SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-K’ for 12/31/14 – ‘EX-101.DEF’

On:  Friday, 2/27/15, at 4:47pm ET   ·   For:  12/31/14   ·   Accession #:  944809-15-3   ·   File #:  1-33528

Previous ‘10-K’:  ‘10-K’ on 3/3/14 for 12/31/13   ·   Next:  ‘10-K/A’ on 4/30/15 for 12/31/14   ·   Latest:  ‘10-K’ on 3/1/24 for 12/31/23   ·   3 References:   

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 2/27/15  Opko Health, Inc.                 10-K       12/31/14  109:23M

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.36M 
 2: EX-10.23    Material Contract                                   HTML    483K 
 3: EX-21       Subsidiaries List                                   HTML     31K 
 4: EX-23.1     Consent of Experts or Counsel                       HTML     32K 
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     35K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     35K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     29K 
 8: EX-32.2     Certification -- §906 - SOA'02                      HTML     29K 
74: R1          Document and Entity Information                     HTML     57K 
59: R2          Consolidated Balance Sheets (Unaudited)             HTML    141K 
71: R3          Consolidated Balance Sheets (Unaudited)             HTML     39K 
                (Parenthetical)                                                  
78: R4          Consolidated Statements of Operations (Unaudited)   HTML    128K 
99: R5          Consolidated Statements of Comprehensive Loss       HTML     67K 
                (Unaudited)                                                      
62: R6          Consolidated Statements of Cash Flows (Unaudited)   HTML    251K 
70: R7          Condensed Consolidated Statements of Cash Flows     HTML     31K 
                (Unaudited) (Parenthetical)                                      
53: R8          Condensed Consolidated Statement of Equity          HTML    222K 
43: R9          Condensed Consolidated Statement of Shareholders'   HTML     42K 
                Equity (Unaudited) (Parenthetical)                               
101: R10         Business and Organization                           HTML     37K  
80: R11         Summary of Significant Accounting Policies          HTML     77K 
79: R12         Loss Per Share                                      HTML     36K 
86: R13         Acquisitions, Investments, and Licenses             HTML    140K 
87: R14         Composition of Certain Financial Statement          HTML    294K 
                Captions                                                         
84: R15         Debt                                                HTML    160K 
88: R16         Shareholders' Equity                                HTML     57K 
72: R17         Accumulated Other Comprehensive Income              HTML     67K 
75: R18         Equity-Based Compensation                           HTML     82K 
82: R19         Income Taxes                                        HTML    150K 
109: R20         Related Party Transactions                          HTML     58K  
95: R21         Employee Benefit Plans                              HTML     31K 
66: R22         Commitments and Contingencies                       HTML     41K 
81: R23         Strategic Alliances                                 HTML     38K 
68: R24         Leases                                              HTML     40K 
34: R25         Segments                                            HTML    138K 
96: R26         Fair Value Measurements                             HTML    225K 
105: R27         Derivative Contracts                                HTML    104K  
48: R28         Selected Quarterly Financial Data (Unaudited)       HTML     68K 
47: R29         Subsequent Events                                   HTML     30K 
51: R30         Summary of Significant Accounting Policies          HTML    146K 
                (Policies)                                                       
52: R31         Acquisitions, Investments, and Licenses (Tables)    HTML    112K 
54: R32         Composition of Certain Financial Statement          HTML    300K 
                Captions (Tables)                                                
23: R33         Debt (Tables)                                       HTML    156K 
93: R34         Shareholders' Equity (Tables)                       HTML     44K 
64: R35         Accumulated Other Comprehensive Income (Tables)     HTML     62K 
67: R36         Equity-Based Compensation (Tables)                  HTML     67K 
38: R37         Income Taxes (Tables)                               HTML    148K 
108: R38         Leases (Tables)                                     HTML     36K  
15: R39         Segments (Tables)                                   HTML    131K 
56: R40         Fair Value Measurements (Tables)                    HTML    223K 
98: R41         Derivative Contracts (Tables)                       HTML    104K 
36: R42         Selected Quarterly Financial Data (Unaudited)       HTML     67K 
                (Tables)                                                         
46: R43         Summary of Significant Accounting Policies          HTML    187K 
                (Details)                                                        
50: R44         Loss Per Share (Details)                            HTML     44K 
60: R45         Acquisitions, Investments, and Licenses - Textual   HTML    233K 
                (Details)                                                        
22: R46         Acquisitions, Investments, and Licenses - Summary   HTML     94K 
                of Assets Acquired and Liabilities Assumed                       
                (Details)                                                        
42: R47         Acquisitions, Investments, and Licenses - Summary   HTML     42K 
                of Pro Forma Results (Details)                                   
17: R48         Acquisitions, Investments, and Licenses - Summary   HTML     45K 
                of Investments (Details)                                         
97: R49         Acquisitions, Investments, and Licenses - Schedule  HTML    112K 
                of Consolidated Assets and Non-Recourse                          
                Liabilities (Details)                                            
35: R50         Composition of Certain Financial Statement          HTML    203K 
                Captions (Details)                                               
94: R51         Composition of Certain Financial Statement          HTML    167K 
                Captions (Details 1)                                             
39: R52         Composition of Certain Financial Statement          HTML     61K 
                Captions (Details 2)                                             
57: R53         Composition of Certain Financial Statement          HTML    120K 
                Captions (Details 3)                                             
16: R54         Debt - Notes (Details)                              HTML     90K 
20: R55         Debt - Inputs Used In Lattice Model (Details)       HTML     63K 
49: R56         Debt - Fair Value Of Embedded Derivatives           HTML     39K 
                (Details)                                                        
27: R57         Debt - Lines Of Credit (Details)                    HTML     86K 
102: R58         Debt - Mortgage Notes And Other Debt (Details)      HTML     43K  
63: R59         Debt - Textual (Details)                            HTML    130K 
85: R60         Shareholders' Equity (Details)                      HTML     52K 
41: R61         Shareholders' Equity (Details Textual)              HTML     92K 
44: R62         Accumulated Other Comprehensive Income (Details)    HTML     61K 
92: R63         Accumulated Other Comprehensive Income (Details     HTML     40K 
                Textual)                                                         
89: R64         Equity-Based Compensation (Details Textual)         HTML     90K 
65: R65         Equity-Based Compensation (Details)                 HTML     55K 
91: R66         Equity-Based Compensation (Details 1)               HTML     89K 
40: R67         Income Taxes (Details)                              HTML     69K 
69: R68         Income Taxes (Details 1)                            HTML     84K 
104: R69         Income Taxes (Details 2)                            HTML     44K  
19: R70         Income Taxes (Details 3)                            HTML     60K 
33: R71         Income Taxes (Details 4)                            HTML     38K 
58: R72         Income Taxes (Details 5)                            HTML     35K 
25: R73         Income Taxes (Details Textual)                      HTML     81K 
107: R74         Related Party Transactions - Textual (Details)      HTML    470K  
37: R75         Employee Benefit Plans (Details)                    HTML     37K 
28: R76         Commitments and Contingencies (Details)             HTML     53K 
32: R77         Strategic Alliances Strategic Alliances (Details)   HTML     71K 
21: R78         Leases (Details Textual)                            HTML     30K 
24: R79         Leases (Details)                                    HTML     48K 
76: R80         Segments (Details Textual)                          HTML     61K 
30: R81         Segments (Details)                                  HTML    154K 
103: R82         Fair Value Measurements - Summary Of Investments    HTML     57K  
                (Details)                                                        
55: R83         Fair Value Measurements - Assets And Liabilities    HTML     98K 
                Measured At Fair Value (Details)                                 
83: R84         Fair Value Measurements - Notes (Details)           HTML     33K 
90: R85         Fair Value Measurements - Level 3 Reconciliation    HTML     75K 
                (Details)                                                        
29: R86         Fair Value Measurements - Textual (Details)         HTML     54K 
31: R87         Derivative Contracts (Details)                      HTML     47K 
100: R88         Derivative Contracts (Details 1)                    HTML     40K  
26: R89         Derivative Contracts (Details 2)                    HTML     86K 
77: R90         Selected Quarterly Financial Data (Unaudited)       HTML     55K 
                (Details)                                                        
73: R91         Subsequent Events Subsequent Events (Details)       HTML     30K 
106: XML         IDEA XML File -- Filing Summary                      XML    172K  
18: EXCEL       IDEA Workbook of Financial Reports                  XLSX    407K 
45: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   3.59M 
 9: EX-101.INS  XBRL Instance -- opk-20141231                        XML   5.27M 
11: EX-101.CAL  XBRL Calculations -- opk-20141231_cal                XML    320K 
12: EX-101.DEF  XBRL Definitions -- opk-20141231_def                 XML   1.47M 
13: EX-101.LAB  XBRL Labels -- opk-20141231_lab                      XML   3.20M 
14: EX-101.PRE  XBRL Presentations -- opk-20141231_pre               XML   1.92M 
10: EX-101.SCH  XBRL Schema -- opk-20141231                          XSD    297K 
61: ZIP         XBRL Zipped Folder -- 0000944809-15-000003-xbrl      Zip    468K

‘EX-101.DEF’   —   XBRL Definitions — opk-20141231_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva, formerly WebFilings -->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncome" xlink:href="opk-20141231.xsd#AccumulatedOtherComprehensiveIncome" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeDetails" xlink:href="opk-20141231.xsd#AccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeDetailsTextual" xlink:href="opk-20141231.xsd#AccumulatedOtherComprehensiveIncomeDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeTables" xlink:href="opk-20141231.xsd#AccumulatedOtherComprehensiveIncomeTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicenses" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicenses" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesScheduleOfConsolidatedAssetsAndNonRecourseLiabilitiesDetails" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesScheduleOfConsolidatedAssetsAndNonRecourseLiabilitiesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesSummaryOfAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfInvestmentsDetails" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesSummaryOfInvestmentsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfProFormaResultsDetails" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesSummaryOfProFormaResultsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTextualDetails" xlink:href="opk-20141231.xsd#AcquisitionsInvestmentsAndLicensesTextualDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/BusinessAndOrganization" xlink:href="opk-20141231.xsd#BusinessAndOrganization" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CommitmentsAndContingencies" xlink:href="opk-20141231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CommitmentsAndContingenciesDetails" xlink:href="opk-20141231.xsd#CommitmentsAndContingenciesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptions" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptions" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptionsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails1" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptionsDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails2" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptionsDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails3" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptionsDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsTables" xlink:href="opk-20141231.xsd#CompositionOfCertainFinancialStatementCaptionsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CondensedConsolidatedStatementOfEquity" xlink:href="opk-20141231.xsd#CondensedConsolidatedStatementOfEquity" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CondensedConsolidatedStatementOfShareholdersEquityUnauditedParenthetical" xlink:href="opk-20141231.xsd#CondensedConsolidatedStatementOfShareholdersEquityUnauditedParenthetical" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/CondensedConsolidatedStatementsOfCashFlowsUnauditedParenthetical" xlink:href="opk-20141231.xsd#CondensedConsolidatedStatementsOfCashFlowsUnauditedParenthetical" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ConsolidatedBalanceSheetsUnaudited" xlink:href="opk-20141231.xsd#ConsolidatedBalanceSheetsUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ConsolidatedBalanceSheetsUnauditedParenthetical" xlink:href="opk-20141231.xsd#ConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="opk-20141231.xsd#ConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:href="opk-20141231.xsd#ConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsOfOperationsUnaudited" xlink:href="opk-20141231.xsd#ConsolidatedStatementsOfOperationsUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/Debt" xlink:href="opk-20141231.xsd#Debt" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtFairValueOfEmbeddedDerivativesDetails" xlink:href="opk-20141231.xsd#DebtFairValueOfEmbeddedDerivativesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtInputsUsedInLatticeModelDetails" xlink:href="opk-20141231.xsd#DebtInputsUsedInLatticeModelDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtLinesOfCreditDetails" xlink:href="opk-20141231.xsd#DebtLinesOfCreditDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtMortgageNotesAndOtherDebtDetails" xlink:href="opk-20141231.xsd#DebtMortgageNotesAndOtherDebtDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtNotesDetails" xlink:href="opk-20141231.xsd#DebtNotesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtTables" xlink:href="opk-20141231.xsd#DebtTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DebtTextualDetails" xlink:href="opk-20141231.xsd#DebtTextualDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DerivativeContracts" xlink:href="opk-20141231.xsd#DerivativeContracts" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DerivativeContractsDetails" xlink:href="opk-20141231.xsd#DerivativeContractsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DerivativeContractsDetails1" xlink:href="opk-20141231.xsd#DerivativeContractsDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DerivativeContractsDetails2" xlink:href="opk-20141231.xsd#DerivativeContractsDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DerivativeContractsTables" xlink:href="opk-20141231.xsd#DerivativeContractsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/DocumentAndEntityInformation" xlink:href="opk-20141231.xsd#DocumentAndEntityInformation" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EmployeeBenefitPlans" xlink:href="opk-20141231.xsd#EmployeeBenefitPlans" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EmployeeBenefitPlansDetails" xlink:href="opk-20141231.xsd#EmployeeBenefitPlansDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EquityBasedCompensation" xlink:href="opk-20141231.xsd#EquityBasedCompensation" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationDetails" xlink:href="opk-20141231.xsd#EquityBasedCompensationDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationDetails1" xlink:href="opk-20141231.xsd#EquityBasedCompensationDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationDetailsTextual" xlink:href="opk-20141231.xsd#EquityBasedCompensationDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationTables" xlink:href="opk-20141231.xsd#EquityBasedCompensationTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurements" xlink:href="opk-20141231.xsd#FairValueMeasurements" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsAssetsAndLiabilitiesMeasuredAtFairValueDetails" xlink:href="opk-20141231.xsd#FairValueMeasurementsAssetsAndLiabilitiesMeasuredAtFairValueDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsLevel3ReconciliationDetails" xlink:href="opk-20141231.xsd#FairValueMeasurementsLevel3ReconciliationDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsNotesDetails" xlink:href="opk-20141231.xsd#FairValueMeasurementsNotesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsSummaryOfInvestmentsDetails" xlink:href="opk-20141231.xsd#FairValueMeasurementsSummaryOfInvestmentsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsTables" xlink:href="opk-20141231.xsd#FairValueMeasurementsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsTextualDetails" xlink:href="opk-20141231.xsd#FairValueMeasurementsTextualDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxes" xlink:href="opk-20141231.xsd#IncomeTaxes" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails" xlink:href="opk-20141231.xsd#IncomeTaxesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails1" xlink:href="opk-20141231.xsd#IncomeTaxesDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails2" xlink:href="opk-20141231.xsd#IncomeTaxesDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails3" xlink:href="opk-20141231.xsd#IncomeTaxesDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails4" xlink:href="opk-20141231.xsd#IncomeTaxesDetails4" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetails5" xlink:href="opk-20141231.xsd#IncomeTaxesDetails5" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesDetailsTextual" xlink:href="opk-20141231.xsd#IncomeTaxesDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/IncomeTaxesTables" xlink:href="opk-20141231.xsd#IncomeTaxesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/Leases" xlink:href="opk-20141231.xsd#Leases" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/LeasesDetails" xlink:href="opk-20141231.xsd#LeasesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/LeasesDetailsTextual" xlink:href="opk-20141231.xsd#LeasesDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/LeasesTables" xlink:href="opk-20141231.xsd#LeasesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/LossPerShare" xlink:href="opk-20141231.xsd#LossPerShare" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/LossPerShareDetails" xlink:href="opk-20141231.xsd#LossPerShareDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/RelatedPartyTransactions" xlink:href="opk-20141231.xsd#RelatedPartyTransactions" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/RelatedPartyTransactionsTextualDetails" xlink:href="opk-20141231.xsd#RelatedPartyTransactionsTextualDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/Segments" xlink:href="opk-20141231.xsd#Segments" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SegmentsDetails" xlink:href="opk-20141231.xsd#SegmentsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SegmentsDetailsTextual" xlink:href="opk-20141231.xsd#SegmentsDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SegmentsTables" xlink:href="opk-20141231.xsd#SegmentsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:href="opk-20141231.xsd#SelectedQuarterlyFinancialDataUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedDetails" xlink:href="opk-20141231.xsd#SelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:href="opk-20141231.xsd#SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ShareholdersEquity" xlink:href="opk-20141231.xsd#ShareholdersEquity" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ShareholdersEquityDetails" xlink:href="opk-20141231.xsd#ShareholdersEquityDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ShareholdersEquityDetailsTextual" xlink:href="opk-20141231.xsd#ShareholdersEquityDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/ShareholdersEquityTables" xlink:href="opk-20141231.xsd#ShareholdersEquityTables" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/StrategicAlliances" xlink:href="opk-20141231.xsd#StrategicAlliances" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/StrategicAlliancesStrategicAlliancesDetails" xlink:href="opk-20141231.xsd#StrategicAlliancesStrategicAlliancesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SubsequentEvents" xlink:href="opk-20141231.xsd#SubsequentEvents" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SubsequentEventsSubsequentEventsDetails" xlink:href="opk-20141231.xsd#SubsequentEventsSubsequentEventsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="opk-20141231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="opk-20141231.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="opk-20141231.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>
<definitionLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncome" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_12F21CB01DC59D39A235BE8014D74973" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0635BAAAAB74F7150248BE8014D712F7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_12F21CB01DC59D39A235BE8014D74973" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0635BAAAAB74F7150248BE8014D712F7" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_43E1D9EBF843B60C381BBE8014D78177" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_0635BAAAAB74F7150248BE8014D712F7" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_43E1D9EBF843B60C381BBE8014D78177" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_43E1D9EBF843B60C381BBE8014D78177" xlink:to="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_43E1D9EBF843B60C381BBE8014D78177" xlink:to="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_E439151DBABD4EE55CF2BE8014D7D929" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_E439151DBABD4EE55CF2BE8014D7D929" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_1C63191EBE5E15782D88BE8014D756A7" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFDF1164F7A67C21FE01BE8014D7A3A2" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_1C63191EBE5E15782D88BE8014D756A7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward" xlink:label="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_12F21CB01DC59D39A235BE8014D74973" xlink:to="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5B8EAF8D876FB5606B6EBE8014D7A77C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5B8EAF8D876FB5606B6EBE8014D7A77C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_7DD72A6E5B6551B7E0FABE8014D78D92" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_7DD72A6E5B6551B7E0FABE8014D78D92" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BE03CC2BCCBDDA33593BE8014D7A796" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BE03CC2BCCBDDA33593BE8014D7A796" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_D9AD07BD2E54C927ACA5BE8014D744A7" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_D2479CBB8D79DB02951CBE8014D743BD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_D9AD07BD2E54C927ACA5BE8014D744A7" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_7F598A69D69995A5EB8DCBC5878134A8" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_96FFB0314EF9411A1E12CBC587817720" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_7F598A69D69995A5EB8DCBC5878134A8" xlink:to="loc_us-gaap_StatementTable_96FFB0314EF9411A1E12CBC587817720" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5467122E5797D62A0E6BCBC58781CABE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_96FFB0314EF9411A1E12CBC587817720" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5467122E5797D62A0E6BCBC58781CABE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_C60738D0EE5317213C42CBC58781BE17_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5467122E5797D62A0E6BCBC58781CABE" xlink:to="loc_us-gaap_EquityComponentDomain_C60738D0EE5317213C42CBC58781BE17_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_C60738D0EE5317213C42CBC58781BE17" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5467122E5797D62A0E6BCBC58781CABE" xlink:to="loc_us-gaap_EquityComponentDomain_C60738D0EE5317213C42CBC58781BE17" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_FF88629737B4F1DB4BD0CBC58781556C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_C60738D0EE5317213C42CBC58781BE17" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_FF88629737B4F1DB4BD0CBC58781556C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_89A4F23C5CF749B0CA0FCBC587817D69" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7F598A69D69995A5EB8DCBC5878134A8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_89A4F23C5CF749B0CA0FCBC587817D69" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_C0FC20BE96D082582A2ECBC587819810" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7F598A69D69995A5EB8DCBC5878134A8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_C0FC20BE96D082582A2ECBC587819810" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_9A6F0396A802B3C52484CBC5878152C1" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7F598A69D69995A5EB8DCBC5878134A8" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_9A6F0396A802B3C52484CBC5878152C1" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicenses" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesScheduleOfConsolidatedAssetsAndNonRecourseLiabilitiesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_329B5FF4973F8BAE6A09B2B5E4A17882" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_C8421ADE15EB7DE00D2CB2B5E4A1341C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_329B5FF4973F8BAE6A09B2B5E4A17882" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_C8421ADE15EB7DE00D2CB2B5E4A1341C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_2EA4E1D4F772FCDB2527B2B5E4A1EC6E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_C8421ADE15EB7DE00D2CB2B5E4A1341C" xlink:to="loc_dei_LegalEntityAxis_2EA4E1D4F772FCDB2527B2B5E4A1EC6E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_7797809B9427FA804167B2B5E4A1D193_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_2EA4E1D4F772FCDB2527B2B5E4A1EC6E" xlink:to="loc_dei_EntityDomain_7797809B9427FA804167B2B5E4A1D193_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_7797809B9427FA804167B2B5E4A1D193" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_2EA4E1D4F772FCDB2527B2B5E4A1EC6E" xlink:to="loc_dei_EntityDomain_7797809B9427FA804167B2B5E4A1D193" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_F432079FE91F8F23B109B2B5E4A121F7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7797809B9427FA804167B2B5E4A1D193" xlink:to="loc_opk_SciVacMember_F432079FE91F8F23B109B2B5E4A121F7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_3238F2AE63480D71D82DB2B5E4A13AD4" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_C8421ADE15EB7DE00D2CB2B5E4A1341C" xlink:to="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_3238F2AE63480D71D82DB2B5E4A13AD4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_AB8779A05F986CFAC484B2B5E4A1550B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_3238F2AE63480D71D82DB2B5E4A13AD4" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_AB8779A05F986CFAC484B2B5E4A1550B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_AB8779A05F986CFAC484B2B5E4A1550B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_3238F2AE63480D71D82DB2B5E4A13AD4" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_AB8779A05F986CFAC484B2B5E4A1550B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_CF12FABDDD38002645AAB2B5E4A10F4F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_AB8779A05F986CFAC484B2B5E4A1550B" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_CF12FABDDD38002645AAB2B5E4A10F4F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_329B5FF4973F8BAE6A09B2B5E4A17882" xlink:to="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_B4B831691C5226F0C333B2B5E4A1156E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_B4B831691C5226F0C333B2B5E4A1156E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_3E753FC806430E744E36B2B5E4A1BCA6" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_3E753FC806430E744E36B2B5E4A1BCA6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_7DE86F88725B7654ACA9B2B5E4A1CC1B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:to="loc_us-gaap_InventoryNet_7DE86F88725B7654ACA9B2B5E4A1CC1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_725C359B7D1179C6A367B2B5E4A15181" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_725C359B7D1179C6A367B2B5E4A15181" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_D4107C704EE4FA2A26A1B2B5E4A18DB1" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_29E7506D867DBE7510CEB2B5E4A1C44D" xlink:to="loc_us-gaap_AssetsCurrent_D4107C704EE4FA2A26A1B2B5E4A18DB1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_E4E9374338168FB230E6B2B5E4A139F9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_E4E9374338168FB230E6B2B5E4A139F9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_09DBA8A1C82465CCBE96B2B5E4A19486" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_09DBA8A1C82465CCBE96B2B5E4A19486" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_B9E0AEE37DB4D3522708B2B5E4A13943" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_Goodwill_B9E0AEE37DB4D3522708B2B5E4A13943" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_54B3D64BEEDAE8063199B2B5E4A2EDD2" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_54B3D64BEEDAE8063199B2B5E4A2EDD2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_0E9318429E2A49C91D90B2B5E4A2AB4E" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_8B35E10AD1127D0361EFB2B5E4A13DA1" xlink:to="loc_us-gaap_Assets_0E9318429E2A49C91D90B2B5E4A2AB4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_584DBF0BD0BCF51A03DFB2B5E4A26416" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_329B5FF4973F8BAE6A09B2B5E4A17882" xlink:to="loc_us-gaap_LiabilitiesAbstract_584DBF0BD0BCF51A03DFB2B5E4A26416" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract_584DBF0BD0BCF51A03DFB2B5E4A26416" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_EE84153E8F3AC2CDB54BB2FDFEFD89E1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:to="loc_us-gaap_AccountsPayableCurrent_EE84153E8F3AC2CDB54BB2FDFEFD89E1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_00F61FC00D5B31608CD8B2B5E4A292D8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_00F61FC00D5B31608CD8B2B5E4A292D8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NotesPayableCurrent" xlink:label="loc_us-gaap_NotesPayableCurrent_F74C99A7ABBE7AE98783B2B5E4A285D0" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:to="loc_us-gaap_NotesPayableCurrent_F74C99A7ABBE7AE98783B2B5E4A285D0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_47CD8BDEC673B0CE27C6B2B5E4A28A63" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_A8EF5325EA879F33D487B2B5E4A21840" xlink:to="loc_us-gaap_LiabilitiesCurrent_47CD8BDEC673B0CE27C6B2B5E4A28A63" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_9C53F59953E55B41C24CB2B5E4A279B1" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract_584DBF0BD0BCF51A03DFB2B5E4A26416" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_9C53F59953E55B41C24CB2B5E4A279B1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_1271CE595C305D8E246BB2B5E4A22B23" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract_584DBF0BD0BCF51A03DFB2B5E4A26416" xlink:to="loc_us-gaap_Liabilities_1271CE595C305D8E246BB2B5E4A22B23" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_C2A5854729B1AB70BC729531AC55D6FB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_C2A5854729B1AB70BC729531AC55D6FB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_5389DFCA05FFC25973459531AC554A22" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_C2A5854729B1AB70BC729531AC55D6FB" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_5389DFCA05FFC25973459531AC554A22" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5389DFCA05FFC25973459531AC554A22" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5389DFCA05FFC25973459531AC554A22" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_F79C11358FC7ECCB32089567E8F073BA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372" xlink:to="loc_opk_OPKORenalMember_F79C11358FC7ECCB32089567E8F073BA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_E7D9D317221B1E592BE2956872873E5B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_493D03CAB866BA0B6BE29531AC55F372" xlink:to="loc_opk_OPKOBiologicsMember_E7D9D317221B1E592BE2956872873E5B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_F0DD9155D43A87813F289531AC56A0C6" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_C2A5854729B1AB70BC729531AC55D6FB" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_F0DD9155D43A87813F289531AC56A0C6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_46CE468232FE63D036F59531AC566978_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_F0DD9155D43A87813F289531AC56A0C6" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_46CE468232FE63D036F59531AC566978_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_46CE468232FE63D036F59531AC566978" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_F0DD9155D43A87813F289531AC56A0C6" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_46CE468232FE63D036F59531AC566978" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_3C0AF66B130EB543B1BF9531AC5620A3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_46CE468232FE63D036F59531AC566978" xlink:to="loc_us-gaap_InProcessResearchAndDevelopmentMember_3C0AF66B130EB543B1BF9531AC5620A3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_C7A7CF1BA6BACF77FC959531AC56634D" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_C2A5854729B1AB70BC729531AC55D6FB" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_C7A7CF1BA6BACF77FC959531AC56634D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_B363A70A1A5437648A249531AC56F63E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_C7A7CF1BA6BACF77FC959531AC56634D" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_B363A70A1A5437648A249531AC56F63E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_B363A70A1A5437648A249531AC56F63E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_C7A7CF1BA6BACF77FC959531AC56634D" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_B363A70A1A5437648A249531AC56F63E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PatentsMember" xlink:label="loc_us-gaap_PatentsMember_E542EA0D7E6BC096A9E59531AC562DDF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_B363A70A1A5437648A249531AC56F63E" xlink:to="loc_us-gaap_PatentsMember_E542EA0D7E6BC096A9E59531AC562DDF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_54E44B83B6EAC7BC25469531AC5698DA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_54E44B83B6EAC7BC25469531AC5698DA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract_36FFE4A52CB5D47130F99531AC5693C2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract_36FFE4A52CB5D47130F99531AC5693C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_347A6A5FF54CD13BCB099531AC5696BC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract_36FFE4A52CB5D47130F99531AC5693C2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_347A6A5FF54CD13BCB099531AC5696BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_9C03272D980544FBF2139531AC56355C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract_36FFE4A52CB5D47130F99531AC5693C2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_9C03272D980544FBF2139531AC56355C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_50597482B71D1891EBDE9531AC565E36" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwillAbstract_36FFE4A52CB5D47130F99531AC5693C2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_50597482B71D1891EBDE9531AC565E36" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_5004369CE6B0B331D00D9531AC572689" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_Goodwill_5004369CE6B0B331D00D9531AC572689" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_744ECEDF4E1412B1B1039531AC575535" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_744ECEDF4E1412B1B1039531AC575535" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_16B2F33B60F00EE266799531AC57A892" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_16B2F33B60F00EE266799531AC57A892" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableAndAccruedExpenses" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableAndAccruedExpenses_E328D29832BF37677AC79531AC577CD6" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableAndAccruedExpenses_E328D29832BF37677AC79531AC577CD6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_65405FEC7CC1DD951C279531AC57EFC6" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_65405FEC7CC1DD951C279531AC57EFC6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_908299C67DB84E496D0B9531AC579334" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_908299C67DB84E496D0B9531AC579334" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A458BF5F07205F5300C19531AC579096" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3D88EC2F1210D40C281C9531AC56BE3F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_A458BF5F07205F5300C19531AC579096" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfInvestmentsDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfProFormaResultsDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4263939E7F8C4BAD70DEC8ABB5D2FF5B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4263939E7F8C4BAD70DEC8ABB5D2FF5B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_5DF0FDB1690952E4BF45C8ABB5D24FE1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4263939E7F8C4BAD70DEC8ABB5D2FF5B" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_5DF0FDB1690952E4BF45C8ABB5D24FE1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5DF0FDB1690952E4BF45C8ABB5D24FE1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5DF0FDB1690952E4BF45C8ABB5D24FE1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalandOPKOBiologicsMember" xlink:label="loc_opk_OPKORenalandOPKOBiologicsMember_DD5747EE9157A77083D7C8ABB5D2F898" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E" xlink:to="loc_opk_OPKORenalandOPKOBiologicsMember_DD5747EE9157A77083D7C8ABB5D2F898" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_4436028E54EDD66100FEC8ABB5D2E144" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7F7550D1A655B8F384DEC8ABB5D22A9E" xlink:to="loc_opk_SciVacMember_4436028E54EDD66100FEC8ABB5D2E144" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_E6CC43B31C1B8F0AE802C8ABB5D29600" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_E6CC43B31C1B8F0AE802C8ABB5D29600" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_097E911EB4FF8BFE3673C8ABB5D32E6A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:to="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_097E911EB4FF8BFE3673C8ABB5D32E6A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentTableTextBlock" xlink:label="loc_invest_InvestmentTableTextBlock_4F08CD915D72408B63F5C8ABB5D35DA1" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:to="loc_invest_InvestmentTableTextBlock_4F08CD915D72408B63F5C8ABB5D35DA1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTextBlock" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_580AE098DB7C8D6E820BC8ABB5D2F63F" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7F77C9C142D91CFBDA12C8ABB5D289A6" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_580AE098DB7C8D6E820BC8ABB5D2F63F" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTextualDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_4BF54B00A5E934C1E5B1BDB36723D8A0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_4BF54B00A5E934C1E5B1BDB36723D8A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_4BF54B00A5E934C1E5B1BDB36723D8A0" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_4BF54B00A5E934C1E5B1BDB36723D8A0" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherExpenseMember" xlink:label="loc_us-gaap_OtherExpenseMember_827A4F419264D3D9EE76BDB3672405E4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7" xlink:to="loc_us-gaap_OtherExpenseMember_827A4F419264D3D9EE76BDB3672405E4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherIncomeMember" xlink:label="loc_us-gaap_OtherIncomeMember_D3A645E88CD93D158B69BDB36724A2F1" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_A5D9CFD1F77A4DB16192BDB367248EC7" xlink:to="loc_us-gaap_OtherIncomeMember_D3A645E88CD93D158B69BDB36724A2F1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_87373EE524CA0F56FEF2BDB36724A817" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_invest_InvestmentAxis_87373EE524CA0F56FEF2BDB36724A817" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_invest_InvestmentAxis_87373EE524CA0F56FEF2BDB36724A817" xlink:to="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_invest_InvestmentAxis_87373EE524CA0F56FEF2BDB36724A817" xlink:to="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ChromaDexMember" xlink:label="loc_opk_ChromaDexMember_7BD245F64070B95FFB1ABDB3672487A6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_ChromaDexMember_7BD245F64070B95FFB1ABDB3672487A6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RxiMember" xlink:label="loc_opk_RxiMember_B6544F34FAA6B0A98B4BBDB36724240F" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_RxiMember_B6544F34FAA6B0A98B4BBDB36724240F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NIMSMember" xlink:label="loc_opk_NIMSMember_6992C52269B2775D2E90BDB36724C9B4" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_NIMSMember_6992C52269B2775D2E90BDB36724C9B4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_0F563EAF50CEA0B2612FBDB367240FF7" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_CocrystalMember_0F563EAF50CEA0B2612FBDB367240FF7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_592A24E945EAA0AD1C36BDB36724F11A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_PharmsynthezMember_592A24E945EAA0AD1C36BDB36724F11A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SevionMember" xlink:label="loc_opk_SevionMember_699B2BC39DD6570DDE8BBDB36725DE2C" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_SevionMember_699B2BC39DD6570DDE8BBDB36725DE2C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NeovascMember" xlink:label="loc_opk_NeovascMember_F9089F995F2BB0DDFDA6BDB367251BF9" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_NeovascMember_F9089F995F2BB0DDFDA6BDB367251BF9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ARNOMember" xlink:label="loc_opk_ARNOMember_E9D9D69D8D2ED72CAE81BDB36725FD9B" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_B38F93D58CD50472CEDEBDB36724F4EA" xlink:to="loc_opk_ARNOMember_E9D9D69D8D2ED72CAE81BDB36725FD9B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_8A2E9417865390CBA350BDB3672518CC" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_8A2E9417865390CBA350BDB3672518CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8A2E9417865390CBA350BDB3672518CC" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8A2E9417865390CBA350BDB3672518CC" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBrazilMember" xlink:label="loc_opk_OPKOBrazilMember_630F4CBE7BB21DEB2622BDB36725E0C2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:to="loc_opk_OPKOBrazilMember_630F4CBE7BB21DEB2622BDB36725E0C2" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_InspiroMedicalLtd.Member" xlink:label="loc_opk_InspiroMedicalLtd.Member_443B7495008EA0CD823FBDB36725A028" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:to="loc_opk_InspiroMedicalLtd.Member_443B7495008EA0CD823FBDB36725A028" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PROLORMember" xlink:label="loc_opk_PROLORMember_E33CF33FAB822D60D443BDB3672638FE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:to="loc_opk_PROLORMember_E33CF33FAB822D60D443BDB3672638FE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_ECF737F7D0AA8A2D56E3BDB36726E534" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4804DBC84D5CDCE93F27BDB367253A1C" xlink:to="loc_opk_OPKORenalMember_ECF737F7D0AA8A2D56E3BDB36726E534" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7EDD347EAA2EDEB1E440BDB367263736" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7EDD347EAA2EDEB1E440BDB367263736" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7EDD347EAA2EDEB1E440BDB367263736" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7EDD347EAA2EDEB1E440BDB367263736" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_D40C2BB9F00B3A90720FBDB367268E42" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_CocrystalMember_D40C2BB9F00B3A90720FBDB367268E42" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SevionMember" xlink:label="loc_opk_SevionMember_CE28BAF8D423CCB6F6E4BDB3672611A2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_SevionMember_CE28BAF8D423CCB6F6E4BDB3672611A2" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ARNOMember" xlink:label="loc_opk_ARNOMember_1DDDAE0C06AEDF24C7D7BDB36726E5CD" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_ARNOMember_1DDDAE0C06AEDF24C7D7BDB36726E5CD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NeovascMember" xlink:label="loc_opk_NeovascMember_99C95F3B635C98CF3BFDBDB367264406" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_NeovascMember_99C95F3B635C98CF3BFDBDB367264406" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_4A495F932F5AFE84E261BDB367263D63" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_PharmsynthezMember_4A495F932F5AFE84E261BDB367263D63" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ZebraMember" xlink:label="loc_opk_ZebraMember_6550F28505EAB8678FDABDB36726724A" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_BB85FE38E9F3D88C5E5DBDB3672650F9" xlink:to="loc_opk_ZebraMember_6550F28505EAB8678FDABDB36726724A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_EA9A61FA64900BE863C1BDB367279EEF" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_us-gaap_StatementClassOfStockAxis_EA9A61FA64900BE863C1BDB367279EEF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_EA9A61FA64900BE863C1BDB367279EEF" xlink:to="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_EA9A61FA64900BE863C1BDB367279EEF" xlink:to="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_0036F54AD829BB1EF9C6BDB3672759A1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_0036F54AD829BB1EF9C6BDB3672759A1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_F3F3AED8BF6E759254A6BDB36727EFB2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_187D326C1CFB105A324DBDB3672768A2" xlink:to="loc_us-gaap_RestrictedStockMember_F3F3AED8BF6E759254A6BDB36727EFB2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_BD1A143B814E11FB8586BDB3672727A8" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_dei_LegalEntityAxis_BD1A143B814E11FB8586BDB3672727A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_6590E7E77E7E91811001BDB367279F7D_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_BD1A143B814E11FB8586BDB3672727A8" xlink:to="loc_dei_EntityDomain_6590E7E77E7E91811001BDB367279F7D_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_6590E7E77E7E91811001BDB367279F7D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_BD1A143B814E11FB8586BDB3672727A8" xlink:to="loc_dei_EntityDomain_6590E7E77E7E91811001BDB367279F7D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_D9DACB33A29890F82F57BDB36727351C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6590E7E77E7E91811001BDB367279F7D" xlink:to="loc_opk_SciVacMember_D9DACB33A29890F82F57BDB36727351C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_1FC57D29CB1DED5CA93FBDB36727C8FC" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_70CB3A078DE32EB3F7E6BDB36723819B" xlink:to="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_1FC57D29CB1DED5CA93FBDB36727C8FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_1FC57D29CB1DED5CA93FBDB36727C8FC" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_1FC57D29CB1DED5CA93FBDB36727C8FC" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember_F4881D23515D6780862EBDB367271333" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F" xlink:to="loc_us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember_F4881D23515D6780862EBDB367271333" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_2C8CF467923FE9503EE9BDB36727DB0B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_35CBD5C429B62C92E730BDB36727738F" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_2C8CF467923FE9503EE9BDB36727DB0B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D407E9059AA028BEF764BDB36728D0D7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D407E9059AA028BEF764BDB36728D0D7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_4A001257574A1242BAF7BDB36728599B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_4A001257574A1242BAF7BDB36728599B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_99ACA8B2FDFCE534185FBDB36728AFB0" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_99ACA8B2FDFCE534185FBDB36728AFB0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessAcquisitionEquityInterestIssuedorIssuableNumberOfTradingDaysToCalculateVolumeWeighteAverageSharePrice" xlink:label="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableNumberOfTradingDaysToCalculateVolumeWeighteAverageSharePrice_AE2DDB2D902BDCA781B7BDB367281B83" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableNumberOfTradingDaysToCalculateVolumeWeighteAverageSharePrice_AE2DDB2D902BDCA781B7BDB367281B83" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_C957EC51C9A9B6B916B7BDB36728EDB3" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_SharePrice_C957EC51C9A9B6B916B7BDB36728EDB3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentInProcess" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_C008AB210CDF3221CC29BDB36728EDF0" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_ResearchAndDevelopmentInProcess_C008AB210CDF3221CC29BDB36728EDF0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessAcquisitionEquityInterestIssuedorIssuableConversionRatio" xlink:label="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableConversionRatio_A8B86F3E87FAD76C33CEBDB36728E2DB" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableConversionRatio_A8B86F3E87FAD76C33CEBDB36728E2DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_679A3A764A415F0B1FC7BDB3672899D7" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_679A3A764A415F0B1FC7BDB3672899D7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_C371B0076ECE024EA677BDB367288657" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_C371B0076ECE024EA677BDB367288657" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_FCFEBEC9EE34362E91DEBDB36728B8F4" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_FCFEBEC9EE34362E91DEBDB36728B8F4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PercentageofShareholdingbyChairmanofAcquireeCompany" xlink:label="loc_opk_PercentageofShareholdingbyChairmanofAcquireeCompany_4E8D6D9EF095B2C23158BDB367283ABC" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_PercentageofShareholdingbyChairmanofAcquireeCompany_4E8D6D9EF095B2C23158BDB367283ABC" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PercentageofShareholdingbyDirectorsofAcquireeCompany" xlink:label="loc_opk_PercentageofShareholdingbyDirectorsofAcquireeCompany_79B3303DFCA9F4DF5BD8BDB3672848C5" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_PercentageofShareholdingbyDirectorsofAcquireeCompany_79B3303DFCA9F4DF5BD8BDB3672848C5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessAcquisitionEquityInterestIssuedOrIssuableVolumeWeightedAveragePricePerShare" xlink:label="loc_opk_BusinessAcquisitionEquityInterestIssuedOrIssuableVolumeWeightedAveragePricePerShare_D5C628A8993389FE9633BDB36729F2BD" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_BusinessAcquisitionEquityInterestIssuedOrIssuableVolumeWeightedAveragePricePerShare_D5C628A8993389FE9633BDB36729F2BD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_989462AB3DED28D9719FBDB3672992F9" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_989462AB3DED28D9719FBDB3672992F9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_815A37E0F256158030BBBDB3672952F8" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_815A37E0F256158030BBBDB3672952F8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_6430096276F2D511D491BDB3672997BD" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_6430096276F2D511D491BDB3672997BD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentNumberOfSharesPurchased" xlink:label="loc_opk_EquityMethodInvestmentNumberOfSharesPurchased_BE6BF6390BCF1B39BD7BBDB367290211" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_EquityMethodInvestmentNumberOfSharesPurchased_BE6BF6390BCF1B39BD7BBDB367290211" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentAmountOfSharesPurchased" xlink:label="loc_opk_EquityMethodInvestmentAmountOfSharesPurchased_756E6808E92C49077578BDB36729892A" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_EquityMethodInvestmentAmountOfSharesPurchased_756E6808E92C49077578BDB36729892A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentNoteReceivableShareOption" xlink:label="loc_opk_EquityMethodInvestmentNoteReceivableShareOption_D63001039C919063A5F2BDB367295A4C" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_EquityMethodInvestmentNoteReceivableShareOption_D63001039C919063A5F2BDB367295A4C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentNoteReceivableCashOption" xlink:label="loc_opk_EquityMethodInvestmentNoteReceivableCashOption_98C917A6F3D44316F2AEBDB36729CE82" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_EquityMethodInvestmentNoteReceivableCashOption_98C917A6F3D44316F2AEBDB36729CE82" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SharesReceivedInSatisfactionofNotesReceivable" xlink:label="loc_opk_SharesReceivedInSatisfactionofNotesReceivable_3FC632C1CEA0E858727EBDB36729E687" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_SharesReceivedInSatisfactionofNotesReceivable_3FC632C1CEA0E858727EBDB36729E687" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_F3D249B77E6B5BCFFAC7BDB367297BA3" xlink:type="locator"/>
<definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_DeferredRevenue_F3D249B77E6B5BCFFAC7BDB367297BA3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod" xlink:label="loc_opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod_4A0DE5EA9C9D449F4491BDB367298B18" xlink:type="locator"/>
<definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod_4A0DE5EA9C9D449F4491BDB367298B18" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DeferredRevenueReceivedFromCollaborationAgreement" xlink:label="loc_opk_DeferredRevenueReceivedFromCollaborationAgreement_963F8B419B2E94BF6228BDB3672954C6" xlink:type="locator"/>
<definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_DeferredRevenueReceivedFromCollaborationAgreement_963F8B419B2E94BF6228BDB3672954C6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LicenseAndServicesRevenue" xlink:label="loc_us-gaap_LicenseAndServicesRevenue_D9F2556E3CC52A33AE24BDB36729A316" xlink:type="locator"/>
<definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_LicenseAndServicesRevenue_D9F2556E3CC52A33AE24BDB36729A316" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueReceivedFromCollaborationAgreementOffsettoResearchandDevelopment" xlink:label="loc_opk_RevenueReceivedFromCollaborationAgreementOffsettoResearchandDevelopment_FAEBC6F59F522D7AE551BDB367290DD2" xlink:type="locator"/>
<definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_RevenueReceivedFromCollaborationAgreementOffsettoResearchandDevelopment_FAEBC6F59F522D7AE551BDB367290DD2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InvestmentOwnedBalanceShares" xlink:label="loc_us-gaap_InvestmentOwnedBalanceShares_5B884B47688D57A9DD39BDB3672ABAC7" xlink:type="locator"/>
<definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_InvestmentOwnedBalanceShares_5B884B47688D57A9DD39BDB3672ABAC7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="loc_us-gaap_VariableInterestEntityOwnershipPercentage_4D8C3608D82C4A21CFEDBDB3672AC3CE" xlink:type="locator"/>
<definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_VariableInterestEntityOwnershipPercentage_4D8C3608D82C4A21CFEDBDB3672AC3CE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DueFromAffiliates" xlink:label="loc_us-gaap_DueFromAffiliates_3089104DBD52320A26D9BDB3672ADDBF" xlink:type="locator"/>
<definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_DueFromAffiliates_3089104DBD52320A26D9BDB3672ADDBF" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_B49794FCFCBE8EA4BEE0BDB3672AE6C5" xlink:type="locator"/>
<definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_B49794FCFCBE8EA4BEE0BDB3672AE6C5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_7959BEDE34AAEDBFDE0EBDB3672AA8FA" xlink:type="locator"/>
<definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_7959BEDE34AAEDBFDE0EBDB3672AA8FA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_B73C1E64B553233F723BBDB3672A3CF6" xlink:type="locator"/>
<definitionArc order="32" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_B73C1E64B553233F723BBDB3672A3CF6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SharesReceivedAsGift" xlink:label="loc_opk_SharesReceivedAsGift_A98D44CCAAC5435207E9BDB3672BB753" xlink:type="locator"/>
<definitionArc order="33" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_SharesReceivedAsGift_A98D44CCAAC5435207E9BDB3672BB753" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_7FDA99C8BBAFFF679E1BBDB3672B92CA" xlink:type="locator"/>
<definitionArc order="34" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_7FDA99C8BBAFFF679E1BBDB3672B92CA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_B570E7786374B772F901BDB3672B7743" xlink:type="locator"/>
<definitionArc order="35" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_B570E7786374B772F901BDB3672B7743" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_D43CCCE9B0138CCA161BBDB3672BAB53" xlink:type="locator"/>
<definitionArc order="36" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_D43CCCE9B0138CCA161BBDB3672BAB53" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_DA664243FD59048DD813BDB3672B07BA" xlink:type="locator"/>
<definitionArc order="37" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_DA664243FD59048DD813BDB3672B07BA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentQuotedMarketValue" xlink:label="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_B0A11BC19929BC3CED8BBDB3672B3B83" xlink:type="locator"/>
<definitionArc order="38" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_B0A11BC19929BC3CED8BBDB3672B3B83" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_4290072B4145B32FCACDBDB3672BE1A1" xlink:type="locator"/>
<definitionArc order="39" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_4290072B4145B32FCACDBDB3672BE1A1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherThanTemporaryImpairmentLossesInvestmentsPortionRecognizedInEarningsNetAvailableforsaleSecurities" xlink:label="loc_us-gaap_OtherThanTemporaryImpairmentLossesInvestmentsPortionRecognizedInEarningsNetAvailableforsaleSecurities_BAE434121CB931A4245EBDB3672BAD14" xlink:type="locator"/>
<definitionArc order="40" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_OtherThanTemporaryImpairmentLossesInvestmentsPortionRecognizedInEarningsNetAvailableforsaleSecurities_BAE434121CB931A4245EBDB3672BAD14" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_22B4BB9FD4CE93631257BDB3672B94E2" xlink:type="locator"/>
<definitionArc order="41" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_22B4BB9FD4CE93631257BDB3672B94E2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_BF295A7AE1E6007E9944BDB3672B0DD3" xlink:type="locator"/>
<definitionArc order="42" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_02ED03748CAF7E9E719FBDB36727E2B9" xlink:to="loc_us-gaap_GainLossOnSaleOfInvestments_BF295A7AE1E6007E9944BDB3672B0DD3" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/BusinessAndOrganization" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/CommitmentsAndContingencies" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/CommitmentsAndContingenciesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_BD6A7FD6B33247A9BA83985C95FE7260" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_CCF75092487F07B239EF985C95FE4F76" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_BD6A7FD6B33247A9BA83985C95FE7260" xlink:to="loc_us-gaap_LossContingenciesTable_CCF75092487F07B239EF985C95FE4F76" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationStatusAxis" xlink:label="loc_us-gaap_LitigationStatusAxis_AABC4366899F291086ED985C95FEA771" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_CCF75092487F07B239EF985C95FE4F76" xlink:to="loc_us-gaap_LitigationStatusAxis_AABC4366899F291086ED985C95FEA771" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_us-gaap_LitigationStatusDomain_7F939E237560D4F20113985C95FE8F65_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_AABC4366899F291086ED985C95FEA771" xlink:to="loc_us-gaap_LitigationStatusDomain_7F939E237560D4F20113985C95FE8F65_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_us-gaap_LitigationStatusDomain_7F939E237560D4F20113985C95FE8F65" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_AABC4366899F291086ED985C95FEA771" xlink:to="loc_us-gaap_LitigationStatusDomain_7F939E237560D4F20113985C95FE8F65" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PendingLitigationMember" xlink:label="loc_us-gaap_PendingLitigationMember_3EEF3F2B61B2B484EE26985C95FE0C62" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_7F939E237560D4F20113985C95FE8F65" xlink:to="loc_us-gaap_PendingLitigationMember_3EEF3F2B61B2B484EE26985C95FE0C62" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationCaseAxis" xlink:label="loc_us-gaap_LitigationCaseAxis_12F37F9CEDF0331FF116985C95FE6E85" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_CCF75092487F07B239EF985C95FE4F76" xlink:to="loc_us-gaap_LitigationCaseAxis_12F37F9CEDF0331FF116985C95FE6E85" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_293B9C3E63A433F98D9A985C95FED312_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationCaseAxis_12F37F9CEDF0331FF116985C95FE6E85" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_293B9C3E63A433F98D9A985C95FED312_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_293B9C3E63A433F98D9A985C95FED312" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationCaseAxis_12F37F9CEDF0331FF116985C95FE6E85" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_293B9C3E63A433F98D9A985C95FED312" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PROLORBiotechInc.ShareholdersLitigationMember" xlink:label="loc_opk_PROLORBiotechInc.ShareholdersLitigationMember_D5A95A3A2EF7E9FD4935985C95FE6394" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_293B9C3E63A433F98D9A985C95FED312" xlink:to="loc_opk_PROLORBiotechInc.ShareholdersLitigationMember_D5A95A3A2EF7E9FD4935985C95FE6394" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LossContingencyNewClaimsFiledNumber" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_DC65C5253EC04869FC7E985C95FE116D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_BD6A7FD6B33247A9BA83985C95FE7260" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_DC65C5253EC04869FC7E985C95FE116D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit" xlink:label="loc_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_EFE7B3C7C7706407378B985C95FE88CF" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_BD6A7FD6B33247A9BA83985C95FE7260" xlink:to="loc_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_EFE7B3C7C7706407378B985C95FE88CF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PurchaseObligation" xlink:label="loc_us-gaap_PurchaseObligation_8DC7714A10CFE90EEE339881590E9605" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_BD6A7FD6B33247A9BA83985C95FE7260" xlink:to="loc_us-gaap_PurchaseObligation_8DC7714A10CFE90EEE339881590E9605" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_815DC0FE79901BD8897B985C95FE9B76" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_D76F2E2F1ED206D8AAAD985C95FE4DA9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_815DC0FE79901BD8897B985C95FE9B76" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_D76F2E2F1ED206D8AAAD985C95FE4DA9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_35757FA3ADBCD954802498751AD9D60B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_D76F2E2F1ED206D8AAAD985C95FE4DA9" xlink:to="loc_us-gaap_CounterpartyNameAxis_35757FA3ADBCD954802498751AD9D60B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_72AB6918F427C82FAC5998751ADA8587_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_35757FA3ADBCD954802498751AD9D60B" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_72AB6918F427C82FAC5998751ADA8587_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_72AB6918F427C82FAC5998751ADA8587" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_35757FA3ADBCD954802498751AD9D60B" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_72AB6918F427C82FAC5998751ADA8587" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_MerckMember" xlink:label="loc_opk_MerckMember_1B425665ED0AC34E51D898751B5DC6C0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_72AB6918F427C82FAC5998751ADA8587" xlink:to="loc_opk_MerckMember_1B425665ED0AC34E51D898751B5DC6C0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_A8C2320230042B5B231A985C95FE7BAA" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_D76F2E2F1ED206D8AAAD985C95FE4DA9" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_A8C2320230042B5B231A985C95FE7BAA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_A8C2320230042B5B231A985C95FE7BAA" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_A8C2320230042B5B231A985C95FE7BAA" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_44EE31FA173BAD255581985C95FEBB24" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_44EE31FA173BAD255581985C95FEBB24" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_824C44E3D545FEA2E421985C95FECFE8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_C07185A5760E1BA4B846985C95FEF730" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_824C44E3D545FEA2E421985C95FECFE8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_A31D71B695A5296AEF73985C95FEDBB7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_815DC0FE79901BD8897B985C95FE9B76" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_A31D71B695A5296AEF73985C95FEDBB7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeAgreementAdditionalMilestonePayment" xlink:label="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_DBD78EDCD95F6F65D90598751A5A346B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_815DC0FE79901BD8897B985C95FE9B76" xlink:to="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_DBD78EDCD95F6F65D90598751A5A346B" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptions" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CondensedFinancialStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfCondensedFinancialStatementsTable" xlink:label="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_AB9AC3E8BF097BB259E5C6F6BF3A0923" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_AB9AC3E8BF097BB259E5C6F6BF3A0923" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9712F4EC5F10E26E78D5C6F6BF3AEB2A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_AB9AC3E8BF097BB259E5C6F6BF3A0923" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9712F4EC5F10E26E78D5C6F6BF3AEB2A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9712F4EC5F10E26E78D5C6F6BF3AEB2A" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_9712F4EC5F10E26E78D5C6F6BF3AEB2A" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_301FD33CCAE387A03074C6F6BF3AC615" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_301FD33CCAE387A03074C6F6BF3AC615" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_70BAB904E7371BC1DCB0C6F6BF3A2F4B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_us-gaap_CustomerRelationshipsMember_70BAB904E7371BC1DCB0C6F6BF3A2F4B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ProductRegistrationsMember" xlink:label="loc_opk_ProductRegistrationsMember_E8A2E39AD630E92E7285C6F6BF3A1FA9" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_opk_ProductRegistrationsMember_E8A2E39AD630E92E7285C6F6BF3A1FA9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TradeNamesMember" xlink:label="loc_us-gaap_TradeNamesMember_320A939A1FA8CCCD9E09C6F6BF3AA81A" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_us-gaap_TradeNamesMember_320A939A1FA8CCCD9E09C6F6BF3AA81A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncompeteAgreementsMember" xlink:label="loc_us-gaap_NoncompeteAgreementsMember_DCF48BF439E26AF526DDC6F6BF3AAE49" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_us-gaap_NoncompeteAgreementsMember_DCF48BF439E26AF526DDC6F6BF3AAE49" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_B59A430D67F74BAC7B3EC6F6BF3A6B49" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_477A8AE592C2F51B5A1CC6F6BF3AEA94" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_B59A430D67F74BAC7B3EC6F6BF3A6B49" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_BADEAA6EC1FAFDC2CD0BC6F6BF3AF1F8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_AB9AC3E8BF097BB259E5C6F6BF3A0923" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_BADEAA6EC1FAFDC2CD0BC6F6BF3AF1F8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BADEAA6EC1FAFDC2CD0BC6F6BF3AF1F8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BADEAA6EC1FAFDC2CD0BC6F6BF3AF1F8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_5BB469AD24D27EE512B4C6F6BF3ACA45" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:to="loc_opk_OPKORenalMember_5BB469AD24D27EE512B4C6F6BF3ACA45" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_4154DFBD41CFF9F5822DC6F6BF3ACB6C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:to="loc_opk_OPKOHealthEuropeMember_4154DFBD41CFF9F5822DC6F6BF3ACB6C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_BBD789182E72CB98095AC6F6BF3BA427" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:to="loc_opk_OpkoDiagnosticsMember_BBD789182E72CB98095AC6F6BF3BA427" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_F5D06420A5BD6F5E7160C6F6BF3B509D" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4FA39AD324820ECC1FB7C6F6BF3A844D" xlink:to="loc_opk_CURNAMember_F5D06420A5BD6F5E7160C6F6BF3B509D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableNetAbstract" xlink:label="loc_us-gaap_AccountsReceivableNetAbstract_2ED24420B024A3250B9DC6F6BF3B7EE7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_AccountsReceivableNetAbstract_2ED24420B024A3250B9DC6F6BF3B7EE7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_03EF214E588087161C0FC6F6BF3B4BF2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsReceivableNetAbstract_2ED24420B024A3250B9DC6F6BF3B7EE7" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_03EF214E588087161C0FC6F6BF3B4BF2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_CCC0DB967D73ADF5C840C6F6BF3BB601" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsReceivableNetAbstract_2ED24420B024A3250B9DC6F6BF3B7EE7" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_CCC0DB967D73ADF5C840C6F6BF3BB601" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_403873BF9634F0270A15C6F6BF3B0B97" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsReceivableNetAbstract_2ED24420B024A3250B9DC6F6BF3B7EE7" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_403873BF9634F0270A15C6F6BF3B0B97" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_AD2A1FE7CF097550187FC6F6BF3BD66C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:to="loc_us-gaap_InventoryFinishedGoods_AD2A1FE7CF097550187FC6F6BF3BD66C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_9B2DF1D58AD78BE0344CC6F6BF3B8102" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:to="loc_us-gaap_InventoryWorkInProcess_9B2DF1D58AD78BE0344CC6F6BF3B8102" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_AE2CE3C2F1CCD906FDA9C6F6BF3BE59A" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:to="loc_us-gaap_InventoryRawMaterials_AE2CE3C2F1CCD906FDA9C6F6BF3BE59A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_us-gaap_InventoryValuationReserves_46E9C8FF4796D007E726C6F6BF3B0E5E" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:to="loc_us-gaap_InventoryValuationReserves_46E9C8FF4796D007E726C6F6BF3B0E5E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_F78965E3EB0D8BE830D4C6F6BF3BC82A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_DA482FD7C5D4815F2420C6F6BF3BD515" xlink:to="loc_us-gaap_InventoryNet_F78965E3EB0D8BE830D4C6F6BF3BC82A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Supplies" xlink:label="loc_us-gaap_Supplies_8DD74B45F91B255CFB4BC6F6BF3B5FF3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_Supplies_8DD74B45F91B255CFB4BC6F6BF3B5FF3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaap_PrepaidInsurance_D8FAB7FA920DF7A5845FC6F6BF3B9958" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_PrepaidInsurance_D8FAB7FA920DF7A5845FC6F6BF3B9958" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NotesAndLoansReceivableNetCurrent" xlink:label="loc_us-gaap_NotesAndLoansReceivableNetCurrent_33153E31BFB749B8DC62C6F6BF3B49ED" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_NotesAndLoansReceivableNetCurrent_33153E31BFB749B8DC62C6F6BF3B49ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_C5A33EED8FEDB178821EC6F6BF3B89F3" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_C5A33EED8FEDB178821EC6F6BF3B89F3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TaxesRecoverableCurrent" xlink:label="loc_opk_TaxesRecoverableCurrent_5F892C9D22F66F2D1693C6F6BF3BC54A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_opk_TaxesRecoverableCurrent_5F892C9D22F66F2D1693C6F6BF3BC54A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_275A9C755B83048BE18EC6F6BF3CBEBA" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_OtherAssetsCurrent_275A9C755B83048BE18EC6F6BF3CBEBA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_729FBABF70FAFE799618C6F6BF3CCF54" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_20A3D15E2CB78C340E66C6F6BF3B12DF" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_729FBABF70FAFE799618C6F6BF3CCF54" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MachineryAndEquipmentGross" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_0CD3709E9759B3037062C6F6BF3C3731" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_0CD3709E9759B3037062C6F6BF3C3731" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BuildingsAndImprovementsGross" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_43E659AA4C30147466E5C6F6BF3C9785" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_43E659AA4C30147466E5C6F6BF3C9785" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Land" xlink:label="loc_us-gaap_Land_F5FAFEF0596BD59C4114C6F6BF3C30FA" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_Land_F5FAFEF0596BD59C4114C6F6BF3C30FA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FurnitureAndFixturesGross" xlink:label="loc_us-gaap_FurnitureAndFixturesGross_5D76EE4677AD6D54862BC6F6BF3C42C1" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_FurnitureAndFixturesGross_5D76EE4677AD6D54862BC6F6BF3C42C1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CapitalizedComputerSoftwareGross" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareGross_A8BB191134F18CF6CF84C6F6BF3CBA76" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareGross_A8BB191134F18CF6CF84C6F6BF3CBA76" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LeaseholdImprovementsGross" xlink:label="loc_us-gaap_LeaseholdImprovementsGross_E181D3D9B511398B1DD3C6F6BF3CE9A9" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_LeaseholdImprovementsGross_E181D3D9B511398B1DD3C6F6BF3CE9A9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConstructionInProgressGross" xlink:label="loc_us-gaap_ConstructionInProgressGross_72690D14CFE1D15EEED0C6F6BF3C2500" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_ConstructionInProgressGross_72690D14CFE1D15EEED0C6F6BF3C2500" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_E2FDFCF74291F5A75011C6F6BF3C272E" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_E2FDFCF74291F5A75011C6F6BF3C272E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_5A65C0B3D1B95595F4EBC6F6BF3C8F43" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D3A96C0C99621362C72CC6F6BF3CC85D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_5A65C0B3D1B95595F4EBC6F6BF3C8F43" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_658E30558CB4A9378FADC6F6BF3C92FC" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_658E30558CB4A9378FADC6F6BF3C92FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_769DAEB283041B40CC96C6F6BF3CA55F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_658E30558CB4A9378FADC6F6BF3C92FC" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_769DAEB283041B40CC96C6F6BF3CA55F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ECC17027276970E44203C6F6BF3CF817" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_658E30558CB4A9378FADC6F6BF3C92FC" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ECC17027276970E44203C6F6BF3CF817" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6EE084C23C27B79C13C5C6F6BF3C4458" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_658E30558CB4A9378FADC6F6BF3C92FC" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6EE084C23C27B79C13C5C6F6BF3C4458" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_BABC1193C474FAB1B044C6F6BF3CDAB8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_BABC1193C474FAB1B044C6F6BF3CDAB8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_B115F84A6CE694968B1CC6F6BF3C0C23" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_DeferredRevenueCurrent_B115F84A6CE694968B1CC6F6BF3C0C23" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AccruedClinicalTrialsCurrent" xlink:label="loc_opk_AccruedClinicalTrialsCurrent_E7E2DC5B05B6F8177994C6F6BF3CC640" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_opk_AccruedClinicalTrialsCurrent_E7E2DC5B05B6F8177994C6F6BF3CC640" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_D9F583981C4455473C41C6F6BF3D7622" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_D9F583981C4455473C41C6F6BF3D7622" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_5BEBAB03FA15708BD94BC6F6BF3DAFAD" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_5BEBAB03FA15708BD94BC6F6BF3DAFAD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" xlink:label="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_53EFB7F682CDC941D7D9C6F6BF3DC3AA" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_53EFB7F682CDC941D7D9C6F6BF3DC3AA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationLiabilityCurrent_EA302623DFA965217AD6C6F6BF3D8C20" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_opk_BusinessCombinationContingentConsiderationLiabilityCurrent_EA302623DFA965217AD6C6F6BF3D8C20" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_81DE186F1084ECB4E099C6F6BF3D28EB" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_81DE186F1084ECB4E099C6F6BF3D28EB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_56811B046705FFA3A692C6F6BF3DE984" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A8A2790A4E702695B29CC6F6BF3C434E" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_56811B046705FFA3A692C6F6BF3DE984" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_97579667712ABF0DB5DFC6F6BF3B4347" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationContingentConsiderationLiabilityNoncurrent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationLiabilityNoncurrent_9C8C430B5917B1BC1D9AC6F6BF3D9D8E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:to="loc_opk_BusinessCombinationContingentConsiderationLiabilityNoncurrent_9C8C430B5917B1BC1D9AC6F6BF3D9D8E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_7E7E8A3E0780914D8CE4C6F6BF3DE60C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_7E7E8A3E0780914D8CE4C6F6BF3DE60C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_4A4045DE75BFEE2CE0BAC6F6BF3D2F12" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_4A4045DE75BFEE2CE0BAC6F6BF3D2F12" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_A1128F4AF6648EEF9C27C6F6BF3DD561" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:to="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_A1128F4AF6648EEF9C27C6F6BF3DD561" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_60678B5F233B2D2EBF71C6F6BF3DF4EC" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_391CC47C659BAB274CB2C6F6BF3D1501" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_60678B5F233B2D2EBF71C6F6BF3DF4EC" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails1" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_95B518F4183B5A807FD0BCB9442A4074" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_D3F85042D65C00A19448BCB94428CCE9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_95B518F4183B5A807FD0BCB9442A4074" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_D3F85042D65C00A19448BCB94428CCE9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_6F3F9ADADAD54ED79D2ABCB9442851F4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_D3F85042D65C00A19448BCB94428CCE9" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_6F3F9ADADAD54ED79D2ABCB9442851F4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6F3F9ADADAD54ED79D2ABCB9442851F4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6F3F9ADADAD54ED79D2ABCB9442851F4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoChileMember" xlink:label="loc_opk_OpkoChileMember_A2EAD1B26A295D392B97BCB94428FA16" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OpkoChileMember_A2EAD1B26A295D392B97BCB94428FA16" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ExaktaOpkoMember" xlink:label="loc_opk_ExaktaOpkoMember_881A282DDF8820564C41BCB944288AD3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_ExaktaOpkoMember_881A282DDF8820564C41BCB944288AD3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CurnaAcquisitionMember" xlink:label="loc_opk_CurnaAcquisitionMember_DF0749EA2E3A5031459ABCB944283516" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_CurnaAcquisitionMember_DF0749EA2E3A5031459ABCB944283516" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoDiagnosticsAcquisitionMember" xlink:label="loc_opk_OpkoDiagnosticsAcquisitionMember_399388BE312BF2B53011BCB944298661" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OpkoDiagnosticsAcquisitionMember_399388BE312BF2B53011BCB944298661" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FinetechAcquisitionMember" xlink:label="loc_opk_FinetechAcquisitionMember_AEEBD570EE41F91B8D5DBCB94429B865" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_FinetechAcquisitionMember_AEEBD570EE41F91B8D5DBCB94429B865" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_F3B109ACF6FC9DBF9E69BCB94429824A" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OPKOHealthEuropeMember_F3B109ACF6FC9DBF9E69BCB94429824A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOLabMember" xlink:label="loc_opk_OPKOLabMember_D3690A337D81136D43F2BCB944298290" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OPKOLabMember_D3690A337D81136D43F2BCB944298290" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_91837DF9F794D5783164BCB94429A122" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_SciVacMember_91837DF9F794D5783164BCB94429A122" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBrazilMember" xlink:label="loc_opk_OPKOBrazilMember_6D831CEE4BC479EAF070BCB94429E3D9" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OPKOBrazilMember_6D831CEE4BC479EAF070BCB94429E3D9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_F09F7BFB784AFD3F89AFBCB944297A50" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OPKORenalMember_F09F7BFB784AFD3F89AFBCB944297A50" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PROLORMember" xlink:label="loc_opk_PROLORMember_C06FE4FF298B6CE90138BCB9442928B0" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_PROLORMember_C06FE4FF298B6CE90138BCB9442928B0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOUruguayLtda.Member" xlink:label="loc_opk_OPKOUruguayLtda.Member_FD10D628A4DB9FA33F71BCB9D08D17F0" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D05AA0605440AC2DAA26BCB94428C154" xlink:to="loc_opk_OPKOUruguayLtda.Member_FD10D628A4DB9FA33F71BCB9D08D17F0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_553AB9E25EED1E5851E4BCB944296ADD" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_D3F85042D65C00A19448BCB94428CCE9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_553AB9E25EED1E5851E4BCB944296ADD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_553AB9E25EED1E5851E4BCB944296ADD" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_553AB9E25EED1E5851E4BCB944296ADD" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_4DC0278AED304A965477BCB94429EC03" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_4DC0278AED304A965477BCB94429EC03" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_032D44300E84508743CBBCB944291147" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_032D44300E84508743CBBCB944291147" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_85CA29FF367D803BD993BCB94429BD63" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_CustomerRelationshipsMember_85CA29FF367D803BD993BCB94429BD63" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_9D3A0D205BAB47FC12F6BCB9442A9C38" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_ProductMember_9D3A0D205BAB47FC12F6BCB9442A9C38" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CovenantsNotToCompeteMember" xlink:label="loc_opk_CovenantsNotToCompeteMember_B0E6E02F26DD7B18521DBCB9442AE77A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_opk_CovenantsNotToCompeteMember_B0E6E02F26DD7B18521DBCB9442AE77A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TradeNamesMember" xlink:label="loc_us-gaap_TradeNamesMember_A458927A9F2D1DCDBA37BCB9442A4A64" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_TradeNamesMember_A458927A9F2D1DCDBA37BCB9442A4A64" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_F8077885A7C0C78EF9F8BCB9442A3D99" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A6688B95AB24102292FCBCB9442986E9" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_F8077885A7C0C78EF9F8BCB9442A3D99" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract_7E3945080DB49C4FE15DBCB9442A8066" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_95B518F4183B5A807FD0BCB9442A4074" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract_7E3945080DB49C4FE15DBCB9442A8066" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_78266690AE747F2CE8ACBCB9442AA408" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract_7E3945080DB49C4FE15DBCB9442A8066" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_78266690AE747F2CE8ACBCB9442AA408" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_FAF099577ECDD667F7B2BCB9442AB6E5" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract_7E3945080DB49C4FE15DBCB9442A8066" xlink:to="loc_us-gaap_Goodwill_FAF099577ECDD667F7B2BCB9442AB6E5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_17348D4EB81236F92DB6BCB9442A92A6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwillAbstract_7E3945080DB49C4FE15DBCB9442A8066" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_17348D4EB81236F92DB6BCB9442A92A6" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAndQualifyingAccountsDisclosureLineItems" xlink:label="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureLineItems_223EDAF34C1755A695CFB2B5E4814111" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAndQualifyingAccountsDisclosureTable" xlink:label="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureTable_04098EEF6A499704526DB2B5E4811119" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureLineItems_223EDAF34C1755A695CFB2B5E4814111" xlink:to="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureTable_04098EEF6A499704526DB2B5E4811119" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_14F53D4DF44F9440FCEDB2B5E481D3AE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureTable_04098EEF6A499704526DB2B5E4811119" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_14F53D4DF44F9440FCEDB2B5E481D3AE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_14F53D4DF44F9440FCEDB2B5E481D3AE" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_14F53D4DF44F9440FCEDB2B5E481D3AE" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsMember" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsMember_239206647CDABECA70DBB2B5E48102DF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsMember_239206647CDABECA70DBB2B5E48102DF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryValuationReserveMember" xlink:label="loc_us-gaap_InventoryValuationReserveMember_DFE3EB9B0EBEA3BED37AB2B5E481A97D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA" xlink:to="loc_us-gaap_InventoryValuationReserveMember_DFE3EB9B0EBEA3BED37AB2B5E481A97D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember" xlink:label="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_DE3766956DEE7AA3B2EBB2B5E48199FE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_9F9FCB4E186564D9C4B1B2B5E48172FA" xlink:to="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_DE3766956DEE7AA3B2EBB2B5E48199FE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAndQualifyingAccountsDisclosureLineItems_223EDAF34C1755A695CFB2B5E4814111" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesBalance" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_1D6D89F33F1CE5CBEE4DB2B5E4827000" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_1D6D89F33F1CE5CBEE4DB2B5E4827000" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_A2D26156B09DBC34D0EEB2B5E4828006" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_A2D26156B09DBC34D0EEB2B5E4828006" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDeductions" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_7E865E4E5FDB21BF1604B2B5E4825D26" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_7E865E4E5FDB21BF1604B2B5E4825D26" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_1EBA29AE3DA54BCADF91B2B5E482E12A" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_D7FCD89BE5FE916C497EB2B5E4822974" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_1EBA29AE3DA54BCADF91B2B5E482E12A" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails3" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillLineItems" xlink:label="loc_us-gaap_GoodwillLineItems_F352BC35B6DA03B344AA7685CDDF7751" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfGoodwillTable" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_8BC309042F32CFF20A4F7685CDDEC6F7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_F352BC35B6DA03B344AA7685CDDF7751" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_8BC309042F32CFF20A4F7685CDDEC6F7" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_A1F6E273256C6EE5E4057685CDDEA198" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_8BC309042F32CFF20A4F7685CDDEC6F7" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_A1F6E273256C6EE5E4057685CDDEA198" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_A1F6E273256C6EE5E4057685CDDEA198" xlink:to="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_A1F6E273256C6EE5E4057685CDDEA198" xlink:to="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_1FF964AD3351E7118E147685CDDFEEB1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC" xlink:to="loc_opk_PharmaceuticalMember_1FF964AD3351E7118E147685CDDFEEB1" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_5A59A4BBE81F32D24F637685CDDFA360" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_EEF7EC4733CB53B77DB77685CDDFAFBC" xlink:to="loc_opk_DiagnosticsMember_5A59A4BBE81F32D24F637685CDDFA360" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_6D5C8791333CDE6961A27685CDDFCFF4" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_8BC309042F32CFF20A4F7685CDDEC6F7" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_6D5C8791333CDE6961A27685CDDFCFF4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6D5C8791333CDE6961A27685CDDFCFF4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6D5C8791333CDE6961A27685CDDFCFF4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_3EBAA75854C825DD939A7685CDDFFA6F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_CURNAMember_3EBAA75854C825DD939A7685CDDFFA6F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ExaktaOpkoMember" xlink:label="loc_opk_ExaktaOpkoMember_85E668BA51A91630E56D7685CDDF2730" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_ExaktaOpkoMember_85E668BA51A91630E56D7685CDDF2730" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoChileMember" xlink:label="loc_opk_OpkoChileMember_2E2F00F684050CD09D957685CDDF34C6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_OpkoChileMember_2E2F00F684050CD09D957685CDDF34C6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_129D552514BD61175AC77685CDDF990D" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_OPKOHealthEuropeMember_129D552514BD61175AC77685CDDF990D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_E3D79AAB8F49939F93BE7685CDDF76D7" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_FineTechMember_E3D79AAB8F49939F93BE7685CDDF76D7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SciGenMember" xlink:label="loc_opk_SciGenMember_E7B268D29E929F021CA07685CDDFFE61" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_SciGenMember_E7B268D29E929F021CA07685CDDFFE61" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_BE104CC21453657FB50A7685CDDFC187" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_OPKORenalMember_BE104CC21453657FB50A7685CDDFC187" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PROLORMember" xlink:label="loc_opk_PROLORMember_06D22BDB6E6D8C97CAEA7685CDDFE33E" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_PROLORMember_06D22BDB6E6D8C97CAEA7685CDDFE33E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ClarosMember" xlink:label="loc_opk_ClarosMember_DDD1C6956509DF0CCF9F7685CDDFA838" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_ClarosMember_DDD1C6956509DF0CCF9F7685CDDFA838" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_9B4A762D66B0E2F02BF77685CDDF523B" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_OpkoDiagnosticsMember_9B4A762D66B0E2F02BF77685CDDF523B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOLabMember" xlink:label="loc_opk_OPKOLabMember_508BE31C813C338873A97685CDDF3171" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C6F1361E0FCF600C92847685CDDFD73C" xlink:to="loc_opk_OPKOLabMember_508BE31C813C338873A97685CDDF3171" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillRollForward" xlink:label="loc_us-gaap_GoodwillRollForward_20EDCCEDD49D99732EAF7685CDDFCFC4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_F352BC35B6DA03B344AA7685CDDF7751" xlink:to="loc_us-gaap_GoodwillRollForward_20EDCCEDD49D99732EAF7685CDDFCFC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_C7FE23D509E74BF5F6567685CDDF8187" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_20EDCCEDD49D99732EAF7685CDDFCFC4" xlink:to="loc_us-gaap_Goodwill_C7FE23D509E74BF5F6567685CDDF8187" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAcquiredDuringPeriod" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_7E71F163C8584B14F9027685CDDF241D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_20EDCCEDD49D99732EAF7685CDDFCFC4" xlink:to="loc_us-gaap_GoodwillAcquiredDuringPeriod_7E71F163C8584B14F9027685CDDF241D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillOtherChanges" xlink:label="loc_us-gaap_GoodwillOtherChanges_5B58601E9B58361AA7897685CDDF409B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_20EDCCEDD49D99732EAF7685CDDFCFC4" xlink:to="loc_us-gaap_GoodwillOtherChanges_5B58601E9B58361AA7897685CDDF409B" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/CondensedConsolidatedStatementOfEquity" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_549B4273920E974B7F07C8A299A0101A" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_549B4273920E974B7F07C8A299A0101A" xlink:to="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_8E2017040094398D7FE8C8A2999EF8F2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:to="loc_us-gaap_StatementClassOfStockAxis_8E2017040094398D7FE8C8A2999EF8F2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_72A7AB47634067B98D51C8A2999E1C57_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8E2017040094398D7FE8C8A2999EF8F2" xlink:to="loc_us-gaap_ClassOfStockDomain_72A7AB47634067B98D51C8A2999E1C57_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_72A7AB47634067B98D51C8A2999E1C57" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8E2017040094398D7FE8C8A2999EF8F2" xlink:to="loc_us-gaap_ClassOfStockDomain_72A7AB47634067B98D51C8A2999E1C57" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_4817386838A2229700BDC8A2999EC42B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_72A7AB47634067B98D51C8A2999E1C57" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_4817386838A2229700BDC8A2999EC42B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_1158E951B227A3E39D92C8A2999E30CA" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:to="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_1158E951B227A3E39D92C8A2999E30CA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_1158E951B227A3E39D92C8A2999E30CA" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_1158E951B227A3E39D92C8A2999E30CA" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_27C3F734A808E8DBC14CC8A2999F8AD7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_27C3F734A808E8DBC14CC8A2999F8AD7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_C5AA68D622BEE6A60267C8A2999F67A9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_8AA069FCE14D3C901955C8A2999E3D8B" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_C5AA68D622BEE6A60267C8A2999F67A9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_B5EF95F8E3D446E83B7AC8A2999FB7BB" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_B5EF95F8E3D446E83B7AC8A2999FB7BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_B5EF95F8E3D446E83B7AC8A2999FB7BB" xlink:to="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_B5EF95F8E3D446E83B7AC8A2999FB7BB" xlink:to="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_780A46A6096A6B2DA442C8A2999F2883" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_CommonStockMember_780A46A6096A6B2DA442C8A2999F2883" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_96F5BD299CB8AE844AA7C8A2999FFE50" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_TreasuryStockMember_96F5BD299CB8AE844AA7C8A2999FFE50" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_5B3BFEA8633F208E208DC8A2999F5972" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_5B3BFEA8633F208E208DC8A2999F5972" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_30956910FCE60BE67242C8A2999F2D33" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_30956910FCE60BE67242C8A2999F2D33" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_317322A11012B75914FEC8A2999F414E" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_RetainedEarningsMember_317322A11012B75914FEC8A2999F414E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_E4A09571107F57BAE25AC8A2999FADE3" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_CDDC1E4A2CB14EF0216AC8A2999FC713" xlink:to="loc_us-gaap_NoncontrollingInterestMember_E4A09571107F57BAE25AC8A2999FADE3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_1C244EEFA2F4FA38E229C8A2999FB967" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4C882F04E8AC945F9873C8A2999ECB3A" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_1C244EEFA2F4FA38E229C8A2999FB967" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1C244EEFA2F4FA38E229C8A2999FB967" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1C244EEFA2F4FA38E229C8A2999FB967" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOUruguayLtda.Member" xlink:label="loc_opk_OPKOUruguayLtda.Member_1D98605E93087FB5B816C8A2999FCD3E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKOUruguayLtda.Member_1D98605E93087FB5B816C8A2999FCD3E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_InspiroMedicalLtd.Member" xlink:label="loc_opk_InspiroMedicalLtd.Member_5CE3A7607D73314716E3C8A2999F1B89" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_InspiroMedicalLtd.Member_5CE3A7607D73314716E3C8A2999F1B89" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_AE3C25F5426D4D1984C7C8A2999F18FE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKOHealthEuropeMember_AE3C25F5426D4D1984C7C8A2999F18FE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBrazilMember" xlink:label="loc_opk_OPKOBrazilMember_BE2672BAE3EAC51F1913C8A2999FFF7E" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKOBrazilMember_BE2672BAE3EAC51F1913C8A2999FFF7E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_25047EA6DA725058D6C4C8A2999F6227" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKORenalMember_25047EA6DA725058D6C4C8A2999F6227" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_3F2339A48FA0918EA3DBC8A2999FA15A" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKOBiologicsMember_3F2339A48FA0918EA3DBC8A2999FA15A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOLabMember" xlink:label="loc_opk_OPKOLabMember_D10FA06B81743FD414ECC8A299A07E1E" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D455C4305B1F259734BAC8A2999F20AE" xlink:to="loc_opk_OPKOLabMember_D10FA06B81743FD414ECC8A299A07E1E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_549B4273920E974B7F07C8A299A0101A" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_52A28BD2DE6159D0EFF8C8A299A052E1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_52A28BD2DE6159D0EFF8C8A299A052E1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_777469EF287FF0B695C4C8A299A03F4A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_SharesOutstanding_777469EF287FF0B695C4C8A299A03F4A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_FE3FFB11D78989090DA3C8A299A03FE6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_FE3FFB11D78989090DA3C8A299A03FE6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_99E6D75844D366012839C8A299A09946" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_99E6D75844D366012839C8A299A09946" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9382F455516A2F37068AC8A299A03BF9" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9382F455516A2F37068AC8A299A03BF9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodValueWarrantsExercised" xlink:label="loc_opk_StockIssuedDuringPeriodValueWarrantsExercised_BD16F7BCAF9F66B595E7C8A299A07E8E" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodValueWarrantsExercised_BD16F7BCAF9F66B595E7C8A299A07E8E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodSharesWarrantsExercised" xlink:label="loc_opk_StockIssuedDuringPeriodSharesWarrantsExercised_665178FB0E2F7A9C73A8C8A299A09A52" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodSharesWarrantsExercised_665178FB0E2F7A9C73A8C8A299A09A52" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AdjustmentOfCommonStockValue" xlink:label="loc_opk_AdjustmentOfCommonStockValue_9A6298C55D1CD14D9C52C8A299A009C5" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_AdjustmentOfCommonStockValue_9A6298C55D1CD14D9C52C8A299A009C5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AdjustmentOfCommonStockShares" xlink:label="loc_opk_AdjustmentOfCommonStockShares_486608158AC061FB2A77C8A299A093BD" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_AdjustmentOfCommonStockShares_486608158AC061FB2A77C8A299A093BD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="loc_us-gaap_DividendsPreferredStockCash_FC1414C62E2D7939C442C8A299A033DD" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_DividendsPreferredStockCash_FC1414C62E2D7939C442C8A299A033DD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_BEF02BF26642F2A90B5FC8A299A07071" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_BEF02BF26642F2A90B5FC8A299A07071" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_97434513CDC88EFDAFEAC8A299A0426D" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_97434513CDC88EFDAFEAC8A299A0426D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_B72490BD863619EA8347C8A299A06CAA" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_B72490BD863619EA8347C8A299A06CAA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_53DE25A289E5DA5F8039C8A299A04EB3" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_53DE25A289E5DA5F8039C8A299A04EB3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodValueDeferredPayment" xlink:label="loc_opk_StockIssuedDuringPeriodValueDeferredPayment_9B43CD6ACC1128F74490C8A299A003E8" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodValueDeferredPayment_9B43CD6ACC1128F74490C8A299A003E8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodShareContingentConsideration" xlink:label="loc_opk_StockIssuedDuringPeriodShareContingentConsideration_60197671A1FB39FF240DC8A299A0D1A5" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodShareContingentConsideration_60197671A1FB39FF240DC8A299A0D1A5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodValueContingentConsideration" xlink:label="loc_opk_StockIssuedDuringPeriodValueContingentConsideration_CBEF29626CC60AA43319C8A299A13933" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodValueContingentConsideration_CBEF29626CC60AA43319C8A299A13933" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodShareDeferredPayment" xlink:label="loc_opk_StockIssuedDuringPeriodShareDeferredPayment_E7708940E549646FF42AC8A299A19A9B" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_opk_StockIssuedDuringPeriodShareDeferredPayment_E7708940E549646FF42AC8A299A19A9B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_63AD17BD5D68FFE24C7CC8A299A106BA" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_NetIncomeLoss_63AD17BD5D68FFE24C7CC8A299A106BA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_16FBCE2E69CA305BF1F3C8A299A14D67" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_16FBCE2E69CA305BF1F3C8A299A14D67" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_00EF76C2DF541C22C995C8A299A13328" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A3302E49761CE9E3BE1CC8A299A07386" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_00EF76C2DF541C22C995C8A299A13328" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CondensedConsolidatedStatementOfShareholdersEquityUnauditedParenthetical" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_C7C3F4E625BFC8455388B2B5E4ED1777" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_177E2AC5A100A54310C9B2B5E4ED1C11" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_C7C3F4E625BFC8455388B2B5E4ED1777" xlink:to="loc_us-gaap_StatementTable_177E2AC5A100A54310C9B2B5E4ED1C11" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_8696D23A3DCF6B9668A0B2B5E4ED3734" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_177E2AC5A100A54310C9B2B5E4ED1C11" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_8696D23A3DCF6B9668A0B2B5E4ED3734" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8696D23A3DCF6B9668A0B2B5E4ED3734" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8696D23A3DCF6B9668A0B2B5E4ED3734" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_FD2946857166EB3005E5B2B5E4ED44B8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_OPKOHealthEuropeMember_FD2946857166EB3005E5B2B5E4ED44B8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_InspiroMedicalLtd.Member" xlink:label="loc_opk_InspiroMedicalLtd.Member_BFB8BFD2B0414ABAD3C0B2C397E26F4A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_InspiroMedicalLtd.Member_BFB8BFD2B0414ABAD3C0B2C397E26F4A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBrazilMember" xlink:label="loc_opk_OPKOBrazilMember_91D28D485E594E4B4B93B2B5E4ED5136" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_OPKOBrazilMember_91D28D485E594E4B4B93B2B5E4ED5136" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_03CA3D0A9F364CF378FAB2B5E4EDE43F" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_OPKORenalMember_03CA3D0A9F364CF378FAB2B5E4EDE43F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_8F5ECCB8114906E34252B2B5E4ED806B" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_OPKOBiologicsMember_8F5ECCB8114906E34252B2B5E4ED806B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOLabMember" xlink:label="loc_opk_OPKOLabMember_74941E8092B53EF32A68B2B5E4ED64C2" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D3F2D04A23746E2B35D3B2B5E4ED1FA4" xlink:to="loc_opk_OPKOLabMember_74941E8092B53EF32A68B2B5E4ED64C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_BCEB1385AA39337A4A8DB2B5E4ED459D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_C7C3F4E625BFC8455388B2B5E4ED1777" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_BCEB1385AA39337A4A8DB2B5E4ED459D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_502E25A38D6B19DAB00AB2B5E4EDB78C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_C7C3F4E625BFC8455388B2B5E4ED1777" xlink:to="loc_us-gaap_SharePrice_502E25A38D6B19DAB00AB2B5E4EDB78C" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/CondensedConsolidatedStatementsOfCashFlowsUnauditedParenthetical" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_CB3A652AA0A52B546191935458C1D7D5" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_CE269CFE40FB38F6CF0C935458C0640C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_CB3A652AA0A52B546191935458C1D7D5" xlink:to="loc_us-gaap_StatementTable_CE269CFE40FB38F6CF0C935458C0640C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_98614CC360585AFB0FE7935458C0AE33" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_CE269CFE40FB38F6CF0C935458C0640C" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_98614CC360585AFB0FE7935458C0AE33" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_FF661C732B2DF402D81A935458C050A8_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_98614CC360585AFB0FE7935458C0AE33" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_FF661C732B2DF402D81A935458C050A8_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_FF661C732B2DF402D81A935458C050A8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_98614CC360585AFB0FE7935458C0AE33" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_FF661C732B2DF402D81A935458C050A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_27B48EDDED67F836957F935458C0D53A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_FF661C732B2DF402D81A935458C050A8" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_27B48EDDED67F836957F935458C0D53A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_2EFCC26ADA75E83B8FF8935458C16128" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_CE269CFE40FB38F6CF0C935458C0640C" xlink:to="loc_us-gaap_DebtInstrumentAxis_2EFCC26ADA75E83B8FF8935458C16128" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_B7E1A80ED987F667E396935458C17A47_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_2EFCC26ADA75E83B8FF8935458C16128" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_B7E1A80ED987F667E396935458C17A47_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_B7E1A80ED987F667E396935458C17A47" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_2EFCC26ADA75E83B8FF8935458C16128" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_B7E1A80ED987F667E396935458C17A47" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_EE57D33B0C671538272D935458C18CC1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_B7E1A80ED987F667E396935458C17A47" xlink:to="loc_opk_NotesDueFebruary12033Member_EE57D33B0C671538272D935458C18CC1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_C4B775ED3EE88E2ACD43935458C105D3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_CB3A652AA0A52B546191935458C1D7D5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_C4B775ED3EE88E2ACD43935458C105D3" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/ConsolidatedBalanceSheetsUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/ConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_C1AAEDC32FD309D87E96CBC588B12CAD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_StatementTable_C1AAEDC32FD309D87E96CBC588B12CAD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_3276FE45C88E7851E245CBC588B1416E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_C1AAEDC32FD309D87E96CBC588B12CAD" xlink:to="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_3276FE45C88E7851E245CBC588B1416E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_3276FE45C88E7851E245CBC588B1416E" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_3276FE45C88E7851E245CBC588B1416E" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConversionofSeriesDPreferredStockMember" xlink:label="loc_opk_ConversionofSeriesDPreferredStockMember_37F7D9B5DCFB6A7CA726CBC588B1EB9E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F" xlink:to="loc_opk_ConversionofSeriesDPreferredStockMember_37F7D9B5DCFB6A7CA726CBC588B1EB9E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConversionofSeniorNotesMember" xlink:label="loc_opk_ConversionofSeniorNotesMember_99C850F3556F860B115BCBC588B12FFA" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_5CB90E445213A8117C27CBC588B1790F" xlink:to="loc_opk_ConversionofSeniorNotesMember_99C850F3556F860B115BCBC588B12FFA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_605D519BCFA8EC73DFABCBC588B10B1B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_C1AAEDC32FD309D87E96CBC588B12CAD" xlink:to="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_605D519BCFA8EC73DFABCBC588B10B1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNameDomain" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_605D519BCFA8EC73DFABCBC588B10B1B" xlink:to="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNameDomain" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_605D519BCFA8EC73DFABCBC588B10B1B" xlink:to="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOProlorMember" xlink:label="loc_opk_OPKOProlorMember_35F06A0E6B60969B2ED8CBC588B1D032" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKOProlorMember_35F06A0E6B60969B2ED8CBC588B1D032" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORentalMember" xlink:label="loc_opk_OPKORentalMember_DE7AA007FCFD1049F0D6CBC588B16C34" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKORentalMember_DE7AA007FCFD1049F0D6CBC588B16C34" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBrazilMember" xlink:label="loc_opk_OPKOBrazilMember_FFA90BA579F25ABE6109CBC588B10458" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKOBrazilMember_FFA90BA579F25ABE6109CBC588B10458" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOSpainMember" xlink:label="loc_opk_OPKOSpainMember_25AA295C6595D334E5E2CBC588B17ADA" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKOSpainMember_25AA295C6595D334E5E2CBC588B17ADA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOLabMember" xlink:label="loc_opk_OPKOLabMember_10D6EC96126E764784A7CBC588B1AE2B" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKOLabMember_10D6EC96126E764784A7CBC588B1AE2B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOUruguayLtda.Member" xlink:label="loc_opk_OPKOUruguayLtda.Member_BA11942D929A6BFFBBBFCBC588B27357" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_OPKOUruguayLtda.Member_BA11942D929A6BFFBBBFCBC588B27357" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_InspiroMedicalLtd.Member" xlink:label="loc_opk_InspiroMedicalLtd.Member_77814555AB3C3F1ABE34CBC588B22B09" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_94177A95657C73A55876CBC588B16491" xlink:to="loc_opk_InspiroMedicalLtd.Member_77814555AB3C3F1ABE34CBC588B22B09" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_226E74EC377355F181C8CBC588B29C21" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_226E74EC377355F181C8CBC588B29C21" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_3BD501471C6101322207CBC588B273DB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_226E74EC377355F181C8CBC588B29C21" xlink:to="loc_us-gaap_ProfitLoss_3BD501471C6101322207CBC588B273DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_226E74EC377355F181C8CBC588B29C21" xlink:to="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_DA92504177C87DBF67A7CBC588B29A2C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_DA92504177C87DBF67A7CBC588B29A2C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaidInKindInterest" xlink:label="loc_us-gaap_PaidInKindInterest_3A9A9FA2FC1CC5AB84C6CBC588B2C63B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_PaidInKindInterest_3A9A9FA2FC1CC5AB84C6CBC588B2C63B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_0D31F9DA07F4BB5864D6CBC588B2DC1B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_0D31F9DA07F4BB5864D6CBC588B2DC1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_1622F39669CB6CCF497CCBC588B2C7D4" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_1622F39669CB6CCF497CCBC588B2C7D4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_DCC89E8AB84B0AA6CFA8CBC588B2A1A4" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_ShareBasedCompensation_DCC89E8AB84B0AA6CFA8CBC588B2A1A4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_272F14A95FFFA0FB43C4CBC588B2E9ED" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_272F14A95FFFA0FB43C4CBC588B2E9ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryWriteDown" xlink:label="loc_us-gaap_InventoryWriteDown_1BEE68BA179380C077F5CBC588B227B9" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_InventoryWriteDown_1BEE68BA179380C077F5CBC588B227B9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromReceiptOfEquity" xlink:label="loc_opk_RevenueFromReceiptOfEquity_51221AF201FB85C97EB3CBC588B24FD4" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_opk_RevenueFromReceiptOfEquity_51221AF201FB85C97EB3CBC588B24FD4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_2A9A6AD0DED11B365885CBC588B2E471" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_GainLossOnSaleOfInvestments_2A9A6AD0DED11B365885CBC588B2E471" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_E943C02FCC378D2CBEF5CBC588B352B1" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_E943C02FCC378D2CBEF5CBC588B352B1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_C70EDDF12C6F91DF5283CBC588B31991" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_C70EDDF12C6F91DF5283CBC588B31991" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73A0BE43AC2590CDEFCFCBC588B36CC6" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73A0BE43AC2590CDEFCFCBC588B36CC6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentInProcess" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_6E873225E534B12F5400CBC588B3528D" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_ResearchAndDevelopmentInProcess_6E873225E534B12F5400CBC588B3528D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_ABBD75E166B04E1E451ECBC588B32A2C" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_ABBD75E166B04E1E451ECBC588B32A2C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_CD0497A4A1C99A72E3EFCBC588B314FB" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_CD0497A4A1C99A72E3EFCBC588B314FB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_CACDF049B5D32FBE6112CBC588B2606A" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_108E74B348B0F4500D42CBC588B3F22F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_108E74B348B0F4500D42CBC588B3F22F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_59C397FFB1B480D2DEFCCBC588B32BFC" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_59C397FFB1B480D2DEFCCBC588B32BFC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5D8A1B502F8C93E50756CBC588B37402" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5D8A1B502F8C93E50756CBC588B37402" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_F5386B4BD53B57E4E4C4CBC588B30C75" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_F5386B4BD53B57E4E4C4CBC588B30C75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_309280DD4A39928683B9CBC588B3A29E" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_309280DD4A39928683B9CBC588B3A29E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_C40A0F8CA3D5F41DDEF9CBC588B367AD" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_C40A0F8CA3D5F41DDEF9CBC588B367AD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_8D6CF25F5A41FEC2B954CBC588B3BC14" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_672A6F21304997DE3AE0CBC588B3829A" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_8D6CF25F5A41FEC2B954CBC588B3BC14" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_76349CEFC994EF94B067CBC588B315A7" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_226E74EC377355F181C8CBC588B29C21" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_76349CEFC994EF94B067CBC588B315A7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_F65A5B8167EEFE1D1079CBC588B38A65" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_F65A5B8167EEFE1D1079CBC588B38A65" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_EBA955816B78A30F33E0CBC588B47898" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_EBA955816B78A30F33E0CBC588B47898" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_18379D72D9195219D3FDCBC588B4D970" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_18379D72D9195219D3FDCBC588B4D970" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_79179E20BC11FF807486CBC588B41874" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_79179E20BC11FF807486CBC588B41874" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_6F5378F972826AADF189CBC588B4EE52" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_6F5378F972826AADF189CBC588B4EE52" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_E34558FA2CD64FE9B5F8CBC588B40EEF" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_E34558FA2CD64FE9B5F8CBC588B40EEF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_5F5FF0852EF631BE04AFCBC588B416D8" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_5F5FF0852EF631BE04AFCBC588B416D8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_306C088224ACB553A433CBC588B4A5E1" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_E23C2DB9E06BCD4C609DCBC588B3A103" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_306C088224ACB553A433CBC588B4A5E1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_A3021012BA3F3034C813CBC588B422D6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_A3021012BA3F3034C813CBC588B422D6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_9E1B30838C9B88190227CBC588B4829B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_9E1B30838C9B88190227CBC588B4829B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_8263A349B732F8AB42A7CBC588B4FC80" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_8263A349B732F8AB42A7CBC588B4FC80" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromPaymentsToMinorityShareholders" xlink:label="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_8DBE85956513A7924CA4CBC588B4E1E0" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_8DBE85956513A7924CA4CBC588B4E1E0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsForPreviousAcquisition" xlink:label="loc_us-gaap_PaymentsForPreviousAcquisition_B2865FBDC35885383D1DCBC588B4CFD9" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_PaymentsForPreviousAcquisition_B2865FBDC35885383D1DCBC588B4CFD9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_5C83E43CBD4EB3BD9E20CBC588B44D6E" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_ProceedsFromLinesOfCredit_5C83E43CBD4EB3BD9E20CBC588B44D6E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_D96AE7F86CA4D9352EDFCBC588B47E8A" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_D96AE7F86CA4D9352EDFCBC588B47E8A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_B5B71519B7E2145665CFCBC588B5CE05" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_03FF976ABC9B75945A3DCBC588B4033C" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_B5B71519B7E2145665CFCBC588B5CE05" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_979A0E680EE7A4E6CD54CBC588B5D0D5" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_979A0E680EE7A4E6CD54CBC588B5D0D5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_D02EC8BE795283734636CBC588B5282A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_D02EC8BE795283734636CBC588B5282A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_8212CC74D396F144F964CBC588B58E6C" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_8212CC74D396F144F964CBC588B58E6C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_743F2279F25AF903E84ACBC588B2D438" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_9D7398EC0F4E1D68ED7FCBC588B53E1E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:to="loc_us-gaap_InterestPaid_9D7398EC0F4E1D68ED7FCBC588B53E1E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_7E2517D857E35766E906CBC588B51250" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_7E2517D857E35766E906CBC588B51250" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromSaleOfIntellectualProperty" xlink:label="loc_opk_RevenueFromSaleOfIntellectualProperty_F22ECF1F279DEA9D6CAECBC588B5C7DB" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:to="loc_opk_RevenueFromSaleOfIntellectualProperty_F22ECF1F279DEA9D6CAECBC588B5C7DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_4A119F2462DF36915648CBC588B5CF83" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_4A119F2462DF36915648CBC588B5CF83" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_3B745B41956AB61E913FCBC588B5E399" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B15D7ABB172C9C86A03FCBC588B58092" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_3B745B41956AB61E913FCBC588B5E399" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockAmountIssued1" xlink:label="loc_us-gaap_ConversionOfStockAmountIssued1_F6B571893F3B8447B7D6CBC588B53C4C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_3B745B41956AB61E913FCBC588B5E399" xlink:to="loc_us-gaap_ConversionOfStockAmountIssued1_F6B571893F3B8447B7D6CBC588B53C4C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CommonStockWarrantsNetExercised" xlink:label="loc_opk_CommonStockWarrantsNetExercised_6EC425AC669387439FA5CBC588B55F40" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_3B745B41956AB61E913FCBC588B5E399" xlink:to="loc_opk_CommonStockWarrantsNetExercised_6EC425AC669387439FA5CBC588B55F40" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" xlink:label="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_6136FFC9D3DA13C59A73CBC588B56908" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_3B745B41956AB61E913FCBC588B5E399" xlink:to="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_6136FFC9D3DA13C59A73CBC588B56908" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_2474F5B1C33582D76126CBC588B5C0EE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_6136FFC9D3DA13C59A73CBC588B56908" xlink:to="loc_us-gaap_StockIssued1_2474F5B1C33582D76126CBC588B5C0EE" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsOfOperationsUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/Debt" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/DebtFairValueOfEmbeddedDerivativesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_C824E7837C5CAA68C83408B4E76CE2F1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_52ED4F7317D95214863408B4E76BE20B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C824E7837C5CAA68C83408B4E76CE2F1" xlink:to="loc_us-gaap_DebtInstrumentTable_52ED4F7317D95214863408B4E76BE20B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_5667E3B01D4CC3C47DD008B4E76B336E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_52ED4F7317D95214863408B4E76BE20B" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_5667E3B01D4CC3C47DD008B4E76B336E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3F28EB1CC69B8F376D0708B4E76B50E8_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5667E3B01D4CC3C47DD008B4E76B336E" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3F28EB1CC69B8F376D0708B4E76B50E8_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3F28EB1CC69B8F376D0708B4E76B50E8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5667E3B01D4CC3C47DD008B4E76B336E" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3F28EB1CC69B8F376D0708B4E76B50E8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_EA25E74A7E37F221ED7108B4E76C5A6D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_3F28EB1CC69B8F376D0708B4E76B50E8" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_EA25E74A7E37F221ED7108B4E76C5A6D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_32D07BA41E898AC47C6008B4E76CE8EF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C824E7837C5CAA68C83408B4E76CE2F1" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_32D07BA41E898AC47C6008B4E76CE8EF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_E31866A6827FDC3A16D808B4E76CA654" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_32D07BA41E898AC47C6008B4E76CE8EF" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_E31866A6827FDC3A16D808B4E76CA654" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" xlink:label="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_A628EA917CE5ABF39D8A08B4E76C0AA8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_32D07BA41E898AC47C6008B4E76CE8EF" xlink:to="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_A628EA917CE5ABF39D8A08B4E76C0AA8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_E03334B4CBCD6A79AC9A08B4E76CBFA6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_32D07BA41E898AC47C6008B4E76CE8EF" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_E03334B4CBCD6A79AC9A08B4E76CBFA6" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtInputsUsedInLatticeModelDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_6508519F06808BC86BB5935458441D55" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_DebtInstrumentTable_6508519F06808BC86BB5935458441D55" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_7FFA2CFEBAE0F7A7A50B93545844EF65" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6508519F06808BC86BB5935458441D55" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_7FFA2CFEBAE0F7A7A50B93545844EF65" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_22FC83003FDEA693BF929354584440E9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7FFA2CFEBAE0F7A7A50B93545844EF65" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_22FC83003FDEA693BF929354584440E9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_22FC83003FDEA693BF929354584440E9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7FFA2CFEBAE0F7A7A50B93545844EF65" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_22FC83003FDEA693BF929354584440E9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_6B9B6D368D8090F17A49935458445AC4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_22FC83003FDEA693BF929354584440E9" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_6B9B6D368D8090F17A49935458445AC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_8110FFCF367D8422CC5E935458456CDD" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6508519F06808BC86BB5935458441D55" xlink:to="loc_us-gaap_DebtInstrumentAxis_8110FFCF367D8422CC5E935458456CDD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_C711D5DDFE9AA369AEE4935458450402_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_8110FFCF367D8422CC5E935458456CDD" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_C711D5DDFE9AA369AEE4935458450402_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_C711D5DDFE9AA369AEE4935458450402" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_8110FFCF367D8422CC5E935458456CDD" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_C711D5DDFE9AA369AEE4935458450402" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_179A39955904CF22E17293545845A544" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_C711D5DDFE9AA369AEE4935458450402" xlink:to="loc_opk_NotesDueFebruary12033Member_179A39955904CF22E17293545845A544" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_C763ABF499F490736F9F935458456115" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_SharePrice_C763ABF499F490736F9F935458456115" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_4DFDC66C24C333069D9893545845B4A2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_4DFDC66C24C333069D9893545845B4A2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_D970681AAB5C81CA00519354584525CE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_D970681AAB5C81CA00519354584525CE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_5196F13F4259CB69FD3F935458458E4E" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_5196F13F4259CB69FD3F935458458E4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_EB16A9C62511E8890A4C9354584575A5" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_EB16A9C62511E8890A4C9354584575A5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_79461846F29796BD44689354584543AF" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_79461846F29796BD44689354584543AF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsEntityCreditRisk" xlink:label="loc_us-gaap_FairValueInputsEntityCreditRisk_4CFC6B474A035FCCAE43935458455F2B" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_FairValueInputsEntityCreditRisk_4CFC6B474A035FCCAE43935458455F2B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_B3A9271712D5E955584E937C6A75632E" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1B0BDD6E9A959DEE617893545845E495" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_B3A9271712D5E955584E937C6A75632E" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtLinesOfCreditDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_8B4592512D22BFAA212FBCBA6A33E59C" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_C9040B5B1CEC981143FFBCBA6A32F2FD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_8B4592512D22BFAA212FBCBA6A33E59C" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_C9040B5B1CEC981143FFBCBA6A32F2FD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_3C5F33711F57B91FBBD8BCBA6A320A6C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_C9040B5B1CEC981143FFBCBA6A32F2FD" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_3C5F33711F57B91FBBD8BCBA6A320A6C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_3C5F33711F57B91FBBD8BCBA6A320A6C" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_3C5F33711F57B91FBBD8BCBA6A320A6C" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ItauBankMember" xlink:label="loc_opk_ItauBankMember_96108CA6C54EEDFB1782BCBA6A32B4CE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_ItauBankMember_96108CA6C54EEDFB1782BCBA6A32B4CE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BankOfChileMember" xlink:label="loc_opk_BankOfChileMember_B905DEB0E43105579D5DBCBA6A32726D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_BankOfChileMember_B905DEB0E43105579D5DBCBA6A32726D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BiceBankMember" xlink:label="loc_opk_BiceBankMember_1E5C2A1361E647F98A39BCBA6A32D019" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_BiceBankMember_1E5C2A1361E647F98A39BCBA6A32D019" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CorpBancaMember" xlink:label="loc_opk_CorpBancaMember_E65CB6C3DC19698610B5BCBA6A32C0E9" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_CorpBancaMember_E65CB6C3DC19698610B5BCBA6A32C0E9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BbvaBankMember" xlink:label="loc_opk_BbvaBankMember_1ECD92F7F838F71D98FEBCBA6A32AD09" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_BbvaBankMember_1ECD92F7F838F71D98FEBCBA6A32AD09" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PentaBankMember" xlink:label="loc_opk_PentaBankMember_895C26E8B47EAF5E2982BCBA6A326E8C" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_PentaBankMember_895C26E8B47EAF5E2982BCBA6A326E8C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SecurityMember" xlink:label="loc_opk_SecurityMember_9D3F8C384B2B679E7C03BCBA6A32C275" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_SecurityMember_9D3F8C384B2B679E7C03BCBA6A32C275" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BciMember" xlink:label="loc_opk_BciMember_2DF9F07DAD58DF03A3DBBCBA6A33FBAB" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_BciMember_2DF9F07DAD58DF03A3DBBCBA6A33FBAB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EstadoBankMember" xlink:label="loc_opk_EstadoBankMember_D66999BE5456A1F4A78FBCBA6A338DCB" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_EstadoBankMember_D66999BE5456A1F4A78FBCBA6A338DCB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SabadellBankMember" xlink:label="loc_opk_SabadellBankMember_7524B1BC4774FC6E7713BCBA6A3303A8" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_SabadellBankMember_7524B1BC4774FC6E7713BCBA6A3303A8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BilbaoVizcayaBankMember" xlink:label="loc_opk_BilbaoVizcayaBankMember_E2542B2CB0384BCCE4D5BCBA6A33B375" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_BilbaoVizcayaBankMember_E2542B2CB0384BCCE4D5BCBA6A33B375" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SantanderBankMember" xlink:label="loc_opk_SantanderBankMember_3579E39E07467340DBD5BCBA6A3364BF" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_F793B97316A5C455CA06BCBA6A326E3A" xlink:to="loc_opk_SantanderBankMember_3579E39E07467340DBD5BCBA6A3364BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_27A9C0AD362B36B2F756BCBA6A336A7B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_8B4592512D22BFAA212FBCBA6A33E59C" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_27A9C0AD362B36B2F756BCBA6A336A7B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_912E62F9C1F89FC1730EBCBA6A331980" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_8B4592512D22BFAA212FBCBA6A33E59C" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_912E62F9C1F89FC1730EBCBA6A331980" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditFacilityAmountOutstanding" xlink:label="loc_us-gaap_LineOfCreditFacilityAmountOutstanding_0D92D23B890DC684EB11BCBA6A339418" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_8B4592512D22BFAA212FBCBA6A33E59C" xlink:to="loc_us-gaap_LineOfCreditFacilityAmountOutstanding_0D92D23B890DC684EB11BCBA6A339418" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtMortgageNotesAndOtherDebtDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0E851A6B0DE5132F5121944BAB172EE7" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_526B7A17A9FB24B93F9B944BAB16BAFB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0E851A6B0DE5132F5121944BAB172EE7" xlink:to="loc_us-gaap_DebtInstrumentTable_526B7A17A9FB24B93F9B944BAB16BAFB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_8C39D40725D2E625C88A944BAB166120" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_526B7A17A9FB24B93F9B944BAB16BAFB" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_8C39D40725D2E625C88A944BAB166120" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_89637EBA7CB16A53D218944BAB17B19B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8C39D40725D2E625C88A944BAB166120" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_89637EBA7CB16A53D218944BAB17B19B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_89637EBA7CB16A53D218944BAB17B19B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8C39D40725D2E625C88A944BAB166120" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_89637EBA7CB16A53D218944BAB17B19B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_DA10E4D0FAF3CBA0014A944C3930D993" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_89637EBA7CB16A53D218944BAB17B19B" xlink:to="loc_opk_OPKOHealthEuropeMember_DA10E4D0FAF3CBA0014A944C3930D993" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_C76F027FF45257FAC774944BAB17692B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0E851A6B0DE5132F5121944BAB172EE7" xlink:to="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_C76F027FF45257FAC774944BAB17692B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_35A7BB9635564FDE7EF8944BAB174E11" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_C76F027FF45257FAC774944BAB17692B" xlink:to="loc_us-gaap_LongTermDebtCurrent_35A7BB9635564FDE7EF8944BAB174E11" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_E7B77EB42F47973E6447944BAB17091A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_C76F027FF45257FAC774944BAB17692B" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_E7B77EB42F47973E6447944BAB17091A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_57B08081173CC1F94D03944BAB17AFEA" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_C76F027FF45257FAC774944BAB17692B" xlink:to="loc_us-gaap_LongTermDebt_57B08081173CC1F94D03944BAB17AFEA" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtNotesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_C27C463B93954B2147B4B2B5E472E232" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:to="loc_us-gaap_DebtInstrumentTable_C27C463B93954B2147B4B2B5E472E232" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_262D9D3BD2BE3C8055EAB2B5E47288AF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_C27C463B93954B2147B4B2B5E472E232" xlink:to="loc_us-gaap_DebtInstrumentAxis_262D9D3BD2BE3C8055EAB2B5E47288AF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8956FDE51E74400B9BFAB2B5E47201F3_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_262D9D3BD2BE3C8055EAB2B5E47288AF" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8956FDE51E74400B9BFAB2B5E47201F3_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8956FDE51E74400B9BFAB2B5E47201F3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_262D9D3BD2BE3C8055EAB2B5E47288AF" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8956FDE51E74400B9BFAB2B5E47201F3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_B79734AB1951309FD8DCB2B5E472FD53" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8956FDE51E74400B9BFAB2B5E47201F3" xlink:to="loc_opk_NotesDueFebruary12033Member_B79734AB1951309FD8DCB2B5E472FD53" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_011666A14372F7A8003BB2B5E472815E" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_C27C463B93954B2147B4B2B5E472E232" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_011666A14372F7A8003BB2B5E472815E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_38F74326B6421D2EAC79B2B5E4728429_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_011666A14372F7A8003BB2B5E472815E" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_38F74326B6421D2EAC79B2B5E4728429_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_38F74326B6421D2EAC79B2B5E4728429" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_011666A14372F7A8003BB2B5E472815E" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_38F74326B6421D2EAC79B2B5E4728429" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_CE265C810533B9CB5D92B2B5E4724A3B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_38F74326B6421D2EAC79B2B5E4728429" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_CE265C810533B9CB5D92B2B5E4724A3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_2C7DB211414AD824DD26B2B5E4724676" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_2C7DB211414AD824DD26B2B5E4724676" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentsNumberofFinancialInstitutions" xlink:label="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_5466895A9ED362A0D078B2B5E473352C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:to="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_5466895A9ED362A0D078B2B5E473352C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_AEB9463C45D6948FF4BAB2B5E473DB64" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_AEB9463C45D6948FF4BAB2B5E473DB64" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentRollForward" xlink:label="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_53B68136DA3F8C296ED2B2B5E4725FFB" xlink:to="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_5BFA0153C5822C34F965B2B5E4731E2C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_5BFA0153C5822C34F965B2B5E4731E2C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_EB5A40510606FA7FD7B9B2B5E47353F3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_EB5A40510606FA7FD7B9B2B5E47353F3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_45B7DEB2C058F7F44D98B2B5E473815A" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_45B7DEB2C058F7F44D98B2B5E473815A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_73C09DD9CEA6D83321DEB2B5E473DB77" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_LongTermDebt_73C09DD9CEA6D83321DEB2B5E473DB77" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_EE21BC26D93C08C8C201B2B5E4739751" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_EE21BC26D93C08C8C201B2B5E4739751" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F4B4E9D8C388D44337C5B2B5E473CA2C" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F4B4E9D8C388D44337C5B2B5E473CA2C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EmbeddedDerivativeConversionGainLoss" xlink:label="loc_opk_EmbeddedDerivativeConversionGainLoss_CD962704F4FC871FAA42B2B5E4732DCE" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_opk_EmbeddedDerivativeConversionGainLoss_CD962704F4FC871FAA42B2B5E4732DCE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentConversionGainLoss" xlink:label="loc_opk_DebtInstrumentConversionGainLoss_6FEED546C5CD439C463AB2B5E473627E" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_opk_DebtInstrumentConversionGainLoss_6FEED546C5CD439C463AB2B5E473627E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConversionofAmortizationofDebtDiscountPremium" xlink:label="loc_opk_ConversionofAmortizationofDebtDiscountPremium_16D16E287B2A1E912B90B2B5E473C2D7" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_opk_ConversionofAmortizationofDebtDiscountPremium_16D16E287B2A1E912B90B2B5E473C2D7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EmbeddedDerivativeAndDebtInstrumentConversionGainLoss" xlink:label="loc_opk_EmbeddedDerivativeAndDebtInstrumentConversionGainLoss_3328A34655AE0AC52D3AB2B5E473504E" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DebtInstrumentRollForward_6D3B236F1E2CEEB945DBB2B5E473B745" xlink:to="loc_opk_EmbeddedDerivativeAndDebtInstrumentConversionGainLoss_3328A34655AE0AC52D3AB2B5E473504E" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_7F5581095B9EFBD9BAF49354584EB36E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:to="loc_us-gaap_DebtInstrumentTable_7F5581095B9EFBD9BAF49354584EB36E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_C41F6FF313B866DF34B79354584EBC57" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7F5581095B9EFBD9BAF49354584EB36E" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_C41F6FF313B866DF34B79354584EBC57" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_633C8C6F212341C261699354584E39DF_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_C41F6FF313B866DF34B79354584EBC57" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_633C8C6F212341C261699354584E39DF_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_633C8C6F212341C261699354584E39DF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_C41F6FF313B866DF34B79354584EBC57" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_633C8C6F212341C261699354584E39DF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_A15BD4941E1229F5A3999354584E9673" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_633C8C6F212341C261699354584E39DF" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_A15BD4941E1229F5A3999354584E9673" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_CFE5B83A37192ABB00B79354584E76F5" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7F5581095B9EFBD9BAF49354584EB36E" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_CFE5B83A37192ABB00B79354584E76F5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80D205DB23C05FEB71919354584E8F33_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CFE5B83A37192ABB00B79354584E76F5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80D205DB23C05FEB71919354584E8F33_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80D205DB23C05FEB71919354584E8F33" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CFE5B83A37192ABB00B79354584E76F5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80D205DB23C05FEB71919354584E8F33" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_4119652660445912A48D93713D0659F6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80D205DB23C05FEB71919354584E8F33" xlink:to="loc_opk_OPKOHealthEuropeMember_4119652660445912A48D93713D0659F6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_508A794F4F2A489C52F59354584E7C38" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_508A794F4F2A489C52F59354584E7C38" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_B75E6B515D905CDD5ED39354584E766B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_B75E6B515D905CDD5ED39354584E766B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" xlink:label="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_F3C3CFF6C44E6D04773A9354584E3F81" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:to="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_F3C3CFF6C44E6D04773A9354584E3F81" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock" xlink:label="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_6B9AB85A620BEEE4DD429354584EA14A" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_A2EAF06ECCF690544BF59354584EBAFD" xlink:to="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_6B9AB85A620BEEE4DD429354584EA14A" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DebtTextualDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_CE715556E0CD242AC16E944C77C3DB9A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_StatementClassOfStockAxis_CE715556E0CD242AC16E944C77C3DB9A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_18C50F9818FA1BB2C7C9944C77C3A134_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_CE715556E0CD242AC16E944C77C3DB9A" xlink:to="loc_us-gaap_ClassOfStockDomain_18C50F9818FA1BB2C7C9944C77C3A134_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_18C50F9818FA1BB2C7C9944C77C3A134" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_CE715556E0CD242AC16E944C77C3DB9A" xlink:to="loc_us-gaap_ClassOfStockDomain_18C50F9818FA1BB2C7C9944C77C3A134" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_34AC3BA20740E012BB6D944C77C41C4C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_18C50F9818FA1BB2C7C9944C77C3A134" xlink:to="loc_us-gaap_CommonStockMember_34AC3BA20740E012BB6D944C77C41C4C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_9F2C043F1336672F9867944C77C4C5CC" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_9F2C043F1336672F9867944C77C4C5CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9F2C043F1336672F9867944C77C4C5CC" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9F2C043F1336672F9867944C77C4C5CC" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_1169DAABC830777461FB944C77C4AE59" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_1169DAABC830777461FB944C77C4AE59" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_2DBBBBF20AE65AF2851C944C77C4AD53" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_ED7939025FE65A20B1D6944C77C40A77" xlink:to="loc_us-gaap_LineOfCreditMember_2DBBBBF20AE65AF2851C944C77C4AD53" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_03C6B7259AD7EAB6C60A944C77C44536" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_DebtInstrumentAxis_03C6B7259AD7EAB6C60A944C77C44536" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3E379CECFED441E675EC944C77C42AA0_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_03C6B7259AD7EAB6C60A944C77C44536" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3E379CECFED441E675EC944C77C42AA0_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3E379CECFED441E675EC944C77C42AA0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_03C6B7259AD7EAB6C60A944C77C44536" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3E379CECFED441E675EC944C77C42AA0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_F69A0F2EBE647328F083944C77C4065F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3E379CECFED441E675EC944C77C42AA0" xlink:to="loc_opk_NotesDueFebruary12033Member_F69A0F2EBE647328F083944C77C4065F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_3C6F355635E40CED7F71944C77C4FC2D" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_3C6F355635E40CED7F71944C77C4FC2D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B06F759CF4C03A6BE6E9944C77C47339_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_3C6F355635E40CED7F71944C77C4FC2D" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B06F759CF4C03A6BE6E9944C77C47339_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B06F759CF4C03A6BE6E9944C77C47339" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_3C6F355635E40CED7F71944C77C4FC2D" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B06F759CF4C03A6BE6E9944C77C47339" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_0252E82E1C7F8C37B569944C77C9EAF9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B06F759CF4C03A6BE6E9944C77C47339" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_0252E82E1C7F8C37B569944C77C9EAF9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_874E668E88DB3666CBA0944C77C92B08" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_RangeAxis_874E668E88DB3666CBA0944C77C92B08" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_874E668E88DB3666CBA0944C77C92B08" xlink:to="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_874E668E88DB3666CBA0944C77C92B08" xlink:to="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_C52F3066899589132321944C77C91CDA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0" xlink:to="loc_us-gaap_MinimumMember_C52F3066899589132321944C77C91CDA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_2C73F7B83F169FCB0C33944C77CA68B7" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_5265FF9A66CFCF69EF71944C77C9B0B0" xlink:to="loc_us-gaap_MaximumMember_2C73F7B83F169FCB0C33944C77CA68B7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_0BAB29B43657989530B7944C77CA7CC6" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_771C881D61196D9A02E3944C77C3D1DC" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_0BAB29B43657989530B7944C77CA7CC6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_083D151B209C887FC00E944C77CA9820_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0BAB29B43657989530B7944C77CA7CC6" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_083D151B209C887FC00E944C77CA9820_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_083D151B209C887FC00E944C77CA9820" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0BAB29B43657989530B7944C77CA7CC6" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_083D151B209C887FC00E944C77CA9820" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_7D4E65AB8430C315209E944C7812CB9C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_083D151B209C887FC00E944C77CA9820" xlink:to="loc_opk_OPKOHealthEuropeMember_7D4E65AB8430C315209E944C7812CB9C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_A1EFB6D15A1422EF48A8944C77CA8B0E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_A1EFB6D15A1422EF48A8944C77CA8B0E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4266988BBC3BAF880058944C77CAF328" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4266988BBC3BAF880058944C77CAF328" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_342BECD0F228019EE9CA944C77CAA0EF" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_342BECD0F228019EE9CA944C77CAA0EF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8DFB848B8704D9F4AD27944C77CA91E8" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8DFB848B8704D9F4AD27944C77CA91E8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentPrincipalAmountForConversion" xlink:label="loc_opk_DebtInstrumentPrincipalAmountForConversion_D2C31DBF1A5ADAA7CAAB944C77CA61DB" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_opk_DebtInstrumentPrincipalAmountForConversion_D2C31DBF1A5ADAA7CAAB944C77CA61DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_FBBFC2639DF2D4353145944C77CADE91" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_FBBFC2639DF2D4353145944C77CADE91" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_684CC70333431D02AF5D944C77CADA28" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_684CC70333431D02AF5D944C77CADA28" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentConvertibleThresholdForTradingDays" xlink:label="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_26BD009029D7C4718121944C77CA2CA4" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_26BD009029D7C4718121944C77CA2CA4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_A051EBCD9E13C8294FA9944C77CADC5A" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_A051EBCD9E13C8294FA9944C77CADC5A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentConvertibleConversionRightTriggered" xlink:label="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_383A6A42760A20B8A4D2944C77CBEAD4" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_383A6A42760A20B8A4D2944C77CBEAD4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_55707ACD744E5D3B9B7A945C038061B2" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_55707ACD744E5D3B9B7A945C038061B2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_47A11CCC6985598317A5944C77CA5CC0" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_47A11CCC6985598317A5944C77CA5CC0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnRepurchaseOfDebtInstrument" xlink:label="loc_us-gaap_GainLossOnRepurchaseOfDebtInstrument_6D84B89783280CD832D2944C77CA6CD3" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_GainLossOnRepurchaseOfDebtInstrument_6D84B89783280CD832D2944C77CA6CD3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="loc_us-gaap_DebtConversionOriginalDebtAmount1_3BD26380541B05E43709944C77CA7461" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtConversionOriginalDebtAmount1_3BD26380541B05E43709944C77CA7461" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_1C272AFB5560413EC819944C77CB461C" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_InterestPaid_1C272AFB5560413EC819944C77CB461C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_C51B3460BCD7E81AE047944C77CBA480" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_C51B3460BCD7E81AE047944C77CBA480" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_97E2172219446BA6A270944C77CAA572" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_LongTermDebt_97E2172219446BA6A270944C77CAA572" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_973A966B415C050AF3D2944C77CB220F" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_973A966B415C050AF3D2944C77CB220F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtInstrumentsNumberofFinancialInstitutions" xlink:label="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_26C6FF306E6C32C0A40C944C77CB6DDC" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_26C6FF306E6C32C0A40C944C77CB6DDC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_9C7DFB02C40FBE58972F944C77CB7373" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_9C7DFB02C40FBE58972F944C77CB7373" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_E96003DB5EBD55E93DCC944C77CBE66D" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7B2ED289A36C84706E98944C77CA75D1" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_E96003DB5EBD55E93DCC944C77CBE66D" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DerivativeContracts" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/DerivativeContractsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_6C4F99AE543B9AB772DBB2B5E3C846C1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_67AB6F30CBDE8DCC2DF3B2B5E3C78E62" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6C4F99AE543B9AB772DBB2B5E3C846C1" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_67AB6F30CBDE8DCC2DF3B2B5E3C78E62" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_9A9E4A478EFFDCEA2112B2B5E3C73E95" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_67AB6F30CBDE8DCC2DF3B2B5E3C78E62" xlink:to="loc_us-gaap_HedgingDesignationAxis_9A9E4A478EFFDCEA2112B2B5E3C73E95" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_456DCC696BAD997E31F5B2B5E3C78EDF_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_9A9E4A478EFFDCEA2112B2B5E3C73E95" xlink:to="loc_us-gaap_HedgingDesignationDomain_456DCC696BAD997E31F5B2B5E3C78EDF_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_456DCC696BAD997E31F5B2B5E3C78EDF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_9A9E4A478EFFDCEA2112B2B5E3C73E95" xlink:to="loc_us-gaap_HedgingDesignationDomain_456DCC696BAD997E31F5B2B5E3C78EDF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_5CA809235CC58296D935B2B5E3C70471" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_456DCC696BAD997E31F5B2B5E3C78EDF" xlink:to="loc_us-gaap_NondesignatedMember_5CA809235CC58296D935B2B5E3C70471" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_EE1FFD7755E248F02AA4B2B5E3C76135" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_67AB6F30CBDE8DCC2DF3B2B5E3C78E62" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_EE1FFD7755E248F02AA4B2B5E3C76135" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_EE1FFD7755E248F02AA4B2B5E3C76135" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_EE1FFD7755E248F02AA4B2B5E3C76135" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NoteReceivableandPurchaseOptionMember" xlink:label="loc_opk_NoteReceivableandPurchaseOptionMember_DA053C7C806326678DFFB2B5E3C7410F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:to="loc_opk_NoteReceivableandPurchaseOptionMember_DA053C7C806326678DFFB2B5E3C7410F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_us-gaap_StockOptionMember_783E18A56BE885A0E27AB2B5E3C7EBF7" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:to="loc_us-gaap_StockOptionMember_783E18A56BE885A0E27AB2B5E3C7EBF7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_B3CD66DF67E28C8A3358B2B5E3C89E2B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:to="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_B3CD66DF67E28C8A3358B2B5E3C89E2B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_40B7745E1BD2CBFA5DAAB2B5E3C8E5C2" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3F611DF12EB3B0474FE5B2B5E3C7020A" xlink:to="loc_us-gaap_ForwardContractsMember_40B7745E1BD2CBFA5DAAB2B5E3C8E5C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_2CB238B09E2A38520AB6B2B5E3C89CF8" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_67AB6F30CBDE8DCC2DF3B2B5E3C78E62" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_2CB238B09E2A38520AB6B2B5E3C89CF8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2CB238B09E2A38520AB6B2B5E3C89CF8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2CB238B09E2A38520AB6B2B5E3C89CF8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_88CC2C4770957406D3E3B2B5E3C87A56" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_88CC2C4770957406D3E3B2B5E3C87A56" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InvestmentsMember" xlink:label="loc_us-gaap_InvestmentsMember_80E6CBC4F0E701CDD17AB2B5E3C8FBA5" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:to="loc_us-gaap_InvestmentsMember_80E6CBC4F0E701CDD17AB2B5E3C8FBA5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" xlink:label="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_073F38221EC4F63230E7B2B5E3C8B0D7" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:to="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_073F38221EC4F63230E7B2B5E3C8B0D7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LongtermDebtCurrentMaturitiesMember" xlink:label="loc_opk_LongtermDebtCurrentMaturitiesMember_925966D44408F28CEA0FB2B5E3C8FFB4" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_00CD726BE13F1941A098B2B5E3C8DD47" xlink:to="loc_opk_LongtermDebtCurrentMaturitiesMember_925966D44408F28CEA0FB2B5E3C8FFB4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_28E109C4DAB105615018B2B5E3C82EB1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6C4F99AE543B9AB772DBB2B5E3C846C1" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_28E109C4DAB105615018B2B5E3C82EB1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_A604D5699BFBC34AB289B2B5E3C862A1" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6C4F99AE543B9AB772DBB2B5E3C846C1" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_A604D5699BFBC34AB289B2B5E3C862A1" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DerivativeContractsDetails1" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7E5308B5B0460E92C39CB2B5E3C35E3E" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_0813AF5B527CDC0429FBB2B5E3C37A62" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7E5308B5B0460E92C39CB2B5E3C35E3E" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_0813AF5B527CDC0429FBB2B5E3C37A62" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_98978B64AC170D5DF2C3B2B5E3C37906" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_0813AF5B527CDC0429FBB2B5E3C37A62" xlink:to="loc_us-gaap_HedgingDesignationAxis_98978B64AC170D5DF2C3B2B5E3C37906" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_0758D433589E40BCBA7AB2B5E3C30FED_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_98978B64AC170D5DF2C3B2B5E3C37906" xlink:to="loc_us-gaap_HedgingDesignationDomain_0758D433589E40BCBA7AB2B5E3C30FED_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_0758D433589E40BCBA7AB2B5E3C30FED" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_98978B64AC170D5DF2C3B2B5E3C37906" xlink:to="loc_us-gaap_HedgingDesignationDomain_0758D433589E40BCBA7AB2B5E3C30FED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_5745E56A5A4DC25FF537B2B5E3C31B29" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_0758D433589E40BCBA7AB2B5E3C30FED" xlink:to="loc_us-gaap_NondesignatedMember_5745E56A5A4DC25FF537B2B5E3C31B29" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ABCC374E0CF0D8B46ABEB2B5E3C39B87" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_0813AF5B527CDC0429FBB2B5E3C37A62" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ABCC374E0CF0D8B46ABEB2B5E3C39B87" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ABCC374E0CF0D8B46ABEB2B5E3C39B87" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ABCC374E0CF0D8B46ABEB2B5E3C39B87" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_us-gaap_StockOptionMember_F70B6BA06083AA585695B2B5E3C3C164" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E" xlink:to="loc_us-gaap_StockOptionMember_F70B6BA06083AA585695B2B5E3C3C164" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_12D0975AAFCE4EA76700B2B5E3C30F07" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_12D0975AAFCE4EA76700B2B5E3C30F07" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_8452397BA40B59AC2AB6B2B5E3C3CC06" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_995A94CFCC0FDB0C27E3B2B5E3C3C90E" xlink:to="loc_us-gaap_ForwardContractsMember_8452397BA40B59AC2AB6B2B5E3C3CC06" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_11B2D4DF6F8F82DF0B35B2B5E3C3EE3C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7E5308B5B0460E92C39CB2B5E3C35E3E" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_11B2D4DF6F8F82DF0B35B2B5E3C3EE3C" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DerivativeContractsDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_B1DEA0AFF7628D0BF40AC92C8F149945" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeTable_B1DEA0AFF7628D0BF40AC92C8F149945" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_6D7C6C45C28005B1FBB4C92C8F15738C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_B1DEA0AFF7628D0BF40AC92C8F149945" xlink:to="loc_us-gaap_HedgingDesignationAxis_6D7C6C45C28005B1FBB4C92C8F15738C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_964CE68ABA15404DCFEEC92C8F1636F2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_6D7C6C45C28005B1FBB4C92C8F15738C" xlink:to="loc_us-gaap_HedgingDesignationDomain_964CE68ABA15404DCFEEC92C8F1636F2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_964CE68ABA15404DCFEEC92C8F1636F2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_6D7C6C45C28005B1FBB4C92C8F15738C" xlink:to="loc_us-gaap_HedgingDesignationDomain_964CE68ABA15404DCFEEC92C8F1636F2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_A6BEEE68C48B7DA8C888C92C8F1619F7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_964CE68ABA15404DCFEEC92C8F1636F2" xlink:to="loc_us-gaap_NondesignatedMember_A6BEEE68C48B7DA8C888C92C8F1619F7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_68584C575018B1DAB8D0C92C8F1713BC" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_B1DEA0AFF7628D0BF40AC92C8F149945" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_68584C575018B1DAB8D0C92C8F1713BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_21526D719D4D5542D7CAC92C8F178F7D_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_68584C575018B1DAB8D0C92C8F1713BC" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_21526D719D4D5542D7CAC92C8F178F7D_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_21526D719D4D5542D7CAC92C8F178F7D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_68584C575018B1DAB8D0C92C8F1713BC" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_21526D719D4D5542D7CAC92C8F178F7D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_B7B03084C4E9372F6CD4C92C8F178C9B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_21526D719D4D5542D7CAC92C8F178F7D" xlink:to="loc_us-gaap_ForwardContractsMember_B7B03084C4E9372F6CD4C92C8F178C9B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeByMaturityAxis" xlink:label="loc_opk_DerivativeByMaturityAxis_25ED551B8295CD60411CC92C8F17CBE6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_B1DEA0AFF7628D0BF40AC92C8F149945" xlink:to="loc_opk_DerivativeByMaturityAxis_25ED551B8295CD60411CC92C8F17CBE6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeByMaturityDomain" xlink:label="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_opk_DerivativeByMaturityAxis_25ED551B8295CD60411CC92C8F17CBE6" xlink:to="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9_default" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeByMaturityDomain" xlink:label="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_opk_DerivativeByMaturityAxis_25ED551B8295CD60411CC92C8F17CBE6" xlink:to="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturityZerotoThirtyDaysMember" xlink:label="loc_opk_DerivativeMaturityZerotoThirtyDaysMember_D68ED4C6D62A5977748AC92C8F17296B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturityZerotoThirtyDaysMember_D68ED4C6D62A5977748AC92C8F17296B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturityThirtyOnetoSixtyDaysMember" xlink:label="loc_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_011F05CF9E09CDD0E1EAC92C8F18473A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_011F05CF9E09CDD0E1EAC92C8F18473A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturitySixtyOnetoNinetyDaysMember" xlink:label="loc_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_6FCF846BFDA95714BD6CC92C8F189B5F" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_6FCF846BFDA95714BD6CC92C8F189B5F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember" xlink:label="loc_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_C98D103150A22930BC34C92C8F18A622" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_C98D103150A22930BC34C92C8F18A622" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember" xlink:label="loc_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_6184874967742D0F8AB6C92C8F18E4BA" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_6184874967742D0F8AB6C92C8F18E4BA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DerivativeMaturityMorethanOneHundredEightyDaysMember" xlink:label="loc_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_27DDF616A3FF0D2775C1C92C8F184563" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_DerivativeByMaturityDomain_A2E4869085822B518F34C92C8F179BF9" xlink:to="loc_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_27DDF616A3FF0D2775C1C92C8F184563" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_1E00C4A441317B109DF3C92C8F18791C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_1E00C4A441317B109DF3C92C8F18791C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_555017B4DDB8C3FCC806C92C8F1B0C86" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_555017B4DDB8C3FCC806C92C8F1B0C86" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_B34D4D71C9A48EED38F8C9389F01A7DA" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_B34D4D71C9A48EED38F8C9389F01A7DA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_UnrealizedGainLossOnDerivatives" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_56419C909C2A833475F0C93801D71715" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_56419C909C2A833475F0C93801D71715" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeLowerRemainingMaturityRange1" xlink:label="loc_us-gaap_DerivativeLowerRemainingMaturityRange1_AFF8C35D55DBD1B69549C92C8F1BC3E4" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeLowerRemainingMaturityRange1_AFF8C35D55DBD1B69549C92C8F1BC3E4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DerivativeHigherRemainingMaturityRange1" xlink:label="loc_us-gaap_DerivativeHigherRemainingMaturityRange1_7A179F1C27A8003429ABC92C8F1B9DFD" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_116B0F08CEACBBF159F0C92C8F18103F" xlink:to="loc_us-gaap_DerivativeHigherRemainingMaturityRange1_7A179F1C27A8003429ABC92C8F1B9DFD" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/DerivativeContractsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/DocumentAndEntityInformation" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/EmployeeBenefitPlans" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/EmployeeBenefitPlansDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/EquityBasedCompensation" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/EquityBasedCompensationDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A6F554E9749C4E5DDBDD947EBCC27E1D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1DAD957AB5FF15224128947EBCC2DDCB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A6F554E9749C4E5DDBDD947EBCC27E1D" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1DAD957AB5FF15224128947EBCC2DDCB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_0A0B64D32632B2201885947EBCC2541C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1DAD957AB5FF15224128947EBCC2DDCB" xlink:to="loc_us-gaap_RangeAxis_0A0B64D32632B2201885947EBCC2541C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_0A0B64D32632B2201885947EBCC2541C" xlink:to="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_0A0B64D32632B2201885947EBCC2541C" xlink:to="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_94746A9DD264F8EF6221947EBCC25B22" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A" xlink:to="loc_us-gaap_MinimumMember_94746A9DD264F8EF6221947EBCC25B22" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_ED60B1E0245CD58EAABA947EBCC2E59B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_E791F74DA419F98790DF947EBCC29E8A" xlink:to="loc_us-gaap_MaximumMember_ED60B1E0245CD58EAABA947EBCC2E59B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A6F554E9749C4E5DDBDD947EBCC27E1D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_BA3D4AC49D4F481E599B947EBCC3A374" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_BA3D4AC49D4F481E599B947EBCC3A374" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_D26325404878874A40DE947EBCC33D8C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_D26325404878874A40DE947EBCC33D8C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_B13168CA8004F428CC91947EBCC3E091" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_B13168CA8004F428CC91947EBCC3E091" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_E6D699D625C35EBF0C4A947EBCC32B27" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_E6D699D625C35EBF0C4A947EBCC32B27" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_E88FED92E6262F04E6EF947EBCC36409" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_E88FED92E6262F04E6EF947EBCC36409" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_101679AFFBD925C181EC947EBCC3E447" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_101679AFFBD925C181EC947EBCC3E447" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_34B46249FA274E344B61947EBCC3B51A" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_295F366F000DBB745958947EBCC314A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_34B46249FA274E344B61947EBCC3B51A" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/EquityBasedCompensationDetails1" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/EquityBasedCompensationDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_F884F11F108DD76AB942CBC58767AA9D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:to="loc_us-gaap_RangeAxis_F884F11F108DD76AB942CBC58767AA9D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_F884F11F108DD76AB942CBC58767AA9D" xlink:to="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_F884F11F108DD76AB942CBC58767AA9D" xlink:to="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_1B3B778AE83D51784DBBCBC587671D1A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B" xlink:to="loc_us-gaap_MinimumMember_1B3B778AE83D51784DBBCBC587671D1A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A3485939AF54CD01413CCBC58767DE79" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_BD10645F5D1DA8537E7CCBC58767780B" xlink:to="loc_us-gaap_MaximumMember_A3485939AF54CD01413CCBC58767DE79" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_508E35AE7210BB40BA3ACBC58768596D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_508E35AE7210BB40BA3ACBC58768596D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_0A21791471E5632FCE8DCBC5876881F9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_508E35AE7210BB40BA3ACBC58768596D" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_0A21791471E5632FCE8DCBC5876881F9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_0A21791471E5632FCE8DCBC5876881F9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_508E35AE7210BB40BA3ACBC58768596D" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_0A21791471E5632FCE8DCBC5876881F9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentContinuingOperationsMember" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_DF2450E724968BA90F92CBC587682059" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_0A21791471E5632FCE8DCBC5876881F9" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_DF2450E724968BA90F92CBC587682059" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_8F970C1ED3EDB36AF802CBC58768EE36" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:to="loc_us-gaap_PlanNameAxis_8F970C1ED3EDB36AF802CBC58768EE36" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_19AFAB667650D28314F7CBC5876814CF_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_8F970C1ED3EDB36AF802CBC58768EE36" xlink:to="loc_us-gaap_PlanNameDomain_19AFAB667650D28314F7CBC5876814CF_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_19AFAB667650D28314F7CBC5876814CF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_8F970C1ED3EDB36AF802CBC58768EE36" xlink:to="loc_us-gaap_PlanNameDomain_19AFAB667650D28314F7CBC5876814CF" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TwoThousandSevenEquityIncentivePlanMember" xlink:label="loc_opk_TwoThousandSevenEquityIncentivePlanMember_E531A83DAA2DF7B6A5AFCBC58768CC1C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_19AFAB667650D28314F7CBC5876814CF" xlink:to="loc_opk_TwoThousandSevenEquityIncentivePlanMember_E531A83DAA2DF7B6A5AFCBC58768CC1C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_FDA0ADF9B386487DA420CBC5876E46EF" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_EB138DD46D3EB3568892CBC58767D6C9" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_FDA0ADF9B386487DA420CBC5876E46EF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_FDA0ADF9B386487DA420CBC5876E46EF" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_FDA0ADF9B386487DA420CBC5876E46EF" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_6427378A8FBF5D463476CBC5876E550E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_6427378A8FBF5D463476CBC5876E550E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_072978A553740EEAAA6DCBC5876ED600" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_072978A553740EEAAA6DCBC5876ED600" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CostOfSalesMember" xlink:label="loc_us-gaap_CostOfSalesMember_0E61CD88773097A88A73CBC5876EE4E1" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_47E0890F206457C33706CBC5876E1F9A" xlink:to="loc_us-gaap_CostOfSalesMember_0E61CD88773097A88A73CBC5876EE4E1" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NumberOfEquityBasedIncentiveCompensationPlans" xlink:label="loc_opk_NumberOfEquityBasedIncentiveCompensationPlans_9932D3A9A3E655399710CBC5876FA9ED" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_opk_NumberOfEquityBasedIncentiveCompensationPlans_9932D3A9A3E655399710CBC5876FA9ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_A6A9F0FE5BF7DC7F3F8BCBC5876FF405" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_A6A9F0FE5BF7DC7F3F8BCBC5876FF405" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_53116CD41077DB43E703CBC5876F8D72" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_53116CD41077DB43E703CBC5876F8D72" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationExcessTaxBenefits" xlink:label="loc_opk_ShareBasedCompensationExcessTaxBenefits_B34BDC780CB8B81DA2E0CBC5876F6040" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_opk_ShareBasedCompensationExcessTaxBenefits_B34BDC780CB8B81DA2E0CBC5876F6040" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_E748FC47D59E1941AD9ECBC5876FBA9C" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_E748FC47D59E1941AD9ECBC5876FBA9C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_88D8A5F6C225AE04D4BECBC5876FF40A" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_88D8A5F6C225AE04D4BECBC5876FF40A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_01EF17BFAE17C5A649A3CBC5876F0C6A" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_01EF17BFAE17C5A649A3CBC5876F0C6A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingDescription" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingDescription_BBB4FBA44CA7576C7159CBC5876F939A" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingDescription_BBB4FBA44CA7576C7159CBC5876F939A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingOfSelectedPublicStockDescription" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingOfSelectedPublicStockDescription_E7F714E6481757428363CBC5876FA5FB" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOnHistoricalTradingOfSelectedPublicStockDescription_E7F714E6481757428363CBC5876FA5FB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_30B7EB81B98DFF756CCBCBC5876F7212" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_30B7EB81B98DFF756CCBCBC5876F7212" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_40009F6A66DE87511DF5CBC58770804E" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_40009F6A66DE87511DF5CBC58770804E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_EED45AA384563154FF72CBC58770E4C8" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_EED45AA384563154FF72CBC58770E4C8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1_CDD2E976EECB7B0A0E86CBC5877074E0" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1_CDD2E976EECB7B0A0E86CBC5877074E0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RestrictedStockSharesIssuedDuringPeriod" xlink:label="loc_opk_RestrictedStockSharesIssuedDuringPeriod_AA029367565EF4E09DE1CBC58770DB40" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_36A315F27A8926C41B67CBC5876E9860" xlink:to="loc_opk_RestrictedStockSharesIssuedDuringPeriod_AA029367565EF4E09DE1CBC58770DB40" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/EquityBasedCompensationTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurements" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsAssetsAndLiabilitiesMeasuredAtFairValueDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_0B04E58BD3ABDFE086F8B394E99392DD" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_0B04E58BD3ABDFE086F8B394E99392DD" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0A04D230FF5DD08B3A54B394E9915034" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0A04D230FF5DD08B3A54B394E9915034" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_226A1146FE5074B164BAB394E991C611_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0A04D230FF5DD08B3A54B394E9915034" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_226A1146FE5074B164BAB394E991C611_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_226A1146FE5074B164BAB394E991C611" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0A04D230FF5DD08B3A54B394E9915034" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_226A1146FE5074B164BAB394E991C611" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_1775838C346EE8A384BDB394E9915A58" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_226A1146FE5074B164BAB394E991C611" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_1775838C346EE8A384BDB394E9915A58" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_4CA7A8405E4EDB8B679AB394E99197DE" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_4CA7A8405E4EDB8B679AB394E99197DE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_4CA7A8405E4EDB8B679AB394E99197DE" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_4CA7A8405E4EDB8B679AB394E99197DE" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_1E594F255BC43D673754B394E991994D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_MoneyMarketFundsMember_1E594F255BC43D673754B394E991994D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CertificatesOfDepositMember" xlink:label="loc_us-gaap_CertificatesOfDepositMember_D9DF856157DD5F1C701EB394E99154AC" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_CertificatesOfDepositMember_D9DF856157DD5F1C701EB394E99154AC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NotesReceivableMember" xlink:label="loc_us-gaap_NotesReceivableMember_70A9CE3A1D447BD249F2B394E9922ADD" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_NotesReceivableMember_70A9CE3A1D447BD249F2B394E9922ADD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_67FF201BB120A4B08A51B394E9924173" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_CommonStockMember_67FF201BB120A4B08A51B394E9924173" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_766B7192211C98301BC5B394E99273C9" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_766B7192211C98301BC5B394E99273C9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_C40EAFD809B8A805F21BB394E9922F02" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0C44A7BF81EDE4C74857B394E9917401" xlink:to="loc_us-gaap_ForwardContractsMember_C40EAFD809B8A805F21BB394E9922F02" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_5F9C761E3F330C37C45BB394E992B772" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_5F9C761E3F330C37C45BB394E992B772" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_5F9C761E3F330C37C45BB394E992B772" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_5F9C761E3F330C37C45BB394E992B772" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_20B3405B905BC9D06E47B394E992C28B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:to="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_20B3405B905BC9D06E47B394E992C28B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_785A3730969C442A8F09B39783C4F382" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:to="loc_us-gaap_ForwardContractsMember_785A3730969C442A8F09B39783C4F382" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscountMember" xlink:label="loc_opk_DeferredAcquisitionPaymentsNetOfDiscountMember_19FCC19EEF4CF1485767B394E99270D4" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:to="loc_opk_DeferredAcquisitionPaymentsNetOfDiscountMember_19FCC19EEF4CF1485767B394E99270D4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ContingentConsiderationMember" xlink:label="loc_opk_ContingentConsiderationMember_F3F9F6157D071F5110ABB394E992447B" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_18D2B1BF32B757235A49B394E992EA84" xlink:to="loc_opk_ContingentConsiderationMember_F3F9F6157D071F5110ABB394E992447B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_BC47F5C413A708AA611BB394E9924F96" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_BC47F5C413A708AA611BB394E9924F96" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BC47F5C413A708AA611BB394E9924F96" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BC47F5C413A708AA611BB394E9924F96" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_DD2571F3CC0ABA4938E5B394E9924C8F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:to="loc_opk_CURNAMember_DD2571F3CC0ABA4938E5B394E9924C8F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_D76AD6BB2A84EAFBB52CB394E992E9CB" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:to="loc_opk_OpkoDiagnosticsMember_D76AD6BB2A84EAFBB52CB394E992E9CB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_119531B3BEB04C55B27CB394E9925075" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:to="loc_opk_FineTechMember_119531B3BEB04C55B27CB394E9925075" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_8AEB3CD1570DC7AD668EB394E9922096" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:to="loc_opk_OPKORenalMember_8AEB3CD1570DC7AD668EB394E9922096" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_A84F83DD637792BE3ED3B394E9922BBB" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7ABFBE4E70401E0696AB394E992FA98" xlink:to="loc_opk_OPKOHealthEuropeMember_A84F83DD637792BE3ED3B394E9922BBB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BB74CBDF880C920A608EB394E992C260" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_017B56DC5FA8101EFF6DB394E9910A22" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BB74CBDF880C920A608EB394E992C260" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BB74CBDF880C920A608EB394E992C260" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_BB74CBDF880C920A608EB394E992C260" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_825CC02C182D580F2197B394E9927DEA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_825CC02C182D580F2197B394E9927DEA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_41B1CBB9F0D330FB7BDEB394E9928196" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_41B1CBB9F0D330FB7BDEB394E9928196" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_A76B68D61FE195EE965DB394E9920572" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_766C4295D7238E86D859B394E9929F36" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_A76B68D61FE195EE965DB394E9920572" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_4CED619D39F7A027A947B394E9936C1E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_0B04E58BD3ABDFE086F8B394E99392DD" xlink:to="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_4CED619D39F7A027A947B394E9936C1E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_8D7F7CF523CD559045B8B394E99352B4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_4CED619D39F7A027A947B394E9936C1E" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_8D7F7CF523CD559045B8B394E99352B4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_03302678846C1BF86C82B394E9930A80" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_0B04E58BD3ABDFE086F8B394E99392DD" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_03302678846C1BF86C82B394E9930A80" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_C3CD27C54631F19EB546B394E99364A5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_03302678846C1BF86C82B394E9930A80" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_C3CD27C54631F19EB546B394E99364A5" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsLevel3ReconciliationDetails" xlink:type="extended">
<loc xlink:href="opk-20141231.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_58AB1575A459028AF112C8D6698A0066" xlink:type="locator"/>
<loc xlink:href="opk-20141231.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_16A252EEF8BED67279E5C8D669888243" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_58AB1575A459028AF112C8D6698A0066" xlink:to="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_16A252EEF8BED67279E5C8D669888243" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_64865EF2545957689EE9C8D66989E99C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_16A252EEF8BED67279E5C8D669888243" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_64865EF2545957689EE9C8D66989E99C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_AEA447D6739A48D2D9C1C8D669895DB5_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_64865EF2545957689EE9C8D66989E99C" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_AEA447D6739A48D2D9C1C8D669895DB5_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_AEA447D6739A48D2D9C1C8D669895DB5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_64865EF2545957689EE9C8D66989E99C" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_AEA447D6739A48D2D9C1C8D669895DB5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_8FBB321E71A0018D3A5CC8D669890904" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_AEA447D6739A48D2D9C1C8D669895DB5" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_8FBB321E71A0018D3A5CC8D669890904" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_F06BD6CCDFD904FC5F3FC8D6698911E6" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_16A252EEF8BED67279E5C8D669888243" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_F06BD6CCDFD904FC5F3FC8D6698911E6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_F06BD6CCDFD904FC5F3FC8D6698911E6" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_F06BD6CCDFD904FC5F3FC8D6698911E6" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ContingentConsiderationMember" xlink:label="loc_opk_ContingentConsiderationMember_21330364A8D8ACAB6ADFC8D669899213" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73" xlink:to="loc_opk_ContingentConsiderationMember_21330364A8D8ACAB6ADFC8D669899213" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscountMember" xlink:label="loc_opk_DeferredAcquisitionPaymentsNetOfDiscountMember_7E81FEB52B1ABA0B21D8C8D6698906E2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73" xlink:to="loc_opk_DeferredAcquisitionPaymentsNetOfDiscountMember_7E81FEB52B1ABA0B21D8C8D6698906E2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_34AA8A8FA90DD9EBF633C8D669898588" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_04740B03BCA6B8A791B5C8D669890B73" xlink:to="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_34AA8A8FA90DD9EBF633C8D669898588" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_37263DF31657F76C766BC8D6698A50D7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_58AB1575A459028AF112C8D6698A0066" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_37263DF31657F76C766BC8D6698A50D7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisAssetGainLossAbstract" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisAssetGainLossAbstract_D26BD581CC0CED7C3D0CC8D6698A157E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_37263DF31657F76C766BC8D6698A50D7" xlink:to="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisAssetGainLossAbstract_D26BD581CC0CED7C3D0CC8D6698A157E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_8D1DA600BB2F8306B82AC8D6698A0FF9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisAssetGainLossAbstract_D26BD581CC0CED7C3D0CC8D6698A157E" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_8D1DA600BB2F8306B82AC8D6698A0FF9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_0A505181FAA8DD42A76EC8D6698A05B0" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisAssetGainLossAbstract_D26BD581CC0CED7C3D0CC8D6698A157E" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_0A505181FAA8DD42A76EC8D6698A05B0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_539805242CF1672E2A36C8D6698AACA3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_58AB1575A459028AF112C8D6698A0066" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_539805242CF1672E2A36C8D6698AACA3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_539805242CF1672E2A36C8D6698AACA3" xlink:to="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_8F8E38A15C8958BB102AC8D6698F3578" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_8F8E38A15C8958BB102AC8D6698F3578" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_D813AFDE4C17DDB76FACC8D6698F6A3A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_D813AFDE4C17DDB76FACC8D6698F6A3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_128FB5181F48E56A71C3C8D6698F35AC" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_128FB5181F48E56A71C3C8D6698F35AC" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_7B8B82D9F05F809D7AC2C8D6698F3FFB" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_7B8B82D9F05F809D7AC2C8D6698F3FFB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_57E602374F2F4D6B0A1AC8D6699098DD" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_57E602374F2F4D6B0A1AC8D6699098DD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DebtConversionEmbeddedDerivativeAmount" xlink:label="loc_opk_DebtConversionEmbeddedDerivativeAmount_644A628DB5CFAF4C3AAFC8D66990F56B" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_9416025E85ED07F020E1C8D6698F2C66" xlink:to="loc_opk_DebtConversionEmbeddedDerivativeAmount_644A628DB5CFAF4C3AAFC8D66990F56B" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsNotesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_15467282E1E53A84916BB394E98BEDB3" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_9F17FD3843962C079C8CB394E98AACDA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_15467282E1E53A84916BB394E98BEDB3" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_9F17FD3843962C079C8CB394E98AACDA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1ED8687D8E0C7DC6F261B394E98A04E6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_9F17FD3843962C079C8CB394E98AACDA" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1ED8687D8E0C7DC6F261B394E98A04E6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_6411B18861DFACAF68A5B394E98AD7B6_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1ED8687D8E0C7DC6F261B394E98A04E6" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_6411B18861DFACAF68A5B394E98AD7B6_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_6411B18861DFACAF68A5B394E98AD7B6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1ED8687D8E0C7DC6F261B394E98A04E6" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_6411B18861DFACAF68A5B394E98AD7B6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_400D12B696DEA91167EDB394E98A10CB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_6411B18861DFACAF68A5B394E98AD7B6" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_400D12B696DEA91167EDB394E98A10CB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_8100E37E17C538E6B700B394E98A5D3D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_9F17FD3843962C079C8CB394E98AACDA" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_8100E37E17C538E6B700B394E98A5D3D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_BB1041C87B7583C2AB76B394E98B6838_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_8100E37E17C538E6B700B394E98A5D3D" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_BB1041C87B7583C2AB76B394E98B6838_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DD5F5F9CDA5BC534CDF8B394E98B208D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_8100E37E17C538E6B700B394E98A5D3D" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DD5F5F9CDA5BC534CDF8B394E98B208D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_BB1041C87B7583C2AB76B394E98B6838" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DD5F5F9CDA5BC534CDF8B394E98B208D" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_BB1041C87B7583C2AB76B394E98B6838" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_641A043208FB50520AA8B394E98B0737" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DD5F5F9CDA5BC534CDF8B394E98B208D" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_641A043208FB50520AA8B394E98B0737" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_70A3775FD65FA34ED836B394E98B4D1F" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_9F17FD3843962C079C8CB394E98AACDA" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_70A3775FD65FA34ED836B394E98B4D1F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_70A3775FD65FA34ED836B394E98B4D1F" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_70A3775FD65FA34ED836B394E98B4D1F" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_8D9C23B8E8FD29BE5989B394E98B0A1A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_8D9C23B8E8FD29BE5989B394E98B0A1A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_DC6EA0D8E33E61D8CBB0B394E98BDA31" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_DC6EA0D8E33E61D8CBB0B394E98BDA31" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_2099FEBEDA5084CD8893B394E98B3F22" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38FC546AB9ABA2F8EFDEB394E98B6B85" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_2099FEBEDA5084CD8893B394E98B3F22" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NotesPayableFairValueDisclosure" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_D3D817CFBA502EA3DAB7B394E98BBF3B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_15467282E1E53A84916BB394E98BEDB3" xlink:to="loc_us-gaap_NotesPayableFairValueDisclosure_D3D817CFBA502EA3DAB7B394E98BBF3B" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsSummaryOfInvestmentsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_2AD843656C9407A28B6CB394EB6BBE21" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_2AD843656C9407A28B6CB394EB6BBE21" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_832EF75724B6D84FB582B394EB6B97CF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_2AD843656C9407A28B6CB394EB6BBE21" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_832EF75724B6D84FB582B394EB6B97CF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_832EF75724B6D84FB582B394EB6B97CF" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_832EF75724B6D84FB582B394EB6B97CF" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_A60ABD45E7F36D83541CB394EB6BA552" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999" xlink:to="loc_us-gaap_CommonStockMember_A60ABD45E7F36D83541CB394EB6BA552" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_DFF0E8AFD1B2F13D9E40B394EB6C51BB" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3B04BAD0E3C8985BC1B7B394EB6BB999" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_DFF0E8AFD1B2F13D9E40B394EB6C51BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_A382ECE3700E08A271BBB394EB6C60D5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_A382ECE3700E08A271BBB394EB6C60D5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments" xlink:label="loc_opk_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_B2BCD44650F4D6C727E3B394EB6C0BB7" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_opk_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_B2BCD44650F4D6C727E3B394EB6C0BB7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments" xlink:label="loc_opk_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_A009E7A6A3E9373E8DC4B394EB6CDCB6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_opk_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_A009E7A6A3E9373E8DC4B394EB6CDCB6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet" xlink:label="loc_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_6911294CEE1A60AEF8B9B394EB6C463C" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_6911294CEE1A60AEF8B9B394EB6C463C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_0937C3028CF80BDEA61DB394EB6C0711" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_FAB6748DF8457CC08640B394EB6C402F" xlink:to="loc_us-gaap_AvailableForSaleSecurities_0937C3028CF80BDEA61DB394EB6C0711" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/FairValueMeasurementsTextualDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_96162EF02730254BF9FAB394E9788B03" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_96162EF02730254BF9FAB394E9788B03" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_C955401F41E7CC19BC6EB394E9785CA2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_96162EF02730254BF9FAB394E9788B03" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_C955401F41E7CC19BC6EB394E9785CA2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_C955401F41E7CC19BC6EB394E9785CA2" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_C955401F41E7CC19BC6EB394E9785CA2" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_DF2A1905C35612AB0443B394E978C94A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_DF2A1905C35612AB0443B394E978C94A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_F181C24B5F090448D98DB394E9785D12" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_215E86E806BA8FA68FB8B394E9783D22" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_F181C24B5F090448D98DB394E9785D12" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_D3E6BE130CAE4A6872A5B394E9782E2E" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_96162EF02730254BF9FAB394E9788B03" xlink:to="loc_us-gaap_RangeAxis_D3E6BE130CAE4A6872A5B394E9782E2E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_D3E6BE130CAE4A6872A5B394E9782E2E" xlink:to="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_D3E6BE130CAE4A6872A5B394E9782E2E" xlink:to="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_53299CD7E89A10D2DDDEB394E97909C7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB" xlink:to="loc_us-gaap_MaximumMember_53299CD7E89A10D2DDDEB394E97909C7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_7FF995F77F823E869CABB394E9793BA3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_C1B00367BF747F1BF7FAB394E97813BB" xlink:to="loc_us-gaap_MinimumMember_7FF995F77F823E869CABB394E9793BA3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_069CBE94E40F002109BCB394E979283A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_us-gaap_FairValueInputsDiscountRate_069CBE94E40F002109BCB394E979283A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PercentageOfIncreaseDecreaseInDiscountRate" xlink:label="loc_opk_PercentageOfIncreaseDecreaseInDiscountRate_CDFB8D7FE02ED36CF22FB394E979FCDA" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_opk_PercentageOfIncreaseDecreaseInDiscountRate_CDFB8D7FE02ED36CF22FB394E979FCDA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_E72177E4976A67746A01B394E9795ADB" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_E72177E4976A67746A01B394E9795ADB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PercentageOfIncreaseDecreaseInFutureSales" xlink:label="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_A6C21E332A95AB08ED89B394E97946F0" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_A6C21E332A95AB08ED89B394E97946F0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_4EF29B8C5C4894A786A5B394E97939DD" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_4EF29B8C5C4894A786A5B394E97939DD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_A1E79AB3C8F02B9A3918B394E979F5C1" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9AA3235F506C3AC02245B394E9795395" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_A1E79AB3C8F02B9A3918B394E979F5C1" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxes" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails1" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails2" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails3" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails4" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetails5" xlink:type="extended">
<loc xlink:href="opk-20141231.xsd#opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionLineItems" xlink:label="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionLineItems_69E65699C27868303EAE947E50FFDCEE" xlink:type="locator"/>
<loc xlink:href="opk-20141231.xsd#opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionTable" xlink:label="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionTable_48785AA7110C747787D7947E50FFEF9C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionLineItems_69E65699C27868303EAE947E50FFDCEE" xlink:to="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionTable_48785AA7110C747787D7947E50FFEF9C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_36471A8E40A5292F40CA947E50FF893D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionTable_48785AA7110C747787D7947E50FFEF9C" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_36471A8E40A5292F40CA947E50FF893D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_36471A8E40A5292F40CA947E50FF893D" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_36471A8E40A5292F40CA947E50FF893D" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_35FFE35BECB88660C808947E50FFD2B1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228" xlink:to="loc_us-gaap_DomesticCountryMember_35FFE35BECB88660C808947E50FFD2B1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_7976726FFCDBC1D5D4F2947E50FF2A5A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_8BA423FFE15DA81BB7B8947E50FF0228" xlink:to="loc_us-gaap_ForeignCountryMember_7976726FFCDBC1D5D4F2947E50FF2A5A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ReconciliationOfLongLivedAssetsToConsolidatedAsPerIncomeTaxJurisdictionAbstract" xlink:label="loc_opk_ReconciliationOfLongLivedAssetsToConsolidatedAsPerIncomeTaxJurisdictionAbstract_CF63604D1317F288B4AF947E51005F54" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_ScheduleOfLongLivedAssetsAsPerIncomeTaxJurisdictionLineItems_69E65699C27868303EAE947E50FFDCEE" xlink:to="loc_opk_ReconciliationOfLongLivedAssetsToConsolidatedAsPerIncomeTaxJurisdictionAbstract_CF63604D1317F288B4AF947E51005F54" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D6A7C160583B90A00C77947E5100A701" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_ReconciliationOfLongLivedAssetsToConsolidatedAsPerIncomeTaxJurisdictionAbstract_CF63604D1317F288B4AF947E51005F54" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D6A7C160583B90A00C77947E5100A701" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PropertyPlantEquipmentandInvestmentPropertyNet" xlink:label="loc_opk_PropertyPlantEquipmentandInvestmentPropertyNet_0A8D20C567A406E702BE947E50FF5765" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_D6A7C160583B90A00C77947E5100A701" xlink:to="loc_opk_PropertyPlantEquipmentandInvestmentPropertyNet_0A8D20C567A406E702BE947E50FF5765" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_CFB88130179D6A213236C6F6BE542019" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_CFB88130179D6A213236C6F6BE542019" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_CFB88130179D6A213236C6F6BE542019" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_CFB88130179D6A213236C6F6BE542019" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_42FF197C75BF438FF63FC6F6BE55C81D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46" xlink:to="loc_us-gaap_DomesticCountryMember_42FF197C75BF438FF63FC6F6BE55C81D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_E4EA15EFB16E8F73822DC6F6BE556479" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_E4EA15EFB16E8F73822DC6F6BE556479" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_58BA93D1DC6D2C5A90CEC6F6BE550779" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9C419C5CF72C2048E482C6F6BE544C46" xlink:to="loc_us-gaap_ForeignCountryMember_58BA93D1DC6D2C5A90CEC6F6BE550779" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_4D498F57C0B780D6B50AC6F6BE5551EE" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_4D498F57C0B780D6B50AC6F6BE5551EE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_EB7A203BC2C4A1460761C6F6BE55802F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_4D498F57C0B780D6B50AC6F6BE5551EE" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_EB7A203BC2C4A1460761C6F6BE55802F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_EB7A203BC2C4A1460761C6F6BE55802F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_4D498F57C0B780D6B50AC6F6BE5551EE" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_EB7A203BC2C4A1460761C6F6BE55802F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchMember" xlink:label="loc_us-gaap_ResearchMember_9100FC8B44C904F235CAC6F6BE55C416" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_EB7A203BC2C4A1460761C6F6BE55802F" xlink:to="loc_us-gaap_ResearchMember_9100FC8B44C904F235CAC6F6BE55C416" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_27D50B24EFF5B70E5B7DC6F6BE5597DB" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:to="loc_us-gaap_RangeAxis_27D50B24EFF5B70E5B7DC6F6BE5597DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_27D50B24EFF5B70E5B7DC6F6BE5597DB" xlink:to="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_27D50B24EFF5B70E5B7DC6F6BE5597DB" xlink:to="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_3D7B5A209A79DECF0DBAC6F6BE55ED90" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC" xlink:to="loc_us-gaap_MinimumMember_3D7B5A209A79DECF0DBAC6F6BE55ED90" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_AB2D1F129229AC497D2BC6F6BE55698A" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_B80F48761C1325E05F1DC6F6BE556DAC" xlink:to="loc_us-gaap_MaximumMember_AB2D1F129229AC497D2BC6F6BE55698A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_E5768DA745118C8EC1E6C6F6BE56C953" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CFDA8B6AB4268B50D74DC6F6BE547DBB" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_E5768DA745118C8EC1E6C6F6BE56C953" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3E2F06EE65BB67AFDD39C6F6BE5612EC_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E5768DA745118C8EC1E6C6F6BE56C953" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3E2F06EE65BB67AFDD39C6F6BE5612EC_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3E2F06EE65BB67AFDD39C6F6BE5612EC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E5768DA745118C8EC1E6C6F6BE56C953" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3E2F06EE65BB67AFDD39C6F6BE5612EC" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_3119AAB36FE0D25CC18AC6F6BE56865D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3E2F06EE65BB67AFDD39C6F6BE5612EC" xlink:to="loc_opk_OPKOBiologicsMember_3119AAB36FE0D25CC18AC6F6BE56865D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_2F2541496B1A7358E25BC6F6BE56B636" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_us-gaap_OperatingLossCarryforwards_2F2541496B1A7358E25BC6F6BE56B636" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_8BBB8A507AA11A116B40C6F6BE56CD2C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_8BBB8A507AA11A116B40C6F6BE56CD2C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DeferredTaxAssetsTaxDeferredExpenseCompensationandBenefitsSharebasedCompensationCostUnrecognized" xlink:label="loc_opk_DeferredTaxAssetsTaxDeferredExpenseCompensationandBenefitsSharebasedCompensationCostUnrecognized_BD554259DC33EB07A912C6F6BE56F4CE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_opk_DeferredTaxAssetsTaxDeferredExpenseCompensationandBenefitsSharebasedCompensationCostUnrecognized_BD554259DC33EB07A912C6F6BE56F4CE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TaxCreditCarryforwardExpirationPeriod" xlink:label="loc_opk_TaxCreditCarryforwardExpirationPeriod_634DBB4421933FE09067C6F6BE566343" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_opk_TaxCreditCarryforwardExpirationPeriod_634DBB4421933FE09067C6F6BE566343" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsResultingInNetOperatingLossCarryforward" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsResultingInNetOperatingLossCarryforward_E81653D4D8E42E755575C6F6BE565729" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsResultingInNetOperatingLossCarryforward_E81653D4D8E42E755575C6F6BE565729" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_257547449FDBD6BB7473C6F6BE56EA28" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_71490FFBF61F21D58410C6F6BE5672F2" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_257547449FDBD6BB7473C6F6BE56EA28" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/IncomeTaxesTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/Leases" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/LeasesDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/LeasesDetailsTextual" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/LeasesTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/LossPerShare" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/LossPerShareDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_D26BD89C4D2221DF734102CBF4B19F2F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_D26BD89C4D2221DF734102CBF4B19F2F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_DAA268CDE036DD3898F702CBF4B13C42" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_D26BD89C4D2221DF734102CBF4B19F2F" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_DAA268CDE036DD3898F702CBF4B13C42" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B207C34E4647BEB9637202CBF4B18186_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_DAA268CDE036DD3898F702CBF4B13C42" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B207C34E4647BEB9637202CBF4B18186_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B207C34E4647BEB9637202CBF4B18186" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_DAA268CDE036DD3898F702CBF4B13C42" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B207C34E4647BEB9637202CBF4B18186" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_2E1E05F2F1A3182C52DA02CBF4B12258" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B207C34E4647BEB9637202CBF4B18186" xlink:to="loc_us-gaap_CommonStockMember_2E1E05F2F1A3182C52DA02CBF4B12258" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_7134F8C006921D7405FA02CBF4B1EE76" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_7134F8C006921D7405FA02CBF4B1EE76" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_7D48650158DB213C526402CBF4B196A3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:to="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_7D48650158DB213C526402CBF4B196A3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_1D8BF1A39E0E004721CB02CBF4B15563" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:to="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_1D8BF1A39E0E004721CB02CBF4B15563" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SharesSurrenderedInLieuOfCashPayment" xlink:label="loc_opk_SharesSurrenderedInLieuOfCashPayment_5660AD3B7E50E148AD6502CBF4B104AC" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_10E7A0D02E910F31748E02CBF4B1A9DB" xlink:to="loc_opk_SharesSurrenderedInLieuOfCashPayment_5660AD3B7E50E148AD6502CBF4B104AC" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/RelatedPartyTransactions" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/RelatedPartyTransactionsTextualDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_BBB217C8704704AB65ABCBC529CDA2B8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_invest_InvestmentAxis_BBB217C8704704AB65ABCBC529CDA2B8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_invest_InvestmentAxis_BBB217C8704704AB65ABCBC529CDA2B8" xlink:to="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_invest_InvestmentAxis_BBB217C8704704AB65ABCBC529CDA2B8" xlink:to="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SevionMember" xlink:label="loc_opk_SevionMember_D2F0FB4E430D24E761BECBC569608DBD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541" xlink:to="loc_opk_SevionMember_D2F0FB4E430D24E761BECBC569608DBD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_79835B46A9DB3E5C918ACBC52A70CE60" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_invest_InvestmentDomain_3FB92148E16D61E299C2CBC52B13C541" xlink:to="loc_opk_CocrystalMember_79835B46A9DB3E5C918ACBC52A70CE60" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_49D8937E3BF34D5568C4CBC4BD5A1533" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_StatementScenarioAxis_49D8937E3BF34D5568C4CBC4BD5A1533" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_D834BA1E8370400DEA99CBC4BD5A563C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_49D8937E3BF34D5568C4CBC4BD5A1533" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_D834BA1E8370400DEA99CBC4BD5A563C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_D834BA1E8370400DEA99CBC4BD5A563C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_49D8937E3BF34D5568C4CBC4BD5A1533" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_D834BA1E8370400DEA99CBC4BD5A563C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_00A30267258D0E200643CBC4BD5A7A3B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_D834BA1E8370400DEA99CBC4BD5A563C" xlink:to="loc_us-gaap_ScenarioForecastMember_00A30267258D0E200643CBC4BD5A7A3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_8804B8E65C844FB26C7ACBC4BD5B7A77" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_8804B8E65C844FB26C7ACBC4BD5B7A77" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_8804B8E65C844FB26C7ACBC4BD5B7A77" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_8804B8E65C844FB26C7ACBC4BD5B7A77" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FTCFilingsMember" xlink:label="loc_opk_FTCFilingsMember_5954D8EAB262ECAEBF25CBC4BD5B19B0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_opk_FTCFilingsMember_5954D8EAB262ECAEBF25CBC4BD5B19B0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LabSpaceAgreementMember" xlink:label="loc_opk_LabSpaceAgreementMember_3CDA3702C2C1F84119E0CBC4BD5B24A9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_opk_LabSpaceAgreementMember_3CDA3702C2C1F84119E0CBC4BD5B24A9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConsultingAgreementMember" xlink:label="loc_opk_ConsultingAgreementMember_74464D2BBBD5C52800F3CBC4BD5B4EBC" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_opk_ConsultingAgreementMember_74464D2BBBD5C52800F3CBC4BD5B4EBC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LoansReceivableMember" xlink:label="loc_us-gaap_LoansReceivableMember_BDC58C8077615DB5CE6ECBC4BD5B194C" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_us-gaap_LoansReceivableMember_BDC58C8077615DB5CE6ECBC4BD5B194C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LicenseAgreementEarlyTerminationFeeMember" xlink:label="loc_opk_LicenseAgreementEarlyTerminationFeeMember_FE11BAC10377ACB66B0CCBC4BD5BE3A4" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_opk_LicenseAgreementEarlyTerminationFeeMember_FE11BAC10377ACB66B0CCBC4BD5BE3A4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ReimbursementOfTravelExpenseMember" xlink:label="loc_opk_ReimbursementOfTravelExpenseMember_AB135CE53CAF7178DC4ACBC4BD5B0F14" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_D097DF33C08A078E842BCBC4BD5B33D9" xlink:to="loc_opk_ReimbursementOfTravelExpenseMember_AB135CE53CAF7178DC4ACBC4BD5B0F14" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3717476A68369108B515CBC4BD5B5296" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3717476A68369108B515CBC4BD5B5296" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3717476A68369108B515CBC4BD5B5296" xlink:to="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3717476A68369108B515CBC4BD5B5296" xlink:to="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeMember" xlink:label="loc_us-gaap_EquityMethodInvesteeMember_80867F12CB9844415925CBC4BD5B097C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_us-gaap_EquityMethodInvesteeMember_80867F12CB9844415925CBC4BD5B097C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DrFrostMember" xlink:label="loc_opk_DrFrostMember_A6CC5C07213FBA0F80B5CBC4BD5B73A5" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_DrFrostMember_A6CC5C07213FBA0F80B5CBC4BD5B73A5" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_Dr.HsiaoMember" xlink:label="loc_opk_Dr.HsiaoMember_27740D3EFDA01CC24E9FCBC4BD5BBEED" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_Dr.HsiaoMember_27740D3EFDA01CC24E9FCBC4BD5BBEED" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member" xlink:label="loc_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_9E5E4E505C012085FB31CBC4BD5B5262" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_9E5E4E505C012085FB31CBC4BD5B5262" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AviPropertiesLlcMember" xlink:label="loc_opk_AviPropertiesLlcMember_DE5E7592C44AB8FF9BAACBC4BD5B21FA" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_AviPropertiesLlcMember_DE5E7592C44AB8FF9BAACBC4BD5B21FA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TevaPharmaceuticalIndustriesMember" xlink:label="loc_opk_TevaPharmaceuticalIndustriesMember_177A4AE9C65F979D08B7CBC4BD5B6848" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_TevaPharmaceuticalIndustriesMember_177A4AE9C65F979D08B7CBC4BD5B6848" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ScrippsResearchInstituteMember" xlink:label="loc_opk_ScrippsResearchInstituteMember_9A22E7665FBDEA1ED8F4CBC4BD5C5EBD" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_ScrippsResearchInstituteMember_9A22E7665FBDEA1ED8F4CBC4BD5C5EBD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_GammaTrustMember" xlink:label="loc_opk_GammaTrustMember_1699B04CEA1EFBE530CBCBC4BD5C07A2" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_GammaTrustMember_1699B04CEA1EFBE530CBCBC4BD5C07A2" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_HsuGammaMember" xlink:label="loc_opk_HsuGammaMember_41FA3AA44D52D36E99E2CBC4BD5C827B" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_HsuGammaMember_41FA3AA44D52D36E99E2CBC4BD5C827B" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DrLernerMember" xlink:label="loc_opk_DrLernerMember_D08B24E31AB649A8C839CBC4BD5C6541" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_DrLernerMember_D08B24E31AB649A8C839CBC4BD5C6541" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FabrusMember" xlink:label="loc_opk_FabrusMember_63180145BD2CBF01AD09CBC4BD5C6A44" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_FabrusMember_63180145BD2CBF01AD09CBC4BD5C6A44" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_GammaTrustandHsuGammaMember" xlink:label="loc_opk_GammaTrustandHsuGammaMember_3D5485CA26E5FAC20868CBC4BD5CA645" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_GammaTrustandHsuGammaMember_3D5485CA26E5FAC20868CBC4BD5CA645" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AcademiaSinicaMember" xlink:label="loc_opk_AcademiaSinicaMember_3AE23E128ED56029C354CBC4BD5C9255" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_AcademiaSinicaMember_3AE23E128ED56029C354CBC4BD5C9255" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FrostGroupLLCMember" xlink:label="loc_opk_FrostGroupLLCMember_152CA051A778C6369A29CBC4BD5C5DE2" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_FrostGroupLLCMember_152CA051A778C6369A29CBC4BD5C5DE2" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FrostRealEstateHoldingsLLCMember" xlink:label="loc_opk_FrostRealEstateHoldingsLLCMember_0121FF79A7B451B2C609CBC4BD5C5FA7" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_FrostRealEstateHoldingsLLCMember_0121FF79A7B451B2C609CBC4BD5C5FA7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_Mr.RubinMember" xlink:label="loc_opk_Mr.RubinMember_ED52562450217C3B68B0CBC4BD5CD0EB" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_opk_Mr.RubinMember_ED52562450217C3B68B0CBC4BD5CD0EB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_8292FCC323FC5F32CE9FCBC4BD5CBFDB" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_460734BA7E2FF8FB7946CBC4BD5B468E" xlink:to="loc_us-gaap_DirectorMember_8292FCC323FC5F32CE9FCBC4BD5CBFDB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A224281F516B5FDE519DCBC4BD5C9A9E" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A224281F516B5FDE519DCBC4BD5C9A9E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A224281F516B5FDE519DCBC4BD5C9A9E" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A224281F516B5FDE519DCBC4BD5C9A9E" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ARNOMember" xlink:label="loc_opk_ARNOMember_BF7A10E876CDBA13DCBECBC4BD5CB4DD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_ARNOMember_BF7A10E876CDBA13DCBECBC4BD5CB4DD" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ZebraMember" xlink:label="loc_opk_ZebraMember_5A5E3A991FC9F4B906EECBC4BD5C43A8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_ZebraMember_5A5E3A991FC9F4B906EECBC4BD5C43A8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ChromadexCorporationMember" xlink:label="loc_opk_ChromadexCorporationMember_BEA5035F4209BFF858F8CBC4BD5D49F6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_ChromadexCorporationMember_BEA5035F4209BFF858F8CBC4BD5D49F6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="loc_opk_BiozonePharmaceuticalsIncMember_F79481528D9759877585CBC4BD5D9235" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_BiozonePharmaceuticalsIncMember_F79481528D9759877585CBC4BD5D9235" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BiozoneMember" xlink:label="loc_opk_BiozoneMember_CE500EACAFC87DD96831CBC4BD5D65B7" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_BiozoneMember_CE500EACAFC87DD96831CBC4BD5D65B7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_MusclePharmCorporationMember" xlink:label="loc_opk_MusclePharmCorporationMember_1D5CA42F478F49B8FAE1CBC4BD5D249A" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_MusclePharmCorporationMember_1D5CA42F478F49B8FAE1CBC4BD5D249A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FabrusIncMember" xlink:label="loc_opk_FabrusIncMember_B35DCCA5DDF8D013D960CBC4BD5DF9DB" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_FabrusIncMember_B35DCCA5DDF8D013D960CBC4BD5DF9DB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_B05DE4E0F7282F4AE479CBC4BD5D30C8" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_CocrystalMember_B05DE4E0F7282F4AE479CBC4BD5D30C8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SorrentoMember" xlink:label="loc_opk_SorrentoMember_EE71DCE7A92BF8FCC3C9CBC4BD5DFCF3" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_F462005C2FBD09A6CC7DCBC4BD5C6A9C" xlink:to="loc_opk_SorrentoMember_EE71DCE7A92BF8FCC3C9CBC4BD5DFCF3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_522493BFAE35430B9E9ECBC4BD5D7256" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_522493BFAE35430B9E9ECBC4BD5D7256" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_522493BFAE35430B9E9ECBC4BD5D7256" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_522493BFAE35430B9E9ECBC4BD5D7256" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OneYearWarrantsMember" xlink:label="loc_opk_OneYearWarrantsMember_4D9D96ED1A96339A68ECCBC4BD5DCC5E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC" xlink:to="loc_opk_OneYearWarrantsMember_4D9D96ED1A96339A68ECCBC4BD5DCC5E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FiveYearWarrantsMember" xlink:label="loc_opk_FiveYearWarrantsMember_124FE5EB2E6F904C74BFCBC4BD5DC05F" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9C8053ADAB54A0630FE1CBC4BD5DCCCC" xlink:to="loc_opk_FiveYearWarrantsMember_124FE5EB2E6F904C74BFCBC4BD5DC05F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_44574C8A920580CA7AEDCBC4BD5D9738" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_44574C8A920580CA7AEDCBC4BD5D9738" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_44574C8A920580CA7AEDCBC4BD5D9738" xlink:to="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_44574C8A920580CA7AEDCBC4BD5D9738" xlink:to="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_7B3A9288D1FF89087FB8CBC4BD5D21EA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_7B3A9288D1FF89087FB8CBC4BD5D21EA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_50D38A98586124849D4BCBC4BD5DBF33" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:to="loc_us-gaap_RestrictedStockMember_50D38A98586124849D4BCBC4BD5DBF33" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertiblePreferredStockMember" xlink:label="loc_us-gaap_ConvertiblePreferredStockMember_BB1690D14D3A9A2F92F9CBC4BD5DC2AE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:to="loc_us-gaap_ConvertiblePreferredStockMember_BB1690D14D3A9A2F92F9CBC4BD5DC2AE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_E96962D9B9D4F0819F3FCBC4BD5D3373" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:to="loc_us-gaap_CommonStockMember_E96962D9B9D4F0819F3FCBC4BD5D3373" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SeriesBConvertiblePreferredStockMember" xlink:label="loc_opk_SeriesBConvertiblePreferredStockMember_FC2EFB60224E22F36E42CBC4BD5D0A06" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_06916E913E3B0D1C4210CBC4BD5D7A7B" xlink:to="loc_opk_SeriesBConvertiblePreferredStockMember_FC2EFB60224E22F36E42CBC4BD5D0A06" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_927DFBD89E1F12D6E6E0CBC4BD5DF7DD" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_dei_LegalEntityAxis_927DFBD89E1F12D6E6E0CBC4BD5DF7DD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_927DFBD89E1F12D6E6E0CBC4BD5DF7DD" xlink:to="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_927DFBD89E1F12D6E6E0CBC4BD5DF7DD" xlink:to="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PROLORMember" xlink:label="loc_opk_PROLORMember_B128C64BDDC5BA1B1B43CBC4BD5EB0F6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E" xlink:to="loc_opk_PROLORMember_B128C64BDDC5BA1B1B43CBC4BD5EB0F6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_4879FED9227E33F1722FCBC4BD5E8570" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E" xlink:to="loc_opk_OPKOBiologicsMember_4879FED9227E33F1722FCBC4BD5E8570" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_556E80761AD3448C2BB8CBC4BD5E4BBA" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FDA2896E21E1C22B62BDCBC4BD5E0A2E" xlink:to="loc_opk_FineTechMember_556E80761AD3448C2BB8CBC4BD5E4BBA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_82D73B1BB247B639137ACBC4BD5E6B65" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_82D73B1BB247B639137ACBC4BD5E6B65" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_DB091A419503C99C6074CBC4BD5E25D1_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_82D73B1BB247B639137ACBC4BD5E6B65" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_DB091A419503C99C6074CBC4BD5E25D1_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_DB091A419503C99C6074CBC4BD5E25D1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_82D73B1BB247B639137ACBC4BD5E6B65" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_DB091A419503C99C6074CBC4BD5E25D1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_D1888CEB47789FB07F1BCBC4BD5E7640" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_DB091A419503C99C6074CBC4BD5E25D1" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_D1888CEB47789FB07F1BCBC4BD5E7640" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_9BB4E27748CF2DD18CF9CBC4BD5E6615" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_F38CF93F9027647A8A4FCBC4BD5A68B9" xlink:to="loc_us-gaap_DebtInstrumentAxis_9BB4E27748CF2DD18CF9CBC4BD5E6615" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_D1F81CE9A5D71127FB1CCBC4BD5E4C9F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_9BB4E27748CF2DD18CF9CBC4BD5E6615" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_D1F81CE9A5D71127FB1CCBC4BD5E4C9F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_D1F81CE9A5D71127FB1CCBC4BD5E4C9F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_9BB4E27748CF2DD18CF9CBC4BD5E6615" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_D1F81CE9A5D71127FB1CCBC4BD5E4C9F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_D4D60408D6B8C394D764CBC4BD5E6B0C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_D1F81CE9A5D71127FB1CCBC4BD5E4C9F" xlink:to="loc_opk_NotesDueFebruary12033Member_D4D60408D6B8C394D764CBC4BD5E6B0C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PaymentsforFilingFees" xlink:label="loc_opk_PaymentsforFilingFees_A965C9452C4D9D22460ECBC4BD5E88E8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_PaymentsforFilingFees_A965C9452C4D9D22460ECBC4BD5E88E8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_85D6C08930BF42CBA6E9CBC4BD5E5C23" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_85D6C08930BF42CBA6E9CBC4BD5E5C23" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PrivatePlacementFinancing" xlink:label="loc_opk_PrivatePlacementFinancing_6EB1B43EBAE98062CF56CBC4BD5E74D7" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_PrivatePlacementFinancing_6EB1B43EBAE98062CF56CBC4BD5E74D7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InvestmentOwnedBalanceShares" xlink:label="loc_us-gaap_InvestmentOwnedBalanceShares_583A165F3B364B4725D4CBC4BD5EA455" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_InvestmentOwnedBalanceShares_583A165F3B364B4725D4CBC4BD5EA455" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ClassOfWarrantOrRightWarrantExpirationPeriod" xlink:label="loc_opk_ClassOfWarrantOrRightWarrantExpirationPeriod_5818CAD4F7959925A9AECBC4BD5E5FD2" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_ClassOfWarrantOrRightWarrantExpirationPeriod_5818CAD4F7959925A9AECBC4BD5E5FD2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FB15AA7F7F579FBF4BB1CBC4BD5E24E9" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_FB15AA7F7F579FBF4BB1CBC4BD5E24E9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights_C746738354EB301AC3B1CBC4BD5E4702" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights_C746738354EB301AC3B1CBC4BD5E4702" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_InvestmentAgreementRequirementtoHoldRightstoBoardMinimumStockPercentage" xlink:label="loc_opk_InvestmentAgreementRequirementtoHoldRightstoBoardMinimumStockPercentage_9005A49BFD82EA0B646CCBC4BD5ED288" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_InvestmentAgreementRequirementtoHoldRightstoBoardMinimumStockPercentage_9005A49BFD82EA0B646CCBC4BD5ED288" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionNegotiationPeriod" xlink:label="loc_opk_RelatedPartyTransactionNegotiationPeriod_203E00313797CB57ACC2CBC4BD5E2C4B" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionNegotiationPeriod_203E00313797CB57ACC2CBC4BD5E2C4B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_E021A1ECBC51371A305ECBC4BD5F0CB3" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_E021A1ECBC51371A305ECBC4BD5F0CB3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_SharesReceivedAsGift" xlink:label="loc_opk_SharesReceivedAsGift_09A438E656D1DD6BA59ECBC4BD5FF676" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_SharesReceivedAsGift_09A438E656D1DD6BA59ECBC4BD5FF676" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AreaOfRealEstateProperty" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_98CFD2F23EC912D64A09CBC4BD5F91AE" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_AreaOfRealEstateProperty_98CFD2F23EC912D64A09CBC4BD5F91AE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LessorLeasingArrangementsOperatingLeasesTermOfContract" xlink:label="loc_us-gaap_LessorLeasingArrangementsOperatingLeasesTermOfContract_555DD748A0ABCA6ED131CBC4BD5F0098" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_LessorLeasingArrangementsOperatingLeasesTermOfContract_555DD748A0ABCA6ED131CBC4BD5F0098" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OperatingLeasesAnnualMinimumPayment" xlink:label="loc_opk_OperatingLeasesAnnualMinimumPayment_F684E1845BA31823859FCBC4BD5F4751" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OperatingLeasesAnnualMinimumPayment_F684E1845BA31823859FCBC4BD5F4751" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OwnershipPercentageHeldByMembers" xlink:label="loc_opk_OwnershipPercentageHeldByMembers_6EDC41DF0D53C3679781CBC4BD5F8E28" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OwnershipPercentageHeldByMembers_6EDC41DF0D53C3679781CBC4BD5F8E28" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_2F2D3A9166177CD6B206CBC4BD5FF361" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_2F2D3A9166177CD6B206CBC4BD5FF361" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract" xlink:label="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract_1E8E9BFFDAC79C60F444CBC4BD5F82CA" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract_1E8E9BFFDAC79C60F444CBC4BD5F82CA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AreaOfLand" xlink:label="loc_us-gaap_AreaOfLand_C4633776C649D8E57612CBC4BD5FA2EE" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_AreaOfLand_C4633776C649D8E57612CBC4BD5FA2EE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearOne" xlink:label="loc_opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearOne_706834AC59961043CFECCBC4BD5FF1E8" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearOne_706834AC59961043CFECCBC4BD5FF1E8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LesseeLeasingArrangementsMinimumPercentageIncreaseInConsumerPriceIndexRequiredToIncreaseRentExpense" xlink:label="loc_opk_LesseeLeasingArrangementsMinimumPercentageIncreaseInConsumerPriceIndexRequiredToIncreaseRentExpense_003477DC555CA13ACB84CBC4BD5F9375" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_LesseeLeasingArrangementsMinimumPercentageIncreaseInConsumerPriceIndexRequiredToIncreaseRentExpense_003477DC555CA13ACB84CBC4BD5F9375" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_5ED0D8DF8D815672C10ECBC4BD5FD558" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_RevenueFromRelatedParties_5ED0D8DF8D815672C10ECBC4BD5FD558" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionAgreementTermsAnnualFundForResearch" xlink:label="loc_opk_RelatedPartyTransactionAgreementTermsAnnualFundForResearch_670ECDBFB0F14D333217CBC4BD5F407E" xlink:type="locator"/>
<definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionAgreementTermsAnnualFundForResearch_670ECDBFB0F14D333217CBC4BD5F407E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionAgreementTermsResearchMaturityPeriod" xlink:label="loc_opk_RelatedPartyTransactionAgreementTermsResearchMaturityPeriod_E8CC6984286D9A96F9E8CBC4BD5F80A3" xlink:type="locator"/>
<definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionAgreementTermsResearchMaturityPeriod_E8CC6984286D9A96F9E8CBC4BD5F80A3" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTranscationAgreementTermsFurtherDevelopmentofTechnology" xlink:label="loc_opk_RelatedPartyTranscationAgreementTermsFurtherDevelopmentofTechnology_45B33DC99A2AD822A81FCBC4BD5FD120" xlink:type="locator"/>
<definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTranscationAgreementTermsFurtherDevelopmentofTechnology_45B33DC99A2AD822A81FCBC4BD5FD120" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod" xlink:label="loc_opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod_C1FD1FDC1AD47273D018CBC4BD5F211F" xlink:type="locator"/>
<definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTranscationAgreementTermsFutherDevelopmentofTechnologyMaturityPeriod_C1FD1FDC1AD47273D018CBC4BD5F211F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E23BA449600A7DF74FB2CBC4BD5F4259" xlink:type="locator"/>
<definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E23BA449600A7DF74FB2CBC4BD5F4259" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_807572E634E153DE9F70CBC4BD605D23" xlink:type="locator"/>
<definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_807572E634E153DE9F70CBC4BD605D23" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesReceivableInterestRateStatedPercentage" xlink:label="loc_opk_NotesReceivableInterestRateStatedPercentage_D82C25D12FF1DDE002F6CBC4BD60DD4A" xlink:type="locator"/>
<definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_NotesReceivableInterestRateStatedPercentage_D82C25D12FF1DDE002F6CBC4BD60DD4A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesReceviableConvertibletoCommonStockConversionPrice" xlink:label="loc_opk_NotesReceviableConvertibletoCommonStockConversionPrice_84DB78CD5E82CD08D063CBC4BD607245" xlink:type="locator"/>
<definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_NotesReceviableConvertibletoCommonStockConversionPrice_84DB78CD5E82CD08D063CBC4BD607245" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ClassofWarrantorRightExpirationPeriod" xlink:label="loc_opk_ClassofWarrantorRightExpirationPeriod_3020E79694528211D25ECBC4BD608B5A" xlink:type="locator"/>
<definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_ClassofWarrantorRightExpirationPeriod_3020E79694528211D25ECBC4BD608B5A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentWarrantsExercisePrice" xlink:label="loc_invest_InvestmentWarrantsExercisePrice_746D888AE40EA5688683CBC4BD602642" xlink:type="locator"/>
<definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_invest_InvestmentWarrantsExercisePrice_746D888AE40EA5688683CBC4BD602642" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_CA3623D5A3687905CAE2CBC4BD60F49F" xlink:type="locator"/>
<definitionArc order="32" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_CA3623D5A3687905CAE2CBC4BD60F49F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BiozonePharmaceuticalsWarrantsExercised" xlink:label="loc_opk_BiozonePharmaceuticalsWarrantsExercised_1BB3C52122F49CB6B698CBC4BD601462" xlink:type="locator"/>
<definitionArc order="33" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_BiozonePharmaceuticalsWarrantsExercised_1BB3C52122F49CB6B698CBC4BD601462" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NoncashorPartNoncashDivestitureSharesReceived" xlink:label="loc_opk_NoncashorPartNoncashDivestitureSharesReceived_2F0AAB739BD6226AB59BCBC4BD60358E" xlink:type="locator"/>
<definitionArc order="34" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_NoncashorPartNoncashDivestitureSharesReceived_2F0AAB739BD6226AB59BCBC4BD60358E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesIssued1" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesIssued1_714B8BC3B1507276EEBCCBC4BD60DE09" xlink:type="locator"/>
<definitionArc order="35" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesIssued1_714B8BC3B1507276EEBCCBC4BD60DE09" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_StockConversionCommonSharesIssueduponConversion" xlink:label="loc_opk_StockConversionCommonSharesIssueduponConversion_0D72121867920A70625DCBC4BD607D7F" xlink:type="locator"/>
<definitionArc order="36" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_StockConversionCommonSharesIssueduponConversion_0D72121867920A70625DCBC4BD607D7F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentAmountofFinancingIncludingRelatedParties" xlink:label="loc_opk_EquityMethodInvestmentAmountofFinancingIncludingRelatedParties_1180DDC4A54001CD6FEFCBC4BD6032BF" xlink:type="locator"/>
<definitionArc order="37" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_EquityMethodInvestmentAmountofFinancingIncludingRelatedParties_1180DDC4A54001CD6FEFCBC4BD6032BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedParties" xlink:label="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_14542D6F751FA0166080CBC4BD608A67" xlink:type="locator"/>
<definitionArc order="38" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_14542D6F751FA0166080CBC4BD608A67" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionRate" xlink:label="loc_us-gaap_RelatedPartyTransactionRate_E02012001183600FE442CBC4BD605825" xlink:type="locator"/>
<definitionArc order="39" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_RelatedPartyTransactionRate_E02012001183600FE442CBC4BD605825" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DueToRelatedPartyOverTermOfAgreement" xlink:label="loc_opk_DueToRelatedPartyOverTermOfAgreement_0565EC1B9C892D8B4F7FCBC4BD606D7E" xlink:type="locator"/>
<definitionArc order="40" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_DueToRelatedPartyOverTermOfAgreement_0565EC1B9C892D8B4F7FCBC4BD606D7E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentNumberOfSharesPurchased" xlink:label="loc_opk_EquityMethodInvestmentNumberOfSharesPurchased_CD32212DD15914002BAFCBC4BD6040DE" xlink:type="locator"/>
<definitionArc order="41" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_EquityMethodInvestmentNumberOfSharesPurchased_CD32212DD15914002BAFCBC4BD6040DE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionPreviousInvestmentByGroupOfRelatedPartyInvestor" xlink:label="loc_opk_RelatedPartyTransactionPreviousInvestmentByGroupOfRelatedPartyInvestor_AD1F97A7ADFCFCE9487FCBC4BD606AFF" xlink:type="locator"/>
<definitionArc order="42" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionPreviousInvestmentByGroupOfRelatedPartyInvestor_AD1F97A7ADFCFCE9487FCBC4BD606AFF" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionAdditionalInvestmentPayableByGroupOfRelatedPartyInvestor" xlink:label="loc_opk_RelatedPartyTransactionAdditionalInvestmentPayableByGroupOfRelatedPartyInvestor_34DA2F92CC1D3BBA7EC6CBC4BD602D79" xlink:type="locator"/>
<definitionArc order="43" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionAdditionalInvestmentPayableByGroupOfRelatedPartyInvestor_34DA2F92CC1D3BBA7EC6CBC4BD602D79" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RelatedPartyTransactionNumberofEqualInstallmentsPayableforAdditionalInvestmentbyRelatedPartyInvestors" xlink:label="loc_opk_RelatedPartyTransactionNumberofEqualInstallmentsPayableforAdditionalInvestmentbyRelatedPartyInvestors_B3DC0EC72D8101654582CBC4BD604BD8" xlink:type="locator"/>
<definitionArc order="44" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_RelatedPartyTransactionNumberofEqualInstallmentsPayableforAdditionalInvestmentbyRelatedPartyInvestors_B3DC0EC72D8101654582CBC4BD604BD8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal" xlink:label="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_0B0105BE2792E054F8AACBC4BD602B57" xlink:type="locator"/>
<definitionArc order="45" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_0B0105BE2792E054F8AACBC4BD602B57" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty_0F87648E09012E36973ECBC4BD602FF6" xlink:type="locator"/>
<definitionArc order="46" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty_0F87648E09012E36973ECBC4BD602FF6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearFive" xlink:label="loc_opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearFive_47C03BC2A2DB33D4B4C2CBC4BD60640A" xlink:type="locator"/>
<definitionArc order="47" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OperatingLeasesFutureMinimumPaymentsDuePerMonthYearFive_47C03BC2A2DB33D4B4C2CBC4BD60640A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TenantReimbursements" xlink:label="loc_us-gaap_TenantReimbursements_085DCE394C7A513DB821CBC4BD610ACF" xlink:type="locator"/>
<definitionArc order="48" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_TenantReimbursements_085DCE394C7A513DB821CBC4BD610ACF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LesseeLeasingArrangementsOperatingLeasesRenewalTerm" xlink:label="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesRenewalTerm_11A32C8E1851A9BA4A4BCBC4BD615C46" xlink:type="locator"/>
<definitionArc order="49" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesRenewalTerm_11A32C8E1851A9BA4A4BCBC4BD615C46" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OperatingLeasesMonthlyPaymentsYearOne" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_38376DE470B2978C8B77CBC4BD61A4C7" xlink:type="locator"/>
<definitionArc order="50" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_38376DE470B2978C8B77CBC4BD61A4C7" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_OperatingLeasesMonthlyPaymentsYearFive" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_7FEFABCF67209F0A0E17CBC4BD6109BA" xlink:type="locator"/>
<definitionArc order="51" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_7FEFABCF67209F0A0E17CBC4BD6109BA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths" xlink:label="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_85F9924F97024E15692DCBC4BD617B90" xlink:type="locator"/>
<definitionArc order="52" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_85F9924F97024E15692DCBC4BD617B90" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_984B00E8D73C7DCB115ECBC4BD613B6D" xlink:type="locator"/>
<definitionArc order="53" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_6657EBFB4811C80F3951CBC4BD5E3424" xlink:to="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_984B00E8D73C7DCB115ECBC4BD613B6D" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/Segments" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SegmentsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7150004ED3EA91C1D1FDB394E9037FE8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7150004ED3EA91C1D1FDB394E9037FE8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_30AE67BB329F5B921C4CB394E903755C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7150004ED3EA91C1D1FDB394E9037FE8" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_30AE67BB329F5B921C4CB394E903755C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_30AE67BB329F5B921C4CB394E903755C" xlink:to="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_30AE67BB329F5B921C4CB394E903755C" xlink:to="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_C5149DD7986A1DE9AF64B394E903E05F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F" xlink:to="loc_opk_PharmaceuticalMember_C5149DD7986A1DE9AF64B394E903E05F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_D9A27F792867D1C36DFCB394E903F947" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_616D5C359660C137B7C1B394E903D85F" xlink:to="loc_opk_DiagnosticsMember_D9A27F792867D1C36DFCB394E903F947" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_7239E15BB67AD4111DA4B394E9036E1F" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7150004ED3EA91C1D1FDB394E9037FE8" xlink:to="loc_us-gaap_ConsolidationItemsAxis_7239E15BB67AD4111DA4B394E9036E1F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_7239E15BB67AD4111DA4B394E9036E1F" xlink:to="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_7239E15BB67AD4111DA4B394E9036E1F" xlink:to="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_A72B614566DEF71DE4FEB394E903133B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207" xlink:to="loc_us-gaap_OperatingSegmentsMember_A72B614566DEF71DE4FEB394E903133B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_84C9CDB2312DCEE07229B394E903F31C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207" xlink:to="loc_us-gaap_CorporateNonSegmentMember_84C9CDB2312DCEE07229B394E903F31C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaterialReconcilingItemsMember" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_FCAEF4B0F915C3C7FB3EB394E9031B57" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_8293B81B373A753AE17FB394E903C207" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_FCAEF4B0F915C3C7FB3EB394E9031B57" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_46804D9EACE8396B25D4B394E9036531" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7150004ED3EA91C1D1FDB394E9037FE8" xlink:to="loc_us-gaap_StatementGeographicalAxis_46804D9EACE8396B25D4B394E9036531" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_46804D9EACE8396B25D4B394E9036531" xlink:to="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_46804D9EACE8396B25D4B394E9036531" xlink:to="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_FA930F7DC18DDF4F207BB394E9037B79" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_US_FA930F7DC18DDF4F207BB394E9037B79" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_CL" xlink:label="loc_country_CL_018BDDDE243E9B2D73E0B394E903A402" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_CL_018BDDDE243E9B2D73E0B394E903A402" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_ES" xlink:label="loc_country_ES_9E81A545CFA37889EEE5B394E903121E" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_ES_9E81A545CFA37889EEE5B394E903121E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_IL" xlink:label="loc_country_IL_6AAEEAC977BA5AF29B1CB394E9037514" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_IL_6AAEEAC977BA5AF29B1CB394E9037514" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_MX" xlink:label="loc_country_MX_29E213CBA93D12162D42B394E903885D" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_MX_29E213CBA93D12162D42B394E903885D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_UY" xlink:label="loc_country_UY_DA04B45A5BA0D37BA57EB394E9032FC4" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BBE860D5610A3E7290C8B394E903A8E9" xlink:to="loc_country_UY_DA04B45A5BA0D37BA57EB394E9032FC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_52B17617DA801BDEF936B394E9036A3E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_52B17617DA801BDEF936B394E9036A3E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_248FB3998C1EDF4FA691B394E90459CE" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_SalesRevenueServicesNet_248FB3998C1EDF4FA691B394E90459CE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromTransferOfIntellectualProperty" xlink:label="loc_opk_RevenueFromTransferOfIntellectualProperty_B0D65A4E37A0EE3CC1D6B394E9043797" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_opk_RevenueFromTransferOfIntellectualProperty_B0D65A4E37A0EE3CC1D6B394E9043797" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_897175E8F7AF44537430B394E9040566" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_OperatingIncomeLoss_897175E8F7AF44537430B394E9040566" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_E7294A905BC7227933CDB394E904F789" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_E7294A905BC7227933CDB394E904F789" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_41A757AD74E850D8DFADB394E9049B99" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_GainLossOnInvestments_41A757AD74E850D8DFADB394E9049B99" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_B04A8297E32F8FDE1E2DB394E9046EFD" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_SalesRevenueNet_B04A8297E32F8FDE1E2DB394E9046EFD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_2CAA0CF27D2582907BB0B394E904393E" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_Assets_2CAA0CF27D2582907BB0B394E904393E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_CB933AE34136D23239E6B394E904D80A" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_C13D8541C256353FC4E6B394E903ECD7" xlink:to="loc_us-gaap_Goodwill_CB933AE34136D23239E6B394E904D80A" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/SegmentsDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_AF09760EF88F2D3ECA1803381D85723F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_AF09760EF88F2D3ECA1803381D85723F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_AF09760EF88F2D3ECA1803381D85723F" xlink:to="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_AF09760EF88F2D3ECA1803381D85723F" xlink:to="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_BA2BD97A35092135A44003381D85DD0A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43" xlink:to="loc_opk_PharmaceuticalMember_BA2BD97A35092135A44003381D85DD0A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_316C955FDD3CC6899D4E03381D8504A8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_380C772B23B4E229343303381D85CF43" xlink:to="loc_opk_DiagnosticsMember_316C955FDD3CC6899D4E03381D8504A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_383E4822A0D323F9DF5103381D851790" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:to="loc_us-gaap_ConsolidationItemsAxis_383E4822A0D323F9DF5103381D851790" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_CCDBF77DFE3ECA5A764B03381D857028_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_383E4822A0D323F9DF5103381D851790" xlink:to="loc_us-gaap_ConsolidationItemsDomain_CCDBF77DFE3ECA5A764B03381D857028_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_CCDBF77DFE3ECA5A764B03381D857028" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_383E4822A0D323F9DF5103381D851790" xlink:to="loc_us-gaap_ConsolidationItemsDomain_CCDBF77DFE3ECA5A764B03381D857028" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:label="loc_us-gaap_IntersegmentEliminationMember_7798C3076153DC8EB06B03381D85C458" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_CCDBF77DFE3ECA5A764B03381D857028" xlink:to="loc_us-gaap_IntersegmentEliminationMember_7798C3076153DC8EB06B03381D85C458" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_5739C6A56B6F236973B203381D8581A4" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_5739C6A56B6F236973B203381D8581A4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_87845109339458F5255403381D85617A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5739C6A56B6F236973B203381D8581A4" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_87845109339458F5255403381D85617A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_87845109339458F5255403381D85617A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5739C6A56B6F236973B203381D8581A4" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_87845109339458F5255403381D85617A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_AAB7CE7E04893C71067903381D858E1A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_87845109339458F5255403381D85617A" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_AAB7CE7E04893C71067903381D858E1A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_217FCA4C44E4413EE49E03381D85A4F9" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_970090B79128E685E7E303381D85F552" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_217FCA4C44E4413EE49E03381D85A4F9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_217FCA4C44E4413EE49E03381D85A4F9" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_217FCA4C44E4413EE49E03381D85A4F9" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_D6635CC60C2E8357276903381D8592A0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361" xlink:to="loc_us-gaap_SalesRevenueNetMember_D6635CC60C2E8357276903381D8592A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_9FD41550725001B3397303381D8BBCB3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_496BB21385C889D8770003381D85D361" xlink:to="loc_us-gaap_AccountsReceivableMember_9FD41550725001B3397303381D8BBCB3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_01D10E09E6BC17B24C7203381D8B12AB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_NumberOfReportableSegments_01D10E09E6BC17B24C7203381D8B12AB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NumberOfOperatingSegments" xlink:label="loc_us-gaap_NumberOfOperatingSegments_8B22026A09F5B600371103381D8B2EB9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_NumberOfOperatingSegments_8B22026A09F5B600371103381D8B2EB9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_5CA92D410EC1C09597BA03381D8B3B7B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_Revenues_5CA92D410EC1C09597BA03381D8B3B7B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_0C9ECD5DBD9B9120A64E03381D8B88DB" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_InterestExpense_0C9ECD5DBD9B9120A64E03381D8B88DB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConcentrationRiskNumberofCustomers" xlink:label="loc_opk_ConcentrationRiskNumberofCustomers_FC9A7DF861BAFE40991403381D8BECA2" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_opk_ConcentrationRiskNumberofCustomers_FC9A7DF861BAFE40991403381D8BECA2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_9AD570AE078088A951EE03381D8BE9C6" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_B6A6A0B90C83B5C9F96E03381D8B4D12" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_9AD570AE078088A951EE03381D8BE9C6" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/SegmentsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/ShareholdersEquity" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/ShareholdersEquityDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B0C5B8C6FA0C251BE8D8B2B5E3F43536" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2D7992A97073C333FC51B2B5E3F47B2A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B0C5B8C6FA0C251BE8D8B2B5E3F43536" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2D7992A97073C333FC51B2B5E3F47B2A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_CB9AE9B0B70A83501D6BB2B5E3F48E99" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2D7992A97073C333FC51B2B5E3F47B2A" xlink:to="loc_us-gaap_AwardTypeAxis_CB9AE9B0B70A83501D6BB2B5E3F48E99" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E360DD3EF48267EB9F99B2B5E3F46A5E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_CB9AE9B0B70A83501D6BB2B5E3F48E99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E360DD3EF48267EB9F99B2B5E3F46A5E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E360DD3EF48267EB9F99B2B5E3F46A5E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_CB9AE9B0B70A83501D6BB2B5E3F48E99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E360DD3EF48267EB9F99B2B5E3F46A5E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_8B5C2AFCE31DCB627806B2B5E3F40D5B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E360DD3EF48267EB9F99B2B5E3F46A5E" xlink:to="loc_us-gaap_WarrantMember_8B5C2AFCE31DCB627806B2B5E3F40D5B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B0C5B8C6FA0C251BE8D8B2B5E3F43536" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_74EF614F0DA3F15EA445B2B5E3F4CB72" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_74EF614F0DA3F15EA445B2B5E3F4CB72" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice_28CE0DB9C843DC2698E3B2B5E3F41156" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice_28CE0DB9C843DC2698E3B2B5E3F41156" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_9834CBD9602095472EA6B2B5E3F4E97A" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_9834CBD9602095472EA6B2B5E3F4E97A" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedWeightedAverageExercisePrice" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedWeightedAverageExercisePrice_782F7288FC036D80368CB2B5E3F407F0" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedWeightedAverageExercisePrice_782F7288FC036D80368CB2B5E3F407F0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_EE7D569F863AB3A48720B2B5E3F579C9" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_EE7D569F863AB3A48720B2B5E3F579C9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisedWeightedAverageExercisePrice" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisedWeightedAverageExercisePrice_605BE9B43D1564AF0370B2B5E3F5C21B" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisedWeightedAverageExercisePrice_605BE9B43D1564AF0370B2B5E3F5C21B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations_BDC4CBD0820F76479C9CB2B5E3F5B42E" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations_BDC4CBD0820F76479C9CB2B5E3F5B42E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpiredWeightedAverageExercisePrice" xlink:label="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpiredWeightedAverageExercisePrice_20E85F7A47B22ECEBD25B2B5E3F50DDB" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_CA07C47D1983DD491391B2B5E3F4FAE4" xlink:to="loc_opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpiredWeightedAverageExercisePrice_20E85F7A47B22ECEBD25B2B5E3F50DDB" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/ShareholdersEquityDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_3893B6B3A8EB7B69737C766FDAF96072" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_3893B6B3A8EB7B69737C766FDAF96072" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2BD67E284FBCAED0844C766FDAF999ED" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_3893B6B3A8EB7B69737C766FDAF96072" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2BD67E284FBCAED0844C766FDAF999ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2BD67E284FBCAED0844C766FDAF999ED" xlink:to="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2BD67E284FBCAED0844C766FDAF999ED" xlink:to="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_3B0A3408C672F93EEC75766FDAFE87F3" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:to="loc_us-gaap_CommonStockMember_3B0A3408C672F93EEC75766FDAFE87F3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_55529B60853AFCC763FE766FDAFFC6F8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_55529B60853AFCC763FE766FDAFFC6F8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_571159FAF8D38A3B1B06766FDAFF0D9B" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_571159FAF8D38A3B1B06766FDAFF0D9B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_26721AB9EBE18B7C1240766FDAFFFA14" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_F233DDC321D84C5280EE766FDAFE9FF3" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_26721AB9EBE18B7C1240766FDAFFFA14" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_CFB60A982B40A798BA28766FDAFF57C2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_CFB60A982B40A798BA28766FDAFF57C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_EC6EDD6CBD2EEA1C5389766FDAFF8D86" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_EC6EDD6CBD2EEA1C5389766FDAFF8D86" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_FD0C3E03BB2FBAF5D7CD766FDAFFEB0F" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_FD0C3E03BB2FBAF5D7CD766FDAFFEB0F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_CE9A61BBFFDEE656201A769226602DDE" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockSharesIssued_CE9A61BBFFDEE656201A769226602DDE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_6F93F8D6EB0A26E9B94A7694AD845222" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_6F93F8D6EB0A26E9B94A7694AD845222" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_74F512652D74A3DA26DD766FDAFF2CD8" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_74F512652D74A3DA26DD766FDAFF2CD8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ExerciseOfCommonStockWarrantsShares" xlink:label="loc_opk_ExerciseOfCommonStockWarrantsShares_4E572F441CD867EB9669766FDAFF5755" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_opk_ExerciseOfCommonStockWarrantsShares_4E572F441CD867EB9669766FDAFF5755" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NumberOfSharesSurrenderedInLieuOfCashPayments" xlink:label="loc_opk_NumberOfSharesSurrenderedInLieuOfCashPayments_6BF86E5FAEBDA8769D2E766FDAFF2550" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_opk_NumberOfSharesSurrenderedInLieuOfCashPayments_6BF86E5FAEBDA8769D2E766FDAFF2550" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ConvertiblePreferredStockSharesDesignatedMaximum" xlink:label="loc_opk_ConvertiblePreferredStockSharesDesignatedMaximum_6FAE1168C96150751218766FDAFFA404" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_opk_ConvertiblePreferredStockSharesDesignatedMaximum_6FAE1168C96150751218766FDAFFA404" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaap_PreferredStockDividendRatePercentage_E31ECFEC019B3F5748B4766FDAFFEB0A" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockDividendRatePercentage_E31ECFEC019B3F5748B4766FDAFFEB0A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_6808B3EC84CA2C172DDE766FDB00CF08" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_6808B3EC84CA2C172DDE766FDB00CF08" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockSharesConverted1" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_0D3DBA4D09210F472C39766FDB0087E8" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_0D3DBA4D09210F472C39766FDB0087E8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConversionOfStockSharesIssued1" xlink:label="loc_us-gaap_ConversionOfStockSharesIssued1_8AE9E74777BF42AE818A766FDB00C1C2" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_ConversionOfStockSharesIssued1_8AE9E74777BF42AE818A766FDB00C1C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DividendsCash" xlink:label="loc_us-gaap_DividendsCash_806D099A17A0251F234B766FDB00747D" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_DividendsCash_806D099A17A0251F234B766FDB00747D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockPerShareAmountsOfPreferredDividendsInArrears" xlink:label="loc_us-gaap_PreferredStockPerShareAmountsOfPreferredDividendsInArrears_8673EC12D560061729D0766FDAFFE457" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockPerShareAmountsOfPreferredDividendsInArrears_8673EC12D560061729D0766FDAFFE457" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockAmountOfPreferredDividendsInArrears" xlink:label="loc_us-gaap_PreferredStockAmountOfPreferredDividendsInArrears_F42675AD4268F5FB27E876A13A3AD3A8" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_D080A0B3BE6E3C0C049B766FDAFF7B4B" xlink:to="loc_us-gaap_PreferredStockAmountOfPreferredDividendsInArrears_F42675AD4268F5FB27E876A13A3AD3A8" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/ShareholdersEquityTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/StrategicAlliances" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/StrategicAlliancesStrategicAlliancesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_D7582AA7518746F55B31CBBD14D2F9B4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_D7582AA7518746F55B31CBBD14D2F9B4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_35F488DB19F6340EFA82CBBD14D70849_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D7582AA7518746F55B31CBBD14D2F9B4" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_35F488DB19F6340EFA82CBBD14D70849_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_35F488DB19F6340EFA82CBBD14D70849" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D7582AA7518746F55B31CBBD14D2F9B4" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_35F488DB19F6340EFA82CBBD14D70849" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_C4FA7535414F6B0CAF2BCBBD14D7E4BF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_35F488DB19F6340EFA82CBBD14D70849" xlink:to="loc_us-gaap_SubsequentEventMember_C4FA7535414F6B0CAF2BCBBD14D7E4BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A7DA1B6D12902956AF70CBBD14D79FAD" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A7DA1B6D12902956AF70CBBD14D79FAD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_6D6E094263AA02994756CBBD14D819D0_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A7DA1B6D12902956AF70CBBD14D79FAD" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_6D6E094263AA02994756CBBD14D819D0_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_6D6E094263AA02994756CBBD14D819D0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A7DA1B6D12902956AF70CBBD14D79FAD" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_6D6E094263AA02994756CBBD14D819D0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RxiPharmaceuticalsCorporationMember" xlink:label="loc_opk_RxiPharmaceuticalsCorporationMember_C01D86B88D3CDD26E586CBBD14D8E788" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_6D6E094263AA02994756CBBD14D819D0" xlink:to="loc_opk_RxiPharmaceuticalsCorporationMember_C01D86B88D3CDD26E586CBBD14D8E788" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_77124DD6C04CC224B892CBBD14D83202" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:to="loc_us-gaap_CounterpartyNameAxis_77124DD6C04CC224B892CBBD14D83202" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_77124DD6C04CC224B892CBBD14D83202" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_77124DD6C04CC224B892CBBD14D83202" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PfizerInc.Member" xlink:label="loc_opk_PfizerInc.Member_D40C6301FDB4785D8B8BCBBD14D83E02" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE" xlink:to="loc_opk_PfizerInc.Member_D40C6301FDB4785D8B8BCBBD14D83E02" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_9F9AABBC89620BC11A11CBBD14D81A4C" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE" xlink:to="loc_opk_TesaroMember_9F9AABBC89620BC11A11CBBD14D81A4C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_MerckMember" xlink:label="loc_opk_MerckMember_1997A477FF5245C38977CBBD14D8ACE6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_17DD7DE19728A3053CF1CBBD14D8EADE" xlink:to="loc_opk_MerckMember_1997A477FF5245C38977CBBD14D8ACE6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_77600EC0075B4672E51DCBBD14D8147E" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_77600EC0075B4672E51DCBBD14D8147E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_0D5ED53CA87C2B3D9739CBBD14D8B252_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_77600EC0075B4672E51DCBBD14D8147E" xlink:to="loc_us-gaap_RelatedPartyDomain_0D5ED53CA87C2B3D9739CBBD14D8B252_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_0D5ED53CA87C2B3D9739CBBD14D8B252" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_77600EC0075B4672E51DCBBD14D8147E" xlink:to="loc_us-gaap_RelatedPartyDomain_0D5ED53CA87C2B3D9739CBBD14D8B252" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_A8D514CA37F1CD21EAF3CBBD14D81336" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_0D5ED53CA87C2B3D9739CBBD14D8B252" xlink:to="loc_opk_TesaroMember_A8D514CA37F1CD21EAF3CBBD14D81336" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_08A8C438C07330C26E8DCBBD14D8C327" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4E346C5FD0BE2B88750CCBBD14D2BFF9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_08A8C438C07330C26E8DCBBD14D8C327" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_08A8C438C07330C26E8DCBBD14D8C327" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_08A8C438C07330C26E8DCBBD14D8C327" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementProductAgreementMember" xlink:label="loc_us-gaap_CollaborativeArrangementProductAgreementMember_ED9F4B8F159D1CA728FCCBBD14D83772" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA" xlink:to="loc_us-gaap_CollaborativeArrangementProductAgreementMember_ED9F4B8F159D1CA728FCCBBD14D83772" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_F6A87F37261DEFEA8E1ECBBD14D9D82F" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9BE79294DB8C62276BE9CBBD14D8CFCA" xlink:to="loc_us-gaap_CollaborativeArrangementMember_F6A87F37261DEFEA8E1ECBBD14D9D82F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementUpfrontPayment" xlink:label="loc_opk_CollaborativeArrangementUpfrontPayment_B002FA1EA5FCCD49163DCBBD14DEF46F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_CollaborativeArrangementUpfrontPayment_B002FA1EA5FCCD49163DCBBD14DEF46F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementMaximumMilestonePayments" xlink:label="loc_opk_CollaborativeArrangementMaximumMilestonePayments_BD9F07D942DD939074C1CBBD14DE92F9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_CollaborativeArrangementMaximumMilestonePayments_BD9F07D942DD939074C1CBBD14DE92F9" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PaymentsUnderLicenseAgreements" xlink:label="loc_opk_PaymentsUnderLicenseAgreements_F143E0E61BD137D89934CBBD14DE0E30" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_PaymentsUnderLicenseAgreements_F143E0E61BD137D89934CBBD14DE0E30" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LicenseAndCollaborationAgreementsProceedsAsUpFrontPayment" xlink:label="loc_opk_LicenseAndCollaborationAgreementsProceedsAsUpFrontPayment_D7B5112E43BBCD37DAE0CBBD14DE1550" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_LicenseAndCollaborationAgreementsProceedsAsUpFrontPayment_D7B5112E43BBCD37DAE0CBBD14DE1550" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementMilestonePaymentReceived" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentReceived_7D9A1A760318E878DF3DCBBD14DE1703" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_CollaborativeArrangementMilestonePaymentReceived_7D9A1A760318E878DF3DCBBD14DE1703" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementMilestonePaymentPaid" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentPaid_17CFAA8ABA176DA72DE4CBBD14DE62AE" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_CollaborativeArrangementMilestonePaymentPaid_17CFAA8ABA176DA72DE4CBBD14DE62AE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_C4AA423368524DFA9F46CBBD14FFE8AA" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_C4AA423368524DFA9F46CBBD14FFE8AA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeAgreementAdditionalMilestonePayment" xlink:label="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_45718804D984BEF26F61CBBD14DE2AEA" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_45718804D984BEF26F61CBBD14DE2AEA" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromSaleOfIntellectualProperty" xlink:label="loc_opk_RevenueFromSaleOfIntellectualProperty_F441DF0066649D5ADB04CBBD14DEA3A1" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_RevenueFromSaleOfIntellectualProperty_F441DF0066649D5ADB04CBBD14DEA3A1" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" xlink:label="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_63F596CE7E6CF0D80CA8CBBD14DF6EB3" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_5BC71F9E5C08C8545185CBBD14D9317D" xlink:to="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_63F596CE7E6CF0D80CA8CBBD14DF6EB3" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/SubsequentEvents" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SubsequentEventsSubsequentEventsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_56779A09AAAD5B8CAE75CBBD3168750C" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_02EAB8F6B0C3ACBEAA8CCBBD3167981C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_56779A09AAAD5B8CAE75CBBD3168750C" xlink:to="loc_us-gaap_SubsequentEventTable_02EAB8F6B0C3ACBEAA8CCBBD3167981C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_B6BCB69599D7B2445CA1CBBD31678759" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_02EAB8F6B0C3ACBEAA8CCBBD3167981C" xlink:to="loc_us-gaap_CounterpartyNameAxis_B6BCB69599D7B2445CA1CBBD31678759" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_6819A2E3DEE63E5646DACBBD316715B8_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_B6BCB69599D7B2445CA1CBBD31678759" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_6819A2E3DEE63E5646DACBBD316715B8_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_6819A2E3DEE63E5646DACBBD316715B8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_B6BCB69599D7B2445CA1CBBD31678759" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_6819A2E3DEE63E5646DACBBD316715B8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PfizerInc.Member" xlink:label="loc_opk_PfizerInc.Member_3ED3FD48CEA12223E3CCCBBD3167FAE2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_6819A2E3DEE63E5646DACBBD316715B8" xlink:to="loc_opk_PfizerInc.Member_3ED3FD48CEA12223E3CCCBBD3167FAE2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_174E90BD6B40453162A6CBBD316743D6" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_02EAB8F6B0C3ACBEAA8CCBBD3167981C" xlink:to="loc_us-gaap_TypeOfArrangementAxis_174E90BD6B40453162A6CBBD316743D6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_94FDCB24BD63610AD7E9CBBD31684D2B_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_174E90BD6B40453162A6CBBD316743D6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_94FDCB24BD63610AD7E9CBBD31684D2B_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_94FDCB24BD63610AD7E9CBBD31684D2B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_174E90BD6B40453162A6CBBD316743D6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_94FDCB24BD63610AD7E9CBBD31684D2B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementProductAgreementMember" xlink:label="loc_us-gaap_CollaborativeArrangementProductAgreementMember_0F9A1C78B459E6BBC457CBBD31681BA0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_94FDCB24BD63610AD7E9CBBD31684D2B" xlink:to="loc_us-gaap_CollaborativeArrangementProductAgreementMember_0F9A1C78B459E6BBC457CBBD31681BA0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_4CBA98A68686C157C2C3CBBD31687B05" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_02EAB8F6B0C3ACBEAA8CCBBD3167981C" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_4CBA98A68686C157C2C3CBBD31687B05" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_A70677E899B718F46750CBBD3168526D_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4CBA98A68686C157C2C3CBBD31687B05" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_A70677E899B718F46750CBBD3168526D_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_A70677E899B718F46750CBBD3168526D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4CBA98A68686C157C2C3CBBD31687B05" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_A70677E899B718F46750CBBD3168526D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_6BF8B88D7DE54F8CD276CBBD3168CE8F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_A70677E899B718F46750CBBD3168526D" xlink:to="loc_us-gaap_SubsequentEventMember_6BF8B88D7DE54F8CD276CBBD3168CE8F" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementObligationPayable" xlink:label="loc_opk_CollaborativeArrangementObligationPayable_2FE757D3481098E14579CBBD31682188" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_56779A09AAAD5B8CAE75CBBD3168750C" xlink:to="loc_opk_CollaborativeArrangementObligationPayable_2FE757D3481098E14579CBBD31682188" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended"/>
<definitionLink xlink:role="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
<loc xlink:href="opk-20141231.xsd#opk_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:type="locator"/>
<loc xlink:href="opk-20141231.xsd#opk_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_CD158908D60DD2124BEDC79EE8B17614" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_CounterpartyNameAxis_CD158908D60DD2124BEDC79EE8B17614" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_989D9BA65CE7F132EE59C79EE8B16D90_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_CD158908D60DD2124BEDC79EE8B17614" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_989D9BA65CE7F132EE59C79EE8B16D90_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_989D9BA65CE7F132EE59C79EE8B16D90" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_CD158908D60DD2124BEDC79EE8B17614" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_989D9BA65CE7F132EE59C79EE8B16D90" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_FF521744D3715C38E1A4C79EE8B1E6C1" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_989D9BA65CE7F132EE59C79EE8B16D90" xlink:to="loc_opk_TesaroMember_FF521744D3715C38E1A4C79EE8B1E6C1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_4E510575C06592F37E93C79EE8B1C1A2" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_TypeOfArrangementAxis_4E510575C06592F37E93C79EE8B1C1A2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8C140F86C70AF8C98392C79EE8B1C1BB_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4E510575C06592F37E93C79EE8B1C1A2" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8C140F86C70AF8C98392C79EE8B1C1BB_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8C140F86C70AF8C98392C79EE8B1C1BB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4E510575C06592F37E93C79EE8B1C1A2" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8C140F86C70AF8C98392C79EE8B1C1BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_86D459B809768ED1F2C3C79EE8B19BBA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8C140F86C70AF8C98392C79EE8B1C1BB" xlink:to="loc_us-gaap_CollaborativeArrangementMember_86D459B809768ED1F2C3C79EE8B19BBA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A676E74072B84551EA48C79EE8B16652" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A676E74072B84551EA48C79EE8B16652" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A676E74072B84551EA48C79EE8B16652" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_A676E74072B84551EA48C79EE8B16652" xlink:to="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_3AC3961C606C6CDBAAEBC79EE8B145FB" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C" xlink:to="loc_opk_TesaroMember_3AC3961C606C6CDBAAEBC79EE8B145FB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RxiPharmaceuticalsCorporationMember" xlink:label="loc_opk_RxiPharmaceuticalsCorporationMember_675EAA14F293822E4A5EC79EE8B11D54" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C" xlink:to="loc_opk_RxiPharmaceuticalsCorporationMember_675EAA14F293822E4A5EC79EE8B11D54" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_8DD4CE88AFDBD4C49F43C79EE8B159BE" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_2AA867F4D9057240DC6BC79EE8B1067C" xlink:to="loc_opk_PharmsynthezMember_8DD4CE88AFDBD4C49F43C79EE8B159BE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3069CFDDB0A997F6E238C79EE8B1CD10" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3069CFDDB0A997F6E238C79EE8B1CD10" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3069CFDDB0A997F6E238C79EE8B1CD10" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3069CFDDB0A997F6E238C79EE8B1CD10" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ComputerSoftwareIntangibleAssetMember" xlink:label="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_B743A64DC0E1F9D398B4C79EE8B2BC4E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:to="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_B743A64DC0E1F9D398B4C79EE8B2BC4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_A4FE24A1AB18F0C8A819C79EE8B25E32" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_A4FE24A1AB18F0C8A819C79EE8B25E32" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_908D8AA35C6AAF5BCEADC79EE8B2E6E3" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_908D8AA35C6AAF5BCEADC79EE8B2E6E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LandBuildingsAndImprovementsMember" xlink:label="loc_us-gaap_LandBuildingsAndImprovementsMember_421CD8CEDA2C2D712678C79EE8B24A35" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_CDEBD2F948A57A5B6EBAC79EE8B13A5E" xlink:to="loc_us-gaap_LandBuildingsAndImprovementsMember_421CD8CEDA2C2D712678C79EE8B24A35" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_E700A2DA1CB47FF15003C79EE8B20AAD" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_E700A2DA1CB47FF15003C79EE8B20AAD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4DFFB8C3DCC3F9208DAFC79EE8B291DF_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_E700A2DA1CB47FF15003C79EE8B20AAD" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4DFFB8C3DCC3F9208DAFC79EE8B291DF_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4DFFB8C3DCC3F9208DAFC79EE8B291DF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_E700A2DA1CB47FF15003C79EE8B20AAD" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4DFFB8C3DCC3F9208DAFC79EE8B291DF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_F67AA399CA0C96F4BA4DC79EE8B2004D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4DFFB8C3DCC3F9208DAFC79EE8B291DF" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_F67AA399CA0C96F4BA4DC79EE8B2004D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_50A0C87CC55C74D029D0C79EE8B2E6F2" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_DebtInstrumentAxis_50A0C87CC55C74D029D0C79EE8B2E6F2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F3935382BAAEDF60D66DC79EE8B2B8B8_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_50A0C87CC55C74D029D0C79EE8B2E6F2" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F3935382BAAEDF60D66DC79EE8B2B8B8_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F3935382BAAEDF60D66DC79EE8B2B8B8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_50A0C87CC55C74D029D0C79EE8B2E6F2" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F3935382BAAEDF60D66DC79EE8B2B8B8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_AB1A7283C00CE7D4869FC79EE8B232C5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F3935382BAAEDF60D66DC79EE8B2B8B8" xlink:to="loc_opk_NotesDueFebruary12033Member_AB1A7283C00CE7D4869FC79EE8B232C5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_75B5ED7729CDA9ECEE9BC79EE8B2CB20" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_75B5ED7729CDA9ECEE9BC79EE8B2CB20" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_75B5ED7729CDA9ECEE9BC79EE8B2CB20" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_75B5ED7729CDA9ECEE9BC79EE8B2CB20" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherExpenseMember" xlink:label="loc_us-gaap_OtherExpenseMember_3E33DB9BBB59A9F90DE1C79EE8B22895" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC" xlink:to="loc_us-gaap_OtherExpenseMember_3E33DB9BBB59A9F90DE1C79EE8B22895" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredDerivativeGainLossMember" xlink:label="loc_us-gaap_DeferredDerivativeGainLossMember_7FCDF86E9DD7C475F2B2C79EE8B22E06" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_FCEB44723A551F1620F3C79EE8B2F2BC" xlink:to="loc_us-gaap_DeferredDerivativeGainLossMember_7FCDF86E9DD7C475F2B2C79EE8B22E06" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_14FD085629C901CB39B3C79EE8B2A943" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_StatementScenarioAxis_14FD085629C901CB39B3C79EE8B2A943" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_862B109C1650FC8E8AF4C79EE8B21C1F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_14FD085629C901CB39B3C79EE8B2A943" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_862B109C1650FC8E8AF4C79EE8B21C1F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_862B109C1650FC8E8AF4C79EE8B21C1F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_14FD085629C901CB39B3C79EE8B2A943" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_862B109C1650FC8E8AF4C79EE8B21C1F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestatementAdjustmentMember" xlink:label="loc_us-gaap_RestatementAdjustmentMember_4C04F0FD7B05CEEE191FC79EE8B3D780" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_862B109C1650FC8E8AF4C79EE8B21C1F" xlink:to="loc_us-gaap_RestatementAdjustmentMember_4C04F0FD7B05CEEE191FC79EE8B3D780" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_E668A42821ED73750F83C79EE8B3202A" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_RangeAxis_E668A42821ED73750F83C79EE8B3202A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_E668A42821ED73750F83C79EE8B3202A" xlink:to="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_E668A42821ED73750F83C79EE8B3202A" xlink:to="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_E1ABB67E6A6B190D4161C79EE8B3FEAD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980" xlink:to="loc_us-gaap_MinimumMember_E1ABB67E6A6B190D4161C79EE8B3FEAD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_DD4E0324B3CE592D02E6C79EE8B3D6C0" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_6C4D52302930E90664A6C79EE8B30980" xlink:to="loc_us-gaap_MaximumMember_DD4E0324B3CE592D02E6C79EE8B3D6C0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_21DC87697C7D84DC049CC79EE8B38DC5" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_dei_LegalEntityAxis_21DC87697C7D84DC049CC79EE8B38DC5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_1CBF6F85C3F249BB9005C79EE8B3F0D2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_21DC87697C7D84DC049CC79EE8B38DC5" xlink:to="loc_dei_EntityDomain_1CBF6F85C3F249BB9005C79EE8B3F0D2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_1CBF6F85C3F249BB9005C79EE8B3F0D2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_21DC87697C7D84DC049CC79EE8B38DC5" xlink:to="loc_dei_EntityDomain_1CBF6F85C3F249BB9005C79EE8B3F0D2" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_NeovascMember" xlink:label="loc_opk_NeovascMember_CE1BD3D835C5736B3863C79EE8B35372" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_1CBF6F85C3F249BB9005C79EE8B3F0D2" xlink:to="loc_opk_NeovascMember_CE1BD3D835C5736B3863C79EE8B35372" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_A71D9E3AA451EFCCD991C79EE8B3C79F" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_CD46C3DA5F3583EE1F6EC79EE8B06D61" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_A71D9E3AA451EFCCD991C79EE8B3C79F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_A71D9E3AA451EFCCD991C79EE8B3C79F" xlink:to="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_A71D9E3AA451EFCCD991C79EE8B3C79F" xlink:to="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_C925A710DD8269A7861CC79EE8B35AD8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543" xlink:to="loc_opk_PharmaceuticalMember_C925A710DD8269A7861CC79EE8B35AD8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_0F175A117AC743854CF7C79EE8B31731" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_5F4EEE77AF7958E5E5E6C79EE8B3B543" xlink:to="loc_opk_DiagnosticsMember_0F175A117AC743854CF7C79EE8B31731" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2192853A536FF2F47208C79EE8B3274F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2192853A536FF2F47208C79EE8B3274F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_9DB88C52DBF3638EB9BEC79EE8B38BB1" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_9DB88C52DBF3638EB9BEC79EE8B38BB1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_DFA423AFF59A74CF11B4C79EE8B3FC24" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_DFA423AFF59A74CF11B4C79EE8B3FC24" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmbeddedDerivativeLossOnEmbeddedDerivative" xlink:label="loc_us-gaap_EmbeddedDerivativeLossOnEmbeddedDerivative_2913F87204E7258672DCC79EE8B35602" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_EmbeddedDerivativeLossOnEmbeddedDerivative_2913F87204E7258672DCC79EE8B35602" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_EE5445856DB980E9A8E4C79EE8B3CAC0" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_EE5445856DB980E9A8E4C79EE8B3CAC0" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" xlink:label="loc_opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent_F5B6EE4432014A88C10EC79EE8B306DE" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent_F5B6EE4432014A88C10EC79EE8B306DE" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" xlink:label="loc_opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities_01E9DB8C966AD2C5D79AC79EE8B4A1F4" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities_01E9DB8C966AD2C5D79AC79EE8B4A1F4" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShortTermInvestmentsMaturitiesPeriodMinimum" xlink:label="loc_opk_ShortTermInvestmentsMaturitiesPeriodMinimum_812FFE6D42B5EB275136C79EE8B4D2EB" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_ShortTermInvestmentsMaturitiesPeriodMinimum_812FFE6D42B5EB275136C79EE8B4D2EB" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_1E26498774F4FD6E7068C79EE8B439D3" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_1E26498774F4FD6E7068C79EE8B439D3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_AA1D7C539DF5FF104D26C79EE8B47EBB" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_AA1D7C539DF5FF104D26C79EE8B47EBB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_551755D57CA39245A80AC79EE8B429E3" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_551755D57CA39245A80AC79EE8B429E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_B39FD62FE82BC97E9613C79EE8B4EDC5" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_B39FD62FE82BC97E9613C79EE8B4EDC5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_35A007BBA792BB1745CFC79EE8B4DAAD" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_35A007BBA792BB1745CFC79EE8B4DAAD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_B9B6A49674A2A192C485C79EE8B43D56" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_B9B6A49674A2A192C485C79EE8B43D56" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_636A76F2C46E57FD426FC79EE8B4FB53" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_636A76F2C46E57FD426FC79EE8B4FB53" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_840B997D7C5218F8897BC79EE8B4A54D" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_840B997D7C5218F8897BC79EE8B4A54D" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_ShortTermInvestmentsMaturitiesPeriodMaximum" xlink:label="loc_opk_ShortTermInvestmentsMaturitiesPeriodMaximum_B520B2313032726739ECC79EE8B4B2E8" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_ShortTermInvestmentsMaturitiesPeriodMaximum_B520B2313032726739ECC79EE8B4B2E8" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_LongTermInvestmentsMaturitiesPeriodMinimum" xlink:label="loc_opk_LongTermInvestmentsMaturitiesPeriodMinimum_EB3ED849855ED7A682ACC79EE8B43E7C" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_LongTermInvestmentsMaturitiesPeriodMinimum_EB3ED849855ED7A682ACC79EE8B43E7C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_854815EBCBDE278110CDC79EE8B4487A" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_854815EBCBDE278110CDC79EE8B4487A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_1E9C1C987274E3143756C79EE8B446F2" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_Depreciation_1E9C1C987274E3143756C79EE8B446F2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_80853B531D17DDAD5F6BC79EE8B44B29" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_SalesRevenueServicesNet_80853B531D17DDAD5F6BC79EE8B44B29" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromTransferOfIntellectualProperty" xlink:label="loc_opk_RevenueFromTransferOfIntellectualProperty_3665E988C77378EC9B63C79EE8B4AD4E" xlink:type="locator"/>
<definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_RevenueFromTransferOfIntellectualProperty_3665E988C77378EC9B63C79EE8B4AD4E" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_CollaborativeArrangementMilestonePaymentReceived" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentReceived_BC42D30BB1695F9707C0C79EE8B4DC95" xlink:type="locator"/>
<definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_CollaborativeArrangementMilestonePaymentReceived_BC42D30BB1695F9707C0C79EE8B4DC95" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LicenseAndServicesRevenue" xlink:label="loc_us-gaap_LicenseAndServicesRevenue_74C9E2C9CE517669E42CC79EE8B4CA5E" xlink:type="locator"/>
<definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_LicenseAndServicesRevenue_74C9E2C9CE517669E42CC79EE8B4CA5E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_5CA1A8EAEDCD89A43D1CC79EE8B42C24" xlink:type="locator"/>
<definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_DeferredRevenue_5CA1A8EAEDCD89A43D1CC79EE8B42C24" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_4939F315960D44105C9FC79EE8B45D3A" xlink:type="locator"/>
<definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_4939F315960D44105C9FC79EE8B45D3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_0901022B0DFAF7C4A70DC79EE8B42F10" xlink:type="locator"/>
<definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_ShareBasedCompensation_0901022B0DFAF7C4A70DC79EE8B42F10" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_5331C569516DAC888129C79EE8B4A34B" xlink:type="locator"/>
<definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_NumberOfReportableSegments_5331C569516DAC888129C79EE8B4A34B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NumberOfOperatingSegments" xlink:label="loc_us-gaap_NumberOfOperatingSegments_0F73324067044690F050C79EE8B54AC6" xlink:type="locator"/>
<definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_us-gaap_NumberOfOperatingSegments_0F73324067044690F050C79EE8B54AC6" xlink:type="arc"/>
<loc xlink:href="opk-20141231.xsd#opk_RevenueFromSaleOfIntellectualProperty" xlink:label="loc_opk_RevenueFromSaleOfIntellectualProperty_920BEFA165B68C39BFD6C79EE8B5069D" xlink:type="locator"/>
<definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_E02D186C8F4F5AAD09C7C79EE8B304CF" xlink:to="loc_opk_RevenueFromSaleOfIntellectualProperty_920BEFA165B68C39BFD6C79EE8B5069D" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
</linkbase>

3 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
 7/13/15  SEC                               UPLOAD9/18/17    1:12K  Opko Health, Inc.
 6/29/15  SEC                               UPLOAD9/18/17    1:267K Opko Health, Inc.
↑Top
Filing Submission 0000944809-15-000003   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Sun., May 12, 4:51:05.2pm ET