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Opko Health, Inc. – ‘10-Q’ for 6/30/17 – ‘EX-101.LAB’

On:  Tuesday, 8/8/17, at 4:15pm ET   ·   For:  6/30/17   ·   Accession #:  944809-17-8   ·   File #:  1-33528

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  As Of               Filer                 Filing    For·On·As Docs:Size

 8/08/17  Opko Health, Inc.                 10-Q        6/30/17   75:8.9M

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    648K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     22K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     22K 
12: R1          Document and Entity Information                     HTML     40K 
13: R2          Condensed Consolidated Balance Sheets               HTML    100K 
14: R3          Condensed Consolidated Balance Sheets               HTML     30K 
                (Parenthetical)                                                  
15: R4          Condensed Consolidated Statements of Operations     HTML     94K 
16: R5          Condensed Consolidated Statements of Comprehensive  HTML     41K 
                Income (Loss)                                                    
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    124K 
18: R7          Business and Organization                           HTML     28K 
19: R8          Summary of Significant Accounting Policies          HTML     77K 
20: R9          Earnings (Loss) Per Share                           HTML     78K 
21: R10         Composition of Certain Financial Statement          HTML    122K 
                Captions                                                         
22: R11         Acquisitions, Investments and Licenses              HTML     60K 
23: R12         Debt                                                HTML    125K 
24: R13         Accumulated Other Comprehensive Income (Loss)       HTML     38K 
25: R14         Fair Value Measurements                             HTML    140K 
26: R15         Derivative Contracts                                HTML     54K 
27: R16         Related Party Transactions                          HTML     35K 
28: R17         Commitments and Contingencies                       HTML     32K 
29: R18         Strategic Alliances                                 HTML     50K 
30: R19         Segments                                            HTML    153K 
31: R20         Subsequent Events                                   HTML     23K 
32: R21         Summary of Significant Accounting Policies          HTML    136K 
                (Policies)                                                       
33: R22         Earnings (Loss) Per Share (Tables)                  HTML     72K 
34: R23         Composition of Certain Financial Statement          HTML    123K 
                Captions (Tables)                                                
35: R24         Acquisitions, Investments and Licenses (Tables)     HTML     48K 
36: R25         Debt (Tables)                                       HTML    110K 
37: R26         Accumulated Other Comprehensive Income (Loss)       HTML     38K 
                (Tables)                                                         
38: R27         Fair Value Measurements (Tables)                    HTML    141K 
39: R28         Derivative Contracts (Tables)                       HTML     55K 
40: R29         Segments (Tables)                                   HTML    151K 
41: R30         Business and Organization (Details)                 HTML     34K 
42: R31         Summary of Significant Accounting Policies          HTML    130K 
                (Details)                                                        
43: R32         Earnings (Loss) Per Share - Schedule of Earnings    HTML     59K 
                Per Share (Details)                                              
44: R33         Earnings (Loss) Per Share - Narrative (Details)     HTML     33K 
45: R34         Composition of Certain Financial Statement          HTML    138K 
                Captions (Details)                                               
46: R35         Composition of Certain Financial Statement          HTML     57K 
                Captions - Changes in Goodwill (Details)                         
47: R36         Acquisitions, Investments and Licenses -            HTML     32K 
                Acquisition Narrative (Details)                                  
48: R37         Acquisitions, Investments and Licenses -            HTML     44K 
                Transition Therapeutics Purchase Price Allocation                
                (Details)                                                        
49: R38         Acquisitions, Investments and Licenses - Summary    HTML     37K 
                of Investments (Details)                                         
50: R39         Acquisitions, Investments and Licenses - Equity     HTML     57K 
                and Cost Method Investments Narrative (Details)                  
51: R40         Acquisitions, Investments and Licenses - Available  HTML     51K 
                for Sale Investments, Sale of Investments and                    
                Warrants and Options Narrative (Details)                         
52: R41         Acquisitions, Investments and Licenses - Variable   HTML     33K 
                Interest Entities Narrative (Details)                            
53: R42         Acquisitions, Investments and Licenses - Other      HTML     40K 
                Narrative (Details)                                              
54: R43         Debt - Narrative (Details)                          HTML    143K 
55: R44         Debt - Notes (Details)                              HTML     51K 
56: R45         Debt - Inputs Used In Lattice Model (Details)       HTML     40K 
57: R46         Debt - Fair Value Of Embedded Derivatives           HTML     28K 
                (Details)                                                        
58: R47         Debt - Lines Of Credit (Details)                    HTML     60K 
59: R48         Debt - Mortgage Notes And Other Debt (Details)      HTML     31K 
60: R49         Accumulated Other Comprehensive Income (Loss)       HTML     43K 
                (Details)                                                        
61: R50         Fair Value Measurements - Summary Of Investments    HTML     35K 
                (Details)                                                        
62: R51         Fair Value Measurements - Assets And Liabilities    HTML     54K 
                Measured At Fair Value (Details)                                 
63: R52         Fair Value Measurements - Notes (Details)           HTML     29K 
64: R53         Fair Value Measurements - Level 3 Reconciliation    HTML     36K 
                (Details)                                                        
65: R54         Fair Value Measurements - Narrative (Details)       HTML     33K 
66: R55         Derivative Contracts - Balance Sheet Component      HTML     39K 
                (Details)                                                        
67: R56         Derivative Contracts - Derivative Gains (Losses)    HTML     32K 
                (Details)                                                        
68: R57         Related Party Transactions (Details)                HTML    164K 
69: R58         Commitments and Contingencies (Details)             HTML     36K 
70: R59         Strategic Alliances (Details)                       HTML    104K 
71: R60         Segments - Narrative (Details)                      HTML     41K 
72: R61         Segments - Operations and Assets Information        HTML     78K 
                (Details)                                                        
74: XML         IDEA XML File -- Filing Summary                      XML    132K 
73: EXCEL       IDEA Workbook of Financial Reports                  XLSX    106K 
 6: EX-101.INS  XBRL Instance -- opk-20170630                        XML   2.77M 
 8: EX-101.CAL  XBRL Calculations -- opk-20170630_cal                XML    251K 
 9: EX-101.DEF  XBRL Definitions -- opk-20170630_def                 XML    971K 
10: EX-101.LAB  XBRL Labels -- opk-20170630_lab                      XML   1.93M 
11: EX-101.PRE  XBRL Presentations -- opk-20170630_pre               XML   1.20M 
 7: EX-101.SCH  XBRL Schema -- opk-20170630                          XSD    180K 
75: ZIP         XBRL Zipped Folder -- 0000944809-17-000008-xbrl      Zip    290K

‘EX-101.LAB’   —   XBRL Labels — opk-20170630_lab

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<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_017A684EB1D5432F23F476581F704B36_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_017A684EB1D5432F23F476581F704B36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_5A3DD14D5DC732C3393A76581DC2377A_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_5A3DD14D5DC732C3393A76581DC2377A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
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<link:label id="lab_us-gaap_FairValueByAssetClassAxis_351140CD4D436471728176581DC27D9F_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis_351140CD4D436471728176581DC27D9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Asset Class [Axis] </link:label>
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<link:label id="lab_us-gaap_MoneyMarketFundsMember_6B3C0BF6E41E39F2BED776581DC26D33_verboseLabel_en-US" xlink:label="lab_us-gaap_MoneyMarketFundsMember_6B3C0BF6E41E39F2BED776581DC26D33" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Money market funds </link:label>
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<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis_AACFC4BA9BE600A3E1F376581DC32064" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_425EF75F8E354439F57276581DC3E4D0" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative Financial Instruments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmbeddedDerivativeFinancialInstrumentsMember" xlink:label="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D" xlink:to="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_64909D7F4FB5F4060AA476581DC3171D" xlink:type="arc"/>
<link:label id="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9_terseLabel_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9_label_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration [Member] </link:label>
<link:label id="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9_documentation_en-US" xlink:label="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Contingent consideration. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ContingentConsiderationMember" xlink:label="loc_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:to="lab_opk_ContingentConsiderationMember_6979960305B2FDCBF91376581DC319B9" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Hierarchy [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_F3ACDC7B5E189762F32976581DC30077" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements Fair Value Hierarchy [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Hierarchy [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D9F291B000C146097D4976581DC3250A" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Quoted prices in active markets for identical assets (Level 1) </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 1 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049" xlink:to="lab_us-gaap_FairValueInputsLevel1Member_E5478A5CD315F9DE948E76581DC33049" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Significant other observable inputs (Level 2) </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 2 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0" xlink:to="lab_us-gaap_FairValueInputsLevel2Member_359C0DD4ECCEDCCA821A76581DC3F7A0" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Significant unobservable inputs (Level 3) </link:label>
<link:label id="lab_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Inputs, Level 3 [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D" xlink:to="lab_us-gaap_FairValueInputsLevel3Member_8D78CD3005455E46750376581DC3284D" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_B442B833E76A380628EE76581DC31BC8" xlink:type="arc"/>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_05BD33A7EA8EBE82400976581DC3AC80_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_05BD33A7EA8EBE82400976581DC3AC80" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Assets: </link:label>
<link:label id="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_05BD33A7EA8EBE82400976581DC3AC80_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_05BD33A7EA8EBE82400976581DC3AC80" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial Instruments, Financial Assets, Balance Sheet Groupings [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_05BD33A7EA8EBE82400976581DC3AC80" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8" xlink:to="lab_us-gaap_AssetsFairValueDisclosure_D92FF61C275DDF23D4B276581DC370A8" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Fair Value Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_0A5B2F701DA4F5590A6576581DC42442" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial and Nonfinancial Liabilities, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure_D80A0CF6197C7117DBF276581DC4CAAD" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtDisclosureAbstract_E99453132BD11C180EE876581E5C0AB1_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureAbstract_E99453132BD11C180EE876581E5C0AB1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_E99453132BD11C180EE876581E5C0AB1" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentTable_3D3853D9C1140C3D6C5976581E5D7B28_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_3D3853D9C1140C3D6C5976581E5D7B28" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentTable_3D3853D9C1140C3D6C5976581E5D7B28_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable_3D3853D9C1140C3D6C5976581E5D7B28" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Long-term Debt Instruments [Table] </link:label>
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<link:label id="lab_us-gaap_LongtermDebtTypeAxis_B0B89DF068572EAA67B276581E5DEE50_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_B0B89DF068572EAA67B276581E5DEE50" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_B0B89DF068572EAA67B276581E5DEE50_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_B0B89DF068572EAA67B276581E5DEE50" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
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<link:label id="lab_us-gaap_LongtermDebtTypeDomain_2E9B1A5945A825AAA52C76581E5DBA60_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_2E9B1A5945A825AAA52C76581E5DBA60" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_2E9B1A5945A825AAA52C76581E5DBA60_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_2E9B1A5945A825AAA52C76581E5DBA60" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
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<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_53CF93D290001365BC9E76581E5DAF60_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_53CF93D290001365BC9E76581E5DAF60" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes </link:label>
<link:label id="lab_us-gaap_ConvertibleNotesPayableMember_53CF93D290001365BC9E76581E5DAF60_label_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember_53CF93D290001365BC9E76581E5DAF60" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_53CF93D290001365BC9E76581E5DAF60" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentAxis_9E4639FED2E309D3566076581E5DF9FC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_9E4639FED2E309D3566076581E5DF9FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentAxis_9E4639FED2E309D3566076581E5DF9FC_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_9E4639FED2E309D3566076581E5DF9FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_9E4639FED2E309D3566076581E5DF9FC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentNameDomain_9B989B032A4D95DDB39576581E5D9035_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_9B989B032A4D95DDB39576581E5D9035" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_9B989B032A4D95DDB39576581E5D9035_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_9B989B032A4D95DDB39576581E5D9035" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9B989B032A4D95DDB39576581E5D9035" xlink:type="locator"/>
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<link:label id="lab_opk_NotesDueFebruary12033Member_DEB6121D34586C00E9D976581E5DD095_terseLabel_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_DEB6121D34586C00E9D976581E5DD095" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 </link:label>
<link:label id="lab_opk_NotesDueFebruary12033Member_DEB6121D34586C00E9D976581E5DD095_label_en-US" xlink:label="lab_opk_NotesDueFebruary12033Member_DEB6121D34586C00E9D976581E5DD095" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Due February 1, 2033 [Member] </link:label>
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<link:loc xlink:href="opk-20170630.xsd#opk_NotesDueFebruary12033Member" xlink:label="loc_opk_NotesDueFebruary12033Member_DEB6121D34586C00E9D976581E5DD095" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentLineItems_A6A04D9144CB7785C53F76581E5D2F0A_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_A6A04D9144CB7785C53F76581E5D2F0A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_A6A04D9144CB7785C53F76581E5D2F0A_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_A6A04D9144CB7785C53F76581E5D2F0A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_A6A04D9144CB7785C53F76581E5D2F0A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SharePrice_AE8887C1FFEA853B56F276581E5DF8C0_verboseLabel_en-US" xlink:label="lab_us-gaap_SharePrice_AE8887C1FFEA853B56F276581E5DF8C0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Stock price (in dollars per share) </link:label>
<link:label id="lab_us-gaap_SharePrice_AE8887C1FFEA853B56F276581E5DF8C0_label_en-US" xlink:label="lab_us-gaap_SharePrice_AE8887C1FFEA853B56F276581E5DF8C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_AE8887C1FFEA853B56F276581E5DF8C0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Ratio </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_35C1DDFF4D520F88AABB76581E5D04DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_C0823ED4DB8307A4E11376581E5D463B_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_C0823ED4DB8307A4E11376581E5D463B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Conversion Price (in dollars per share) </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_C0823ED4DB8307A4E11376581E5D463B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_C0823ED4DB8307A4E11376581E5D463B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Price </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_C0823ED4DB8307A4E11376581E5D463B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_F8C0CFC52CC66C5CED0676581E5D5C02_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_F8C0CFC52CC66C5CED0676581E5D5C02" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maturity date </link:label>
<link:label id="lab_us-gaap_DebtInstrumentMaturityDate_F8C0CFC52CC66C5CED0676581E5D5C02_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentMaturityDate_F8C0CFC52CC66C5CED0676581E5D5C02" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Maturity Date </link:label>
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<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_DA2779B49FCBAB350AF976581E5D5BC6_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_DA2779B49FCBAB350AF976581E5D5BC6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Risk-free interest rate </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_DA2779B49FCBAB350AF976581E5D5BC6_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsRiskFreeInterestRate_DA2779B49FCBAB350AF976581E5D5BC6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Risk Free Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_DA2779B49FCBAB350AF976581E5D5BC6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_9EABDF05CA44B3C2B41B76581E5DBAB5_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_9EABDF05CA44B3C2B41B76581E5DBAB5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated stock volatility </link:label>
<link:label id="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_9EABDF05CA44B3C2B41B76581E5DBAB5_label_en-US" xlink:label="lab_us-gaap_FairValueAssumptionsExpectedVolatilityRate_9EABDF05CA44B3C2B41B76581E5DBAB5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Assumptions, Expected Volatility Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_9EABDF05CA44B3C2B41B76581E5DBAB5" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_8A022DA757B02F114A1976581E5E0095_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_8A022DA757B02F114A1976581E5E0095" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estimated credit spread </link:label>
<link:label id="lab_us-gaap_FairValueInputsEntityCreditRisk_8A022DA757B02F114A1976581E5E0095_label_en-US" xlink:label="lab_us-gaap_FairValueInputsEntityCreditRisk_8A022DA757B02F114A1976581E5E0095" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Entity Credit Risk </link:label>
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<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_Customer1Member_48CFAADC7257C9F167FE76581D67687C" xlink:to="lab_opk_Customer1Member_48CFAADC7257C9F167FE76581D67687C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_BBF6355E9D2D84D02CBD76581D670AFD_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_BBF6355E9D2D84D02CBD76581D670AFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_BBF6355E9D2D84D02CBD76581D670AFD_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_BBF6355E9D2D84D02CBD76581D670AFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_BBF6355E9D2D84D02CBD76581D670AFD" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConsolidationItemsDomain_BDA0D4889EEC7A48E7E476581D674354_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_BDA0D4889EEC7A48E7E476581D674354" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_BDA0D4889EEC7A48E7E476581D674354_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_BDA0D4889EEC7A48E7E476581D674354" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_BDA0D4889EEC7A48E7E476581D674354" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IntersegmentEliminationMember_2B078381574C57B49FCC76581D67F22B_verboseLabel_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_2B078381574C57B49FCC76581D67F22B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intersegment Elimination </link:label>
<link:label id="lab_us-gaap_IntersegmentEliminationMember_2B078381574C57B49FCC76581D67F22B_label_en-US" xlink:label="lab_us-gaap_IntersegmentEliminationMember_2B078381574C57B49FCC76581D67F22B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intersegment Eliminations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:label="loc_us-gaap_IntersegmentEliminationMember_2B078381574C57B49FCC76581D67F22B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_1A7037532BF1E44281D876581D678485_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_1A7037532BF1E44281D876581D678485" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_1A7037532BF1E44281D876581D678485_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_1A7037532BF1E44281D876581D678485" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_1A7037532BF1E44281D876581D678485" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_9D0C93F4CC4AC116051576581D67FD11_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_9D0C93F4CC4AC116051576581D67FD11" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_9D0C93F4CC4AC116051576581D67FD11_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_9D0C93F4CC4AC116051576581D67FD11" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_9D0C93F4CC4AC116051576581D67FD11" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_7B7B4B4FC5B8A32819CF76581D67BE2E_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_7B7B4B4FC5B8A32819CF76581D67BE2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk </link:label>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_7B7B4B4FC5B8A32819CF76581D67BE2E_label_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_7B7B4B4FC5B8A32819CF76581D67BE2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_7B7B4B4FC5B8A32819CF76581D67BE2E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_A42F846FE54682046CFC76581D6793C7_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_A42F846FE54682046CFC76581D6793C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_A42F846FE54682046CFC76581D6793C7_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_A42F846FE54682046CFC76581D6793C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_A42F846FE54682046CFC76581D6793C7" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_721823D62D11AF5E225876581D67A1E2_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_721823D62D11AF5E225876581D67A1E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_721823D62D11AF5E225876581D67A1E2_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain_721823D62D11AF5E225876581D67A1E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Benchmark [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_721823D62D11AF5E225876581D67A1E2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SalesRevenueNetMember_C0D6ED5B9A15D8C0D45576581D67C5DB_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_C0D6ED5B9A15D8C0D45576581D67C5DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetMember_C0D6ED5B9A15D8C0D45576581D67C5DB_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember_C0D6ED5B9A15D8C0D45576581D67C5DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Net [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_C0D6ED5B9A15D8C0D45576581D67C5DB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccountsReceivableMember_D1E6AD7C263E08E6304A76581D6815B0_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_D1E6AD7C263E08E6304A76581D6815B0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts Receivable </link:label>
<link:label id="lab_us-gaap_AccountsReceivableMember_D1E6AD7C263E08E6304A76581D6815B0_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableMember_D1E6AD7C263E08E6304A76581D6815B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_D1E6AD7C263E08E6304A76581D6815B0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_04CACABED54371CD172676581D689631_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_04CACABED54371CD172676581D689631" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_04CACABED54371CD172676581D689631_label_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_04CACABED54371CD172676581D689631" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_04CACABED54371CD172676581D689631" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NumberOfReportableSegments_34CE3EF329DEE2C542A176581D68FC4F_terseLabel_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_34CE3EF329DEE2C542A176581D68FC4F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of reportable segments </link:label>
<link:label id="lab_us-gaap_NumberOfReportableSegments_34CE3EF329DEE2C542A176581D68FC4F_label_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_34CE3EF329DEE2C542A176581D68FC4F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Reportable Segments </link:label>
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<link:label id="lab_us-gaap_Revenues_CD1AE560B7B22D6F884076581D68E6E5_verboseLabel_en-US" xlink:label="lab_us-gaap_Revenues_CD1AE560B7B22D6F884076581D68E6E5" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment sales </link:label>
<link:label id="lab_us-gaap_Revenues_CD1AE560B7B22D6F884076581D68E6E5_label_en-US" xlink:label="lab_us-gaap_Revenues_CD1AE560B7B22D6F884076581D68E6E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
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<link:label id="lab_us-gaap_InterestExpense_F37BC81A1896D5BBDB8676581D681A5F_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpense_F37BC81A1896D5BBDB8676581D681A5F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inter-segment allocation of interest expense </link:label>
<link:label id="lab_us-gaap_InterestExpense_F37BC81A1896D5BBDB8676581D681A5F_label_en-US" xlink:label="lab_us-gaap_InterestExpense_F37BC81A1896D5BBDB8676581D681A5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense </link:label>
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<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_9866BB3ADF520EB56AC076581D689578_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_9866BB3ADF520EB56AC076581D689578" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration percentage </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_9866BB3ADF520EB56AC076581D689578_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_9866BB3ADF520EB56AC076581D689578" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Percentage </link:label>
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<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_56C6BBEDD83DBE29642376581E0DE8DD_verboseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_56C6BBEDD83DBE29642376581E0DE8DD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ACCUMULATED OTHER COMPREHENSIVE INCOME (LOSS) </link:label>
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<link:label id="lab_opk_InCellDxIncMember_1E42B7928FC49CF05FE09FA27BE49F7E_terseLabel_en-US" xlink:label="lab_opk_InCellDxIncMember_1E42B7928FC49CF05FE09FA27BE49F7E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> InCellDx, Inc </link:label>
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<link:label id="lab_opk_RxiMember_E19CA9DC689E42DA0CB19FA27BE4B107_terseLabel_en-US" xlink:label="lab_opk_RxiMember_E19CA9DC689E42DA0CB19FA27BE4B107" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Rxi </link:label>
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<link:label id="lab_invest_InvestmentLineItems_41C3A858A883E32F337D9FA27BE40070_terseLabel_en-US" xlink:label="lab_invest_InvestmentLineItems_41C3A858A883E32F337D9FA27BE40070" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment [Line Items] </link:label>
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<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A_terseLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A_label_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A_documentation_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Available-for-Sale Securities, Ownership Percentage </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_537B6689712C512256579FA27BE57C3A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D12E87F63804087859F09FA27BE53C2A_verboseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D12E87F63804087859F09FA27BE53C2A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of shares into which warrants may be converted (in shares) </link:label>
<link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D12E87F63804087859F09FA27BE53C2A_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D12E87F63804087859F09FA27BE53C2A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Warrant or Right, Number of Securities Called by Warrants or Rights </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherThanTemporaryImpairmentLossesInvestmentsAvailableforsaleSecurities" xlink:label="loc_us-gaap_OtherThanTemporaryImpairmentLossesInvestmentsAvailableforsaleSecurities_B0783FE53443806C04699FA27BE56A0A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_CE71E08298426AD6C4EE76581D9CEB69_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_CE71E08298426AD6C4EE76581D9CEB69" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair Values and Presentation of Derivative Financial Instruments </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_CE71E08298426AD6C4EE76581D9CEB69" xlink:type="locator"/>
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<link:label id="lab_opk_DocumentAndEntityInformationAbstract_CC44B2D2960116DB322B76581FC10E86_label_en-US" xlink:label="lab_opk_DocumentAndEntityInformationAbstract_CC44B2D2960116DB322B76581FC10E86" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Document and Entity Information [Abstract] </link:label>
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<link:label id="lab_dei_EntityFilerCategory_D84A806DB9108481BB2A76581FC2BB07_label_en-US" xlink:label="lab_dei_EntityFilerCategory_D84A806DB9108481BB2A76581FC2BB07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Filer Category </link:label>
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<link:label id="lab_dei_EntityCommonStockSharesOutstanding_F21E4AA82C4A2C68118476581FC29863_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_F21E4AA82C4A2C68118476581FC29863" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:label id="lab_dei_EntityCommonStockSharesOutstanding_F21E4AA82C4A2C68118476581FC29863_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding_F21E4AA82C4A2C68118476581FC29863" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity Common Stock, Shares Outstanding </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_F21E4AA82C4A2C68118476581FC29863" xlink:type="locator"/>
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<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_87D9C1CCC34369FE723376581E202E8E_terseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_87D9C1CCC34369FE723376581E202E8E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_87D9C1CCC34369FE723376581E202E8E_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_87D9C1CCC34369FE723376581E202E8E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited, OPKO Europe and Bio Reference [Member] </link:label>
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<link:loc xlink:href="opk-20170630.xsd#opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember" xlink:label="loc_opk_EirGenPharmaLimitedOPKOEuropeandBioReferenceMember_87D9C1CCC34369FE723376581E202E8E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_08954596CC021337EB2276581E21D601_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_08954596CC021337EB2276581E21D601" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mortgage notes and other debt payables </link:label>
<link:label id="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_08954596CC021337EB2276581E21D601_label_en-US" xlink:label="lab_us-gaap_LongTermDebtByCurrentAndNoncurrentAbstract_08954596CC021337EB2276581E21D601" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, by Current and Noncurrent [Abstract] </link:label>
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<link:label id="lab_us-gaap_LongTermDebtCurrent_86E2857462DC801CEB7276581E210F3D_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_86E2857462DC801CEB7276581E210F3D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of notes payable </link:label>
<link:label id="lab_us-gaap_LongTermDebtCurrent_86E2857462DC801CEB7276581E210F3D_label_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_86E2857462DC801CEB7276581E210F3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_86E2857462DC801CEB7276581E210F3D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebtNoncurrent_D1A10D910191610464CC76581E21A5CA_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_D1A10D910191610464CC76581E21A5CA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other long-term liabilities </link:label>
<link:label id="lab_us-gaap_LongTermDebtNoncurrent_D1A10D910191610464CC76581E21A5CA_label_en-US" xlink:label="lab_us-gaap_LongTermDebtNoncurrent_D1A10D910191610464CC76581E21A5CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Excluding Current Maturities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_D1A10D910191610464CC76581E21A5CA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebt_18D154AC770E26A958DA76581E219923_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_18D154AC770E26A958DA76581E219923" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total </link:label>
<link:label id="lab_us-gaap_LongTermDebt_18D154AC770E26A958DA76581E219923_label_en-US" xlink:label="lab_us-gaap_LongTermDebt_18D154AC770E26A958DA76581E219923" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_18D154AC770E26A958DA76581E219923" xlink:type="locator"/>
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<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_5BEF2BED87D04EAAFDC476581DA59E70_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_5BEF2BED87D04EAAFDC476581DA59E70" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_5BEF2BED87D04EAAFDC476581DA59E70_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationTable_5BEF2BED87D04EAAFDC476581DA59E70" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] </link:label>
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<link:label id="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_F776F0F285FF18EA747976581DA5BF11_verboseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFinancialInstrumentsMember_F776F0F285FF18EA747976581DA5BF11" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option </link:label>
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<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_035CE6BE565D38F7B3BD76581DA52007_terseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationLineItems_035CE6BE565D38F7B3BD76581DA52007" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] </link:label>
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<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_E75A7722730FADB9CAB076581DA5F463_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_E75A7722730FADB9CAB076581DA5F463" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
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<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_F37C33F1D21AE0CEA05976581DA64287_label_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_F37C33F1D21AE0CEA05976581DA64287" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:label id="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_F37C33F1D21AE0CEA05976581DA64287_documentation_en-US" xlink:label="lab_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_F37C33F1D21AE0CEA05976581DA64287" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Foreign Currency Impact </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact" xlink:label="loc_opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact_F37C33F1D21AE0CEA05976581DA64287" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_1CB27A6E9C55B3B4AD847662B456ACB8_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_1CB27A6E9C55B3B4AD847662B456ACB8" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Payments </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_1CB27A6E9C55B3B4AD847662B456ACB8_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_1CB27A6E9C55B3B4AD847662B456ACB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_1CB27A6E9C55B3B4AD847662B456ACB8" xlink:type="locator"/>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_05ACF0E28774B3E464D876581DA691EE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityTable_900CB6662979B6458963B5A67644B012_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_900CB6662979B6458963B5A67644B012" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_900CB6662979B6458963B5A67644B012_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_900CB6662979B6458963B5A67644B012" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_900CB6662979B6458963B5A67644B012" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_A305D859FA1EC978B419B5A67644757D_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_A305D859FA1EC978B419B5A67644757D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityAxis_A305D859FA1EC978B419B5A67644757D_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityAxis_A305D859FA1EC978B419B5A67644757D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Lender Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_A305D859FA1EC978B419B5A67644757D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Lender [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5" xlink:to="lab_us-gaap_LineOfCreditFacilityLenderDomain_BE2CC3125816F65225FFB5A6764A78A5" xlink:type="arc"/>
<link:label id="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB_terseLabel_en-US" xlink:label="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> JPMorgan Chase </link:label>
<link:label id="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB_label_en-US" xlink:label="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> JP Morgan Chase [Member] </link:label>
<link:label id="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB_documentation_en-US" xlink:label="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> JP Morgan Chase [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_JPMorganChaseMember" xlink:label="loc_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:to="lab_opk_JPMorganChaseMember_C5152AD722B776031248B5A6764A75DB" xlink:type="arc"/>
<link:label id="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6_verboseLabel_en-US" xlink:label="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Itau Bank </link:label>
<link:label id="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6_label_en-US" xlink:label="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Itau Bank [Member] </link:label>
<link:label id="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6_documentation_en-US" xlink:label="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Itau. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ItauBankMember" xlink:label="loc_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:to="lab_opk_ItauBankMember_539E51676967728ECEE2B5A6764A03C6" xlink:type="arc"/>
<link:label id="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0_verboseLabel_en-US" xlink:label="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Bank of Chile </link:label>
<link:label id="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0_label_en-US" xlink:label="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bank of Chile [Member] </link:label>
<link:label id="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0_documentation_en-US" xlink:label="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bank of Chile. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BankOfChileMember" xlink:label="loc_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:to="lab_opk_BankOfChileMember_4666482A157660FF57A5B5A6764AC0D0" xlink:type="arc"/>
<link:label id="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6_verboseLabel_en-US" xlink:label="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BICE Bank </link:label>
<link:label id="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6_label_en-US" xlink:label="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bice Bank [Member] </link:label>
<link:label id="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6_documentation_en-US" xlink:label="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BICE Bank. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BiceBankMember" xlink:label="loc_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:to="lab_opk_BiceBankMember_4C4F9A5CCBDBFE5556BEB5A6764A1DF6" xlink:type="arc"/>
<link:label id="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008_verboseLabel_en-US" xlink:label="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> BBVA Bank </link:label>
<link:label id="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008_label_en-US" xlink:label="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> BBVA Bank [Member] </link:label>
<link:label id="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008_documentation_en-US" xlink:label="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> BBVA bank. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BbvaBankMember" xlink:label="loc_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:to="lab_opk_BbvaBankMember_E5FECCA818FC2B8194DEB5A6764AE008" xlink:type="arc"/>
<link:label id="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F_verboseLabel_en-US" xlink:label="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Estado Bank </link:label>
<link:label id="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F_label_en-US" xlink:label="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Estado Bank [Member] </link:label>
<link:label id="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F_documentation_en-US" xlink:label="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estado bank. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_EstadoBankMember" xlink:label="loc_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:to="lab_opk_EstadoBankMember_4460405A86AD49843398B5A6764AE98F" xlink:type="arc"/>
<link:label id="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F_terseLabel_en-US" xlink:label="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Santander Bank </link:label>
<link:label id="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F_label_en-US" xlink:label="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Santander Bank [Member] </link:label>
<link:label id="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F_documentation_en-US" xlink:label="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> santander Bank. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_SantanderBankMember" xlink:label="loc_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:to="lab_opk_SantanderBankMember_17CE364DDA8E6127795CB5A6764AD19F" xlink:type="arc"/>
<link:label id="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E_terseLabel_en-US" xlink:label="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Scotiabank </link:label>
<link:label id="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E_label_en-US" xlink:label="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Scotiabank [Member] </link:label>
<link:label id="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E_documentation_en-US" xlink:label="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Scotiabank [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ScotiabankMember" xlink:label="loc_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:to="lab_opk_ScotiabankMember_386AD5EAEFC4C97E43CBB5A6764B793E" xlink:type="arc"/>
<link:label id="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE_terseLabel_en-US" xlink:label="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corpbanca </link:label>
<link:label id="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE_label_en-US" xlink:label="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corpbanca1 [Member] </link:label>
<link:label id="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE_documentation_en-US" xlink:label="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Corpbanca1 [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_Corpbanca1Member" xlink:label="loc_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:to="lab_opk_Corpbanca1Member_EC4CF6D232B652F31C17B5A6764B6FBE" xlink:type="arc"/>
<link:label id="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D_verboseLabel_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Banco Bilbao Vizcaya </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D_label_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bilbao Vizcaya Bank [Member] </link:label>
<link:label id="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D_documentation_en-US" xlink:label="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Bilbao vizcaya bank. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BilbaoVizcayaBankMember" xlink:label="loc_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:to="lab_opk_BilbaoVizcayaBankMember_FFC944F61B6CD2A1C5A6B5A6764B325D" xlink:type="arc"/>
<link:label id="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA_terseLabel_en-US" xlink:label="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Santander Bank </link:label>
<link:label id="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA_label_en-US" xlink:label="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Santander Bank2 [Member] [Member] </link:label>
<link:label id="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA_documentation_en-US" xlink:label="lab_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Santander Bank2 [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_SantanderBank2MemberMember" xlink:label="loc_opk_SantanderBank2MemberMember_AD1CA3D3FBF4E5F6127DB5A6764BADBA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_28F3C2FDBB387261689BB5A6764B0D51_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_28F3C2FDBB387261689BB5A6764B0D51" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_28F3C2FDBB387261689BB5A6764B0D51_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_28F3C2FDBB387261689BB5A6764B0D51" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_28F3C2FDBB387261689BB5A6764B0D51" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_7AD81CB2E36F13E05715B5A6764BF703_verboseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_7AD81CB2E36F13E05715B5A6764BF703" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on borrowings at June 30, 2017 </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_7AD81CB2E36F13E05715B5A6764BF703_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_7AD81CB2E36F13E05715B5A6764BF703" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Interest Rate at Period End </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_7AD81CB2E36F13E05715B5A6764BF703" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_920C4D279FDA9379496FB5A6764B1135_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_920C4D279FDA9379496FB5A6764B1135" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit line capacity </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_920C4D279FDA9379496FB5A6764B1135_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_920C4D279FDA9379496FB5A6764B1135" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Maximum Borrowing Capacity </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_920C4D279FDA9379496FB5A6764B1135" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Outstanding </link:label>
<link:label id="lab_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F_label_en-US" xlink:label="lab_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F" xlink:to="lab_us-gaap_LineOfCredit_A78CB1D392B6D8560844B5A6764B561F" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_13AA3EDC30D802DA467584FBEFDAA64E_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_13AA3EDC30D802DA467584FBEFDAA64E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_13AA3EDC30D802DA467584FBEFDAA64E_label_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_13AA3EDC30D802DA467584FBEFDAA64E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_13AA3EDC30D802DA467584FBEFDAA64E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ClassOfStockDomain_F7F3815E650CD202970B84FBEFDAB5BD_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_F7F3815E650CD202970B84FBEFDAB5BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:label id="lab_us-gaap_ClassOfStockDomain_F7F3815E650CD202970B84FBEFDAB5BD_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_F7F3815E650CD202970B84FBEFDAB5BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
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<link:label id="lab_us-gaap_CommonStockMember_155B9BDA77EB582D9DC484FBEFDAA53D_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_155B9BDA77EB582D9DC484FBEFDAA53D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_155B9BDA77EB582D9DC484FBEFDAA53D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_VariableRateAxis_B509C504D9B4073497EC84FBEFDAEBBA_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis_B509C504D9B4073497EC84FBEFDAEBBA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:label id="lab_us-gaap_VariableRateAxis_B509C504D9B4073497EC84FBEFDAEBBA_label_en-US" xlink:label="lab_us-gaap_VariableRateAxis_B509C504D9B4073497EC84FBEFDAEBBA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_B509C504D9B4073497EC84FBEFDAEBBA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_VariableRateDomain_E1990062DB2AA91DE0D684FBEFDAC5A4_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain_E1990062DB2AA91DE0D684FBEFDAC5A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:label id="lab_us-gaap_VariableRateDomain_E1990062DB2AA91DE0D684FBEFDAC5A4_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain_E1990062DB2AA91DE0D684FBEFDAC5A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_E1990062DB2AA91DE0D684FBEFDAC5A4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2E7C308C97835260980E84FBEFDAFF3D_terseLabel_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2E7C308C97835260980E84FBEFDAFF3D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR </link:label>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2E7C308C97835260980E84FBEFDAFF3D_label_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_2E7C308C97835260980E84FBEFDAFF3D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_2E7C308C97835260980E84FBEFDAFF3D" xlink:type="locator"/>
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<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsMember_8E8B89FA4A8D9ECF71C484FBEFDA3B14" xlink:type="locator"/>
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<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR Thereafter </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LondonInterbankOfferedRateLIBORThereafterMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterMember_26B9935E6E30CE5E8D8D84FBEFDA4C13" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), First Twelve Months, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORFirstTwelveMonthsAdjustedforEurocurrencyLiabilitiesMember_AB04E8B11101E641B92C84FBEFDBD2E8" xlink:type="arc"/>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB_terseLabel_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR, Thereafter, Adjusted for Eurocurrency Liabilities </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB_label_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:label id="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB_documentation_en-US" xlink:label="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR), Thereafter, Adjusted for Eurocurrency Liabilities [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember" xlink:label="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:to="lab_opk_LondonInterbankOfferedRateLIBORThereafterAdjustedforEurocurrencyLiabilitiesMember_ABA7C6EC2D9B279B9F3184FBEFDB9BAB" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:label id="lab_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99_label_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99" xlink:to="lab_us-gaap_CreditFacilityAxis_A0118BCB4C0443F8D68584FBEFDB1F99" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:label id="lab_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81_label_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81" xlink:to="lab_us-gaap_CreditFacilityDomain_495C3AE7004FC440A44384FBEFDBAD81" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765_terseLabel_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility </link:label>
<link:label id="lab_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765_label_en-US" xlink:label="lab_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revolving Credit Facility [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765" xlink:to="lab_us-gaap_RevolvingCreditFacilityMember_9F86AE044890455EC9BD84FBEFDBC765" xlink:type="arc"/>
<link:label id="lab_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014_terseLabel_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Swingline </link:label>
<link:label id="lab_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014_label_en-US" xlink:label="lab_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bridge Loan [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BridgeLoanMember" xlink:label="loc_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014" xlink:to="lab_us-gaap_BridgeLoanMember_5E0A37407D345F2302F284FBEFDB6014" xlink:type="arc"/>
<link:label id="lab_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772_terseLabel_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Letter of Credit </link:label>
<link:label id="lab_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772_label_en-US" xlink:label="lab_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Letter of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LetterOfCreditMember" xlink:label="loc_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772" xlink:to="lab_us-gaap_LetterOfCreditMember_FAA15C5E449E66C54C8284FBEFDB3772" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Convertible Debt </link:label>
<link:label id="lab_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Debt [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73" xlink:to="lab_us-gaap_ConvertibleDebtMember_64CB821B960C41229FB984FBEFDB9D73" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit </link:label>
<link:label id="lab_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49_label_en-US" xlink:label="lab_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49" xlink:to="lab_us-gaap_LineOfCreditMember_D753CCE4A0DD404510F484FBEFDB0B49" xlink:type="arc"/>
<link:label id="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031_terseLabel_en-US" xlink:label="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Credit Agreement </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031_label_en-US" xlink:label="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:label id="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031_documentation_en-US" xlink:label="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> New Credit Agreement [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_NewCreditAgreementMember" xlink:label="loc_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:to="lab_opk_NewCreditAgreementMember_5CAD2A841241E22422E484FBEFDB6031" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_EE5AD8F826A6F523271984FBEFDB4957_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_EE5AD8F826A6F523271984FBEFDB4957" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_EE5AD8F826A6F523271984FBEFDB4957_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_EE5AD8F826A6F523271984FBEFDB4957" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_EE5AD8F826A6F523271984FBEFDB4957" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E0FDB6EDE4960227308084FBEFDB79D4_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E0FDB6EDE4960227308084FBEFDB79D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E0FDB6EDE4960227308084FBEFDB79D4_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_E0FDB6EDE4960227308084FBEFDB79D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_E0FDB6EDE4960227308084FBEFDB79D4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> On or after February 1, 2017 and before February 1, 2019 </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period One [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_445802AF268CEB60F18484FBEFDB48FC" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> On or after February 1, 2019 </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption, Period Two [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_2A8178C2D93D01BB8D5084FBEFDCA190" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359_terseLabel_en-US" xlink:label="lab_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:label id="lab_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359_label_en-US" xlink:label="lab_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359" xlink:to="lab_us-gaap_RangeAxis_151BB7C59F66F536397684FBEFDC0359" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC_terseLabel_en-US" xlink:label="lab_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:label id="lab_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC_label_en-US" xlink:label="lab_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC" xlink:to="lab_us-gaap_RangeMember_B8F89DE9826C944CD38F84FBEFDC81BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A_terseLabel_en-US" xlink:label="lab_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Minimum </link:label>
<link:label id="lab_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A_label_en-US" xlink:label="lab_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Minimum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A" xlink:to="lab_us-gaap_MinimumMember_4A960CDD9276DBF778E984FBEFDC6B1A" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum </link:label>
<link:label id="lab_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F_label_en-US" xlink:label="lab_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Maximum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F" xlink:to="lab_us-gaap_MaximumMember_F950BC284ED8BD153D6084FBEFDC674F" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350_verboseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350_label_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:label id="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350_documentation_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:to="lab_opk_OPKOHealthEuropeMember_78D03E8CB928BC965C9F84FBEFDC5350" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Debt face amount </link:label>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Face Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A" xlink:to="lab_us-gaap_DebtInstrumentFaceAmount_A08D2CE9F4A0D862242A84FBEFDC1E9A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on notes payable </link:label>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Interest Rate, Stated Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_49A707B6E0A9C247CDAE84FBEFDC9C7E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equivalent redemption price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Redemption Price, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPricePercentage_8181FA50B250EF20211884FBEFDCE930" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_1EB83E856FBC852C18D384FBEFDD5E88_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_1EB83E856FBC852C18D384FBEFDD5E88" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion price per share (in dollars per share) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_1EB83E856FBC852C18D384FBEFDD5E88" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_1EB83E856FBC852C18D384FBEFDD5E88" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_1EB83E856FBC852C18D384FBEFDD5E88" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Convertible debt, threshold percentage of stock price trigger </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_12B57784A34514249C7C84FBEFDDAA28" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of trading days </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_DD6FCA414750384C876484FBEFDD2B93" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8F2A6BDA41BE24275ECD84FBEFDDC1E1_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8F2A6BDA41BE24275ECD84FBEFDDC1E1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Conversion rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8F2A6BDA41BE24275ECD84FBEFDDC1E1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_8F2A6BDA41BE24275ECD84FBEFDDC1E1" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_8F2A6BDA41BE24275ECD84FBEFDDC1E1" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of consecutive trading days applicable conversion price </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Threshold Consecutive Trading Days </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_C1D514821269706AC83784FBEFDD7287" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_5EECD4ABD5F2225E17D384FBEFDDE5AF_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_5EECD4ABD5F2225E17D384FBEFDDE5AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Converted debt amount </link:label>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_5EECD4ABD5F2225E17D384FBEFDDE5AF_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_5EECD4ABD5F2225E17D384FBEFDDE5AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Converted Instrument, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_5EECD4ABD5F2225E17D384FBEFDDE5AF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_ED859BBEE543D53136A384FBEFDD317C_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_ED859BBEE543D53136A384FBEFDD317C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued on converted debt (in shares) </link:label>
<link:label id="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_ED859BBEE543D53136A384FBEFDD317C_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_ED859BBEE543D53136A384FBEFDD317C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Conversion, Converted Instrument, Shares Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_ED859BBEE543D53136A384FBEFDD317C" xlink:type="locator"/>
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<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Conversion right triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2_label_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:label id="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2_documentation_en-US" xlink:label="lab_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Conversion Right Triggered </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DebtInstrumentConvertibleConversionRightTriggered" xlink:label="loc_opk_DebtInstrumentConvertibleConversionRightTriggered_1EC94862ED2F17E644F384FBEFDD3CC2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_88A34B297553EB930FD484FBEFDD4910_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_88A34B297553EB930FD484FBEFDD4910" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock trigger price (in dollars per share) </link:label>
<link:label id="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_88A34B297553EB930FD484FBEFDD4910_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_88A34B297553EB930FD484FBEFDD4910" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Convertible, Stock Price Trigger </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentConvertibleStockPriceTrigger" xlink:label="loc_us-gaap_DebtInstrumentConvertibleStockPriceTrigger_88A34B297553EB930FD484FBEFDD4910" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebt_E55DB4ED99A1F77EDB3584FBEFDDC3BB_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_E55DB4ED99A1F77EDB3584FBEFDDC3BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_E55DB4ED99A1F77EDB3584FBEFDDC3BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_E55DB4ED99A1F77EDB3584FBEFDDC3BB" xlink:to="lab_us-gaap_LongTermDebt_E55DB4ED99A1F77EDB3584FBEFDDC3BB" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Change in FV of embedded derivative income </link:label>
<link:label id="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Embedded Derivative, Gain (Loss) on Embedded Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37" xlink:to="lab_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_721BBD506A2B9978F0B984FBEFDDDE37" xlink:type="arc"/>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354_terseLabel_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Higher borrowing capacity option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354_label_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:label id="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354_documentation_en-US" xlink:label="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Accordion Feature, Higher Borrowing Capacity Option </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption" xlink:label="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:to="lab_opk_LineofCreditFacilityAccordionFeatureHigherBorrowingCapacityOption_9FBD38AD4B4E26311D8384FBEFDDE354" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Basis spread on variable rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Basis Spread on Variable Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839" xlink:to="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4AE9F36280485C7DC48984FBEFDD7839" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Commitment fee percentage </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility, Commitment Fee Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F" xlink:to="lab_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_097EB8BA2D0511C7C7E484FBEFDDF17F" xlink:type="arc"/>
<link:label id="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF_terseLabel_en-US" xlink:label="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum intercompany loan </link:label>
<link:label id="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF_label_en-US" xlink:label="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Agreement, Intercompany Loan, Maximum </link:label>
<link:label id="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF_documentation_en-US" xlink:label="lab_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Line of Credit Agreement, Intercompany Loan, Maximum </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LineofCreditAgreementIntercompanyLoanMaximum" xlink:label="loc_opk_LineofCreditAgreementIntercompanyLoanMaximum_714E88E1A0466A1BAA4384FBEFDD1CAF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net assets </link:label>
<link:label id="lab_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B" xlink:to="lab_us-gaap_StockholdersEquity_59965A73DB12C3246F0084FBEFDD988B" xlink:type="arc"/>
<link:label id="lab_us-gaap_Goodwill_7F23B3DCB7845571D8C484FBEFDD1AED_verboseLabel_en-US" xlink:label="lab_us-gaap_Goodwill_7F23B3DCB7845571D8C484FBEFDD1AED" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_7F23B3DCB7845571D8C484FBEFDD1AED" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_DC2F170F7A416C0EB72C84FBEFDD0BF9_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_DC2F170F7A416C0EB72C84FBEFDD0BF9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_DC2F170F7A416C0EB72C84FBEFDD0BF9_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_DC2F170F7A416C0EB72C84FBEFDD0BF9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets, Net (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_DC2F170F7A416C0EB72C84FBEFDD0BF9" xlink:type="locator"/>
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<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32_verboseLabel_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of financial institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32_label_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instruments, Number of Financial Institutions </link:label>
<link:label id="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32_documentation_en-US" xlink:label="lab_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of financial institutions. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DebtInstrumentsNumberofFinancialInstitutions" xlink:label="loc_opk_DebtInstrumentsNumberofFinancialInstitutions_6E7B046DD26DDE95762E84FBEFDDCD32" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_B72978E26EB4D30DAD6184FBEFDD4261_terseLabel_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_B72978E26EB4D30DAD6184FBEFDD4261" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average interest rate </link:label>
<link:label id="lab_us-gaap_DebtWeightedAverageInterestRate_B72978E26EB4D30DAD6184FBEFDD4261_label_en-US" xlink:label="lab_us-gaap_DebtWeightedAverageInterestRate_B72978E26EB4D30DAD6184FBEFDD4261" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt, Weighted Average Interest Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_B72978E26EB4D30DAD6184FBEFDD4261" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_1F5C108EA178E3EFC63C76581E064726_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_1F5C108EA178E3EFC63C76581E064726" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in Accumulated Other Comprehensive Income (Loss), Net of Tax </link:label>
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<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_CBFFA6D3E47485A09290A368F55ECF7C_verboseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_CBFFA6D3E47485A09290A368F55ECF7C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock warrant and common stock options exercised (in shares) </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_CBFFA6D3E47485A09290A368F55ECF7C_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised_CBFFA6D3E47485A09290A368F55ECF7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Stock Options and Warrants Exercised </link:label>
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<link:label id="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_84B9256D3F85BF0E85B6A368F55F4484_totalLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment_84B9256D3F85BF0E85B6A368F55F4484" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Number of common stock issued for stock warrant and stock options exercised (in shares) </link:label>
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<link:label id="lab_opk_SharesSurrenderedInLieuOfCashPayment_330D739A85D77445A415A368F55F6A45_verboseLabel_en-US" xlink:label="lab_opk_SharesSurrenderedInLieuOfCashPayment_330D739A85D77445A415A368F55F6A45" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Shares surrendered in lieu of cash payment (in shares) </link:label>
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<link:label id="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_FC6B3B82B23E507BDC1C76581D766D7C_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_FC6B3B82B23E507BDC1C76581D766D7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] </link:label>
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<link:label id="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE_label_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:label id="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE_documentation_en-US" xlink:label="lab_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez Note Receivable [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_PharmsynthezNoteReceivableMember" xlink:label="loc_opk_PharmsynthezNoteReceivableMember_2BB23BC80754B856023076581D77A1CE" xlink:type="locator"/>
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<link:label id="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697_terseLabel_en-US" xlink:label="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmsynthez </link:label>
<link:label id="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697_label_en-US" xlink:label="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:label id="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697_documentation_en-US" xlink:label="lab_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmsynthez [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_PharmsynthezMember" xlink:label="loc_opk_PharmsynthezMember_0692E37B338FE5BE358276581D770697" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccruedLiabilitiesMember_A4EE354B6C09EA0583B676581D783A50_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesMember_A4EE354B6C09EA0583B676581D783A50" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued Expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedLiabilitiesMember" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_A4EE354B6C09EA0583B676581D783A50" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CounterpartyNameAxis_52C13AF5A9FB8B782D4376581D78F562_terseLabel_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_52C13AF5A9FB8B782D4376581D78F562" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:label id="lab_us-gaap_CounterpartyNameAxis_52C13AF5A9FB8B782D4376581D78F562_label_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_52C13AF5A9FB8B782D4376581D78F562" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_52C13AF5A9FB8B782D4376581D78F562" xlink:type="locator"/>
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<link:label id="lab_opk_ViforFreseniusMedicalCarePharmaLtdMember_28499C9C75CA4617E0B676581D783749_terseLabel_en-US" xlink:label="lab_opk_ViforFreseniusMedicalCarePharmaLtdMember_28499C9C75CA4617E0B676581D783749" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> VFMCRP </link:label>
<link:label id="lab_opk_ViforFreseniusMedicalCarePharmaLtdMember_28499C9C75CA4617E0B676581D783749_label_en-US" xlink:label="lab_opk_ViforFreseniusMedicalCarePharmaLtdMember_28499C9C75CA4617E0B676581D783749" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Vifor Fresenius Medical Care Pharma Ltd [Member] </link:label>
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<link:label id="lab_opk_PfizerMember_91F9A27874E8F883F06076581D78867D_terseLabel_en-US" xlink:label="lab_opk_PfizerMember_91F9A27874E8F883F06076581D78867D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pfizer </link:label>
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<link:label id="lab_opk_TesaroMember_82F24F8216C1130F4C6176581D787850_terseLabel_en-US" xlink:label="lab_opk_TesaroMember_82F24F8216C1130F4C6176581D787850" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Tesaro </link:label>
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<link:label id="lab_us-gaap_TypeOfArrangementAxis_51634DBE6A5817ABB43276581D78EB5E_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_51634DBE6A5817ABB43276581D78EB5E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_51634DBE6A5817ABB43276581D78EB5E_label_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_51634DBE6A5817ABB43276581D78EB5E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
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<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_F836902FC86C8F5B1EA176581D78D820_terseLabel_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_F836902FC86C8F5B1EA176581D78D820" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_F836902FC86C8F5B1EA176581D78D820_label_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_F836902FC86C8F5B1EA176581D78D820" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_F836902FC86C8F5B1EA176581D78D820" xlink:type="locator"/>
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<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617_terseLabel_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Development and License Agreement </link:label>
<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617_label_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Development and License Agreement [Member] </link:label>
<link:label id="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617_documentation_en-US" xlink:label="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Development and License Agreement [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DevelopmentandLicenseAgreementMember" xlink:label="loc_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:to="lab_opk_DevelopmentandLicenseAgreementMember_C163B1E59E565E04869A76581D784617" xlink:type="arc"/>
<link:label id="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04_terseLabel_en-US" xlink:label="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Regulatory Milestones </link:label>
<link:label id="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04_label_en-US" xlink:label="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Regulatory Milestones [Member] </link:label>
<link:label id="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04_documentation_en-US" xlink:label="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Regulatory Milestones [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_RegulatoryMilestonesMember" xlink:label="loc_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:to="lab_opk_RegulatoryMilestonesMember_1C5CEC76A8532B03C23D76581D788F04" xlink:type="arc"/>
<link:label id="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F_terseLabel_en-US" xlink:label="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Launch and Sales-based Milestones </link:label>
<link:label id="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F_label_en-US" xlink:label="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Launch and Sales-based Milestones [Member] </link:label>
<link:label id="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F_documentation_en-US" xlink:label="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Launch and Sales-based Milestones [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LaunchandSalesbasedMilestonesMember" xlink:label="loc_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:to="lab_opk_LaunchandSalesbasedMilestonesMember_CF0B85B8A4EF32F8070476581D78D96F" xlink:type="arc"/>
<link:label id="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3_terseLabel_en-US" xlink:label="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Exclusive Option </link:label>
<link:label id="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3_label_en-US" xlink:label="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Exclusive Option [Member] </link:label>
<link:label id="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3_documentation_en-US" xlink:label="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Exclusive Option [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ExclusiveOptionMember" xlink:label="loc_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:to="lab_opk_ExclusiveOptionMember_640818DB0DE4DB261B4A76581D7810E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_510C4B87ECD3C341851476581D789806_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_510C4B87ECD3C341851476581D789806" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementProductAgreementMember_510C4B87ECD3C341851476581D789806_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementProductAgreementMember_510C4B87ECD3C341851476581D789806" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Product [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollaborativeArrangementProductAgreementMember" xlink:label="loc_us-gaap_CollaborativeArrangementProductAgreementMember_510C4B87ECD3C341851476581D789806" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E8F6E49FEC6B8EAF99576581D7816C6_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E8F6E49FEC6B8EAF99576581D7816C6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E8F6E49FEC6B8EAF99576581D7816C6_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E8F6E49FEC6B8EAF99576581D7816C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E8F6E49FEC6B8EAF99576581D7816C6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_4D2A2E45D80D32635A6776581D79CCAC_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived_4D2A2E45D80D32635A6776581D79CCAC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> License revenue, initial payment </link:label>
<link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_4D2A2E45D80D32635A6776581D79CCAC_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived_4D2A2E45D80D32635A6776581D79CCAC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from License Fees Received </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_4D2A2E45D80D32635A6776581D79CCAC" xlink:type="locator"/>
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<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment to be received </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4_label_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:label id="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement. Maximum Milestone Payments </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeArrangement.MaximumMilestonePayments" xlink:label="loc_opk_CollaborativeArrangement.MaximumMilestonePayments_5183A1E0475C4FE976A176581D7930F4" xlink:type="locator"/>
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<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C_terseLabel_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Royalty revenue, obligation period after first product sale </link:label>
<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C_label_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Royalty Revenue, Obligation Period </link:label>
<link:label id="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C_documentation_en-US" xlink:label="lab_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Royalty Revenue, Obligation Period </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_RoyaltyRevenueObligationPeriod" xlink:label="loc_opk_RoyaltyRevenueObligationPeriod_2D6BC9A7760D7ECCB5A376581D795D7C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_0874C0434CB01C0E140976581D799D01_terseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_0874C0434CB01C0E140976581D799D01" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone revenue recognized </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_0874C0434CB01C0E140976581D799D01_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_0874C0434CB01C0E140976581D799D01" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Milestone Method, Revenue Recognized </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_0874C0434CB01C0E140976581D799D01" xlink:type="locator"/>
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<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-refundable and non-creditable upfront payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8_label_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Upfront Payment </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeArrangementUpfrontPayment" xlink:label="loc_opk_CollaborativeArrangementUpfrontPayment_11F86D48397D1A3B965276581D799BB8" xlink:type="locator"/>
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<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39_verboseLabel_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from transfer of intellectual property and other </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39_label_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:label id="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39_documentation_en-US" xlink:label="lab_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue From Transfer Of Intellectual Property </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_RevenueFromTransferOfIntellectualProperty" xlink:label="loc_opk_RevenueFromTransferOfIntellectualProperty_2361CF70B94BC72E8A8B76581D799D39" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6_label_en-US" xlink:label="lab_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6" xlink:to="lab_us-gaap_DeferredRevenue_A0E5831B5716FDB6797B76581D7993A6" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Each milestone payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeArrangementMilestonePayment" xlink:label="loc_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:to="lab_opk_CollaborativeArrangementMilestonePayment_773CB909D45B632E69B476581D790C23" xlink:type="arc"/>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155_terseLabel_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Upfront payment under license agreements </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155_label_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:label id="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155_documentation_en-US" xlink:label="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> License and Collaboration Agreements Proceeds as Up Front Payment </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment" xlink:label="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:to="lab_opk_LicenseandCollaborationAgreementsProceedsasUpFrontPayment_09B477FF7C2C7BA8765976581D79B155" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44_terseLabel_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44_label_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:label id="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44_documentation_en-US" xlink:label="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Milestone Payment Received </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeArrangementMilestonePaymentReceived" xlink:label="loc_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:to="lab_opk_CollaborativeArrangementMilestonePaymentReceived_0D8AE6E03BDB3FEA0CBC76581D79CE44" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional milestone payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150_label_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:label id="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Additional Milestone Payment </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeAgreementAdditionalMilestonePayment" xlink:label="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:to="lab_opk_CollaborativeAgreementAdditionalMilestonePayment_341BA2A1F7099DE4CB5176581D793150" xlink:type="arc"/>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F_terseLabel_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Period from first commercial sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F_label_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:label id="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F_documentation_en-US" xlink:label="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Collaborative Agreement, Period from First Commercial Sale </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CollaborativeAgreementPeriodfromFirstCommercialSale" xlink:label="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:to="lab_opk_CollaborativeAgreementPeriodfromFirstCommercialSale_C0632398BCF8EA2CCDE176581D796E8F" xlink:type="arc"/>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage, equity method </link:label>
<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_6B0A11F1DA6FE534A57876581D7966A0" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22_verboseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Maximum milestone payments to be received </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Estimated Milestone Payments To Be Received </link:label>
<link:label id="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estimated milestone payment to be received. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived" xlink:label="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:to="lab_opk_EquityMethodInvestmentEstimatedMilestonePaymentsToBeReceived_204EDE59A6A7E31CB64A76581D799E22" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfGoodwillTable" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D" xlink:to="lab_us-gaap_ScheduleOfGoodwillTable_F634F50DD771A9ED388876581F2BAB6D" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_6E3731483617FAE8966C76581F2BB0F0_terseLabel_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_6E3731483617FAE8966C76581F2BB0F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_6E3731483617FAE8966C76581F2BB0F0_label_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis_6E3731483617FAE8966C76581F2BB0F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_6E3731483617FAE8966C76581F2BB0F0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SegmentDomain_D164F67FBEBB8F9AAA2876581F2C717C_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentDomain_D164F67FBEBB8F9AAA2876581F2C717C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentDomain_D164F67FBEBB8F9AAA2876581F2C717C_label_en-US" xlink:label="lab_us-gaap_SegmentDomain_D164F67FBEBB8F9AAA2876581F2C717C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segments [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_D164F67FBEBB8F9AAA2876581F2C717C" xlink:type="locator"/>
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<link:label id="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A_terseLabel_en-US" xlink:label="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pharmaceutical </link:label>
<link:label id="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A_label_en-US" xlink:label="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:label id="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A_documentation_en-US" xlink:label="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Pharmaceutical [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_PharmaceuticalMember" xlink:label="loc_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:to="lab_opk_PharmaceuticalMember_EB4CC1E186F889E9707976581F2C102A" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066_terseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:label id="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066_label_en-US" xlink:label="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Diagnostics [Member] </link:label>
<link:label id="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066_documentation_en-US" xlink:label="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Diagnostics. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:to="lab_opk_DiagnosticsMember_BF30ECA96F8C66F04E0076581F2C7066" xlink:type="arc"/>
<link:label id="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3_terseLabel_en-US" xlink:label="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CURNA </link:label>
<link:label id="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3_label_en-US" xlink:label="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:label id="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3_documentation_en-US" xlink:label="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> CURNA [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CURNAMember" xlink:label="loc_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:to="lab_opk_CURNAMember_8B0C41B7777B2DCB49C876581F2C75E3" xlink:type="arc"/>
<link:label id="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571_verboseLabel_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> EirGen </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571_label_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:label id="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571_documentation_en-US" xlink:label="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> EirGen Pharma Limited [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_EirGenPharmaLimitedMember" xlink:label="loc_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:to="lab_opk_EirGenPharmaLimitedMember_20E6155E66960A6C709D76581F2C9571" xlink:type="arc"/>
<link:label id="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9_terseLabel_en-US" xlink:label="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> FineTech </link:label>
<link:label id="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9_label_en-US" xlink:label="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> FineTech [Member] </link:label>
<link:label id="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9_documentation_en-US" xlink:label="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> FineTech. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_FineTechMember" xlink:label="loc_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:to="lab_opk_FineTechMember_850A74BAB217D704648D76581F2C02F9" xlink:type="arc"/>
<link:label id="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93_terseLabel_en-US" xlink:label="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Chile </link:label>
<link:label id="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93_label_en-US" xlink:label="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Chile [Member] </link:label>
<link:label id="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93_documentation_en-US" xlink:label="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Opko Chile. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OpkoChileMember" xlink:label="loc_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:to="lab_opk_OpkoChileMember_421B067DF83B4B28C1A676581F2C1A93" xlink:type="arc"/>
<link:label id="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59_terseLabel_en-US" xlink:label="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Biologics </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59_label_en-US" xlink:label="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:label id="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59_documentation_en-US" xlink:label="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Biologics [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OPKOBiologicsMember" xlink:label="loc_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:to="lab_opk_OPKOBiologicsMember_B29E8F9B0A068C1B970F76581F2C3B59" xlink:type="arc"/>
<link:label id="lab_opk_OPKOHealthEuropeMember_9A4FDECB3DA33247C31E76581F2CDB2B_terseLabel_en-US" xlink:label="lab_opk_OPKOHealthEuropeMember_9A4FDECB3DA33247C31E76581F2CDB2B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Health Europe </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OPKOHealthEuropeMember" xlink:label="loc_opk_OPKOHealthEuropeMember_9A4FDECB3DA33247C31E76581F2CDB2B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKOHealthEuropeMember_9A4FDECB3DA33247C31E76581F2CDB2B" xlink:to="lab_opk_OPKOHealthEuropeMember_9A4FDECB3DA33247C31E76581F2CDB2B" xlink:type="arc"/>
<link:label id="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A_terseLabel_en-US" xlink:label="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Renal </link:label>
<link:label id="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A_label_en-US" xlink:label="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:label id="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A_documentation_en-US" xlink:label="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Rental [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OPKORentalMember" xlink:label="loc_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:to="lab_opk_OPKORentalMember_310EC7996D5968F36E2976581F2C008A" xlink:type="arc"/>
<link:label id="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6_terseLabel_en-US" xlink:label="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics </link:label>
<link:label id="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6_label_en-US" xlink:label="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:label id="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6_documentation_en-US" xlink:label="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Claros [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ClarosMember" xlink:label="loc_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:to="lab_opk_ClarosMember_8838F4918208B395FA7376581F2CA6D6" xlink:type="arc"/>
<link:label id="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D_verboseLabel_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> OPKO Lab </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D_label_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Opko Diagnostics [Member] </link:label>
<link:label id="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D_documentation_en-US" xlink:label="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> OPKO Diagnostics. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OpkoDiagnosticsMember" xlink:label="loc_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:to="lab_opk_OpkoDiagnosticsMember_59C49F6051169B33C04476581F2DBD2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:label id="lab_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0_label_en-US" xlink:label="lab_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillLineItems" xlink:label="loc_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0" xlink:to="lab_us-gaap_GoodwillLineItems_24A76B2FE3C3160D03D776581F2D45E0" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillRollForward_7C561A1F99F16A27825F76581F2DFE9B_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_7C561A1F99F16A27825F76581F2DFE9B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:label id="lab_us-gaap_GoodwillRollForward_7C561A1F99F16A27825F76581F2DFE9B_label_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_7C561A1F99F16A27825F76581F2DFE9B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillRollForward" xlink:label="loc_us-gaap_GoodwillRollForward_7C561A1F99F16A27825F76581F2DFE9B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Goodwill_F0FE43DD8F6B3BD98E2276581F2D089E_periodStartLabel_en-US" xlink:label="lab_us-gaap_Goodwill_F0FE43DD8F6B3BD98E2276581F2D089E" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_F0FE43DD8F6B3BD98E2276581F2D089E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_CCA267E1022010E041F876581F2D4043_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_CCA267E1022010E041F876581F2D4043" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign exchange and other </link:label>
<link:label id="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_CCA267E1022010E041F876581F2D4043_label_en-US" xlink:label="lab_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_CCA267E1022010E041F876581F2D4043" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Foreign Currency Translation Gain (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_CCA267E1022010E041F876581F2D4043" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Goodwill_790D0E51725D081D33A576581F2D2A01_periodEndLabel_en-US" xlink:label="lab_us-gaap_Goodwill_790D0E51725D081D33A576581F2D2A01" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_790D0E51725D081D33A576581F2D2A01" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_790D0E51725D081D33A576581F2D2A01" xlink:to="lab_us-gaap_Goodwill_790D0E51725D081D33A576581F2D2A01" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_E19C3989029625A3255976581DE5F284_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_E19C3989029625A3255976581DE5F284" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Investments Classified as Available for Sale and Carried at Fair Value </link:label>
<link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_E19C3989029625A3255976581DE5F284_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_E19C3989029625A3255976581DE5F284" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Available-for-sale Securities Reconciliation [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_E19C3989029625A3255976581DE5F284" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B6D42B3DFC976B114BBB76581DE56E89_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B6D42B3DFC976B114BBB76581DE56E89" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis </link:label>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B6D42B3DFC976B114BBB76581DE56E89_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_B6D42B3DFC976B114BBB76581DE56E89" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C23B2B727880F9B9769376581DE5977C_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C23B2B727880F9B9769376581DE5977C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> The Carrying Amount and Estimated Fair Value of Our Long-term Debt </link:label>
<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C23B2B727880F9B9769376581DE5977C_label_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTextBlock_C23B2B727880F9B9769376581DE5977C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table Text Block] </link:label>
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<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28_verboseLabel_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Reconciliation of the Beginning and Ending Balances of Level 3 Assets and Liabilities </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28_label_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets And Liabilities Measured On Recurring Basis, Unobservable Input Reconciliation [Table Text Block] </link:label>
<link:label id="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28_documentation_en-US" xlink:label="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Reconciles beginning and ending balances of level three assets and liabilities. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:label="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:to="lab_opk_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_D38471DD65FFB7E7692876581DE5BB28" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_333149C98F10371182C1BF23BCD1BED0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_333149C98F10371182C1BF23BCD1BED0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Earnings (Loss) Per Share </link:label>
<link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_333149C98F10371182C1BF23BCD1BED0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_333149C98F10371182C1BF23BCD1BED0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_333149C98F10371182C1BF23BCD1BED0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EarningsPerShareTextBlock_88FE1C9692A11BAD686B76581F7DB6CD_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_88FE1C9692A11BAD686B76581F7DB6CD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Earnings (Loss) Per Share </link:label>
<link:label id="lab_us-gaap_EarningsPerShareTextBlock_88FE1C9692A11BAD686B76581F7DB6CD_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareTextBlock_88FE1C9692A11BAD686B76581F7DB6CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_88FE1C9692A11BAD686B76581F7DB6CD" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccountingPoliciesAbstract_D62E0EE7C6FB140D889A76581F922B5F_label_en-US" xlink:label="lab_us-gaap_AccountingPoliciesAbstract_D62E0EE7C6FB140D889A76581F922B5F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_D62E0EE7C6FB140D889A76581F922B5F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616_verboseLabel_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Basis of presentation </link:label>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616_label_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Basis of Accounting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616" xlink:to="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_8F88181578BCF9FBA81E76581F932616" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Principles of consolidation </link:label>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3_label_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3" xlink:to="lab_us-gaap_ConsolidationPolicyTextBlock_A22B886D8476CB9C919576581F93D4B3" xlink:type="arc"/>
<link:label id="lab_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594_verboseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Use of estimates </link:label>
<link:label id="lab_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Use of Estimates, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594" xlink:to="lab_us-gaap_UseOfEstimates_11E4F35615B40CEA847F76581F930594" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E" xlink:to="lab_us-gaap_CashAndCashEquivalentsPolicyTextBlock_E5464052740AE2A119BE76581F93542E" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_44191FF0DBE8B189825E76581F930B2B_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_44191FF0DBE8B189825E76581F930B2B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories </link:label>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_44191FF0DBE8B189825E76581F930B2B_label_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_44191FF0DBE8B189825E76581F930B2B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_44191FF0DBE8B189825E76581F930B2B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_A4561EB8F45F46219E2876581F9385D4_verboseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_A4561EB8F45F46219E2876581F9385D4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill and intangible assets </link:label>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_A4561EB8F45F46219E2876581F9385D4_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_A4561EB8F45F46219E2876581F9385D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_A4561EB8F45F46219E2876581F9385D4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_ABC5D372E809DA00D76C76581F93FF99_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_ABC5D372E809DA00D76C76581F93FF99" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Fair value measurements </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_ABC5D372E809DA00D76C76581F93FF99_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_ABC5D372E809DA00D76C76581F93FF99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_ABC5D372E809DA00D76C76581F93FF99" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessCombinationsPolicy_AD79EC2A04618040D70776581F9304DB_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_AD79EC2A04618040D70776581F9304DB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_AD79EC2A04618040D70776581F9304DB_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_AD79EC2A04618040D70776581F9304DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_AD79EC2A04618040D70776581F9304DB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_34226F44D00934E9B7AA76581F939CF1_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_34226F44D00934E9B7AA76581F939CF1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative financial instruments </link:label>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_34226F44D00934E9B7AA76581F939CF1_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_34226F44D00934E9B7AA76581F939CF1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Policy [Policy Text Block] </link:label>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_1B0D6791833A2DB6D66A76581F93785E_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_1B0D6791833A2DB6D66A76581F93785E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_1B0D6791833A2DB6D66A76581F93785E_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_1B0D6791833A2DB6D66A76581F93785E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Policy [Policy Text Block] </link:label>
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<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Impairment of long-lived assets </link:label>
<link:label id="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F_label_en-US" xlink:label="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:label="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F" xlink:to="lab_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_55BAFBF81AFE8B18610576581F93E10F" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_FE1D6F87A53810A05B9276581F93DB8C_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_FE1D6F87A53810A05B9276581F93DB8C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes </link:label>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_FE1D6F87A53810A05B9276581F93DB8C_label_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_FE1D6F87A53810A05B9276581F93DB8C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_FE1D6F87A53810A05B9276581F93DB8C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_E1AA313CFFC3B46BC79776581F93C924_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_E1AA313CFFC3B46BC79776581F93C924" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue recognition </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_E1AA313CFFC3B46BC79776581F93C924_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_E1AA313CFFC3B46BC79776581F93C924" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_E1AA313CFFC3B46BC79776581F93C924" xlink:type="locator"/>
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<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85_verboseLabel_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Concentration of credit risk and allowance for doubtful accounts </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85_label_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts [Policy Text Block] </link:label>
<link:label id="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85_documentation_en-US" xlink:label="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Allowance for doubtful accounts. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:label="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:to="lab_opk_AllowanceForDoubtfulAccountsPolicyTextBlock_BA85D63C7DA153C59E7576581F93EC85" xlink:type="arc"/>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F_verboseLabel_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation </link:label>
<link:label id="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F_label_en-US" xlink:label="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Compensation Related Costs, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CompensationRelatedCostsPolicyTextBlock" xlink:label="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F" xlink:to="lab_us-gaap_CompensationRelatedCostsPolicyTextBlock_D2985E2E1854FCF89E5E76581F93D98F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Research and development expenses </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_5E6F8983F0536CC7DDC476581F9312CA" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19_verboseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Segment reporting </link:label>
<link:label id="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19_label_en-US" xlink:label="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19" xlink:to="lab_us-gaap_SegmentReportingPolicyPolicyTextBlock_BEDC16B0D1A55A221EB476581F932A19" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Variable interest entities </link:label>
<link:label id="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6_label_en-US" xlink:label="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Variable Interest Entity, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationVariableInterestEntityPolicy" xlink:label="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6" xlink:to="lab_us-gaap_ConsolidationVariableInterestEntityPolicy_9581A86202F6E244311D76581F94C7E6" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853_label_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_B2FDF660CA8DD3C1DA1876581F94C853" xlink:type="arc"/>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_78CE5186EB219D0B530A76581F944ADB_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_78CE5186EB219D0B530A76581F944ADB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Recent accounting pronouncements </link:label>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_78CE5186EB219D0B530A76581F944ADB_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_78CE5186EB219D0B530A76581F944ADB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_78CE5186EB219D0B530A76581F944ADB" xlink:type="locator"/>
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<link:label id="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A_terseLabel_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of sales employees </link:label>
<link:label id="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A_label_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Sales Employees </link:label>
<link:label id="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A_documentation_en-US" xlink:label="lab_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Number of Sales Employees </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_NumberofSalesEmployees" xlink:label="loc_opk_NumberofSalesEmployees_5DA0FB7F1677AA57D0F876581F99434A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_79699898DF842B8C42FD76581F996AAE_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_79699898DF842B8C42FD76581F996AAE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock received (in shares) </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_79699898DF842B8C42FD76581F996AAE_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_79699898DF842B8C42FD76581F996AAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Equity Interest Issued or Issuable, Number of Shares </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_79699898DF842B8C42FD76581F996AAE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_531AE995892E55E5741276581F99E27C_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_531AE995892E55E5741276581F99E27C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consideration transferred </link:label>
<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_531AE995892E55E5741276581F99E27C_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_531AE995892E55E5741276581F99E27C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_531AE995892E55E5741276581F99E27C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SharePrice_E7815D665849DEDBC25F76581F9901DB_terseLabel_en-US" xlink:label="lab_us-gaap_SharePrice_E7815D665849DEDBC25F76581F9901DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock price per share (in dollars per share) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_E7815D665849DEDBC25F76581F9901DB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeStatementAbstract_62179DC40E59385A197B84FBF0564DF9_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract_62179DC40E59385A197B84FBF0564DF9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_62179DC40E59385A197B84FBF0564DF9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenues: </link:label>
<link:label id="lab_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueNetAbstract" xlink:label="loc_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003" xlink:to="lab_us-gaap_SalesRevenueNetAbstract_EEAFBDD12F2B3E4EB7ED84FBF056F003" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442_label_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Services, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442" xlink:to="lab_us-gaap_SalesRevenueServicesNet_F7BC2CACF9C888CE6D6784FBF056D442" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48_verboseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from products </link:label>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48_label_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Goods, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48" xlink:to="lab_us-gaap_SalesRevenueGoodsNet_EDA7385D2B0DFA932B2784FBF0568E48" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D_totalLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:label id="lab_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D" xlink:to="lab_us-gaap_SalesRevenueNet_DDB820CA370277C0CCB584FBF057829D" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1_verboseLabel_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Costs and expenses: </link:label>
<link:label id="lab_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1_label_en-US" xlink:label="lab_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpensesAbstract" xlink:label="loc_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1" xlink:to="lab_us-gaap_OperatingExpensesAbstract_32A1961AD4B6DDFD993284FBF0572BC1" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of service revenue </link:label>
<link:label id="lab_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982_label_en-US" xlink:label="lab_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CostOfServices" xlink:label="loc_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982" xlink:to="lab_us-gaap_CostOfServices_7034CADD0DFD799ECE3684FBF0570982" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of product revenue </link:label>
<link:label id="lab_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B_label_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Goods Sold </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B" xlink:to="lab_us-gaap_CostOfGoodsSold_68AF98DFF8B80DD8446184FBF057468B" xlink:type="arc"/>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11_verboseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Selling, general and administrative </link:label>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11_label_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11" xlink:to="lab_us-gaap_SellingGeneralAndAdministrativeExpense_ABBD46EADBD053013E4884FBF0577E11" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2_verboseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Research and development </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpense_09B6C9EF0E0627BB700184FBF0572EF2" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_34704FC6CC28FED5A1D684FBF05761DE" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_3A1E29266EA7410C429084FBF057B451_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_3A1E29266EA7410C429084FBF057B451" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of intangible assets </link:label>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_3A1E29266EA7410C429084FBF057B451_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_3A1E29266EA7410C429084FBF057B451" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Intangible Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_3A1E29266EA7410C429084FBF057B451" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total costs and expenses </link:label>
<link:label id="lab_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED_label_en-US" xlink:label="lab_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED" xlink:to="lab_us-gaap_OperatingExpenses_16E991C3B11AD4953B5884FBF0575EED" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_A67AEF0B5D1F3E0CE71084FBF057974A_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_A67AEF0B5D1F3E0CE71084FBF057974A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Operating income (loss) </link:label>
<link:label id="lab_us-gaap_OperatingIncomeLoss_A67AEF0B5D1F3E0CE71084FBF057974A_label_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_A67AEF0B5D1F3E0CE71084FBF057974A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_A67AEF0B5D1F3E0CE71084FBF057974A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_833000338E420617F6BA84FBF0577F55_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_833000338E420617F6BA84FBF0577F55" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net: </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_833000338E420617F6BA84FBF0577F55_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_833000338E420617F6BA84FBF0577F55" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_833000338E420617F6BA84FBF0577F55" xlink:type="locator"/>
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<link:label id="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7_verboseLabel_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest income </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7_label_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:label id="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7_documentation_en-US" xlink:label="lab_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Income, Nonoperating </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_InterestIncomeNonoperating" xlink:label="loc_opk_InterestIncomeNonoperating_E2DB37A5F28CDA11135484FBF0578CC7" xlink:type="locator"/>
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<link:label id="lab_opk_InterestExpenseNonoperating_BF12576E0009700BF1E584FBF0570294_negatedLabel_en-US" xlink:label="lab_opk_InterestExpenseNonoperating_BF12576E0009700BF1E584FBF0570294" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Interest expense </link:label>
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<link:label id="lab_us-gaap_NonoperatingIncomeExpense_03ACC262FEC4F19EE7DF84FBF0579BA8_totalLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_03ACC262FEC4F19EE7DF84FBF0579BA8" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Other income and (expense), net </link:label>
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<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_24BDCAF830BDDDD6734E84FBF058D291_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_24BDCAF830BDDDD6734E84FBF058D291" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Loss from investments in investees </link:label>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_24BDCAF830BDDDD6734E84FBF058D291_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_24BDCAF830BDDDD6734E84FBF058D291" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Equity Method Investments </link:label>
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<link:label id="lab_us-gaap_ProfitLoss_2C9FE5BBD2B3A8BA83DB84FBF05864A0_totalLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_2C9FE5BBD2B3A8BA83DB84FBF05864A0" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:label id="lab_us-gaap_ProfitLoss_2C9FE5BBD2B3A8BA83DB84FBF05864A0_label_en-US" xlink:label="lab_us-gaap_ProfitLoss_2C9FE5BBD2B3A8BA83DB84FBF05864A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Income (Loss), Including Portion Attributable to Noncontrolling Interest </link:label>
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<link:label id="lab_us-gaap_EarningsPerShareAbstract_9F79196C28BF260AD59784FBF0587504_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareAbstract_9F79196C28BF260AD59784FBF0587504" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings (loss) per share: </link:label>
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<link:label id="lab_us-gaap_EarningsPerShareBasic_0482C1D82840B443188984FBF058E1DE_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_0482C1D82840B443188984FBF058E1DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings per share, basic (in dollars per share) </link:label>
<link:label id="lab_us-gaap_EarningsPerShareBasic_0482C1D82840B443188984FBF058E1DE_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_0482C1D82840B443188984FBF058E1DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share, Basic </link:label>
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<link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_0192DA992C0FC80BDC79B5A678AFCC72_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract_0192DA992C0FC80BDC79B5A678AFCC72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Financial Position [Abstract] </link:label>
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<link:label id="lab_us-gaap_AssetsAbstract_BBABD910D9A21831AFC0B5A678AFA25C_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_BBABD910D9A21831AFC0B5A678AFA25C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ASSETS </link:label>
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<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_8A8B403682CD929424FFB5A678B0DA22_verboseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_8A8B403682CD929424FFB5A678B0DA22" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other current assets and prepaid expenses </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_8A8B403682CD929424FFB5A678B0DA22_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_8A8B403682CD929424FFB5A678B0DA22" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_8A8B403682CD929424FFB5A678B0DA22" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current assets </link:label>
<link:label id="lab_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44_label_en-US" xlink:label="lab_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44" xlink:to="lab_us-gaap_AssetsCurrent_211EAEC761AC6E7DE3DEB5A678B01D44" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_DA0E38B38853E39EE746B5A678B0EAB4_verboseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_DA0E38B38853E39EE746B5A678B0EAB4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, net </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_DA0E38B38853E39EE746B5A678B0EAB4_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_DA0E38B38853E39EE746B5A678B0EAB4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_DA0E38B38853E39EE746B5A678B0EAB4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet_7E708949E1C3612070A7B5A678B05719" xlink:type="arc"/>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243_verboseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> In-process research and development </link:label>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Indefinite-Lived Intangible Assets (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_C3EFAEE9B0CD45E98D0FB5A678B0A243" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermInvestments_0C591DCFBD29C04E6B6AB5A678B05174_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_0C591DCFBD29C04E6B6AB5A678B05174" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_0C591DCFBD29C04E6B6AB5A678B05174" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermInvestments_0C591DCFBD29C04E6B6AB5A678B05174" xlink:to="lab_us-gaap_LongTermInvestments_0C591DCFBD29C04E6B6AB5A678B05174" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627_label_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627" xlink:to="lab_us-gaap_OtherAssetsNoncurrent_2C18F2A57E058CF748D8B5A678B0F627" xlink:type="arc"/>
<link:label id="lab_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6_totalLabel_en-US" xlink:label="lab_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6_label_en-US" xlink:label="lab_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6" xlink:to="lab_us-gaap_Assets_FA1E194BD5C818E65EA1B5A678B0A7A6" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> LIABILITIES AND EQUITY </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_CFFC7580851D5646F6E1B5A678B14679" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7" xlink:to="lab_us-gaap_LiabilitiesCurrentAbstract_D8716660DD1446244694B5A678B19EA7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsPayableCurrent_5EDD1D440222DEBFDC31B5A678B1FC51_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_5EDD1D440222DEBFDC31B5A678B1FC51" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_AccountsPayableCurrent_5EDD1D440222DEBFDC31B5A678B1FC51_label_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent_5EDD1D440222DEBFDC31B5A678B1FC51" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Payable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_5EDD1D440222DEBFDC31B5A678B1FC51" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_3482815210BCBA82A9E3B5A678B10509_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_3482815210BCBA82A9E3B5A678B10509" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_3482815210BCBA82A9E3B5A678B10509_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_3482815210BCBA82A9E3B5A678B10509" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_3482815210BCBA82A9E3B5A678B10509" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebtCurrent_1850D5F42427A042CDD6B5A678B1947E_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_1850D5F42427A042CDD6B5A678B1947E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Current portion of lines of credit and notes payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_1850D5F42427A042CDD6B5A678B1947E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B" xlink:to="lab_us-gaap_LiabilitiesCurrent_9CDC7A15098A44F73A57B5A678B18D0B" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_0E04EAA62F7D3AF40D3CB5A678B1B4AD_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_0E04EAA62F7D3AF40D3CB5A678B1B4AD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes and estimated fair value of embedded derivatives, net of discount </link:label>
<link:label id="lab_us-gaap_ConvertibleLongTermNotesPayable_0E04EAA62F7D3AF40D3CB5A678B1B4AD_label_en-US" xlink:label="lab_us-gaap_ConvertibleLongTermNotesPayable_0E04EAA62F7D3AF40D3CB5A678B1B4AD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Convertible Notes Payable, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_0E04EAA62F7D3AF40D3CB5A678B1B4AD" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_B5E10599BCC4721696A1B5A678B131CF_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_B5E10599BCC4721696A1B5A678B131CF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred tax liabilities, net </link:label>
<link:label id="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_B5E10599BCC4721696A1B5A678B131CF_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilitiesNet_B5E10599BCC4721696A1B5A678B131CF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Income Tax Liabilities, Net </link:label>
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<link:label id="lab_us-gaap_SignificantAccountingPoliciesTextBlock_7BF939B86ABFED534C8176581F96F641_label_en-US" xlink:label="lab_us-gaap_SignificantAccountingPoliciesTextBlock_7BF939B86ABFED534C8176581F96F641" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Significant Accounting Policies [Text Block] </link:label>
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<link:label id="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_1BB87866D7C8A5C62B6576581EEE2688_terseLabel_en-US" xlink:label="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_1BB87866D7C8A5C62B6576581EEE2688" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payment for promissory note </link:label>
<link:label id="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_1BB87866D7C8A5C62B6576581EEE2688_label_en-US" xlink:label="lab_us-gaap_OriginationOfNotesReceivableFromRelatedParties_1BB87866D7C8A5C62B6576581EEE2688" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Origination of Notes Receivable from Related Parties </link:label>
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<link:label id="lab_us-gaap_CommonStockSharesIssued_82F849F3B34865148C5E76581EEFADB4_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_82F849F3B34865148C5E76581EEFADB4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock (in shares) </link:label>
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<link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_D77500F0AD97C1538C5076581DA935DC_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable_D77500F0AD97C1538C5076581DA935DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, by Balance Sheet Grouping [Table] </link:label>
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<link:label id="lab_us-gaap_FairValueInputsLevel3Member_75E0934180AC122D085376581DAAA738_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member_75E0934180AC122D085376581DAAA738" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Level 3 </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_75E0934180AC122D085376581DAAA738" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_67BB63DC92834F47626C76581DAAE3C4_verboseLabel_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_67BB63DC92834F47626C76581DAAE3C4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes </link:label>
<link:label id="lab_us-gaap_NotesPayableFairValueDisclosure_67BB63DC92834F47626C76581DAAE3C4_label_en-US" xlink:label="lab_us-gaap_NotesPayableFairValueDisclosure_67BB63DC92834F47626C76581DAAE3C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Notes Payable, Fair Value Disclosure </link:label>
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<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_C3448D0A1646AC72FDB776581DEC9143_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_C3448D0A1646AC72FDB776581DEC9143" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> FAIR VALUE MEASUREMENTS </link:label>
<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_C3448D0A1646AC72FDB776581DEC9143_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_C3448D0A1646AC72FDB776581DEC9143" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Text Block] </link:label>
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<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_E4D212EDD53498A1444676581D984235_terseLabel_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_E4D212EDD53498A1444676581D984235" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_E4D212EDD53498A1444676581D984235_label_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_E4D212EDD53498A1444676581D984235" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_E4D212EDD53498A1444676581D984235" xlink:type="locator"/>
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<link:label id="lab_us-gaap_HedgingDesignationAxis_BCB64CAEE0F8765620E976581D9864E0_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_BCB64CAEE0F8765620E976581D9864E0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationAxis_BCB64CAEE0F8765620E976581D9864E0_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_BCB64CAEE0F8765620E976581D9864E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_BCB64CAEE0F8765620E976581D9864E0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_HedgingDesignationDomain_1C7CC26AE3C5ABFC1A9576581D99D30C_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_1C7CC26AE3C5ABFC1A9576581D99D30C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationDomain_1C7CC26AE3C5ABFC1A9576581D99D30C_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_1C7CC26AE3C5ABFC1A9576581D99D30C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_1C7CC26AE3C5ABFC1A9576581D99D30C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NondesignatedMember_A8D7B9AD5699FF55F81A76581D999874_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember_A8D7B9AD5699FF55F81A76581D999874" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument </link:label>
<link:label id="lab_us-gaap_NondesignatedMember_A8D7B9AD5699FF55F81A76581D999874_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember_A8D7B9AD5699FF55F81A76581D999874" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_A8D7B9AD5699FF55F81A76581D999874" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_E23B5361F4871959F84B76581D9907A4_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_E23B5361F4871959F84B76581D9907A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instrument Risk [Axis] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_E23B5361F4871959F84B76581D9907A4_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis_E23B5361F4871959F84B76581D9907A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_E23B5361F4871959F84B76581D9907A4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeContractTypeDomain_FC81FA2EF61B736555CD76581D993900_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_FC81FA2EF61B736555CD76581D993900" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Contract Type [Domain] </link:label>
<link:label id="lab_us-gaap_DerivativeContractTypeDomain_FC81FA2EF61B736555CD76581D993900_label_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain_FC81FA2EF61B736555CD76581D993900" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Contract [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_FC81FA2EF61B736555CD76581D993900" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415_verboseLabel_en-US" xlink:label="lab_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock options/warrants </link:label>
<link:label id="lab_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415_label_en-US" xlink:label="lab_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Option [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415" xlink:to="lab_us-gaap_StockOptionMember_F8B1F3378F62E559500176581D99C415" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForwardContractsMember_4081EFB4BA3C1940E39F76581D991BC8_terseLabel_en-US" xlink:label="lab_us-gaap_ForwardContractsMember_4081EFB4BA3C1940E39F76581D991BC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Forward contracts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="loc_us-gaap_ForwardContractsMember_4081EFB4BA3C1940E39F76581D991BC8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InvestmentsMember_7AE273660304AD994A5376581D997D99_verboseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsMember_7AE273660304AD994A5376581D997D99" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Investments, net </link:label>
<link:label id="lab_us-gaap_InvestmentsMember_7AE273660304AD994A5376581D997D99_label_en-US" xlink:label="lab_us-gaap_InvestmentsMember_7AE273660304AD994A5376581D997D99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentsMember" xlink:label="loc_us-gaap_InvestmentsMember_7AE273660304AD994A5376581D997D99" xlink:type="locator"/>
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<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_C8B20A20B60F149CC8BC76581D99233F_terseLabel_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_C8B20A20B60F149CC8BC76581D99233F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, net of discount and estimated fair value of embedded derivatives </link:label>
<link:label id="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_C8B20A20B60F149CC8BC76581D99233F_label_en-US" xlink:label="lab_opk_ThreePercentConvertibleSeniorNotesNetofDiscountandEstimatedFairValueofEmbeddedDerivativesMember_C8B20A20B60F149CC8BC76581D99233F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Three Percent Convertible, Senior Notes, Net of Discount and Estimated Fair Value of Embedded Derivatives [Member] </link:label>
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<link:label id="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_02554768EE78016DEB3C76581D99D106_terseLabel_en-US" xlink:label="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_02554768EE78016DEB3C76581D99D106" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized gains on forward contracts are recorded in Other current assets and prepaid expenses. Unrealized (losses) on forward contracts are recorded in Accrued expenses. </link:label>
<link:label id="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_02554768EE78016DEB3C76581D99D106_label_en-US" xlink:label="lab_opk_PrepaidExpensesandOtherCurrentAssetsAccruedExpensesMember_02554768EE78016DEB3C76581D99D106" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expenses and Other Current Assets (Accrued Expenses) [Member] </link:label>
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<link:label id="lab_us-gaap_DerivativesFairValueLineItems_C24E55432866B392F7A876581D99A71E_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_C24E55432866B392F7A876581D99A71E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_C24E55432866B392F7A876581D99A71E_label_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_C24E55432866B392F7A876581D99A71E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_C24E55432866B392F7A876581D99A71E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative asset, fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Asset, Fair Value, Gross Asset </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_E2D6F31D0C47F431079F76581D99AEC2" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative liability, fair value </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Gross Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_BD44DA71BF51F3ED83CC76581D99C243" xlink:type="arc"/>
<link:label id="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF_terseLabel_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF_label_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:label id="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF_documentation_en-US" xlink:label="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Roll Forward] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DebtInstrumentRollForward" xlink:label="loc_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:to="lab_opk_DebtInstrumentRollForward_82CF9A8A6896B4680BD776581E773DDF" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_1B00253690744DE6E3A876581E77F774_periodStartLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_1B00253690744DE6E3A876581E77F774" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_1B00253690744DE6E3A876581E77F774" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_1B00253690744DE6E3A876581E77F774" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_1B00253690744DE6E3A876581E77F774" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533_periodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_F51DB9C23F87E4A7BBA876581E77F533" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US"> Discount, beginning balance </link:label>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Unamortized Discount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_77910C931EFB89F76B9076581E77C541" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6_negatedPeriodStartLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US"> Debt issuance cost, beginning balance </link:label>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6_label_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Issuance Costs, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredFinanceCostsNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6" xlink:to="lab_us-gaap_DeferredFinanceCostsNet_5B3026F4C8EEED5270C676581E78EFA6" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_7C4AF1E5B05CBAAD9B1176581E789932_periodStartLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_7C4AF1E5B05CBAAD9B1176581E789932" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Total, beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_7C4AF1E5B05CBAAD9B1176581E789932" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_7C4AF1E5B05CBAAD9B1176581E789932" xlink:to="lab_us-gaap_LongTermDebt_7C4AF1E5B05CBAAD9B1176581E789932" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt discount </link:label>
<link:label id="lab_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34_label_en-US" xlink:label="lab_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Discount (Premium) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34" xlink:to="lab_us-gaap_AmortizationOfDebtDiscountPremium_67AFA7DD3608E7E82A7D76581E786C34" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt issuance costs </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Issuance Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_C50DA13169DBDBE3F8A276581E78D8EF" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25_totalLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Amortization of debt discount and debt issuance costs </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Issuance Costs and Discounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25" xlink:to="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_82146C6A05EA5232720476581E784F25" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EFD309814D676D7B677C76581E78C3B7_verboseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EFD309814D676D7B677C76581E78C3B7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of embedded derivative </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EFD309814D676D7B677C76581E78C3B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EFD309814D676D7B677C76581E78C3B7" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_EFD309814D676D7B677C76581E78C3B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_B501E1B3334B45B9C97F76581E78698D_periodEndLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_B501E1B3334B45B9C97F76581E78698D" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Embedded conversion option, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_B501E1B3334B45B9C97F76581E78698D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_B501E1B3334B45B9C97F76581E78698D" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_B501E1B3334B45B9C97F76581E78698D" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_8F600F52E718DB4FA57C76581E788107_periodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_8F600F52E718DB4FA57C76581E788107" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> 2033 Senior Notes, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_8F600F52E718DB4FA57C76581E788107" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_8F600F52E718DB4FA57C76581E788107" xlink:to="lab_us-gaap_DebtInstrumentCarryingAmount_8F600F52E718DB4FA57C76581E788107" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_BA1F94E5AC5D048B097676581E784551_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount_BA1F94E5AC5D048B097676581E784551" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US"> Discount, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BA1F94E5AC5D048B097676581E784551" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BA1F94E5AC5D048B097676581E784551" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount_BA1F94E5AC5D048B097676581E784551" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredFinanceCostsNet_4F6B2ECF18F7ED4B482E76581E788497_negatedPeriodEndLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsNet_4F6B2ECF18F7ED4B482E76581E788497" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US"> Debt issuance cost, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredFinanceCostsNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_4F6B2ECF18F7ED4B482E76581E788497" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFinanceCostsNet_4F6B2ECF18F7ED4B482E76581E788497" xlink:to="lab_us-gaap_DeferredFinanceCostsNet_4F6B2ECF18F7ED4B482E76581E788497" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebt_D387D841307E625B3F8E76581E78C214_periodEndLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_D387D841307E625B3F8E76581E78C214" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Total, ending balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_D387D841307E625B3F8E76581E78C214" xlink:type="locator"/>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_C73B2A31B01479E5E53AAED14B30A100" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_C73B2A31B01479E5E53AAED14B30A100" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_C73B2A31B01479E5E53AAED14B30A100" xlink:type="arc"/>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F_terseLabel_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Software </link:label>
<link:label id="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F_label_en-US" xlink:label="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Software and Software Development Costs [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F" xlink:to="lab_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_AE3819FD0B8E372D4785AED14B30277F" xlink:type="arc"/>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0_terseLabel_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Machinery, Medical and Other Equipment </link:label>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0_label_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Machinery and Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0" xlink:to="lab_us-gaap_MachineryAndEquipmentMember_35C2B90845EA3CFF5BF5AED14B30B7D0" xlink:type="arc"/>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7_terseLabel_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures </link:label>
<link:label id="lab_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7_label_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7" xlink:to="lab_us-gaap_FurnitureAndFixturesMember_5FBA7B09C2EDD6EF8374AED14B30CDF7" xlink:type="arc"/>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30_terseLabel_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Buildings and Improvements </link:label>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30_label_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Building and Building Improvements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30" xlink:to="lab_us-gaap_BuildingAndBuildingImprovementsMember_DDFFBD7B192A1879DB4AAED14B31BE30" xlink:type="arc"/>
<link:label id="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536_terseLabel_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft </link:label>
<link:label id="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536_label_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft [Member] </link:label>
<link:label id="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536_documentation_en-US" xlink:label="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Automobiles and Aircraft [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AutomobilesandAircraftMember" xlink:label="loc_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:to="lab_opk_AutomobilesandAircraftMember_F9CF5088414A74B17B9AAED14B310536" xlink:type="arc"/>
<link:label id="lab_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF_terseLabel_en-US" xlink:label="lab_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Government Contracts Concentration Risk </link:label>
<link:label id="lab_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF_label_en-US" xlink:label="lab_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Government Contracts Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GovernmentContractsConcentrationRiskMember" xlink:label="loc_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF" xlink:to="lab_us-gaap_GovernmentContractsConcentrationRiskMember_91C5D52CF69B7CC9738FAED14B3147EF" xlink:type="arc"/>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C_terseLabel_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C_label_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:label id="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C_documentation_en-US" xlink:label="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Summary of Significant Accounting Policies [Line Items] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:to="lab_opk_SummaryOfSignificantAccountingPoliciesLineItems_767B44730DA7CA501139AED14B31141C" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provision for inventory obsolescence </link:label>
<link:label id="lab_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080_label_en-US" xlink:label="lab_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Write-down </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryWriteDown" xlink:label="loc_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080" xlink:to="lab_us-gaap_InventoryWriteDown_1C7DAF5F755E21A41B16AED14B32D080" xlink:type="arc"/>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill, in-process research and development and other intangible assets acquired </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2_label_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:label id="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2_documentation_en-US" xlink:label="lab_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Goodwill and Intangible Assets </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets" xlink:label="loc_opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedGoodwillandIntangibleAssets_F788BA1B963C523BB9D2AED14B3212C2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FB19EBAC5EA897D1B590AED14B328AA2_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FB19EBAC5EA897D1B590AED14B328AA2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, estimated useful lives </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FB19EBAC5EA897D1B590AED14B328AA2_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FB19EBAC5EA897D1B590AED14B328AA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Asset, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_FB19EBAC5EA897D1B590AED14B328AA2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_CF377DBF28DFA5821546AED14B320615_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_CF377DBF28DFA5821546AED14B320615" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_CF377DBF28DFA5821546AED14B320615" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_9A595E4FA68C477DBCB0AED14B32C01E_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_9A595E4FA68C477DBCB0AED14B32C01E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, estimated useful lives </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_9A595E4FA68C477DBCB0AED14B32C01E_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_9A595E4FA68C477DBCB0AED14B32C01E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_9A595E4FA68C477DBCB0AED14B32C01E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Depreciation_F0DEE63E803C2DB15917AED14B3202DB_terseLabel_en-US" xlink:label="lab_us-gaap_Depreciation_F0DEE63E803C2DB15917AED14B3202DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Depreciation expense </link:label>
<link:label id="lab_us-gaap_Depreciation_F0DEE63E803C2DB15917AED14B3202DB_label_en-US" xlink:label="lab_us-gaap_Depreciation_F0DEE63E803C2DB15917AED14B3202DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Depreciation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_F0DEE63E803C2DB15917AED14B3202DB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9AEBD8FC942BAC68AEA9AED14B326519_terseLabel_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9AEBD8FC942BAC68AEA9AED14B326519" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate income tax rate </link:label>
<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9AEBD8FC942BAC68AEA9AED14B326519_label_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9AEBD8FC942BAC68AEA9AED14B326519" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent </link:label>
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<link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61B16768E562F275C77076581F793786_totalLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61B16768E562F275C77076581F793786" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Weighted average common shares outstanding, diluted (in shares) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61B16768E562F275C77076581F793786" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F99ED9F209D1A52367D476581F6801FB_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F99ED9F209D1A52367D476581F6801FB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F99ED9F209D1A52367D476581F6801FB_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F99ED9F209D1A52367D476581F6801FB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfCondensedFinancialStatementsTable" xlink:label="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_F99ED9F209D1A52367D476581F6801FB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CustomerRelationshipsMember_7719E08BF6B9C81A0D0976581F699222_verboseLabel_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_7719E08BF6B9C81A0D0976581F699222" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Customer relationships </link:label>
<link:label id="lab_us-gaap_CustomerRelationshipsMember_7719E08BF6B9C81A0D0976581F699222_label_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember_7719E08BF6B9C81A0D0976581F699222" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Relationships [Member] </link:label>
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<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_03ADDCF4A0FB91E9022376581F693920_terseLabel_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_03ADDCF4A0FB91E9022376581F693920" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Technologies </link:label>
<link:label id="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_03ADDCF4A0FB91E9022376581F693920_label_en-US" xlink:label="lab_us-gaap_TechnologyBasedIntangibleAssetsMember_03ADDCF4A0FB91E9022376581F693920" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Technology-Based Intangible Assets [Member] </link:label>
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<link:label id="lab_us-gaap_TradeNamesMember_77C6C308616908E2A06F76581F69F57A_terseLabel_en-US" xlink:label="lab_us-gaap_TradeNamesMember_77C6C308616908E2A06F76581F69F57A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Trade names </link:label>
<link:label id="lab_us-gaap_TradeNamesMember_77C6C308616908E2A06F76581F69F57A_label_en-US" xlink:label="lab_us-gaap_TradeNamesMember_77C6C308616908E2A06F76581F69F57A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Trade Names [Member] </link:label>
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<link:label id="lab_us-gaap_LicensingAgreementsMember_D81B7B82EEE0C113BB5776581F69EEF6_terseLabel_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_D81B7B82EEE0C113BB5776581F69EEF6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Licenses </link:label>
<link:label id="lab_us-gaap_LicensingAgreementsMember_D81B7B82EEE0C113BB5776581F69EEF6_label_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember_D81B7B82EEE0C113BB5776581F69EEF6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Licensing Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LicensingAgreementsMember" xlink:label="loc_us-gaap_LicensingAgreementsMember_D81B7B82EEE0C113BB5776581F69EEF6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NoncompeteAgreementsMember_1620D28423CC3261EA7576581F690244_terseLabel_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_1620D28423CC3261EA7576581F690244" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Covenants not to compete </link:label>
<link:label id="lab_us-gaap_NoncompeteAgreementsMember_1620D28423CC3261EA7576581F690244_label_en-US" xlink:label="lab_us-gaap_NoncompeteAgreementsMember_1620D28423CC3261EA7576581F690244" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncompete Agreements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoncompeteAgreementsMember" xlink:label="loc_us-gaap_NoncompeteAgreementsMember_1620D28423CC3261EA7576581F690244" xlink:type="locator"/>
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<link:label id="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330_terseLabel_en-US" xlink:label="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product registrations </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330_label_en-US" xlink:label="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:label id="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330_documentation_en-US" xlink:label="lab_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Product Registrations [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ProductRegistrationsMember" xlink:label="loc_opk_ProductRegistrationsMember_7F1D88A3F8AD8025BFDD76581F698330" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_659D2A3F529A1230515A76581F699303_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_659D2A3F529A1230515A76581F699303" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherIntangibleAssetsMember_659D2A3F529A1230515A76581F699303_label_en-US" xlink:label="lab_us-gaap_OtherIntangibleAssetsMember_659D2A3F529A1230515A76581F699303" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Intangible Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_659D2A3F529A1230515A76581F699303" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_89E7C2C3DB6D21B5CAA876581F69563B_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_89E7C2C3DB6D21B5CAA876581F69563B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_89E7C2C3DB6D21B5CAA876581F69563B_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_89E7C2C3DB6D21B5CAA876581F69563B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CondensedFinancialStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_89E7C2C3DB6D21B5CAA876581F69563B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_8BCAE77B6DC11E3BBB5076581F690C64_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_8BCAE77B6DC11E3BBB5076581F690C64" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetAbstract_8BCAE77B6DC11E3BBB5076581F690C64_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetAbstract_8BCAE77B6DC11E3BBB5076581F690C64" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsReceivableNetAbstract" xlink:label="loc_us-gaap_AccountsReceivableNetAbstract_8BCAE77B6DC11E3BBB5076581F690C64" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_8B2AE8303D472DADAFCF76581F694533_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_8B2AE8303D472DADAFCF76581F694533" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable </link:label>
<link:label id="lab_us-gaap_AccountsReceivableGrossCurrent_8B2AE8303D472DADAFCF76581F694533_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableGrossCurrent_8B2AE8303D472DADAFCF76581F694533" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Gross, Current </link:label>
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<link:label id="lab_us-gaap_InventoryNetAbstract_A56A34626B5BCE7B935C76581F6AD1CC_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNetAbstract_A56A34626B5BCE7B935C76581F6AD1CC" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Inventories, net </link:label>
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<link:label id="lab_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A_terseLabel_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consumable supplies </link:label>
<link:label id="lab_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A_label_en-US" xlink:label="lab_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Inventory, Supplies, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherInventorySupplies" xlink:label="loc_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A" xlink:to="lab_us-gaap_OtherInventorySupplies_F7A0E34B69E52A7B06F276581F6A8E2A" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Finished products </link:label>
<link:label id="lab_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09_label_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Finished Goods, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09" xlink:to="lab_us-gaap_InventoryFinishedGoods_76228863AF2E4968E6DC76581F6AAD09" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Work in-process </link:label>
<link:label id="lab_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824_label_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Work in Process, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824" xlink:to="lab_us-gaap_InventoryWorkInProcess_CFEBA3AAADBA8BE9C15876581F6A6824" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Raw materials </link:label>
<link:label id="lab_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA_label_en-US" xlink:label="lab_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Raw Materials, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA" xlink:to="lab_us-gaap_InventoryRawMaterials_6EC7F6FA4F386A64DF2276581F6A79AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E_negatedLabel_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: inventory reserve </link:label>
<link:label id="lab_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E_label_en-US" xlink:label="lab_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory Valuation Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E" xlink:to="lab_us-gaap_InventoryValuationReserves_49EBA6829AA57D6BFBF776581F6A218E" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryNet_B2C255AD8134D8DE981976581F6AEAF5_totalLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_B2C255AD8134D8DE981976581F6AEAF5" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Inventory, net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_B2C255AD8134D8DE981976581F6AEAF5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet_B2C255AD8134D8DE981976581F6AEAF5" xlink:to="lab_us-gaap_InventoryNet_B2C255AD8134D8DE981976581F6AEAF5" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other current assets and prepaid expenses </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_A5B9B77863A06643A7FD76581F6A95BB" xlink:type="arc"/>
<link:label id="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3_terseLabel_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Taxes recoverable </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3_label_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:label id="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3_documentation_en-US" xlink:label="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Taxes Recoverable, Current </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_TaxesRecoverableCurrent" xlink:label="loc_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:to="lab_opk_TaxesRecoverableCurrent_30D5C20EC527A9B3775576581F6A77F3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other receivables </link:label>
<link:label id="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D_label_en-US" xlink:label="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts and Other Receivables, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D" xlink:to="lab_us-gaap_AccountsAndOtherReceivablesNetCurrent_AF5CDFBFFDE8D0F3A3B976581F6AFA2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA_terseLabel_en-US" xlink:label="lab_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid supplies </link:label>
<link:label id="lab_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA_label_en-US" xlink:label="lab_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Supplies </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Supplies" xlink:label="loc_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA" xlink:to="lab_us-gaap_Supplies_3C557150D564591C31C676581F6A62DA" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidInsurance_DB458A0D79BB7CE65A2076581F6A5125_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_DB458A0D79BB7CE65A2076581F6A5125" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid insurance </link:label>
<link:label id="lab_us-gaap_PrepaidInsurance_DB458A0D79BB7CE65A2076581F6A5125_label_en-US" xlink:label="lab_us-gaap_PrepaidInsurance_DB458A0D79BB7CE65A2076581F6A5125" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Insurance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaap_PrepaidInsurance_DB458A0D79BB7CE65A2076581F6A5125" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6_label_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Assets, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6" xlink:to="lab_us-gaap_OtherAssetsCurrent_07C464A0CAE35580206476581F6AEFD6" xlink:type="arc"/>
<link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_E81D2D2B2B9E3BAF2BFB76581F6AD8B6_totalLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_E81D2D2B2B9E3BAF2BFB76581F6AD8B6" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Other current assets and prepaid expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_E81D2D2B2B9E3BAF2BFB76581F6AD8B6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_E81D2D2B2B9E3BAF2BFB76581F6AD8B6" xlink:to="lab_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_E81D2D2B2B9E3BAF2BFB76581F6AD8B6" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_9E6A6B507B96A9D71EC876581F6A1C57_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_9E6A6B507B96A9D71EC876581F6A1C57" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net: </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_9E6A6B507B96A9D71EC876581F6A1C57_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_9E6A6B507B96A9D71EC876581F6A1C57" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Net [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_9E6A6B507B96A9D71EC876581F6A1C57" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_64500444299EA80C1C4176581F6B6B6E_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_64500444299EA80C1C4176581F6B6B6E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_64500444299EA80C1C4176581F6B6B6E_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross_64500444299EA80C1C4176581F6B6B6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_64500444299EA80C1C4176581F6B6B6E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07E2D6C167C42A1331C276581F6B11E8_negatedLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07E2D6C167C42A1331C276581F6B11E8" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: accumulated amortization </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07E2D6C167C42A1331C276581F6B11E8_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07E2D6C167C42A1331C276581F6B11E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Accumulated Amortization </link:label>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_6266B0E9F318649A890A76581F6B3A2E_totalLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet_6266B0E9F318649A890A76581F6B3A2E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
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<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_D1E22C6CE7FEA9AE898576581F6B0D3C_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_D1E22C6CE7FEA9AE898576581F6B0D3C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses: </link:label>
<link:label id="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_D1E22C6CE7FEA9AE898576581F6B0D3C_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrentAbstract_D1E22C6CE7FEA9AE898576581F6B0D3C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Liabilities, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_D1E22C6CE7FEA9AE898576581F6B0D3C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DeferredRevenueCurrent_5C50E48C449A1DFE49D676581F6BB2FB_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueCurrent_5C50E48C449A1DFE49D676581F6BB2FB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Current </link:label>
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<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_FBFF08DD7A5842D3BFEC76581F6B23D8_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_FBFF08DD7A5842D3BFEC76581F6B23D8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Employee benefits </link:label>
<link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_FBFF08DD7A5842D3BFEC76581F6B23D8_label_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_FBFF08DD7A5842D3BFEC76581F6B23D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Employee Benefits, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_FBFF08DD7A5842D3BFEC76581F6B23D8" xlink:type="locator"/>
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<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF_verboseLabel_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Clinical trials </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF_label_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Clinical Trials, Current </link:label>
<link:label id="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF_documentation_en-US" xlink:label="lab_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accrued clinical trials. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AccruedClinicalTrialsCurrent" xlink:label="loc_opk_AccruedClinicalTrialsCurrent_B0D4B68B3D506F7EC9B276581F6B64EF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_9DC40BD14A2357C006BA76581F6B53D1_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_9DC40BD14A2357C006BA76581F6B53D1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Taxes payable </link:label>
<link:label id="lab_us-gaap_AccruedIncomeTaxesCurrent_9DC40BD14A2357C006BA76581F6B53D1_label_en-US" xlink:label="lab_us-gaap_AccruedIncomeTaxesCurrent_9DC40BD14A2357C006BA76581F6B53D1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Income Taxes, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_9DC40BD14A2357C006BA76581F6B53D1" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_CEBA31688106915156C976581F6B7A1D_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_CEBA31688106915156C976581F6B7A1D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_CEBA31688106915156C976581F6B7A1D_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_CEBA31688106915156C976581F6B7A1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration, Liability, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_CEBA31688106915156C976581F6B7A1D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_F380946B91931FBF704276581F6BA586_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_F380946B91931FBF704276581F6BA586" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases short-term </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsCurrent_F380946B91931FBF704276581F6BA586_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsCurrent_F380946B91931FBF704276581F6BA586" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalLeaseObligationsCurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsCurrent_F380946B91931FBF704276581F6BA586" xlink:type="locator"/>
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<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9_terseLabel_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payment </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9_label_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Deferred Acquisition Payments, Net of Discount, Current </link:label>
<link:label id="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9_documentation_en-US" xlink:label="lab_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Deferred acquisition payments net of discount. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent" xlink:label="loc_opk_BusinessCombinationDeferredAcquisitionPaymentsNetofDiscountCurrent_89B9DC424A30D8BB8A3876581F6BF0E9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_FE1967BDC55371C9666076581F6BFDAE_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_FE1967BDC55371C9666076581F6BFDAE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Professional fees </link:label>
<link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_FE1967BDC55371C9666076581F6BFDAE_label_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_FE1967BDC55371C9666076581F6BFDAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Professional Fees, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_FE1967BDC55371C9666076581F6BFDAE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_190D6229C9F13766E03376581F6B3715_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_190D6229C9F13766E03376581F6B3715" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_190D6229C9F13766E03376581F6B3715_label_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_190D6229C9F13766E03376581F6B3715" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Accrued Liabilities, Current </link:label>
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<link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_3DE8F9A4086BA0E3BCEC76581F6B024B_totalLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent_3DE8F9A4086BA0E3BCEC76581F6B024B" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_3DE8F9A4086BA0E3BCEC76581F6B024B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DeferredRevenueNoncurrent_0B93D5A01B135DF51CB176581F6B3133_label_en-US" xlink:label="lab_us-gaap_DeferredRevenueNoncurrent_0B93D5A01B135DF51CB176581F6B3133" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Revenue, Noncurrent </link:label>
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<link:label id="lab_us-gaap_LongTermLineOfCredit_4BEF0691B49EB444B6A976581F6B2A5B_label_en-US" xlink:label="lab_us-gaap_LongTermLineOfCredit_4BEF0691B49EB444B6A976581F6B2A5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit, Noncurrent </link:label>
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<link:label id="lab_us-gaap_CommonStockSharesAuthorized_8D93A4EB8C973DE2CA9276581FB55581_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_8D93A4EB8C973DE2CA9276581FB55581" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares authorized (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesAuthorized_8D93A4EB8C973DE2CA9276581FB55581_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_8D93A4EB8C973DE2CA9276581FB55581" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares Authorized </link:label>
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<link:label id="lab_us-gaap_CommonStockSharesIssued_0343247901430389C08F76581FB55551_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_0343247901430389C08F76581FB55551" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, shares issued (in shares) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_0343247901430389C08F76581FB55551" xlink:type="locator"/>
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<link:label id="lab_us-gaap_TreasuryStockShares_252AC4E8A2FC35CCEE4376581FB52F7E_verboseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_252AC4E8A2FC35CCEE4376581FB52F7E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Treasury stock, shares (in shares) </link:label>
<link:label id="lab_us-gaap_TreasuryStockShares_252AC4E8A2FC35CCEE4376581FB52F7E_label_en-US" xlink:label="lab_us-gaap_TreasuryStockShares_252AC4E8A2FC35CCEE4376581FB52F7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock, Shares </link:label>
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<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_7C172F9B9C7D83A638DC76581D941885_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_7C172F9B9C7D83A638DC76581D941885" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) by Hedging Relationship, by Income Statement Location, by Derivative Instrument Risk [Table] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_7C172F9B9C7D83A638DC76581D941885_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_7C172F9B9C7D83A638DC76581D941885" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_7C172F9B9C7D83A638DC76581D941885" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_732D5DE58618B2390DE076581D94F19F_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_732D5DE58618B2390DE076581D94F19F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_732D5DE58618B2390DE076581D94F19F_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossLineItems_732D5DE58618B2390DE076581D94F19F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instruments, Gain (Loss) [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_732D5DE58618B2390DE076581D94F19F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_3F3140269A0503D5D64D76581D947213_verboseLabel_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_3F3140269A0503D5D64D76581D947213" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Derivative gain (loss) </link:label>
<link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_3F3140269A0503D5D64D76581D947213_label_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet_3F3140269A0503D5D64D76581D947213" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Gain (Loss) on Derivative, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_3F3140269A0503D5D64D76581D947213" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_CBB4276C109F7F850BC576581EFD8D75_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_CBB4276C109F7F850BC576581EFD8D75" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_CBB4276C109F7F850BC576581EFD8D75_label_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_CBB4276C109F7F850BC576581EFD8D75" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Variable Interest Entities [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_CBB4276C109F7F850BC576581EFD8D75" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SeriesAPreferredStockMember_1D249F43FCE00540BE2E76581EFD047A_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_1D249F43FCE00540BE2E76581EFD047A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series A-2 Preferred Stock </link:label>
<link:label id="lab_us-gaap_SeriesAPreferredStockMember_1D249F43FCE00540BE2E76581EFD047A_label_en-US" xlink:label="lab_us-gaap_SeriesAPreferredStockMember_1D249F43FCE00540BE2E76581EFD047A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Series A Preferred Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_1D249F43FCE00540BE2E76581EFD047A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RestrictedStockMember_E8E6715DF13527ECE8DE76581EFDEC6C_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_E8E6715DF13527ECE8DE76581EFDEC6C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restricted Stock </link:label>
<link:label id="lab_us-gaap_RestrictedStockMember_E8E6715DF13527ECE8DE76581EFDEC6C_label_en-US" xlink:label="lab_us-gaap_RestrictedStockMember_E8E6715DF13527ECE8DE76581EFDEC6C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restricted Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_E8E6715DF13527ECE8DE76581EFDEC6C" xlink:type="locator"/>
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<link:label id="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A_terseLabel_en-US" xlink:label="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Zebra </link:label>
<link:label id="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A_label_en-US" xlink:label="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:label id="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A_documentation_en-US" xlink:label="lab_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Zebra [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_ZebraMember" xlink:label="loc_opk_ZebraMember_198492DC6F61E14D764876581EFDB97A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_VariableInterestEntityLineItems_C95BEE185456E8E6F0FB76581EFD94F0_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_C95BEE185456E8E6F0FB76581EFD94F0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityLineItems_C95BEE185456E8E6F0FB76581EFD94F0_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems_C95BEE185456E8E6F0FB76581EFD94F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity [Line Items] </link:label>
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<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_73B8E52BB64A0BA9875076581EFD6464_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_73B8E52BB64A0BA9875076581EFD6464" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment owned (in shares) </link:label>
<link:label id="lab_us-gaap_InvestmentOwnedBalanceShares_73B8E52BB64A0BA9875076581EFD6464_label_en-US" xlink:label="lab_us-gaap_InvestmentOwnedBalanceShares_73B8E52BB64A0BA9875076581EFD6464" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment Owned, Balance, Shares </link:label>
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<link:label id="lab_opk_SharesReceivedAsGift_254BF4B8803BEE58131976581F0246F4_terseLabel_en-US" xlink:label="lab_opk_SharesReceivedAsGift_254BF4B8803BEE58131976581F0246F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares received as a gift (in shares) </link:label>
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<link:label id="lab_opk_MuseumofScienceIncMember_9AB9C9E10FAC0A19481BA9799DA00D82_terseLabel_en-US" xlink:label="lab_opk_MuseumofScienceIncMember_9AB9C9E10FAC0A19481BA9799DA00D82" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Museum of Science, Inc </link:label>
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<link:label id="lab_us-gaap_SeriesGPreferredStockMember_C594E1E6BF92BFE41D58A9799DA07F91_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesGPreferredStockMember_C594E1E6BF92BFE41D58A9799DA07F91" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series G Preferred Stock </link:label>
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<link:label id="lab_opk_SeriesIPreferredStockMember_A855D7D5C4824BE149CEA9799DA114F1_terseLabel_en-US" xlink:label="lab_opk_SeriesIPreferredStockMember_A855D7D5C4824BE149CEA9799DA114F1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Series I Preferred Stock </link:label>
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<link:label id="lab_opk_ReimbursementOfTravelExpenseMember_71F098A5736A9BD19169A9799DA1A4FC_terseLabel_en-US" xlink:label="lab_opk_ReimbursementOfTravelExpenseMember_71F098A5736A9BD19169A9799DA1A4FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement Of Travel Expense </link:label>
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<link:label id="lab_opk_DrFrostandMrPfennigerMember_CAF7FD8C9BE5073683ACA9799DA1F300_terseLabel_en-US" xlink:label="lab_opk_DrFrostandMrPfennigerMember_CAF7FD8C9BE5073683ACA9799DA1F300" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dr Frost and Mr Pfenniger </link:label>
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<link:label id="lab_opk_FrostRealEstateHoldingsLLCMember_45B753D525B5276367F0A9799DA18F88_verboseLabel_en-US" xlink:label="lab_opk_FrostRealEstateHoldingsLLCMember_45B753D525B5276367F0A9799DA18F88" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Frost Real Estate Holdings LLC </link:label>
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<link:label id="lab_opk_ChromadexCorporationMember_32D5F84153C956FA05B7A9799DA2A182_verboseLabel_en-US" xlink:label="lab_opk_ChromadexCorporationMember_32D5F84153C956FA05B7A9799DA2A182" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> ChromaDex Corporation </link:label>
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<link:label id="lab_opk_CocrystalMember_8A0F4D8B7D14C71517F8A9799DA27BE4_verboseLabel_en-US" xlink:label="lab_opk_CocrystalMember_8A0F4D8B7D14C71517F8A9799DA27BE4" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> COCP </link:label>
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<link:label id="lab_opk_EloxxPharmaceuticalsMember_C712B3FBD21D4C6FD8B7A9799DA28EF9_terseLabel_en-US" xlink:label="lab_opk_EloxxPharmaceuticalsMember_C712B3FBD21D4C6FD8B7A9799DA28EF9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Eloxx Pharmaceuticals </link:label>
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<link:label id="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344_terseLabel_en-US" xlink:label="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> NIMS </link:label>
<link:label id="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344_label_en-US" xlink:label="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> NIMS [Member] </link:label>
<link:label id="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344_documentation_en-US" xlink:label="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> NIMS [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_NIMSMember" xlink:label="loc_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:to="lab_opk_NIMSMember_EB0DE2118AC34B84F3E2A9799DA2D344" xlink:type="arc"/>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_4EFC1C53C63C6146B09FA9799DA2BFB5_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_4EFC1C53C63C6146B09FA9799DA2BFB5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock ownership percentage </link:label>
<link:label id="lab_us-gaap_VariableInterestEntityOwnershipPercentage_4EFC1C53C63C6146B09FA9799DA2BFB5_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityOwnershipPercentage_4EFC1C53C63C6146B09FA9799DA2BFB5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Interest Entity, Qualitative or Quantitative Information, Ownership Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="loc_us-gaap_VariableInterestEntityOwnershipPercentage_4EFC1C53C63C6146B09FA9799DA2BFB5" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_2AF06B59CC355BA24A4FA9799DA2177B_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_2AF06B59CC355BA24A4FA9799DA2177B" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investment, ownership percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_2AF06B59CC355BA24A4FA9799DA2177B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_2AF06B59CC355BA24A4FA9799DA2177B" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_2AF06B59CC355BA24A4FA9799DA2177B" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D362750254DC8A6CF537A9799DA218C0_verboseLabel_en-US" xlink:label="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D362750254DC8A6CF537A9799DA218C0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Available-for-sale investment, ownership percentage </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AvailableforSaleSecuritiesOwnershipPercentage" xlink:label="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_D362750254DC8A6CF537A9799DA218C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforSaleSecuritiesOwnershipPercentage_D362750254DC8A6CF537A9799DA218C0" xlink:to="lab_opk_AvailableforSaleSecuritiesOwnershipPercentage_D362750254DC8A6CF537A9799DA218C0" xlink:type="arc"/>
<link:label id="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A_terseLabel_en-US" xlink:label="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ownership percentage, cost method </link:label>
<link:label id="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A_label_en-US" xlink:label="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost Method Investment, Ownership Percentage </link:label>
<link:label id="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A_documentation_en-US" xlink:label="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cost Method Investment, Ownership Percentage </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CostMethodInvestmentOwnershipPercentage" xlink:label="loc_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:to="lab_opk_CostMethodInvestmentOwnershipPercentage_F82EB3FE4D373AEE8623A9799DA3D23A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3_terseLabel_en-US" xlink:label="lab_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost method investment </link:label>
<link:label id="lab_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3_label_en-US" xlink:label="lab_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost Method Investments, Original Cost </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CostMethodInvestmentsOriginalCost" xlink:label="loc_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3" xlink:to="lab_us-gaap_CostMethodInvestmentsOriginalCost_F5483B859F14EA5F5CA7A9799DA32FD3" xlink:type="arc"/>
<link:label id="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B_terseLabel_en-US" xlink:label="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost method investment, shares purchased during period (in shares) </link:label>
<link:label id="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B_label_en-US" xlink:label="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost Method Investment, Shares Purchased in Period </link:label>
<link:label id="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B_documentation_en-US" xlink:label="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cost Method Investment, Shares Purchased in Period </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CostMethodInvestmentSharesPurchasedinPeriod" xlink:label="loc_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:to="lab_opk_CostMethodInvestmentSharesPurchasedinPeriod_5B7CAE247E949AB8E3B4A9799DA3445B" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional investment in equity method investment </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7" xlink:to="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_A69DA61142D8381D8BCAA9799DA3D1B7" xlink:type="arc"/>
<link:label id="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405_terseLabel_en-US" xlink:label="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity method investment, additional investment in period (in shares) </link:label>
<link:label id="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405_label_en-US" xlink:label="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Shares Purchased In Period </link:label>
<link:label id="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405_documentation_en-US" xlink:label="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity Method Investment, Shares Purchased In Period </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_EquityMethodInvestmentSharesPurchasedInPeriod" xlink:label="loc_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:to="lab_opk_EquityMethodInvestmentSharesPurchasedInPeriod_05075F45A971313A2BDCA9799DA36405" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FE4211EC43AC43C9F4CBA9799DA3D947_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FE4211EC43AC43C9F4CBA9799DA3D947" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate on related party loan </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FE4211EC43AC43C9F4CBA9799DA3D947" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FE4211EC43AC43C9F4CBA9799DA3D947" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_FE4211EC43AC43C9F4CBA9799DA3D947" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Available-for-sale investment, additional investment in period </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE" xlink:to="lab_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_9491336C060B02A9F98CA9799DA368DE" xlink:type="arc"/>
<link:label id="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2_terseLabel_en-US" xlink:label="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Available-for-sale investment, additional investment in period (in shares) </link:label>
<link:label id="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2_label_en-US" xlink:label="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Number of Shares Purchased in Period </link:label>
<link:label id="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2_documentation_en-US" xlink:label="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Number of Shares Purchased in Period </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod" xlink:label="loc_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:to="lab_opk_AvailableforsaleSecuritiesNumberofSharesPurchasedinPeriod_8A55DEF419E198A76995A9799DA3E5A2" xlink:type="arc"/>
<link:label id="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075_terseLabel_en-US" xlink:label="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Related party future contribution </link:label>
<link:label id="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075_label_en-US" xlink:label="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction, Future Contributions </link:label>
<link:label id="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075_documentation_en-US" xlink:label="lab_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Related Party Transaction, Future Contributions </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_RelatedPartyTransactionFutureContributions" xlink:label="loc_opk_RelatedPartyTransactionFutureContributions_95567B38609F4E1D5E31A9799DA3D075" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AreaOfRealEstateProperty_B8A101F70B7D37F448E1A9799DA3E05A_terseLabel_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_B8A101F70B7D37F448E1A9799DA3E05A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Area of real estate property (in square feet) </link:label>
<link:label id="lab_us-gaap_AreaOfRealEstateProperty_B8A101F70B7D37F448E1A9799DA3E05A_label_en-US" xlink:label="lab_us-gaap_AreaOfRealEstateProperty_B8A101F70B7D37F448E1A9799DA3E05A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Area of Real Estate Property </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AreaOfRealEstateProperty" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_B8A101F70B7D37F448E1A9799DA3E05A" xlink:type="locator"/>
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<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lease payments per month in first year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year One </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OperatingLeasesMonthlyPaymentsYearOne" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearOne_0E1507D9234879AB727DA9799DA33910" xlink:type="arc"/>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7_terseLabel_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lease payments per month in third year </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7_label_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Three </link:label>
<link:label id="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7_documentation_en-US" xlink:label="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Operating Leases, Monthly Payments, Year Three </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OperatingLeasesMonthlyPaymentsYearThree" xlink:label="loc_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:to="lab_opk_OperatingLeasesMonthlyPaymentsYearThree_FE29D2F3D6B840131067A9799DA34DA7" xlink:type="arc"/>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reimbursement paid to related party for travel </link:label>
<link:label id="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Related Party Transaction, Expenses from Transactions with Related Party </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17" xlink:to="lab_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_7941EB5831D9CC1BA7E7A9799DA38E17" xlink:type="arc"/>
<link:label id="lab_opk_DiagnosticsMember_C918AB654DC357461F2C76581D5FAAD8_verboseLabel_en-US" xlink:label="lab_opk_DiagnosticsMember_C918AB654DC357461F2C76581D5FAAD8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Diagnostics </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_DiagnosticsMember" xlink:label="loc_opk_DiagnosticsMember_C918AB654DC357461F2C76581D5FAAD8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_DiagnosticsMember_C918AB654DC357461F2C76581D5FAAD8" xlink:to="lab_opk_DiagnosticsMember_C918AB654DC357461F2C76581D5FAAD8" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating Segments </link:label>
<link:label id="lab_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196_label_en-US" xlink:label="lab_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Segments [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196" xlink:to="lab_us-gaap_OperatingSegmentsMember_FE4EDDA4C986640D69CC76581D5F3196" xlink:type="arc"/>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973_terseLabel_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate </link:label>
<link:label id="lab_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973_label_en-US" xlink:label="lab_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corporate, Non-Segment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973" xlink:to="lab_us-gaap_CorporateNonSegmentMember_AD16D20C6B9893BC7A0E76581D602973" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE_terseLabel_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:label id="lab_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE_label_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE" xlink:to="lab_us-gaap_StatementGeographicalAxis_9C01036974817AA014B576581D60D6DE" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58_label_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58" xlink:to="lab_us-gaap_SegmentGeographicalDomain_E0DAC27A1CA5AA5E4A0576581D60BB58" xlink:type="arc"/>
<link:label id="lab_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272_verboseLabel_en-US" xlink:label="lab_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> United States </link:label>
<link:label id="lab_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272_label_en-US" xlink:label="lab_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> UNITED STATES </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272" xlink:to="lab_country_US_D9C6FF5E0CDA24DF7BEC76581D60E272" xlink:type="arc"/>
<link:label id="lab_country_IE_B511E97F39377B982F8A76581D608F9E_terseLabel_en-US" xlink:label="lab_country_IE_B511E97F39377B982F8A76581D608F9E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ireland </link:label>
<link:label id="lab_country_IE_B511E97F39377B982F8A76581D608F9E_label_en-US" xlink:label="lab_country_IE_B511E97F39377B982F8A76581D608F9E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> IRELAND </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_IE" xlink:label="loc_country_IE_B511E97F39377B982F8A76581D608F9E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IE_B511E97F39377B982F8A76581D608F9E" xlink:to="lab_country_IE_B511E97F39377B982F8A76581D608F9E" xlink:type="arc"/>
<link:label id="lab_country_CL_C8840D3DCAFAFB3F557376581D601E38_verboseLabel_en-US" xlink:label="lab_country_CL_C8840D3DCAFAFB3F557376581D601E38" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Chile </link:label>
<link:label id="lab_country_CL_C8840D3DCAFAFB3F557376581D601E38_label_en-US" xlink:label="lab_country_CL_C8840D3DCAFAFB3F557376581D601E38" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> CHILE </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_CL" xlink:label="loc_country_CL_C8840D3DCAFAFB3F557376581D601E38" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_CL_C8840D3DCAFAFB3F557376581D601E38" xlink:to="lab_country_CL_C8840D3DCAFAFB3F557376581D601E38" xlink:type="arc"/>
<link:label id="lab_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1_verboseLabel_en-US" xlink:label="lab_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Spain </link:label>
<link:label id="lab_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1_label_en-US" xlink:label="lab_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SPAIN </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_ES" xlink:label="loc_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1" xlink:to="lab_country_ES_1DF56F1E5FEAA6863BFC76581D6021F1" xlink:type="arc"/>
<link:label id="lab_country_IL_39E0EF25266DD05EB93876581D60465A_verboseLabel_en-US" xlink:label="lab_country_IL_39E0EF25266DD05EB93876581D60465A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Israel </link:label>
<link:label id="lab_country_IL_39E0EF25266DD05EB93876581D60465A_label_en-US" xlink:label="lab_country_IL_39E0EF25266DD05EB93876581D60465A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ISRAEL </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_IL" xlink:label="loc_country_IL_39E0EF25266DD05EB93876581D60465A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IL_39E0EF25266DD05EB93876581D60465A" xlink:to="lab_country_IL_39E0EF25266DD05EB93876581D60465A" xlink:type="arc"/>
<link:label id="lab_country_MX_BEAD23EE45869D8C109A76581D60BDF8_verboseLabel_en-US" xlink:label="lab_country_MX_BEAD23EE45869D8C109A76581D60BDF8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Mexico </link:label>
<link:label id="lab_country_MX_BEAD23EE45869D8C109A76581D60BDF8_label_en-US" xlink:label="lab_country_MX_BEAD23EE45869D8C109A76581D60BDF8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MEXICO </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_MX" xlink:label="loc_country_MX_BEAD23EE45869D8C109A76581D60BDF8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_MX_BEAD23EE45869D8C109A76581D60BDF8" xlink:to="lab_country_MX_BEAD23EE45869D8C109A76581D60BDF8" xlink:type="arc"/>
<link:label id="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81_terseLabel_en-US" xlink:label="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other </link:label>
<link:label id="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81_label_en-US" xlink:label="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Countries [Member] </link:label>
<link:label id="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81_documentation_en-US" xlink:label="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Other Countries [Member] </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_OtherCountriesMember" xlink:label="loc_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:to="lab_opk_OtherCountriesMember_DC26BB1B19899C584A2B76581D601D81" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueServicesNet_984646E526B796387C8276581D603405_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueServicesNet_984646E526B796387C8276581D603405" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from services </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueServicesNet" xlink:label="loc_us-gaap_SalesRevenueServicesNet_984646E526B796387C8276581D603405" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueServicesNet_984646E526B796387C8276581D603405" xlink:to="lab_us-gaap_SalesRevenueServicesNet_984646E526B796387C8276581D603405" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_47E3C33D821D2BCCD6DA76581D604AFE_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_47E3C33D821D2BCCD6DA76581D604AFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_47E3C33D821D2BCCD6DA76581D604AFE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OperatingIncomeLoss_D0942EFAD7E0A3DEAF5A76581D606606_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_D0942EFAD7E0A3DEAF5A76581D606606" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Operating income (loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_D0942EFAD7E0A3DEAF5A76581D606606" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:label id="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858_label_en-US" xlink:label="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Noncash or Part Noncash Acquisition, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoncashOrPartNoncashAcquisitionNameDomain" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858" xlink:to="lab_us-gaap_NoncashOrPartNoncashAcquisitionNameDomain_091FC633FEDAA38B86879FA27CA89858" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:label id="lab_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6_label_en-US" xlink:label="lab_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6" xlink:to="lab_us-gaap_StatementLineItems_F1DF3049E810C0F4355B9FA27CA938E6" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from operating activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_917C41256EFB9AB0C7779FA27CA90B2D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProfitLoss_5BC7C719D05E807F85179FA27CA9B2DB_verboseLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss_5BC7C719D05E807F85179FA27CA9B2DB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Net income (loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_5BC7C719D05E807F85179FA27CA9B2DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss_5BC7C719D05E807F85179FA27CA9B2DB" xlink:to="lab_us-gaap_ProfitLoss_5BC7C719D05E807F85179FA27CA9B2DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Adjustments to reconcile net income (loss) to net cash provided by operating activities: </link:label>
<link:label id="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594_label_en-US" xlink:label="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594" xlink:to="lab_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_7322C592A0BA8A888FC09FA27CA94594" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3_verboseLabel_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash interest </link:label>
<link:label id="lab_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3_label_en-US" xlink:label="lab_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Paid-in-Kind Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaidInKindInterest" xlink:label="loc_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3" xlink:to="lab_us-gaap_PaidInKindInterest_7F63C65C66AD49BD7FC99FA27CA918D3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_25DF2822C85A6B0F55159FA27CA94BB6_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_25DF2822C85A6B0F55159FA27CA94BB6" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of deferred financing costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_25DF2822C85A6B0F55159FA27CA94BB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_25DF2822C85A6B0F55159FA27CA94BB6" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_25DF2822C85A6B0F55159FA27CA94BB6" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_D94F105B4295D36619319FA27CA99F38_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_D94F105B4295D36619319FA27CA99F38" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Losses from investments in investees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_D94F105B4295D36619319FA27CA99F38" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments_D94F105B4295D36619319FA27CA99F38" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments_D94F105B4295D36619319FA27CA99F38" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_FCE8611C28BC5185B5A59FA27CA97ED3_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_FCE8611C28BC5185B5A59FA27CA97ED3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity-based compensation – employees and non-employees </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_FCE8611C28BC5185B5A59FA27CA97ED3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_FCE8611C28BC5185B5A59FA27CA97ED3" xlink:to="lab_us-gaap_ShareBasedCompensation_FCE8611C28BC5185B5A59FA27CA97ED3" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Realized loss (gain) on equity securities and disposal of fixed assets </link:label>
<link:label id="lab_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20_label_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Sale of Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20" xlink:to="lab_us-gaap_GainLossOnSaleOfInvestments_13A24400CAF32F48EAD39FA27CA90F20" xlink:type="arc"/>
<link:label id="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73997FAA8B1238D5248D9FA27CAAA42A_negatedLabel_en-US" xlink:label="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73997FAA8B1238D5248D9FA27CAAA42A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of derivative instruments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73997FAA8B1238D5248D9FA27CAAA42A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73997FAA8B1238D5248D9FA27CAAA42A" xlink:to="lab_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_73997FAA8B1238D5248D9FA27CAAA42A" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_525A8C68A40C975294159FA27CAA7294_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_525A8C68A40C975294159FA27CAA7294" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_525A8C68A40C975294159FA27CAA7294" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_525A8C68A40C975294159FA27CAA7294" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_525A8C68A40C975294159FA27CAA7294" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_72FE73AF0B83F36F7CCF9FA27CAAD27E_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_72FE73AF0B83F36F7CCF9FA27CAAD27E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred income tax benefit </link:label>
<link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_72FE73AF0B83F36F7CCF9FA27CAAD27E_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefit_72FE73AF0B83F36F7CCF9FA27CAAD27E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_72FE73AF0B83F36F7CCF9FA27CAAD27E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_08C504DF080AEA03CD739FA27CAAA8BE_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_08C504DF080AEA03CD739FA27CAAA8BE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Changes in assets and liabilities, net of the effects of acquisitions: </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_08C504DF080AEA03CD739FA27CAAA8BE_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_08C504DF080AEA03CD739FA27CAAA8BE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Operating Capital [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_08C504DF080AEA03CD739FA27CAAA8BE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_CE3ACD1868F9D6A66E0D9FA27CAA2061_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_CE3ACD1868F9D6A66E0D9FA27CAA2061" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_CE3ACD1868F9D6A66E0D9FA27CAA2061_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_CE3ACD1868F9D6A66E0D9FA27CAA2061" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_CE3ACD1868F9D6A66E0D9FA27CAA2061" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_EBAA4487A5ED6120B1109FA27CAAD4FF_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_EBAA4487A5ED6120B1109FA27CAAD4FF" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Inventory, net </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_EBAA4487A5ED6120B1109FA27CAAD4FF_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_EBAA4487A5ED6120B1109FA27CAAD4FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Inventories </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_EBAA4487A5ED6120B1109FA27CAAD4FF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_0C69A5907394682FC9219FA27CAA6EEB_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_0C69A5907394682FC9219FA27CAA6EEB" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other current assets and prepaid expenses </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_0C69A5907394682FC9219FA27CAA6EEB_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_0C69A5907394682FC9219FA27CAA6EEB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Prepaid Expense and Other Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_0C69A5907394682FC9219FA27CAA6EEB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8CE674B068B1935B475C9FA27CAA8969_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8CE674B068B1935B475C9FA27CAA8969" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other assets </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8CE674B068B1935B475C9FA27CAA8969_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8CE674B068B1935B475C9FA27CAA8969" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Other Operating Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8CE674B068B1935B475C9FA27CAA8969" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_8AE5E2661799501A3B099FA27CAA9E17_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_8AE5E2661799501A3B099FA27CAA9E17" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayable_8AE5E2661799501A3B099FA27CAA9E17_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayable_8AE5E2661799501A3B099FA27CAA9E17" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Payable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_8AE5E2661799501A3B099FA27CAA9E17" xlink:type="locator"/>
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<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734_terseLabel_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency measurement </link:label>
<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734_label_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Foreign Currency Measurement </link:label>
<link:label id="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734_documentation_en-US" xlink:label="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Foreign Currency Measurement </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_IncreaseDecreaseinForeignCurrencyMeasurement" xlink:label="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:to="lab_opk_IncreaseDecreaseinForeignCurrencyMeasurement_98550C4128086A24072A9FA27CAAE734" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Deferred revenue </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Deferred Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5" xlink:to="lab_us-gaap_IncreaseDecreaseInDeferredRevenue_A4DCE8BC311138C461679FA27CAAE3A5" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Accrued expenses and other liabilities </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accrued Liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1" xlink:to="lab_us-gaap_IncreaseDecreaseInAccruedLiabilities_113904F735488B30D5D69FA27CAA39A1" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by (used in) operating activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_509AAFE708D62FD166D69FA27CAAB97C" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from investing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D35364118FDC576E34BA9FA27CAA0DB0" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Investments in investees </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32" xlink:to="lab_us-gaap_PaymentsToAcquireInvestments_EDF1EA501297E4A26AB39FA27CAA1A32" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Purchase of marketable securities </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Marketable Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5" xlink:to="lab_us-gaap_PaymentsToAcquireMarketableSecurities_B0212FB53B50C7247FE89FA27CAA28D5" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from the sale of property, plant and equipment </link:label>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Sale of Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725" xlink:to="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_4A06E46894119C0A54089FA27CAB9725" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_3E35A920D4C69FF9E3D09FA27CABFCCA_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_3E35A920D4C69FF9E3D09FA27CABFCCA" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Capital expenditures </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireProductiveAssets_3E35A920D4C69FF9E3D09FA27CABFCCA_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireProductiveAssets_3E35A920D4C69FF9E3D09FA27CABFCCA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Productive Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_3E35A920D4C69FF9E3D09FA27CABFCCA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash used in investing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_4AB19E4E36F35D4D87AB9FA27CAB2E84" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_21F2642C852B44ADBB4B9FA27CAB9744_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_21F2642C852B44ADBB4B9FA27CAB9744" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash flows from financing activities: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_21F2642C852B44ADBB4B9FA27CAB9744_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_21F2642C852B44ADBB4B9FA27CAB9744" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_21F2642C852B44ADBB4B9FA27CAB9744" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_B815EFD754EB038680FF9FA27CAB1A0A_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_B815EFD754EB038680FF9FA27CAB1A0A" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from the exercise of Common Stock options and warrants </link:label>
<link:label id="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_B815EFD754EB038680FF9FA27CAB1A0A_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_B815EFD754EB038680FF9FA27CAB1A0A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Issuance or Sale of Equity </link:label>
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<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_E734BECBD65C1EAF50789FA27CAB7A0F_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_E734BECBD65C1EAF50789FA27CAB7A0F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Borrowings on lines of credit </link:label>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_E734BECBD65C1EAF50789FA27CAB7A0F_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_E734BECBD65C1EAF50789FA27CAB7A0F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_E734BECBD65C1EAF50789FA27CAB7A0F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_280F0496790C1C34F1B29FA27CAB92E4_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_280F0496790C1C34F1B29FA27CAB92E4" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Repayments of lines of credit </link:label>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_280F0496790C1C34F1B29FA27CAB92E4_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_280F0496790C1C34F1B29FA27CAB92E4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Repayments of Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_280F0496790C1C34F1B29FA27CAB92E4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by (used in) financing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_22C43F4D6EC5C02974F09FA27CAB6A55" xlink:type="arc"/>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F_verboseLabel_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Effect of exchange rate changes on cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F_label_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effect of Exchange Rate on Cash and Cash Equivalents </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F" xlink:to="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_32C246909662AFC54E1B9FA27CAB218F" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2_totalLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net decrease in cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Period Increase (Decrease) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2" xlink:to="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_312E2BA1822C424CCFD39FA27CAB47E2" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_20FA80266F4B08ADFCE19FA27CAB5719_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_20FA80266F4B08ADFCE19FA27CAB5719" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at beginning of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_20FA80266F4B08ADFCE19FA27CAB5719" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_20FA80266F4B08ADFCE19FA27CAB5719" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_20FA80266F4B08ADFCE19FA27CAB5719" xlink:type="arc"/>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_9D1A506D9F51AF8AB22A9FA27CABBC2D_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_9D1A506D9F51AF8AB22A9FA27CABBC2D" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at end of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_9D1A506D9F51AF8AB22A9FA27CABBC2D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> SUPPLEMENTAL INFORMATION: </link:label>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53_label_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Cash Flow Information [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53" xlink:to="lab_us-gaap_SupplementalCashFlowInformationAbstract_B8EA5E7451052D9F91339FA27CABEC53" xlink:type="arc"/>
<link:label id="lab_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest paid </link:label>
<link:label id="lab_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE_label_en-US" xlink:label="lab_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Paid </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE" xlink:to="lab_us-gaap_InterestPaid_3DD0CA805CFA06E0E9ED9FA27CAB9CAE" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_47028FD4F2E9325AD6849FA27CAB9C51_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_47028FD4F2E9325AD6849FA27CAB9C51" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes paid, net </link:label>
<link:label id="lab_us-gaap_IncomeTaxesPaidNet_47028FD4F2E9325AD6849FA27CAB9C51_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaidNet_47028FD4F2E9325AD6849FA27CAB9C51" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Taxes Paid, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_47028FD4F2E9325AD6849FA27CAB9C51" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_AFE6EB1B5C8876E5CA889FA27CABF2C3_verboseLabel_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_AFE6EB1B5C8876E5CA889FA27CABF2C3" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Non-cash financing: </link:label>
<link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_AFE6EB1B5C8876E5CA889FA27CABF2C3_label_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_AFE6EB1B5C8876E5CA889FA27CABF2C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_AFE6EB1B5C8876E5CA889FA27CABF2C3" xlink:type="locator"/>
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<link:label id="lab_opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract_B7D39AF42179DFF981F69FA27CAB66CD_terseLabel_en-US" xlink:label="lab_opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract_B7D39AF42179DFF981F69FA27CAB66CD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued upon the conversion of: </link:label>
<link:label id="lab_opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract_B7D39AF42179DFF981F69FA27CAB66CD_label_en-US" xlink:label="lab_opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract_B7D39AF42179DFF981F69FA27CAB66CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Issued in the Conversion of Stock and Debt Instruments [Abstract] </link:label>
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<link:loc xlink:href="opk-20170630.xsd#opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract" xlink:label="loc_opk_SharesIssuedintheConversionofStockandDebtInstrumentsAbstract_B7D39AF42179DFF981F69FA27CAB66CD" xlink:type="locator"/>
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<link:label id="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F_verboseLabel_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock options and warrants, surrendered in net exercise </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F_label_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock Warrants Net Exercised </link:label>
<link:label id="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F_documentation_en-US" xlink:label="lab_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Common stock warrants net exercised. </link:label>
<link:loc xlink:href="opk-20170630.xsd#opk_CommonStockWarrantsNetExercised" xlink:label="loc_opk_CommonStockWarrantsNetExercised_9ACBD84E2A44E802039C9FA27CACA80F" xlink:type="locator"/>
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<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028_terseLabel_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Issuance of capital stock for contingent consideration settlement: </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028_label_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
<link:label id="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028_documentation_en-US" xlink:label="lab_opk_StockIssuedDuringPeriodSharesAcquisitionAbstract_9C20134501284CF1F5479FA27CAC8028" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period Shares Acquisition [Abstract] </link:label>
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