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Opko Health, Inc. – ‘10-K’ for 12/31/22 – ‘EX-101.SCH’

On:  Monday, 2/27/23, at 4:59pm ET   ·   For:  12/31/22   ·   Accession #:  944809-23-13   ·   File #:  1-33528

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  As Of               Filer                 Filing    For·On·As Docs:Size

 2/27/23  Opko Health, Inc.                 10-K       12/31/22  121:20M

Annual Report   —   Form 10-K

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   4.18M 
 2: EX-10.22    Material Contract                                   HTML    102K 
 3: EX-21.0     Subsidiaries List                                   HTML     35K 
 4: EX-23.1     Consent of Expert or Counsel                        HTML     33K 
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     35K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     35K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     32K 
 8: EX-32.2     Certification -- §906 - SOA'02                      HTML     32K 
14: R1          Cover                                               HTML     94K 
15: R2          Audit Information                                   HTML     36K 
16: R3          Consolidated Balance Sheets                         HTML    160K 
17: R4          Consolidated Balance Sheets (Parenthetical)         HTML     37K 
18: R5          Consolidated Statements of Operations               HTML    123K 
19: R6          Consolidated Statements of Comprehensive Income     HTML     54K 
                (Loss)                                                           
20: R7          Consolidated Statements of Equity                   HTML    120K 
21: R8          Consolidated Statements of Cash Flows               HTML    157K 
22: R9          Business and Organization                           HTML     46K 
23: R10         Impact of COVID-19 and foreign exchange rates       HTML     37K 
24: R11         Summary of Significant Accounting Policies          HTML     69K 
25: R12         Income (loss) Per Share                             HTML     37K 
26: R13         Acquisitions and Investments                        HTML     79K 
27: R14         Composition of Certain Financial Statement          HTML    170K 
                Captions                                                         
28: R15         Debt                                                HTML    123K 
29: R16         Shareholders' Equity                                HTML     41K 
30: R17         Accumulated Other Comprehensive Income (Loss)       HTML     43K 
31: R18         Equity-Based Compensation                           HTML     76K 
32: R19         Income Taxes                                        HTML    144K 
33: R20         Related Party Transactions                          HTML     41K 
34: R21         Employee Benefit Plans                              HTML     37K 
35: R22         Commitments and Contingencies                       HTML     49K 
36: R23         Revenue Recognition                                 HTML    124K 
37: R24         Strategic Alliances                                 HTML     56K 
38: R25         Leases                                              HTML    120K 
39: R26         Segments                                            HTML    114K 
40: R27         Fair Value Measurements                             HTML    100K 
41: R28         Derivative Contracts                                HTML     52K 
42: R29         Selected Quarterly Financial Data (Unaudited)       HTML     57K 
43: R30         Subsequent Events                                   HTML     36K 
44: R31         Schedule I - Condensed Financial Information of     HTML    209K 
                Registrant                                                       
45: R32         Summary of Significant Accounting Policies          HTML    121K 
                (Policies)                                                       
46: R33         Acquisitions and Investments (Tables)               HTML     69K 
47: R34         Composition of Certain Financial Statement          HTML    175K 
                Captions (Tables)                                                
48: R35         Debt (Tables)                                       HTML    106K 
49: R36         Accumulated Other Comprehensive Income (Loss)       HTML     43K 
                (Tables)                                                         
50: R37         Equity-Based Compensation (Tables)                  HTML     72K 
51: R38         Income Taxes (Tables)                               HTML    139K 
52: R39         Revenue Recognition (Tables)                        HTML    101K 
53: R40         Leases (Tables)                                     HTML     90K 
54: R41         Segments (Tables)                                   HTML    112K 
55: R42         Fair Value Measurements (Tables)                    HTML    116K 
56: R43         Derivative Contracts (Tables)                       HTML     53K 
57: R44         Selected Quarterly Financial Data (Unaudited)       HTML     57K 
                (Tables)                                                         
58: R45         Business and Organization (Details)                 HTML    104K 
59: R46         Impact of COVID-19 and foreign exchange rates       HTML     56K 
                (Details)                                                        
60: R47         Summary of Significant Accounting Policies          HTML    166K 
                (Details)                                                        
61: R48         Income (loss) Per Share (Details)                   HTML     46K 
62: R49         Acquisitions and Investments - Narrative (Details)  HTML    216K 
63: R50         Acquisitions and Investments - Schedule of          HTML     58K 
                Preliminary Purchase Price Allocation and                        
                Estimated Fair Value of Assets Acquired and                      
                Liabilities Assumed (Details)                                    
64: R51         Acquisitions and Investments - Accounting Method,   HTML     51K 
                Carrying Value and Underlying Equity in Net Assets               
                of Unconsolidated Investments (Details)                          
65: R52         Acquisitions and Investments - Schedule of Net      HTML     38K 
                Gains and Losses on Equity Securities (Details)                  
66: R53         Composition of Certain Financial Statement          HTML    157K 
                Captions - Composition of Certain Financial                      
                Statement Captions (Details)                                     
67: R54         Composition of Certain Financial Statement          HTML     75K 
                Captions - Narrative (Details)                                   
68: R55         Composition of Certain Financial Statement          HTML     49K 
                Captions - Summary of Valuation Allowance                        
                (Details)                                                        
69: R56         Composition of Certain Financial Statement          HTML     97K 
                Captions - Changes in Goodwill (Details)                         
70: R57         Debt - Schedule of Debt (Details)                   HTML     62K 
71: R58         Debt - Narrative (Details)                          HTML    242K 
72: R59         Debt - Schedule of Notes (Details)                  HTML     68K 
73: R60         Debt - Summary of Lines of Credit (Details)         HTML     77K 
74: R61         Debt - Mortgage Notes and Other Debt (Details)      HTML     41K 
75: R62         Shareholders' Equity (Details)                      HTML     56K 
76: R63         Accumulated Other Comprehensive Income (Loss) -     HTML     42K 
                Changes in Accumulated Other Comprehensive Income,               
                Net of Tax (Details)                                             
77: R64         Equity-Based Compensation - Narrative (Details)     HTML     90K 
78: R65         Equity-Based Compensation - Summary of              HTML     49K 
                Option-Pricing Formula (Details)                                 
79: R66         Equity-Based Compensation - Summary of Option       HTML     86K 
                Activity (Details)                                               
80: R67         Equity-Based Compensation - Summary of Restricted   HTML     56K 
                Stock Unit Activity (Details)                                    
81: R68         Income Taxes - Components of Income Tax Benefit     HTML     60K 
                (Provision) (Details)                                            
82: R69         Income Taxes - Components of Deferred Income Tax    HTML     93K 
                Assets and Liabilities (Details)                                 
83: R70         Income Taxes - Narrative (Details)                  HTML     68K 
84: R71         Income Taxes - Change in Gross Unrecognized Income  HTML     43K 
                (Details)                                                        
85: R72         Income Taxes - Schedule of Difference in Federal    HTML     73K 
                and Effective Tax Rate (Details)                                 
86: R73         Income Taxes - Reconciliation Losses Before Tax,    HTML     39K 
                US and Foreign Jurisdictions (Details)                           
87: R74         Related Party Transactions (Details)                HTML    134K 
88: R75         Employee Benefit Plans (Details)                    HTML     40K 
89: R76         Commitments and Contingencies (Details)             HTML     67K 
90: R77         Revenue Recognition - Narrative (Details)           HTML     91K 
91: R78         Revenue Recognition - Schedule of Disaggregation    HTML     53K 
                of Revenue (Details)                                             
92: R79         Revenue Recognition - Schedule of Product Sales     HTML     68K 
                Allowances and Accruals (Details)                                
93: R80         Revenue Recognition - Changes in Contractual        HTML     36K 
                Liabilities Balance (Details)                                    
94: R81         Strategic Alliances (Details)                       HTML    180K 
95: R82         Leases - Lease Assets and Liabilities (Details)     HTML     66K 
96: R83         Leases - Lease Liability Maturity (Details)         HTML     71K 
97: R84         Leases - Narrative (Details)                        HTML     38K 
98: R85         Leases - Lease Cash Flow Information (Details)      HTML     39K 
99: R86         Segments - Narrative (Details)                      HTML     47K 
100: R87         Segments - Operations and Assets for Operating      HTML    132K  
                Segments and Geographic Information (Details)                    
101: R88         Segments - Property, Plant and Equipment, Net by    HTML     38K  
                Jurisdiction (Details)                                           
102: R89         Fair Value Measurements - Financial Assets and      HTML     77K  
                Liabilities Measured at Fair Value on a Recurring                
                Basis (Details)                                                  
103: R90         Fair Value Measurements - Carrying Amount and       HTML     43K  
                Estimated Fair Value of Long-Term Debt (Details)                 
104: R91         Fair Value Measurements - Reconciliation of         HTML     44K  
                Beginning and Ending Balances of Level 3 Assets                  
                and Liabilities (Details)                                        
105: R92         Fair Value Measurements - Narrative (Details)       HTML     38K  
106: R93         Derivative Contracts - Balance Sheet Component      HTML     42K  
                (Details)                                                        
107: R94         Derivative Contracts - Derivative Gains (Losses)    HTML     39K  
                (Details)                                                        
108: R95         Selected Quarterly Financial Data (Unaudited) -     HTML     66K  
                Summary of Selected Quarterly Financial Data                     
                (Unaudited) (Details)                                            
109: R96         Subsequent Events (Details)                         HTML     77K  
110: R97         Schedule I - Condensed Financial Information of     HTML    161K  
                Registrant - Parent Company Condensed Balance                    
                Sheets (Details)                                                 
111: R98         Schedule I - Condensed Financial Information of     HTML    124K  
                Registrant - Parent Company Condensed Statements                 
                of Income (Details)                                              
112: R99         Schedule I - Condensed Financial Information of     HTML     59K  
                Registrant - Parent Company Condensed Statements                 
                of Comprehensive Income (Details)                                
113: R100        Schedule I - Condensed Financial Information of     HTML    147K  
                Registrant - Parent Company Condensed Statements                 
                of Cash Flows (Details)                                          
114: R101        Schedule I - Condensed Financial Information of     HTML    373K  
                Registrant - Narrative (Details)                                 
115: R102        Schedule I - Condensed Financial Information of     HTML     81K  
                Registrant - Schedule of Notes (Details)                         
116: R9999       Uncategorized Items - opk-20221231.htm              HTML     51K  
119: XML         IDEA XML File -- Filing Summary                      XML    223K  
117: XML         XBRL Instance -- opk-20221231_htm                    XML   4.99M  
118: EXCEL       IDEA Workbook of Financial Reports                  XLSX    360K  
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13: EX-101.PRE  XBRL Presentations -- opk-20221231_pre               XML   2.35M 
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120: JSON        XBRL Instance as JSON Data -- MetaLinks              809±  1.27M  
121: ZIP         XBRL Zipped Folder -- 0000944809-23-000013-xbrl      Zip   1.09M

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<link:definition> 0000030 - Disclosure - Subsequent Events </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0000031 - Disclosure - Schedule I - Condensed Financial Information of Registrant </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0000032 - Disclosure - Summary of Significant Accounting Policies (Policies) </link:definition>
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<link:definition> 0000033 - Disclosure - Acquisitions and Investments (Tables) </link:definition>
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<link:definition> 0000034 - Disclosure - Composition of Certain Financial Statement Captions (Tables) </link:definition>
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<link:definition> 0000035 - Disclosure - Debt (Tables) </link:definition>
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<link:definition> 0000036 - Disclosure - Accumulated Other Comprehensive Income (Loss) (Tables) </link:definition>
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<link:definition> 0000037 - Disclosure - Equity-Based Compensation (Tables) </link:definition>
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<link:definition> 0000038 - Disclosure - Income Taxes (Tables) </link:definition>
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<link:definition> 0000039 - Disclosure - Revenue Recognition (Tables) </link:definition>
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<link:definition> 0000040 - Disclosure - Leases (Tables) </link:definition>
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<link:definition> 0000041 - Disclosure - Segments (Tables) </link:definition>
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<link:definition> 0000042 - Disclosure - Fair Value Measurements (Tables) </link:definition>
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<link:definition> 0000045 - Disclosure - Business and Organization (Details) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0000046 - Disclosure - Impact of COVID-19 and foreign exchange rates (Details) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0000048 - Disclosure - Income (loss) Per Share (Details) </link:definition>
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<link:definition> 0000056 - Disclosure - Composition of Certain Financial Statement Captions - Changes in Goodwill (Details) </link:definition>
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<link:definition> 0000057 - Disclosure - Debt - Schedule of Debt (Details) </link:definition>
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<link:definition> 0000058 - Disclosure - Debt - Narrative (Details) </link:definition>
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<link:definition> 0000060 - Disclosure - Debt - Summary of Lines of Credit (Details) </link:definition>
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<link:definition> 0000061 - Disclosure - Debt - Mortgage Notes and Other Debt (Details) </link:definition>
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<link:definition> 0000062 - Disclosure - Shareholders' Equity (Details) </link:definition>
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<link:definition> 0000068 - Disclosure - Income Taxes - Components of Income Tax Benefit (Provision) (Details) </link:definition>
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<link:definition> 0000069 - Disclosure - Income Taxes - Components of Deferred Income Tax Assets and Liabilities (Details) </link:definition>
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<link:definition> 0000071 - Disclosure - Income Taxes - Change in Gross Unrecognized Income (Details) </link:definition>
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<link:definition> 0000072 - Disclosure - Income Taxes - Schedule of Difference in Federal and Effective Tax Rate (Details) </link:definition>
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<link:definition> 0000075 - Disclosure - Employee Benefit Plans (Details) </link:definition>
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<link:definition> 0000078 - Disclosure - Revenue Recognition - Schedule of Disaggregation of Revenue (Details) </link:definition>
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<link:definition> 0000079 - Disclosure - Revenue Recognition - Schedule of Product Sales Allowances and Accruals (Details) </link:definition>
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<link:definition> 0000080 - Disclosure - Revenue Recognition - Changes in Contractual Liabilities Balance (Details) </link:definition>
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<link:definition> 0000081 - Disclosure - Strategic Alliances (Details) </link:definition>
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<link:definition> 0000083 - Disclosure - Leases - Lease Liability Maturity (Details) </link:definition>
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<link:definition> 0000085 - Disclosure - Leases - Lease Cash Flow Information (Details) </link:definition>
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<xs:element id="opk_CollaborativeArrangementSalesMilestonePayment" abstract="false" name="CollaborativeArrangementSalesMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_InCellDxInc.Member" abstract="true" name="InCellDxInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_CorpbancaMember" abstract="true" name="CorpbancaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_BusinessAcquisitionOutstandingSharesHeldPercentage" abstract="false" name="BusinessAcquisitionOutstandingSharesHeldPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="opk_ConvertibleSeniorNotesDue2025Member" abstract="true" name="ConvertibleSeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ModigeneIncPlanMember" abstract="true" name="ModigeneIncPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_GeneDxHoldingsMember" abstract="true" name="GeneDxHoldingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_LeaderMedMember" abstract="true" name="LeaderMedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_EloxxPharmaceuticalsMember" abstract="true" name="EloxxPharmaceuticalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_AdoptionOfASC326AndOther" abstract="false" name="AdoptionOfASC326AndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_AccruedCommitmentsandContingenciesCurrent" abstract="false" name="AccruedCommitmentsandContingenciesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_TestingTypeAxis" abstract="true" name="TestingTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
<xs:element id="opk_CAMP4Member" abstract="true" name="CAMP4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ConvertibleNotesMember" abstract="true" name="ConvertibleNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_NonemployeeDirectorMember" abstract="true" name="NonemployeeDirectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ProceedsFromSubmissionOfInvestigationalNewDrug" abstract="false" name="ProceedsFromSubmissionOfInvestigationalNewDrug" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_ChiefTechnicalOfficerMember" abstract="true" name="ChiefTechnicalOfficerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_SalesReturnsMember" abstract="true" name="SalesReturnsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_OpkoDiagnosticsMember" abstract="true" name="OpkoDiagnosticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ModeXTherapeuticsIncMember" abstract="true" name="ModeXTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_LineOfCreditFacility50OrMoreOfRevolvingCommitmentMember" abstract="true" name="LineOfCreditFacility50OrMoreOfRevolvingCommitmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_NIMSMember" abstract="true" name="NIMSMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_WaterfordIrelandFacilityMember" abstract="true" name="WaterfordIrelandFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_OtherCountriesMember" abstract="true" name="OtherCountriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_InProcessResearchandDevelopment" abstract="false" name="InProcessResearchandDevelopment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_ZebraMember" abstract="true" name="ZebraMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_HealthInsurersMember" abstract="true" name="HealthInsurersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ProceedsFromDevelopmentAndLicenseAgreementDelayedPayment" abstract="false" name="ProceedsFromDevelopmentAndLicenseAgreementDelayedPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_FederalTradeCommissionFilingFeesMember" abstract="true" name="FederalTradeCommissionFilingFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_PharmaceuticalMember" abstract="true" name="PharmaceuticalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_DebtInstrumentConvertibleDebtMaximumSharesIssuable" abstract="false" name="DebtInstrumentConvertibleDebtMaximumSharesIssuable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract" abstract="true" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="opk_RayaldeeMember" abstract="true" name="RayaldeeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_NewCreditAgreementMember" abstract="true" name="NewCreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" abstract="false" name="ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
<xs:element id="opk_CocrystalPharmaInc.Member" abstract="true" name="CocrystalPharmaInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_InventoryReceivedNotInvoicedCurrent" abstract="false" name="InventoryReceivedNotInvoicedCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="opk_FineTechMember" abstract="true" name="FineTechMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_BusinessAcquisitionEscrowPeriod" abstract="false" name="BusinessAcquisitionEscrowPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="opk_SummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="opk_BusinessAcquisitionPercentOfSharesDepositedInEscrow" abstract="false" name="BusinessAcquisitionPercentOfSharesDepositedInEscrow" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="opk_IncreaseDecreaseInEquitySecuritiesFVNIAndDerivativeInstruments" abstract="false" name="IncreaseDecreaseInEquitySecuritiesFVNIAndDerivativeInstruments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_DrFrostMember" abstract="true" name="DrFrostMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_LesseeOperatingLeaseLeaseNotYetCommencedAreaOfOfficeSpace" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedAreaOfOfficeSpace" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
<xs:element id="opk_DebtInstrumentsNumberofFinancialInstitutions" abstract="false" name="DebtInstrumentsNumberofFinancialInstitutions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
<xs:element id="opk_GoodwillAcquiredDisposedOfDuringPeriod" abstract="false" name="GoodwillAcquiredDisposedOfDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_LitigationSettlementCorporateIntegrityAgreementTerm" abstract="false" name="LitigationSettlementCorporateIntegrityAgreementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="opk_EquitySecurityFVNIOwnershipPercent" abstract="false" name="EquitySecurityFVNIOwnershipPercent" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="opk_AccruedClinicalTrialsCurrent" abstract="false" name="AccruedClinicalTrialsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="opk_DebtInstrumentConvertibleConversionNoticeThresholdMinimum" abstract="false" name="DebtInstrumentConvertibleConversionNoticeThresholdMinimum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="opk_JPMorganChaseMember" abstract="true" name="JPMorganChaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_TransferOfIntellectualPropertyAndOtherMember" abstract="true" name="TransferOfIntellectualPropertyAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="opk_EstadoBankMember" abstract="true" name="EstadoBankMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>

3 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/01/24  Opko Health, Inc.                 10-K       12/31/23  122:18M                                    RDG Filings/FA
 5/15/23  Opko Health, Inc.                 S-8         5/15/23    4:98K                                    RDG Filings/FA
 5/03/23  Opko Health, Inc.                 10-Q        3/31/23   86:11M

24 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 7/15/22  Opko Health, Inc.                 8-K:1,5,9   7/14/22   12:504K
 5/13/22  Opko Health, Inc.                 8-K:1,3,5,9 5/09/22   14:1.3M
 5/04/22  Opko Health, Inc.                 8-K:1,8,9   4/29/22    2:145K
 1/18/22  Opko Health, Inc.                 8-K:1,9     1/14/22   12:1.6M
 9/03/21  Opko Health, Inc.                 8-K:1,9     8/30/21    2:1.3M
 7/29/21  Opko Health, Inc.                 10-Q        6/30/21   89:13M
 5/07/21  Opko Health, Inc.                 8-K:1,3,8,9 5/06/21   13:263K
 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
 7/31/20  Opko Health, Inc.                 10-Q        6/30/20   83:13M
10/29/19  Opko Health, Inc.                 8-K®:1,9   10/24/19   12:415K                                   Donnelley … Solutions/FA
 6/21/19  Opko Health, Inc.                 8-K:5,7,9   6/20/19    2:88K
 2/07/19  Opko Health, Inc.                 8-K:1,2,3,9 2/04/19    7:1.1M                                   Donnelley … Solutions/FA
 3/01/18  Opko Health, Inc.                 10-K       12/31/17  111:16M
 8/08/16  Opko Health, Inc.                 10-Q        6/30/16   80:10M
 3/25/16  Opko Health, Inc.                 DEF 14A     5/05/16    1:498K                                   Donnelley … Solutions/FA
11/12/13  Opko Health, Inc.                 10-Q        9/30/13   76:14M
 2/05/13  Opko Health, Inc.                 8-K:1,2,3,8 1/30/13    3:751K                                   Donnelley … Solutions/FA
11/09/11  Opko Health, Inc.                 10-Q        9/30/11   34:2.7M                                   Donnelley … Solutions/FA
 7/28/11  Opko Health, Inc.                 10-K/A     12/31/10    4:393K                                   Donnelley … Solutions/FA
 7/05/11  Opko Health, Inc.                 10-Q/A      3/31/11    4:164K                                   Donnelley … Solutions/FA
11/09/09  Opko Health, Inc.                 10-Q        9/30/09    7:373K                                   Donnelley … Solutions/FA
 9/24/09  Opko Health, Inc.                 8-K:1,3,5,8 9/18/09    6:2.7M                                   Donnelley … Solutions/FA
 8/08/08  Opko Health, Inc.                 10-Q        6/30/08    8:1M                                     Toppan Merrill/FA
 4/02/07  Opko Health, Inc.                 8-K:1,2,3,5 3/27/07   20:2M                                     Bowne of Atlanta Inc./FA
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