SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-Q’ for 6/30/17 – ‘EX-101.SCH’

On:  Tuesday, 8/8/17, at 4:15pm ET   ·   For:  6/30/17   ·   Accession #:  944809-17-8   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 5/10/17 for 3/31/17   ·   Next:  ‘10-Q’ on 11/8/17 for 9/30/17   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 8/08/17  Opko Health, Inc.                 10-Q        6/30/17   75:8.9M

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    648K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     22K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     22K 
12: R1          Document and Entity Information                     HTML     40K 
13: R2          Condensed Consolidated Balance Sheets               HTML    100K 
14: R3          Condensed Consolidated Balance Sheets               HTML     30K 
                (Parenthetical)                                                  
15: R4          Condensed Consolidated Statements of Operations     HTML     94K 
16: R5          Condensed Consolidated Statements of Comprehensive  HTML     41K 
                Income (Loss)                                                    
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    124K 
18: R7          Business and Organization                           HTML     28K 
19: R8          Summary of Significant Accounting Policies          HTML     77K 
20: R9          Earnings (Loss) Per Share                           HTML     78K 
21: R10         Composition of Certain Financial Statement          HTML    122K 
                Captions                                                         
22: R11         Acquisitions, Investments and Licenses              HTML     60K 
23: R12         Debt                                                HTML    125K 
24: R13         Accumulated Other Comprehensive Income (Loss)       HTML     38K 
25: R14         Fair Value Measurements                             HTML    140K 
26: R15         Derivative Contracts                                HTML     54K 
27: R16         Related Party Transactions                          HTML     35K 
28: R17         Commitments and Contingencies                       HTML     32K 
29: R18         Strategic Alliances                                 HTML     50K 
30: R19         Segments                                            HTML    153K 
31: R20         Subsequent Events                                   HTML     23K 
32: R21         Summary of Significant Accounting Policies          HTML    136K 
                (Policies)                                                       
33: R22         Earnings (Loss) Per Share (Tables)                  HTML     72K 
34: R23         Composition of Certain Financial Statement          HTML    123K 
                Captions (Tables)                                                
35: R24         Acquisitions, Investments and Licenses (Tables)     HTML     48K 
36: R25         Debt (Tables)                                       HTML    110K 
37: R26         Accumulated Other Comprehensive Income (Loss)       HTML     38K 
                (Tables)                                                         
38: R27         Fair Value Measurements (Tables)                    HTML    141K 
39: R28         Derivative Contracts (Tables)                       HTML     55K 
40: R29         Segments (Tables)                                   HTML    151K 
41: R30         Business and Organization (Details)                 HTML     34K 
42: R31         Summary of Significant Accounting Policies          HTML    130K 
                (Details)                                                        
43: R32         Earnings (Loss) Per Share - Schedule of Earnings    HTML     59K 
                Per Share (Details)                                              
44: R33         Earnings (Loss) Per Share - Narrative (Details)     HTML     33K 
45: R34         Composition of Certain Financial Statement          HTML    138K 
                Captions (Details)                                               
46: R35         Composition of Certain Financial Statement          HTML     57K 
                Captions - Changes in Goodwill (Details)                         
47: R36         Acquisitions, Investments and Licenses -            HTML     32K 
                Acquisition Narrative (Details)                                  
48: R37         Acquisitions, Investments and Licenses -            HTML     44K 
                Transition Therapeutics Purchase Price Allocation                
                (Details)                                                        
49: R38         Acquisitions, Investments and Licenses - Summary    HTML     37K 
                of Investments (Details)                                         
50: R39         Acquisitions, Investments and Licenses - Equity     HTML     57K 
                and Cost Method Investments Narrative (Details)                  
51: R40         Acquisitions, Investments and Licenses - Available  HTML     51K 
                for Sale Investments, Sale of Investments and                    
                Warrants and Options Narrative (Details)                         
52: R41         Acquisitions, Investments and Licenses - Variable   HTML     33K 
                Interest Entities Narrative (Details)                            
53: R42         Acquisitions, Investments and Licenses - Other      HTML     40K 
                Narrative (Details)                                              
54: R43         Debt - Narrative (Details)                          HTML    143K 
55: R44         Debt - Notes (Details)                              HTML     51K 
56: R45         Debt - Inputs Used In Lattice Model (Details)       HTML     40K 
57: R46         Debt - Fair Value Of Embedded Derivatives           HTML     28K 
                (Details)                                                        
58: R47         Debt - Lines Of Credit (Details)                    HTML     60K 
59: R48         Debt - Mortgage Notes And Other Debt (Details)      HTML     31K 
60: R49         Accumulated Other Comprehensive Income (Loss)       HTML     43K 
                (Details)                                                        
61: R50         Fair Value Measurements - Summary Of Investments    HTML     35K 
                (Details)                                                        
62: R51         Fair Value Measurements - Assets And Liabilities    HTML     54K 
                Measured At Fair Value (Details)                                 
63: R52         Fair Value Measurements - Notes (Details)           HTML     29K 
64: R53         Fair Value Measurements - Level 3 Reconciliation    HTML     36K 
                (Details)                                                        
65: R54         Fair Value Measurements - Narrative (Details)       HTML     33K 
66: R55         Derivative Contracts - Balance Sheet Component      HTML     39K 
                (Details)                                                        
67: R56         Derivative Contracts - Derivative Gains (Losses)    HTML     32K 
                (Details)                                                        
68: R57         Related Party Transactions (Details)                HTML    164K 
69: R58         Commitments and Contingencies (Details)             HTML     36K 
70: R59         Strategic Alliances (Details)                       HTML    104K 
71: R60         Segments - Narrative (Details)                      HTML     41K 
72: R61         Segments - Operations and Assets Information        HTML     78K 
                (Details)                                                        
74: XML         IDEA XML File -- Filing Summary                      XML    132K 
73: EXCEL       IDEA Workbook of Financial Reports                  XLSX    106K 
 6: EX-101.INS  XBRL Instance -- opk-20170630                        XML   2.77M 
 8: EX-101.CAL  XBRL Calculations -- opk-20170630_cal                XML    251K 
 9: EX-101.DEF  XBRL Definitions -- opk-20170630_def                 XML    971K 
10: EX-101.LAB  XBRL Labels -- opk-20170630_lab                      XML   1.93M 
11: EX-101.PRE  XBRL Presentations -- opk-20170630_pre               XML   1.20M 
 7: EX-101.SCH  XBRL Schema -- opk-20170630                          XSD    180K 
75: ZIP         XBRL Zipped Folder -- 0000944809-17-000008-xbrl      Zip    290K 


‘EX-101.SCH’   —   XBRL Schema — opk-20170630


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- -->
<xsd:schema attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.opko.com/20170630" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:opk="http://www.opko.com/20170630" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsd="http://www.w3.org/2001/XMLSchema">
<xsd:import namespace="http://fasb.org/us-gaap/2017-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd"/>
<xsd:import namespace="http://fasb.org/us-roles/2017-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2017/elts/us-roles-2017-01-31.xsd"/>
<xsd:import namespace="http://fasb.org/us-types/2017-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2017/elts/us-types-2017-01-31.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/currency/2017-01-31" schemaLocation="http://xbrl.sec.gov/currency/2017/currency-2017-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/exch/2017-01-31" schemaLocation="http://xbrl.sec.gov/exch/2017/exch-2017-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
<xsd:import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<xsd:annotation>
<xsd:appinfo>
<link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="opk-20170630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
<link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="opk-20170630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
<link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="opk-20170630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
<link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="opk-20170630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
<link:roleType id="AccumulatedOtherComprehensiveIncomeLoss" roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLoss">
<link:definition> 2107100 - Disclosure - Accumulated Other Comprehensive Income (Loss) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AccumulatedOtherComprehensiveIncomeLossDetails" roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossDetails">
<link:definition> 2407402 - Disclosure - Accumulated Other Comprehensive Income (Loss) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AccumulatedOtherComprehensiveIncomeLossTables" roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossTables">
<link:definition> 2307301 - Disclosure - Accumulated Other Comprehensive Income (Loss) (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicenses" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicenses">
<link:definition> 2105100 - Disclosure - Acquisitions, Investments and Licenses </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesAcquisitionNarrativeDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesAcquisitionNarrativeDetails">
<link:definition> 2405402 - Disclosure - Acquisitions, Investments and Licenses - Acquisition Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesAvailableForSaleInvestmentsSaleOfInvestmentsAndWarrantsAndOptionsNarrativeDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesAvailableForSaleInvestmentsSaleOfInvestmentsAndWarrantsAndOptionsNarrativeDetails">
<link:definition> 2405406 - Disclosure - Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesEquityAndCostMethodInvestmentsNarrativeDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesEquityAndCostMethodInvestmentsNarrativeDetails">
<link:definition> 2405405 - Disclosure - Acquisitions, Investments and Licenses - Equity and Cost Method Investments Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesOtherNarrativeDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesOtherNarrativeDetails">
<link:definition> 2405408 - Disclosure - Acquisitions, Investments and Licenses - Other Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesSummaryOfInvestmentsDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesSummaryOfInvestmentsDetails">
<link:definition> 2405404 - Disclosure - Acquisitions, Investments and Licenses - Summary of Investments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesTables" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTables">
<link:definition> 2305301 - Disclosure - Acquisitions, Investments and Licenses (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesTransitionTherapeuticsPurchasePriceAllocationDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesTransitionTherapeuticsPurchasePriceAllocationDetails">
<link:definition> 2405403 - Disclosure - Acquisitions, Investments and Licenses - Transition Therapeutics Purchase Price Allocation (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="AcquisitionsInvestmentsAndLicensesVariableInterestEntitiesNarrativeDetails" roleURI="http://www.opko.com/role/AcquisitionsInvestmentsAndLicensesVariableInterestEntitiesNarrativeDetails">
<link:definition> 2405407 - Disclosure - Acquisitions, Investments and Licenses - Variable Interest Entities Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessAndOrganization" roleURI="http://www.opko.com/role/BusinessAndOrganization">
<link:definition> 2101100 - Disclosure - Business and Organization </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessAndOrganizationDetails" roleURI="http://www.opko.com/role/BusinessAndOrganizationDetails">
<link:definition> 2401401 - Disclosure - Business and Organization (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CommitmentsAndContingencies" roleURI="http://www.opko.com/role/CommitmentsAndContingencies">
<link:definition> 2111100 - Disclosure - Commitments and Contingencies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CommitmentsAndContingenciesDetails" roleURI="http://www.opko.com/role/CommitmentsAndContingenciesDetails">
<link:definition> 2411401 - Disclosure - Commitments and Contingencies (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CompositionOfCertainFinancialStatementCaptions" roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptions">
<link:definition> 2104100 - Disclosure - Composition of Certain Financial Statement Captions </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CompositionOfCertainFinancialStatementCaptionsChangesInGoodwillDetails" roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsChangesInGoodwillDetails">
<link:definition> 2404403 - Disclosure - Composition of Certain Financial Statement Captions - Changes in Goodwill (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CompositionOfCertainFinancialStatementCaptionsDetails" roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails">
<link:definition> 2404402 - Disclosure - Composition of Certain Financial Statement Captions (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CompositionOfCertainFinancialStatementCaptionsTables" roleURI="http://www.opko.com/role/CompositionOfCertainFinancialStatementCaptionsTables">
<link:definition> 2304301 - Disclosure - Composition of Certain Financial Statement Captions (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CondensedConsolidatedBalanceSheets" roleURI="http://www.opko.com/role/CondensedConsolidatedBalanceSheets">
<link:definition> 1001000 - Statement - Condensed Consolidated Balance Sheets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CondensedConsolidatedBalanceSheetsParenthetical" roleURI="http://www.opko.com/role/CondensedConsolidatedBalanceSheetsParenthetical">
<link:definition> 1001501 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CondensedConsolidatedStatementsOfCashFlows" roleURI="http://www.opko.com/role/CondensedConsolidatedStatementsOfCashFlows">
<link:definition> 1005000 - Statement - Condensed Consolidated Statements of Cash Flows </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CondensedConsolidatedStatementsOfComprehensiveIncomeLoss" roleURI="http://www.opko.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLoss">
<link:definition> 1003000 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CondensedConsolidatedStatementsOfOperations" roleURI="http://www.opko.com/role/CondensedConsolidatedStatementsOfOperations">
<link:definition> 1002000 - Statement - Condensed Consolidated Statements of Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="Debt" roleURI="http://www.opko.com/role/Debt">
<link:definition> 2106100 - Disclosure - Debt </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtFairValueOfEmbeddedDerivativesDetails" roleURI="http://www.opko.com/role/DebtFairValueOfEmbeddedDerivativesDetails">
<link:definition> 2406405 - Disclosure - Debt - Fair Value Of Embedded Derivatives (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtInputsUsedInLatticeModelDetails" roleURI="http://www.opko.com/role/DebtInputsUsedInLatticeModelDetails">
<link:definition> 2406404 - Disclosure - Debt - Inputs Used In Lattice Model (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtLinesOfCreditDetails" roleURI="http://www.opko.com/role/DebtLinesOfCreditDetails">
<link:definition> 2406406 - Disclosure - Debt - Lines Of Credit (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtMortgageNotesAndOtherDebtDetails" roleURI="http://www.opko.com/role/DebtMortgageNotesAndOtherDebtDetails">
<link:definition> 2406407 - Disclosure - Debt - Mortgage Notes And Other Debt (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtNarrativeDetails" roleURI="http://www.opko.com/role/DebtNarrativeDetails">
<link:definition> 2406402 - Disclosure - Debt - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtNotesDetails" roleURI="http://www.opko.com/role/DebtNotesDetails">
<link:definition> 2406403 - Disclosure - Debt - Notes (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DebtTables" roleURI="http://www.opko.com/role/DebtTables">
<link:definition> 2306301 - Disclosure - Debt (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DerivativeContracts" roleURI="http://www.opko.com/role/DerivativeContracts">
<link:definition> 2109100 - Disclosure - Derivative Contracts </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DerivativeContractsBalanceSheetComponentDetails" roleURI="http://www.opko.com/role/DerivativeContractsBalanceSheetComponentDetails">
<link:definition> 2409402 - Disclosure - Derivative Contracts - Balance Sheet Component (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DerivativeContractsDerivativeGainsLossesDetails" roleURI="http://www.opko.com/role/DerivativeContractsDerivativeGainsLossesDetails">
<link:definition> 2409403 - Disclosure - Derivative Contracts - Derivative Gains (Losses) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DerivativeContractsTables" roleURI="http://www.opko.com/role/DerivativeContractsTables">
<link:definition> 2309301 - Disclosure - Derivative Contracts (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DocumentAndEntityInformation" roleURI="http://www.opko.com/role/DocumentAndEntityInformation">
<link:definition> 0001000 - Document - Document and Entity Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsLossPerShare" roleURI="http://www.opko.com/role/EarningsLossPerShare">
<link:definition> 2103100 - Disclosure - Earnings (Loss) Per Share </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsLossPerShareNarrativeDetails" roleURI="http://www.opko.com/role/EarningsLossPerShareNarrativeDetails">
<link:definition> 2403403 - Disclosure - Earnings (Loss) Per Share - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsLossPerShareScheduleOfEarningsPerShareDetails" roleURI="http://www.opko.com/role/EarningsLossPerShareScheduleOfEarningsPerShareDetails">
<link:definition> 2403402 - Disclosure - Earnings (Loss) Per Share - Schedule of Earnings Per Share (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsLossPerShareTables" roleURI="http://www.opko.com/role/EarningsLossPerShareTables">
<link:definition> 2303301 - Disclosure - Earnings (Loss) Per Share (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurements" roleURI="http://www.opko.com/role/FairValueMeasurements">
<link:definition> 2108100 - Disclosure - Fair Value Measurements </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsAssetsAndLiabilitiesMeasuredAtFairValueDetails" roleURI="http://www.opko.com/role/FairValueMeasurementsAssetsAndLiabilitiesMeasuredAtFairValueDetails">
<link:definition> 2408403 - Disclosure - Fair Value Measurements - Assets And Liabilities Measured At Fair Value (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsLevel3ReconciliationDetails" roleURI="http://www.opko.com/role/FairValueMeasurementsLevel3ReconciliationDetails">
<link:definition> 2408405 - Disclosure - Fair Value Measurements - Level 3 Reconciliation (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsNarrativeDetails" roleURI="http://www.opko.com/role/FairValueMeasurementsNarrativeDetails">
<link:definition> 2408406 - Disclosure - Fair Value Measurements - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsNotesDetails" roleURI="http://www.opko.com/role/FairValueMeasurementsNotesDetails">
<link:definition> 2408404 - Disclosure - Fair Value Measurements - Notes (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsSummaryOfInvestmentsDetails" roleURI="http://www.opko.com/role/FairValueMeasurementsSummaryOfInvestmentsDetails">
<link:definition> 2408402 - Disclosure - Fair Value Measurements - Summary Of Investments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementsTables" roleURI="http://www.opko.com/role/FairValueMeasurementsTables">
<link:definition> 2308301 - Disclosure - Fair Value Measurements (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="RelatedPartyTransactions" roleURI="http://www.opko.com/role/RelatedPartyTransactions">
<link:definition> 2110100 - Disclosure - Related Party Transactions </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="RelatedPartyTransactionsDetails" roleURI="http://www.opko.com/role/RelatedPartyTransactionsDetails">
<link:definition> 2410401 - Disclosure - Related Party Transactions (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="Segments" roleURI="http://www.opko.com/role/Segments">
<link:definition> 2114100 - Disclosure - Segments </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SegmentsNarrativeDetails" roleURI="http://www.opko.com/role/SegmentsNarrativeDetails">
<link:definition> 2414402 - Disclosure - Segments - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SegmentsOperationsAndAssetsInformationDetails" roleURI="http://www.opko.com/role/SegmentsOperationsAndAssetsInformationDetails">
<link:definition> 2414403 - Disclosure - Segments - Operations and Assets Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SegmentsTables" roleURI="http://www.opko.com/role/SegmentsTables">
<link:definition> 2314301 - Disclosure - Segments (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="StrategicAlliances" roleURI="http://www.opko.com/role/StrategicAlliances">
<link:definition> 2112100 - Disclosure - Strategic Alliances </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="StrategicAlliancesDetails" roleURI="http://www.opko.com/role/StrategicAlliancesDetails">
<link:definition> 2412401 - Disclosure - Strategic Alliances (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SubsequentEvents" roleURI="http://www.opko.com/role/SubsequentEvents">
<link:definition> 2115100 - Disclosure - Subsequent Events </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SummaryOfSignificantAccountingPolicies" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPolicies">
<link:definition> 2102100 - Disclosure - Summary of Significant Accounting Policies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SummaryOfSignificantAccountingPoliciesDetails" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesDetails">
<link:definition> 2402402 - Disclosure - Summary of Significant Accounting Policies (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SummaryOfSignificantAccountingPoliciesPolicies" roleURI="http://www.opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies">
<link:definition> 2202201 - Disclosure - Summary of Significant Accounting Policies (Policies) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
</xsd:appinfo>
</xsd:annotation>
<xsd:element abstract="true" id="opk_ARNOMember" name="ARNOMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember" name="AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_AccruedClinicalTrialsCurrent" name="AccruedClinicalTrialsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_AllowanceForDoubtfulAccountsPolicyTextBlock" name="AllowanceForDoubtfulAccountsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_AutomobilesandAircraftMember" name="AutomobilesandAircraftMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_AvailableforSaleSecuritiesOwnershipPercentage" name="AvailableforSaleSecuritiesOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod" name="AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BankOfChileMember" name="BankOfChileMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BbvaBankMember" name="BbvaBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BiceBankMember" name="BiceBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BilbaoVizcayaBankMember" name="BilbaoVizcayaBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BioCardiaInc.Member" name="BioCardiaInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BioReferenceMember" name="BioReferenceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" name="BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecreaseTenPercent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" name="BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentLiabilitiesAccountsPayableandOtherCurrentLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_CURNAMember" name="CURNAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ChromaDexMember" name="ChromaDexMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ClarosMember" name="ClarosMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CocrystalMember" name="CocrystalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeAgreementAdditionalMilestonePayment" name="CollaborativeAgreementAdditionalMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeAgreementPeriodfromFirstCommercialSale" name="CollaborativeAgreementPeriodfromFirstCommercialSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangement.MaximumMilestonePayments" name="CollaborativeArrangement.MaximumMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementMilestonePayment" name="CollaborativeArrangementMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementMilestonePaymentReceived" name="CollaborativeArrangementMilestonePaymentReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementUpfrontPayment" name="CollaborativeArrangementUpfrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" name="CompositionOfCertainFinancialStatementCaptionsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" name="CompositionsOfCertainFinancialStatementCaptionsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ContingentConsiderationMember" name="ContingentConsiderationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" name="ConvertibleDebtFairValueDisclosuresExcludingEmbeddedDerivative" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_Corpbanca1Member" name="Corpbanca1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CostMethodInvestmentOwnershipPercentage" name="CostMethodInvestmentOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CostMethodInvestmentSharesPurchasedinPeriod" name="CostMethodInvestmentSharesPurchasedinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_Customer1Member" name="Customer1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentConvertibleConversionRightTriggered" name="DebtInstrumentConvertibleConversionRightTriggered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DebtInstrumentRollForward" name="DebtInstrumentRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentsNumberofFinancialInstitutions" name="DebtInstrumentsNumberofFinancialInstitutions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_DevelopmentandLicenseAgreementMember" name="DevelopmentandLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DiagnosticsMember" name="DiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DrFrostMember" name="DrFrostMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DrFrostandMrPfennigerMember" name="DrFrostandMrPfennigerMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EirGenPharmaLimitedMember" name="EirGenPharmaLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" name="EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EloxxPharmaceuticalsMember" name="EloxxPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" name="EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquityMethodInvestmentExcludingVariableInterestEntity" name="EquityMethodInvestmentExcludingVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquityMethodInvestmentSharesPurchasedInPeriod" name="EquityMethodInvestmentSharesPurchasedInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EquityMethodInvestmentVariableInterestEntity" name="EquityMethodInvestmentVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_EstadoBankMember" name="EstadoBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ExclusiveOptionMember" name="ExclusiveOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" name="FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" name="FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" name="FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FineTechMember" name="FineTechMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FrostRealEstateHoldingsLLCMember" name="FrostRealEstateHoldingsLLCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_InCellDxIncMember" name="InCellDxIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" name="IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNoncontrollingInterestNetofTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncreaseDecreaseinForeignCurrencyMeasurement" name="IncreaseDecreaseinForeignCurrencyMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_InterestExpenseNonoperating" name="InterestExpenseNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_InterestIncomeNonoperating" name="InterestIncomeNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ItauBankMember" name="ItauBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_JPMorganChaseMember" name="JPMorganChaseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LaunchandSalesbasedMilestonesMember" name="LaunchandSalesbasedMilestonesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment" name="LicenseandCollaborationAgreementsProceedsasUpFrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_LineofCreditAgreementIntercompanyLoanMaximum" name="LineofCreditAgreementIntercompanyLoanMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" name="LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" name="LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" name="LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" name="LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LondonInterbankOfferedRateLIBORThereafterMember" name="LondonInterbankOfferedRateLIBORThereafterMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MabVaxTherapeuticsHoldingsInc.Member" name="MabVaxTherapeuticsHoldingsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MuseumofScienceIncMember" name="MuseumofScienceIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NIMSMember" name="NIMSMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NeovascMember" name="NeovascMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NewCreditAgreementMember" name="NewCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NonInvasiveMonitoringSystemsInc.Member" name="NonInvasiveMonitoringSystemsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NotesDueFebruary12033Member" name="NotesDueFebruary12033Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_NumberofSalesEmployees" name="NumberofSalesEmployees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OPKOBiologicsMember" name="OPKOBiologicsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OPKOHealthEuropeMember" name="OPKOHealthEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OPKORentalMember" name="OPKORentalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearOne" name="OperatingLeasesMonthlyPaymentsYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearThree" name="OperatingLeasesMonthlyPaymentsYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_OpkoChileMember" name="OpkoChileMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OpkoDiagnosticsMember" name="OpkoDiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_PercentageOfIncreaseDecreaseInFutureSales" name="PercentageOfIncreaseDecreaseInFutureSales" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_PfizerMember" name="PfizerMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PharmaceuticalMember" name="PharmaceuticalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PharmsynthezMember" name="PharmsynthezMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PharmsynthezNoteReceivableMember" name="PharmsynthezNoteReceivableMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember" name="PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ProductRegistrationsMember" name="ProductRegistrationsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_RayaldeeMember" name="RayaldeeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_RegulatoryMilestonesMember" name="RegulatoryMilestonesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ReimbursementOfTravelExpenseMember" name="ReimbursementOfTravelExpenseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_RelatedPartyTransactionFutureContributions" name="RelatedPartyTransactionFutureContributions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_RelativeCoreMember" name="RelativeCoreMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_RevenueFromTransferOfIntellectualProperty" name="RevenueFromTransferOfIntellectualProperty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_RoyaltyRevenueObligationPeriod" name="RoyaltyRevenueObligationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_RxiMember" name="RxiMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_RxiPharmaceuticalsCorporationMember" name="RxiPharmaceuticalsCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SantanderBank2MemberMember" name="SantanderBank2MemberMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SantanderBankMember" name="SantanderBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ScotiabankMember" name="ScotiabankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SeriesIPreferredStockMember" name="SeriesIPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SevionMember" name="SevionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract" name="SharesIssuedintheConversionofStockandDebtInstrumentsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_SharesReceivedAsGift" name="SharesReceivedAsGift" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_SharesSurrenderedInLieuOfCashPayment" name="SharesSurrenderedInLieuOfCashPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" name="StockIssuedDuringPeriodSharesAcquisitionAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" name="StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" name="StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_StockOptionandWarrantInvestments" name="StockOptionandWarrantInvestments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_StrategicAlliancesTextBlock" name="StrategicAlliancesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_TaxesRecoverableCurrent" name="TaxesRecoverableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_TesaroMember" name="TesaroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" name="ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TransitionTherapeuticsInc.Member" name="TransitionTherapeuticsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_VBIVaccinesIncMember" name="VBIVaccinesIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ViforFreseniusMedicalCarePharmaLtdMember" name="ViforFreseniusMedicalCarePharmaLtdMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_XeneticBiosciencesInc.Member" name="XeneticBiosciencesInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ZebraMember" name="ZebraMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
</xsd:schema>

Top
Filing Submission 0000944809-17-000008   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Mon., Apr. 29, 10:53:24.1pm ET