SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-K’ for 12/31/20 – ‘EX-101.CAL’

On:  Thursday, 2/18/21, at 4:09pm ET   ·   For:  12/31/20   ·   Accession #:  944809-21-15   ·   File #:  1-33528

Previous ‘10-K’:  ‘10-K’ on 3/2/20 for 12/31/19   ·   Next:  ‘10-K’ on 3/1/22 for 12/31/21   ·   Latest:  ‘10-K’ on 3/1/24 for 12/31/23   ·   50 References:   

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M

Annual Report   —   Form 10-K
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   2.05M 
 2: EX-3.2      Articles of Incorporation/Organization or Bylaws    HTML    104K 
 3: EX-4.6      Instrument Defining the Rights of Security Holders  HTML     38K 
 4: EX-21       Subsidiaries List                                   HTML     32K 
 5: EX-23.1     Consent of Expert or Counsel                        HTML     30K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     33K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     33K 
 8: EX-32.1     Certification -- §906 - SOA'02                      HTML     29K 
 9: EX-32.2     Certification -- §906 - SOA'02                      HTML     29K 
16: R1          Cover Page                                          HTML     90K 
17: R2          Consolidated Balance Sheets                         HTML    121K 
18: R3          Consolidated Balance Sheets (Parenthetical)         HTML     37K 
19: R4          Consolidated Statements of Operations               HTML    102K 
20: R5          Consolidated Statements of Comprehensive Income     HTML     49K 
                (Loss)                                                           
21: R6          Consolidated Statements of Equity                   HTML     95K 
22: R7          Consolidated Statements of Cash Flows               HTML    139K 
23: R8          Business and Organization                           HTML     34K 
24: R9          Impact of COVID-19                                  HTML     38K 
25: R10         Summary of Significant Accounting Policies          HTML     69K 
26: R11         Income (loss) Per Share                             HTML     34K 
27: R12         Investments                                         HTML     62K 
28: R13         Composition of Certain Financial Statement          HTML    166K 
                Captions                                                         
29: R14         Debt                                                HTML    111K 
30: R15         Shareholders' Equity                                HTML     36K 
31: R16         Accumulated Other Comprehensive Income (Loss)       HTML     41K 
32: R17         Equity-Based Compensation                           HTML     61K 
33: R18         Income Taxes                                        HTML    140K 
34: R19         Related Party Transactions                          HTML     44K 
35: R20         Employee Benefit Plans                              HTML     34K 
36: R21         Commitments and Contingencies                       HTML     43K 
37: R22         Revenue Recognition                                 HTML    117K 
38: R23         Strategic Alliances                                 HTML     50K 
39: R24         Leases                                              HTML    112K 
40: R25         Segments                                            HTML    112K 
41: R26         Fair Value Measurements                             HTML     93K 
42: R27         Derivative Contracts                                HTML     49K 
43: R28         Selected Quarterly Financial Data (Unaudited)       HTML     54K 
44: R29         Subsequent Events                                   HTML     31K 
45: R30         Summary of Significant Accounting Policies          HTML    125K 
                (Policies)                                                       
46: R31         Investments (Tables)                                HTML     55K 
47: R32         Composition of Certain Financial Statement          HTML    167K 
                Captions (Tables)                                                
48: R33         Debt (Tables)                                       HTML     98K 
49: R34         Accumulated Other Comprehensive Income (Loss)       HTML     40K 
                (Tables)                                                         
50: R35         Equity-Based Compensation (Tables)                  HTML     57K 
51: R36         Income Taxes (Tables)                               HTML    136K 
52: R37         Revenue Recognition (Tables)                        HTML     95K 
53: R38         Leases (Tables)                                     HTML     85K 
54: R39         Segments (Tables)                                   HTML    110K 
55: R40         Fair Value Measurements (Tables)                    HTML     93K 
56: R41         Derivative Contracts (Tables)                       HTML     51K 
57: R42         Selected Quarterly Financial Data (Unaudited)       HTML     54K 
                (Tables)                                                         
58: R43         Business and Organization - Narrative (Details)     HTML     30K 
59: R44         Impact of COVID-19 (Details)                        HTML     41K 
60: R45         Summary of Significant Accounting Policies -        HTML    130K 
                Narrative (Details)                                              
61: R46         Income (loss) Per Share - Narrative (Details)       HTML     41K 
62: R47         Investments - Accounting Method, Carrying Value     HTML     44K 
                and Underlying Equity in Net Assets of                           
                Unconsolidated Investments (Details)                             
63: R48         Investments - Narrative (Details)                   HTML    111K 
64: R49         Investments - Schedule of Net Gains and Losses on   HTML     36K 
                Equity Securities (Details)                                      
65: R50         Composition of Certain Financial Statement          HTML    166K 
                Captions - Composition of Certain Financial                      
                Statement Captions (Details)                                     
66: R51         Composition of Certain Financial Statement          HTML     64K 
                Captions - Narrative (Details)                                   
67: R52         Composition of Certain Financial Statement          HTML     44K 
                Captions - Summary of Valuation Allowance                        
                (Details)                                                        
68: R53         Composition of Certain Financial Statement          HTML     80K 
                Captions - Changes in Goodwill (Details)                         
69: R54         Debt - Schedule of Debt (Details)                   HTML     59K 
70: R55         Debt - Narrative (Details)                          HTML    224K 
71: R56         Debt - Schedule of Notes (Details)                  HTML     56K 
72: R57         Debt - Summary of Lines of Credit (Details)         HTML     72K 
73: R58         Debt - Mortgage Notes and Other Debt (Details)      HTML     38K 
74: R59         Shareholders' Equity - Narrative (Details)          HTML     80K 
75: R60         Accumulated Other Comprehensive Income (Loss) -     HTML     39K 
                Changes in Accumulated Other Comprehensive Income,               
                Net of Tax (Details)                                             
76: R61         Equity-Based Compensation - Narrative (Details)     HTML     77K 
77: R62         Equity-Based Compensation - Summary of              HTML     47K 
                Option-Pricing Formula (Details)                                 
78: R63         Equity-Based Compensation - Summary of Option       HTML     80K 
                Activity (Details)                                               
79: R64         Income Taxes - Components of Income Tax Benefit     HTML     57K 
                (Provision) (Details)                                            
80: R65         Income Taxes - Components of Deferred Income Tax    HTML     89K 
                Assets and Liabilities (Details)                                 
81: R66         Income Taxes - Narrative (Details)                  HTML     61K 
82: R67         Income Taxes - Change in Gross Unrecognized Income  HTML     41K 
                (Details)                                                        
83: R68         Income Taxes - Schedule of Difference in Federal    HTML     67K 
                and Effective Tax Rate (Details)                                 
84: R69         Income Taxes - Reconciliation Losses Before Tax,    HTML     36K 
                US and Foreign Jurisdictions (Details)                           
85: R70         Related Party Transactions - Narrative (Details)    HTML    262K 
86: R71         Employee Benefit Plans - Narrative (Details)        HTML     38K 
87: R72         Commitments and Contingencies - Narrative           HTML     62K 
                (Details)                                                        
88: R73         Revenue Recognition - Narrative (Details)           HTML     65K 
89: R74         Revenue Recognition - Schedule of Disaggregation    HTML     50K 
                of Revenue (Details)                                             
90: R75         Revenue Recognition - Schedule of Product Sales     HTML     65K 
                Allowances and Accruals (Details)                                
91: R76         Revenue Recognition - Changes in Contractual        HTML     33K 
                Liabilities Balance (Details)                                    
92: R77         Strategic Alliances - Narrative (Details)           HTML    133K 
93: R78         Leases - Lease Assets and Liabilities (Details)     HTML     59K 
94: R79         Leases - Lease Liability Maturity (Details)         HTML     69K 
95: R80         Leases - Narrative (Details)                        HTML     35K 
96: R81         Leases - Supplemental Cash Flow Information         HTML     37K 
                (Details)                                                        
97: R82         Segments - Narrative (Details)                      HTML     41K 
98: R83         Segments - Operations and Assets for Operating      HTML    125K 
                Segments and Geographic Information (Details)                    
99: R84         Segments - Property, Plant and Equipment, Net by    HTML     36K 
                Jurisdiction (Details)                                           
100: R85         Fair Value Measurements - Financial Assets and      HTML     66K  
                Liabilities Measured at Fair Value on a Recurring                
                Basis (Details)                                                  
101: R86         Fair Value Measurements - Carrying Amount and       HTML     40K  
                Estimated Fair Value of Long-Term Debt (Details)                 
102: R87         Fair Value Measurements - Reconciliation of         HTML     35K  
                Beginning and Ending Balances of Level 3 Assets                  
                and Liabilities (Details)                                        
103: R88         Fair Value Measurements - Narrative (Details)       HTML     36K  
104: R89         Derivative Contracts - Summary of Fair Values and   HTML     42K  
                Presentation of Derivative Financial Instruments                 
                (Details)                                                        
105: R90         Derivative Contracts - Summary of the Losses and    HTML     37K  
                Gains Recorded for the Changes in Fair Values of                 
                Derivative Instruments (Details)                                 
106: R91         Selected Quarterly Financial Data (Unaudited) -     HTML     49K  
                Summary of Selected Quarterly Financial Data                     
                (Unaudited) (Details)                                            
107: R9999       Uncategorized Items - opk-20201231.htm              HTML     37K  
109: XML         IDEA XML File -- Filing Summary                      XML    198K  
15: XML         XBRL Instance -- opk-20201231_htm                    XML   4.10M 
108: EXCEL       IDEA Workbook of Financial Reports                  XLSX    173K  
11: EX-101.CAL  XBRL Calculations -- opk-20201231_cal                XML    356K 
12: EX-101.DEF  XBRL Definitions -- opk-20201231_def                 XML   1.29M 
13: EX-101.LAB  XBRL Labels -- opk-20201231_lab                      XML   2.87M 
14: EX-101.PRE  XBRL Presentations -- opk-20201231_pre               XML   1.76M 
10: EX-101.SCH  XBRL Schema -- opk-20201231                          XSD    261K 
110: JSON        XBRL Instance as JSON Data -- MetaLinks              625±   907K  
111: ZIP         XBRL Zipped Folder -- 0000944809-21-000015-xbrl      Zip    704K

‘EX-101.CAL’   —   XBRL Calculations — opk-20201231_cal

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- Copyright 2021 Workiva -->
<!-- r:0cdcc711-982e-4bc8-9796-0571c76897bd,g:f9be14b8-63fe-4945-add1-8a989ed6e22b -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:roleRef roleURI="http://www.opko.com/role/COVERPAGE" xlink:type="simple" xlink:href="opk-20201231.xsd#COVERPAGE"/>
<link:calculationLink xlink:role="http://www.opko.com/role/COVERPAGE" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedBalanceSheets"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_0b1fe4f1-ddbe-4f2a-999f-f197660d6d50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:to="loc_us-gaap_CommonStockValue_0b1fe4f1-ddbe-4f2a-999f-f197660d6d50" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_2e979462-4e0d-4278-b484-a49bb669cc8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockValue"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:to="loc_us-gaap_TreasuryStockValue_2e979462-4e0d-4278-b484-a49bb669cc8c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_945907d1-0e8a-4f87-bd0b-9d37ace546a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:to="loc_us-gaap_AdditionalPaidInCapital_945907d1-0e8a-4f87-bd0b-9d37ace546a9" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_7d4e2971-c6ff-46e5-98e3-1c48ffb0e3fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_7d4e2971-c6ff-46e5-98e3-1c48ffb0e3fa" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d58a57c0-7b73-492c-aac8-e4c17504d510" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_ea5fe3ee-fd2d-41ed-ae18-1f9962e06c9c" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d58a57c0-7b73-492c-aac8-e4c17504d510" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_c5b87b2c-116b-4c53-b9f2-819ce8c4c872" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_AssetsCurrent_c5b87b2c-116b-4c53-b9f2-819ce8c4c872" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_cf488d9c-cf83-496e-a1e8-c4c5df09c94d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_cf488d9c-cf83-496e-a1e8-c4c5df09c94d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_InProcessResearchandDevelopment_1c23c1d5-14ce-46c4-bdcc-812c1b3ce83d" xlink:href="opk-20201231.xsd#opk_InProcessResearchandDevelopment"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_opk_InProcessResearchandDevelopment_1c23c1d5-14ce-46c4-bdcc-812c1b3ce83d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_4658c1b3-137d-48f0-8674-1bd2e572e55a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_Goodwill_4658c1b3-137d-48f0-8674-1bd2e572e55a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_2a1033d3-541e-49a5-a223-dc890e3190ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermInvestments"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_LongTermInvestments_2a1033d3-541e-49a5-a223-dc890e3190ec" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_f095248f-9685-4822-83fe-5095268c8ed7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_f095248f-9685-4822-83fe-5095268c8ed7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0901e44e-d821-41db-a427-185baec5fa26" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0901e44e-d821-41db-a427-185baec5fa26" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_2d846c6b-12d4-4fa0-bc5a-f71e0fe2996f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
<link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a1f17adc-f9e4-45c9-b47c-2630bfa81453" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_2d846c6b-12d4-4fa0-bc5a-f71e0fe2996f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_0af23fae-d708-46e7-b9ea-341b6966568e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_e7d1e883-4482-4314-a0af-27fadd6d793b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0af23fae-d708-46e7-b9ea-341b6966568e" xlink:to="loc_us-gaap_AccountsPayableCurrent_e7d1e883-4482-4314-a0af-27fadd6d793b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_4e1acef4-105d-4364-9ddf-43b424f1d611" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0af23fae-d708-46e7-b9ea-341b6966568e" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_4e1acef4-105d-4364-9ddf-43b424f1d611" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_0a461101-6253-4092-afbc-29209f640ac2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0af23fae-d708-46e7-b9ea-341b6966568e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_0a461101-6253-4092-afbc-29209f640ac2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_LineofCreditandNotesandLoansPayableCurrent_3f2f7b49-79a9-41ce-a19f-18fd1c5f1fc1" xlink:href="opk-20201231.xsd#opk_LineofCreditandNotesandLoansPayableCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0af23fae-d708-46e7-b9ea-341b6966568e" xlink:to="loc_opk_LineofCreditandNotesandLoansPayableCurrent_3f2f7b49-79a9-41ce-a19f-18fd1c5f1fc1" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_3505e398-c8d8-4704-a10e-fac060d4cb16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_cbb3c1df-d1f1-4007-80c9-88a75f0bdc23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3505e398-c8d8-4704-a10e-fac060d4cb16" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_cbb3c1df-d1f1-4007-80c9-88a75f0bdc23" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_ee8961f1-9f54-4b6b-ae48-266c9d2a75b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3505e398-c8d8-4704-a10e-fac060d4cb16" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_ee8961f1-9f54-4b6b-ae48-266c9d2a75b5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_9c4585fd-ecf9-4afc-8735-e7525a5b39a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3505e398-c8d8-4704-a10e-fac060d4cb16" xlink:to="loc_us-gaap_InventoryNet_9c4585fd-ecf9-4afc-8735-e7525a5b39a5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_7cef214b-e99c-4256-bf86-0c0b3558764c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3505e398-c8d8-4704-a10e-fac060d4cb16" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_7cef214b-e99c-4256-bf86-0c0b3558764c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_b34c1ebb-182a-4c59-ba78-362f41815d5f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_c0bc539f-01d9-4be9-9bef-61e1189b7db6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesNoncurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_b34c1ebb-182a-4c59-ba78-362f41815d5f" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_c0bc539f-01d9-4be9-9bef-61e1189b7db6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_02ea9973-cd5a-4137-a9a2-bd5bb560278d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_b34c1ebb-182a-4c59-ba78-362f41815d5f" xlink:to="loc_us-gaap_LiabilitiesCurrent_02ea9973-cd5a-4137-a9a2-bd5bb560278d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_4042204f-530e-4935-97eb-3515e899cb62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_571ec5f0-9f85-4669-8a5c-cce970cd2759" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4042204f-530e-4935-97eb-3515e899cb62" xlink:to="loc_us-gaap_Liabilities_571ec5f0-9f85-4669-8a5c-cce970cd2759" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_bff4d5e6-5c4d-4e35-b020-580a516f3c83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4042204f-530e-4935-97eb-3515e899cb62" xlink:to="loc_us-gaap_StockholdersEquity_bff4d5e6-5c4d-4e35-b020-580a516f3c83" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_b2234cf1-d11a-4742-bf0c-4d199ea4a574" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesNoncurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_635a0f34-4352-4d6d-bfdd-61fc34e134ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_b2234cf1-d11a-4742-bf0c-4d199ea4a574" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_635a0f34-4352-4d6d-bfdd-61fc34e134ec" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_afbce093-6495-4f96-bd9c-c43403a29cb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_b2234cf1-d11a-4742-bf0c-4d199ea4a574" xlink:to="loc_us-gaap_ConvertibleLongTermNotesPayable_afbce093-6495-4f96-bd9c-c43403a29cb3" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_7fbce95d-b299-44a2-aa3e-781eb9b70988" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_b2234cf1-d11a-4742-bf0c-4d199ea4a574" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_7fbce95d-b299-44a2-aa3e-781eb9b70988" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_6650c0f9-ca43-4f10-a127-9cc5371eeee8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_b2234cf1-d11a-4742-bf0c-4d199ea4a574" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_6650c0f9-ca43-4f10-a127-9cc5371eeee8" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedStatementsofOperations"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1a7a538b-625e-455f-b728-ff45782a4402" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d67a8cfc-a41d-48bc-a87f-7bac75a44b51" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1a7a538b-625e-455f-b728-ff45782a4402" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_d67a8cfc-a41d-48bc-a87f-7bac75a44b51" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_07f9fdfa-30da-4db5-8cbd-d4ae062baeec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_1a7a538b-625e-455f-b728-ff45782a4402" xlink:to="loc_us-gaap_OperatingIncomeLoss_07f9fdfa-30da-4db5-8cbd-d4ae062baeec" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_cfe3a2af-54ef-4c46-8e95-c3027aab7a67" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_61ca9be8-a4d7-4c6d-b722-489cf0dbdc3b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_cfe3a2af-54ef-4c46-8e95-c3027aab7a67" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_61ca9be8-a4d7-4c6d-b722-489cf0dbdc3b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_968f314c-243b-4e36-af69-2082375a4f48" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_cfe3a2af-54ef-4c46-8e95-c3027aab7a67" xlink:to="loc_us-gaap_OperatingExpenses_968f314c-243b-4e36-af69-2082375a4f48" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9ba8f6cb-3b7a-4632-9c4d-44a8c8432d7e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9ba8f6cb-3b7a-4632-9c4d-44a8c8432d7e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_488dbab7-707d-4749-8ea4-7c2da77f7fc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_488dbab7-707d-4749-8ea4-7c2da77f7fc4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_0a5fcdcb-cb30-46a7-9327-8c91a2b50b7e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_0a5fcdcb-cb30-46a7-9327-8c91a2b50b7e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_ae85c5c2-1e8b-49d6-ad9f-c670b7873ab3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_ae85c5c2-1e8b-49d6-ad9f-c670b7873ab3" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_0f2ea935-3afe-4c00-af14-ff3c303d359d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_AssetImpairmentCharges_0f2ea935-3afe-4c00-af14-ff3c303d359d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_7cb12d60-b1b7-434c-b108-0c89f7f2233e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_42f41354-bf77-433b-b0ad-0308d732122f" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_7cb12d60-b1b7-434c-b108-0c89f7f2233e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_c26942a2-0dde-4188-98b1-4a283cabc06e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_InterestIncomeNonoperating_fef7cdf4-086c-4bd1-a224-fcf3e4f24b26" xlink:href="opk-20201231.xsd#opk_InterestIncomeNonoperating"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_c26942a2-0dde-4188-98b1-4a283cabc06e" xlink:to="loc_opk_InterestIncomeNonoperating_fef7cdf4-086c-4bd1-a224-fcf3e4f24b26" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_05ebb0e7-1a1e-4d9d-8e67-731aab2f1d8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_c26942a2-0dde-4188-98b1-4a283cabc06e" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_05ebb0e7-1a1e-4d9d-8e67-731aab2f1d8c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_InterestExpenseNonoperating_da38a16a-cdd5-4051-9240-66b8ca9c5831" xlink:href="opk-20201231.xsd#opk_InterestExpenseNonoperating"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_c26942a2-0dde-4188-98b1-4a283cabc06e" xlink:to="loc_opk_InterestExpenseNonoperating_da38a16a-cdd5-4051-9240-66b8ca9c5831" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_79f3ca0c-7179-455a-be5a-e235cc987dcb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_c26942a2-0dde-4188-98b1-4a283cabc06e" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_79f3ca0c-7179-455a-be5a-e235cc987dcb" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_a09bd113-3dd2-4820-bf3e-ba5c543fb755" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax_c90109f0-4825-4ccd-b299-d4aa8529806b" xlink:href="opk-20201231.xsd#opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a09bd113-3dd2-4820-bf3e-ba5c543fb755" xlink:to="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax_c90109f0-4825-4ccd-b299-d4aa8529806b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncomeLossfromEquityMethodInvestmentsNetofTax_d128f716-0b51-4b32-bbef-a23cf7a7555d" xlink:href="opk-20201231.xsd#opk_IncomeLossfromEquityMethodInvestmentsNetofTax"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a09bd113-3dd2-4820-bf3e-ba5c543fb755" xlink:to="loc_opk_IncomeLossfromEquityMethodInvestmentsNetofTax_d128f716-0b51-4b32-bbef-a23cf7a7555d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax_3d744682-da46-404a-90b8-623975345aba" xlink:href="opk-20201231.xsd#opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_09c466a8-28f9-494c-9281-fbe7de286d13" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax_3d744682-da46-404a-90b8-623975345aba" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_09c466a8-28f9-494c-9281-fbe7de286d13" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3cbd96a5-8f08-46af-9ec5-22f89a543f16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_IncomeLossfromContinuingOperationsBeforeInvestmentsinInvesteesExtraordinaryItemsNetofTax_3d744682-da46-404a-90b8-623975345aba" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3cbd96a5-8f08-46af-9ec5-22f89a543f16" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedStatementsofComprehensiveIncomeLoss"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_6fbf842d-63d6-40e9-9572-92237e358039" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_801b3d57-0389-493a-b173-fbe714469490" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_6fbf842d-63d6-40e9-9572-92237e358039" xlink:to="loc_us-gaap_NetIncomeLoss_801b3d57-0389-493a-b173-fbe714469490" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_19ac1211-fcda-48c4-b492-7537920de4e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_6fbf842d-63d6-40e9-9572-92237e358039" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_19ac1211-fcda-48c4-b492-7537920de4e4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIForAdoptionOfAccountingStandardsUpdateNetOfTax_7bb6e3a2-60ea-48b2-b167-3c52e9532fbb" xlink:href="opk-20201231.xsd#opk_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIForAdoptionOfAccountingStandardsUpdateNetOfTax"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_6fbf842d-63d6-40e9-9572-92237e358039" xlink:to="loc_opk_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIForAdoptionOfAccountingStandardsUpdateNetOfTax_7bb6e3a2-60ea-48b2-b167-3c52e9532fbb" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsofEquity" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedStatementsofEquity"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsofEquity" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="opk-20201231.xsd#ConsolidatedStatementsofCashFlows"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_231d12e7-dbfe-4ba0-ab3c-6f8e0c77c753" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3333f096-46b0-4b65-8c87-eea3770a69bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_231d12e7-dbfe-4ba0-ab3c-6f8e0c77c753" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3333f096-46b0-4b65-8c87-eea3770a69bf" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_103a5b60-1397-4baa-ace5-57083a47336d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_231d12e7-dbfe-4ba0-ab3c-6f8e0c77c753" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_103a5b60-1397-4baa-ace5-57083a47336d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b2f1cc8f-6300-4c46-b6c4-47d6502dfed6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_231d12e7-dbfe-4ba0-ab3c-6f8e0c77c753" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b2f1cc8f-6300-4c46-b6c4-47d6502dfed6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_3db05c5b-4bf2-4ca1-a91a-8fa5338f166b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_231d12e7-dbfe-4ba0-ab3c-6f8e0c77c753" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_3db05c5b-4bf2-4ca1-a91a-8fa5338f166b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_ProceedsFromIssuanceofStockOptionsExercisedandIssuanceofWarrants_f6eb6ccd-9286-41df-b26a-ad9f9781321b" xlink:href="opk-20201231.xsd#opk_ProceedsFromIssuanceofStockOptionsExercisedandIssuanceofWarrants"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_opk_ProceedsFromIssuanceofStockOptionsExercisedandIssuanceofWarrants_f6eb6ccd-9286-41df-b26a-ad9f9781321b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_227b43b7-ac66-4f01-abb5-4d41cb5830a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_ProceedsFromLinesOfCredit_227b43b7-ac66-4f01-abb5-4d41cb5830a5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_d8cfbfd7-7d82-4956-95fb-c213eb722dce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_d8cfbfd7-7d82-4956-95fb-c213eb722dce" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_8ad19e4f-2107-4eaf-b56c-9656a56f65ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_8ad19e4f-2107-4eaf-b56c-9656a56f65ef" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_496ba806-00dd-44a7-a880-8cf7021f8008" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_496ba806-00dd-44a7-a880-8cf7021f8008" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_dcc4dc20-a82a-4eee-9b0a-4c844fabf428" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
<link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_dcc4dc20-a82a-4eee-9b0a-4c844fabf428" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9bf3d3b6-6807-4f8f-8e64-4b7c1f3de050" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
<link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0ce9606f-739b-4729-aa61-457b2df216b6" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9bf3d3b6-6807-4f8f-8e64-4b7c1f3de050" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f8a0d681-d521-453f-a481-42b8b5969011" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_NetIncomeLoss_f8a0d681-d521-453f-a481-42b8b5969011" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_35b2097b-0cb5-4fa6-93ce-ac8e38ca6480" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_35b2097b-0cb5-4fa6-93ce-ac8e38ca6480" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaidInKindInterest_5f3750f3-f096-4355-a8a2-dab12f181064" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaidInKindInterest"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_PaidInKindInterest_5f3750f3-f096-4355-a8a2-dab12f181064" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_ef8b0ce4-b258-4605-8ba8-771c520d4f41" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_ef8b0ce4-b258-4605-8ba8-771c520d4f41" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncomeLossfromEquityMethodInvestmentsNetofTax_8d9f6f44-20f6-40e5-aa25-c9d255091742" xlink:href="opk-20201231.xsd#opk_IncomeLossfromEquityMethodInvestmentsNetofTax"/>
<link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_opk_IncomeLossfromEquityMethodInvestmentsNetofTax_8d9f6f44-20f6-40e5-aa25-c9d255091742" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_ac034bde-da64-40d5-b592-5fd3f822925c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_ShareBasedCompensation_ac034bde-da64-40d5-b592-5fd3f822925c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_ecde8160-9621-4987-8ea6-20b14074b6c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_AssetImpairmentCharges_ecde8160-9621-4987-8ea6-20b14074b6c8" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_0877e195-068a-4cd6-aa63-0413636e6646" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
<link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_0877e195-068a-4cd6-aa63-0413636e6646" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncreaseDecreaseInEquitySecuritiesFVNIAndDerivativeInstruments_655f216b-f3ab-40b4-83f3-0068f6f5951d" xlink:href="opk-20201231.xsd#opk_IncreaseDecreaseInEquitySecuritiesFVNIAndDerivativeInstruments"/>
<link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_opk_IncreaseDecreaseInEquitySecuritiesFVNIAndDerivativeInstruments_655f216b-f3ab-40b4-83f3-0068f6f5951d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_1da2cd84-c4e8-413f-bfaa-18f822717bf6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
<link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_1da2cd84-c4e8-413f-bfaa-18f822717bf6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_42f36760-04c9-40ca-b6eb-561ecbe5fe40" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
<link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_42f36760-04c9-40ca-b6eb-561ecbe5fe40" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f5a5d290-75b5-47c9-9d56-586f010a1d8f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
<link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f5a5d290-75b5-47c9-9d56-586f010a1d8f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_3274ad8a-9501-4db9-9637-28e7d1ec709a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
<link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_3274ad8a-9501-4db9-9637-28e7d1ec709a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_f8b0c397-4b61-49fe-ae12-992d009b4ec7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
<link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_f8b0c397-4b61-49fe-ae12-992d009b4ec7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_e70743b6-3193-4910-8342-394b735e08b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
<link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_e70743b6-3193-4910-8342-394b735e08b6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_18b1cb1d-aa35-43e3-98ee-3db5dba06065" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
<link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_18b1cb1d-aa35-43e3-98ee-3db5dba06065" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_a257287e-7049-4171-be7c-fc1743368f9d" xlink:href="opk-20201231.xsd#opk_IncreaseDecreaseinForeignCurrencyMeasurement"/>
<link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_opk_IncreaseDecreaseinForeignCurrencyMeasurement_a257287e-7049-4171-be7c-fc1743368f9d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6ffdcb6b-91d6-4d09-8bc1-7abdc14dcd8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
<link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6ffdcb6b-91d6-4d09-8bc1-7abdc14dcd8c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_90318b52-8bf9-42d0-9dc9-54e1ff333402" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
<link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a4ee3c5-2580-43d5-beda-981fe7c2cd59" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_90318b52-8bf9-42d0-9dc9-54e1ff333402" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa747c60-ab76-40ac-b37d-bcb8a644de94" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_ec98eb24-79d6-43bd-a35e-c7e8ec681d1f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireInvestments"/>
<link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa747c60-ab76-40ac-b37d-bcb8a644de94" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_ec98eb24-79d6-43bd-a35e-c7e8ec681d1f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_96989945-cc76-49e6-b4e1-26ce4f3308d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa747c60-ab76-40ac-b37d-bcb8a644de94" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_96989945-cc76-49e6-b4e1-26ce4f3308d2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_67920f0c-61ea-46f7-9e0a-959450536aa1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa747c60-ab76-40ac-b37d-bcb8a644de94" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_67920f0c-61ea-46f7-9e0a-959450536aa1" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_369e838e-a44b-4f71-ae7c-e5a5165c7a12" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
<link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa747c60-ab76-40ac-b37d-bcb8a644de94" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_369e838e-a44b-4f71-ae7c-e5a5165c7a12" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/BusinessandOrganization" xlink:type="simple" xlink:href="opk-20201231.xsd#BusinessandOrganization"/>
<link:calculationLink xlink:role="http://www.opko.com/role/BusinessandOrganization" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/BusinessandOrganizationNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#BusinessandOrganizationNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/BusinessandOrganizationNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ImpactofCOVID19" xlink:type="simple" xlink:href="opk-20201231.xsd#ImpactofCOVID19"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ImpactofCOVID19" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ImpactofCOVID19Details" xlink:type="simple" xlink:href="opk-20201231.xsd#ImpactofCOVID19Details"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ImpactofCOVID19Details" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="opk-20201231.xsd#SummaryofSignificantAccountingPolicies"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="opk-20201231.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#SummaryofSignificantAccountingPoliciesNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomelossPerShare" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomelossPerShare"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomelossPerShare" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomelossPerShareNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomelossPerShareNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomelossPerShareNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/Investments" xlink:type="simple" xlink:href="opk-20201231.xsd#Investments"/>
<link:calculationLink xlink:role="http://www.opko.com/role/Investments" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/InvestmentsTables" xlink:type="simple" xlink:href="opk-20201231.xsd#InvestmentsTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/InvestmentsTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/InvestmentsAccountingMethodCarryingValueandUnderlyingEquityinNetAssetsofUnconsolidatedInvestmentsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#InvestmentsAccountingMethodCarryingValueandUnderlyingEquityinNetAssetsofUnconsolidatedInvestmentsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/InvestmentsAccountingMethodCarryingValueandUnderlyingEquityinNetAssetsofUnconsolidatedInvestmentsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermInvestments"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_b09d1496-6085-4377-b8ce-3d75476d3c5b" xlink:href="opk-20201231.xsd#opk_EquityMethodInvestmentExcludingVariableInterestEntity"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:to="loc_opk_EquityMethodInvestmentExcludingVariableInterestEntity_b09d1496-6085-4377-b8ce-3d75476d3c5b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EquityMethodInvestmentVariableInterestEntity_12bf8174-63ae-4f68-b979-8933638de54a" xlink:href="opk-20201231.xsd#opk_EquityMethodInvestmentVariableInterestEntity"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:to="loc_opk_EquityMethodInvestmentVariableInterestEntity_12bf8174-63ae-4f68-b979-8933638de54a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_aa27648b-6033-4ef0-86c2-cb5476e15a5f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_aa27648b-6033-4ef0-86c2-cb5476e15a5f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_f60503b6-a1ed-4ce3-a63e-e2d1fd907924" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_f60503b6-a1ed-4ce3-a63e-e2d1fd907924" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_StockOptionandWarrantInvestments_0d25dab5-fad8-4daf-9950-bb0b0cdd7414" xlink:href="opk-20201231.xsd#opk_StockOptionandWarrantInvestments"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermInvestments_1bbf1264-cf59-4626-b70b-6ffcdfb61497" xlink:to="loc_opk_StockOptionandWarrantInvestments_0d25dab5-fad8-4daf-9950-bb0b0cdd7414" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/InvestmentsNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#InvestmentsNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/InvestmentsNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/InvestmentsScheduleofNetGainsandLossesonEquitySecuritiesDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#InvestmentsScheduleofNetGainsandLossesonEquitySecuritiesDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/InvestmentsScheduleofNetGainsandLossesonEquitySecuritiesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_eec539d4-9055-4d45-b723-25f9037561ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_f274046f-d445-4ddb-adcf-a1c548e52b21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_eec539d4-9055-4d45-b723-25f9037561ff" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_f274046f-d445-4ddb-adcf-a1c548e52b21" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_1ec8800d-0ca2-4764-a425-20c666d0698f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_eec539d4-9055-4d45-b723-25f9037561ff" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_1ec8800d-0ca2-4764-a425-20c666d0698f" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptions" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptions"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptions" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsTables" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptionsTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsCompositionofCertainFinancialStatementCaptionsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptionsCompositionofCertainFinancialStatementCaptionsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsCompositionofCertainFinancialStatementCaptionsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Supplies_451a2728-9d0e-4260-b4e3-f9efe9bd6fea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Supplies"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:to="loc_us-gaap_Supplies_451a2728-9d0e-4260-b4e3-f9efe9bd6fea" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_2b3a25b4-6cd6-4af8-9912-be5fd193dbf0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_2b3a25b4-6cd6-4af8-9912-be5fd193dbf0" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_TaxesRecoverableCurrent_449280db-7a55-4f6b-ab3e-03845e09c7c3" xlink:href="opk-20201231.xsd#opk_TaxesRecoverableCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:to="loc_opk_TaxesRecoverableCurrent_449280db-7a55-4f6b-ab3e-03845e09c7c3" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_f6aeedad-aa64-494b-b5b6-7976d60d2c84" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:to="loc_us-gaap_OtherAssetsCurrent_f6aeedad-aa64-494b-b5b6-7976d60d2c84" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_c44bcaa1-5388-4303-9346-c41b7593ff28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidInsurance"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6c64a3a5-86e6-4512-a981-89d36d69084e" xlink:to="loc_us-gaap_PrepaidInsurance_c44bcaa1-5388-4303-9346-c41b7593ff28" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_3b822a8a-b0e0-4401-a436-04579be2e79c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_3b822a8a-b0e0-4401-a436-04579be2e79c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_0828587f-f95e-47a7-89da-dfe5fad0d259" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_0828587f-f95e-47a7-89da-dfe5fad0d259" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_AccruedCommitmentsandContingenciesCurrent_1cdceda1-84a2-427c-825e-5751dd98abb9" xlink:href="opk-20201231.xsd#opk_AccruedCommitmentsandContingenciesCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_opk_AccruedCommitmentsandContingenciesCurrent_1cdceda1-84a2-427c-825e-5751dd98abb9" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_AccruedClinicalTrialsCurrent_e1e5b3b4-8fd4-4dd9-8ff3-7f10ed2d7b9a" xlink:href="opk-20201231.xsd#opk_AccruedClinicalTrialsCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_opk_AccruedClinicalTrialsCurrent_e1e5b3b4-8fd4-4dd9-8ff3-7f10ed2d7b9a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_21881b1c-a1ef-4b57-81be-2cefc63de7e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_21881b1c-a1ef-4b57-81be-2cefc63de7e5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_5f61159b-5203-4b17-b69b-a2b7190671c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_5f61159b-5203-4b17-b69b-a2b7190671c2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d4c7d219-72ee-43c3-8d8b-61741222f79b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d4c7d219-72ee-43c3-8d8b-61741222f79b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_edeeea55-4c68-4d2e-819a-eda6422fcdd5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
<link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_edeeea55-4c68-4d2e-819a-eda6422fcdd5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_InventoryReceivedNotInvoicedCurrent_40a47adf-867b-48f9-b1b2-d4f3afb6565f" xlink:href="opk-20201231.xsd#opk_InventoryReceivedNotInvoicedCurrent"/>
<link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_d8ddd433-4ec6-4b58-84de-99259d9a488b" xlink:to="loc_opk_InventoryReceivedNotInvoicedCurrent_40a47adf-867b-48f9-b1b2-d4f3afb6565f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e7c7122d-70a5-4bd3-b608-adc7eee93a24" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_279265f5-a36e-4d5d-8ac2-434d6bbc1ffb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_e7c7122d-70a5-4bd3-b608-adc7eee93a24" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_279265f5-a36e-4d5d-8ac2-434d6bbc1ffb" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_d69487ea-196d-4985-994e-d3da41973c3e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_e7c7122d-70a5-4bd3-b608-adc7eee93a24" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_d69487ea-196d-4985-994e-d3da41973c3e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_96f2fc65-98a7-4650-b6da-1f1d944565fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_e51e7f25-bb61-4062-bd43-290a39efe1ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_96f2fc65-98a7-4650-b6da-1f1d944565fd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_e51e7f25-bb61-4062-bd43-290a39efe1ac" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_8ca2fc8f-2f36-42db-b01e-d25f2a562ce8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_96f2fc65-98a7-4650-b6da-1f1d944565fd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_8ca2fc8f-2f36-42db-b01e-d25f2a562ce8" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_31f463d5-02b4-4ff7-86cc-1ba46c01ca17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0bceb01f-76ce-46e0-8bc6-97cf274224d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_31f463d5-02b4-4ff7-86cc-1ba46c01ca17" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0bceb01f-76ce-46e0-8bc6-97cf274224d4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_b61fe483-4867-4368-adae-18dabec13a76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_31f463d5-02b4-4ff7-86cc-1ba46c01ca17" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_b61fe483-4867-4368-adae-18dabec13a76" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInventorySupplies_17accfe0-5e4e-4d5e-99ab-1dcdfc06fe3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherInventorySupplies"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:to="loc_us-gaap_OtherInventorySupplies_17accfe0-5e4e-4d5e-99ab-1dcdfc06fe3f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_f59533cf-4af3-4776-b603-0b3872fcf2cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoods"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:to="loc_us-gaap_InventoryFinishedGoods_f59533cf-4af3-4776-b603-0b3872fcf2cd" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_81cf055d-4539-48bd-b992-a2c5438cc186" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:to="loc_us-gaap_InventoryWorkInProcess_81cf055d-4539-48bd-b992-a2c5438cc186" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_958c8e01-7628-4be0-8d2b-782d48f95065" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterials"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:to="loc_us-gaap_InventoryRawMaterials_958c8e01-7628-4be0-8d2b-782d48f95065" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_52652fdb-2c7d-4798-a8f4-bf0cfa0f20bb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryValuationReserves"/>
<link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_02b722ea-12ea-436e-bcff-beaf759169c9" xlink:to="loc_us-gaap_InventoryValuationReserves_52652fdb-2c7d-4798-a8f4-bf0cfa0f20bb" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_9e0fd49c-3a5c-42bf-8757-93f45b6feb50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_9e0fd49c-3a5c-42bf-8757-93f45b6feb50" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermLineOfCredit_271e10db-7cef-42d8-a477-486627365846" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermLineOfCredit"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_us-gaap_LongTermLineOfCredit_271e10db-7cef-42d8-a477-486627365846" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_e51d29a8-4ff0-4525-8977-ac5a1e1648d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_e51d29a8-4ff0-4525-8977-ac5a1e1648d5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_9a30594b-5149-4d5a-ad9d-6037a34134c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_9a30594b-5149-4d5a-ad9d-6037a34134c4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_MortgagesAndOtherDebtsPayable_d9121bbb-6e3c-4a84-9f06-102e06c2bdc7" xlink:href="opk-20201231.xsd#opk_MortgagesAndOtherDebtsPayable"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_opk_MortgagesAndOtherDebtsPayable_d9121bbb-6e3c-4a84-9f06-102e06c2bdc7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_2f9faac4-f920-4dbe-8006-8cb945ed19dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_e38e0a5b-843c-4079-9d73-e91763e219c5" xlink:to="loc_us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent_2f9faac4-f920-4dbe-8006-8cb945ed19dd" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptionsNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsSummaryofValuationAllowanceDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptionsSummaryofValuationAllowanceDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsSummaryofValuationAllowanceDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsChangesinGoodwillDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#CompositionofCertainFinancialStatementCaptionsChangesinGoodwillDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CompositionofCertainFinancialStatementCaptionsChangesinGoodwillDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/Debt" xlink:type="simple" xlink:href="opk-20201231.xsd#Debt"/>
<link:calculationLink xlink:role="http://www.opko.com/role/Debt" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DebtTables" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DebtScheduleofDebtDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtScheduleofDebtDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtScheduleofDebtDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DebtNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DebtScheduleofNotesDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtScheduleofNotesDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtScheduleofNotesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_35e389f9-7f99-42f8-b041-94c3c4ee803e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_94912463-87c3-47e7-90a2-740b11898f15" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_35e389f9-7f99-42f8-b041-94c3c4ee803e" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_94912463-87c3-47e7-90a2-740b11898f15" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_080b4595-d441-4690-8f2f-ebac3d5dc3ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_35e389f9-7f99-42f8-b041-94c3c4ee803e" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_080b4595-d441-4690-8f2f-ebac3d5dc3ff" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/DebtSummaryofLinesofCreditDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtSummaryofLinesofCreditDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtSummaryofLinesofCreditDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DebtMortgageNotesandOtherDebtDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DebtMortgageNotesandOtherDebtDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DebtMortgageNotesandOtherDebtDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_11a23634-f877-4a4e-b590-ff3dbde2e2f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_b75c316a-f729-4e35-b9ef-ea8f21d98942" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_11a23634-f877-4a4e-b590-ff3dbde2e2f6" xlink:to="loc_us-gaap_LongTermDebtCurrent_b75c316a-f729-4e35-b9ef-ea8f21d98942" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_5661adf2-6790-4760-911f-3f9dd6d4d133" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_11a23634-f877-4a4e-b590-ff3dbde2e2f6" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_5661adf2-6790-4760-911f-3f9dd6d4d133" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/ShareholdersEquity" xlink:type="simple" xlink:href="opk-20201231.xsd#ShareholdersEquity"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ShareholdersEquity" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/ShareholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#ShareholdersEquityNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/ShareholdersEquityNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLoss" xlink:type="simple" xlink:href="opk-20201231.xsd#AccumulatedOtherComprehensiveIncomeLoss"/>
<link:calculationLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLoss" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossTables" xlink:type="simple" xlink:href="opk-20201231.xsd#AccumulatedOtherComprehensiveIncomeLossTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossChangesinAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#AccumulatedOtherComprehensiveIncomeLossChangesinAccumulatedOtherComprehensiveIncomeNetofTaxDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/AccumulatedOtherComprehensiveIncomeLossChangesinAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EquityBasedCompensation" xlink:type="simple" xlink:href="opk-20201231.xsd#EquityBasedCompensation"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EquityBasedCompensation" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationTables" xlink:type="simple" xlink:href="opk-20201231.xsd#EquityBasedCompensationTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EquityBasedCompensationTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#EquityBasedCompensationNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EquityBasedCompensationNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationSummaryofOptionPricingFormulaDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#EquityBasedCompensationSummaryofOptionPricingFormulaDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EquityBasedCompensationSummaryofOptionPricingFormulaDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EquityBasedCompensationSummaryofOptionActivityDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#EquityBasedCompensationSummaryofOptionActivityDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EquityBasedCompensationSummaryofOptionActivityDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxes" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxes"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxes" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesComponentsofIncomeTaxBenefitProvisionDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesComponentsofIncomeTaxBenefitProvisionDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesComponentsofIncomeTaxBenefitProvisionDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_5c0f3ab9-fdfb-4f54-92b9-a8400fca0845" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_cb988d42-45f6-4456-9a48-21928aa96064" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_5c0f3ab9-fdfb-4f54-92b9-a8400fca0845" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_cb988d42-45f6-4456-9a48-21928aa96064" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_2148edeb-9d95-455e-ba9f-ddb2387eb024" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_5c0f3ab9-fdfb-4f54-92b9-a8400fca0845" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_2148edeb-9d95-455e-ba9f-ddb2387eb024" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_25549c59-c38c-47da-93ae-0e47a244aa11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_5c0f3ab9-fdfb-4f54-92b9-a8400fca0845" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_25549c59-c38c-47da-93ae-0e47a244aa11" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_9276957a-a579-4d7a-8db8-403eccf9d80e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_622f5a59-70d4-4a2e-bbe2-323274d3d72c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9276957a-a579-4d7a-8db8-403eccf9d80e" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_622f5a59-70d4-4a2e-bbe2-323274d3d72c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_1c0e6702-b533-4328-8658-4aa4fd2b4295" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9276957a-a579-4d7a-8db8-403eccf9d80e" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_1c0e6702-b533-4328-8658-4aa4fd2b4295" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_a9637b63-7139-47c9-8a5f-3b9876152559" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_844b9876-7751-41e6-9d16-cf46ef7a0ceb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_a9637b63-7139-47c9-8a5f-3b9876152559" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_844b9876-7751-41e6-9d16-cf46ef7a0ceb" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_102b65ea-9d0b-4eeb-bc78-78749f01b8c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_a9637b63-7139-47c9-8a5f-3b9876152559" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_102b65ea-9d0b-4eeb-bc78-78749f01b8c0" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_b43f7bc0-e54e-4d9f-8e7b-331cc1230539" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_a9637b63-7139-47c9-8a5f-3b9876152559" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_b43f7bc0-e54e-4d9f-8e7b-331cc1230539" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesComponentsofDeferredIncomeTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesComponentsofDeferredIncomeTaxAssetsandLiabilitiesDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesComponentsofDeferredIncomeTaxAssetsandLiabilitiesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_bd4b5e3a-f16d-4642-8b9e-b6def6a2b078" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_bd4b5e3a-f16d-4642-8b9e-b6def6a2b078" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_DeferredTaxLiabilitiesConvertibleDebt_274ee6e1-1cbb-4eb3-95f9-718e1a6f014b" xlink:href="opk-20201231.xsd#opk_DeferredTaxLiabilitiesConvertibleDebt"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:to="loc_opk_DeferredTaxLiabilitiesConvertibleDebt_274ee6e1-1cbb-4eb3-95f9-718e1a6f014b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_594638d7-2b8d-43d2-8cd5-26d082872839" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_594638d7-2b8d-43d2-8cd5-26d082872839" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_a5260658-b1a2-429f-b06c-925060290035" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_a5260658-b1a2-429f-b06c-925060290035" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_8bfc13b8-4c9e-4728-b621-f29f8bfc89f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_1b000ce2-237e-483b-af26-b7f820368a9d" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_8bfc13b8-4c9e-4728-b621-f29f8bfc89f6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance_a87c92fe-410b-457f-9c29-89cfc483a8a8" xlink:href="opk-20201231.xsd#opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_a77bff12-062b-44d0-a3ea-8325d559ff11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
<link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance_a87c92fe-410b-457f-9c29-89cfc483a8a8" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_a77bff12-062b-44d0-a3ea-8325d559ff11" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_8899b049-4464-4cd1-bc60-d2e6baf64a8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance_a87c92fe-410b-457f-9c29-89cfc483a8a8" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_8899b049-4464-4cd1-bc60-d2e6baf64a8c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_50ddc9a6-36e8-48b7-8536-2225ec277692" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_50ddc9a6-36e8-48b7-8536-2225ec277692" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_aba86e06-e69b-4295-9cbd-79c1047c1f99" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_aba86e06-e69b-4295-9cbd-79c1047c1f99" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsForeign_46603b05-3c6d-4b9c-bdac-d572e9844902" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsForeign"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsForeign_46603b05-3c6d-4b9c-bdac-d572e9844902" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_3594e792-05c8-43f9-8697-e2f0d396f77f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_3594e792-05c8-43f9-8697-e2f0d396f77f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_5402ba10-5b50-4546-abba-e85231871ca7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_5402ba10-5b50-4546-abba-e85231871ca7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_67a0a96b-48c0-4baf-b29f-194c2b6799bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_67a0a96b-48c0-4baf-b29f-194c2b6799bf" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_54c89d15-4f69-419c-ab72-e3e44319035f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_54c89d15-4f69-419c-ab72-e3e44319035f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_d78ce603-bf41-46bb-a721-ff55a1cd3544" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsEquityMethodInvestments"/>
<link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_d78ce603-bf41-46bb-a721-ff55a1cd3544" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_7fef4e4b-ccc3-4398-adb5-1d1e76756fb2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts"/>
<link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_7fef4e4b-ccc3-4398-adb5-1d1e76756fb2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_f56dbf08-1ffd-47fe-a8cc-7ab4a1a06969" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent"/>
<link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_f56dbf08-1ffd-47fe-a8cc-7ab4a1a06969" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsForeign_1b524979-a214-42d4-8522-7a2db4d9f096" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsForeign"/>
<link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsForeign_1b524979-a214-42d4-8522-7a2db4d9f096" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross_3e705a31-ff65-4bc2-bc23-f56b9ef24017" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross"/>
<link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross_3e705a31-ff65-4bc2-bc23-f56b9ef24017" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_DeferredTaxAssetsOperatingLeaseAsset_4907872f-51fa-4b9d-ba64-3851ceea6c4a" xlink:href="opk-20201231.xsd#opk_DeferredTaxAssetsOperatingLeaseAsset"/>
<link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_opk_DeferredTaxAssetsOperatingLeaseAsset_4907872f-51fa-4b9d-ba64-3851ceea6c4a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOtherTaxCarryforwards_06ff7ae3-897e-4afc-bfa8-b527969a237d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOtherTaxCarryforwards"/>
<link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_67fd43c5-b794-4718-b083-1a15f4885d7a" xlink:to="loc_us-gaap_DeferredTaxAssetsOtherTaxCarryforwards_06ff7ae3-897e-4afc-bfa8-b527969a237d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilities_b7df8c86-69bc-424b-b75b-0d3cf446e320" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_24f69aba-7c39-4597-aa95-3115fa31797e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_b7df8c86-69bc-424b-b75b-0d3cf446e320" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_24f69aba-7c39-4597-aa95-3115fa31797e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance_d5d32d20-f54b-460c-90da-e0ac1eab3941" xlink:href="opk-20201231.xsd#opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_b7df8c86-69bc-424b-b75b-0d3cf446e320" xlink:to="loc_opk_DeferredTaxLiabilitiesNetBeforeValuationAllowance_d5d32d20-f54b-460c-90da-e0ac1eab3941" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesChangeinGrossUnrecognizedIncomeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesChangeinGrossUnrecognizedIncomeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesChangeinGrossUnrecognizedIncomeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesScheduleofDifferenceinFederalandEffectiveTaxRateDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesScheduleofDifferenceinFederalandEffectiveTaxRateDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesScheduleofDifferenceinFederalandEffectiveTaxRateDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent_c1deb480-5628-4462-ab29-23dd0a247b67" xlink:href="opk-20201231.xsd#opk_EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_opk_EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent_c1deb480-5628-4462-ab29-23dd0a247b67" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent_0ce5e1ca-e6a1-42c7-9904-ce0695416b9b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent_0ce5e1ca-e6a1-42c7-9904-ce0695416b9b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_6e066121-38d7-4878-a547-ba5e9eaffa31" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_6e066121-38d7-4878-a547-ba5e9eaffa31" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_a0f9a9d6-29e7-49b8-9087-0120491c3f53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_a0f9a9d6-29e7-49b8-9087-0120491c3f53" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_fd715504-cd3a-406a-9d6b-5df4f0efffd7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_fd715504-cd3a-406a-9d6b-5df4f0efffd7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EffectiveIncomeTaxRateReconciliationImputedInterestPercent_ad2e8780-59dc-4001-84f4-b7de12133f02" xlink:href="opk-20201231.xsd#opk_EffectiveIncomeTaxRateReconciliationImputedInterestPercent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_opk_EffectiveIncomeTaxRateReconciliationImputedInterestPercent_ad2e8780-59dc-4001-84f4-b7de12133f02" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_e1be6224-39ab-4fa5-a01e-9a4289ff82e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_e1be6224-39ab-4fa5-a01e-9a4289ff82e7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_246ae1f3-ac3a-49ca-92d8-15254de08fde" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
<link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_246ae1f3-ac3a-49ca-92d8-15254de08fde" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_7105823a-6852-47e4-b0f6-409d79fdd414" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate"/>
<link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_7105823a-6852-47e4-b0f6-409d79fdd414" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_6a3615d0-ac72-479e-8e53-bdc11040dc42" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
<link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_6a3615d0-ac72-479e-8e53-bdc11040dc42" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInProcessResearchAndDevelopmentPercent_3cfdf602-bf01-474e-9c86-cbda703050f5" xlink:href="opk-20201231.xsd#opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInProcessResearchAndDevelopmentPercent"/>
<link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInProcessResearchAndDevelopmentPercent_3cfdf602-bf01-474e-9c86-cbda703050f5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseConvertibleDebt_5c339b33-c011-4773-abca-b711697c0bc1" xlink:href="opk-20201231.xsd#opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseConvertibleDebt"/>
<link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_opk_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseConvertibleDebt_5c339b33-c011-4773-abca-b711697c0bc1" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent_618670e8-cfcc-4735-895d-ad7d075c7c4a" xlink:href="opk-20201231.xsd#opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent"/>
<link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent_618670e8-cfcc-4735-895d-ad7d075c7c4a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_0d4547ea-7be8-49df-a2af-c84dd2942ad6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
<link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_0d4547ea-7be8-49df-a2af-c84dd2942ad6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_ecea4901-a090-4eca-b7c6-e14c878e7485" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
<link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_5edb07ee-3e75-410d-a6f6-e058b26fcf3f" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_ecea4901-a090-4eca-b7c6-e14c878e7485" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/IncomeTaxesReconciliationLossesBeforeTaxUSandForeignJurisdictionsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#IncomeTaxesReconciliationLossesBeforeTaxUSandForeignJurisdictionsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/IncomeTaxesReconciliationLossesBeforeTaxUSandForeignJurisdictionsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments_21609e57-166a-45a8-8dbe-ba3af89610df" xlink:href="opk-20201231.xsd#opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_11ed4f6c-013c-4da8-a91d-ad3d3809ea94" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments_21609e57-166a-45a8-8dbe-ba3af89610df" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_11ed4f6c-013c-4da8-a91d-ad3d3809ea94" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_51138e95-7132-4c85-a572-7e9ac8d6f047" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments_21609e57-166a-45a8-8dbe-ba3af89610df" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_51138e95-7132-4c85-a572-7e9ac8d6f047" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="opk-20201231.xsd#RelatedPartyTransactions"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RelatedPartyTransactions" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#RelatedPartyTransactionsNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EmployeeBenefitPlans" xlink:type="simple" xlink:href="opk-20201231.xsd#EmployeeBenefitPlans"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EmployeeBenefitPlans" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/EmployeeBenefitPlansNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#EmployeeBenefitPlansNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/EmployeeBenefitPlansNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="opk-20201231.xsd#CommitmentsandContingencies"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CommitmentsandContingencies" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#CommitmentsandContingenciesNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognition" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognition"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognition" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognitionTables" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognitionTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognitionTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognitionNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognitionNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognitionNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognitionScheduleofDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognitionScheduleofDisaggregationofRevenueDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognitionScheduleofDisaggregationofRevenueDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognitionScheduleofProductSalesAllowancesandAccrualsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognitionScheduleofProductSalesAllowancesandAccrualsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognitionScheduleofProductSalesAllowancesandAccrualsDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/RevenueRecognitionChangesinContractualLiabilitiesBalanceDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#RevenueRecognitionChangesinContractualLiabilitiesBalanceDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/RevenueRecognitionChangesinContractualLiabilitiesBalanceDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/StrategicAlliances" xlink:type="simple" xlink:href="opk-20201231.xsd#StrategicAlliances"/>
<link:calculationLink xlink:role="http://www.opko.com/role/StrategicAlliances" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/StrategicAlliancesNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#StrategicAlliancesNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/StrategicAlliancesNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/Leases" xlink:type="simple" xlink:href="opk-20201231.xsd#Leases"/>
<link:calculationLink xlink:role="http://www.opko.com/role/Leases" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/LeasesTables" xlink:type="simple" xlink:href="opk-20201231.xsd#LeasesTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/LeasesTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/LeasesLeaseAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#LeasesLeaseAssetsandLiabilitiesDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/LeasesLeaseAssetsandLiabilitiesDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/LeasesLeaseLiabilityMaturityDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#LeasesLeaseLiabilityMaturityDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/LeasesLeaseLiabilityMaturityDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3401b2da-c022-455c-a22a-a7f6d8ea5940" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3401b2da-c022-455c-a22a-a7f6d8ea5940" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c8d1192a-501c-496e-80ba-0b5fa1008155" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c8d1192a-501c-496e-80ba-0b5fa1008155" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2465444b-36b1-43ea-8b33-8047acb040d8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2465444b-36b1-43ea-8b33-8047acb040d8" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_772da83d-6862-4425-a6bf-e677f16e8bc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_772da83d-6862-4425-a6bf-e677f16e8bc4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_dd2f7eaa-2ce9-4000-8b74-768bcdb3e4b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_dd2f7eaa-2ce9-4000-8b74-768bcdb3e4b4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_da298c57-524b-44fd-8727-d675170ea2a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_be99db23-c3a1-43e3-bbd4-d942d9177c85" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_da298c57-524b-44fd-8727-d675170ea2a4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_b4b29f56-6262-4f1d-8a98-14aff4a93732" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_b4b29f56-6262-4f1d-8a98-14aff4a93732" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_1f8aa2c7-cfa8-421f-baee-98add7d04a47" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_1f8aa2c7-cfa8-421f-baee-98add7d04a47" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_50f37fb2-acf6-48ea-92fd-37c40de90ec8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_50f37fb2-acf6-48ea-92fd-37c40de90ec8" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_cfde08aa-60c8-4bc5-b60c-0a0bacf99c1d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_cfde08aa-60c8-4bc5-b60c-0a0bacf99c1d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_0eac944b-0038-43c8-86ad-8142f164bc10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_0eac944b-0038-43c8-86ad-8142f164bc10" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_7a9f591b-c960-436c-a118-d23047285e52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_82d7d75c-947f-4b31-8aff-731124065821" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_7a9f591b-c960-436c-a118-d23047285e52" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#LeasesNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/LeasesNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#LeasesSupplementalCashFlowInformationDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_opk_PaymentsForLeases_789af007-5482-46e3-ad2a-4cfe04ef27d7" xlink:href="opk-20201231.xsd#opk_PaymentsForLeases"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_0ee057d2-fd8c-4e09-a96f-250276f878eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasePayments"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_PaymentsForLeases_789af007-5482-46e3-ad2a-4cfe04ef27d7" xlink:to="loc_us-gaap_OperatingLeasePayments_0ee057d2-fd8c-4e09-a96f-250276f878eb" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_39ed681a-e2ac-41a9-a6f4-097392f50dc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseInterestPaymentOnLiability"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_PaymentsForLeases_789af007-5482-46e3-ad2a-4cfe04ef27d7" xlink:to="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_39ed681a-e2ac-41a9-a6f4-097392f50dc4" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_7726cb4a-c0d6-4f26-8a87-101d6d5165c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_opk_PaymentsForLeases_789af007-5482-46e3-ad2a-4cfe04ef27d7" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_7726cb4a-c0d6-4f26-8a87-101d6d5165c6" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/Segments" xlink:type="simple" xlink:href="opk-20201231.xsd#Segments"/>
<link:calculationLink xlink:role="http://www.opko.com/role/Segments" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SegmentsTables" xlink:type="simple" xlink:href="opk-20201231.xsd#SegmentsTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SegmentsTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SegmentsNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#SegmentsNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SegmentsNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SegmentsOperationsandAssetsforOperatingSegmentsandGeographicInformationDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#SegmentsOperationsandAssetsforOperatingSegmentsandGeographicInformationDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SegmentsOperationsandAssetsforOperatingSegmentsandGeographicInformationDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SegmentsPropertyPlantandEquipmentNetbyJurisdictionDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#SegmentsPropertyPlantandEquipmentNetbyJurisdictionDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SegmentsPropertyPlantandEquipmentNetbyJurisdictionDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurements"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurements" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurementsTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_e9b1ff41-bd27-4f10-bd70-baae466866a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_884bc7aa-0aa6-4660-acaa-991380692f26" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_e9b1ff41-bd27-4f10-bd70-baae466866a4" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_884bc7aa-0aa6-4660-acaa-991380692f26" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_b1b3c108-1962-44a8-a274-0770b748f778" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_e9b1ff41-bd27-4f10-bd70-baae466866a4" xlink:to="loc_us-gaap_DerivativeLiabilities_b1b3c108-1962-44a8-a274-0770b748f778" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_290ed575-f712-4234-9138-484684ed0e20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_a54ee772-40f3-4250-b6fe-aee7dd6e7253" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_290ed575-f712-4234-9138-484684ed0e20" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_a54ee772-40f3-4250-b6fe-aee7dd6e7253" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_9418f19a-0082-4477-a30b-0545bbace4c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_290ed575-f712-4234-9138-484684ed0e20" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_9418f19a-0082-4477-a30b-0545bbace4c7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_ff90edd0-e9d5-469e-bb3c-de7d0a91c032" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_290ed575-f712-4234-9138-484684ed0e20" xlink:to="loc_us-gaap_DerivativeAssets_ff90edd0-e9d5-469e-bb3c-de7d0a91c032" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsCarryingAmountandEstimatedFairValueofLongTermDebtDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurementsCarryingAmountandEstimatedFairValueofLongTermDebtDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurementsCarryingAmountandEstimatedFairValueofLongTermDebtDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsReconciliationofBeginningandEndingBalancesofLevel3AssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurementsReconciliationofBeginningandEndingBalancesofLevel3AssetsandLiabilitiesDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurementsReconciliationofBeginningandEndingBalancesofLevel3AssetsandLiabilitiesDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#FairValueMeasurementsNarrativeDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DerivativeContracts" xlink:type="simple" xlink:href="opk-20201231.xsd#DerivativeContracts"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DerivativeContracts" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DerivativeContractsTables" xlink:type="simple" xlink:href="opk-20201231.xsd#DerivativeContractsTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DerivativeContractsTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DerivativeContractsSummaryofFairValuesandPresentationofDerivativeFinancialInstrumentsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DerivativeContractsSummaryofFairValuesandPresentationofDerivativeFinancialInstrumentsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DerivativeContractsSummaryofFairValuesandPresentationofDerivativeFinancialInstrumentsDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/DerivativeContractsSummaryoftheLossesandGainsRecordedfortheChangesinFairValuesofDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#DerivativeContractsSummaryoftheLossesandGainsRecordedfortheChangesinFairValuesofDerivativeInstrumentsDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/DerivativeContractsSummaryoftheLossesandGainsRecordedfortheChangesinFairValuesofDerivativeInstrumentsDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:type="simple" xlink:href="opk-20201231.xsd#SelectedQuarterlyFinancialDataUnaudited"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="simple" xlink:href="opk-20201231.xsd#SelectedQuarterlyFinancialDataUnauditedTables"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedSummaryofSelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="simple" xlink:href="opk-20201231.xsd#SelectedQuarterlyFinancialDataUnauditedSummaryofSelectedQuarterlyFinancialDataUnauditedDetails"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SelectedQuarterlyFinancialDataUnauditedSummaryofSelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="extended"/>
<link:roleRef roleURI="http://www.opko.com/role/SubsequentEvents" xlink:type="simple" xlink:href="opk-20201231.xsd#SubsequentEvents"/>
<link:calculationLink xlink:role="http://www.opko.com/role/SubsequentEvents" xlink:type="extended"/>
</link:linkbase>

4 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/01/24  Opko Health, Inc.                 10-K       12/31/23  122:18M                                    RDG Filings/FA
 5/15/23  Opko Health, Inc.                 S-8         5/15/23    4:98K                                    RDG Filings/FA
 2/27/23  Opko Health, Inc.                 10-K       12/31/22  121:20M
 3/01/22  Opko Health, Inc.                 10-K       12/31/21  110:16M

46 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 7/31/20  Opko Health, Inc.                 10-Q        6/30/20   83:13M
 3/02/20  Opko Health, Inc.                 10-K       12/31/19  111:16M
11/05/19  Opko Health, Inc.                 10-Q        9/30/19   82:10M
10/29/19  Opko Health, Inc.                 8-K®:1,9   10/24/19   12:415K                                   Donnelley … Solutions/FA
 6/21/19  Opko Health, Inc.                 8-K:5,7,9   6/20/19    2:88K
 5/08/19  Opko Health, Inc.                 10-Q        3/31/19   82:9.6M
 3/01/19  Opko Health, Inc.                 10-K       12/31/18  112:17M
 2/07/19  Opko Health, Inc.                 8-K:1,2,3,9 2/04/19    7:1.1M                                   Donnelley … Solutions/FA
 8/07/18  Opko Health, Inc.                 10-Q        6/30/18   77:9.3M
 3/01/18  Opko Health, Inc.                 10-K       12/31/17  111:16M
11/08/17  Opko Health, Inc.                 10-Q        9/30/17   75:8.9M
10/12/17  Opko Health, Inc.                 8-K:1,9    10/12/17    2:34K                                    Donnelley … Solutions/FA
 3/23/17  Opko Health, Inc.                 8-K:1,2,9   3/17/17    2:52K                                    Donnelley … Solutions/FA
 8/08/16  Opko Health, Inc.                 10-Q        6/30/16   80:10M
 6/30/16  Opko Health, Inc.                 8-K:1,3,7,9 6/29/16    3:580K                                   Donnelley … Solutions/FA
 3/25/16  Opko Health, Inc.                 DEF 14A     5/05/16    1:498K                                   Donnelley … Solutions/FA
 2/29/16  Opko Health, Inc.                 10-K       12/31/15  116:17M
 8/05/15  Opko Health, Inc.                 10-Q        6/30/15   80:10M
 6/04/15  Opko Health, Inc.                 8-K:1,7,9   6/03/15    3:712K                                   Donnelley … Solutions/FA
 2/27/15  Opko Health, Inc.                 10-K       12/31/14  109:23M
11/12/13  Opko Health, Inc.                 10-Q        9/30/13   76:14M
 6/27/13  Opko Health, Inc.                 S-4                    6:3M                                     Donnelley … Solutions/FA
 5/10/13  Opko Health, Inc.                 10-Q        3/31/13   76:9.1M                                   Donnelley … Solutions/FA
 3/22/13  Opko Health, Inc.                 SC 13D                 2:350K Phio Pharmaceuticals Corp.        Donnelley … Solutions/FA
 3/18/13  Opko Health, Inc.                 10-K       12/31/12  111:15M                                    Donnelley … Solutions/FA
 2/05/13  Opko Health, Inc.                 8-K:1,2,3,8 1/30/13    3:751K                                   Donnelley … Solutions/FA
 1/29/13  Opko Health, Inc.                 8-K:1,2,3,8 1/23/13    4:331K                                   Donnelley … Solutions/FA
11/09/12  Opko Health, Inc.                 10-Q        9/30/12   60:6.7M                                   Donnelley … Solutions/FA
 5/10/12  Opko Health, Inc.                 10-Q        3/31/12   33:2.5M                                   Donnelley … Solutions/FA
 3/15/12  Opko Health, Inc.                 10-K       12/31/11   45:5.5M                                   Donnelley … Solutions/FA
11/09/11  Opko Health, Inc.                 10-Q        9/30/11   34:2.7M                                   Donnelley … Solutions/FA
 7/28/11  Opko Health, Inc.                 10-K/A     12/31/10    4:393K                                   Donnelley … Solutions/FA
 7/05/11  Opko Health, Inc.                 10-Q/A      3/31/11    4:164K                                   Donnelley … Solutions/FA
 5/10/11  Opko Health, Inc.                 10-Q        3/31/11    8:488K                                   Donnelley … Solutions/FA
 3/10/11  Opko Health, Inc.                 8-K:1,7,9   3/09/11    4:215K                                   Donnelley … Solutions/FA
 2/03/11  Opko Health, Inc.                 10-K/A     12/31/09    7:1M                                     Donnelley … Solutions/FA
 5/10/10  Opko Health, Inc.                 10-Q        3/31/10    6:396K                                   Donnelley … Solutions/FA
 3/17/10  Opko Health, Inc.                 10-K       12/31/09    9:1.1M                                   Donnelley … Solutions/FA
11/09/09  Opko Health, Inc.                 10-Q        9/30/09    7:373K                                   Donnelley … Solutions/FA
 9/24/09  Opko Health, Inc.                 8-K:1,3,5,8 9/18/09    6:2.7M                                   Donnelley … Solutions/FA
 8/07/09  Opko Health, Inc.                 10-Q        6/30/09    7:332K                                   Donnelley … Solutions/FA
 5/08/09  Opko Health, Inc.                 10-Q        3/31/09    7:237K                                   Bowne of Atlanta Inc./FA
11/12/08  Opko Health, Inc.                 10-Q        9/30/08    6:269K                                   Bowne of Atlanta Inc./FA
 8/08/08  Opko Health, Inc.                 10-Q        6/30/08    8:1M                                     Toppan Merrill/FA
 3/31/08  Opko Health, Inc.                 10-K       12/31/07   13:2.7M                                   Toppan Merrill/FA
 4/02/07  Opko Health, Inc.                 8-K:1,2,3,5 3/27/07   20:2M                                     Bowne of Atlanta Inc./FA
↑Top
Filing Submission 0000944809-21-000015   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Sun., Apr. 28, 2:27:43.1am ET