SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-Q’ for 9/30/15 – ‘EX-101.LAB’

On:  Monday, 11/9/15, at 5:13pm ET   ·   For:  9/30/15   ·   Accession #:  944809-15-14   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 8/5/15 for 6/30/15   ·   Next:  ‘10-Q’ on 5/9/16 for 3/31/16   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

11/09/15  Opko Health, Inc.                 10-Q        9/30/15   80:11M

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    815K 
 2: EX-23.1     Consent of Experts or Counsel                       HTML     28K 
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     30K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     30K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     24K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     24K 
53: R1          Document and Entity Information                     HTML     42K 
41: R2          Condensed Consolidated Balance Sheets (Unaudited)   HTML    112K 
51: R3          Condensed Consolidated Balance Sheets (Unaudited)   HTML     38K 
                (Parenthetical)                                                  
55: R4          Condensed Consolidated Statements of Operations     HTML    109K 
                (Unaudited)                                                      
74: R5          Condensed Consolidated Statements of Comprehensive  HTML     51K 
                Income (Loss) (Unaudited)                                        
43: R6          Condensed Consolidated Statements of Cash Flows     HTML    185K 
                (Unaudited)                                                      
50: R7          Condensed Consolidated Statements of Cash Flows     HTML     26K 
                (Unaudited) (Parenthetical)                                      
37: R8          Business and Organization                           HTML     34K 
28: R9          Summary of Significant Accounting Policies          HTML     74K 
75: R10         Earnings (Loss) Per Share                           HTML     80K 
57: R11         Composition of Certain Financial Statement          HTML    140K 
                Captions                                                         
56: R12         Acquisitions, Investments, and Licenses             HTML    147K 
62: R13         Debt                                                HTML    126K 
63: R14         Accumulated Other Comprehensive Income (Loss)       HTML     44K 
60: R15         Fair Value Measurements                             HTML    177K 
64: R16         Derivative Contracts                                HTML    100K 
52: R17         Related Party Transactions                          HTML     39K 
54: R18         Commitments and Contingencies                       HTML     37K 
59: R19         Strategic Alliances                                 HTML     45K 
80: R20         Segments                                            HTML    164K 
69: R21         Subsequent Events                                   HTML     35K 
47: R22         Summary of Significant Accounting Policies          HTML    136K 
                (Policies)                                                       
58: R23         Earnings (Loss) Per Share (Tables)                  HTML     72K 
49: R24         Composition of Certain Financial Statement          HTML    141K 
                Captions (Tables)                                                
21: R25         Acquisitions, Investments, and Licenses (Tables)    HTML    126K 
71: R26         Debt (Tables)                                       HTML    102K 
77: R27         Accumulated Other Comprehensive Income (Loss)       HTML     40K 
                (Tables)                                                         
32: R28         Fair Value Measurements (Tables)                    HTML    174K 
31: R29         Derivative Contracts (Tables)                       HTML    100K 
35: R30         Segments (Tables)                                   HTML    155K 
36: R31         Business and Organization (Details)                 HTML     44K 
38: R32         Summary of Significant Accounting Policies          HTML    103K 
                (Details)                                                        
19: R33         Earnings (Loss) Per Share (Details)                 HTML     62K 
67: R34         Earnings (Loss) Per Share - Narrative (Details)     HTML     36K 
45: R35         Composition of Certain Financial Statement          HTML    155K 
                Captions (Details)                                               
48: R36         Composition of Certain Financial Statement          HTML     70K 
                Captions - Changes in Goodwill (Details)                         
24: R37         Acquisitions, Investments, and Licenses -           HTML     98K 
                Acquisition Narrative (Details)                                  
79: R38         Acquisitions, Investments, and Licenses - Schedule  HTML    115K 
                of Purchase Price Allocation (Details)                           
13: R39         Acquisitions, Investments, and Licenses - Schedule  HTML     35K 
                of Pro Forma (Details)                                           
39: R40         Acquisitions, Investments, and Licenses - Summary   HTML     38K 
                of Investments (Details)                                         
73: R41         Acquisitions, Investments, and Licenses - Equity    HTML     56K 
                Method Investments Narrative (Details)                           
23: R42         Acquisitions, Investments, and Licenses -           HTML     51K 
                Available for Sale Investments, Sale of                          
                Investments and Warrants and Options Narrative                   
                (Details)                                                        
30: R43         Acquisitions, Investments, and Licenses - Variable  HTML     91K 
                Interest Entities Narrative (Details)                            
34: R44         Acquisitions, Investments, and Licenses - Schedule  HTML     83K 
                of Consolidated Assets and Non-Recourse                          
                Liabilities (Details)                                            
42: R45         Debt - Narrative (Details)                          HTML    179K 
18: R46         Debt - Notes (Details)                              HTML     53K 
27: R47         Debt - Inputs Used In Lattice Model (Details)       HTML     44K 
15: R48         Debt - Fair Value Of Embedded Derivatives           HTML     30K 
                (Details)                                                        
72: R49         Debt - Lines Of Credit (Details)                    HTML     59K 
22: R50         Debt - Mortgage Notes And Other Debt (Details)      HTML     35K 
68: R51         Accumulated Other Comprehensive Income (Loss)       HTML     46K 
                (Details)                                                        
25: R52         Fair Value Measurements - Summary Of Investments    HTML     43K 
                (Details)                                                        
40: R53         Fair Value Measurements - Assets And Liabilities    HTML     68K 
                Measured At Fair Value (Details)                                 
14: R54         Fair Value Measurements - Notes (Details)           HTML     30K 
17: R55         Fair Value Measurements - Level 3 Reconciliation    HTML     39K 
                (Details)                                                        
33: R56         Fair Value Measurements - Narrative (Details)       HTML     45K 
20: R57         Derivative Contracts - Balance Sheet Component      HTML     43K 
                (Details)                                                        
76: R58         Derivative Contracts - Derivative Gains (Losses)    HTML     34K 
                (Details)                                                        
44: R59         Derivative Contracts - Outstanding Forward          HTML     62K 
                Contracts (Details)                                              
61: R60         Related Party Transactions (Details)                HTML    158K 
26: R61         Commitments and Contingencies (Details)             HTML     35K 
29: R62         Strategic Alliances (Details)                       HTML    100K 
66: R63         Segments - Narrative (Details)                      HTML     50K 
65: R64         Segments (Details)                                  HTML     86K 
46: R65         Subsequent Events (Details)                         HTML     86K 
78: XML         IDEA XML File -- Filing Summary                      XML    142K 
16: EXCEL       IDEA Workbook of Financial Reports                  XLSX    121K 
 7: EX-101.INS  XBRL Instance -- opk-20150930                        XML   3.53M 
 9: EX-101.CAL  XBRL Calculations -- opk-20150930_cal                XML    237K 
10: EX-101.DEF  XBRL Definitions -- opk-20150930_def                 XML   1.20M 
11: EX-101.LAB  XBRL Labels -- opk-20150930_lab                      XML   2.15M 
12: EX-101.PRE  XBRL Presentations -- opk-20150930_pre               XML   1.43M 
 8: EX-101.SCH  XBRL Schema -- opk-20150930                          XSD    206K 
70: ZIP         XBRL Zipped Folder -- 0000944809-15-000014-xbrl      Zip    354K

‘EX-101.LAB’   —   XBRL Labels — opk-20150930_lab

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple"/>
<link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple"/>
<link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
<link:label id="lab_us-gaap_BusinessCombinationsAbstract_C7D0D4CAF72D5511C4E4AF42724E5B7B_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsAbstract_C7D0D4CAF72D5511C4E4AF42724E5B7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_C7D0D4CAF72D5511C4E4AF42724E5B7B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_C7D0D4CAF72D5511C4E4AF42724E5B7B" xlink:to="lab_us-gaap_BusinessCombinationsAbstract_C7D0D4CAF72D5511C4E4AF42724E5B7B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0ABE8AE89B25E52504CCAF42724EF757" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A_terseLabel_en-US" xlink:label="lab_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Axis] </link:label>
<link:label id="lab_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A_label_en-US" xlink:label="lab_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Axis] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentAxis" xlink:label="loc_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A" xlink:to="lab_invest_InvestmentAxis_3336809F39839DD2AE73AF42724EAC5A" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8_terseLabel_en-US" xlink:label="lab_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Domain] </link:label>
<link:label id="lab_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8_label_en-US" xlink:label="lab_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Domain] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentDomain" xlink:label="loc_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8" xlink:to="lab_invest_InvestmentDomain_5C8163EFC6F600EB3BD3AF42724E0EF8" xlink:type="arc"/>
<link:label id="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez </link:label>
<link:label id="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703_label_en-US" xlink:label="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:label id="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703_documentation_en-US" xlink:label="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:to="lab_opk_PharmsynthezMember_479AB4408F528C152B8CAF42724EC703" xlink:type="arc"/>
<link:label id="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05_terseLabel_en-US" xlink:label="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cocrystal </link:label>
<link:label id="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05_label_en-US" xlink:label="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cocrystal [Member] </link:label>
<link:label id="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05_documentation_en-US" xlink:label="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cocrystal. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CocrystalMember" xlink:label="loc_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:to="lab_opk_CocrystalMember_20BE70855E464C97DC31AF42724EEE05" xlink:type="arc"/>
<link:label id="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546_terseLabel_en-US" xlink:label="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sevion </link:label>
<link:label id="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546_label_en-US" xlink:label="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sevion [Member] </link:label>
<link:label id="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546_documentation_en-US" xlink:label="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Sevion [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SevionMember" xlink:label="loc_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:to="lab_opk_SevionMember_74A7FF148979C1E142B7AF42724E6546" xlink:type="arc"/>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D_terseLabel_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. </link:label>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D_label_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. [Member] </link:label>
<link:label id="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D_documentation_en-US" xlink:label="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Non-Invasive Monitoring Systems, Inc. [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_NonInvasiveMonitoringSystemsInc.Member" xlink:label="loc_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:to="lab_opk_NonInvasiveMonitoringSystemsInc.Member_09D365ECA58D1ABDE606AF42724F346D" xlink:type="arc"/>
<link:label id="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337_terseLabel_en-US" xlink:label="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Neovasc </link:label>
<link:label id="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337_label_en-US" xlink:label="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Neovasc [Member] </link:label>
<link:label id="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337_documentation_en-US" xlink:label="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Neovasc [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_NeovascMember" xlink:label="loc_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:to="lab_opk_NeovascMember_77A20E60D61BF04449E3AF42724F6337" xlink:type="arc"/>
<link:label id="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D_terseLabel_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> STI </link:label>
<link:label id="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D_label_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Levon Resources Ltd [Member] </link:label>
<link:label id="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D_documentation_en-US" xlink:label="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Levon Resources Ltd [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LevonResourcesLtdMember" xlink:label="loc_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:to="lab_opk_LevonResourcesLtdMember_BC8A32DC39FB64282BDCAF42724FC46D" xlink:type="arc"/>
<link:label id="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9_terseLabel_en-US" xlink:label="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc </link:label>
<link:label id="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9_label_en-US" xlink:label="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc [Member] </link:label>
<link:label id="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9_documentation_en-US" xlink:label="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_InCellDxIncMember" xlink:label="loc_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:to="lab_opk_InCellDxIncMember_C57584D3286D96042A7CAF42724F41C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Line Items] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Equity Method Investments [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E4A92DA8E25B1EF4EEF9AF42724FCF44" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_19C09FEA79D4D0019B6CAF42724FAF92" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total assets of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_0B5883233C10FF596935AF42724F40B3" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256_negatedLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities_E4A51B80410B81ED911FAF42724F3256" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Net losses of equity method investees </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Summarized Financial Information, Net Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708" xlink:to="lab_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_5F4FB84E448FAD17F78DAF42724F2708" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Market value </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Quoted Market Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentQuotedMarketValue" xlink:label="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716" xlink:to="lab_us-gaap_EquityMethodInvestmentQuotedMarketValue_CA170F0B135137349647AF42724FA716" xlink:type="arc"/>
<link:label id="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12_label_en-US" xlink:label="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Compositions of Certain Financial Statement Captions [Abstract] </link:label>
<link:label id="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12_documentation_en-US" xlink:label="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Compositions of Certain Financial Statement Captions [Abstract] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" xlink:label="loc_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12" xlink:to="lab_opk_CompositionsOfCertainFinancialStatementCaptionsAbstract_442CD1AC471DE5931D7DD5B96B52ED12" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCondensedFinancialStatementsTable" xlink:label="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F" xlink:to="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F70F32C2050B59F1D5FAD5B96B52DA5F" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets by Major Class [Axis] </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets by Major Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_49C4137A65584B654691D5B96B5282BD" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_D3540EEEC5CE8290D6DFD5B96B52D75D" xlink:type="arc"/>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B_verboseLabel_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Customer relationships </link:label>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B_label_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Relationships [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B" xlink:to="lab_us-gaap_CustomerRelationshipsMember_58C75AAE09102DD6D267D5B96B52254B" xlink:type="arc"/>
<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A_terseLabel_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Technologies </link:label>
<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A_label_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Technology-Based Intangible Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A" xlink:to="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_C210BF6663BC618B97EAD5B96B52D42A" xlink:type="arc"/>
<link:label id="lab_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656_terseLabel_en-US" xlink:label="lab_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Trade names </link:label>
<link:label id="lab_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656_label_en-US" xlink:label="lab_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Trade Names [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TradeNamesMember" xlink:label="loc_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656" xlink:to="lab_us-gaap_TradeNamesMember_3D4A1EA98A68654E0595D5B96B525656" xlink:type="arc"/>
<link:label id="lab_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D_terseLabel_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Licenses </link:label>
<link:label id="lab_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D_label_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Licensing Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LicensingAgreementsMember" xlink:label="loc_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D" xlink:to="lab_us-gaap_LicensingAgreementsMember_6762C4049C3F9A729B7DD5B96B52AE5D" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D_terseLabel_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Covenants not to compete </link:label>
<link:label id="lab_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D_label_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncompete Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NoncompeteAgreementsMember" xlink:label="loc_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D" xlink:to="lab_us-gaap_NoncompeteAgreementsMember_3E537A7D16CB9D329D23D5B96B52462D" xlink:type="arc"/>
<link:label id="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC_terseLabel_en-US" xlink:label="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product registrations </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC_label_en-US" xlink:label="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC_documentation_en-US" xlink:label="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ProductRegistrationsMember" xlink:label="loc_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:to="lab_opk_ProductRegistrationsMember_68989FBD528395FC436BD5B96B5248DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C_label_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Intangible Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C" xlink:to="lab_us-gaap_OtherIntangibleAssetsMember_2ABDAF2A8F3005287733D5B96B52B10C" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA" xlink:to="lab_us-gaap_BusinessAcquisitionAxis_6ED3BDA1B71BE8A27709D5B96B5297EA" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C" xlink:to="lab_us-gaap_BusinessAcquisitionAcquireeDomain_A444A2EE5DC72E452000D5B96B52B41C" xlink:type="arc"/>
<link:label id="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4_terseLabel_en-US" xlink:label="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4_label_en-US" xlink:label="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:label id="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4_documentation_en-US" xlink:label="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKORentalMember" xlink:label="loc_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:to="lab_opk_OPKORentalMember_D315FB40B3CE5180BAA0D5B96B5225C4" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF_terseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF_label_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF_documentation_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:to="lab_opk_OPKOHealthEuropeMember_69171248435C9BF47452D5B96B5268BF" xlink:type="arc"/>
<link:label id="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8_terseLabel_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8_label_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Opko Diagnostics [Member] </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8_documentation_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:to="lab_opk_OpkoDiagnosticsMember_13F1BA16225BC4510918D5B96B52F7F8" xlink:type="arc"/>
<link:label id="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461_terseLabel_en-US" xlink:label="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CURNA </link:label>
<link:label id="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461_label_en-US" xlink:label="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:label id="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461_documentation_en-US" xlink:label="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:to="lab_opk_CURNAMember_08A9907AB103ABACF42AD5B96B526461" xlink:type="arc"/>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CondensedFinancialStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D" xlink:to="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_94997FF81D3A9CA121ACD5B96B52973D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetAbstract" xlink:label="loc_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3" xlink:to="lab_us-gaap_AccountsReceivableNetAbstract_35E0C94869FE0B8A51E9D5B96B52FEB3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Gross, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0" xlink:to="lab_us-gaap_AccountsReceivableGrossCurrent_0EC16690E6E18DE8A1F8D5B96B52E9F0" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8_negatedLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: allowance for doubtful accounts </link:label>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8_label_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts Receivable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_B90892E002EB6E16BF63D5B96B5301E8" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338_totalLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338" xlink:to="lab_us-gaap_AccountsReceivableNetCurrent_0CD48BCA060E49D0F978D5B96B53F338" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories, net </link:label>
<link:label id="lab_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423_label_en-US" xlink:label="lab_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423" xlink:to="lab_us-gaap_InventoryNetAbstract_158A0DEBBF94AF56E5DCD5B96B53D423" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC_terseLabel_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consumable supplies </link:label>
<link:label id="lab_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC_label_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Inventory, Supplies, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherInventorySupplies" xlink:label="loc_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC" xlink:to="lab_us-gaap_OtherInventorySupplies_3F507BBAA957EC455B8FD5B96B53FCDC" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Finished products </link:label>
<link:label id="lab_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12_label_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Finished Goods, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12" xlink:to="lab_us-gaap_InventoryFinishedGoods_771212093CA1F76CAA04D5B96B53FA12" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Work in-process </link:label>
<link:label id="lab_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7_label_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Work in Process, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7" xlink:to="lab_us-gaap_InventoryWorkInProcess_CA647F6C8B1479EB118AD5B96B53F3D7" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Raw materials </link:label>
<link:label id="lab_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12_label_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Raw Materials, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12" xlink:to="lab_us-gaap_InventoryRawMaterials_AF873C2B78E8BCA932E3D5B96B533C12" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B_negatedLabel_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: inventory reserve </link:label>
<link:label id="lab_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B_label_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Valuation Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B" xlink:to="lab_us-gaap_InventoryValuationReserves_A6E266ACF9BE3CC8B5D0D5B96B53981B" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96_totalLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Inventory, net </link:label>
<link:label id="lab_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96_label_en-US" xlink:label="lab_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96" xlink:to="lab_us-gaap_InventoryNet_FE1C37CE2883D1F53418D5B96B536A96" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_521A0F8EA6BA564B3F49D5B96B53A537" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax assets </link:label>
<link:label id="lab_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Tax Assets, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D" xlink:to="lab_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_C3F9FB778AA447ECA3F0D5B96B530A5D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A_terseLabel_en-US" xlink:label="lab_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid supplies </link:label>
<link:label id="lab_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A_label_en-US" xlink:label="lab_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Supplies </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Supplies" xlink:label="loc_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A" xlink:to="lab_us-gaap_Supplies_E693556E80B4161F3A01D5B96B53C56A" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other receivables </link:label>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A_label_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts and Other Receivables, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A" xlink:to="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_EDE51592556FE2308028D5B96B53125A" xlink:type="arc"/>
<link:label id="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA_terseLabel_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Taxes recoverable </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA_label_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA_documentation_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_TaxesRecoverableCurrent" xlink:label="loc_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:to="lab_opk_TaxesRecoverableCurrent_EB71DF40815EE3050058D5B96B53B3CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10_label_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10" xlink:to="lab_us-gaap_OtherAssetsCurrent_9CC6B5FD67D6943BF1F5D5B96B53ED10" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid insurance </link:label>
<link:label id="lab_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E_label_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Insurance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E" xlink:to="lab_us-gaap_PrepaidInsurance_3AEC224C238658B0F964D5B96B53AA7E" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23_totalLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1916B98549CE08DC4479D5B96B535A23" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net: </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_AA44BE5C23817092F1D8D5B96B539BD8" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsGross_8004DB126EFCFCF135E1D5B96B533C08" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A_negatedLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: accumulated amortization </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Accumulated Amortization </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_7E3271D4FDA6AF3D4749D5B96B53BB3A" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet_F7B2877CF4519DC5ED02D5B96B53C6DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses: </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_A39AC5430562E6F7566FD5B96B53DBEF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C_verboseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C" xlink:to="lab_us-gaap_DeferredRevenueCurrent_BCFE1DDBDD8ECFFEFB88D5B96B54625C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Employee benefits </link:label>
<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64_label_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Employee Benefits, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64" xlink:to="lab_us-gaap_AccruedEmployeeBenefitsCurrent_8E318286CD1F5F6D95D4D5B96B54BF64" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_3B992E38B7B3ED96FD14D5B96B546233" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Taxes payable </link:label>
<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE_label_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Income Taxes, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE" xlink:to="lab_us-gaap_AccruedIncomeTaxesCurrent_1B20D34A92CBD4A693DCD5B96B5459EE" xlink:type="arc"/>
<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases short-term </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeaseObligationsCurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01" xlink:to="lab_us-gaap_CapitalLeaseObligationsCurrent_FCD037ED7695021BBA69D5B96B548A01" xlink:type="arc"/>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC_verboseLabel_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Clinical trials </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC_label_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Clinical Trials, Current </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC_documentation_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accrued clinical trials. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_AccruedClinicalTrialsCurrent" xlink:label="loc_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:to="lab_opk_AccruedClinicalTrialsCurrent_B5138FD3A0BDDB0F864ED5B96B5494BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Professional fees </link:label>
<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45_label_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Professional Fees, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45" xlink:to="lab_us-gaap_AccruedProfessionalFeesCurrent_A4530C264890E7EE602BD5B96B543E45" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96_label_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Deferred Acquisition Payments, Net of Discount, Current </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96_documentation_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Deferred acquisition payments net of discount. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" xlink:label="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:to="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_7A01EA3CBEED44F15680D5BBC6143C96" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442_label_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Accrued Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442" xlink:to="lab_us-gaap_OtherAccruedLiabilitiesCurrent_F6DD64675A5B0CDCC199D5B96B545442" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593_totalLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrent_71C19EAC786B2338A377D5B96B547593" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities: </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Noncurrent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrentAbstract_CB475DACB3B1152B828CD5B96B540635" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105" xlink:to="lab_us-gaap_DeferredRevenueNoncurrent_DF8CED40201CD2A735E1D5B96B546105" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_EE06FF56D41D8A904379D5B96B543391" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Mortgages and other debts payable </link:label>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15_label_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Excluding Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15" xlink:to="lab_us-gaap_LongTermDebtNoncurrent_AC2C736BD72E9F55D85CD5B96B543E15" xlink:type="arc"/>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases long-term </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeaseObligationsNoncurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844" xlink:to="lab_us-gaap_CapitalLeaseObligationsNoncurrent_3F3F4D89A94DADA42067D5B96B549844" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities and Deferred Revenue, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086" xlink:to="lab_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_C344C2FFF97C7809915FD5B96B546086" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities </link:label>
<link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrent_52F5F4493716CF03A9AFD5B96B5496C6" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtDisclosureAbstract_2D7E3AA07E9FD62157A5C96F92479EBA_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureAbstract_2D7E3AA07E9FD62157A5C96F92479EBA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_2D7E3AA07E9FD62157A5C96F92479EBA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureAbstract_2D7E3AA07E9FD62157A5C96F92479EBA" xlink:to="lab_us-gaap_DebtDisclosureAbstract_2D7E3AA07E9FD62157A5C96F92479EBA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078" xlink:to="lab_us-gaap_DebtInstrumentTable_7C829729AEA6870105CAC96F92473078" xlink:type="arc"/>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E_terseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference [Member] </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E_documentation_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" xlink:label="loc_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:to="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_B6889FBA19F9388FD83CC96F9247291E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B" xlink:to="lab_us-gaap_DebtInstrumentLineItems_31618E16FDB46BFF0B50C96F9247044B" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mortgage notes and other debt payables </link:label>
<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F_label_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, by Current and Noncurrent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F" xlink:to="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_131B0594559EF1A522DAC96F9247C21F" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of notes payable </link:label>
<link:label id="lab_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8_label_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8" xlink:to="lab_us-gaap_LongTermDebtCurrent_E34F120EE02DE18F0142C96F92472DD8" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_24E0111AC0F1EDBEEAF8C96F92476F7C_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_24E0111AC0F1EDBEEAF8C96F92476F7C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_24E0111AC0F1EDBEEAF8C96F92476F7C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_24E0111AC0F1EDBEEAF8C96F92476F7C" xlink:to="lab_us-gaap_LongTermDebtNoncurrent_24E0111AC0F1EDBEEAF8C96F92476F7C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total mortgage notes and other debt </link:label>
<link:label id="lab_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F_label_en-US" xlink:label="lab_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F" xlink:to="lab_us-gaap_LongTermDebt_C9C78C94F87E9362A0C5C96F9247B58F" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityAbstract_738270139A8E4538A5796BE7336E63AA_label_en-US" xlink:label="lab_us-gaap_EquityAbstract_5A8C3BAF63CA599C8A0261621F9B096E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_5A8C3BAF63CA599C8A0261621F9B096E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityAbstract_5A8C3BAF63CA599C8A0261621F9B096E" xlink:to="lab_us-gaap_EquityAbstract_5A8C3BAF63CA599C8A0261621F9B096E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_5A968D7D36E969E2085C6BE7336E4C92_verboseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_F586620CFB4D5BB2813F85C0FC12BECC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ACCUMULATED OTHER COMPREHENSIVE INCOME (LOSS) </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_5A968D7D36E969E2085C6BE7336E4C92_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_F586620CFB4D5BB2813F85C0FC12BECC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss) Note [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_F586620CFB4D5BB2813F85C0FC12BECC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_F586620CFB4D5BB2813F85C0FC12BECC" xlink:to="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_F586620CFB4D5BB2813F85C0FC12BECC" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventsAbstract_FDF9D526F465A3A35E0AED2DF3A7A3A7_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsAbstract_FDF9D526F465A3A35E0AED2DF3A7A3A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Events [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_FDF9D526F465A3A35E0AED2DF3A7A3A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsAbstract_FDF9D526F465A3A35E0AED2DF3A7A3A7" xlink:to="lab_us-gaap_SubsequentEventsAbstract_FDF9D526F465A3A35E0AED2DF3A7A3A7" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:label id="lab_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243_label_en-US" xlink:label="lab_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243" xlink:to="lab_us-gaap_VariableRateAxis_53A7E59BA779452AE23FED3182CEE243" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:label id="lab_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610" xlink:to="lab_us-gaap_VariableRateDomain_94807E50861B7B7617A2ED3182DCC610" xlink:type="arc"/>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58_terseLabel_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR </link:label>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58_label_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58" xlink:to="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1B4A0884697F6CE6B975ED3183AC3A58" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E98FC96437BF728C475ED31AF3EE8F8" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR Thereafter </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LondonInterbankOfferedRateLIBORThereafterMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_D8CBC894B965E4A709C5ED31D8C00F00" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_905A75FF3F958EB03B4FED31FF2103CC" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, Thereafter, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_B9647FC35AC74B4D0F4CED32204B6384" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:label id="lab_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D_label_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D" xlink:to="lab_us-gaap_CreditFacilityAxis_DDD176C1B438692E82BBED2DF3A7F73D" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:label id="lab_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E_label_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E" xlink:to="lab_us-gaap_CreditFacilityDomain_863F7C61BED84B337BC0ED2DF3A7DE0E" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10_terseLabel_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility </link:label>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10_label_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10" xlink:to="lab_us-gaap_RevolvingCreditFacilityMember_ACABCAFACAF29E381723ED2DF3A72F10" xlink:type="arc"/>
<link:label id="lab_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585_terseLabel_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Swingline </link:label>
<link:label id="lab_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585_label_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bridge Loan [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BridgeLoanMember" xlink:label="loc_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585" xlink:to="lab_us-gaap_BridgeLoanMember_EE68A6BC5FA5C26499A2ED2DF3A71585" xlink:type="arc"/>
<link:label id="lab_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7_terseLabel_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Letter of Credit </link:label>
<link:label id="lab_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7_label_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Letter of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LetterOfCreditMember" xlink:label="loc_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7" xlink:to="lab_us-gaap_LetterOfCreditMember_144471B10D72C7464BEEED2DF3A7F8E7" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Axis] </link:label>
<link:label id="lab_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE" xlink:to="lab_us-gaap_SubsequentEventTypeAxis_75253FBE4EA9BD6503A7ED2DF3A759DE" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Domain] </link:label>
<link:label id="lab_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74" xlink:to="lab_us-gaap_SubsequentEventTypeDomain_82E74B47031F4E846326ED2DF3A79D74" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subsequent Event </link:label>
<link:label id="lab_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4_label_en-US" xlink:label="lab_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Event [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4" xlink:to="lab_us-gaap_SubsequentEventMember_1FF2CD1A1745A0F98EE3ED2DF3A83CE4" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114" xlink:to="lab_us-gaap_LongtermDebtTypeAxis_BF2866D46F9516177C17ED2DF3A87114" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231" xlink:to="lab_us-gaap_LongtermDebtTypeDomain_29A370BA4550EDA0EFECED2DF3A8B231" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Convertible Notes </link:label>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E_label_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E" xlink:to="lab_us-gaap_ConvertibleNotesPayableMember_15B4F179EDB4A8BA9FF9ED2DF3A8215E" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit </link:label>
<link:label id="lab_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7_label_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7" xlink:to="lab_us-gaap_LineOfCreditMember_CC6BEB8F8D32FAD627F5ED2DF3A8EAB7" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4" xlink:to="lab_us-gaap_DebtInstrumentAxis_552060F8AC6CDAB224D6ED2DF3A8A3B4" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA" xlink:to="lab_us-gaap_DebtInstrumentNameDomain_56E634F7CE48F05D0F02ED2DF3A87DEA" xlink:type="arc"/>
<link:label id="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05_terseLabel_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 </link:label>
<link:label id="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05_label_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 [Member] </link:label>
<link:label id="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05_documentation_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:to="lab_opk_NotesDueFebruary12033Member_C59332031725207E172DED2DF3A8BE05" xlink:type="arc"/>
<link:label id="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C_terseLabel_en-US" xlink:label="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Credit Agreement </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C_label_en-US" xlink:label="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C_documentation_en-US" xlink:label="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_NewCreditAgreementMember" xlink:label="loc_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:to="lab_opk_NewCreditAgreementMember_2A9F6F5E89FE603E9B08ED2DF3A8D18C" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock trigger price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6" xlink:to="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_FCA407F2715BC333951EED2DF3A8EDB6" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Convertible debt, threshold percentage of stock price trigger </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_7B642822948FAAE43F95ED2DF3A8BC47" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_4C5E0522E330BEA4CC22ED2DF3A8E4C5" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of trading days </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_C01D75B109464B1A0B71ED2DF3A8137B" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of consecutive trading days applicable conversion price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Consecutive Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays_3700A0B12FD8547AC8DEED2DF3A80916" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion right triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0_label_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0_documentation_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtInstrumentConvertibleConversionRightTriggered" xlink:label="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:to="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_A40B0994530476350326ED2DF3A847F0" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Ratio </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_154C78AD737E5F6410DFED2DF3A881E1" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit line capacity </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Maximum Borrowing Capacity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03" xlink:to="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_CA3B1B81195243160BF6ED2DF3A9FB03" xlink:type="arc"/>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3_terseLabel_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Higher borrowing capacity option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3_label_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3_documentation_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" xlink:label="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:to="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_30BC92038115CFEBD021ED31525C7CA3" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Basis spread on variable rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Basis Spread on Variable Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B" xlink:to="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_72C11A33641AC21FC829ED3181E4393B" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Commitment fee percentage </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Commitment Fee Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA" xlink:to="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_271704C662A204C434D7ED3073A402DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsAbstract_4D57CC5D828EA039679D6BE7350C4871_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsAbstract_D3AE9085915B5E9BA5B08870642271DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transactions [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_D3AE9085915B5E9BA5B08870642271DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_D3AE9085915B5E9BA5B08870642271DA" xlink:to="lab_us-gaap_RelatedPartyTransactionsAbstract_D3AE9085915B5E9BA5B08870642271DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_C024CF9A89F264507F826BE7350CDCA8_verboseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_66BEBFD3C99D54CFADFA079452632FA2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> RELATED PARTY TRANSACTIONS </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_C024CF9A89F264507F826BE7350CDCA8_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_66BEBFD3C99D54CFADFA079452632FA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transactions Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_66BEBFD3C99D54CFADFA079452632FA2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_66BEBFD3C99D54CFADFA079452632FA2" xlink:to="lab_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_66BEBFD3C99D54CFADFA079452632FA2" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_2B8C0EFA8E22C8C754CD6BE7336027E6_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock_F16641DD057358D59167C5F2C13E9EFB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ACQUISITIONS, INVESTMENTS, AND LICENSES </link:label>
<link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_2B8C0EFA8E22C8C754CD6BE7336027E6_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock_F16641DD057358D59167C5F2C13E9EFB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock_F16641DD057358D59167C5F2C13E9EFB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationDisclosureTextBlock_F16641DD057358D59167C5F2C13E9EFB" xlink:to="lab_us-gaap_BusinessCombinationDisclosureTextBlock_F16641DD057358D59167C5F2C13E9EFB" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_49ABB88320086746213AA50A079B4D57" xlink:type="arc"/>
<link:label id="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11_terseLabel_en-US" xlink:label="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Bio-Reference </link:label>
<link:label id="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11_label_en-US" xlink:label="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bio-Reference [Member] </link:label>
<link:label id="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11_documentation_en-US" xlink:label="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bio-Reference [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BioReferenceMember" xlink:label="loc_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:to="lab_opk_BioReferenceMember_33D40FB8A0A9724CCD83A50A079B1B11" xlink:type="arc"/>
<link:label id="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344_verboseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> EirGen </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344_documentation_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EirGenPharmaLimitedMember" xlink:label="loc_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:to="lab_opk_EirGenPharmaLimitedMember_A08AA1A56AD6C01BDF0EA50A079B3344" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Line Items] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501" xlink:to="lab_us-gaap_BusinessAcquisitionLineItems_A76ACE69F13B8D3D8F3EA50A079BF501" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2" xlink:to="lab_us-gaap_BusinessAcquisitionsProFormaRevenue_4E84C40A4A32F3F34F38A50A079C39C2" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7" xlink:to="lab_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0AAE81E24E14413E664FA50A079C9CC7" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) attributable to common shareholders </link:label>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB_label_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) Available to Common Stockholders </link:label>
<link:label id="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Net Income (Loss) Available to Common Stockholders </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders" xlink:label="loc_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:to="lab_opk_BusinessAcquisitionProFormaNetIncomeLossAvailabletoCommonStockholders_B2B0E965A2752D43BA38A50A079CF0DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosuresAbstract_62ACF2806574FC2A57A0C96F9215F4B9_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract_62ACF2806574FC2A57A0C96F9215F4B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_62ACF2806574FC2A57A0C96F9215F4B9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_62ACF2806574FC2A57A0C96F9215F4B9" xlink:to="lab_us-gaap_FairValueDisclosuresAbstract_62ACF2806574FC2A57A0C96F9215F4B9" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_E56B2820849DBF8C8F59C96F92159039" xlink:type="arc"/>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Axis] </link:label>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_2E4A728BCE9680FEC8DCC96F9215384D" xlink:type="arc"/>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135_terseLabel_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Domain] </link:label>
<link:label id="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135_label_en-US" xlink:label="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Major Types of Debt and Equity Securities [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135" xlink:to="lab_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_20BAB53BA4DD5EC39092C96F92168135" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock investments, available for sale </link:label>
<link:label id="lab_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB_label_en-US" xlink:label="lab_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB" xlink:to="lab_us-gaap_CommonStockMember_5CE80B28A47CF2E3833FC96F921614CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock options/warrants </link:label>
<link:label id="lab_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt Securities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5" xlink:to="lab_us-gaap_ConvertibleDebtSecuritiesMember_3A6C21BA22B3940A90B7C96F9216FCA5" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Line Items] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_41A0346A687D4C520F89C96F92166EE4" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440_totalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Amortized Cost </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Amortized Cost Basis </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAmortizedCost_643E4EB795592ACF59E6C96F92167440" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gross unrealized gains in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3C5CCAFD5582C8C91EEFC96F921675B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Gross unrealized losses in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_E38E30FE85E38F51902AC96F92169EFC" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298_negatedLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Realized Gain/(Loss) in Accumulated Deficit </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298_label_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Accumulated Gross Realized Gain (Loss), Net </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298_documentation_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Accumulated Gross Realized Gain (Loss), Net </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet" xlink:label="loc_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:to="lab_opk_AvailableforSaleSecuritiesAccumulatedGrossRealizedGainLossNet_70C5994BB94677F4A1B8C96F9216C298" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7" xlink:to="lab_us-gaap_AvailableForSaleSecurities_6402238D15A42EACFDA4C96F9216D1F7" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_FC99E7AC65FCFA9B2A79B7E28BC8530C_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_D361859C8B2E57A09F50DB9104ED9CB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_D361859C8B2E57A09F50DB9104ED9CB8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleNotesPayableMember_D361859C8B2E57A09F50DB9104ED9CB8" xlink:to="lab_us-gaap_ConvertibleNotesPayableMember_D361859C8B2E57A09F50DB9104ED9CB8" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentRollForward_2A013412160340F0BC19B7E28BC841B4_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_2A013412160340F0BC19B7E28BC841B4_label_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_2A013412160340F0BC19B7E28BC841B4_documentation_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtInstrumentRollForward" xlink:label="loc_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:to="lab_opk_DebtInstrumentRollForward_823A1E53EA9C536FB85D67A4B36AB041" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A519FA60AC3220C5134FB7E28BC86C30_periodStartLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_51B9131BC8C45B35ABFA85D33F666B10" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Embedded derivatives, beginning balance </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_A519FA60AC3220C5134FB7E28BC86C30_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_51B9131BC8C45B35ABFA85D33F666B10" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Fair Value of Embedded Derivative Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_51B9131BC8C45B35ABFA85D33F666B10" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_51B9131BC8C45B35ABFA85D33F666B10" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_51B9131BC8C45B35ABFA85D33F666B10" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_5F0C2E29E2CFA86D51CFB7E28BC89D57_periodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_FA59977F3FD55A81967D9F5E1B8AB3E3" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Convertible notes, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_5F0C2E29E2CFA86D51CFB7E28BC89D57_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_FA59977F3FD55A81967D9F5E1B8AB3E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_FA59977F3FD55A81967D9F5E1B8AB3E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_FA59977F3FD55A81967D9F5E1B8AB3E3" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_FA59977F3FD55A81967D9F5E1B8AB3E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_B23B5BC40BA1CED69594B7E28BC8F607_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_06E7314DBCEA5E0792E43F8494961A19" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US"> Discount, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_B23B5BC40BA1CED69594B7E28BC8F607_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_06E7314DBCEA5E0792E43F8494961A19" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Unamortized Discount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_06E7314DBCEA5E0792E43F8494961A19" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_06E7314DBCEA5E0792E43F8494961A19" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_06E7314DBCEA5E0792E43F8494961A19" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_0809AD3479BA3DFFA5F4B7E28BC9D392_periodStartLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_1DD38238BA015A8C8215D8C379B78AD1" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Total, beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_1DD38238BA015A8C8215D8C379B78AD1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_1DD38238BA015A8C8215D8C379B78AD1" xlink:to="lab_us-gaap_LongTermDebt_1DD38238BA015A8C8215D8C379B78AD1" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_E54635C1E777E7DD1F53B7E28BC95554_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_33AD7654BE13550DBD4A75ADD75350BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt discount </link:label>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_E54635C1E777E7DD1F53B7E28BC95554_label_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_33AD7654BE13550DBD4A75ADD75350BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Discount (Premium) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_33AD7654BE13550DBD4A75ADD75350BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfDebtDiscountPremium_33AD7654BE13550DBD4A75ADD75350BF" xlink:to="lab_us-gaap_AmortizationOfDebtDiscountPremium_33AD7654BE13550DBD4A75ADD75350BF" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6596067FF843A3CCFA5BB7E28BC965D9_verboseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_FECCA9176FA953B6B05CE39CD1696DC0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of embedded derivative </link:label>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6596067FF843A3CCFA5BB7E28BC965D9_label_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_FECCA9176FA953B6B05CE39CD1696DC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Derivative Instruments, Net, Pretax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_FECCA9176FA953B6B05CE39CD1696DC0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_FECCA9176FA953B6B05CE39CD1696DC0" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_FECCA9176FA953B6B05CE39CD1696DC0" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_326C738EEB702A65FF92B7E28BC9B325_negatedTerseLabel_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, conversion </link:label>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_326C738EEB702A65FF92B7E28BC9B325_label_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Embedded Derivative, Amount </link:label>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_326C738EEB702A65FF92B7E28BC9B325_documentation_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Embedded Derivative, Amount </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtConversionEmbeddedDerivativeAmount" xlink:label="loc_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:to="lab_opk_DebtConversionEmbeddedDerivativeAmount_FB64B44694035D8590925A2579DDA0F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_8ACD447CACD6E89A4056B7E28BC93CDA_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_60D2D3301F285693983B02A664AD941F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Convertible notes, conversion </link:label>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_8ACD447CACD6E89A4056B7E28BC93CDA_label_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_60D2D3301F285693983B02A664AD941F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Original Debt, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="loc_us-gaap_DebtConversionOriginalDebtAmount1_60D2D3301F285693983B02A664AD941F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionOriginalDebtAmount1_60D2D3301F285693983B02A664AD941F" xlink:to="lab_us-gaap_DebtConversionOriginalDebtAmount1_60D2D3301F285693983B02A664AD941F" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0AD5B1DB5B5FD6DADDC1B7E28BC97EE2_terseLabel_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discount, conversion </link:label>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0AD5B1DB5B5FD6DADDC1B7E28BC97EE2_label_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Debt Discount, Amount </link:label>
<link:label id="lab_opk_DebtConversionDebtDiscountAmount_0AD5B1DB5B5FD6DADDC1B7E28BC97EE2_documentation_en-US" xlink:label="lab_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Debt Discount, Amount </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtConversionDebtDiscountAmount" xlink:label="loc_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:to="lab_opk_DebtConversionDebtDiscountAmount_05A50DA882795A8B88E2F46C7E32EB1B" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_F8E2E50C2C949E93BD42B7E28BCE353C_negatedTerseLabel_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Conversion </link:label>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_F8E2E50C2C949E93BD42B7E28BCE353C_label_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Long-term Debt, Amount </link:label>
<link:label id="lab_opk_DebtConversionLongtermDebtAmount_F8E2E50C2C949E93BD42B7E28BCE353C_documentation_en-US" xlink:label="lab_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Long-term Debt, Amount </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtConversionLongtermDebtAmount" xlink:label="loc_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:to="lab_opk_DebtConversionLongtermDebtAmount_1B226953476F5BCAAEA8B58ABC3390F1" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_EC345FD29540CC570D73B7E28BCE8E7B_periodEndLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_706F7C60F2095CEA96BD738BBF46CD11" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Embedded derivatives, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_706F7C60F2095CEA96BD738BBF46CD11" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_706F7C60F2095CEA96BD738BBF46CD11" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_706F7C60F2095CEA96BD738BBF46CD11" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_76D65FACA3D6C3C92F2CB7E28BCE745F_periodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_3E14863383B25CEFBBAAB800719DCC00" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Convertible notes, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_3E14863383B25CEFBBAAB800719DCC00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_3E14863383B25CEFBBAAB800719DCC00" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_3E14863383B25CEFBBAAB800719DCC00" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_73265A881AB7EE98E4EEB7E28BCE4CBC_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_F8D2E5574A4A58BF88D32C7ADECAC141" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US"> Discount, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_F8D2E5574A4A58BF88D32C7ADECAC141" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_F8D2E5574A4A58BF88D32C7ADECAC141" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_F8D2E5574A4A58BF88D32C7ADECAC141" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_943B157DAB7ABED3276BB7E28BCE673B_periodEndLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_4BF60453B8695560B368FD7B522A04A3" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Total, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_4BF60453B8695560B368FD7B522A04A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_4BF60453B8695560B368FD7B522A04A3" xlink:to="lab_us-gaap_LongTermDebt_4BF60453B8695560B368FD7B522A04A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_1E5F443D49AA2AC3F4746BE734A5CFD2_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_9854D038E1B65AE4BA5C6D314417D37B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments and Hedging Activities Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_9854D038E1B65AE4BA5C6D314417D37B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_9854D038E1B65AE4BA5C6D314417D37B" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_9854D038E1B65AE4BA5C6D314417D37B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_DFDD38D093DF461E1B256BE734A5A67C_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_6DD8D6AC7831522B9F874B9429A26C9F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of fair values and derivative financial instrument </link:label>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_DFDD38D093DF461E1B256BE734A5A67C_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_6DD8D6AC7831522B9F874B9429A26C9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Derivative Instruments in Statement of Financial Position, Fair Value [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_6DD8D6AC7831522B9F874B9429A26C9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_6DD8D6AC7831522B9F874B9429A26C9F" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_6DD8D6AC7831522B9F874B9429A26C9F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_478253CED3FA3E247E436BE734A51189_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_E8D3DAFA97755CFC8BD14CE7261DEF6A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of (losses) and gains recorded in Fair value changes of derivative financial instruments </link:label>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_478253CED3FA3E247E436BE734A51189_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_E8D3DAFA97755CFC8BD14CE7261DEF6A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_E8D3DAFA97755CFC8BD14CE7261DEF6A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_E8D3DAFA97755CFC8BD14CE7261DEF6A" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsGainLossInStatementOfFinancialPerformanceTextBlock_E8D3DAFA97755CFC8BD14CE7261DEF6A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_3A2260FE05FE10EC2E5E6BE734A50E22_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_FA3E7B78ADA45B8C904995DE044D2A8F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Outstanding contracts recorded at fair value and their maturity details </link:label>
<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_3A2260FE05FE10EC2E5E6BE734A50E22_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_FA3E7B78ADA45B8C904995DE044D2A8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Derivative Instruments [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_FA3E7B78ADA45B8C904995DE044D2A8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_FA3E7B78ADA45B8C904995DE044D2A8F" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_FA3E7B78ADA45B8C904995DE044D2A8F" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementAbstract_3E737319C54F5205834AD9300976C20F_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract_3E737319C54F5205834AD9300976C20F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_3E737319C54F5205834AD9300976C20F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementAbstract_3E737319C54F5205834AD9300976C20F" xlink:to="lab_us-gaap_IncomeStatementAbstract_3E737319C54F5205834AD9300976C20F" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenues: </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueNetAbstract" xlink:label="loc_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B" xlink:to="lab_us-gaap_SalesRevenueNetAbstract_5AF1011422BE5DFD0E41D9300976679B" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779_label_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Services, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779" xlink:to="lab_us-gaap_SalesRevenueServicesNet_AD839206F20545A49A08D9300976E779" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from products </link:label>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A_label_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Goods, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A" xlink:to="lab_us-gaap_SalesRevenueGoodsNet_577C28B530916247475BD93009763C9A" xlink:type="arc"/>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67_verboseLabel_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other revenue, principally transfer of intellectual property </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67_label_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67_documentation_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_RevenueFromTransferOfIntellectualProperty" xlink:label="loc_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:to="lab_opk_RevenueFromTransferOfIntellectualProperty_E6FFEEA3BC22F2E1045DD93009767A67" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE_totalLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:label id="lab_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE" xlink:to="lab_us-gaap_SalesRevenueNet_D18F855550E7BB491F76D930097708AE" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE_verboseLabel_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Costs and expenses: </link:label>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE_label_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingExpensesAbstract" xlink:label="loc_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE" xlink:to="lab_us-gaap_OperatingExpensesAbstract_A97831ACF6BAC0EC0942D93009779DEE" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of service revenue </link:label>
<link:label id="lab_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4_label_en-US" xlink:label="lab_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfServices" xlink:label="loc_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4" xlink:to="lab_us-gaap_CostOfServices_3235AFA50E62EF8F93DCD9300977B9D4" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of product revenue </link:label>
<link:label id="lab_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C_label_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Goods Sold </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C" xlink:to="lab_us-gaap_CostOfGoodsSold_0D8FC016B8578A187435D9300977218C" xlink:type="arc"/>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E_verboseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Selling, general and administrative </link:label>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E_label_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E" xlink:to="lab_us-gaap_SellingGeneralAndAdministrativeExpense_4D1C1538E971093B64A8D9300977522E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688_verboseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Research and development </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpense_0AF82F2975CCCE1AD2C9D9300977B688" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> In-process research and development </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development in Process </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentInProcess" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D" xlink:to="lab_us-gaap_ResearchAndDevelopmentInProcess_11D8B5F0629414BEA1CDD93009781C5D" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_11AEA53270D0EC05256AD93009784060" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of intangible assets </link:label>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Intangible Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE" xlink:to="lab_us-gaap_AmortizationOfIntangibleAssets_38221C7E01D70C8C70A4D93009784DDE" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Grant repayment </link:label>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D_label_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Grant Repayment </link:label>
<link:label id="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Grant Repayment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementGrantRepayment" xlink:label="loc_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:to="lab_opk_CollaborativeArrangementGrantRepayment_B909AF46BEEA0DC0D255D9300978E98D" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total costs and expenses </link:label>
<link:label id="lab_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D_label_en-US" xlink:label="lab_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D" xlink:to="lab_us-gaap_OperatingExpenses_13FBA22765D60BA1334AD9300978863D" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Operating income (loss) </link:label>
<link:label id="lab_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC_label_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC" xlink:to="lab_us-gaap_OperatingIncomeLoss_8AE58984A49943BA799BD9300978F5FC" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net: </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_0F1B4D80AB37CD743CCFD93009781BA6" xlink:type="arc"/>
<link:label id="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8_verboseLabel_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest income </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8_label_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8_documentation_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_InterestIncomeNonoperating" xlink:label="loc_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:to="lab_opk_InterestIncomeNonoperating_EB12924BE6BE2E7BAAADD930097848D8" xlink:type="arc"/>
<link:label id="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A_negatedLabel_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Interest expense </link:label>
<link:label id="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A_label_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense, Nonoperating </link:label>
<link:label id="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A_documentation_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Expense, Nonoperating </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_InterestExpenseNonoperating" xlink:label="loc_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:to="lab_opk_InterestExpenseNonoperating_FE47F0229298D0E8F505D9300979436A" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F378E8867810079DB717D93009791DFD_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F378E8867810079DB717D93009791DFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value changes of derivative instruments, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F378E8867810079DB717D93009791DFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F378E8867810079DB717D93009791DFD" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_F378E8867810079DB717D93009791DFD" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income (expense), net </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpense_C9149A5EAF8B632E5DBCD9300979D90C" xlink:type="arc"/>
<link:label id="lab_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA_totalLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net </link:label>
<link:label id="lab_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA_label_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA" xlink:to="lab_us-gaap_NonoperatingIncomeExpense_1F7B9626E5DEFAACBC10D9300979A0DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Income (loss) before income taxes and investment losses </link:label>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5DC69CF3E4266663AB27D930097918A1" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Income tax benefit (provision) </link:label>
<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250" xlink:to="lab_us-gaap_IncomeTaxExpenseBenefit_7CCC8382159B3B968A68D9300979F250" xlink:type="arc"/>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20_totalLabel_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Income (loss) before investment losses </link:label>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20_label_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations, Before Investments in Investees, Extraordinary Items, Noncontrolling Interest, Net of Tax </link:label>
<link:label id="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20_documentation_en-US" xlink:label="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Gain (loss) from continuing operations before investment losses. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" xlink:label="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:to="lab_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax_9ADB32B1ED4A3E8BDC64D93009797F20" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Loss from investments in investees </link:label>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments_5F572ACD459CD688ACCCD9300979517B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E_totalLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:label id="lab_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E_label_en-US" xlink:label="lab_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss), Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E" xlink:to="lab_us-gaap_ProfitLoss_DD816047CC7C46F7614AD930097A3C0E" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Less: Net loss attributable to noncontrolling interests </link:label>
<link:label id="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6" xlink:to="lab_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9CCE72EE3495C5BEC51AD930097ADDB6" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375_totalLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) attributable to common shareholders </link:label>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Available to Common Stockholders, Basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_1005091E12EFF560C34BD930097A2375" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Earnings (loss) per share, basic (usd per share) </link:label>
<link:label id="lab_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share, Basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392" xlink:to="lab_us-gaap_EarningsPerShareBasic_24FAD14EBB667EECC330D930097AC392" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings (loss) per share, diluted (usd per share) </link:label>
<link:label id="lab_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share, Diluted </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F" xlink:to="lab_us-gaap_EarningsPerShareDiluted_0A691AADFB97FAA1536CD930097A9A6F" xlink:type="arc"/>
<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average common shares outstanding, basic (shares) </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_95825B956B60FF162782D930097AE59F" xlink:type="arc"/>
<link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average common shares outstanding, diluted (shares) </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Diluted </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8" xlink:to="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CD4338B50EF8355340C1D930097A20E8" xlink:type="arc"/>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_877D1530BCA41B1F66D26BE734DF219C_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A474DC4DEB455BB5BF732A59ACBD0B1F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Organization, Consolidation and Presentation of Financial Statements [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A474DC4DEB455BB5BF732A59ACBD0B1F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A474DC4DEB455BB5BF732A59ACBD0B1F" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A474DC4DEB455BB5BF732A59ACBD0B1F" xlink:type="arc"/>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_2C94B406FE5FC133C54C6BE734DF6734_verboseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4AD92F7FC4C658039BF7D3994D0E4F5B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BUSINESS AND ORGANIZATION </link:label>
<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_2C94B406FE5FC133C54C6BE734DF6734_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4AD92F7FC4C658039BF7D3994D0E4F5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4AD92F7FC4C658039BF7D3994D0E4F5B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4AD92F7FC4C658039BF7D3994D0E4F5B" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4AD92F7FC4C658039BF7D3994D0E4F5B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_83FE0863674894BD54FA873CED20F276" xlink:type="arc"/>
<link:label id="lab_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Axis] </link:label>
<link:label id="lab_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67" xlink:to="lab_us-gaap_BalanceSheetLocationAxis_B7CEF5C1DD18AFC0E027873CED20EB67" xlink:type="arc"/>
<link:label id="lab_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:label id="lab_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E" xlink:to="lab_us-gaap_BalanceSheetLocationDomain_DEA85EECA6A2389C8708873CED20988E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued Expenses </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866" xlink:to="lab_us-gaap_AccruedLiabilitiesMember_B3E1BA8590D78C4083D1873CED200866" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97_terseLabel_en-US" xlink:label="lab_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Noncurrent Liabilities </link:label>
<link:label id="lab_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97_label_en-US" xlink:label="lab_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Noncurrent Liabilities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97" xlink:to="lab_us-gaap_OtherNoncurrentLiabilitiesMember_8D02931137109475AECC873CED20ED97" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8_terseLabel_en-US" xlink:label="lab_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:label id="lab_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8_label_en-US" xlink:label="lab_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8" xlink:to="lab_us-gaap_RangeAxis_AA20EF0E14C691FB3E99873CED20F3A8" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA_terseLabel_en-US" xlink:label="lab_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:label id="lab_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA_label_en-US" xlink:label="lab_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA" xlink:to="lab_us-gaap_RangeMember_8A2F897C26DAC74ABD55873CED204CAA" xlink:type="arc"/>
<link:label id="lab_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7_terseLabel_en-US" xlink:label="lab_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Minimum </link:label>
<link:label id="lab_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7_label_en-US" xlink:label="lab_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Minimum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7" xlink:to="lab_us-gaap_MinimumMember_F767D9FBF784E3C917C2873CED20D4A7" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49_verboseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maximum </link:label>
<link:label id="lab_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49_label_en-US" xlink:label="lab_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Maximum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49" xlink:to="lab_us-gaap_MaximumMember_F37F52BA2DB0D5A0D784873CED20EF49" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C1EF9FA949EA156850AC873CED206585" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Discount rates related to consideration </link:label>
<link:label id="lab_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE_label_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Discount Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE" xlink:to="lab_us-gaap_FairValueInputsDiscountRate_580DD9F4CBBD4563558C873CED217DBE" xlink:type="arc"/>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB_terseLabel_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of increase in discount rate </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB_label_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Percentage Of Increase Decrease In Discount Rate </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB_documentation_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Percentage of increase decrease in discount rate. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PercentageOfIncreaseDecreaseInDiscountRate" xlink:label="loc_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:to="lab_opk_PercentageOfIncreaseDecreaseInDiscountRate_6690630371B6A168F251873CED21BDBB" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A_negatedLabel_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Decrease in contingent consideration on discount rates increase </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A_label_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination Contingent Consideration Arrangements Change In Amount Of Contingent Consideration If Discount Rates Increase One Percent </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A_documentation_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination Contingent Consideration Arrangements Change In Amount Of Contingent Consideration If Discount Rates Increase One Percent </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:to="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfDiscountRatesIncreaseOnePercent_164EE86572AE9D1E87EC873CED216B4A" xlink:type="arc"/>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB_negatedTerseLabel_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of decrease in future sales </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB_label_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Percentage Of Increase Decrease In Future Sales </link:label>
<link:label id="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB_documentation_en-US" xlink:label="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Percentage of increase decrease in future sales. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PercentageOfIncreaseDecreaseInFutureSales" xlink:label="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:to="lab_opk_PercentageOfIncreaseDecreaseInFutureSales_66A01E2B8AEFD63196A1873CED21C0AB" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103_negatedLabel_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Decrease of estimated future sales in amount </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103_label_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination Contingent Consideration Arrangements Change In Amount Of Contingent Consideration If Estimated Future Sales Decrease Ten Percent </link:label>
<link:label id="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103_documentation_en-US" xlink:label="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business combination contingent consideration arrangements change in amount of contingent consideration if estimated future sales decrease ten percent. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" xlink:label="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:to="lab_opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent_E32E1D0907AA095446D1873CED21E103" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationLiability_AB255C4E6F42457C1F01873CED21E4E9" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_B3B6B82E7674B35D8FFEC1301D574C17_terseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investments, investment carrying value </link:label>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_B3B6B82E7674B35D8FFEC1301D574C17_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Excluding Variable Interes tEntity </link:label>
<link:label id="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_B3B6B82E7674B35D8FFEC1301D574C17_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Excluding Variable Interes tEntity </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EquityMethodInvestmentExcludingVariableInterestEntity" xlink:label="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:to="lab_opk_EquityMethodInvestmentExcludingVariableInterestEntity_CAD9AAF97878503CB5B3CB51FAC38518" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_64FA3CAA2E807C7907CAC1301D571F09_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_8FCB211791C159999FF2E3C9E22E5460" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investment, underlying equity in net assets </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_64FA3CAA2E807C7907CAC1301D571F09_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_8FCB211791C159999FF2E3C9E22E5460" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Underlying Equity in Net Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_8FCB211791C159999FF2E3C9E22E5460" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_8FCB211791C159999FF2E3C9E22E5460" xlink:to="lab_us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets_8FCB211791C159999FF2E3C9E22E5460" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_1202D0758E9E6C86F467C1301D58C4CF_terseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest entity, equity method </link:label>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_1202D0758E9E6C86F467C1301D58C4CF_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Variable Interest Entity </link:label>
<link:label id="lab_opk_EquityMethodInvestmentVariableInterestEntity_1202D0758E9E6C86F467C1301D58C4CF_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Variable Interest Entity </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EquityMethodInvestmentVariableInterestEntity" xlink:label="loc_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:to="lab_opk_EquityMethodInvestmentVariableInterestEntity_8D2A0374629F596EB05392174E966C63" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_55CB336062A0B3C76EA9C1301D5846AA_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_ACE7EF56C3155E49A82D31DC05444F54" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Available for sale investments </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_55CB336062A0B3C76EA9C1301D5846AA_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_ACE7EF56C3155E49A82D31DC05444F54" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_ACE7EF56C3155E49A82D31DC05444F54" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_ACE7EF56C3155E49A82D31DC05444F54" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesNoncurrent_ACE7EF56C3155E49A82D31DC05444F54" xlink:type="arc"/>
<link:label id="lab_opk_StockOptionandWarrantInvestments_A724D0A59322125D578AC1301D58DD6C_terseLabel_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Warrants and options </link:label>
<link:label id="lab_opk_StockOptionandWarrantInvestments_A724D0A59322125D578AC1301D58DD6C_label_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Option and Warrant Investments </link:label>
<link:label id="lab_opk_StockOptionandWarrantInvestments_A724D0A59322125D578AC1301D58DD6C_documentation_en-US" xlink:label="lab_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Option and Warrant Investments </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_StockOptionandWarrantInvestments" xlink:label="loc_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:to="lab_opk_StockOptionandWarrantInvestments_1B6DE881F26F5D8A80C6C1D0F21EB301" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermInvestments_40496D8E9D9132E206FDC1301D581ABE_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_3B39C0634DAC585A843B753A21DD0E88" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total carrying value of investments </link:label>
<link:label id="lab_us-gaap_LongTermInvestments_40496D8E9D9132E206FDC1301D581ABE_label_en-US" xlink:label="lab_us-gaap_LongTermInvestments_3B39C0634DAC585A843B753A21DD0E88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_3B39C0634DAC585A843B753A21DD0E88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermInvestments_3B39C0634DAC585A843B753A21DD0E88" xlink:to="lab_us-gaap_LongTermInvestments_3B39C0634DAC585A843B753A21DD0E88" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6_label_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6" xlink:to="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_48132FAA3C6B82275E33CEBF49EA58F6" xlink:type="arc"/>
<link:label id="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135_terseLabel_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> VBIV </link:label>
<link:label id="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135_label_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> VBI Vaccines Inc [Member] </link:label>
<link:label id="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135_documentation_en-US" xlink:label="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> VBI Vaccines Inc [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_VBIVaccinesIncMember" xlink:label="loc_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:to="lab_opk_VBIVaccinesIncMember_390422D813430B49B90BCEC0FF05F135" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Axis] </link:label>
<link:label id="lab_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369" xlink:to="lab_us-gaap_IncomeStatementLocationAxis_5A749001317257BB0F2BCEBF49EB8369" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:label id="lab_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A" xlink:to="lab_us-gaap_IncomeStatementLocationDomain_78F4EE15E48FCA1C83BACEBF49EBC22A" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B_terseLabel_en-US" xlink:label="lab_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Income (Expense) </link:label>
<link:label id="lab_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B_label_en-US" xlink:label="lab_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Operating Income (Expense) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherOperatingIncomeExpenseMember" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B" xlink:to="lab_us-gaap_OtherOperatingIncomeExpenseMember_3DA05E3C74B21CFBEE1FCEBF49EB154B" xlink:type="arc"/>
<link:label id="lab_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300_terseLabel_en-US" xlink:label="lab_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Legal Entity [Axis] </link:label>
<link:label id="lab_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300_label_en-US" xlink:label="lab_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Legal Entity [Axis] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300" xlink:to="lab_dei_LegalEntityAxis_CC12126B23B0BBB327ADCEBF49EBC300" xlink:type="arc"/>
<link:label id="lab_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8_terseLabel_en-US" xlink:label="lab_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity [Domain] </link:label>
<link:label id="lab_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8_label_en-US" xlink:label="lab_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity [Domain] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8" xlink:to="lab_dei_EntityDomain_B52E5F27CF2BDF98B8F3CEBF49EB5CF8" xlink:type="arc"/>
<link:label id="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B_terseLabel_en-US" xlink:label="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> SciVac </link:label>
<link:label id="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B_label_en-US" xlink:label="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SciVac [Member] </link:label>
<link:label id="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B_documentation_en-US" xlink:label="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> SciVac [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SciVacMember" xlink:label="loc_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:to="lab_opk_SciVacMember_48EC9F4CBFDED3AB3493CEBF49EB3A8B" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entities [Axis] </link:label>
<link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC" xlink:to="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_82C6507C2316F8A0882CCEBF49EB20DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD_terseLabel_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Classification [Domain] </link:label>
<link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD_label_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Classification [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD" xlink:to="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_D1F9F695E755F76B16B5CEBF49EB0DFD" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Primary Beneficiary </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Primary Beneficiary [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480" xlink:to="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_ACEDFB8C82F850E7FFA7CEBF49EB1480" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD_label_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD" xlink:to="lab_us-gaap_StatementClassOfStockAxis_B38F4102481A4C3F310DCEBF49EBEDFD" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:label id="lab_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3" xlink:to="lab_us-gaap_ClassOfStockDomain_19AB6B9DCF8117C37F29CEBF49EB49F3" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series A Preferred Stock </link:label>
<link:label id="lab_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8_label_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Series A Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8" xlink:to="lab_us-gaap_SeriesAPreferredStockMember_1CDCF6FA12F532F13E08CEBF49EB57F8" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restricted Stock </link:label>
<link:label id="lab_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F_label_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restricted Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F" xlink:to="lab_us-gaap_RestrictedStockMember_5E920B4338F9B831AC95CEBF49EB6A5F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment, Name [Axis] </link:label>
<link:label id="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247" xlink:to="lab_us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_4AD3F8383C9851441294CEBF49EC3247" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment, Name [Domain] </link:label>
<link:label id="lab_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="loc_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146" xlink:to="lab_us-gaap_EquityMethodInvesteeNameDomain_C297E39A0A2B6C692BB7CEBF49EC2146" xlink:type="arc"/>
<link:label id="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF_terseLabel_en-US" xlink:label="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Zebra </link:label>
<link:label id="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF_label_en-US" xlink:label="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:label id="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF_documentation_en-US" xlink:label="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ZebraMember" xlink:label="loc_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:to="lab_opk_ZebraMember_D8D2810F1F7B3D4CA85FCEBF49ECCAEF" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F" xlink:to="lab_us-gaap_VariableInterestEntityLineItems_3A56F032D00096F5C079CEBF49EC9F8F" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment owned, shares </link:label>
<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661_label_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment Owned, Balance, Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentOwnedBalanceShares" xlink:label="loc_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661" xlink:to="lab_us-gaap_InvestmentOwnedBalanceShares_8A5E51581B68A9A659BFCEBF49EC1661" xlink:type="arc"/>
<link:label id="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D_terseLabel_en-US" xlink:label="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares received as a gift </link:label>
<link:label id="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D_label_en-US" xlink:label="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Received As Gift </link:label>
<link:label id="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D_documentation_en-US" xlink:label="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares Received As Gift </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SharesReceivedAsGift" xlink:label="loc_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:to="lab_opk_SharesReceivedAsGift_FD4C1F2EBCE6BBDB0D49CEBF49EC761D" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock ownership percentage </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="loc_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0" xlink:to="lab_us-gaap_VariableInterestEntityOwnershipPercentage_DDCE5643EA14A6B6824BCEBF49EC2DC0" xlink:type="arc"/>
<link:label id="lab_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B_terseLabel_en-US" xlink:label="lab_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional working capital </link:label>
<link:label id="lab_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B_label_en-US" xlink:label="lab_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Due from Affiliates </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DueFromAffiliates" xlink:label="loc_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B" xlink:to="lab_us-gaap_DueFromAffiliates_C34FA9B970EB0800E831CEBF49ECB97B" xlink:type="arc"/>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703_terseLabel_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of members of board of directors </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703_label_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Number of Members of Board of Directors </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703_documentation_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Number of Members of Board of Directors </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:to="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors_062E686F63F3DB7F2BD8CEBF49ECF703" xlink:type="arc"/>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A_terseLabel_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of members of board of directors appointed by reporting entity </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A_label_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Number of Members of Board of Directors Appointed by Reporting Entity </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A_documentation_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitiative Information, Number of Members of Board of Directors Appointed by Reporting Entity </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:to="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity_9A4FAD273F160E7C478FCEBF49ECEE1A" xlink:type="arc"/>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414_terseLabel_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Percent of board of directors appointed by reporting entity </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414_label_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Percent of Board of Directors Appointed By Reporting Entity </link:label>
<link:label id="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414_documentation_en-US" xlink:label="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Percent of Board of Directors Appointed By Reporting Entity </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity" xlink:label="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:to="lab_opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity_4F8680397CB0CD4D7D9CCEBF49EC8414" xlink:type="arc"/>
<link:label id="lab_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0_terseLabel_en-US" xlink:label="lab_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued for takeover </link:label>
<link:label id="lab_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0_label_en-US" xlink:label="lab_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0" xlink:to="lab_us-gaap_SharesIssued_9F55906A97FA573E610BCEBF49ECD1D0" xlink:type="arc"/>
<link:label id="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B_terseLabel_en-US" xlink:label="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage by shareholder </link:label>
<link:label id="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B_label_en-US" xlink:label="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Ownership Percentage by Shareholder </link:label>
<link:label id="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B_documentation_en-US" xlink:label="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Ownership Percentage by Shareholder </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OwnershipPercentagebyShareholder" xlink:label="loc_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:to="lab_opk_OwnershipPercentagebyShareholder_166B5819E4C412DA822CCEBF49EC200B" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA_terseLabel_en-US" xlink:label="lab_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain on deconsolidation of SciVac </link:label>
<link:label id="lab_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA_label_en-US" xlink:label="lab_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deconsolidation, Gain (Loss), Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeconsolidationGainOrLossAmount" xlink:label="loc_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA" xlink:to="lab_us-gaap_DeconsolidationGainOrLossAmount_7FB8803F099A7B37C640CEBF49ECB9CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7_terseLabel_en-US" xlink:label="lab_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of retained interest </link:label>
<link:label id="lab_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7_label_en-US" xlink:label="lab_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retained Interest, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedInterestFairValueDisclosure" xlink:label="loc_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7" xlink:to="lab_us-gaap_RetainedInterestFairValueDisclosure_04D01D724485B27D8CA8CEBF49EC87F7" xlink:type="arc"/>
<link:label id="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574_terseLabel_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash contribution </link:label>
<link:label id="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574_label_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Cash Contribution </link:label>
<link:label id="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574_documentation_en-US" xlink:label="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Cash Contribution </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_VariableInterestEntityCashContribution" xlink:label="loc_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:to="lab_opk_VariableInterestEntityCashContribution_68086C09818B4034218ACEBF49EC0574" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Exchange ratio </link:label>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825_label_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Exchange Ratio </link:label>
<link:label id="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Exchange Ratio </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio" xlink:label="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:to="lab_opk_BusinessAcquisitionEquityInterestIssuedorIssuableExchangeRatio_C955D880826DACD92219CEC4C10A4825" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock received </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Number of Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_36558D56408D187080F0CEC5519881BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Voting percent </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Percentage of Voting Interests Acquired </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285" xlink:to="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_F098067E856CC75F6999CEC1E0A3C285" xlink:type="arc"/>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3_terseLabel_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of diluted shares outstanding </link:label>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3_label_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Percentage of Diluted Shares Outstanding </link:label>
<link:label id="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3_documentation_en-US" xlink:label="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Percentage of Diluted Shares Outstanding </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding" xlink:label="loc_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:to="lab_opk_BusinessAcquisitionPercentageofDilutedSharesOutstanding_47B728DC0C6E69D0E54DCEC830BB2AF3" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingAbstract_02E3C2D29E0C5D9C9C866BE7336D3F6B_label_en-US" xlink:label="lab_us-gaap_SegmentReportingAbstract_BBB3726BBA165849A89CBC0718DEBC58" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_BBB3726BBA165849A89CBC0718DEBC58" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingAbstract_BBB3726BBA165849A89CBC0718DEBC58" xlink:to="lab_us-gaap_SegmentReportingAbstract_BBB3726BBA165849A89CBC0718DEBC58" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_E0328C3B76C881148EE56BE7336D9C78_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_986C72D6AA145150900187064F628085" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Information regarding our geographic activities </link:label>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_E0328C3B76C881148EE56BE7336D9C78_label_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_986C72D6AA145150900187064F628085" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_986C72D6AA145150900187064F628085" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_986C72D6AA145150900187064F628085" xlink:to="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_986C72D6AA145150900187064F628085" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_DA851DC127043A5572BC6BE734D950D3_verboseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_6A6F08CB156D53F5A6DF934B114407BF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of Notes: </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_DA851DC127043A5572BC6BE734D950D3_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_6A6F08CB156D53F5A6DF934B114407BF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Fair Value of Embedded Derivative, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_6A6F08CB156D53F5A6DF934B114407BF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_6A6F08CB156D53F5A6DF934B114407BF" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeNetAbstract_6A6F08CB156D53F5A6DF934B114407BF" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_4F4CAD0FD9A0A279F9206BE734D9D3D4_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures_028F1AA5147853F9A2ED2AD473CDF9EA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> With the embedded derivatives </link:label>
<link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_4F4CAD0FD9A0A279F9206BE734D9D3D4_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures_028F1AA5147853F9A2ED2AD473CDF9EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_028F1AA5147853F9A2ED2AD473CDF9EA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtFairValueDisclosures_028F1AA5147853F9A2ED2AD473CDF9EA" xlink:to="lab_us-gaap_ConvertibleDebtFairValueDisclosures_028F1AA5147853F9A2ED2AD473CDF9EA" xlink:type="arc"/>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_1EB6053DB5C0E483A4CB6BE734D90DEC_verboseLabel_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Without the embedded derivatives </link:label>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_1EB6053DB5C0E483A4CB6BE734D90DEC_label_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures, Excluding Embedded Derivative </link:label>
<link:label id="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_1EB6053DB5C0E483A4CB6BE734D90DEC_documentation_en-US" xlink:label="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Convertible Debt, Fair Value Disclosures, Excluding Embedded Derivative. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" xlink:label="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:to="lab_opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative_93B00D2B806550E1B9E6DD7B529F0AA4" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_92B42C9F6F37BAE969E56BE734D9ED4E_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_82D7B54F1016583EA1CC4B9719CED84E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Estimated fair value of the embedded derivatives </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_82D7B54F1016583EA1CC4B9719CED84E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_82D7B54F1016583EA1CC4B9719CED84E" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_82D7B54F1016583EA1CC4B9719CED84E" xlink:type="arc"/>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_EAD5AE12C951D10297526BE734F77332_verboseLabel_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Composition of certain financial statement captions </link:label>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_EAD5AE12C951D10297526BE734F77332_label_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Composition of Certain Financial Statement Captions [Table Text Block] </link:label>
<link:label id="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_EAD5AE12C951D10297526BE734F77332_documentation_en-US" xlink:label="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Composition of certain financial statement captions. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" xlink:label="loc_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:to="lab_opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock_CB57CA9D14F55422A772D058AF47F69E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_92EE302653A887288C2C6BE734F78277_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_FEBB43B4A5A65EAEA49D3A1FC250353C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of goodwill </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_92EE302653A887288C2C6BE734F78277_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_FEBB43B4A5A65EAEA49D3A1FC250353C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock" xlink:label="loc_us-gaap_ScheduleOfGoodwillTextBlock_FEBB43B4A5A65EAEA49D3A1FC250353C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfGoodwillTextBlock_FEBB43B4A5A65EAEA49D3A1FC250353C" xlink:to="lab_us-gaap_ScheduleOfGoodwillTextBlock_FEBB43B4A5A65EAEA49D3A1FC250353C" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeTable_346074F542277FD532E0BB4CF5034701_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeTable_959A48F0232B51D4998110203BAE8023" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative [Table] </link:label>
<link:label id="lab_us-gaap_DerivativeTable_346074F542277FD532E0BB4CF5034701_label_en-US" xlink:label="lab_us-gaap_DerivativeTable_959A48F0232B51D4998110203BAE8023" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_959A48F0232B51D4998110203BAE8023" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeTable_959A48F0232B51D4998110203BAE8023" xlink:to="lab_us-gaap_DerivativeTable_959A48F0232B51D4998110203BAE8023" xlink:type="arc"/>
<link:label id="lab_us-gaap_HedgingDesignationAxis_3F6518D5E70B6EF78620BB4CF5032DC0_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_4D94773DE98652778787DEC079C10F05" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationAxis_3F6518D5E70B6EF78620BB4CF5032DC0_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_4D94773DE98652778787DEC079C10F05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_4D94773DE98652778787DEC079C10F05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationAxis_4D94773DE98652778787DEC079C10F05" xlink:to="lab_us-gaap_HedgingDesignationAxis_4D94773DE98652778787DEC079C10F05" xlink:type="arc"/>
<link:label id="lab_us-gaap_HedgingDesignationDomain_FDBA355C927C77F17F56BB4CF5043031_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_B2DDE1642A7C504DB0FB22ABE1D74043" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationDomain_FDBA355C927C77F17F56BB4CF5043031_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_B2DDE1642A7C504DB0FB22ABE1D74043" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_B2DDE1642A7C504DB0FB22ABE1D74043" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain_B2DDE1642A7C504DB0FB22ABE1D74043" xlink:to="lab_us-gaap_HedgingDesignationDomain_B2DDE1642A7C504DB0FB22ABE1D74043" xlink:type="arc"/>
<link:label id="lab_us-gaap_NondesignatedMember_E76A0225FA7A51CEAE62BB4CF504CE30_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember_9C3CE03EDE055BCFA9C95057C8984BCA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument </link:label>
<link:label id="lab_us-gaap_NondesignatedMember_E76A0225FA7A51CEAE62BB4CF504CE30_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember_9C3CE03EDE055BCFA9C95057C8984BCA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_9C3CE03EDE055BCFA9C95057C8984BCA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember_9C3CE03EDE055BCFA9C95057C8984BCA" xlink:to="lab_us-gaap_NondesignatedMember_9C3CE03EDE055BCFA9C95057C8984BCA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_D11CAD428EE777E58652BB4CF504395F_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_FB04DFA6EE355975942D79823F9AF0B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instrument Risk [Axis] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_D11CAD428EE777E58652BB4CF504395F_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_FB04DFA6EE355975942D79823F9AF0B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_FB04DFA6EE355975942D79823F9AF0B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_FB04DFA6EE355975942D79823F9AF0B7" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis_FB04DFA6EE355975942D79823F9AF0B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeContractTypeDomain_1EE3FF990D83F3D661E9BB4CF5049CED_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_DFDAA4C450C053ED99AA4FD512CC4D08" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Contract Type [Domain] </link:label>
<link:label id="lab_us-gaap_DerivativeContractTypeDomain_1EE3FF990D83F3D661E9BB4CF5049CED_label_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_DFDAA4C450C053ED99AA4FD512CC4D08" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Contract [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_DFDAA4C450C053ED99AA4FD512CC4D08" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_DFDAA4C450C053ED99AA4FD512CC4D08" xlink:to="lab_us-gaap_DerivativeContractTypeDomain_DFDAA4C450C053ED99AA4FD512CC4D08" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForwardContractsMember_58B51384404891CB267ABB4CF504759C_terseLabel_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_90573053ECD45CFA8B74EE88FFF44D2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Forward contracts </link:label>
<link:label id="lab_us-gaap_ForwardContractsMember_58B51384404891CB267ABB4CF504759C_label_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_90573053ECD45CFA8B74EE88FFF44D2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Forward Contracts [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_90573053ECD45CFA8B74EE88FFF44D2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForwardContractsMember_90573053ECD45CFA8B74EE88FFF44D2D" xlink:to="lab_us-gaap_ForwardContractsMember_90573053ECD45CFA8B74EE88FFF44D2D" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeByMaturityAxis_77B3B130BE5F9CD8C5CBBB4CF504CF3D_terseLabel_en-US" xlink:label="lab_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative, By Maturity [Axis] </link:label>
<link:label id="lab_opk_DerivativeByMaturityAxis_77B3B130BE5F9CD8C5CBBB4CF504CF3D_label_en-US" xlink:label="lab_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, By Maturity [Axis] </link:label>
<link:label id="lab_opk_DerivativeByMaturityAxis_77B3B130BE5F9CD8C5CBBB4CF504CF3D_documentation_en-US" xlink:label="lab_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Derivative, By Maturity [Axis] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeByMaturityAxis" xlink:label="loc_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:to="lab_opk_DerivativeByMaturityAxis_0DEFB72B16B459CA9C29BB3EC0C4368D" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeByMaturityDomain_1A374A9972EE7B4A9649BB4CF504DB2F_terseLabel_en-US" xlink:label="lab_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative, By Maturity [Domain] </link:label>
<link:label id="lab_opk_DerivativeByMaturityDomain_1A374A9972EE7B4A9649BB4CF504DB2F_label_en-US" xlink:label="lab_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, By Maturity [Domain] </link:label>
<link:label id="lab_opk_DerivativeByMaturityDomain_1A374A9972EE7B4A9649BB4CF504DB2F_documentation_en-US" xlink:label="lab_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> [Domain] for Derivative, By Maturity [Axis] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeByMaturityDomain" xlink:label="loc_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:to="lab_opk_DerivativeByMaturityDomain_386AE280600556E09ECB24CFA87A4967" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_CF68372AD26F660C1448BB4CF5040745_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 0 to 30 </link:label>
<link:label id="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_CF68372AD26F660C1448BB4CF5040745_label_en-US" xlink:label="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, Zero to Thirty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_CF68372AD26F660C1448BB4CF5040745_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> 0 to 30. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityZerotoThirtyDaysMember" xlink:label="loc_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:to="lab_opk_DerivativeMaturityZerotoThirtyDaysMember_2AD12E89D9885DA0A19285F0903EE887" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_9DBDB9BCDD05C5E64D1BBB4CF5046B11_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 31 to 60 </link:label>
<link:label id="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_9DBDB9BCDD05C5E64D1BBB4CF5046B11_label_en-US" xlink:label="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, Thirty One to Sixty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_9DBDB9BCDD05C5E64D1BBB4CF5046B11_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> 31 to 60. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityThirtyOnetoSixtyDaysMember" xlink:label="loc_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:to="lab_opk_DerivativeMaturityThirtyOnetoSixtyDaysMember_18DE9A72869356FAAEC5F49DFA2F3954" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_060071568D408AF7A3C3BB4CF504D24E_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 61 to 90 </link:label>
<link:label id="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_060071568D408AF7A3C3BB4CF504D24E_label_en-US" xlink:label="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, Sixty One to Ninety Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_060071568D408AF7A3C3BB4CF504D24E_documentation_en-US" xlink:label="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> 61 to 90. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturitySixtyOnetoNinetyDaysMember" xlink:label="loc_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:to="lab_opk_DerivativeMaturitySixtyOnetoNinetyDaysMember_714CBFAD12255C46AD50B98C57CA6A69" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_83F991CE9450396256CBBB4CF504E9AA_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 91 to 120 </link:label>
<link:label id="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_83F991CE9450396256CBBB4CF504E9AA_label_en-US" xlink:label="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, Ninety One to One Hundred Twenty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_83F991CE9450396256CBBB4CF504E9AA_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> 91 to 120. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember" xlink:label="loc_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:to="lab_opk_DerivativeMaturityNinetyOnetoOneHundredTwentyDaysMember_957482330D295F97AE607CA84A91289E" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_676E9486C0C1D0543171BB4CF50413A0_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 121 to 180 </link:label>
<link:label id="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_676E9486C0C1D0543171BB4CF50413A0_label_en-US" xlink:label="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, One Hundred Twenty One to One Hundred Eighty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_676E9486C0C1D0543171BB4CF50413A0_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> 121 to 180. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember" xlink:label="loc_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:to="lab_opk_DerivativeMaturityOneHundredTwentyOnetoOneHundredEightyDaysMember_74A198A61294523EB19946E40F53A818" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_8ACA9918205C30EA88D9BB4CF504CBAD_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> More than 120 </link:label>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_8ACA9918205C30EA88D9BB4CF504CBAD_label_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, More than One Hundred Twenty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_8ACA9918205C30EA88D9BB4CF504CBAD_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Derivative Maturity, More than One Hundred Twenty Days [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember" xlink:label="loc_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:to="lab_opk_DerivativeMaturityMorethanOneHundredTwentyDaysMember_D0A9EFEC6A935940A18F6575B86243B7" xlink:type="arc"/>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_9088C361141419C91FA5BB4CF5051DB1_terseLabel_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> More than 180 </link:label>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_9088C361141419C91FA5BB4CF5051DB1_label_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Maturity More than One Hundred Eighty Days [Member] </link:label>
<link:label id="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_9088C361141419C91FA5BB4CF5051DB1_documentation_en-US" xlink:label="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> More than 180. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DerivativeMaturityMorethanOneHundredEightyDaysMember" xlink:label="loc_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:to="lab_opk_DerivativeMaturityMorethanOneHundredEightyDaysMember_5F0556D5AF825B29A9F772A984ADE8B0" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLineItems_C68DA77B6992616FD127BB4CF505FCAA_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_4E323496F425521C95590633747CB90D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativeLineItems_C68DA77B6992616FD127BB4CF505FCAA_label_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_4E323496F425521C95590633747CB90D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_4E323496F425521C95590633747CB90D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLineItems_4E323496F425521C95590633747CB90D" xlink:to="lab_us-gaap_DerivativeLineItems_4E323496F425521C95590633747CB90D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_B80A6B7C2EFD6E80C6C1BB4CF505FE5E_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_8A67C62EAF1B5F4CB5D3F7E66EEF72B2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contract value </link:label>
<link:label id="lab_us-gaap_DerivativeLiabilityNotionalAmount_B80A6B7C2EFD6E80C6C1BB4CF505FE5E_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityNotionalAmount_8A67C62EAF1B5F4CB5D3F7E66EEF72B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Notional Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_8A67C62EAF1B5F4CB5D3F7E66EEF72B2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityNotionalAmount_8A67C62EAF1B5F4CB5D3F7E66EEF72B2" xlink:to="lab_us-gaap_DerivativeLiabilityNotionalAmount_8A67C62EAF1B5F4CB5D3F7E66EEF72B2" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BA871C9CB5542371418CBB4CF5067823_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_75C87351EF1A59E0BB21849CCDE6D772" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BA871C9CB5542371418CBB4CF5067823_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_75C87351EF1A59E0BB21849CCDE6D772" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Gross Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_75C87351EF1A59E0BB21849CCDE6D772" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_75C87351EF1A59E0BB21849CCDE6D772" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_75C87351EF1A59E0BB21849CCDE6D772" xlink:type="arc"/>
<link:label id="lab_us-gaap_UnrealizedGainLossOnDerivatives_8045F5F5D51FEEEC1347BB4CF506C303_terseLabel_en-US" xlink:label="lab_us-gaap_UnrealizedGainLossOnDerivatives_3ED3AF289B5C50F9B19EC7A6D6012F0E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Effect on income (loss) </link:label>
<link:label id="lab_us-gaap_UnrealizedGainLossOnDerivatives_8045F5F5D51FEEEC1347BB4CF506C303_label_en-US" xlink:label="lab_us-gaap_UnrealizedGainLossOnDerivatives_3ED3AF289B5C50F9B19EC7A6D6012F0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Unrealized Gain (Loss) on Derivatives </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrealizedGainLossOnDerivatives" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_3ED3AF289B5C50F9B19EC7A6D6012F0E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrealizedGainLossOnDerivatives_3ED3AF289B5C50F9B19EC7A6D6012F0E" xlink:to="lab_us-gaap_UnrealizedGainLossOnDerivatives_3ED3AF289B5C50F9B19EC7A6D6012F0E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLowerRemainingMaturityRange1_850F82324CF4C396CD3CBB4CF50677DC_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLowerRemainingMaturityRange1_43562A7D40E35A93AD7E859DD319BC9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contract days until maturity, lower range </link:label>
<link:label id="lab_us-gaap_DerivativeLowerRemainingMaturityRange1_850F82324CF4C396CD3CBB4CF50677DC_label_en-US" xlink:label="lab_us-gaap_DerivativeLowerRemainingMaturityRange1_43562A7D40E35A93AD7E859DD319BC9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Lower Remaining Maturity Range </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLowerRemainingMaturityRange1" xlink:label="loc_us-gaap_DerivativeLowerRemainingMaturityRange1_43562A7D40E35A93AD7E859DD319BC9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLowerRemainingMaturityRange1_43562A7D40E35A93AD7E859DD319BC9F" xlink:to="lab_us-gaap_DerivativeLowerRemainingMaturityRange1_43562A7D40E35A93AD7E859DD319BC9F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeHigherRemainingMaturityRange1_270E153CFAB27667C066BB4CF506D756_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeHigherRemainingMaturityRange1_E9E820A24D8F5871BADBAD8491B0BF4E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contract days until maturity, higher range </link:label>
<link:label id="lab_us-gaap_DerivativeHigherRemainingMaturityRange1_270E153CFAB27667C066BB4CF506D756_label_en-US" xlink:label="lab_us-gaap_DerivativeHigherRemainingMaturityRange1_E9E820A24D8F5871BADBAD8491B0BF4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Higher Remaining Maturity Range </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeHigherRemainingMaturityRange1" xlink:label="loc_us-gaap_DerivativeHigherRemainingMaturityRange1_E9E820A24D8F5871BADBAD8491B0BF4E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeHigherRemainingMaturityRange1_E9E820A24D8F5871BADBAD8491B0BF4E" xlink:to="lab_us-gaap_DerivativeHigherRemainingMaturityRange1_E9E820A24D8F5871BADBAD8491B0BF4E" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_AFD995FAA3D2E2FEE9F76BE733936DE6_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract_CC7E939560CE5789A9C75CD331414C86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Cash Flows [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_CC7E939560CE5789A9C75CD331414C86" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_CC7E939560CE5789A9C75CD331414C86" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract_CC7E939560CE5789A9C75CD331414C86" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementTable_8991FFE18C0C2E42BB056BE73393251F_terseLabel_en-US" xlink:label="lab_us-gaap_StatementTable_D51551389433511892D9C4CA50ED520B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Table] </link:label>
<link:label id="lab_us-gaap_StatementTable_8991FFE18C0C2E42BB056BE73393251F_label_en-US" xlink:label="lab_us-gaap_StatementTable_D51551389433511892D9C4CA50ED520B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_D51551389433511892D9C4CA50ED520B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementTable_D51551389433511892D9C4CA50ED520B" xlink:to="lab_us-gaap_StatementTable_D51551389433511892D9C4CA50ED520B" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementLineItems_C2D5650715F285FD43DB6BE733947EED_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems_65CF6E23DAD451ECAFDD0DAB76E5AD9A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:label id="lab_us-gaap_StatementLineItems_C2D5650715F285FD43DB6BE733947EED_label_en-US" xlink:label="lab_us-gaap_StatementLineItems_65CF6E23DAD451ECAFDD0DAB76E5AD9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_65CF6E23DAD451ECAFDD0DAB76E5AD9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementLineItems_65CF6E23DAD451ECAFDD0DAB76E5AD9A" xlink:to="lab_us-gaap_StatementLineItems_65CF6E23DAD451ECAFDD0DAB76E5AD9A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_5C476691D704606C4E3A6BE733946025_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_B9D8A85F594458A884F4610726DF3AD5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Convertible senior notes interest rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_5C476691D704606C4E3A6BE733946025_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_B9D8A85F594458A884F4610726DF3AD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Interest Rate, Stated Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_B9D8A85F594458A884F4610726DF3AD5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_B9D8A85F594458A884F4610726DF3AD5" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_B9D8A85F594458A884F4610726DF3AD5" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_DAC8D77987775396D3926BE734E68212_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_BC4B584DD1415EC48C1506E958C75D5D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> FAIR VALUE MEASUREMENTS </link:label>
<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_DAC8D77987775396D3926BE734E68212_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_BC4B584DD1415EC48C1506E958C75D5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_BC4B584DD1415EC48C1506E958C75D5D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresTextBlock_BC4B584DD1415EC48C1506E958C75D5D" xlink:to="lab_us-gaap_FairValueDisclosuresTextBlock_BC4B584DD1415EC48C1506E958C75D5D" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockMember_07A48F15F4A2A6EE7F008679C8461DF1_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_07A48F15F4A2A6EE7F008679C8461DF1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_07A48F15F4A2A6EE7F008679C8461DF1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_07A48F15F4A2A6EE7F008679C8461DF1" xlink:to="lab_us-gaap_CommonStockMember_07A48F15F4A2A6EE7F008679C8461DF1" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash paid at closing date </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Businesses, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesGross_955C056A04BAD096B1F88679C84C2715" xlink:type="arc"/>
<link:label id="lab_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4_verboseLabel_en-US" xlink:label="lab_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Stock price </link:label>
<link:label id="lab_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4_label_en-US" xlink:label="lab_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4" xlink:to="lab_us-gaap_SharePrice_08FC9FE350E2DD10AB8D8679C84C18C4" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquired entity share price </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Share Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionSharePrice" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92" xlink:to="lab_us-gaap_BusinessAcquisitionSharePrice_88AA448A05FF81CB36138679C84CBF92" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock value </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Value Assigned </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_2CC6307840CCA30CF2228679C84D0330" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consideration transferred </link:label>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF" xlink:to="lab_us-gaap_BusinessCombinationConsiderationTransferred1_6FA0C122C2EFA43F3B588679C84CA1EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_8D6EB861650768393A92BB4CF4E33AE6_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_534D3869DE525D8793C0788ECC566B0D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) by Hedging Relationship, by Income Statement Location, by Derivative Instrument Risk [Table] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_8D6EB861650768393A92BB4CF4E33AE6_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_534D3869DE525D8793C0788ECC566B0D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_534D3869DE525D8793C0788ECC566B0D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_534D3869DE525D8793C0788ECC566B0D" xlink:to="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_534D3869DE525D8793C0788ECC566B0D" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockOptionMember_5EC0352BDD687DE0A4F7BB4CF4E3F45E_verboseLabel_en-US" xlink:label="lab_us-gaap_StockOptionMember_C50C8F614D6E551A80DD353FE0D61D9A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common stock options/warrants </link:label>
<link:label id="lab_us-gaap_StockOptionMember_5EC0352BDD687DE0A4F7BB4CF4E3F45E_label_en-US" xlink:label="lab_us-gaap_StockOptionMember_C50C8F614D6E551A80DD353FE0D61D9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Option [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_us-gaap_StockOptionMember_C50C8F614D6E551A80DD353FE0D61D9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockOptionMember_C50C8F614D6E551A80DD353FE0D61D9A" xlink:to="lab_us-gaap_StockOptionMember_C50C8F614D6E551A80DD353FE0D61D9A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_7A8E58CAE01735757229BB4CF4E34F6B_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_256E886C1AD655CA9D7218BCD173A007" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_7A8E58CAE01735757229BB4CF4E34F6B_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_256E886C1AD655CA9D7218BCD173A007" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_256E886C1AD655CA9D7218BCD173A007" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_256E886C1AD655CA9D7218BCD173A007" xlink:to="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_256E886C1AD655CA9D7218BCD173A007" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_A7CA5B038E67AA2C9BC4BB4CF4E36FFC_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_DBC717217CF55D39A446F29C92A4D189" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total </link:label>
<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_A7CA5B038E67AA2C9BC4BB4CF4E36FFC_label_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_DBC717217CF55D39A446F29C92A4D189" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Gain (Loss) on Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_DBC717217CF55D39A446F29C92A4D189" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_DBC717217CF55D39A446F29C92A4D189" xlink:to="lab_us-gaap_DerivativeGainLossOnDerivativeNet_DBC717217CF55D39A446F29C92A4D189" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_4348A765B016A63872D1D556C0D9043B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C84DE1EFFB27516C8F4EC50E3ADC4B5D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_4348A765B016A63872D1D556C0D9043B_label_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C84DE1EFFB27516C8F4EC50E3ADC4B5D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C84DE1EFFB27516C8F4EC50E3ADC4B5D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C84DE1EFFB27516C8F4EC50E3ADC4B5D" xlink:to="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_C84DE1EFFB27516C8F4EC50E3ADC4B5D" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_32F7A69575DA5892851FD556C0D9715E_verboseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_0038426FC6EC5CC6AE164DD565569448" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_32F7A69575DA5892851FD556C0D9715E_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_0038426FC6EC5CC6AE164DD565569448" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative Financial Instruments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_0038426FC6EC5CC6AE164DD565569448" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_0038426FC6EC5CC6AE164DD565569448" xlink:to="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_0038426FC6EC5CC6AE164DD565569448" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentsMember_A59B4234338DE3DC7E95D556C0D9F9FD_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsMember_E341D9F207BA59F98CEB8CAB91654FDA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments, net </link:label>
<link:label id="lab_us-gaap_InvestmentsMember_A59B4234338DE3DC7E95D556C0D9F9FD_label_en-US" xlink:label="lab_us-gaap_InvestmentsMember_E341D9F207BA59F98CEB8CAB91654FDA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentsMember" xlink:label="loc_us-gaap_InvestmentsMember_E341D9F207BA59F98CEB8CAB91654FDA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentsMember_E341D9F207BA59F98CEB8CAB91654FDA" xlink:to="lab_us-gaap_InvestmentsMember_E341D9F207BA59F98CEB8CAB91654FDA" xlink:type="arc"/>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_46817DB78C127B9BA85DD556C0D981CF_terseLabel_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, net of discount and estimated fair value of embedded derivatives </link:label>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_46817DB78C127B9BA85DD556C0D981CF_label_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Three Percent Convertible, Senior Notes, Net of Discount and Estimated Fair Value of Embedded Derivatives [Member] </link:label>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_46817DB78C127B9BA85DD556C0D981CF_documentation_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Three Percent Convertible, Senior Notes, Net of Discount and Estimated Fair Value of Embedded Derivatives [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" xlink:label="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:to="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_5B3BDA705E285E22AF511FC12E82F5D3" xlink:type="arc"/>
<link:label id="lab_opk_LongtermDebtCurrentMaturitiesMember_665B2E7D60F062742E61D556C0DA2B9F_terseLabel_en-US" xlink:label="lab_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized gains on forward contracts are recorded in Prepaid expenses and other current assets. Unrealized losses on forward contracts are recorded in Accrued expenses. </link:label>
<link:label id="lab_opk_LongtermDebtCurrentMaturitiesMember_665B2E7D60F062742E61D556C0DA2B9F_label_en-US" xlink:label="lab_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Current Maturities [Member] </link:label>
<link:label id="lab_opk_LongtermDebtCurrentMaturitiesMember_665B2E7D60F062742E61D556C0DA2B9F_documentation_en-US" xlink:label="lab_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Current Maturities [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LongtermDebtCurrentMaturitiesMember" xlink:label="loc_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:to="lab_opk_LongtermDebtCurrentMaturitiesMember_92A337F1833C5DE0BA2CF8DFAA78EEEB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_AFC097A61677D9E01525D556C0DA1A43_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_4F66A1F4B9C053038AEFB554F8B4C311" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_AFC097A61677D9E01525D556C0DA1A43_label_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_4F66A1F4B9C053038AEFB554F8B4C311" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_4F66A1F4B9C053038AEFB554F8B4C311" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_4F66A1F4B9C053038AEFB554F8B4C311" xlink:to="lab_us-gaap_DerivativesFairValueLineItems_4F66A1F4B9C053038AEFB554F8B4C311" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_77146E2666A2AA90A320D556C0DAA316_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_7672678D446B56B1B295C94752B57D7A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative asset, fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_77146E2666A2AA90A320D556C0DAA316_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_7672678D446B56B1B295C94752B57D7A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Asset, Fair Value, Gross Asset </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_7672678D446B56B1B295C94752B57D7A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_7672678D446B56B1B295C94752B57D7A" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_7672678D446B56B1B295C94752B57D7A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_893B9A22145AEDFA3C12D556C0DA865B_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4C7C47BCC82C5CBA8155545C76408326" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative liability, fair value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4C7C47BCC82C5CBA8155545C76408326" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4C7C47BCC82C5CBA8155545C76408326" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_4C7C47BCC82C5CBA8155545C76408326" xlink:type="arc"/>
<link:label id="lab_opk_DocumentAndEntityInformationAbstract_0C3F8BF1818A9499C0A26BE73428CCBA_label_en-US" xlink:label="lab_opk_DocumentAndEntityInformationAbstract_E0A76C199B365AE4BF499FC4C9AC74A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document and Entity Information [Abstract] </link:label>
<link:label id="lab_opk_DocumentAndEntityInformationAbstract_0C3F8BF1818A9499C0A26BE73428CCBA_documentation_en-US" xlink:label="lab_opk_DocumentAndEntityInformationAbstract_E0A76C199B365AE4BF499FC4C9AC74A4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Document and Entity Information [Abstract] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DocumentAndEntityInformationAbstract" xlink:label="loc_opk_DocumentAndEntityInformationAbstract_E0A76C199B365AE4BF499FC4C9AC74A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DocumentAndEntityInformationAbstract_E0A76C199B365AE4BF499FC4C9AC74A4" xlink:to="lab_opk_DocumentAndEntityInformationAbstract_E0A76C199B365AE4BF499FC4C9AC74A4" xlink:type="arc"/>
<link:label id="lab_dei_EntityRegistrantName_1EEE480376973AFD5BAA6BE734288E85_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName_6790A86AD10B5B9A820DBEC7365AF433" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Registrant Name </link:label>
<link:label id="lab_dei_EntityRegistrantName_1EEE480376973AFD5BAA6BE734288E85_label_en-US" xlink:label="lab_dei_EntityRegistrantName_6790A86AD10B5B9A820DBEC7365AF433" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Registrant Name </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_6790A86AD10B5B9A820DBEC7365AF433" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName_6790A86AD10B5B9A820DBEC7365AF433" xlink:to="lab_dei_EntityRegistrantName_6790A86AD10B5B9A820DBEC7365AF433" xlink:type="arc"/>
<link:label id="lab_dei_EntityCentralIndexKey_CB71906CF08B746B36336BE734286B91_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey_E26818484AB65B239AEB8A6B337AECF1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Central Index Key </link:label>
<link:label id="lab_dei_EntityCentralIndexKey_CB71906CF08B746B36336BE734286B91_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey_E26818484AB65B239AEB8A6B337AECF1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Central Index Key </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_E26818484AB65B239AEB8A6B337AECF1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey_E26818484AB65B239AEB8A6B337AECF1" xlink:to="lab_dei_EntityCentralIndexKey_E26818484AB65B239AEB8A6B337AECF1" xlink:type="arc"/>
<link:label id="lab_dei_DocumentType_A1EB49A5556A75C97EC46BE73428B4D6_terseLabel_en-US" xlink:label="lab_dei_DocumentType_30BDE893324B51599160B525CB295E88" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Type </link:label>
<link:label id="lab_dei_DocumentType_A1EB49A5556A75C97EC46BE73428B4D6_label_en-US" xlink:label="lab_dei_DocumentType_30BDE893324B51599160B525CB295E88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Type </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_30BDE893324B51599160B525CB295E88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType_30BDE893324B51599160B525CB295E88" xlink:to="lab_dei_DocumentType_30BDE893324B51599160B525CB295E88" xlink:type="arc"/>
<link:label id="lab_dei_DocumentPeriodEndDate_7641AE4EA69D0E2D2B0E6BE734288964_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_2792FE944A07570EB45DD318F181B187" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Period End Date </link:label>
<link:label id="lab_dei_DocumentPeriodEndDate_7641AE4EA69D0E2D2B0E6BE734288964_label_en-US" xlink:label="lab_dei_DocumentPeriodEndDate_2792FE944A07570EB45DD318F181B187" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Period End Date </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_2792FE944A07570EB45DD318F181B187" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentPeriodEndDate_2792FE944A07570EB45DD318F181B187" xlink:to="lab_dei_DocumentPeriodEndDate_2792FE944A07570EB45DD318F181B187" xlink:type="arc"/>
<link:label id="lab_dei_AmendmentFlag_FFD8A693F443D6E322BF6BE73428C0C0_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag_4155FDA38BA35B5F88792D196DF7D30D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amendment Flag </link:label>
<link:label id="lab_dei_AmendmentFlag_FFD8A693F443D6E322BF6BE73428C0C0_label_en-US" xlink:label="lab_dei_AmendmentFlag_4155FDA38BA35B5F88792D196DF7D30D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amendment Flag </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_4155FDA38BA35B5F88792D196DF7D30D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag_4155FDA38BA35B5F88792D196DF7D30D" xlink:to="lab_dei_AmendmentFlag_4155FDA38BA35B5F88792D196DF7D30D" xlink:type="arc"/>
<link:label id="lab_dei_DocumentFiscalYearFocus_23BEB2AEE1BB120CFF3A6BE734299EC9_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_DA2484F331435BC5B0915AEDFD018FDF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Fiscal Year Focus </link:label>
<link:label id="lab_dei_DocumentFiscalYearFocus_23BEB2AEE1BB120CFF3A6BE734299EC9_label_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus_DA2484F331435BC5B0915AEDFD018FDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Fiscal Year Focus </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_DA2484F331435BC5B0915AEDFD018FDF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalYearFocus_DA2484F331435BC5B0915AEDFD018FDF" xlink:to="lab_dei_DocumentFiscalYearFocus_DA2484F331435BC5B0915AEDFD018FDF" xlink:type="arc"/>
<link:label id="lab_dei_DocumentFiscalPeriodFocus_831A3510B7B700302F536BE7342963AF_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_51D4859EF32456C7982773BAA06C7E66" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Document Fiscal Period Focus </link:label>
<link:label id="lab_dei_DocumentFiscalPeriodFocus_831A3510B7B700302F536BE7342963AF_label_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus_51D4859EF32456C7982773BAA06C7E66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document Fiscal Period Focus </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_51D4859EF32456C7982773BAA06C7E66" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalPeriodFocus_51D4859EF32456C7982773BAA06C7E66" xlink:to="lab_dei_DocumentFiscalPeriodFocus_51D4859EF32456C7982773BAA06C7E66" xlink:type="arc"/>
<link:label id="lab_dei_CurrentFiscalYearEndDate_700AADD2F49FF8DEBD3D6BE73429A1DA_terseLabel_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_B1F083B510C354809D421E310C5E3F08" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current Fiscal Year End Date </link:label>
<link:label id="lab_dei_CurrentFiscalYearEndDate_700AADD2F49FF8DEBD3D6BE73429A1DA_label_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate_B1F083B510C354809D421E310C5E3F08" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Current Fiscal Year End Date </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_B1F083B510C354809D421E310C5E3F08" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CurrentFiscalYearEndDate_B1F083B510C354809D421E310C5E3F08" xlink:to="lab_dei_CurrentFiscalYearEndDate_B1F083B510C354809D421E310C5E3F08" xlink:type="arc"/>
<link:label id="lab_dei_EntityFilerCategory_525911B0BC7B7F5D629C6BE734291708_terseLabel_en-US" xlink:label="lab_dei_EntityFilerCategory_080E9F894BBA5C23810783B6A6543F5A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Filer Category </link:label>
<link:label id="lab_dei_EntityFilerCategory_525911B0BC7B7F5D629C6BE734291708_label_en-US" xlink:label="lab_dei_EntityFilerCategory_080E9F894BBA5C23810783B6A6543F5A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Filer Category </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_080E9F894BBA5C23810783B6A6543F5A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityFilerCategory_080E9F894BBA5C23810783B6A6543F5A" xlink:to="lab_dei_EntityFilerCategory_080E9F894BBA5C23810783B6A6543F5A" xlink:type="arc"/>
<link:label id="lab_dei_EntityCommonStockSharesOutstanding_C5313F28D014DF562D786BE734296E42_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_257DEA2E9AED5FC3BDB5EC3D016BA2EC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:label id="lab_dei_EntityCommonStockSharesOutstanding_C5313F28D014DF562D786BE734296E42_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_257DEA2E9AED5FC3BDB5EC3D016BA2EC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_257DEA2E9AED5FC3BDB5EC3D016BA2EC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCommonStockSharesOutstanding_257DEA2E9AED5FC3BDB5EC3D016BA2EC" xlink:to="lab_dei_EntityCommonStockSharesOutstanding_257DEA2E9AED5FC3BDB5EC3D016BA2EC" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaximumMember_4E16D817F1C15346947FD371B8885A3B_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_4E16D817F1C15346947FD371B8885A3B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_4E16D817F1C15346947FD371B8885A3B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_4E16D817F1C15346947FD371B8885A3B" xlink:to="lab_us-gaap_MaximumMember_4E16D817F1C15346947FD371B8885A3B" xlink:type="arc"/>
<link:label id="lab_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387_terseLabel_en-US" xlink:label="lab_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Technology </link:label>
<link:label id="lab_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387_label_en-US" xlink:label="lab_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Technology Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TechnologyEquipmentMember" xlink:label="loc_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387" xlink:to="lab_us-gaap_TechnologyEquipmentMember_2D22257340F5AFBDF0A0D371B888A387" xlink:type="arc"/>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18_verboseLabel_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Internally developed software </link:label>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18_label_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Software and Software Development Costs [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18" xlink:to="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_A6D6F22EB072A5E926E6D371B888AA18" xlink:type="arc"/>
<link:label id="lab_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753_terseLabel_en-US" xlink:label="lab_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> IPR&D assets </link:label>
<link:label id="lab_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753_label_en-US" xlink:label="lab_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> In Process Research and Development [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753" xlink:to="lab_us-gaap_InProcessResearchAndDevelopmentMember_B34B3A0B0E5809367CD2D371B888D753" xlink:type="arc"/>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096_terseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expenses </link:label>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096_label_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expenses [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096" xlink:to="lab_us-gaap_SellingGeneralAndAdministrativeExpensesMember_B6794826620039005C03D371B8880096" xlink:type="arc"/>
<link:label id="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D_terseLabel_en-US" xlink:label="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inspiro </link:label>
<link:label id="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D_label_en-US" xlink:label="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inspiro Medical Ltd. [Member] </link:label>
<link:label id="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D_documentation_en-US" xlink:label="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Inspiro Medical Ltd. [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_InspiroMedicalLtd.Member" xlink:label="loc_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:to="lab_opk_InspiroMedicalLtd.Member_ECF5FA1884E428E3D399D371B888D67D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733_terseLabel_en-US" xlink:label="lab_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:label id="lab_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733_label_en-US" xlink:label="lab_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733" xlink:to="lab_us-gaap_Revenues_EC89E1220E392D915C2CD371B889A733" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:label id="lab_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7_label_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7" xlink:to="lab_us-gaap_NetIncomeLoss_CD262F447EDB9AC87EDAD371B8892BB7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1_terseLabel_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Useful life </link:label>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1_label_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Acquired Finite-lived Intangible Assets, Weighted Average Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1" xlink:to="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_CC94BB24ABD919526700D371B889A0C1" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisition related costs </link:label>
<link:label id="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Acquisition Related Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA" xlink:to="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_061E1C70E5706C052884D371B88902DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D253EB868094C7E5FE6FD371B889DF2E_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D253EB868094C7E5FE6FD371B889DF2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inspiro stock purchase agreement percent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D253EB868094C7E5FE6FD371B889DF2E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D253EB868094C7E5FE6FD371B889DF2E" xlink:to="lab_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_D253EB868094C7E5FE6FD371B889DF2E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentInProcess_A4B308AF370F180DB473D371B889DB7B_verboseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentInProcess_A4B308AF370F180DB473D371B889DB7B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> In-process research and development </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentInProcess" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_A4B308AF370F180DB473D371B889DB7B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentInProcess_A4B308AF370F180DB473D371B889DB7B" xlink:to="lab_us-gaap_ResearchAndDevelopmentInProcess_A4B308AF370F180DB473D371B889DB7B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_679FCF62C785179DDDCDE80FE10938DE_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable_61CB55C3AA455415BA55D0D192CBAF2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table] </link:label>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_679FCF62C785179DDDCDE80FE10938DE_label_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable_61CB55C3AA455415BA55D0D192CBAF2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61CB55C3AA455415BA55D0D192CBAF2E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61CB55C3AA455415BA55D0D192CBAF2E" xlink:to="lab_us-gaap_FairValueByBalanceSheetGroupingTable_61CB55C3AA455415BA55D0D192CBAF2E" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_21E22EBFBF4AEE52FE21E80FE10A049A_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_9D2D660E094559DF9D00797F4062402F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping, Disclosure Item Amounts [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_21E22EBFBF4AEE52FE21E80FE10A049A_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_9D2D660E094559DF9D00797F4062402F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Basis [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_9D2D660E094559DF9D00797F4062402F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_9D2D660E094559DF9D00797F4062402F" xlink:to="lab_us-gaap_FairValueByMeasurementBasisAxis_9D2D660E094559DF9D00797F4062402F" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_D5D8A4BFB8CDAC264EA7E80FE10AA5C9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_8D29EBE7089D52F489A241D64C3E5A46" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosure Item Amounts [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_D5D8A4BFB8CDAC264EA7E80FE10AA5C9_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_8D29EBE7089D52F489A241D64C3E5A46" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8D29EBE7089D52F489A241D64C3E5A46" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8D29EBE7089D52F489A241D64C3E5A46" xlink:to="lab_us-gaap_FairValueDisclosureItemAmountsDomain_8D29EBE7089D52F489A241D64C3E5A46" xlink:type="arc"/>
<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_EC2B87082591D41A3FB0E80FE10A9470_terseLabel_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_7BB1B71B85765784AEA0A52E36DAE337" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement </link:label>
<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_EC2B87082591D41A3FB0E80FE10A9470_label_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_7BB1B71B85765784AEA0A52E36DAE337" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_7BB1B71B85765784AEA0A52E36DAE337" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_7BB1B71B85765784AEA0A52E36DAE337" xlink:to="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_7BB1B71B85765784AEA0A52E36DAE337" xlink:type="arc"/>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_66D7469E883A412571E2E80FE10A2214_verboseLabel_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BCA4D85FD8105365996F165A6A076826" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Carrying Value </link:label>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_66D7469E883A412571E2E80FE10A2214_label_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BCA4D85FD8105365996F165A6A076826" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reported Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BCA4D85FD8105365996F165A6A076826" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BCA4D85FD8105365996F165A6A076826" xlink:to="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BCA4D85FD8105365996F165A6A076826" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_020AF970A8E171BE73AAE80FE10AE9C4_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F5A55AC97D005A9CA11AA295623DC83B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_020AF970A8E171BE73AAE80FE10AE9C4_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F5A55AC97D005A9CA11AA295623DC83B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F5A55AC97D005A9CA11AA295623DC83B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F5A55AC97D005A9CA11AA295623DC83B" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F5A55AC97D005A9CA11AA295623DC83B" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_115D250E10D27AC1A02FE80FE10AA193_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BA257F7604DD58F2A7889AE0F0E3C8E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements Fair Value Hierarchy [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_115D250E10D27AC1A02FE80FE10AA193_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BA257F7604DD58F2A7889AE0F0E3C8E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Hierarchy [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BA257F7604DD58F2A7889AE0F0E3C8E7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BA257F7604DD58F2A7889AE0F0E3C8E7" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BA257F7604DD58F2A7889AE0F0E3C8E7" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_981CFACE054DF5D656E0E80FE10A785F_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_7AADDB9FDA9056B2BC8E8D12021580C9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Level 1 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_981CFACE054DF5D656E0E80FE10A785F_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_7AADDB9FDA9056B2BC8E8D12021580C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 1 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_7AADDB9FDA9056B2BC8E8D12021580C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member_7AADDB9FDA9056B2BC8E8D12021580C9" xlink:to="lab_us-gaap_FairValueInputsLevel1Member_7AADDB9FDA9056B2BC8E8D12021580C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_D3A14195F5F8DDE8EB51E80FE10AF4F6_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_ADA46638D4BC52E68349FD95E609D6D1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Level 2 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_D3A14195F5F8DDE8EB51E80FE10AF4F6_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_ADA46638D4BC52E68349FD95E609D6D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 2 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_ADA46638D4BC52E68349FD95E609D6D1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member_ADA46638D4BC52E68349FD95E609D6D1" xlink:to="lab_us-gaap_FairValueInputsLevel2Member_ADA46638D4BC52E68349FD95E609D6D1" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_9BC1EFC8C6EB79419704E80FE10A7B9F_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_E50AD5BC96AA50B88FCDE14CFB33192E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Level 3 </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_9BC1EFC8C6EB79419704E80FE10A7B9F_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_E50AD5BC96AA50B88FCDE14CFB33192E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 3 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_E50AD5BC96AA50B88FCDE14CFB33192E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member_E50AD5BC96AA50B88FCDE14CFB33192E" xlink:to="lab_us-gaap_FairValueInputsLevel3Member_E50AD5BC96AA50B88FCDE14CFB33192E" xlink:type="arc"/>
<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_970CFDCBA7EE7F3E6153E80FE10A23B1_verboseLabel_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_A5084BAF081A5A1492DCC53E2C4101B2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_970CFDCBA7EE7F3E6153E80FE10A23B1_label_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_A5084BAF081A5A1492DCC53E2C4101B2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Payable, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NotesPayableFairValueDisclosure" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_A5084BAF081A5A1492DCC53E2C4101B2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesPayableFairValueDisclosure_A5084BAF081A5A1492DCC53E2C4101B2" xlink:to="lab_us-gaap_NotesPayableFairValueDisclosure_A5084BAF081A5A1492DCC53E2C4101B2" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsequentEventsTextBlock_1F5ADDEA146A2149D0426BE733811600_verboseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_D434BE93FE9D57F0B3D895F4D163C5B1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUBSEQUENT EVENTS </link:label>
<link:label id="lab_us-gaap_SubsequentEventsTextBlock_1F5ADDEA146A2149D0426BE733811600_label_en-US" xlink:label="lab_us-gaap_SubsequentEventsTextBlock_D434BE93FE9D57F0B3D895F4D163C5B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsequent Events [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_D434BE93FE9D57F0B3D895F4D163C5B1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventsTextBlock_D434BE93FE9D57F0B3D895F4D163C5B1" xlink:to="lab_us-gaap_SubsequentEventsTextBlock_D434BE93FE9D57F0B3D895F4D163C5B1" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountingPoliciesAbstract_B4E7D25A56DF11C000DC6BE7344E0B39_label_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract_0EBF798FE40E5D4DA044ED42F77FEB57" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_0EBF798FE40E5D4DA044ED42F77FEB57" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_0EBF798FE40E5D4DA044ED42F77FEB57" xlink:to="lab_us-gaap_AccountingPoliciesAbstract_0EBF798FE40E5D4DA044ED42F77FEB57" xlink:type="arc"/>
<link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_A63AF77766693C3FA3596BE7344E7F15_verboseLabel_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_8F25F7491168559CAA4119CC61F97A3F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES </link:label>
<link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_A63AF77766693C3FA3596BE7344E7F15_label_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_8F25F7491168559CAA4119CC61F97A3F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Significant Accounting Policies [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_8F25F7491168559CAA4119CC61F97A3F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SignificantAccountingPoliciesTextBlock_8F25F7491168559CAA4119CC61F97A3F" xlink:to="lab_us-gaap_SignificantAccountingPoliciesTextBlock_8F25F7491168559CAA4119CC61F97A3F" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9DFAB6E5045419BDDF2DEE015CA1B480_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9DFAB6E5045419BDDF2DEE015CA1B480" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Commitments and Contingencies Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9DFAB6E5045419BDDF2DEE015CA1B480" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9DFAB6E5045419BDDF2DEE015CA1B480" xlink:to="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9DFAB6E5045419BDDF2DEE015CA1B480" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_E5AE6B69AE721D59ADA6EE015CA1262D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesMember_F1E3ECA6DB7CEE0C87CAEE015CA28ED4_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_F1E3ECA6DB7CEE0C87CAEE015CA28ED4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_F1E3ECA6DB7CEE0C87CAEE015CA28ED4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesMember_F1E3ECA6DB7CEE0C87CAEE015CA28ED4" xlink:to="lab_us-gaap_AccruedLiabilitiesMember_F1E3ECA6DB7CEE0C87CAEE015CA28ED4" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Contingent Consideration [Line Items] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Contingent Consideration [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D" xlink:to="lab_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_F9BB3A3958E5763DB135EE015CA2597D" xlink:type="arc"/>
<link:label id="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495_terseLabel_en-US" xlink:label="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of claims included in post-payment audit </link:label>
<link:label id="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495_label_en-US" xlink:label="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Medicare Claims Included in Post-Payment Review Audit </link:label>
<link:label id="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495_documentation_en-US" xlink:label="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of Medicare Claims Included in Post-Payment Review Audit </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit" xlink:label="loc_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:to="lab_opk_NumberofMedicareClaimsIncludedinPostPaymentReviewAudit_30F86729A5287F640590EE015CA26495" xlink:type="arc"/>
<link:label id="lab_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE_terseLabel_en-US" xlink:label="lab_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed purchase provisions </link:label>
<link:label id="lab_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE_label_en-US" xlink:label="lab_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Purchase Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PurchaseObligation" xlink:label="loc_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE" xlink:to="lab_us-gaap_PurchaseObligation_DD55CB250FDE93F0A126EE015CA216FE" xlink:type="arc"/>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C_terseLabel_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C_label_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C_documentation_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Table] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:to="lab_opk_SummaryOfSignificantAccountingPoliciesTable_67C442D87F616D3A4902CE356516372C" xlink:type="arc"/>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1_label_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1" xlink:to="lab_us-gaap_TypeOfArrangementAxis_5C4D005938B2B64E08A5CE3565164EE1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832_terseLabel_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832_label_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832" xlink:to="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_B886E360DED465106635CE356516D832" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementProductAgreementMember" xlink:label="loc_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1" xlink:to="lab_us-gaap_CollaborativeArrangementProductAgreementMember_5A6EDBBF9DA54BEEC551CE3565165ED1" xlink:type="arc"/>
<link:label id="lab_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698_terseLabel_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:label id="lab_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698_label_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698" xlink:to="lab_us-gaap_CounterpartyNameAxis_0F39136D1550A1218DE1CE3565163698" xlink:type="arc"/>
<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5" xlink:to="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_DCE66AF8188545A08BBACE356516A1F5" xlink:type="arc"/>
<link:label id="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578_terseLabel_en-US" xlink:label="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pfizer </link:label>
<link:label id="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578_label_en-US" xlink:label="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pfizer [Member] </link:label>
<link:label id="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578_documentation_en-US" xlink:label="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pfizer [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PfizerMember" xlink:label="loc_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:to="lab_opk_PfizerMember_2C688195D57B71B83D85CE3565161578" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C6DF3DB99071C1E3479CE3565162E90" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_B1D9483767C5A40CF04ACE35651601CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0E3A3C2E15CAD224785BCE356516C3F5_terseLabel_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0E3A3C2E15CAD224785BCE356516C3F5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Software </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0E3A3C2E15CAD224785BCE356516C3F5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0E3A3C2E15CAD224785BCE356516C3F5" xlink:to="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0E3A3C2E15CAD224785BCE356516C3F5" xlink:type="arc"/>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4_terseLabel_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Machinery and equipment </link:label>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4_label_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Machinery and Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4" xlink:to="lab_us-gaap_MachineryAndEquipmentMember_1ABB3F0DD99EC8B7E4FFCE3565170CD4" xlink:type="arc"/>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659_terseLabel_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Furniture and fixtures </link:label>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659_label_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659" xlink:to="lab_us-gaap_FurnitureAndFixturesMember_1C6BD4CF83434E71115ECE356517A659" xlink:type="arc"/>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C_terseLabel_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Buildings and improvements </link:label>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C_label_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Building and Building Improvements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C" xlink:to="lab_us-gaap_BuildingAndBuildingImprovementsMember_BB9AB8535A5038A60B5BCE3565174D2C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5" xlink:to="lab_us-gaap_ConcentrationRiskByTypeAxis_D9E8120A2BF6B160C67ACE3565173FA5" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2" xlink:to="lab_us-gaap_ConcentrationRiskTypeDomain_EFB0D2352205D23F01E2CE3565177FB2" xlink:type="arc"/>
<link:label id="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1_terseLabel_en-US" xlink:label="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Medicare and Medicaid </link:label>
<link:label id="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1_label_en-US" xlink:label="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Medicare and Medicaid [Member] </link:label>
<link:label id="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1_documentation_en-US" xlink:label="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Medicare and Medicaid [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_MedicareandMedicaidMember" xlink:label="loc_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:to="lab_opk_MedicareandMedicaidMember_74D89AB44B680F02107FCE35651790D1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C" xlink:to="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_263D1D333410C47DD34CCE356517B12C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897" xlink:to="lab_us-gaap_ConcentrationRiskBenchmarkDomain_7716F00F3025903005F5CE356517D897" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sales Revenue </link:label>
<link:label id="lab_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE_label_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Services, Net [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueServicesNetMember" xlink:label="loc_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE" xlink:to="lab_us-gaap_SalesRevenueServicesNetMember_A1EB2EEEEE2F018C04F1CE3565175DFE" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts Receivable </link:label>
<link:label id="lab_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14" xlink:to="lab_us-gaap_AccountsReceivableMember_FB2A06560779BF19D6A3CE356517EA14" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404_terseLabel_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404_label_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404" xlink:to="lab_us-gaap_StatementBusinessSegmentsAxis_EB5E029192013347EBEECE356517E404" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31_label_en-US" xlink:label="lab_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31" xlink:to="lab_us-gaap_SegmentDomain_7465AA78DD7191291B9ACE356517AF31" xlink:type="arc"/>
<link:label id="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F_terseLabel_en-US" xlink:label="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmaceuticals </link:label>
<link:label id="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F_label_en-US" xlink:label="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:label id="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F_documentation_en-US" xlink:label="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:to="lab_opk_PharmaceuticalMember_401BB9E619F01160BB74CE3565176B8F" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D_terseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:label id="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D_label_en-US" xlink:label="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Diagnostics [Member] </link:label>
<link:label id="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D_documentation_en-US" xlink:label="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Diagnostics. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:to="lab_opk_DiagnosticsMember_4E8BF9508C0498794272CE356517811D" xlink:type="arc"/>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A_terseLabel_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A_label_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A_documentation_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:to="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_5BE5203B40EFE10D8D47CE356517375A" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill and intangible assets </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_2BF5EA91180B16A11A9CCE356518F912" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, estimated useful lives </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Asset, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9405D32D8504B26DFA7DCE35651807B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of revenue </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F" xlink:to="lab_us-gaap_ConcentrationRiskPercentage1_12153296248F1D8D3DCDCE356518835F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475_verboseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total deferred revenue related to other revenues </link:label>
<link:label id="lab_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475_label_en-US" xlink:label="lab_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475" xlink:to="lab_us-gaap_DeferredRevenue_1EE91600E903DAA0863FCE3565189475" xlink:type="arc"/>
<link:label id="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC_terseLabel_en-US" xlink:label="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from sale of intellectual property </link:label>
<link:label id="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC_label_en-US" xlink:label="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Sale Of Intellectual Property </link:label>
<link:label id="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC_documentation_en-US" xlink:label="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue From Sale Of Intellectual Property </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_RevenueFromSaleOfIntellectualProperty" xlink:label="loc_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:to="lab_opk_RevenueFromSaleOfIntellectualProperty_7182181786A3C4DCDA72CE356518A2FC" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_09ABD5AACB934002A90BCE35651813B6_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_09ABD5AACB934002A90BCE35651813B6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_09ABD5AACB934002A90BCE35651813B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_09ABD5AACB934002A90BCE35651813B6" xlink:to="lab_us-gaap_AccountsReceivableNetCurrent_09ABD5AACB934002A90BCE35651813B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_D1E3B6D184EB20BBFD49CE3565186798_terseLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_D1E3B6D184EB20BBFD49CE3565186798" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_D1E3B6D184EB20BBFD49CE3565186798" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_D1E3B6D184EB20BBFD49CE3565186798" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_D1E3B6D184EB20BBFD49CE3565186798" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation expense for continuing operations </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583" xlink:to="lab_us-gaap_ShareBasedCompensation_CDBEBC4B9D79045E6AA0CE3565185583" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Useful life </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_AF4995715184535A795ACE35651823B3" xlink:type="arc"/>
<link:label id="lab_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA_terseLabel_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of reportable segments </link:label>
<link:label id="lab_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA_label_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Reportable Segments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA" xlink:to="lab_us-gaap_NumberOfReportableSegments_F47FA65AF4AA36BEB237CE35651896BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD_terseLabel_en-US" xlink:label="lab_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of operating segments </link:label>
<link:label id="lab_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD_label_en-US" xlink:label="lab_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Operating Segments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NumberOfOperatingSegments" xlink:label="loc_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD" xlink:to="lab_us-gaap_NumberOfOperatingSegments_CCB42FEFA7C300E98209CE35651822AD" xlink:type="arc"/>
<link:label id="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D_terseLabel_en-US" xlink:label="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Release of OPKO's valuation allowance </link:label>
<link:label id="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D_label_en-US" xlink:label="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D" xlink:to="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_2733813A9711374EEE69CE356518067D" xlink:type="arc"/>
<link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9_terseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrual for uncertain tax positions </link:label>
<link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9" xlink:to="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_AADDEFC14E7E325DD9E5CE356518ECC9" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Estimate of possible loss </link:label>
<link:label id="lab_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Examination, Estimate of Possible Loss </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss" xlink:label="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC" xlink:to="lab_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_CDB72070B33945F33656CE356518C2DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareAbstract_531DE4EF1871D9CB6EAED9B9B9A5504E_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareAbstract_531DE4EF1871D9CB6EAED9B9B9A5504E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_531DE4EF1871D9CB6EAED9B9B9A5504E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareAbstract_531DE4EF1871D9CB6EAED9B9B9A5504E" xlink:to="lab_us-gaap_EarningsPerShareAbstract_531DE4EF1871D9CB6EAED9B9B9A5504E" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_6318380E39F0DB3D7755D9B9B9A746DC_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_6318380E39F0DB3D7755D9B9B9A746DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) attributable to common shareholders, basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_6318380E39F0DB3D7755D9B9B9A746DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_6318380E39F0DB3D7755D9B9B9A746DC" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_6318380E39F0DB3D7755D9B9B9A746DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972_terseLabel_en-US" xlink:label="lab_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Add: Interest on 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972_label_en-US" xlink:label="lab_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest on Convertible Debt, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestOnConvertibleDebtNetOfTax" xlink:label="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972" xlink:to="lab_us-gaap_InterestOnConvertibleDebtNetOfTax_7AF39905E2B53E26B1C6D9B9B9A80972" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) attributable to common shareholders, diluted </link:label>
<link:label id="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D_label_en-US" xlink:label="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss) Available to Common Stockholders, Diluted </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D" xlink:to="lab_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_2F57377FA1796660E5D5D9B9B9A80F7D" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock options (shares) </link:label>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_079866B670FD11433CF5D9B9B9A87398" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Warrants (shares) </link:label>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Incremental Common Shares Attributable to Dilutive Effect of Call Options and Warrants </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_270C931E3193721EA567D9B9B9A860BB" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes (shares) </link:label>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_62E5DDBFA82EF2B00310D9B9B9A8135E" xlink:type="arc"/>
<link:label id="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dilutive potential shares (shares) </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number Diluted Shares Outstanding Adjustment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE" xlink:to="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4AC630EDA1C22D69EF0BD9B9B9A8C2CE" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704_label_en-US" xlink:label="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Segment Reporting Information, by Segment [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704" xlink:to="lab_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_781011E45E2ECBAE28C0CEE0AF94D704" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B" xlink:to="lab_us-gaap_ConsolidationItemsAxis_9A1A423B7F02DF5775D9CEE0AF94D05B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F" xlink:to="lab_us-gaap_ConsolidationItemsDomain_EF93613E3A41DFFE9516CEE0AF946E2F" xlink:type="arc"/>
<link:label id="lab_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280_verboseLabel_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intersegment Elimination </link:label>
<link:label id="lab_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280_label_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intersegment Eliminations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:label="loc_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280" xlink:to="lab_us-gaap_IntersegmentEliminationMember_F57614A11211481BBB9FCEE0AF941280" xlink:type="arc"/>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk </link:label>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5_label_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5" xlink:to="lab_us-gaap_CustomerConcentrationRiskMember_B948E19CA529E6BA58F6CEE0AF941FD5" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D" xlink:to="lab_us-gaap_SalesRevenueNetMember_B2CD1F89B01AF3C49325CEE0AF95D83D" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4_label_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4" xlink:to="lab_us-gaap_SegmentReportingInformationLineItems_BF5EDE1F10E18E4653BFCEE0AF95E3A4" xlink:type="arc"/>
<link:label id="lab_us-gaap_Revenues_78DEE8D377A60E8CB7E6CEE0AF95620E_verboseLabel_en-US" xlink:label="lab_us-gaap_Revenues_78DEE8D377A60E8CB7E6CEE0AF95620E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment sales </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_78DEE8D377A60E8CB7E6CEE0AF95620E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Revenues_78DEE8D377A60E8CB7E6CEE0AF95620E" xlink:to="lab_us-gaap_Revenues_78DEE8D377A60E8CB7E6CEE0AF95620E" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment allocation of interest expense </link:label>
<link:label id="lab_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2_label_en-US" xlink:label="lab_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2" xlink:to="lab_us-gaap_InterestExpense_6C5BB3C4EE608D30E1BCCEE0AF9547E2" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_1056F2F81C4BE2CFF62CCEE0AF95C3D4_verboseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_1056F2F81C4BE2CFF62CCEE0AF95C3D4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Percentage of product revenue contributed by customer </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_1056F2F81C4BE2CFF62CCEE0AF95C3D4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskPercentage1_1056F2F81C4BE2CFF62CCEE0AF95C3D4" xlink:to="lab_us-gaap_ConcentrationRiskPercentage1_1056F2F81C4BE2CFF62CCEE0AF95C3D4" xlink:type="arc"/>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C_verboseLabel_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of customer represented </link:label>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C_label_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Number of Customers </link:label>
<link:label id="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C_documentation_en-US" xlink:label="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of customer representation. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ConcentrationRiskNumberofCustomers" xlink:label="loc_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:to="lab_opk_ConcentrationRiskNumberofCustomers_76A035439C2FEE887A28CEE0AF95AC7C" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> EARNINGS (LOSS) PER SHARE </link:label>
<link:label id="lab_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A" xlink:to="lab_us-gaap_EarningsPerShareTextBlock_F7E935CE5074405A526086A4518EF37A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F3D74F2ED528D8FD7B853FD8250916B2_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_B1F70ACCBC9855FD81FE1713E4E9AD2F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in accumulated other comprehensive income net of tax </link:label>
<link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_F3D74F2ED528D8FD7B853FD8250916B2_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_B1F70ACCBC9855FD81FE1713E4E9AD2F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_B1F70ACCBC9855FD81FE1713E4E9AD2F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_B1F70ACCBC9855FD81FE1713E4E9AD2F" xlink:to="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_B1F70ACCBC9855FD81FE1713E4E9AD2F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_72F2E5A68AEAE03EB2FFD8D752A5FA75" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E6813F7BB3C0C00BB308D8D752A545E2" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> On or after February 1, 2017 and before February 1, 2019 </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period One [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_50C86ECA33456D8A3F3FD8D752A50782" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_28EBEDA971D3F646A659D8D752AA294F_verboseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_28EBEDA971D3F646A659D8D752AA294F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_28EBEDA971D3F646A659D8D752AA294F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_28EBEDA971D3F646A659D8D752AA294F" xlink:to="lab_opk_OPKOHealthEuropeMember_28EBEDA971D3F646A659D8D752AA294F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Debt face amount </link:label>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Face Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF" xlink:to="lab_us-gaap_DebtInstrumentFaceAmount_D6F9A544038D64595D77D8D752AA32EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_AD1491DEF543A10932A4D8D752AAB0BA_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_AD1491DEF543A10932A4D8D752AAB0BA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate of notes payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_AD1491DEF543A10932A4D8D752AAB0BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_AD1491DEF543A10932A4D8D752AAB0BA" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_AD1491DEF543A10932A4D8D752AAB0BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equivalent redemption price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption Price, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_807952F7C37982826F9DD8D752AA88C8" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A_verboseLabel_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of trading days applicable conversion price </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A_label_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold For Trading Days </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A_documentation_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold For Trading Days </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtInstrumentConvertibleThresholdForTradingDays" xlink:label="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:to="lab_opk_DebtInstrumentConvertibleThresholdForTradingDays_D8407DAAD286BBD7D01CD8D752AB7C5A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionOriginalDebtAmount1_4A81E1057A6490DF0145D8D752AB28AC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionOriginalDebtAmount1_4A81E1057A6490DF0145D8D752AB28AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Convertible notes, conversion </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="loc_us-gaap_DebtConversionOriginalDebtAmount1_4A81E1057A6490DF0145D8D752AB28AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionOriginalDebtAmount1_4A81E1057A6490DF0145D8D752AB28AC" xlink:to="lab_us-gaap_DebtConversionOriginalDebtAmount1_4A81E1057A6490DF0145D8D752AB28AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Convertible debt, stock issued from conversion </link:label>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Converted Instrument, Shares Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A" xlink:to="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_E35B31A29D33E9DBDAF6D8D752AB526A" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest paid </link:label>
<link:label id="lab_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255_label_en-US" xlink:label="lab_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Paid </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255" xlink:to="lab_us-gaap_InterestPaid_735F7C4CFFFEF35A2C57D8D752AB4255" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF_terseLabel_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gains (losses) on extinguishment of debt </link:label>
<link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF_label_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gains (Losses) on Extinguishment of Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF" xlink:to="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_D85BD9818B1A54A95B7ED8D752ABE4AF" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Converted amount </link:label>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Converted Instrument, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E" xlink:to="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_9F09DD03B727A485A48AD8D752ABD06E" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_C004C13AF45938925E06D8D752AB5DB6_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_C004C13AF45938925E06D8D752AB5DB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_C004C13AF45938925E06D8D752AB5DB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_C004C13AF45938925E06D8D752AB5DB6" xlink:to="lab_us-gaap_LongTermDebt_C004C13AF45938925E06D8D752AB5DB6" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain (loss) on embedded derivative </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Gain (Loss) on Embedded Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189" xlink:to="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_9248739AA6B206F09CC5D8D752AB0189" xlink:type="arc"/>
<link:label id="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7_terseLabel_en-US" xlink:label="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Eligible receivables percentage </link:label>
<link:label id="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7_label_en-US" xlink:label="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Covenant, Eligible Receivables Percentage </link:label>
<link:label id="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7_documentation_en-US" xlink:label="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Covenant, Eligible Receivables Percentage </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage" xlink:label="loc_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:to="lab_opk_LineofCreditFacilityCovenantEligibleReceivablesPercentage_0320D827109E6C758CB5D8D752AB9CA7" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Early termination fee </link:label>
<link:label id="lab_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Fee Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentFeeAmount" xlink:label="loc_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560" xlink:to="lab_us-gaap_DebtInstrumentFeeAmount_CEA7DBA45ED306C77C44D8D752ABE560" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amount outstanding </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Fair Value of Amount Outstanding </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding" xlink:label="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C" xlink:to="lab_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1A313F17B9541AD563B1D8D752AB814C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate at period end </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Interest Rate at Period End </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B" xlink:to="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8CC232BC2ED06ADDCE02D8D752AB342B" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB_verboseLabel_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of financial institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB_label_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instruments, Number of Financial Institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB_documentation_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of financial institutions. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtInstrumentsNumberofFinancialInstitutions" xlink:label="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:to="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_35A51A8359B23AA2E7F0D8D752ABD5DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C_terseLabel_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average interest rate </link:label>
<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C_label_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt, Weighted Average Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C" xlink:to="lab_us-gaap_DebtWeightedAverageInterestRate_4F9D4C205C148FA2B963D8D752AB757C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest rates </link:label>
<link:label id="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE_label_en-US" xlink:label="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Percentage Bearing Variable Interest, Percentage Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE" xlink:to="lab_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_20BE01BE48C97CF7CC9ED8D752AC5BFE" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F" xlink:to="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A032589375192DC5F727D371B71BD66F" xlink:type="arc"/>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021_label_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021_documentation_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PharmsynthezNoteReceivableMember" xlink:label="loc_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:to="lab_opk_PharmsynthezNoteReceivableMember_AD6E04513C013B77F655D371B71B7021" xlink:type="arc"/>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA_terseLabel_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Rxi Pharmaceuticals Corporation </link:label>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA_label_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Rxi Pharmaceuticals Corporation [Member] </link:label>
<link:label id="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA_documentation_en-US" xlink:label="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Rxi pharmaceuticals corporation. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_RxiPharmaceuticalsCorporationMember" xlink:label="loc_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:to="lab_opk_RxiPharmaceuticalsCorporationMember_30255B9507C9EF681520D371B71C82AA" xlink:type="arc"/>
<link:label id="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824_terseLabel_en-US" xlink:label="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Tesaro </link:label>
<link:label id="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824_label_en-US" xlink:label="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Tesaro [Member] </link:label>
<link:label id="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824_documentation_en-US" xlink:label="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tesaro [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_TesaroMember" xlink:label="loc_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:to="lab_opk_TesaroMember_3452BA2A6DA4926973C8D371B721C824" xlink:type="arc"/>
<link:label id="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB_terseLabel_en-US" xlink:label="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Merck </link:label>
<link:label id="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB_label_en-US" xlink:label="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Merck [Member] </link:label>
<link:label id="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB_documentation_en-US" xlink:label="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Merck [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_MerckMember" xlink:label="loc_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:to="lab_opk_MerckMember_58DA0D1CFB2F1372D0A8D371B7210BDB" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF" xlink:to="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_33E0A1B4F2016F17DE63D371B722B3FF" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-refundable upfront payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363_label_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementUpfrontPayment" xlink:label="loc_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:to="lab_opk_CollaborativeArrangementUpfrontPayment_91C3B83826B0027AF075D371B722A363" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment to be received </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86_label_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangement.MaximumMilestonePayments" xlink:label="loc_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:to="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_DB31C58DC8B78D23D7DED371B7227B86" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredRevenue_85B5440A04340F12B296D371B722A6FF_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenue_85B5440A04340F12B296D371B722A6FF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_85B5440A04340F12B296D371B722A6FF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenue_85B5440A04340F12B296D371B722A6FF" xlink:to="lab_us-gaap_DeferredRevenue_85B5440A04340F12B296D371B722A6FF" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment ranges </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementMilestonePayment" xlink:label="loc_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:to="lab_opk_CollaborativeArrangementMilestonePayment_D50C08EC843E23631B25D371B72258F3" xlink:type="arc"/>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097_terseLabel_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Upfront payment under license agreements </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097_label_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097_documentation_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment" xlink:label="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:to="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_A0E1D046C479BE00D74ED371B722D097" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementMilestonePaymentReceived" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:to="lab_opk_CollaborativeArrangementMilestonePaymentReceived_E06F7C2792E3299BD5D8D371B722C328" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9_label_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeAgreementAdditionalMilestonePayment" xlink:label="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:to="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_52F294F75AB0EF4396E4D371B722F4A9" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amount payable each year </link:label>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA_label_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Amount Payable Each Year </link:label>
<link:label id="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Amount Payable Each Year </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementAmountPayableEachYear" xlink:label="loc_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:to="lab_opk_CollaborativeArrangementAmountPayableEachYear_6BDB86AB069411A27613D371B72254CA" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Period for yearly payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4_label_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Period for Yearly Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Period for Yearly Payment </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeArrangementPeriodforYearlyPayment" xlink:label="loc_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:to="lab_opk_CollaborativeArrangementPeriodforYearlyPayment_F5C574AED071F36A0324D371B7227DA4" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Period from first commercial sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8_label_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CollaborativeAgreementPeriodfromFirstCommercialSale" xlink:label="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:to="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_4E69EC85CBF031A265C9D371B7229CE8" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7_verboseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payments </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Estimated Milestone Payments To Be Received </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estimated milestone payment to be received. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" xlink:label="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:to="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_BA25D3346A4FA83AFCFFD371B72267F7" xlink:type="arc"/>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867_verboseLabel_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Basis of presentation </link:label>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867_label_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Basis of Accounting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867" xlink:to="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_3753B64476869DB9053C867D85D96867" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Principles of consolidation </link:label>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4_label_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4" xlink:to="lab_us-gaap_ConsolidationPolicyTextBlock_17EE9372AB9095FD2F76867D85D9EFD4" xlink:type="arc"/>
<link:label id="lab_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4_verboseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Use of estimates </link:label>
<link:label id="lab_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Use of Estimates, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4" xlink:to="lab_us-gaap_UseOfEstimates_9E11257DC7CF86D0A31D867D85D97BF4" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331" xlink:to="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_FDD3DC6FF626B7AA40AA867D85D91331" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories </link:label>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A_label_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A" xlink:to="lab_us-gaap_InventoryPolicyTextBlock_F8158092679B849D22D4867D85DAE35A" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4_verboseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill and intangible assets </link:label>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_47F1D097C375D05F790C867D85DAAFB4" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair value measurements </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1" xlink:to="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_F525E86AABAA0DB70C68867D85DADCE1" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671" xlink:to="lab_us-gaap_BusinessCombinationsPolicy_C5243526D664052084AD867D85DA7671" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative financial instruments </link:label>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock_DFD83BCA55FF571E3B43867D85DAB56A" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue recognition </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83" xlink:to="lab_us-gaap_RevenueRecognitionPolicyTextBlock_C44D50C7BF6FFEE2D183867D85DADD83" xlink:type="arc"/>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04_verboseLabel_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04_label_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts [Policy Text Block] </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04_documentation_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:label="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:to="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_4AF88A0632A0CB41FF17867D85DA1A04" xlink:type="arc"/>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230_verboseLabel_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation </link:label>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230_label_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Compensation Related Costs, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CompensationRelatedCostsPolicyTextBlock" xlink:label="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230" xlink:to="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_0A1A9AC17FE6B4EC70B5867D85DAA230" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_80CC848D789EAAD54998869D1452694C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Impairment of Long-Lived Assets </link:label>
<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313_label_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:label="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313" xlink:to="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_E9F9654AA206BD4DB6CD869E07B61313" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Research and development expenses </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_4156B8FE52C5DC409ABF867D85DA3080" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C_verboseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Segment reporting </link:label>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C_label_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C" xlink:to="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_6442DA9E3B30391A0FA1867D85DAAE2C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest entities </link:label>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161_label_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Variable Interest Entity, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:label="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161" xlink:to="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_395A61A06E28FCE473B9867D85DA8161" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0_label_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_52FA64676171FA490569867D85DA5CB0" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Taxes </link:label>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B_label_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B" xlink:to="lab_us-gaap_IncomeTaxPolicyTextBlock_7BD22A153A05B530D3E9867D85DA744B" xlink:type="arc"/>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Recent accounting pronouncements </link:label>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD" xlink:to="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_6691E699FBDFF4842930867D85DA68CD" xlink:type="arc"/>
<link:label id="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F_terseLabel_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> STRATEGIC ALLIANCES </link:label>
<link:label id="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F_label_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Strategic Alliances [Text Block] </link:label>
<link:label id="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F_documentation_en-US" xlink:label="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Strategic Alliances [Text Block] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_StrategicAlliancesTextBlock" xlink:label="loc_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:to="lab_opk_StrategicAlliancesTextBlock_8C0ED908751955CECFBED371B72A4D8F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA" xlink:to="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_00825577417233CB45B6D371B8A5B6BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities [Axis] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_C6BE90DB0ACC2964AF33D371B8A56D9D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities, Name [Domain] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D" xlink:to="lab_us-gaap_AntidilutiveSecuritiesNameDomain_B8438281A5A8165DCADBD371B8A51F2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_845EDF8808A80FB1C222D371B8A5B244" xlink:type="arc"/>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1_verboseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Potential common shares </link:label>
<link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4C75FA0718E3749189D2D371B8A50CD1" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock warrant and common stock options exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Stock Options and Warrants Exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of common stock warrant and common stock options exercised. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:to="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_521F317565DEB4207F4BD371B8A66D13" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock issued for stock warrant and stock options exercised </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Stock Options and Warrants Exercised, Net of Shares Surrendered in Lieu of Cash Payment </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of common stock issued for stock warrant and stock options exercised. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" xlink:label="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:to="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_3F8F09136F9646AA7D56D371B8A643B7" xlink:type="arc"/>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E_verboseLabel_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Shares surrendered in lieu of cash payment </link:label>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E_label_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Surrendered in Lieu of Cash Payment </link:label>
<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E_documentation_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares surrendered in lieu of cash payment. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SharesSurrenderedInLieuOfCashPayment" xlink:label="loc_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:to="lab_opk_SharesSurrenderedInLieuOfCashPayment_F5E8CAFF42A103AF510DD371B8A6087E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_553FB07FB4F312882B796BE7352606C6_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_987D7A0593A755979CF36961E2EB5031" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> DERIVATIVE CONTRACTS </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_553FB07FB4F312882B796BE7352606C6_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_987D7A0593A755979CF36961E2EB5031" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments and Hedging Activities Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_987D7A0593A755979CF36961E2EB5031" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_987D7A0593A755979CF36961E2EB5031" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_987D7A0593A755979CF36961E2EB5031" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtDisclosureTextBlock_0F6A47974B497EA82EC46BE7339BE57C_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock_5796BF50689853DE81F7BA7CC7E637AB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> DEBT </link:label>
<link:label id="lab_us-gaap_DebtDisclosureTextBlock_0F6A47974B497EA82EC46BE7339BE57C_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock_5796BF50689853DE81F7BA7CC7E637AB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_5796BF50689853DE81F7BA7CC7E637AB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureTextBlock_5796BF50689853DE81F7BA7CC7E637AB" xlink:to="lab_us-gaap_DebtDisclosureTextBlock_5796BF50689853DE81F7BA7CC7E637AB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_6142BF9886FF84264E8C6BE73399797A_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_3DA9797868AD5B8E8CBBE43DD9E8D140" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maturity date </link:label>
<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_6142BF9886FF84264E8C6BE73399797A_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_3DA9797868AD5B8E8CBBE43DD9E8D140" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Maturity Date </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_3DA9797868AD5B8E8CBBE43DD9E8D140" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentMaturityDate_3DA9797868AD5B8E8CBBE43DD9E8D140" xlink:to="lab_us-gaap_DebtInstrumentMaturityDate_3DA9797868AD5B8E8CBBE43DD9E8D140" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_7A6751E861ABAD13BCFC6BE73399885B_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B956DD9BCBD954C7ADA538890CACDDDD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Risk-free interest rate </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_7A6751E861ABAD13BCFC6BE73399885B_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B956DD9BCBD954C7ADA538890CACDDDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Risk Free Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B956DD9BCBD954C7ADA538890CACDDDD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B956DD9BCBD954C7ADA538890CACDDDD" xlink:to="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B956DD9BCBD954C7ADA538890CACDDDD" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_6FCB203DAF43695F30F26BE7339A9F9B_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_F34DDF1BD06353F3BBCFCA69B822FA8D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated stock volatility </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_6FCB203DAF43695F30F26BE7339A9F9B_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_F34DDF1BD06353F3BBCFCA69B822FA8D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Expected Volatility Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_F34DDF1BD06353F3BBCFCA69B822FA8D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_F34DDF1BD06353F3BBCFCA69B822FA8D" xlink:to="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_F34DDF1BD06353F3BBCFCA69B822FA8D" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_50580112025617AB8C076BE7339A2FCD_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_CF619141F5CF5E0DA6013F35B630486F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated credit spread </link:label>
<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_50580112025617AB8C076BE7339A2FCD_label_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_CF619141F5CF5E0DA6013F35B630486F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Entity Credit Risk </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsEntityCreditRisk" xlink:label="loc_us-gaap_FairValueInputsEntityCreditRisk_CF619141F5CF5E0DA6013F35B630486F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsEntityCreditRisk_CF619141F5CF5E0DA6013F35B630486F" xlink:to="lab_us-gaap_FairValueInputsEntityCreditRisk_CF619141F5CF5E0DA6013F35B630486F" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_BDCB93B976C6696226966BE734384D4B_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract_D77E016BC159537C929E7FA0AF44DF20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Financial Position [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_D77E016BC159537C929E7FA0AF44DF20" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_D77E016BC159537C929E7FA0AF44DF20" xlink:to="lab_us-gaap_StatementOfFinancialPositionAbstract_D77E016BC159537C929E7FA0AF44DF20" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_CAF7F2820084C804D6596BE734397CDF_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_2CD701C5ADD652D5B5913219EB65FAE2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, par value (in dollars per share) </link:label>
<link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_CAF7F2820084C804D6596BE734397CDF_label_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_2CD701C5ADD652D5B5913219EB65FAE2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Par or Stated Value Per Share </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_2CD701C5ADD652D5B5913219EB65FAE2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockParOrStatedValuePerShare_2CD701C5ADD652D5B5913219EB65FAE2" xlink:to="lab_us-gaap_CommonStockParOrStatedValuePerShare_2CD701C5ADD652D5B5913219EB65FAE2" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockSharesAuthorized_AFB852AEDDDF0E82C53C6BE73439426C_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_7C780F605BC051BBBEF269C12D057CC3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares authorized (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesAuthorized_AFB852AEDDDF0E82C53C6BE73439426C_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_7C780F605BC051BBBEF269C12D057CC3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares Authorized </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_7C780F605BC051BBBEF269C12D057CC3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesAuthorized_7C780F605BC051BBBEF269C12D057CC3" xlink:to="lab_us-gaap_CommonStockSharesAuthorized_7C780F605BC051BBBEF269C12D057CC3" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockSharesIssued_D1EAA639E2D75BC31D0B6BE73439C1F5_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_BF4301235E995DCB97E3978C77738968" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares issued (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesIssued_D1EAA639E2D75BC31D0B6BE73439C1F5_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_BF4301235E995DCB97E3978C77738968" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_BF4301235E995DCB97E3978C77738968" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesIssued_BF4301235E995DCB97E3978C77738968" xlink:to="lab_us-gaap_CommonStockSharesIssued_BF4301235E995DCB97E3978C77738968" xlink:type="arc"/>
<link:label id="lab_us-gaap_TreasuryStockShares_95D7E82DA74EB51CF2536BE7343912B0_verboseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_83BD42EBD0DF5CE0B4877857560179E5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Treasury stock, shares (in shares) </link:label>
<link:label id="lab_us-gaap_TreasuryStockShares_95D7E82DA74EB51CF2536BE7343912B0_label_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_83BD42EBD0DF5CE0B4877857560179E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock, Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_83BD42EBD0DF5CE0B4877857560179E5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockShares_83BD42EBD0DF5CE0B4877857560179E5" xlink:to="lab_us-gaap_TreasuryStockShares_83BD42EBD0DF5CE0B4877857560179E5" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_AE80ABB175AB92326F0E6BE73439BCEF_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_DB7AE2AEE22D57FAB2F8D34DB6588827" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total assets in variable interest entity </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_AE80ABB175AB92326F0E6BE73439BCEF_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_DB7AE2AEE22D57FAB2F8D34DB6588827" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Consolidated, Carrying Amount, Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_DB7AE2AEE22D57FAB2F8D34DB6588827" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_DB7AE2AEE22D57FAB2F8D34DB6588827" xlink:to="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_DB7AE2AEE22D57FAB2F8D34DB6588827" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_EF94657EDBF6A7FF3F396BE73439D24D_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_6AA639DBABD85F99999B99874A25D05F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total liability in variable interest entity </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_EF94657EDBF6A7FF3F396BE73439D24D_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_6AA639DBABD85F99999B99874A25D05F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Consolidated, Carrying Amount, Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_6AA639DBABD85F99999B99874A25D05F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_6AA639DBABD85F99999B99874A25D05F" xlink:to="lab_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_6AA639DBABD85F99999B99874A25D05F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Related Party Transactions, by Related Party [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Related Party Transactions, by Related Party [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D" xlink:to="lab_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_72301CEA839A16C65044ED2DF3D04C2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series C Preferred Stock </link:label>
<link:label id="lab_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678_label_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Series C Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678" xlink:to="lab_us-gaap_SeriesCPreferredStockMember_142BF47C548A8E3C93BEED2DF3D03678" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Axis] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769" xlink:to="lab_us-gaap_RelatedPartyTransactionAxis_D768B78D2897C057517FED2DF3D06769" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Domain] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198" xlink:to="lab_us-gaap_RelatedPartyTransactionDomain_2AE3F662E5BA35CBE5BCED2DF3D06198" xlink:type="arc"/>
<link:label id="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74_terseLabel_en-US" xlink:label="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> FTC Filings </link:label>
<link:label id="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74_label_en-US" xlink:label="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> FTC Filings [Member] </link:label>
<link:label id="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74_documentation_en-US" xlink:label="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> FTC Filings [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FTCFilingsMember" xlink:label="loc_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:to="lab_opk_FTCFilingsMember_A51C3CD3968D6107890BED2DF3D00C74" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Method Investee </link:label>
<link:label id="lab_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investee [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityMethodInvesteeMember" xlink:label="loc_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB" xlink:to="lab_us-gaap_EquityMethodInvesteeMember_E12C079DEFECB074EA31ED2DF3D19EBB" xlink:type="arc"/>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686_terseLabel_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense </link:label>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686_label_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense [Member] </link:label>
<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686_documentation_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ReimbursementOfTravelExpenseMember" xlink:label="loc_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:to="lab_opk_ReimbursementOfTravelExpenseMember_D75B88C210EEF7F01824ED2DF3D1F686" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party [Axis] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004" xlink:to="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_513979B1266BE879F96AED2DF3D1D004" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party [Domain] </link:label>
<link:label id="lab_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6_label_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6" xlink:to="lab_us-gaap_RelatedPartyDomain_DEC45AA68ECBD01D3088ED2DF3D10AF6" xlink:type="arc"/>
<link:label id="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610_terseLabel_en-US" xlink:label="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dr Frost </link:label>
<link:label id="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610_label_en-US" xlink:label="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Dr Frost [Member] </link:label>
<link:label id="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610_documentation_en-US" xlink:label="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Dr Frost. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DrFrostMember" xlink:label="loc_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:to="lab_opk_DrFrostMember_F833CCB7F7233AE3F64EED2DF3D10610" xlink:type="arc"/>
<link:label id="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73_terseLabel_en-US" xlink:label="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dr. Hsiao and Mr. Rubin </link:label>
<link:label id="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73_label_en-US" xlink:label="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Dr. Hsiao and Mr. Rubin [Member] </link:label>
<link:label id="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73_documentation_en-US" xlink:label="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Dr. Hsiao and Mr. Rubin [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_Dr.HsiaoandMr.RubinMember" xlink:label="loc_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:to="lab_opk_Dr.HsiaoandMr.RubinMember_F5F0B9A64F2AD449F7F5ED2DF3D12C73" xlink:type="arc"/>
<link:label id="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB_terseLabel_en-US" xlink:label="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Frost Gamma Investments Trust and Hsu Gamma Investment, L.P. </link:label>
<link:label id="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB_label_en-US" xlink:label="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Frost Gamma Investments Trust and Hsu Gamma Investment, L.P. [Member] </link:label>
<link:label id="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB_documentation_en-US" xlink:label="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Frost Gamma Investments Trust and Hsu Gamma Investment, L.P. [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member" xlink:label="loc_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:to="lab_opk_FrostGammaInvestmentsTrustandHsuGammaInvestmentL.P.Member_5F0CDDE68E6B6B998452ED2DF3D114BB" xlink:type="arc"/>
<link:label id="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F_verboseLabel_en-US" xlink:label="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Teva </link:label>
<link:label id="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F_label_en-US" xlink:label="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Teva Pharmaceutical Industries [Member] </link:label>
<link:label id="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F_documentation_en-US" xlink:label="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Teva pharmaceutical industries limited. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_TevaPharmaceuticalIndustriesMember" xlink:label="loc_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:to="lab_opk_TevaPharmaceuticalIndustriesMember_982BDD435D3E631E6034ED2DF3D1130F" xlink:type="arc"/>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F_verboseLabel_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Frost Real Estate Holdings LLC </link:label>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F_label_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Frost Real Estate Holdings LLC [Member] </link:label>
<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F_documentation_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Frost real estate holdings LLC. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FrostRealEstateHoldingsLLCMember" xlink:label="loc_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:to="lab_opk_FrostRealEstateHoldingsLLCMember_129717971FF25FDBBB2BED2DF3D1D90F" xlink:type="arc"/>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A_terseLabel_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> MabVax </link:label>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A_label_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MabVax Therapeutics Holdings, Inc. [Member] </link:label>
<link:label id="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A_documentation_en-US" xlink:label="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> MabVax Therapeutics Holdings, Inc. [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_MabVaxTherapeuticsHoldingsInc.Member" xlink:label="loc_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:to="lab_opk_MabVaxTherapeuticsHoldingsInc.Member_979DE2666F60A7DCF3BFED2DF3D1952A" xlink:type="arc"/>
<link:label id="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385_terseLabel_en-US" xlink:label="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ARNO </link:label>
<link:label id="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385_label_en-US" xlink:label="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ARNO [Member] </link:label>
<link:label id="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385_documentation_en-US" xlink:label="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ARNO [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ARNOMember" xlink:label="loc_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:to="lab_opk_ARNOMember_3A8932C7151EF192A276ED2DF3D1C385" xlink:type="arc"/>
<link:label id="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E_verboseLabel_en-US" xlink:label="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Chromadex Corporation </link:label>
<link:label id="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E_label_en-US" xlink:label="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Chromadex Corporation [Member] </link:label>
<link:label id="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E_documentation_en-US" xlink:label="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ChromaDex corporation. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ChromadexCorporationMember" xlink:label="loc_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:to="lab_opk_ChromadexCorporationMember_23FAC0214D8ABA007ACCED2DF3D1910E" xlink:type="arc"/>
<link:label id="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1_terseLabel_en-US" xlink:label="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Biozone Pharmaceuticals Inc </link:label>
<link:label id="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1_label_en-US" xlink:label="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Biozone Pharmaceuticals Inc [Member] </link:label>
<link:label id="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1_documentation_en-US" xlink:label="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Biozone pharmaceuticals inc. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="loc_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:to="lab_opk_BiozonePharmaceuticalsIncMember_C5D8C4AE9894C3E0B923ED2DF3D15EE1" xlink:type="arc"/>
<link:label id="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D_terseLabel_en-US" xlink:label="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Biozone </link:label>
<link:label id="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D_label_en-US" xlink:label="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Biozone [Member] </link:label>
<link:label id="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D_documentation_en-US" xlink:label="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Biozone. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BiozoneMember" xlink:label="loc_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:to="lab_opk_BiozoneMember_16355A856AE2BE934ED6ED2DF3D1539D" xlink:type="arc"/>
<link:label id="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492_terseLabel_en-US" xlink:label="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Biologics </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492_label_en-US" xlink:label="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492_documentation_en-US" xlink:label="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:to="lab_opk_OPKOBiologicsMember_F8AD2B075FD8D37B2E91ED2DF3D28492" xlink:type="arc"/>
<link:label id="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7_verboseLabel_en-US" xlink:label="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> FineTech </link:label>
<link:label id="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7_label_en-US" xlink:label="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> FineTech [Member] </link:label>
<link:label id="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7_documentation_en-US" xlink:label="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> FineTech. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:to="lab_opk_FineTechMember_D4CA2B5087A87778E901ED2DF3D297F7" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Line Items] </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140" xlink:to="lab_us-gaap_RelatedPartyTransactionLineItems_16FAC874DF6ECF9CEC32ED2DF3D26140" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Invested in common shares </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8" xlink:to="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_E98FE357B7E426FD84D0ED2DF3D240B8" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106_verboseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Warrants to purchase common shares </link:label>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Warrant or Right, Number of Securities Called by Warrants or Rights </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106" xlink:to="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9D3BC14265466F1ED413ED2DF3D22106" xlink:type="arc"/>
<link:label id="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61_terseLabel_en-US" xlink:label="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payments for filing fees </link:label>
<link:label id="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61_label_en-US" xlink:label="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for Filing Fees </link:label>
<link:label id="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61_documentation_en-US" xlink:label="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Payments for Filing Fees </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PaymentsforFilingFees" xlink:label="loc_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:to="lab_opk_PaymentsforFilingFees_2E2E2550A9A5EC32E8FFED2DF3D25A61" xlink:type="arc"/>
<link:label id="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F_verboseLabel_en-US" xlink:label="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Beneficially owned held by members </link:label>
<link:label id="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F_label_en-US" xlink:label="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Ownership Percentage Held by Members </link:label>
<link:label id="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F_documentation_en-US" xlink:label="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Ownership percentage held by members. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OwnershipPercentageHeldByMembers" xlink:label="loc_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:to="lab_opk_OwnershipPercentageHeldByMembers_AD485C22CEBC40CA7A76ED2DF3D2115F" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618_terseLabel_en-US" xlink:label="lab_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sale of API to TEVA </link:label>
<link:label id="lab_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618_label_en-US" xlink:label="lab_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue from Related Parties </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618" xlink:to="lab_us-gaap_RevenueFromRelatedParties_A7F2DF1A1CAE02936EB1ED2DF3D3B618" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional investment in common shares </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD" xlink:to="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_C80F5E717B1D6D93A4A1ED2DF3D33DBD" xlink:type="arc"/>
<link:label id="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100_terseLabel_en-US" xlink:label="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Private placement financing </link:label>
<link:label id="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100_label_en-US" xlink:label="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Private Placement Financing </link:label>
<link:label id="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100_documentation_en-US" xlink:label="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Private Placement Financing </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PrivatePlacementFinancing" xlink:label="loc_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:to="lab_opk_PrivatePlacementFinancing_F495996D06E0899D2AA2ED2DF3D36100" xlink:type="arc"/>
<link:label id="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096_verboseLabel_en-US" xlink:label="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Warrants duration </link:label>
<link:label id="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096_label_en-US" xlink:label="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Warrant or Right, Expiration Period </link:label>
<link:label id="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096_documentation_en-US" xlink:label="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Duration of warrants. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ClassofWarrantorRightExpirationPeriod" xlink:label="loc_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:to="lab_opk_ClassofWarrantorRightExpirationPeriod_A1104FE432DA6995997EED2DF3D31096" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Warrants exercisable price (in USD per share) </link:label>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Warrant or Right, Exercise Price of Warrants or Rights </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63" xlink:to="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7DCE67F8986490DA2D26ED2DF3D34C63" xlink:type="arc"/>
<link:label id="lab_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468_terseLabel_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Area of real estate property (in square feet) </link:label>
<link:label id="lab_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468_label_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Area of Real Estate Property </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AreaOfRealEstateProperty" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468" xlink:to="lab_us-gaap_AreaOfRealEstateProperty_71B9F275348F0373880AED2DF3D3F468" xlink:type="arc"/>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payments per month in first year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OperatingLeasesMonthlyPaymentsYearOne" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_B83EC5D777010459C3C5ED2DF3D37470" xlink:type="arc"/>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payments per month in fifth year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Five </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Five </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OperatingLeasesMonthlyPaymentsYearFive" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearFive_2AEF18C12D2B9E96C5BEED2DF3D30C8B" xlink:type="arc"/>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB_negatedTerseLabel_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Rent reduction </link:label>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB_label_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Tenant Improvements, Offset Against Operating Lease in Next Twelve Months </link:label>
<link:label id="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB_documentation_en-US" xlink:label="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tenant Improvements, Offset Against Operating Lease in Next Twelve Months </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths" xlink:label="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:to="lab_opk_TenantImprovementsOffsetAgainstOperatingLeaseinNextTwelveMonths_518939469EBD9EA99A45ED2DF3D38ADB" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement paid to related party for travel </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction, Expenses from Transactions with Related Party </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B" xlink:to="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_0C23FE8A20F7AFEBDFA4ED2DF3D3814B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_CE4F86E224A271D8C6E16BE73487F892_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_8B60C4D769875FBA8FFBD71213BA61BA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of investments classified as available for sale, and carried at fair value </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_CE4F86E224A271D8C6E16BE73487F892_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_8B60C4D769875FBA8FFBD71213BA61BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities Reconciliation [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_8B60C4D769875FBA8FFBD71213BA61BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_8B60C4D769875FBA8FFBD71213BA61BA" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_8B60C4D769875FBA8FFBD71213BA61BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_571AB6CF5B5F2B14F28D6BE73487D30A_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_40D44B731A4F551E8A65D32359BB25C2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Financial assets and liabilities measured at fair value on a recurring basis </link:label>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_571AB6CF5B5F2B14F28D6BE73487D30A_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_40D44B731A4F551E8A65D32359BB25C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_40D44B731A4F551E8A65D32359BB25C2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_40D44B731A4F551E8A65D32359BB25C2" xlink:to="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_40D44B731A4F551E8A65D32359BB25C2" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_30D5FDD453D85251C0BC6BE73487A251_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C87ABAD038E2542BA60A4B50D215F0F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> The carrying amount and estimated fair value of our long-term debt </link:label>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_30D5FDD453D85251C0BC6BE73487A251_label_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C87ABAD038E2542BA60A4B50D215F0F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C87ABAD038E2542BA60A4B50D215F0F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C87ABAD038E2542BA60A4B50D215F0F4" xlink:to="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C87ABAD038E2542BA60A4B50D215F0F4" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_6936F19ADF5D457E7C486BE734871EF9_verboseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Reconcile the beginning and ending balances of Level 3 assets and liabilities </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_6936F19ADF5D457E7C486BE734871EF9_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured On Recurring Basis, Unobservable Input Reconciliation [Table Text Block] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_6936F19ADF5D457E7C486BE734871EF9_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Reconciles beginning and ending balances of level three assets and liabilities. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_F10576C36A60577A98413C81DBD8800E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_DC601E64DE05D503A493B7E28B5D735A_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_993C03D61B2A5BADAB7BD1596D6F76B4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Table] </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_DC601E64DE05D503A493B7E28B5D735A_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_993C03D61B2A5BADAB7BD1596D6F76B4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_993C03D61B2A5BADAB7BD1596D6F76B4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_993C03D61B2A5BADAB7BD1596D6F76B4" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_993C03D61B2A5BADAB7BD1596D6F76B4" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementEquityComponentsAxis_B0A35242DBDA41151CBBB7E28B5D7808_terseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_DF38DA030A3951DCA43B948817864AC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
<link:label id="lab_us-gaap_StatementEquityComponentsAxis_B0A35242DBDA41151CBBB7E28B5D7808_label_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_DF38DA030A3951DCA43B948817864AC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_DF38DA030A3951DCA43B948817864AC0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_DF38DA030A3951DCA43B948817864AC0" xlink:to="lab_us-gaap_StatementEquityComponentsAxis_DF38DA030A3951DCA43B948817864AC0" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityComponentDomain_F17AD3E28B936EA52B00B7E28B5D934B_terseLabel_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_6C51D434B24D5D95A586152A36BAEB84" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Component [Domain] </link:label>
<link:label id="lab_us-gaap_EquityComponentDomain_F17AD3E28B936EA52B00B7E28B5D934B_label_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_6C51D434B24D5D95A586152A36BAEB84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Component [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_6C51D434B24D5D95A586152A36BAEB84" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityComponentDomain_6C51D434B24D5D95A586152A36BAEB84" xlink:to="lab_us-gaap_EquityComponentDomain_6C51D434B24D5D95A586152A36BAEB84" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedTranslationAdjustmentMember_5633296530E37CE023B2B7E28B5D9712_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedTranslationAdjustmentMember_16744EE3977453358EF0B7AF0A28EE08" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency </link:label>
<link:label id="lab_us-gaap_AccumulatedTranslationAdjustmentMember_5633296530E37CE023B2B7E28B5D9712_label_en-US" xlink:label="lab_us-gaap_AccumulatedTranslationAdjustmentMember_16744EE3977453358EF0B7AF0A28EE08" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Foreign Currency Adjustment Attributable to Parent [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_16744EE3977453358EF0B7AF0A28EE08" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedTranslationAdjustmentMember_16744EE3977453358EF0B7AF0A28EE08" xlink:to="lab_us-gaap_AccumulatedTranslationAdjustmentMember_16744EE3977453358EF0B7AF0A28EE08" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_2991CD7A7A0D4AE14345B7E28B5DCCDF_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_41F86A7DF7365A1380D50381EBD4F190" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized gain (loss) in Accumulated OCI </link:label>
<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_2991CD7A7A0D4AE14345B7E28B5DCCDF_label_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_41F86A7DF7365A1380D50381EBD4F190" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Net Investment Gain (Loss) Attributable to Parent [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_41F86A7DF7365A1380D50381EBD4F190" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_41F86A7DF7365A1380D50381EBD4F190" xlink:to="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_41F86A7DF7365A1380D50381EBD4F190" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_40AD48A99907A1D5A67BB7E28B5D359F_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_E82860BA7DC25360A683CA41DCEFC6F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Line Items] </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_40AD48A99907A1D5A67BB7E28B5D359F_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_E82860BA7DC25360A683CA41DCEFC6F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_E82860BA7DC25360A683CA41DCEFC6F0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_E82860BA7DC25360A683CA41DCEFC6F0" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_E82860BA7DC25360A683CA41DCEFC6F0" xlink:type="arc"/>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_7394EC100FD4AAA4C96AB7E28B5DB013_terseLabel_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Net [Rollforward] </link:label>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_7394EC100FD4AAA4C96AB7E28B5DB013_label_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax [Roll Forward] </link:label>
<link:label id="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_7394EC100FD4AAA4C96AB7E28B5DB013_documentation_en-US" xlink:label="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax [Roll Forward] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward" xlink:label="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:to="lab_opk_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetofTaxRollForward_B9C556DA0D0C50549B1029F28A02F9C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_D2F9396E2B0369FD8D31B7E28B5EBCAC_periodStartLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_DE3C673B604156BCADF62F43405086D7" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning Balance </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_D2F9396E2B0369FD8D31B7E28B5EBCAC_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_DE3C673B604156BCADF62F43405086D7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss), Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_DE3C673B604156BCADF62F43405086D7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_DE3C673B604156BCADF62F43405086D7" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_DE3C673B604156BCADF62F43405086D7" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_ED7CC11B81BFD2703468B7E28B5E6B13_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_A0FE0F08A2C7555CAEF8D430634F3AF8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income before reclassifications, net of tax </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_ED7CC11B81BFD2703468B7E28B5E6B13_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_A0FE0F08A2C7555CAEF8D430634F3AF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), before Reclassifications, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_A0FE0F08A2C7555CAEF8D430634F3AF8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_A0FE0F08A2C7555CAEF8D430634F3AF8" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_A0FE0F08A2C7555CAEF8D430634F3AF8" xlink:type="arc"/>
<link:label id="lab_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BE120E4256EA7DEF34BB7E28B5EDAB2_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_E795FB23BC195998A1CEF48DE23B57FA" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Amounts reclassified from accumulated other comprehensive income, net of tax </link:label>
<link:label id="lab_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BE120E4256EA7DEF34BB7E28B5EDAB2_label_en-US" xlink:label="lab_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_E795FB23BC195998A1CEF48DE23B57FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reclassification from Accumulated Other Comprehensive Income, Current Period, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_E795FB23BC195998A1CEF48DE23B57FA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_E795FB23BC195998A1CEF48DE23B57FA" xlink:to="lab_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_E795FB23BC195998A1CEF48DE23B57FA" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B9C521EC849E88EC0FB7E28B5EB13D_totalLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E106080604D6584EA3E093CC27D6F63C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net other comprehensive loss </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B9C521EC849E88EC0FB7E28B5EB13D_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E106080604D6584EA3E093CC27D6F63C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E106080604D6584EA3E093CC27D6F63C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E106080604D6584EA3E093CC27D6F63C" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E106080604D6584EA3E093CC27D6F63C" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_61FAF65A4EDCD9977F13B7E28B5EC027_periodEndLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_196FD1BFD28B582D9D9A151595E6F95E" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending Balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_196FD1BFD28B582D9D9A151595E6F95E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_196FD1BFD28B582D9D9A151595E6F95E" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_196FD1BFD28B582D9D9A151595E6F95E" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_B9DEF0D8740A01F8C8D7D632556122C6_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_EA7823A53C1A5B0F9C8F4C59883C9880" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_B9DEF0D8740A01F8C8D7D632556122C6_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_EA7823A53C1A5B0F9C8F4C59883C9880" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_EA7823A53C1A5B0F9C8F4C59883C9880" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_EA7823A53C1A5B0F9C8F4C59883C9880" xlink:to="lab_us-gaap_FairValueByMeasurementFrequencyAxis_EA7823A53C1A5B0F9C8F4C59883C9880" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_1DA14AE24177B2B28596D63255611C9F_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_7AA692AA14D056FE866EBE51285B77EC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_1DA14AE24177B2B28596D63255611C9F_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_7AA692AA14D056FE866EBE51285B77EC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_7AA692AA14D056FE866EBE51285B77EC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_7AA692AA14D056FE866EBE51285B77EC" xlink:to="lab_us-gaap_FairValueMeasurementFrequencyDomain_7AA692AA14D056FE866EBE51285B77EC" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_AD87F43E62DF48DBB8F6D63255615FC0_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_CE18226D502A5DFBB568A130A16E010C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurements, Recurring </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_AD87F43E62DF48DBB8F6D63255615FC0_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_CE18226D502A5DFBB568A130A16E010C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurements, Recurring [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_CE18226D502A5DFBB568A130A16E010C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsRecurringMember_CE18226D502A5DFBB568A130A16E010C" xlink:to="lab_us-gaap_FairValueMeasurementsRecurringMember_CE18226D502A5DFBB568A130A16E010C" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByAssetClassAxis_EE18D8B9575534552B26D63255615D29_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_2FE212AEC88F5260B22BEA9FD46335B8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Asset Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByAssetClassAxis_EE18D8B9575534552B26D63255615D29_label_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_2FE212AEC88F5260B22BEA9FD46335B8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Asset Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_2FE212AEC88F5260B22BEA9FD46335B8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_2FE212AEC88F5260B22BEA9FD46335B8" xlink:to="lab_us-gaap_FairValueByAssetClassAxis_2FE212AEC88F5260B22BEA9FD46335B8" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_CDFA9D0A6C45F5D5BFD2D6325561482D_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_9FBB06C3E7CC5EDCB9219F64E8A7B868" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Asset Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_CDFA9D0A6C45F5D5BFD2D6325561482D_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_9FBB06C3E7CC5EDCB9219F64E8A7B868" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Asset Class [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_9FBB06C3E7CC5EDCB9219F64E8A7B868" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_9FBB06C3E7CC5EDCB9219F64E8A7B868" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_9FBB06C3E7CC5EDCB9219F64E8A7B868" xlink:type="arc"/>
<link:label id="lab_us-gaap_MoneyMarketFundsMember_34C33CA5D0B439E97A49D63255613A18_verboseLabel_en-US" xlink:label="lab_us-gaap_MoneyMarketFundsMember_6394970EC7E158DF8C8F4826BCE84997" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Money market funds </link:label>
<link:label id="lab_us-gaap_MoneyMarketFundsMember_34C33CA5D0B439E97A49D63255613A18_label_en-US" xlink:label="lab_us-gaap_MoneyMarketFundsMember_6394970EC7E158DF8C8F4826BCE84997" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Money Market Funds [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_6394970EC7E158DF8C8F4826BCE84997" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MoneyMarketFundsMember_6394970EC7E158DF8C8F4826BCE84997" xlink:to="lab_us-gaap_MoneyMarketFundsMember_6394970EC7E158DF8C8F4826BCE84997" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_3A1066F331929E77A4BBD63255613FF9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_FF88B5A4D06157ECB3639ABE8262B74F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_3A1066F331929E77A4BBD63255613FF9_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_FF88B5A4D06157ECB3639ABE8262B74F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_FF88B5A4D06157ECB3639ABE8262B74F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_FF88B5A4D06157ECB3639ABE8262B74F" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis_FF88B5A4D06157ECB3639ABE8262B74F" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_54323665F695E2E7AF5ED632556137FA_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_19AD75E07CC75009A2CD429D0DF1F893" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_54323665F695E2E7AF5ED632556137FA_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_19AD75E07CC75009A2CD429D0DF1F893" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_19AD75E07CC75009A2CD429D0DF1F893" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_19AD75E07CC75009A2CD429D0DF1F893" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_19AD75E07CC75009A2CD429D0DF1F893" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_4DF44C1DCA3F84856985D6325561230A_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_2342BB48AE595C7F94C9D8315612C051" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_2342BB48AE595C7F94C9D8315612C051" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_2342BB48AE595C7F94C9D8315612C051" xlink:to="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_2342BB48AE595C7F94C9D8315612C051" xlink:type="arc"/>
<link:label id="lab_opk_ContingentConsiderationMember_86EC5D1A3DE804958E75D6325561FE2C_terseLabel_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_86EC5D1A3DE804958E75D6325561FE2C_label_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration [Member] </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_86EC5D1A3DE804958E75D6325561FE2C_documentation_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Contingent consideration. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ContingentConsiderationMember" xlink:label="loc_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:to="lab_opk_ContingentConsiderationMember_6076C3E006145860A0E568CEF3637569" xlink:type="arc"/>
<link:label id="lab_opk_OPKORenalMember_0BE4497EF670CE76D2E1D6325562C5A7_terseLabel_en-US" xlink:label="lab_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OPKORenalMember_0BE4497EF670CE76D2E1D6325562C5A7_label_en-US" xlink:label="lab_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Renal [Member] </link:label>
<link:label id="lab_opk_OPKORenalMember_0BE4497EF670CE76D2E1D6325562C5A7_documentation_en-US" xlink:label="lab_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Renal [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKORenalMember" xlink:label="loc_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:to="lab_opk_OPKORenalMember_1152D572D1FD54B1B7B1AC5E04F2C266" xlink:type="arc"/>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_56016E6B3DD54355B944D63255623DAA_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_44613AA13E8159968CCA98EE33A066B6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Assets: </link:label>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_56016E6B3DD54355B944D63255623DAA_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_44613AA13E8159968CCA98EE33A066B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial Instruments, Financial Assets, Balance Sheet Groupings [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_44613AA13E8159968CCA98EE33A066B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_44613AA13E8159968CCA98EE33A066B6" xlink:to="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_44613AA13E8159968CCA98EE33A066B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_5A355340C4D6937226E8D63255624DD7_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_B733C1F7D97557ACA1CF8A7A67E543C8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_5A355340C4D6937226E8D63255624DD7_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_B733C1F7D97557ACA1CF8A7A67E543C8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_B733C1F7D97557ACA1CF8A7A67E543C8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_B733C1F7D97557ACA1CF8A7A67E543C8" xlink:to="lab_us-gaap_AssetsFairValueDisclosure_B733C1F7D97557ACA1CF8A7A67E543C8" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_87D61A6AF3E3E5B35910D6325562CEA7_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_BBBA27958485543F93EDE4AECB4CACA5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_87D61A6AF3E3E5B35910D6325562CEA7_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_BBBA27958485543F93EDE4AECB4CACA5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Fair Value Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_BBBA27958485543F93EDE4AECB4CACA5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_BBBA27958485543F93EDE4AECB4CACA5" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_BBBA27958485543F93EDE4AECB4CACA5" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_DB32E4F4E9BF430E0D91D6325562741A_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_E82DAA36D29B5FB3A732A53FE706348A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_DB32E4F4E9BF430E0D91D6325562741A_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_E82DAA36D29B5FB3A732A53FE706348A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial and Nonfinancial Liabilities, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_E82DAA36D29B5FB3A732A53FE706348A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_E82DAA36D29B5FB3A732A53FE706348A" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure_E82DAA36D29B5FB3A732A53FE706348A" xlink:type="arc"/>
<link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_03DDA8B4D00FFA25873D6BE734B08FCF_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_09C83E15DFDF51D18AED07E18C1A19BD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COMPOSITION OF CERTAIN FINANCIAL STATEMENT CAPTIONS </link:label>
<link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_03DDA8B4D00FFA25873D6BE734B08FCF_label_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_09C83E15DFDF51D18AED07E18C1A19BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Balance Sheet Disclosures [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_09C83E15DFDF51D18AED07E18C1A19BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_09C83E15DFDF51D18AED07E18C1A19BD" xlink:to="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_09C83E15DFDF51D18AED07E18C1A19BD" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Earnings Per Share </link:label>
<link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E" xlink:to="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_D7A9ABF98B012701C92486B1E11AB16E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ASSETS </link:label>
<link:label id="lab_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098" xlink:to="lab_us-gaap_AssetsAbstract_DCB66D617BBA4508A119ECDF93577098" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current assets: </link:label>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F_label_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F" xlink:to="lab_us-gaap_AssetsCurrentAbstract_D97F54B8E49CDF911CFCECDF93571F9F" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, at Carrying Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_4B3BD416188D7C3C584DECDF9357FAF0" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNet_6230E1CE994C9938F4EAECDF93577501_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_6230E1CE994C9938F4EAECDF93577501" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventory, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_6230E1CE994C9938F4EAECDF93577501" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet_6230E1CE994C9938F4EAECDF93577501" xlink:to="lab_us-gaap_InventoryNet_6230E1CE994C9938F4EAECDF93577501" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_FEBF65E557FA5549450EECDF93575F1E_verboseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_FEBF65E557FA5549450EECDF93575F1E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_FEBF65E557FA5549450EECDF93575F1E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_FEBF65E557FA5549450EECDF93575F1E" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_FEBF65E557FA5549450EECDF93575F1E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current assets </link:label>
<link:label id="lab_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66_label_en-US" xlink:label="lab_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66" xlink:to="lab_us-gaap_AssetsCurrent_DC7188174C4AE05F5021ECDF93576C66" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7_verboseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, net </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentNet_4B436638C1CBF436B653ECDF9357EAE7" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_4596CE4EC7B9B2440F8CECDF935719FB_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_4596CE4EC7B9B2440F8CECDF935719FB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4596CE4EC7B9B2440F8CECDF935719FB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4596CE4EC7B9B2440F8CECDF935719FB" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet_4596CE4EC7B9B2440F8CECDF935719FB" xlink:type="arc"/>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D_verboseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> In-process research and development </link:label>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Indefinite-Lived Intangible Assets (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_E69BC7892D39AC842A1BECDF9357DC3D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7_verboseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:label id="lab_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7_label_en-US" xlink:label="lab_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7" xlink:to="lab_us-gaap_Goodwill_D4D2E9947D6C98EB5AB9ECDF93574BB7" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermInvestments_89EEC598A70A97408129ECDF9357465A_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_89EEC598A70A97408129ECDF9357465A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_89EEC598A70A97408129ECDF9357465A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermInvestments_89EEC598A70A97408129ECDF9357465A" xlink:to="lab_us-gaap_LongTermInvestments_89EEC598A70A97408129ECDF9357465A" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other assets, principally deferred tax assets </link:label>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9_label_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9" xlink:to="lab_us-gaap_OtherAssetsNoncurrent_E6F8E4E9682EFD12B67AECDF9358B5E9" xlink:type="arc"/>
<link:label id="lab_us-gaap_Assets_46949601817CDAEF339AECDF9358919C_totalLabel_en-US" xlink:label="lab_us-gaap_Assets_46949601817CDAEF339AECDF9358919C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_Assets_46949601817CDAEF339AECDF9358919C_label_en-US" xlink:label="lab_us-gaap_Assets_46949601817CDAEF339AECDF9358919C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_46949601817CDAEF339AECDF9358919C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_46949601817CDAEF339AECDF9358919C" xlink:to="lab_us-gaap_Assets_46949601817CDAEF339AECDF9358919C" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> LIABILITIES AND EQUITY </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A5033209405FD5B955ECECDF9358F7D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275" xlink:to="lab_us-gaap_LiabilitiesCurrentAbstract_1B79950A4FC9C8F3D27AECDF93584275" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7_label_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Payable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7" xlink:to="lab_us-gaap_AccountsPayableCurrent_D744F60191C5D68D8EC7ECDF93586ED7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_8CC65BB6D0ECDA28F6E9ECDF93586BA7_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_8CC65BB6D0ECDA28F6E9ECDF93586BA7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_8CC65BB6D0ECDA28F6E9ECDF93586BA7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_8CC65BB6D0ECDA28F6E9ECDF93586BA7" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrent_8CC65BB6D0ECDA28F6E9ECDF93586BA7" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtCurrent_EBF262F99AFA10BEE0C2ECDF93583AC3_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_EBF262F99AFA10BEE0C2ECDF93583AC3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of lines of credit and notes payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_EBF262F99AFA10BEE0C2ECDF93583AC3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtCurrent_EBF262F99AFA10BEE0C2ECDF93583AC3" xlink:to="lab_us-gaap_LongTermDebtCurrent_EBF262F99AFA10BEE0C2ECDF93583AC3" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36" xlink:to="lab_us-gaap_LiabilitiesCurrent_D490641A3D76F614D3BBECDF93580F36" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, net of discount and estimated fair value of embedded derivatives </link:label>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D_label_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D" xlink:to="lab_us-gaap_ConvertibleLongTermNotesPayable_E7A1AF97791971571DFEECDF9358044D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liabilities </link:label>
<link:label id="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Tax Liabilities, Net, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F" xlink:to="lab_us-gaap_DeferredTaxLiabilitiesNoncurrent_845FDE943D92EDB6113BECDF9358587F" xlink:type="arc"/>
<link:label id="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80_verboseLabel_en-US" xlink:label="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities, principally deferred revenue and contingent consideration </link:label>
<link:label id="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80_label_en-US" xlink:label="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Deferred Revenue and Contingent Consideration, Noncurrent </link:label>
<link:label id="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80_documentation_en-US" xlink:label="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Other Liabilities, Deferred Revenue and Contingent Consideration, Noncurrent </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent" xlink:label="loc_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:to="lab_opk_OtherLiabilitiesDeferredRevenueandContingentConsiderationNoncurrent_F30A7750E12BFE816F46ECDF93585F80" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total long-term liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489_label_en-US" xlink:label="lab_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489" xlink:to="lab_us-gaap_LiabilitiesNoncurrent_8C7BA7D1098904CA117DECDF93584489" xlink:type="arc"/>
<link:label id="lab_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF_label_en-US" xlink:label="lab_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF" xlink:to="lab_us-gaap_Liabilities_1590B7168DF325B9D494ECDF9358C2CF" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity: </link:label>
<link:label id="lab_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084" xlink:to="lab_us-gaap_StockholdersEquityAbstract_2EF8691512C4DC698EDBECDF9358E084" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock - $0.01 par value, 750,000,000 shares authorized; 545,951,707 and 433,421,677 shares issued at September 30, 2015 and December 31, 2014, respectively </link:label>
<link:label id="lab_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3_label_en-US" xlink:label="lab_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Value, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3" xlink:to="lab_us-gaap_CommonStockValue_B5764808A10D957CA739ECDF935839A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625_negatedLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Treasury Stock - 1,120,367 and 1,245,367 shares at September 30, 2015 and December 31, 2014, respectively </link:label>
<link:label id="lab_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625_label_en-US" xlink:label="lab_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock, Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625" xlink:to="lab_us-gaap_TreasuryStockValue_EBD0A66A049D4C352BEBECDF93581625" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88_verboseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Additional paid-in capital </link:label>
<link:label id="lab_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Additional Paid in Capital </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88" xlink:to="lab_us-gaap_AdditionalPaidInCapital_F7179B57D6A4D52D3175ECDF93594D88" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FC5F05E49869147C8F45ECDF93592998_verboseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FC5F05E49869147C8F45ECDF93592998" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated other comprehensive income (loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FC5F05E49869147C8F45ECDF93592998" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FC5F05E49869147C8F45ECDF93592998" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FC5F05E49869147C8F45ECDF93592998" xlink:type="arc"/>
<link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676_verboseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated deficit </link:label>
<link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retained Earnings (Accumulated Deficit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676" xlink:to="lab_us-gaap_RetainedEarningsAccumulatedDeficit_0EDCF71A6F475E6753C4ECDF93595676" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total shareholders’ equity attributable to OPKO </link:label>
<link:label id="lab_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68" xlink:to="lab_us-gaap_StockholdersEquity_2EAD190078273C260418ECDF9359DA68" xlink:type="arc"/>
<link:label id="lab_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F_verboseLabel_en-US" xlink:label="lab_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Noncontrolling interests </link:label>
<link:label id="lab_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F_label_en-US" xlink:label="lab_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F" xlink:to="lab_us-gaap_MinorityInterest_1500DA162403D7B138CDECDF9359848F" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total shareholders’ equity </link:label>
<link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC" xlink:to="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FDC5D3BAB3B343243662ECDF9359D8AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities and equity </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquity_52BE7ED7773173F6DA53ECDF9359B889" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Purchase Price Allocation </link:label>
<link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Business Acquisitions, by Acquisition [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTextBlock_CB09BA2C44160058C9B286CF3BE2EBC1" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Pro Forma </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Information [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979" xlink:to="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_9C82E316B1376CF66B1E86CF3BE2E979" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6_verboseLabel_en-US" xlink:label="lab_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maximum exposure of unconsolidated investments </link:label>
<link:label id="lab_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6_label_en-US" xlink:label="lab_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentTableTextBlock" xlink:label="loc_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6" xlink:to="lab_invest_InvestmentTableTextBlock_A1F54D688F4E6BA0D84186CF3BE293D6" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of consolidated assets and non-recourse liabilities related to SciVac </link:label>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F_label_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTextBlock" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F" xlink:to="lab_us-gaap_ScheduleOfVariableInterestEntitiesTextBlock_E9074532705AE62EB48286CF3BE2C49F" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_99FE064375A2B3B6A68DA50A07F4DDDF_label_en-US" xlink:label="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_99FE064375A2B3B6A68DA50A07F4DDDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Comprehensive Income [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_99FE064375A2B3B6A68DA50A07F4DDDF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_99FE064375A2B3B6A68DA50A07F4DDDF" xlink:to="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_99FE064375A2B3B6A68DA50A07F4DDDF" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_68FA22B4187BB734E670A50A07F43953_terseLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_68FA22B4187BB734E670A50A07F43953" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_68FA22B4187BB734E670A50A07F43953" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_68FA22B4187BB734E670A50A07F43953" xlink:to="lab_us-gaap_ProfitLoss_68FA22B4187BB734E670A50A07F43953" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income (loss), net of tax: </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_15DCBDB2F0CFC32B8720A50A07F4C130" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in foreign currency translation and other comprehensive income (loss) from equity investments </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_DD6F02CD9CB61C5BCB8AA50A07F43E5F" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Available for sale investments: </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80" xlink:to="lab_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParentAbstract_2A1395DE4412D6D98C1AA50A07F41C80" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in unrealized gain (loss), net of tax </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF" xlink:to="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_514C292EE624B987550CA50A07F487EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Less: reclassification adjustments for (gains) losses included in net income (loss), net of tax </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_226E865226D7E59F2DBAA50A07F4CCC8" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Comprehensive loss </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_D30E0F5AD261587CA558A50A07F481F4" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Less: Comprehensive loss attributable to noncontrolling interest </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2AF023AB32C6B8CC59BCA50A07F46A36" xlink:type="arc"/>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Comprehensive income (loss) attributable to common shareholders </link:label>
<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Comprehensive Income (Loss), Net of Tax, Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTax_9158E1E79A87CDF913E1A50A07F4EE04" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentTable_858B67F44ACED7588F99C1301D504A89_terseLabel_en-US" xlink:label="lab_invest_InvestmentTable_A006045793CF5E63AD11E02862E1EBA3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Table] </link:label>
<link:label id="lab_invest_InvestmentTable_858B67F44ACED7588F99C1301D504A89_label_en-US" xlink:label="lab_invest_InvestmentTable_A006045793CF5E63AD11E02862E1EBA3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Table] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentTable" xlink:label="loc_invest_InvestmentTable_A006045793CF5E63AD11E02862E1EBA3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentTable_A006045793CF5E63AD11E02862E1EBA3" xlink:to="lab_invest_InvestmentTable_A006045793CF5E63AD11E02862E1EBA3" xlink:type="arc"/>
<link:label id="lab_opk_ChromaDexMember_C738C762CE359A3D3F6FC1301D502DED_terseLabel_en-US" xlink:label="lab_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ChromaDex </link:label>
<link:label id="lab_opk_ChromaDexMember_C738C762CE359A3D3F6FC1301D502DED_label_en-US" xlink:label="lab_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ChromaDex [Member] </link:label>
<link:label id="lab_opk_ChromaDexMember_C738C762CE359A3D3F6FC1301D502DED_documentation_en-US" xlink:label="lab_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> ChromaDex. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ChromaDexMember" xlink:label="loc_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:to="lab_opk_ChromaDexMember_57A28660502A5F77B64BC401D0426108" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherIncomeMember_35B583D855DA7665586BC1301D51E4FB_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIncomeMember_D86F1F3449905D9C9A09008D95F4216C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Income </link:label>
<link:label id="lab_us-gaap_OtherIncomeMember_35B583D855DA7665586BC1301D51E4FB_label_en-US" xlink:label="lab_us-gaap_OtherIncomeMember_D86F1F3449905D9C9A09008D95F4216C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Income [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherIncomeMember" xlink:label="loc_us-gaap_OtherIncomeMember_D86F1F3449905D9C9A09008D95F4216C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherIncomeMember_D86F1F3449905D9C9A09008D95F4216C" xlink:to="lab_us-gaap_OtherIncomeMember_D86F1F3449905D9C9A09008D95F4216C" xlink:type="arc"/>
<link:label id="lab_invest_InvestmentLineItems_3B5E325CD3DF0D073D85C1301D51D3A4_terseLabel_en-US" xlink:label="lab_invest_InvestmentLineItems_E2A2AB3FFFDB5E46B407B645F3D81753" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Line Items] </link:label>
<link:label id="lab_invest_InvestmentLineItems_3B5E325CD3DF0D073D85C1301D51D3A4_label_en-US" xlink:label="lab_invest_InvestmentLineItems_E2A2AB3FFFDB5E46B407B645F3D81753" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentLineItems" xlink:label="loc_invest_InvestmentLineItems_E2A2AB3FFFDB5E46B407B645F3D81753" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentLineItems_E2A2AB3FFFDB5E46B407B645F3D81753" xlink:to="lab_invest_InvestmentLineItems_E2A2AB3FFFDB5E46B407B645F3D81753" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_27888E927D2F090F76BBC1301D513079_terseLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_27888E927D2F090F76BBC1301D513079_label_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_27888E927D2F090F76BBC1301D513079_documentation_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:to="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D55B4AE9CE6654C9AA913AB69DEFA66C" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_0F0418523F09F3760EF5C1301D510F16_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_866AFF8F8C165AC8AB251085CEC0B213" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain (loss) on sale of investments </link:label>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_0F0418523F09F3760EF5C1301D510F16_label_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_866AFF8F8C165AC8AB251085CEC0B213" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Sale of Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_866AFF8F8C165AC8AB251085CEC0B213" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSaleOfInvestments_866AFF8F8C165AC8AB251085CEC0B213" xlink:to="lab_us-gaap_GainLossOnSaleOfInvestments_866AFF8F8C165AC8AB251085CEC0B213" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingDisclosureTextBlock_08438D6A24963CB68D7C6BE7352718AB_verboseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingDisclosureTextBlock_4C562BD9C5C550E3AC5BC4D23058234F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SEGMENTS </link:label>
<link:label id="lab_us-gaap_SegmentReportingDisclosureTextBlock_08438D6A24963CB68D7C6BE7352718AB_label_en-US" xlink:label="lab_us-gaap_SegmentReportingDisclosureTextBlock_4C562BD9C5C550E3AC5BC4D23058234F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingDisclosureTextBlock" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_4C562BD9C5C550E3AC5BC4D23058234F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingDisclosureTextBlock_4C562BD9C5C550E3AC5BC4D23058234F" xlink:to="lab_us-gaap_SegmentReportingDisclosureTextBlock_4C562BD9C5C550E3AC5BC4D23058234F" xlink:type="arc"/>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F_terseLabel_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Currently marketed products </link:label>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F_label_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products [Member] </link:label>
<link:label id="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F_documentation_en-US" xlink:label="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Currently Marketed Products [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CurrentlyMarketedProductsMember" xlink:label="loc_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:to="lab_opk_CurrentlyMarketedProductsMember_63EB76E5ACFF751F5A50D9DAF3BA9F1F" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Value of OPKO Common Stock issued to Bio-Reference shareholders </link:label>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred, Equity Interests Issued and Issuable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403" xlink:to="lab_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_138DDF823655B811932BD9DAF3BAA403" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Less: Equity issuance costs </link:label>
<link:label id="lab_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Separately Recognized Transactions, Additional Disclosures, Issuance Costs Not Expensed </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed" xlink:label="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96" xlink:to="lab_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresIssuanceCostsNotExpensed_E660FFB1CA0BE309B967D9DAF3BAAD96" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3B7E8C5EF68C17AA7A56D9DAF3BA662E" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Receivables </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_4631A6D995D4FCC37FD5D9DAF3BA95A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inventory </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_4F2F6547273BF9BD5179D9DAF3BB0602" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other current assets, principally deferred tax assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Other </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_FBE1DD8D854B1529DB26D9DAF3BBFC4D" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_8ED7D418F48CD252C724D9DAF3BBA6BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6D1C8E4C54526EBCF45CD9DAF3BB46CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_A95B5B5847CF6945B728D9DAF3BB739D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_02F120EA98A846B18BD9D9DAF3BBD1A4_terseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_02F120EA98A846B18BD9D9DAF3BBD1A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_02F120EA98A846B18BD9D9DAF3BBD1A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_02F120EA98A846B18BD9D9DAF3BBD1A4" xlink:to="lab_us-gaap_Goodwill_02F120EA98A846B18BD9D9DAF3BBD1A4" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Investments </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Investments </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_E32B4582917879098007D9DAF3BB5A89" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Noncurrent Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_04DB886E8C51C7AE093BD9DAF3BB9A90" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036_totalLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1E84A5AE3A44B1C89436D9DAF3BBB036" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_E28988A4152BC5D8F770D9DAF3BB2730" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F_negatedTerseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accrued Expenses </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accrued Expenses </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_BBB38754F0F9599073FED9DAF3BBA07F" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9_negatedTerseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes payable </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Income Taxes Payable </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Income Taxes Payable </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesIncomeTaxesPayable_DB091090F1779EC47667D9DAF3BBC7C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Lines of credit and notes payable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_060C67EC50829840EEF4D9DAF3BB0299" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Capital lease obligations </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Capital Lease Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_22D0E137F4565B9C8B4FD9DAF3BB9B2A" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6_negatedLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable and other liabilities </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable and Other Current Liabilities </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable and Other Current Liabilities </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:to="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities_38D819AE334E099C4784D9DAF3BBF4B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D_negatedLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liability (non-current) </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_DEF0A4B81FB7748017F1D9DAF3BBE55D" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total purchase price </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_77B8A540FAA4BD13C28ED9DAF3BB3EE0" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_E32D2CB6BF3E66170EAAD0F8202BF089_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_E32D2CB6BF3E66170EAAD0F8202BF089_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_E32D2CB6BF3E66170EAAD0F8202BF089_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_F00D3D7C372A55ABA5D56B8A49E3088F" xlink:type="arc"/>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_142661F97B05500B4C7ED0F8202C47FC_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_142661F97B05500B4C7ED0F8202C47FC_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_142661F97B05500B4C7ED0F8202C47FC_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> [Line Items] for Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_6329FCAB1F9C5809B6D43CDF6DF196CF" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_6DF46389E1D0259CA13BD0F8202C8EE0_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_BF003C5AEAC0533D8BCA80C9787A6FC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_6DF46389E1D0259CA13BD0F8202C8EE0_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_BF003C5AEAC0533D8BCA80C9787A6FC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_BF003C5AEAC0533D8BCA80C9787A6FC8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_BF003C5AEAC0533D8BCA80C9787A6FC8" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_BF003C5AEAC0533D8BCA80C9787A6FC8" xlink:type="arc"/>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_3C80BD9846391D444277D0F8202CDF21_terseLabel_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total losses (gains) for the period: </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_3C80BD9846391D444277D0F8202CDF21_label_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) [Abstract] </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_3C80BD9846391D444277D0F8202CDF21_documentation_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) [Abstract] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:to="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract_AF4A06DB49B1544091AEB7C1141D683A" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_DEE730177B5F245F360BD0F8202CAE16_periodStartLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_2D3CF60CE69A5EBDA78897AF06790F31" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning Balance </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_DEE730177B5F245F360BD0F8202CAE16_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_2D3CF60CE69A5EBDA78897AF06790F31" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_2D3CF60CE69A5EBDA78897AF06790F31" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_2D3CF60CE69A5EBDA78897AF06790F31" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_2D3CF60CE69A5EBDA78897AF06790F31" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_63F246D44DC1EC46C21BD0F8202CA174_negatedLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_0D7B22F987D45FE583733BDF2438CD7F" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Included in results of operations </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_63F246D44DC1EC46C21BD0F8202CA174_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_0D7B22F987D45FE583733BDF2438CD7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_0D7B22F987D45FE583733BDF2438CD7F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_0D7B22F987D45FE583733BDF2438CD7F" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_0D7B22F987D45FE583733BDF2438CD7F" xlink:type="arc"/>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_FBB0957039399DC9B763D0F8202CB3AC_negatedTerseLabel_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency impact </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_FBB0957039399DC9B763D0F8202CB3AC_label_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_FBB0957039399DC9B763D0F8202CB3AC_documentation_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:to="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_9AF1169679185EDD9DD2E31E84B82145" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_55C5AE4158BC36A4CEE7D0F963A316AA_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_AF2CDA97A471547A87DA9D465EA95DE7" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Payments </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_55C5AE4158BC36A4CEE7D0F963A316AA_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_AF2CDA97A471547A87DA9D465EA95DE7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_AF2CDA97A471547A87DA9D465EA95DE7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_AF2CDA97A471547A87DA9D465EA95DE7" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_AF2CDA97A471547A87DA9D465EA95DE7" xlink:type="arc"/>
<link:label id="lab_opk_DebtConversionEmbeddedDerivativeAmount_B638AEB44AE74BB353B0D0F8202C7A1C_negatedLabel_en-US" xlink:label="lab_opk_DebtConversionEmbeddedDerivativeAmount_1395F70724AD55C4B8DD3DDC5E6BEE6F" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Conversion </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DebtConversionEmbeddedDerivativeAmount" xlink:label="loc_opk_DebtConversionEmbeddedDerivativeAmount_1395F70724AD55C4B8DD3DDC5E6BEE6F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtConversionEmbeddedDerivativeAmount_1395F70724AD55C4B8DD3DDC5E6BEE6F" xlink:to="lab_opk_DebtConversionEmbeddedDerivativeAmount_1395F70724AD55C4B8DD3DDC5E6BEE6F" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_01D495511CCBFEDE4788D0F8202C5A4E_periodEndLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6B5C15527C4C54ED82C0BB86FFF76F12" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending Balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6B5C15527C4C54ED82C0BB86FFF76F12" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6B5C15527C4C54ED82C0BB86FFF76F12" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6B5C15527C4C54ED82C0BB86FFF76F12" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_A465E365AECA5876C37AD92F32850FBA_verboseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_A465E365AECA5876C37AD92F32850FBA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_A465E365AECA5876C37AD92F32850FBA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_A465E365AECA5876C37AD92F32850FBA" xlink:to="lab_opk_DiagnosticsMember_A465E365AECA5876C37AD92F32850FBA" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating Segments </link:label>
<link:label id="lab_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F_label_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Segments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F" xlink:to="lab_us-gaap_OperatingSegmentsMember_AE7E7D30489EAF3C16DDD92F328BA95F" xlink:type="arc"/>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00_terseLabel_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate </link:label>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00_label_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corporate, Non-Segment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00" xlink:to="lab_us-gaap_CorporateNonSegmentMember_9D95F2CF047FFA86F176D92F328B4E00" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298_terseLabel_en-US" xlink:label="lab_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reconciling Items </link:label>
<link:label id="lab_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298_label_en-US" xlink:label="lab_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reconciling Items [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaterialReconcilingItemsMember" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298" xlink:to="lab_us-gaap_MaterialReconcilingItemsMember_837342C7C20F65C1B513D92F328BF298" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A_terseLabel_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:label id="lab_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A_label_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A" xlink:to="lab_us-gaap_StatementGeographicalAxis_37DDE06DC16E86D09A70D92F328B3B4A" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873_label_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873" xlink:to="lab_us-gaap_SegmentGeographicalDomain_3D6375212CF6DC7D9E7BD92F328B5873" xlink:type="arc"/>
<link:label id="lab_country_US_213A6607EBC7A12E4F05D92F328B46FE_verboseLabel_en-US" xlink:label="lab_country_US_213A6607EBC7A12E4F05D92F328B46FE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> United States </link:label>
<link:label id="lab_country_US_213A6607EBC7A12E4F05D92F328B46FE_label_en-US" xlink:label="lab_country_US_213A6607EBC7A12E4F05D92F328B46FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> UNITED STATES </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_213A6607EBC7A12E4F05D92F328B46FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_US_213A6607EBC7A12E4F05D92F328B46FE" xlink:to="lab_country_US_213A6607EBC7A12E4F05D92F328B46FE" xlink:type="arc"/>
<link:label id="lab_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26_terseLabel_en-US" xlink:label="lab_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ireland </link:label>
<link:label id="lab_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26_label_en-US" xlink:label="lab_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> IRELAND </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_IE" xlink:label="loc_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26" xlink:to="lab_country_IE_6BDD052ACBF8BA08D7D7D92F328B1F26" xlink:type="arc"/>
<link:label id="lab_country_CL_24B548DF1B86D7AC4559D92F328B4F6C_verboseLabel_en-US" xlink:label="lab_country_CL_24B548DF1B86D7AC4559D92F328B4F6C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Chile </link:label>
<link:label id="lab_country_CL_24B548DF1B86D7AC4559D92F328B4F6C_label_en-US" xlink:label="lab_country_CL_24B548DF1B86D7AC4559D92F328B4F6C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CHILE </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_CL" xlink:label="loc_country_CL_24B548DF1B86D7AC4559D92F328B4F6C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_CL_24B548DF1B86D7AC4559D92F328B4F6C" xlink:to="lab_country_CL_24B548DF1B86D7AC4559D92F328B4F6C" xlink:type="arc"/>
<link:label id="lab_country_ES_90BD600708E20880A700D92F328BEE05_verboseLabel_en-US" xlink:label="lab_country_ES_90BD600708E20880A700D92F328BEE05" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Spain </link:label>
<link:label id="lab_country_ES_90BD600708E20880A700D92F328BEE05_label_en-US" xlink:label="lab_country_ES_90BD600708E20880A700D92F328BEE05" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SPAIN </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_ES" xlink:label="loc_country_ES_90BD600708E20880A700D92F328BEE05" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_ES_90BD600708E20880A700D92F328BEE05" xlink:to="lab_country_ES_90BD600708E20880A700D92F328BEE05" xlink:type="arc"/>
<link:label id="lab_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03_verboseLabel_en-US" xlink:label="lab_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Israel </link:label>
<link:label id="lab_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03_label_en-US" xlink:label="lab_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ISRAEL </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_IL" xlink:label="loc_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03" xlink:to="lab_country_IL_94BC2052CF1D6DFD9B01D92F328BDB03" xlink:type="arc"/>
<link:label id="lab_country_MX_8FB5A2FACD1C2434D275D92F328C33DC_verboseLabel_en-US" xlink:label="lab_country_MX_8FB5A2FACD1C2434D275D92F328C33DC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mexico </link:label>
<link:label id="lab_country_MX_8FB5A2FACD1C2434D275D92F328C33DC_label_en-US" xlink:label="lab_country_MX_8FB5A2FACD1C2434D275D92F328C33DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MEXICO </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_MX" xlink:label="loc_country_MX_8FB5A2FACD1C2434D275D92F328C33DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_MX_8FB5A2FACD1C2434D275D92F328C33DC" xlink:to="lab_country_MX_8FB5A2FACD1C2434D275D92F328C33DC" xlink:type="arc"/>
<link:label id="lab_country_UY_4218F4D4437628126FC5D92F328CB603_terseLabel_en-US" xlink:label="lab_country_UY_4218F4D4437628126FC5D92F328CB603" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_country_UY_4218F4D4437628126FC5D92F328CB603_label_en-US" xlink:label="lab_country_UY_4218F4D4437628126FC5D92F328CB603" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> URUGUAY </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_UY" xlink:label="loc_country_UY_4218F4D4437628126FC5D92F328CB603" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_UY_4218F4D4437628126FC5D92F328CB603" xlink:to="lab_country_UY_4218F4D4437628126FC5D92F328CB603" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_A6E955078A456D595887D92F328C26BA_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_A6E955078A456D595887D92F328C26BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_A6E955078A456D595887D92F328C26BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_A6E955078A456D595887D92F328C26BA" xlink:to="lab_us-gaap_SalesRevenueServicesNet_A6E955078A456D595887D92F328C26BA" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_644C02E4D1DDA4A72321D92F328C06AD_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_644C02E4D1DDA4A72321D92F328C06AD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_644C02E4D1DDA4A72321D92F328C06AD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueGoodsNet_644C02E4D1DDA4A72321D92F328C06AD" xlink:to="lab_us-gaap_SalesRevenueGoodsNet_644C02E4D1DDA4A72321D92F328C06AD" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_B15B6BE2CE671A559467D92F328C2522_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_B15B6BE2CE671A559467D92F328C2522" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating (loss) income </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_B15B6BE2CE671A559467D92F328C2522" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingIncomeLoss_B15B6BE2CE671A559467D92F328C2522" xlink:to="lab_us-gaap_OperatingIncomeLoss_B15B6BE2CE671A559467D92F328C2522" xlink:type="arc"/>
<link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9_verboseLabel_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Depreciation and amortization </link:label>
<link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9_label_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Depreciation, Depletion and Amortization </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9" xlink:to="lab_us-gaap_DepreciationDepletionAndAmortization_8F2E325BBF125B8FCDF4D92F328C4FE9" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net loss from investment in investees </link:label>
<link:label id="lab_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8_label_en-US" xlink:label="lab_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8" xlink:to="lab_us-gaap_GainLossOnInvestments_BAE123F8E7971EDA4750D92F328CE0A8" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNet_EBAFFB7CE6ACE4FA41F3D92F328C5561_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_EBAFFB7CE6ACE4FA41F3D92F328C5561" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_EBAFFB7CE6ACE4FA41F3D92F328C5561" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNet_EBAFFB7CE6ACE4FA41F3D92F328C5561" xlink:to="lab_us-gaap_SalesRevenueNet_EBAFFB7CE6ACE4FA41F3D92F328C5561" xlink:type="arc"/>
<link:label id="lab_us-gaap_Assets_5E5CD3837733797298CDD92F328C3977_terseLabel_en-US" xlink:label="lab_us-gaap_Assets_5E5CD3837733797298CDD92F328C3977" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_5E5CD3837733797298CDD92F328C3977" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_5E5CD3837733797298CDD92F328C3977" xlink:to="lab_us-gaap_Assets_5E5CD3837733797298CDD92F328C3977" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_FD88554CCC59E354548F6BE734EC3193_verboseLabel_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_4971D5F197E555718DDB075B444FAC84" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COMMITMENTS AND CONTINGENCIES </link:label>
<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_FD88554CCC59E354548F6BE734EC3193_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_4971D5F197E555718DDB075B444FAC84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Commitments and Contingencies Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_4971D5F197E555718DDB075B444FAC84" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_4971D5F197E555718DDB075B444FAC84" xlink:to="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_4971D5F197E555718DDB075B444FAC84" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock Conversion Description [Axis] </link:label>
<link:label id="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Conversion Description [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8" xlink:to="lab_us-gaap_ConversionOfStockByUniqueDescriptionAxis_F28F441A0C140D877581DE134A3505D8" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Name [Domain] </link:label>
<link:label id="lab_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConversionOfStockNameDomain" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A" xlink:to="lab_us-gaap_ConversionOfStockNameDomain_A0CB442D720D3CEDD336DE134A35DD6A" xlink:type="arc"/>
<link:label id="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC_terseLabel_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion of Senior Notes </link:label>
<link:label id="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC_label_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Senior Notes [Member] </link:label>
<link:label id="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC_documentation_en-US" xlink:label="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Conversion of Senior Notes [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ConversionofSeniorNotesMember" xlink:label="loc_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:to="lab_opk_ConversionofSeniorNotesMember_558077D4F8C52D5CE75BDE134A35B2DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisitions by Unique Description [Axis] </link:label>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B_label_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisitions by Unique Description [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B" xlink:to="lab_us-gaap_NoncashOrPartNoncashAcquisitionsByUniqueDescriptionAxis_7D4531317F41C5990E11DE134A35EA6B" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3_label_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNameDomain" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3" xlink:to="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_24033FCC5F5B8ADF14D0DE134A35D3C3" xlink:type="arc"/>
<link:label id="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5_terseLabel_en-US" xlink:label="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Uruguay Ltda. </link:label>
<link:label id="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5_label_en-US" xlink:label="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Uruguay Ltda. [Member] </link:label>
<link:label id="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5_documentation_en-US" xlink:label="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Uruguay Ltda. [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKOUruguayLtda.Member" xlink:label="loc_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:to="lab_opk_OPKOUruguayLtda.Member_B31F588A43C0519FCC6ADE134A3512C5" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from operating activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_C639C5C708D4EA73ED0ADE134A35F3BD" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_089E23F6DF997236A282DE134A357E6E_verboseLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_089E23F6DF997236A282DE134A357E6E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Net loss </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_089E23F6DF997236A282DE134A357E6E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_089E23F6DF997236A282DE134A357E6E" xlink:to="lab_us-gaap_ProfitLoss_089E23F6DF997236A282DE134A357E6E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Adjustments to reconcile net loss to net cash used in operating activities: </link:label>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69_label_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69" xlink:to="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_6EFD77B393D0CA0EE1A8DE134A35AC69" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206_verboseLabel_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash interest on 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206_label_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Paid-in-Kind Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaidInKindInterest" xlink:label="loc_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206" xlink:to="lab_us-gaap_PaidInKindInterest_258ECE851149175E2C47DE134A36B206" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of deferred financing costs </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Financing Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_FCEFCE5B1429CB675ABFDE134A360C73" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_DDDA15D9EB5C9844E998DE134A365DA2_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_DDDA15D9EB5C9844E998DE134A365DA2" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Losses from investments in investees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_DDDA15D9EB5C9844E998DE134A365DA2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments_DDDA15D9EB5C9844E998DE134A365DA2" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments_DDDA15D9EB5C9844E998DE134A365DA2" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_D3042773A77EF3AD7CA4DE134A36C8DC_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_D3042773A77EF3AD7CA4DE134A36C8DC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation – employees and non-employees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_D3042773A77EF3AD7CA4DE134A36C8DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_D3042773A77EF3AD7CA4DE134A36C8DC" xlink:to="lab_us-gaap_ShareBasedCompensation_D3042773A77EF3AD7CA4DE134A36C8DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA_verboseLabel_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> (Recovery of) provision for bad debts </link:label>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA_label_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Provision for Doubtful Accounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA" xlink:to="lab_us-gaap_ProvisionForDoubtfulAccounts_AC815C3D0FFF94964EF0DE134A3692DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Provision for inventory obsolescence </link:label>
<link:label id="lab_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B_label_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Write-down </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryWriteDown" xlink:label="loc_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B" xlink:to="lab_us-gaap_InventoryWriteDown_22D2F19C63794474CC15DE134A360B7B" xlink:type="arc"/>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68_negatedLabel_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Revenue from receipt of equity </link:label>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68_label_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Receipt of Equity </link:label>
<link:label id="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68_documentation_en-US" xlink:label="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue from receipt of equity. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_RevenueFromReceiptOfEquity" xlink:label="loc_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:to="lab_opk_RevenueFromReceiptOfEquity_99FF4013CA0DD5DF7B92DE134A36BB68" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_8C11496EB9F6D64694D8DE134A36DE22_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_8C11496EB9F6D64694D8DE134A36DE22" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Realized gain on sale of equity securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_8C11496EB9F6D64694D8DE134A36DE22" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSaleOfInvestments_8C11496EB9F6D64694D8DE134A36DE22" xlink:to="lab_us-gaap_GainLossOnSaleOfInvestments_8C11496EB9F6D64694D8DE134A36DE22" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_806F482B022A390326FADE134A364A6E_negatedLabel_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_806F482B022A390326FADE134A364A6E" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> (Gain) loss on conversion of 3.00% convertible senior notes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_806F482B022A390326FADE134A364A6E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_806F482B022A390326FADE134A364A6E" xlink:to="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_806F482B022A390326FADE134A364A6E" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6C2C9AB9609AEEE752C8DE134A36DF07_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6C2C9AB9609AEEE752C8DE134A36DF07" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of derivative instruments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6C2C9AB9609AEEE752C8DE134A36DF07" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6C2C9AB9609AEEE752C8DE134A36DF07" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6C2C9AB9609AEEE752C8DE134A36DF07" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_5707BD7C711258A2A23DDE134A368718_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_5707BD7C711258A2A23DDE134A368718" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_5707BD7C711258A2A23DDE134A368718" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_5707BD7C711258A2A23DDE134A368718" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_5707BD7C711258A2A23DDE134A368718" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeconsolidationGainOrLossAmount_518390C73B4DC5BFD39EDE134A36FD6F_negatedLabel_en-US" xlink:label="lab_us-gaap_DeconsolidationGainOrLossAmount_518390C73B4DC5BFD39EDE134A36FD6F" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Gain on deconsolidation of SciVac </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeconsolidationGainOrLossAmount" xlink:label="loc_us-gaap_DeconsolidationGainOrLossAmount_518390C73B4DC5BFD39EDE134A36FD6F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeconsolidationGainOrLossAmount_518390C73B4DC5BFD39EDE134A36FD6F" xlink:to="lab_us-gaap_DeconsolidationGainOrLossAmount_518390C73B4DC5BFD39EDE134A36FD6F" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred income tax (benefit) expense </link:label>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1" xlink:to="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_B536F81874B3A3462C15DE134A3612E1" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in assets and liabilities, net of the effects of acquisitions: </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Operating Capital [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF" xlink:to="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_063BB7B9D811D7390064DE134A3656FF" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_14E5C20E745DC4E2E8A3DE134A3684AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Inventory </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Inventories </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED" xlink:to="lab_us-gaap_IncreaseDecreaseInInventories_59ADF701CD19072031D3DE134A3671ED" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Prepaid Expense and Other Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2" xlink:to="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_9DE9016DB00F55883B71DE134A3669A2" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Other Operating Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867" xlink:to="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_AA4A92011AB09DD38683DE134A363867" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsPayable_4A94551BA07D702FEF2DDE134A36AC77" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA_negatedLabel_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency measurement </link:label>
<link:label id="lab_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA_label_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Currency Transaction Gain (Loss), before Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA" xlink:to="lab_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9DC9F96FC34450DF3AD1DE134A36C5AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C" xlink:to="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_CEF03943B1D04643D720DE134A36A61C" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses and other liabilities </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accrued Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025" xlink:to="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_3E97FDBCB74783F8BDB4DE134A37E025" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by (used in) operating activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_4577D3FB4574670DAF0BDE134A37567D" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from investing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_B5359FFC7B3BE0753B40DE134A37BA41" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Investments in investees </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081" xlink:to="lab_us-gaap_PaymentsToAcquireInvestments_F04421A77C0D7404EF97DE134A37E081" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from sale of equity securities </link:label>
<link:label id="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00_label_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for (Proceeds from) Other Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00" xlink:to="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_21B2EBD14957491093D5DE134A371A00" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Acquisition of businesses, net of cash </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Businesses, Net of Cash Acquired </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_510EC756F1AE9A71FCDBDE134A3733A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisition of intangible assets </link:label>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Sale of Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E" xlink:to="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_B4ACD561E39F2D5A91A1DE17F8302E5E" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Capital expenditures </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Productive Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B" xlink:to="lab_us-gaap_PaymentsToAcquireProductiveAssets_E38537B5B0F4672CC70DDE134A376B6B" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash used in investing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_BB6E7F321B8105B70F02DE134A37878B" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from financing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_E0C28C3ACBAD89631E9EDE134A3714A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Issuance of 2033 Senior Notes, net, including related parties </link:label>
<link:label id="lab_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E_label_en-US" xlink:label="lab_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Convertible Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E" xlink:to="lab_us-gaap_ProceedsFromConvertibleDebt_076594453A65CE8F8C08DE134A37D83E" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from the exercise of Common Stock options and warrants </link:label>
<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Issuance or Sale of Equity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3" xlink:to="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_1EC394BD325FF2B842B9DE134A37DCB3" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash from non-controlling interest </link:label>
<link:label id="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8_label_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from (Payments to) Noncontrolling Interests </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromPaymentsToMinorityShareholders" xlink:label="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8" xlink:to="lab_us-gaap_ProceedsFromPaymentsToMinorityShareholders_A12BDA149F6163ACF6CADE134A379DD8" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration payments </link:label>
<link:label id="lab_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53_label_en-US" xlink:label="lab_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for Previous Acquisition </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForPreviousAcquisition" xlink:label="loc_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53" xlink:to="lab_us-gaap_PaymentsForPreviousAcquisition_90B34E3FCB98273B9B9FDE134A376B53" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Borrowings on lines of credit </link:label>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753" xlink:to="lab_us-gaap_ProceedsFromLinesOfCredit_DDA4E1FFFCD5A5A03D7FDE134A37B753" xlink:type="arc"/>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Repayments of lines of credit </link:label>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Repayments of Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68" xlink:to="lab_us-gaap_RepaymentsOfLinesOfCredit_CFDBA4F45B3EAF67A244DE134A374B68" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by financing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_00D78EB193D571527478DE134A37EB06" xlink:type="arc"/>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC_verboseLabel_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Effect of exchange rate on cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC_label_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effect of Exchange Rate on Cash and Cash Equivalents </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC" xlink:to="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_EE12609A358647B55173DE134A3734DC" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C_totalLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net increase (decrease) in cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Period Increase (Decrease) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C" xlink:to="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_97E735E498C6F62A45B5DE134A37B42C" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_621DAA3BBAF4975A87F5DE134A37C6D9_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_621DAA3BBAF4975A87F5DE134A37C6D9" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at beginning of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_621DAA3BBAF4975A87F5DE134A37C6D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_621DAA3BBAF4975A87F5DE134A37C6D9" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_621DAA3BBAF4975A87F5DE134A37C6D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_D364D620562CEC50D463DE134A377FBE_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_D364D620562CEC50D463DE134A377FBE" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at end of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_D364D620562CEC50D463DE134A377FBE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_D364D620562CEC50D463DE134A377FBE" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_D364D620562CEC50D463DE134A377FBE" xlink:type="arc"/>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUPPLEMENTAL INFORMATION: </link:label>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D_label_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Cash Flow Information [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D" xlink:to="lab_us-gaap_SupplementalCashFlowInformationAbstract_495281EA9A2D92371189DE134A38EB4D" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes paid, net </link:label>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Taxes Paid, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65" xlink:to="lab_us-gaap_IncomeTaxesPaidNet_304FD361B34CFFFCB56EDE134A380E65" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62_terseLabel_en-US" xlink:label="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez common stock received </link:label>
<link:label id="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62_label_en-US" xlink:label="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Significant Noncash Transaction, Value of Consideration Received </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62" xlink:to="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_9A1BBDD836B6FB2D514CDE134A380F62" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A_verboseLabel_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash financing: </link:label>
<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A_label_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A" xlink:to="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_47AFA2982B4244BF5112DE134A38D98A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86_terseLabel_en-US" xlink:label="lab_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86_label_en-US" xlink:label="lab_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Conversion of Stock, Amount Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConversionOfStockAmountIssued1" xlink:label="loc_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86" xlink:to="lab_us-gaap_ConversionOfStockAmountIssued1_3F3111BD812A29F793CEDE134A386A86" xlink:type="arc"/>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F_verboseLabel_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock options and warrants, surrendered in net exercise </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F_label_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock Warrants Net Exercised </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F_documentation_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Common stock warrants net exercised. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_CommonStockWarrantsNetExercised" xlink:label="loc_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:to="lab_opk_CommonStockWarrantsNetExercised_CE487EC7C04A171475CEDE134A38166F" xlink:type="arc"/>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Issuance of Common Stock to acquire: </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" xlink:label="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:to="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_22EC66EFCBF04A5B66FEDE134A38209A" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital stock to acquire </link:label>
<link:label id="lab_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE_label_en-US" xlink:label="lab_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE" xlink:to="lab_us-gaap_StockIssued1_A05A74FF34168EA7A272DE134A38B5FE" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of principal amounts, unamortized discount and net carrying amounts </link:label>
<link:label id="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6" xlink:to="lab_us-gaap_ScheduleOfDebtInstrumentsTextBlock_9CF4018F2738E95A2574873B289AAEB6" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inputs to lattice model used to value the embedded derivative </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_C85CAFDB09A0D48D2F11873B289A8340" xlink:type="arc"/>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11_verboseLabel_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of notes with and without the embedded derivatives and fair value of embedded derivatives </link:label>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11_label_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value of Notes With and Without Embedded Derivatives And Fair Value Of Embedded Derivatives [Table Text Block] </link:label>
<link:label id="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11_documentation_en-US" xlink:label="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair value of notes with and without embedded derivatives and fair value of embedded derivatives. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" xlink:label="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:to="lab_opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock_647CD0366D0384BDD609873B289A5C11" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of lines of credit </link:label>
<link:label id="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Line of Credit Facilities [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock" xlink:label="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0" xlink:to="lab_us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_2CF58B3643FFE6F94A69873B289A8EE0" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_7237F96DF601DBBC4B0DECDF918B696F_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_7237F96DF601DBBC4B0DECDF918B696F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current assets: </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_7237F96DF601DBBC4B0DECDF918B696F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrentAbstract_7237F96DF601DBBC4B0DECDF918B696F" xlink:to="lab_us-gaap_AssetsCurrentAbstract_7237F96DF601DBBC4B0DECDF918B696F" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_0579FFC18DD3C31F89EDECDF918B8206_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_0579FFC18DD3C31F89EDECDF918B8206" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_0579FFC18DD3C31F89EDECDF918B8206" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_0579FFC18DD3C31F89EDECDF918B8206" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentNet_0579FFC18DD3C31F89EDECDF918B8206" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD" xlink:to="lab_us-gaap_LiabilitiesAbstract_D6C62C51A08BA3D67590ECDF918CCCFD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_329B674659C8470F116DECDF918C56B2_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_329B674659C8470F116DECDF918C56B2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current liabilities: </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_329B674659C8470F116DECDF918C56B2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_329B674659C8470F116DECDF918C56B2" xlink:to="lab_us-gaap_LiabilitiesCurrentAbstract_329B674659C8470F116DECDF918C56B2" xlink:type="arc"/>
<link:label id="lab_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A_verboseLabel_en-US" xlink:label="lab_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Notes payable </link:label>
<link:label id="lab_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A_label_en-US" xlink:label="lab_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Payable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NotesPayableCurrent" xlink:label="loc_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A" xlink:to="lab_us-gaap_NotesPayableCurrent_C0B017435B719CB664D1ECDF918C5C8A" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1" xlink:to="lab_us-gaap_LineOfCreditFacilityTable_BA685DA3EE565A88DA90A50A0754A2A1" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D" xlink:to="lab_us-gaap_LineOfCreditFacilityAxis_5D9BBF83FE5F23D69200A50A07549D1D" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002" xlink:to="lab_us-gaap_LineOfCreditFacilityLenderDomain_A900AAE1F83247AFC825A50A07544002" xlink:type="arc"/>
<link:label id="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125_terseLabel_en-US" xlink:label="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> PNC Bank </link:label>
<link:label id="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125_label_en-US" xlink:label="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> PNC Bank [Member] </link:label>
<link:label id="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125_documentation_en-US" xlink:label="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> PNC Bank [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PNCBankMember" xlink:label="loc_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:to="lab_opk_PNCBankMember_877B1091E32633B40CA7A51C1327B125" xlink:type="arc"/>
<link:label id="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2_verboseLabel_en-US" xlink:label="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Itau Bank </link:label>
<link:label id="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2_label_en-US" xlink:label="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Itau Bank [Member] </link:label>
<link:label id="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2_documentation_en-US" xlink:label="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Itau. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ItauBankMember" xlink:label="loc_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:to="lab_opk_ItauBankMember_2BA02D7D35964B31D638A50A075494E2" xlink:type="arc"/>
<link:label id="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016_verboseLabel_en-US" xlink:label="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Bank of Chile </link:label>
<link:label id="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016_label_en-US" xlink:label="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bank of Chile [Member] </link:label>
<link:label id="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016_documentation_en-US" xlink:label="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bank of Chile. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BankOfChileMember" xlink:label="loc_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:to="lab_opk_BankOfChileMember_7E3DCC6DC3FB116A3F38A50A0754D016" xlink:type="arc"/>
<link:label id="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2_verboseLabel_en-US" xlink:label="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BICE Bank </link:label>
<link:label id="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2_label_en-US" xlink:label="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bice Bank [Member] </link:label>
<link:label id="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2_documentation_en-US" xlink:label="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BICE Bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BiceBankMember" xlink:label="loc_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:to="lab_opk_BiceBankMember_1A2AC541C031A83F5457A50A07541DA2" xlink:type="arc"/>
<link:label id="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B_verboseLabel_en-US" xlink:label="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BBVA Bank </link:label>
<link:label id="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B_label_en-US" xlink:label="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> BBVA Bank [Member] </link:label>
<link:label id="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B_documentation_en-US" xlink:label="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BBVA bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BbvaBankMember" xlink:label="loc_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:to="lab_opk_BbvaBankMember_E1995A469DA0188B5EC1A50A07547A9B" xlink:type="arc"/>
<link:label id="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0_verboseLabel_en-US" xlink:label="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Penta Bank </link:label>
<link:label id="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0_label_en-US" xlink:label="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Penta Bank [Member] </link:label>
<link:label id="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0_documentation_en-US" xlink:label="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Penta bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_PentaBankMember" xlink:label="loc_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:to="lab_opk_PentaBankMember_29D56129CD69F92A2735A50A075491C0" xlink:type="arc"/>
<link:label id="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD_verboseLabel_en-US" xlink:label="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Security Bank </link:label>
<link:label id="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD_label_en-US" xlink:label="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Security [Member] </link:label>
<link:label id="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD_documentation_en-US" xlink:label="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Security. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SecurityMember" xlink:label="loc_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:to="lab_opk_SecurityMember_26771EA80E1DA5DE81A5A50A07548AAD" xlink:type="arc"/>
<link:label id="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB_verboseLabel_en-US" xlink:label="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estado Bank </link:label>
<link:label id="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB_label_en-US" xlink:label="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Estado Bank [Member] </link:label>
<link:label id="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB_documentation_en-US" xlink:label="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estado bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_EstadoBankMember" xlink:label="loc_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:to="lab_opk_EstadoBankMember_494E6B680CF4BBEE0B75A50A075415DB" xlink:type="arc"/>
<link:label id="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC_verboseLabel_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BBVA Bank </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC_label_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bilbao Vizcaya Bank [Member] </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC_documentation_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bilbao vizcaya bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_BilbaoVizcayaBankMember" xlink:label="loc_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:to="lab_opk_BilbaoVizcayaBankMember_F841BEB94101506E9A50A50A075450AC" xlink:type="arc"/>
<link:label id="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5_terseLabel_en-US" xlink:label="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Santander Bank </link:label>
<link:label id="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5_label_en-US" xlink:label="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Santander Bank [Member] </link:label>
<link:label id="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5_documentation_en-US" xlink:label="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> santander Bank. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_SantanderBankMember" xlink:label="loc_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:to="lab_opk_SantanderBankMember_BDC5566BCF6F2BEF69DAA51BACF13AB5" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0" xlink:to="lab_us-gaap_LineOfCreditFacilityLineItems_BB8F3D9B6477B8245C3DA50A07544BB0" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_532AD7FD75543F0EAB02A50A0754EF67_verboseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_532AD7FD75543F0EAB02A50A0754EF67" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on borrowings at September 30, 2015 </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_532AD7FD75543F0EAB02A50A0754EF67" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_532AD7FD75543F0EAB02A50A0754EF67" xlink:to="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_532AD7FD75543F0EAB02A50A0754EF67" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Outstanding </link:label>
<link:label id="lab_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71_label_en-US" xlink:label="lab_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71" xlink:to="lab_us-gaap_LineOfCredit_C98EC966A5C51DC51B5BA50A0754CF71" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfGoodwillTable" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25" xlink:to="lab_us-gaap_ScheduleOfGoodwillTable_9AA1A98768A8244F640ED973C2AEBD25" xlink:type="arc"/>
<link:label id="lab_opk_FineTechMember_B6F83F3BBA3070840BA9D973C2AF2A9F_terseLabel_en-US" xlink:label="lab_opk_FineTechMember_B6F83F3BBA3070840BA9D973C2AF2A9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> FineTech </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_B6F83F3BBA3070840BA9D973C2AF2A9F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FineTechMember_B6F83F3BBA3070840BA9D973C2AF2A9F" xlink:to="lab_opk_FineTechMember_B6F83F3BBA3070840BA9D973C2AF2A9F" xlink:type="arc"/>
<link:label id="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5_terseLabel_en-US" xlink:label="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5_label_en-US" xlink:label="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Chile [Member] </link:label>
<link:label id="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5_documentation_en-US" xlink:label="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Opko Chile. </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OpkoChileMember" xlink:label="loc_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:to="lab_opk_OpkoChileMember_52309257187F8AEBD522D973C2AFF1A5" xlink:type="arc"/>
<link:label id="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A_terseLabel_en-US" xlink:label="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Mexico </link:label>
<link:label id="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A_label_en-US" xlink:label="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Mexico [Member] </link:label>
<link:label id="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A_documentation_en-US" xlink:label="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Mexico [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OPKOMexicoMember" xlink:label="loc_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:to="lab_opk_OPKOMexicoMember_3C0E601A6E2A98641BC6D973C2AF078A" xlink:type="arc"/>
<link:label id="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4_terseLabel_en-US" xlink:label="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics </link:label>
<link:label id="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4_label_en-US" xlink:label="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:label id="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4_documentation_en-US" xlink:label="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_ClarosMember" xlink:label="loc_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:to="lab_opk_ClarosMember_8A46BF147331547B3234D973C2AFF4F4" xlink:type="arc"/>
<link:label id="lab_opk_OpkoDiagnosticsMember_A938B817449DA2F81928D973C2AF7C50_verboseLabel_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_A938B817449DA2F81928D973C2AF7C50" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Lab </link:label>
<link:loc xlink:href="opk-20150930.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_A938B817449DA2F81928D973C2AF7C50" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoDiagnosticsMember_A938B817449DA2F81928D973C2AF7C50" xlink:to="lab_opk_OpkoDiagnosticsMember_A938B817449DA2F81928D973C2AF7C50" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:label id="lab_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408_label_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillLineItems" xlink:label="loc_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408" xlink:to="lab_us-gaap_GoodwillLineItems_31D2329B118536388CAED973C2AF6408" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:label id="lab_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7_label_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillRollForward" xlink:label="loc_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7" xlink:to="lab_us-gaap_GoodwillRollForward_102CCA246C4F594FDD39D973C2AFC0A7" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_357A535B6B94BA7B9C3CD973C2AF016A_periodStartLabel_en-US" xlink:label="lab_us-gaap_Goodwill_357A535B6B94BA7B9C3CD973C2AF016A" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_357A535B6B94BA7B9C3CD973C2AF016A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_357A535B6B94BA7B9C3CD973C2AF016A" xlink:to="lab_us-gaap_Goodwill_357A535B6B94BA7B9C3CD973C2AF016A" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisitions and deconsolidation </link:label>
<link:label id="lab_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720_label_en-US" xlink:label="lab_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Acquired During Period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAcquiredDuringPeriod" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720" xlink:to="lab_us-gaap_GoodwillAcquiredDuringPeriod_48793147D036CCBF311CD973C2B04720" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Foreign exchange </link:label>
<link:label id="lab_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9_label_en-US" xlink:label="lab_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Other Changes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillOtherChanges" xlink:label="loc_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9" xlink:to="lab_us-gaap_GoodwillOtherChanges_CBBA051F31AEBDFDA641D973C2B0FBD9" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_1D2E80579BE5499598A7D973C2B047BE_periodEndLabel_en-US" xlink:label="lab_us-gaap_Goodwill_1D2E80579BE5499598A7D973C2B047BE" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_1D2E80579BE5499598A7D973C2B047BE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_1D2E80579BE5499598A7D973C2B047BE" xlink:to="lab_us-gaap_Goodwill_1D2E80579BE5499598A7D973C2B047BE" xlink:type="arc"/>
</link:labelLink>
</link:linkbase>

↑Top
Filing Submission 0000944809-15-000014   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Sun., Apr. 28, 3:48:12.2pm ET