xlink:label="loc_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9" xlink:to="lab_us-gaap_LetterOfCreditMember_B3D4DCDB3CE9AE562C0D9666D49588B9" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit </link:label>
<link:label id="lab_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997_label_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997" xlink:to="lab_us-gaap_LineOfCreditMember_C88CE1BE576DF88B835B9666D4964997" xlink:type="arc"/>
<link:label id="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313_terseLabel_en-US" xlink:label="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Credit Agreement </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313_label_en-US" xlink:label="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313_documentation_en-US" xlink:label="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_NewCreditAgreementMember" xlink:label="loc_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:to="lab_opk_NewCreditAgreementMember_9966872AB71E9472DB7C9666D4962313" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_9CB2BAED30B22BDD34A39666D496BFD3" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_DB0CC9AD4CA7AC3FA9EA9666D4969D26" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> On or after February 1, 2017 and before February 1, 2019 </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period One [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_6B8C707427AF7DCB84F49666D4969878" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_39DB201F3948A6E777459666D497B494_verboseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_39DB201F3948A6E777459666D497B494" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_39DB201F3948A6E777459666D497B494" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_39DB201F3948A6E777459666D497B494" xlink:to="lab_opk_OPKOHealthEuropeMember_39DB201F3948A6E777459666D497B494" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equivalent redemption price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption Price, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_AFCEECE0258DD2996B709666D497FE34" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96_verboseLabel_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of trading days applicable conversion price </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96_label_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold For Trading Days </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96_documentation_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold For Trading Days </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtInstrumentConvertibleThresholdForTradingDays" xlink:label="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:to="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_B5420F44A8D15CFA97869666D497AC96" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_E8B2AF530A72434FBA639666D497FD61_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_E8B2AF530A72434FBA639666D497FD61" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, conversion </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="loc_us-gaap_DebtConversionOriginalDebtAmount1_E8B2AF530A72434FBA639666D497FD61" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionOriginalDebtAmount1_E8B2AF530A72434FBA639666D497FD61" xlink:to="lab_us-gaap_DebtConversionOriginalDebtAmount1_E8B2AF530A72434FBA639666D497FD61" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Convertible debt, stock issued from conversion </link:label>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Converted Instrument, Shares Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F" xlink:to="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_919EE87CF9ACDFC0C9089666D4979F9F" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_8F7625A234A368BA64349666D4975C1C_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_8F7625A234A368BA64349666D4975C1C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_8F7625A234A368BA64349666D4975C1C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_8F7625A234A368BA64349666D4975C1C" xlink:to="lab_us-gaap_LongTermDebt_8F7625A234A368BA64349666D4975C1C" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain (loss) on embedded derivative </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Gain (Loss) on Embedded Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C" xlink:to="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0973FA47C8952B2DA0899666D498E44C" xlink:type="arc"/>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291_terseLabel_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Higher borrowing capacity option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291_label_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291_documentation_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" xlink:label="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:to="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_FC09E9662627E1A158EE9666D4981291" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Basis spread on variable rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Basis Spread on Variable Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C" xlink:to="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_C4821347529652858B589666D4984A7C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Commitment fee percentage </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Commitment Fee Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F" xlink:to="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_6AA25A6EEE7E5F602D799666D4984F4F" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net assets </link:label>
<link:label id="lab_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F" xlink:to="lab_us-gaap_StockholdersEquity_9CF5856BE1212FD5F5689666D4980E5F" xlink:type="arc"/>
<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets, Net (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7" xlink:to="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_8CDE32AC614331AB6D7A9666D498E3D7" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550_verboseLabel_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of financial institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550_label_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instruments, Number of Financial Institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550_documentation_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of financial institutions. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_DebtInstrumentsNumberofFinancialInstitutions" xlink:label="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:to="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_424129FCDC6E4D9EB5A19666D498C550" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124_terseLabel_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average interest rate </link:label>
<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124_label_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt, Weighted Average Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124" xlink:to="lab_us-gaap_DebtWeightedAverageInterestRate_806CFCC4EA4A60A9D85A9666D4986124" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest rates </link:label>
<link:label id="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1_label_en-US" xlink:label="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Percentage Bearing Variable Interest, Percentage Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1" xlink:to="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_6CFA400907AC6553FF9A9666D498EBD1" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) by Hedging Relationship, by Income Statement Location, by Derivative Instrument Risk [Table] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D" xlink:to="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_111D5AEF208E783C2AFA5F87949EC32D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF" xlink:to="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_1BE4A6831A57FDF7F4D25F87949ECBCF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative gain (loss) </link:label>
<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0_label_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Gain (Loss) on Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0" xlink:to="lab_us-gaap_DerivativeGainLossOnDerivativeNet_8D9D5F2333BAE0B3F43C5F87949E24B0" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCondensedFinancialStatementsTable" xlink:label="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A" xlink:to="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_B3175321F76021779A3C96F8584D780A" xlink:type="arc"/>
<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC_terseLabel_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Technologies </link:label>
<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC_label_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Technology-Based Intangible Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC" xlink:to="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_2D94E4546A8478FA943996F8584D69AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894_terseLabel_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Licenses </link:label>
<link:label id="lab_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894_label_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Licensing Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LicensingAgreementsMember" xlink:label="loc_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894" xlink:to="lab_us-gaap_LicensingAgreementsMember_B52570D283FA2095F86596F8584DE894" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97_terseLabel_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Covenants not to compete </link:label>
<link:label id="lab_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97_label_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncompete Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NoncompeteAgreementsMember" xlink:label="loc_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97" xlink:to="lab_us-gaap_NoncompeteAgreementsMember_CEB776A1FDE926FED18696F8584D7D97" xlink:type="arc"/>
<link:label id="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B_terseLabel_en-US" xlink:label="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product registrations </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B_label_en-US" xlink:label="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B_documentation_en-US" xlink:label="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_ProductRegistrationsMember" xlink:label="loc_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:to="lab_opk_ProductRegistrationsMember_BF220FD8339FA950319296F8584D2F2B" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9_label_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Intangible Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9" xlink:to="lab_us-gaap_OtherIntangibleAssetsMember_C4A92E95C0DD46AA5D1496F8584DA9A9" xlink:type="arc"/>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CondensedFinancialStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611" xlink:to="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_3FDD7FEC3FBAE14BD92C96F8584EB611" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableNetAbstract" xlink:label="loc_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A" xlink:to="lab_us-gaap_AccountsReceivableNetAbstract_B1A1182FCB61BC1F185E96F8584E534A" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_3C06077762D9DB2A160596F8584E3EE3_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_3C06077762D9DB2A160596F8584E3EE3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_3C06077762D9DB2A160596F8584E3EE3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableGrossCurrent_3C06077762D9DB2A160596F8584E3EE3" xlink:to="lab_us-gaap_AccountsReceivableGrossCurrent_3C06077762D9DB2A160596F8584E3EE3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_34E71D90B2694C08EE6F96F8584E5095_negatedLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_34E71D90B2694C08EE6F96F8584E5095" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: allowance for doubtful accounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_34E71D90B2694C08EE6F96F8584E5095" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_34E71D90B2694C08EE6F96F8584E5095" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_34E71D90B2694C08EE6F96F8584E5095" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_7379E30136195659C9EE96F8584E0FEA_totalLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_7379E30136195659C9EE96F8584E0FEA" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_7379E30136195659C9EE96F8584E0FEA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_7379E30136195659C9EE96F8584E0FEA" xlink:to="lab_us-gaap_AccountsReceivableNetCurrent_7379E30136195659C9EE96F8584E0FEA" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories, net </link:label>
<link:label id="lab_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C_label_en-US" xlink:label="lab_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C" xlink:to="lab_us-gaap_InventoryNetAbstract_8ECA03854EB3DC0D364F96F8584E9E6C" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3_terseLabel_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consumable supplies </link:label>
<link:label id="lab_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3_label_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Inventory, Supplies, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherInventorySupplies" xlink:label="loc_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3" xlink:to="lab_us-gaap_OtherInventorySupplies_FAD471D356B42AEF407A96F8584E3EE3" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Finished products </link:label>
<link:label id="lab_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC_label_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Finished Goods, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC" xlink:to="lab_us-gaap_InventoryFinishedGoods_F8BFAC953823412D1CAF96F8584E57BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Work in-process </link:label>
<link:label id="lab_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2_label_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Work in Process, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2" xlink:to="lab_us-gaap_InventoryWorkInProcess_85BCE8ABCCCA0DBC3BC096F8584EAFA2" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Raw materials </link:label>
<link:label id="lab_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3_label_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Raw Materials, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3" xlink:to="lab_us-gaap_InventoryRawMaterials_35F0737060DD8C3CB3B596F8584E84E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0_negatedLabel_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: inventory reserve </link:label>
<link:label id="lab_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0_label_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Valuation Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0" xlink:to="lab_us-gaap_InventoryValuationReserves_60693B9D3230DDF5C07796F8584E78A0" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNet_B89996C9DECBFA2B06CF96F8584E9E97_totalLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_B89996C9DECBFA2B06CF96F8584E9E97" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Inventory, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_B89996C9DECBFA2B06CF96F8584E9E97" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet_B89996C9DECBFA2B06CF96F8584E9E97" xlink:to="lab_us-gaap_InventoryNet_B89996C9DECBFA2B06CF96F8584E9E97" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_F19ED21521EA66F2710796F8584EC66C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other receivables </link:label>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C_label_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts and Other Receivables, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C" xlink:to="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_807F41C37E01AD52125E96F8584EE93C" xlink:type="arc"/>
<link:label id="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19_terseLabel_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Taxes recoverable </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19_label_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19_documentation_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_TaxesRecoverableCurrent" xlink:label="loc_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:to="lab_opk_TaxesRecoverableCurrent_6CC110DC68AC0976312196F8584EFE19" xlink:type="arc"/>
<link:label id="lab_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81_terseLabel_en-US" xlink:label="lab_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid supplies </link:label>
<link:label id="lab_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81_label_en-US" xlink:label="lab_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Supplies </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Supplies" xlink:label="loc_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81" xlink:to="lab_us-gaap_Supplies_E904B1BDD09E693CFDDC96F8584EBD81" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid insurance </link:label>
<link:label id="lab_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F_label_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Insurance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F" xlink:to="lab_us-gaap_PrepaidInsurance_71429CCDAF910A630D4A96F8584F7F6F" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665_label_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665" xlink:to="lab_us-gaap_OtherAssetsCurrent_9E59856E0E2A7159F51696F8584F7665" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1642145A958B6454CDEC96F8584FA6A1_totalLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1642145A958B6454CDEC96F8584FA6A1" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1642145A958B6454CDEC96F8584FA6A1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1642145A958B6454CDEC96F8584FA6A1" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1642145A958B6454CDEC96F8584FA6A1" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net: </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_013A28CF8DA03A14423E96F8584F54CD" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsGross_D839D37317D07BE8805696F8584F561D" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE_negatedLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: accumulated amortization </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Accumulated Amortization </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2F0559DED6C5F9887D7796F8584FD8CE" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_E392D65A0ACB4931E0B496F8584F0458_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_E392D65A0ACB4931E0B496F8584F0458" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_E392D65A0ACB4931E0B496F8584F0458" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_E392D65A0ACB4931E0B496F8584F0458" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet_E392D65A0ACB4931E0B496F8584F0458" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses: </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_DE0A473F2362C2AA895A96F8584FC00E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3_verboseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3" xlink:to="lab_us-gaap_DeferredRevenueCurrent_C6F142202B22F8EDE90B96F8584FFBF3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Employee benefits </link:label>
<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171_label_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Employee Benefits, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171" xlink:to="lab_us-gaap_AccruedEmployeeBenefitsCurrent_5471D0A4E1759B50025D96F8584F6171" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_6A225994FBF9E1654AA996F8584F8518" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Taxes payable </link:label>
<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B_label_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Income Taxes, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B" xlink:to="lab_us-gaap_AccruedIncomeTaxesCurrent_6A41271CFB86F4E6941296F8584F9F8B" xlink:type="arc"/>
<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases short-term </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeaseObligationsCurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6" xlink:to="lab_us-gaap_CapitalLeaseObligationsCurrent_C62D70C3F97527C1BE9096F8584F4FB6" xlink:type="arc"/>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C_verboseLabel_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Clinical trials </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C_label_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Clinical Trials, Current </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C_documentation_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accrued clinical trials. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_AccruedClinicalTrialsCurrent" xlink:label="loc_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:to="lab_opk_AccruedClinicalTrialsCurrent_EBC6D3CCC27BCBAE8F8096F8584FB59C" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636_label_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Deferred Acquisition Payments, Net of Discount, Current </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636_documentation_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Deferred acquisition payments net of discount. </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" xlink:label="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:to="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_87F2CE73172AFF6E979396F8584F8636" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Professional fees </link:label>
<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43_label_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Professional Fees, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43" xlink:to="lab_us-gaap_AccruedProfessionalFeesCurrent_DCC9CAEEFF32C102ECD296F8584F8C43" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360_label_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Accrued Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360" xlink:to="lab_us-gaap_OtherAccruedLiabilitiesCurrent_75B88363AB38260E4B3E96F8584FC360" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_AC76B8A1F70A749C3BCD96F8584F5E1E_totalLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_AC76B8A1F70A749C3BCD96F8584F5E1E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_AC76B8A1F70A749C3BCD96F8584F5E1E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_AC76B8A1F70A749C3BCD96F8584F5E1E" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrent_AC76B8A1F70A749C3BCD96F8584F5E1E" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities: </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Noncurrent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_8A01020FE45F5F6C323D96F8584FA26D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0" xlink:to="lab_us-gaap_DeferredRevenueNoncurrent_FFF7B1FFA00BAADFC3E296F8585012D0" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCredit_D1A113B66BAD26E4ED2296F85850133E_verboseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit_D1A113B66BAD26E4ED2296F85850133E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Line of credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_D1A113B66BAD26E4ED2296F85850133E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCredit_D1A113B66BAD26E4ED2296F85850133E" xlink:to="lab_us-gaap_LineOfCredit_D1A113B66BAD26E4ED2296F85850133E" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_C5004FA8270B2EFFB99596F8585091FD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_2B1CC10E61CC5EC8A78196F85850F97C_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_2B1CC10E61CC5EC8A78196F85850F97C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Mortgages and other debts payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_2B1CC10E61CC5EC8A78196F85850F97C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_2B1CC10E61CC5EC8A78196F85850F97C" xlink:to="lab_us-gaap_LongTermDebtNoncurrent_2B1CC10E61CC5EC8A78196F85850F97C" xlink:type="arc"/>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases long-term </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeaseObligationsNoncurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59" xlink:to="lab_us-gaap_CapitalLeaseObligationsNoncurrent_BA9044329B6FF038E10296F858500B59" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities and Deferred Revenue, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72" xlink:to="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_FE64E3BBB06315B96CF196F858505C72" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_30B2D88433CBE4EBFE4B96F85850DEEA_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent_30B2D88433CBE4EBFE4B96F85850DEEA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_30B2D88433CBE4EBFE4B96F85850DEEA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_30B2D88433CBE4EBFE4B96F85850DEEA" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrent_30B2D88433CBE4EBFE4B96F85850DEEA" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4" xlink:to="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_01BA5DD49AA5A7A583E086EAFE4603F4" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7" xlink:to="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_84264A6DE7C83F5C0B5B86EAFE4622A7" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss attributable to common shareholders </link:label>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39_label_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) Available to Common Stockholders </link:label>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) Available to Common Stockholders </link:label>
<link:loc xlink:href="opk-20160331.xsd#opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders" xlink:label="loc_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:to="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2F1B809E5D3A5C29E8F86EAFE461C39" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_7D0765ED67BE4004BEA95F87951FE5A2" xlink:type="arc"/>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Axis] </link:label>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_C248520DAC02DD3865DF5F87951F86F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Domain] </link:label>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_13377BF3E202F8FB46CA5F87951F4C71" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Line Items] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_22CBC7BBCAC6002682185F87952017E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF_totalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Amortized Cost </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Amortized Cost Basis </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_9795F4066500AF5289125F87952072CF" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gross unrealized gains in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_C20DD30EC7B1415288705F879520340B" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Gross unrealized losses in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_19C8BDE2B7DBCDE549EF5F8795203852" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B" xlink:to="lab_us-gaap_AvailableForSaleSecurities_A6D02CA32D72DE6F00F55F879520E41B" xlink:type="arc"/>
</link:labelLink>
</link:linkbase>

↑Top
Filing Submission 0000944809-16-000022   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Sun., Apr. 28, 10:51:20.2am ET