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| | | <link:roleType id="SegmentsOperationsAndAssetsInformationDetails" roleURI="http://www.opko.com/role/SegmentsOperationsAndAssetsInformationDetails"> |
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| | | <link:roleType id="SegmentsTables" roleURI="http://www.opko.com/role/SegmentsTables"> |
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| | | <link:roleType id="StrategicAlliances" roleURI="http://www.opko.com/role/StrategicAlliances"> |
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| | | <link:roleType id="SummaryOfSignificantAccountingPolicies" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPolicies"> |
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| | | <link:roleType id="SummaryOfSignificantAccountingPoliciesDetails" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesDetails"> |
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| | | <link:roleType id="SummaryOfSignificantAccountingPoliciesPolicies" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies"> |
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| | | </xsd:appinfo> |
| | </xsd:annotation> |
| <xsd:element abstract="true" id="opk_ARNOMember" name="ARNOMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember" name="AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_AccruedClinicalTrialsCurrent" name="AccruedClinicalTrialsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_AllowanceForDoubtfulAccountsPolicyTextBlock" name="AllowanceForDoubtfulAccountsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_AutomobilesandAircraftMember" name="AutomobilesandAircraftMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_AvailableforSaleSecuritiesOwnershipPercentage" name="AvailableforSaleSecuritiesOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/> |
| <xsd:element id="opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod" name="AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BankOfChileMember" name="BankOfChileMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BbvaBankMember" name="BbvaBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BiceBankMember" name="BiceBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BilbaoVizcayaBankMember" name="BilbaoVizcayaBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BioCardiaInc.Member" name="BioCardiaInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_BioReferenceMember" name="BioReferenceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" name="BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" name="BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_CURNAMember" name="CURNAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ChromaDexMember" name="ChromaDexMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ClarosMember" name="ClarosMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CocrystalMember" name="CocrystalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeAgreementAdditionalMilestonePayment" name="CollaborativeAgreementAdditionalMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeAgreementPeriodfromFirstCommercialSale" name="CollaborativeAgreementPeriodfromFirstCommercialSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangement.MaximumMilestonePayments" name="CollaborativeArrangement.MaximumMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementMilestonePayment" name="CollaborativeArrangementMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementMilestonePaymentReceived" name="CollaborativeArrangementMilestonePaymentReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementUpfrontPayment" name="CollaborativeArrangementUpfrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" name="CompositionOfCertainFinancialStatementCaptionsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" name="CompositionsOfCertainFinancialStatementCaptionsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ContingentConsiderationMember" name="ContingentConsiderationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" name="ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_Corpbanca1Member" name="Corpbanca1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CostMethodInvestmentOwnershipPercentage" name="CostMethodInvestmentOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CostMethodInvestmentSharesPurchasedinPeriod" name="CostMethodInvestmentSharesPurchasedinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_Customer1Member" name="Customer1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentConvertibleConversionRightTriggered" name="DebtInstrumentConvertibleConversionRightTriggered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DebtInstrumentRollForward" name="DebtInstrumentRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentsNumberofFinancialInstitutions" name="DebtInstrumentsNumberofFinancialInstitutions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_DevelopmentandLicenseAgreementMember" name="DevelopmentandLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DiagnosticsMember" name="DiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DrFrostMember" name="DrFrostMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DrFrostandMrPfennigerMember" name="DrFrostandMrPfennigerMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EirGenPharmaLimitedMember" name="EirGenPharmaLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" name="EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EloxxPharmaceuticalsMember" name="EloxxPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" name="EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquityMethodInvestmentExcludingVariableInterestEntity" name="EquityMethodInvestmentExcludingVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquityMethodInvestmentSharesPurchasedInPeriod" name="EquityMethodInvestmentSharesPurchasedInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EquityMethodInvestmentVariableInterestEntity" name="EquityMethodInvestmentVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_EstadoBankMember" name="EstadoBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ExclusiveOptionMember" name="ExclusiveOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" name="FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" name="FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" name="FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FineTechMember" name="FineTechMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FrostRealEstateHoldingsLLCMember" name="FrostRealEstateHoldingsLLCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_InCellDxIncMember" name="InCellDxIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" name="IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncreaseDecreaseinForeignCurrencyMeasurement" name="IncreaseDecreaseinForeignCurrencyMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_InterestExpenseNonoperating" name="InterestExpenseNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_InterestIncomeNonoperating" name="InterestIncomeNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ItauBankMember" name="ItauBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_JPMorganChaseMember" name="JPMorganChaseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LaunchandSalesbasedMilestonesMember" name="LaunchandSalesbasedMilestonesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment" name="LicenseandCollaborationAgreementsProceedsasUpFrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LineofCreditAgreementIntercompanyLoanMaximum" name="LineofCreditAgreementIntercompanyLoanMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" name="LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" name="LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" name="LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" name="LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORThereafterMember" name="LondonInterbankOfferedRateLIBORThereafterMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MabVaxTherapeuticsHoldingsInc.Member" name="MabVaxTherapeuticsHoldingsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MuseumofScienceIncMember" name="MuseumofScienceIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NIMSMember" name="NIMSMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NeovascMember" name="NeovascMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NewCreditAgreementMember" name="NewCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NonInvasiveMonitoringSystemsInc.Member" name="NonInvasiveMonitoringSystemsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NotesDueFebruary12033Member" name="NotesDueFebruary12033Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_NumberofSalesEmployees" name="NumberofSalesEmployees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OPKOBiologicsMember" name="OPKOBiologicsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OPKOHealthEuropeMember" name="OPKOHealthEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OPKORentalMember" name="OPKORentalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearOne" name="OperatingLeasesMonthlyPaymentsYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearThree" name="OperatingLeasesMonthlyPaymentsYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_OpkoChileMember" name="OpkoChileMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OpkoDiagnosticsMember" name="OpkoDiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_PercentageOfIncreaseDecreaseInFutureSales" name="PercentageOfIncreaseDecreaseInFutureSales" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_PfizerMember" name="PfizerMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PharmaceuticalMember" name="PharmaceuticalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PharmsynthezMember" name="PharmsynthezMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PharmsynthezNoteReceivableMember" name="PharmsynthezNoteReceivableMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember" name="PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ProductRegistrationsMember" name="ProductRegistrationsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_RayaldeeMember" name="RayaldeeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_RegulatoryMilestonesMember" name="RegulatoryMilestonesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ReimbursementOfTravelExpenseMember" name="ReimbursementOfTravelExpenseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_RelatedPartyTransactionFutureContributions" name="RelatedPartyTransactionFutureContributions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_RelativeCoreMember" name="RelativeCoreMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_RevenueFromTransferOfIntellectualProperty" name="RevenueFromTransferOfIntellectualProperty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_RoyaltyRevenueObligationPeriod" name="RoyaltyRevenueObligationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_RxiMember" name="RxiMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_RxiPharmaceuticalsCorporationMember" name="RxiPharmaceuticalsCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SantanderBank2MemberMember" name="SantanderBank2MemberMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SantanderBankMember" name="SantanderBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ScotiabankMember" name="ScotiabankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SeriesIPreferredStockMember" name="SeriesIPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SevionMember" name="SevionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract" name="SharesIssuedintheConversionofStockandDebtInstrumentsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_SharesReceivedAsGift" name="SharesReceivedAsGift" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_SharesSurrenderedInLieuOfCashPayment" name="SharesSurrenderedInLieuOfCashPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" name="StockIssuedDuringPeriodSharesAcquisitionAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" name="StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" name="StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockOptionandWarrantInvestments" name="StockOptionandWarrantInvestments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_StrategicAlliancesTextBlock" name="StrategicAlliancesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_TaxesRecoverableCurrent" name="TaxesRecoverableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_TesaroMember" name="TesaroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" name="ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TransitionTherapeuticsInc.Member" name="TransitionTherapeuticsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_VBIVaccinesIncMember" name="VBIVaccinesIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ViforFreseniusMedicalCarePharmaLtdMember" name="ViforFreseniusMedicalCarePharmaLtdMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_XeneticBiosciencesInc.Member" name="XeneticBiosciencesInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ZebraMember" name="ZebraMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/> |
| </xsd:schema> |