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Shire plc – ‘10-K’ for 12/31/17 – ‘EX-101.LAB’

On:  Friday, 2/16/18, at 6:16pm ET   ·   As of:  2/20/18   ·   For:  12/31/17   ·   Accession #:  936402-18-7   ·   File #:  1-37896

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  As Of               Filer                 Filing    For·On·As Docs:Size

 2/20/18  Shire plc                         10-K       12/31/17  168:31M

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   2.74M 
 2: EX-10.22    Material Contract                                   HTML     58K 
 3: EX-10.23    Material Contract                                   HTML     54K 
 4: EX-10.24    Material Contract                                   HTML    120K 
 5: EX-21       Subsidiaries List                                   HTML     88K 
 6: EX-23.1     Consent of Experts or Counsel                       HTML     44K 
 7: EX-23.2     Consent of Experts or Counsel                       HTML     44K 
 8: EX-31.1     Certification -- §302 - SOA'02                      HTML     50K 
 9: EX-31.2     Certification -- §302 - SOA'02                      HTML     49K 
10: EX-32.1     Certification -- §906 - SOA'02                      HTML     45K 
17: R1          Document and Entity Information                     HTML     72K 
18: R2          Consolidated Balance Sheets                         HTML    132K 
19: R3          Consolidated Balance Sheets (Parenthetical)         HTML     54K 
20: R4          Consolidated Statements of Operations               HTML    143K 
21: R5          Consolidated Statements of Comprehensive Income     HTML     85K 
22: R6          Consolidated Statements of Comprehensive Income     HTML     52K 
                (Parenthetical)                                                  
23: R7          Consolidated Statement of Changes in Equity         HTML    111K 
24: R8          Consolidated Statement of Changes in Equity         HTML     52K 
                (Parenthetical)                                                  
25: R9          Consolidated Statements of Cash Flows               HTML    144K 
26: R10         Description of Operations                           HTML     47K 
27: R11         Summary of Significant Accounting Policies          HTML    168K 
28: R12         Business Combinations                               HTML    181K 
29: R13         Collaborative and Other Licensing Arrangements      HTML     62K 
30: R14         Integration and Acquisition Costs                   HTML     71K 
31: R15         Reorganization Costs                                HTML     49K 
32: R16         Results of Discontinued Operations                  HTML     51K 
33: R17         Accounts Receivable, Net                            HTML     61K 
34: R18         Inventories                                         HTML     53K 
35: R19         Prepaid Expenses and Other Current Assets           HTML     55K 
36: R20         Property, Plant and Equipment, Net                  HTML     61K 
37: R21         Intangible Assets                                   HTML     94K 
38: R22         Goodwill                                            HTML     53K 
39: R23         Fair Value Measurement                              HTML    179K 
40: R24         Financial Instruments                               HTML    141K 
41: R25         Accounts Payable and Accrued Expenses               HTML     56K 
42: R26         Borrowings and Capital Leases                       HTML    128K 
43: R27         Other Current Liabilities                           HTML     55K 
44: R28         Retirement and Other Benefit Programs               HTML    531K 
45: R29         Accumulated Other Comprehensive Income/(Loss)       HTML    130K 
46: R30         Taxation                                            HTML    226K 
47: R31         Earnings Per Share                                  HTML     90K 
48: R32         Share-based Compensation Plans                      HTML    181K 
49: R33         Commitments and Contingencies                       HTML     65K 
50: R34         Legal and Other Proceedings                         HTML     67K 
51: R35         Shareholders' Equity                                HTML     58K 
52: R36         Segment Reporting                                   HTML    158K 
53: R37         Agreements and Transactions                         HTML     55K 
54: R38         Subsequent Events                                   HTML     47K 
55: R39         Guarantor Financial Information                     HTML   1.06M 
56: R40         Quarterly Results of Operations (Unaudited)         HTML    124K 
57: R41         Schedule II - Valuation and Qualifying Accounts     HTML    106K 
58: R42         Notes to the New Shire Income Access Share Trust    HTML     57K 
                Financial Statements                                             
59: R43         Summary of Significant Accounting Policies          HTML    257K 
                (Policies)                                                       
60: R44         Summary of Significant Accounting Policies          HTML     61K 
                (Tables)                                                         
61: R45         Business Combinations (Tables)                      HTML    150K 
62: R46         Integration and Acquisition Costs (Tables)          HTML     64K 
63: R47         Accounts Receivable, Net (Tables)                   HTML     55K 
64: R48         Inventories (Tables)                                HTML     53K 
65: R49         Prepaid Expenses and Other Current Assets (Tables)  HTML     55K 
66: R50         Property, Plant and Equipment, Net (Tables)         HTML     61K 
67: R51         Intangible Assets (Tables)                          HTML     94K 
68: R52         Goodwill (Tables)                                   HTML     52K 
69: R53         Fair Value Measurement (Tables)                     HTML    174K 
70: R54         Financial Instruments (Tables)                      HTML    134K 
71: R55         Accounts Payable and Accrued Expenses (Tables)      HTML     56K 
72: R56         Borrowings and Capital Leases (Tables)              HTML    118K 
73: R57         Other Current Liabilities (Tables)                  HTML     54K 
74: R58         Retirement and Other Benefit Programs (Tables)      HTML    519K 
75: R59         Accumulated Other Comprehensive Income/(Loss)       HTML    129K 
                (Tables)                                                         
76: R60         Taxation Taxation (Tables)                          HTML    221K 
77: R61         Earnings Per Share (Tables)                         HTML     91K 
78: R62         Share-based Compensation Plans (Tables)             HTML    158K 
79: R63         Commitments and Contingencies (Tables)              HTML     51K 
80: R64         Segment Reporting (Tables)                          HTML    164K 
81: R65         Guarantor Financial Information (Tables)            HTML    947K 
82: R66         Quarterly Results of Operations (Unaudited)         HTML    124K 
                (Tables)                                                         
83: R67         Summary of Significant Accounting Policies          HTML     79K 
                (Narrative) (Details)                                            
84: R68         Summary of Significant Accounting Policies (Useful  HTML     55K 
                Lives of Property, Plant and Equipment) (Details)                
85: R69         Business Combinations (Acquisition of Baxalta)      HTML    117K 
                (Narrative) (Details)                                            
86: R70         Business Combinations (Baxalta Purchase Price       HTML     57K 
                Consideration) (Details)                                         
87: R71         Business Combinations (Baxalta Assets Acquired and  HTML    136K 
                Liabilities Assumed) (Details)                                   
88: R72         Business Combinations (Baxalta Pro Forma            HTML     62K 
                Information) (Details)                                           
89: R73         Business Combinations (Acquisition of Dyax)         HTML    107K 
                (Narrative) (Details)                                            
90: R74         Business Combinations (Dyax Assets Acquired and     HTML    102K 
                Liabilities Assumed) (Details)                                   
91: R75         Business Combinations (Dyax Pro Forma Information)  HTML     58K 
                (Details)                                                        
92: R76         Collaborative and Other Licensing Arrangements      HTML     65K 
                (Narrative) (Details)                                            
93: R77         Integration and Acquisition Costs (Narrative)       HTML     76K 
                (Details)                                                        
94: R78         Integration and Acquisition Costs (Summary of       HTML     56K 
                Employee Termination Related Reserve and Other)                  
                (Details)                                                        
95: R79         Reorganization Costs (Narrative) (Details)          HTML     51K 
96: R80         Results of Discontinued Operations (Narrative)      HTML     70K 
                (Details)                                                        
97: R81         Accounts Receivable, Net (Narrative) (Details)      HTML     50K 
98: R82         Accounts Receivable, Net (Summary of Reserve for    HTML     53K 
                Discounts and Allowances) (Details)                              
99: R83         Inventories (Summary of Inventories) (Details)      HTML     54K 
100: R84         Prepaid Expenses and Other Current Assets           HTML     56K  
                (Details)                                                        
101: R85         Property, Plant and Equipment, Net (Summary of      HTML     61K  
                Property, Plant and Equipment) (Details)                         
102: R86         Property, Plant and Equipment, Net (Narrative)      HTML     62K  
                (Details)                                                        
103: R87         Intangible Assets (Summary of Intangible Assets)    HTML     59K  
                (Details)                                                        
104: R88         Intangible Assets (Roll Forward) (Details)          HTML     56K  
105: R89         Intangible Assets (Narrative) (Details)             HTML     60K  
106: R90         Intangible Assets (Future Amortization Expense)     HTML     54K  
                (Details)                                                        
107: R91         Goodwill (Rollforward of Goodwill) (Details)        HTML     51K  
108: R92         Fair Value Measurement (Assets and Liabilities      HTML     83K  
                Measured on a Recurring Basis) (Details)                         
109: R93         Fair Value Measurement (Assets and Liabilities      HTML     54K  
                Measure at Fair Value on Recurring Basis using                   
                Level 3 Inputs) (Details)                                        
110: R94         Fair Value Measurement (Qualitative Information     HTML     76K  
                About Liabilities Measured at Fair Value on                      
                Recurring Basis Using Level 3 Inputs) (Details)                  
111: R95         Fair Value Measurement (Financial Assets and        HTML     61K  
                Liabilities Not Measured on a Recurring Basis)                   
                (Details)                                                        
112: R96         Fair Value Measurement (Narrative) (Details)        HTML     58K  
113: R97         Financial Instruments (Summary of Derivative        HTML     59K  
                Instruments) (Details)                                           
114: R98         Financial Instruments (Narrative) (Details)         HTML     58K  
115: R99         Financial Instruments (Derivative Income Statement  HTML     65K  
                Location, Gains & Losses) (Details)                              
116: R100        Financial Instruments (Foreign Exchange Risk and    HTML     84K  
                Its Classification on Balance Sheet) (Details)                   
117: R101        Accounts Payable and Accrued Expenses (Details)     HTML     55K  
118: R102        Borrowings and Capital Leases (Short-term           HTML     61K  
                Borrowings) (Details)                                            
119: R103        Borrowings and Capital Leases (Long-term            HTML     66K  
                Borrowings) (Details)                                            
120: R104        Borrowings and Capital Leases (Maturities)          HTML     68K  
                (Details)                                                        
121: R105        Borrowings and Capital Leases (Senior Notes Issued  HTML     68K  
                by SAIIDAC) (Details)                                            
122: R106        Borrowings and Capital Leases (Senior Notes         HTML     77K  
                Related to Baxalta Acquisition) (Details)                        
123: R107        Borrowings and Capital Leases (Narrative)           HTML     88K  
                (Details)                                                        
124: R108        Other Current Liabilities (Details)                 HTML     54K  
125: R109        Retirement and Other Benefit Programs (Change in    HTML    138K  
                Benefit Obligations and Fair Value of Plan Assets)               
                (Details)                                                        
126: R110        Retirement and Other Benefit Programs (Narrative)   HTML     83K  
                (Details)                                                        
127: R111        Retirement and Other Benefit Programs (Summary of   HTML     53K  
                Funded Status of Plan) (Details)                                 
128: R112        Retirement and Other Benefit Programs (Expected     HTML     66K  
                Net Pension and OPEB Plan Payments for the Next 10               
                Years) (Details)                                                 
129: R113        Retirement and Other Benefit Programs (Summary of   HTML     62K  
                Amounts Recorded in AOCI) (Details)                              
130: R114        Retirement and Other Benefit Programs (Summary of   HTML     65K  
                Net Periodic Benefit Cost) (Details)                             
131: R115        Retirement and Other Benefit Programs               HTML     75K  
                (Weighted-Average Assumptions Used for Benefit                   
                Obligation and Net Periodic Benefit Cost)                        
                (Details)                                                        
132: R116        Retirement and Other Benefit Programs (Fair Value   HTML    146K  
                Measurements of Plan Assets) (Details)                           
133: R117        Retirement and Other Benefit Programs (Funded and   HTML     66K  
                Unfunded Statuses of Plans) (Details)                            
134: R118        Accumulated Other Comprehensive Income/(Loss)       HTML     76K  
                (Summary of Changes in Accumulated Other                         
                Comprehensive Income/(Loss)) (Details)                           
135: R119        Accumulated Other Comprehensive Income/(Loss)       HTML     90K  
                (Reclassifications from Accumulated Other                        
                Comprehensive Income) (Details)                                  
136: R120        Taxation (Narrative) (Details)                      HTML     86K  
137: R121        Taxation (Components of Pre-tax Income) (Details)   HTML     56K  
138: R122        Taxation (Pretax Income from Continuing Operations  HTML     79K  
                and Provision for Income Taxes) (Details)                        
139: R123        Taxation (Effective Income Tax Rate                 HTML    124K  
                Reconciliation, and Statutory Tax Rates) (Details)               
140: R124        Taxation (Rollforward of Unrecognized Tax           HTML     71K  
                Benefits) (Details)                                              
141: R125        Taxation (Deferred Tax Assets and Liabilities, and  HTML    101K  
                Valuation Allowances) (Details)                                  
142: R126        Taxation (Operating Loss and Tax Credit             HTML     72K  
                Carryforwards, and Their Expiration Dates)                       
                (Details)                                                        
143: R127        Earnings Per Share (Calculation of EPS) (Details)   HTML    100K  
144: R128        Earnings Per Share (Summary of Antidilutive         HTML     48K  
                Securities) (Details)                                            
145: R129        Share-based Compensation Plans (Share-based         HTML     63K  
                Compensation Expense) (Details)                                  
146: R130        Share-based Compensation Plans (Narrative)          HTML    174K  
                (Details)                                                        
147: R131        Share-based Compensation Plans (Summary of Awards   HTML     85K  
                Outstanding and Vesting Schedules) (Details)                     
148: R132        Share-based Compensation Plans (Stock Options and   HTML    107K  
                SARs) (Details)                                                  
149: R133        Share-based Compensation Plans (Performance Share   HTML     74K  
                Awards) (Details)                                                
150: R134        Share-based Compensation Plans (Fair Value          HTML     62K  
                Assumptions) (Details)                                           
151: R135        Commitments and Contingencies (Future Minimum       HTML     62K  
                Lease Payments) (Details)                                        
152: R136        Commitments and Contingencies (Narrative)           HTML     63K  
                (Details)                                                        
153: R137        Legal and Other Proceedings (Narrative) (Details)   HTML     45K  
154: R138        Shareholders' Equity (Narrative) (Details)          HTML     69K  
155: R139        Segment Reporting (Narrative) (Details)             HTML     46K  
156: R140        Segment Reporting (Revenues and Long-lived Assets   HTML     64K  
                by Geographic Location) (Details)                                
157: R141        Segment Reporting (Revenues and Accounts            HTML     65K  
                Receivable by Major Customers) (Details)                         
158: R142        Segment Reporting (Revenue by Product) (Details)    HTML    132K  
159: R143        Agreements and Transactions with Baxter             HTML     68K  
                (Narrative) (Detail)                                             
160: R144        Guarantor Financial Information (Senior Notes)      HTML     67K  
                (Details)                                                        
161: R145        Guarantor Financial Information (Consolidating      HTML    206K  
                Balance Sheets) (Details)                                        
162: R146        Guarantor Financial Information (Consolidating      HTML    218K  
                Statements of Income) (Details)                                  
163: R147        Guarantor Financial Information (Condensed          HTML    160K  
                Consolidating Statement of Cash Flows) (Details)                 
164: R148        Schedule II - Valuation and Qualifying Accounts     HTML     67K  
                (Details)                                                        
165: R149        Quarterly Results of Operations (Unaudited)         HTML     93K  
                (Details)                                                        
167: XML         IDEA XML File -- Filing Summary                      XML    308K  
166: EXCEL       IDEA Workbook of Financial Reports                  XLSX    236K  
11: EX-101.INS  XBRL Instance -- shpgf-20171231                      XML  10.49M 
13: EX-101.CAL  XBRL Calculations -- shpgf-20171231_cal              XML    470K 
14: EX-101.DEF  XBRL Definitions -- shpgf-20171231_def               XML   2.08M 
15: EX-101.LAB  XBRL Labels -- shpgf-20171231_lab                    XML   3.49M 
16: EX-101.PRE  XBRL Presentations -- shpgf-20171231_pre             XML   2.56M 
12: EX-101.SCH  XBRL Schema -- shpgf-20171231                        XSD    363K 
168: ZIP         XBRL Zipped Folder -- 0000936402-18-000007-xbrl      Zip    685K

‘EX-101.LAB’   —   XBRL Labels — shpgf-20171231_lab

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:label id="lab_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859" xlink:to="lab_us-gaap_BusinessAcquisitionAxis_4C75BF54B1ED85E5B707768D0261C859" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Acquiree [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2" xlink:to="lab_us-gaap_BusinessAcquisitionAcquireeDomain_C96F22FD3ADFAF38323D768D0262CBA2" xlink:type="arc"/>
<link:label id="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77_verboseLabel_en-US" xlink:label="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta notes </link:label>
<link:label id="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77_label_en-US" xlink:label="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Baxalta Incorporated [Member] </link:label>
<link:label id="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77_documentation_en-US" xlink:label="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BaxaltaIncorporatedMember" xlink:label="loc_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:to="lab_shpgf_BaxaltaIncorporatedMember_8CE9C16960406AFE127F768D0262CC77" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7" xlink:to="lab_us-gaap_LongtermDebtTypeAxis_A8CC0CE4A8B8900F467A768D0262C8B7" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:label id="lab_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5" xlink:to="lab_us-gaap_LongtermDebtTypeDomain_9508CD1B381F522B985D768D0262DBD5" xlink:type="arc"/>
<link:label id="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA_terseLabel_en-US" xlink:label="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> November 2015 Facilities Agreement </link:label>
<link:label id="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA_label_en-US" xlink:label="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> November 2015 Facilities Agreement [Member] </link:label>
<link:label id="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA_documentation_en-US" xlink:label="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_November2015FacilitiesAgreementMember" xlink:label="loc_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:to="lab_shpgf_November2015FacilitiesAgreementMember_EC7FC75B8E80A5560C2B768D026374AA" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369" xlink:to="lab_us-gaap_DebtInstrumentLineItems_0EBC1E1DE96432141599768D02636369" xlink:type="arc"/>
<link:label id="lab_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770_terseLabel_en-US" xlink:label="lab_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior notes </link:label>
<link:label id="lab_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770_label_en-US" xlink:label="lab_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Senior Notes, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeniorLongTermNotes" xlink:label="loc_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770" xlink:to="lab_us-gaap_SeniorLongTermNotes_A619FE03629A2F7221D3768D02638770" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Borrowings under the Facilities Agreement </link:label>
<link:label id="lab_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3_label_en-US" xlink:label="lab_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermLineOfCredit" xlink:label="loc_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3" xlink:to="lab_us-gaap_LongTermLineOfCredit_7401B6E214F34D61C5C4768D026387F3" xlink:type="arc"/>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_59A495ABB87EAA51384E768D026431CD_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_59A495ABB87EAA51384E768D026431CD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital leases </link:label>
<link:label id="lab_us-gaap_CapitalLeaseObligationsNoncurrent_59A495ABB87EAA51384E768D026431CD_label_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligationsNoncurrent_59A495ABB87EAA51384E768D026431CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Lease Obligations, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalLeaseObligationsNoncurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsNoncurrent_59A495ABB87EAA51384E768D026431CD" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SecuredLongTermDebt_F54693E3EFB082F94A17768D02651DB7_terseLabel_en-US" xlink:label="lab_us-gaap_SecuredLongTermDebt_F54693E3EFB082F94A17768D02651DB7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other borrowings </link:label>
<link:label id="lab_us-gaap_SecuredLongTermDebt_F54693E3EFB082F94A17768D02651DB7_label_en-US" xlink:label="lab_us-gaap_SecuredLongTermDebt_F54693E3EFB082F94A17768D02651DB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Secured Long-term Debt, Noncurrent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuredLongTermDebt" xlink:label="loc_us-gaap_SecuredLongTermDebt_F54693E3EFB082F94A17768D02651DB7" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total long-term obligations </link:label>
<link:label id="lab_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5_label_en-US" xlink:label="lab_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5" xlink:to="lab_us-gaap_LongTermDebt_440AC56F249E191B538476A000C2C6E5" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtAndCapitalLeaseObligations_D5680E3FC3B9EAA2342D768D026609A3_terseLabel_en-US" xlink:label="lab_us-gaap_DebtAndCapitalLeaseObligations_D5680E3FC3B9EAA2342D768D026609A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Total borrowings and capital leases </link:label>
<link:label id="lab_us-gaap_DebtAndCapitalLeaseObligations_D5680E3FC3B9EAA2342D768D026609A3_label_en-US" xlink:label="lab_us-gaap_DebtAndCapitalLeaseObligations_D5680E3FC3B9EAA2342D768D026609A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt and Capital Lease Obligations </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtAndCapitalLeaseObligations" xlink:label="loc_us-gaap_DebtAndCapitalLeaseObligations_D5680E3FC3B9EAA2342D768D026609A3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EarningsPerShareAbstract_4416AB52D904786C6B757235621F0890_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareAbstract_4416AB52D904786C6B757235621F0890" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_4416AB52D904786C6B757235621F0890" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_829FA86AEC119C52ECAE723562223D1A_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_829FA86AEC119C52ECAE723562223D1A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income from continuing operations, net of taxes </link:label>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_829FA86AEC119C52ECAE723562223D1A_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_829FA86AEC119C52ECAE723562223D1A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_829FA86AEC119C52ECAE723562223D1A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_864CF9A6B13FCAB91F8072356224EA46_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_864CF9A6B13FCAB91F8072356224EA46" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Gain/(loss) from discontinued operations, net of taxes </link:label>
<link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_864CF9A6B13FCAB91F8072356224EA46_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_864CF9A6B13FCAB91F8072356224EA46" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest </link:label>
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<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7CE7557EA340BBAEB12372356224A83C_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7CE7557EA340BBAEB12372356224A83C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Basic (in shares) </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7CE7557EA340BBAEB12372356224A83C_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7CE7557EA340BBAEB12372356224A83C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Basic </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7CE7557EA340BBAEB12372356224A83C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_258DC013ED9562F529DF7235622447AC_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_258DC013ED9562F529DF7235622447AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Effect of dilutive shares: </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_258DC013ED9562F529DF7235622447AC_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_258DC013ED9562F529DF7235622447AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Incremental Weighted Average Shares Attributable to Dilutive Effect [Abstract] </link:label>
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<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_3E58EE6C748859FBAEC77235622405E3_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_3E58EE6C748859FBAEC77235622405E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share-based awards to employees (in shares) </link:label>
<link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_3E58EE6C748859FBAEC77235622405E3_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_3E58EE6C748859FBAEC77235622405E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_3E58EE6C748859FBAEC77235622405E3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_08C29D75B3A520FBBEDE723562242A4E_totalLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_08C29D75B3A520FBBEDE723562242A4E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Diluted (in shares) </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_08C29D75B3A520FBBEDE723562242A4E_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_08C29D75B3A520FBBEDE723562242A4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Diluted </link:label>
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<link:label id="lab_us-gaap_EarningsPerShareBasicAbstract_0BD7B9E6B628A453761A72359C983E9F_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAbstract_0BD7B9E6B628A453761A72359C983E9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings per Ordinary Share – basic </link:label>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_302A0B2FF3875F26AE4E7235CDAC0903_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_302A0B2FF3875F26AE4E7235CDAC0903" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings from continuing operations (in usd per share) </link:label>
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<link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_AE3140F7459B27FD77237235CDB60B4D_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_AE3140F7459B27FD77237235CDB60B4D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings/(loss) from discontinued operations (in usd per share) </link:label>
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<link:label id="lab_us-gaap_EarningsPerShareBasic_30978543408CC01BE14272378FCC4C9F_totalLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic_30978543408CC01BE14272378FCC4C9F" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Earnings per Ordinary Share - basic (in usd per share) </link:label>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_B7F5148CDC0424E43C477236484A76C9_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_B7F5148CDC0424E43C477236484A76C9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings from continuing operations (in usd per share) </link:label>
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<link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_D55248C05DA3032C4F0072364854FFB3_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_D55248C05DA3032C4F0072364854FFB3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings/(loss) from discontinued operations (in usd per share) </link:label>
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<link:label id="lab_us-gaap_EarningsPerShareDiluted_4543DAD4839F730FDBF8723801599E20_totalLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted_4543DAD4839F730FDBF8723801599E20" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Earnings per Ordinary Share - diluted (in usd per share) </link:label>
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<link:label id="lab_us-gaap_IncomeStatementAbstract_78EDD19BC16C0F4B16938B712CCC08F5_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract_78EDD19BC16C0F4B16938B712CCC08F5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement [Abstract] </link:label>
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<link:label id="lab_us-gaap_StatementTable_DBB48C096CBC3A00B1968B712CCCA125_label_en-US" xlink:label="lab_us-gaap_StatementTable_DBB48C096CBC3A00B1968B712CCCA125" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Table] </link:label>
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<link:label id="lab_dei_LegalEntityAxis_8515F8FA4B9DC644211C8B712CCC0C09_label_en-US" xlink:label="lab_dei_LegalEntityAxis_8515F8FA4B9DC644211C8B712CCC0C09" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Legal Entity [Axis] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_8515F8FA4B9DC644211C8B712CCC0C09" xlink:type="locator"/>
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<link:label id="lab_dei_EntityDomain_9104D3D03AE70C5CA4098B712CCC817F_label_en-US" xlink:label="lab_dei_EntityDomain_9104D3D03AE70C5CA4098B712CCC817F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Entity [Domain] </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_9104D3D03AE70C5CA4098B712CCC817F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityDomain_9104D3D03AE70C5CA4098B712CCC817F" xlink:to="lab_dei_EntityDomain_9104D3D03AE70C5CA4098B712CCC817F" xlink:type="arc"/>
<link:label id="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3_terseLabel_en-US" xlink:label="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Shire Income Access Share Trust </link:label>
<link:label id="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3_label_en-US" xlink:label="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shire Income Access Share Trust [Member] </link:label>
<link:label id="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3_documentation_en-US" xlink:label="lab_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shire Income Access Share Trust [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ShireIncomeAccessShareTrustMember" xlink:label="loc_shpgf_ShireIncomeAccessShareTrustMember_1094FACB5CE280D252AF8B712CCC3BA3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StatementLineItems_59E52D5C0BF3FFF647918B712CCCE23A_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems_59E52D5C0BF3FFF647918B712CCCE23A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:label id="lab_us-gaap_StatementLineItems_59E52D5C0BF3FFF647918B712CCCE23A_label_en-US" xlink:label="lab_us-gaap_StatementLineItems_59E52D5C0BF3FFF647918B712CCCE23A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_59E52D5C0BF3FFF647918B712CCCE23A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RevenuesAbstract_204CB4F627E510CFFBBB8B712CCC72E4_terseLabel_en-US" xlink:label="lab_us-gaap_RevenuesAbstract_204CB4F627E510CFFBBB8B712CCC72E4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues: </link:label>
<link:label id="lab_us-gaap_RevenuesAbstract_204CB4F627E510CFFBBB8B712CCC72E4_label_en-US" xlink:label="lab_us-gaap_RevenuesAbstract_204CB4F627E510CFFBBB8B712CCC72E4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenues [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_204CB4F627E510CFFBBB8B712CCC72E4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SalesRevenueGoodsNet_78BAE07F193944DD28368B712CCCF012_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_78BAE07F193944DD28368B712CCCF012" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product sales </link:label>
<link:label id="lab_us-gaap_SalesRevenueGoodsNet_78BAE07F193944DD28368B712CCCF012_label_en-US" xlink:label="lab_us-gaap_SalesRevenueGoodsNet_78BAE07F193944DD28368B712CCCF012" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Revenue, Goods, Net </link:label>
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<link:label id="lab_us-gaap_RoyaltyRevenue_B8F53689F460D40FA8128B712CCC91CA_terseLabel_en-US" xlink:label="lab_us-gaap_RoyaltyRevenue_B8F53689F460D40FA8128B712CCC91CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Royalties and other revenues </link:label>
<link:label id="lab_us-gaap_RoyaltyRevenue_B8F53689F460D40FA8128B712CCC91CA_label_en-US" xlink:label="lab_us-gaap_RoyaltyRevenue_B8F53689F460D40FA8128B712CCC91CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Royalty Revenue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RoyaltyRevenue" xlink:label="loc_us-gaap_RoyaltyRevenue_B8F53689F460D40FA8128B712CCC91CA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Revenues_C5373E9473F8F28257628B712CCC937C_totalLabel_en-US" xlink:label="lab_us-gaap_Revenues_C5373E9473F8F28257628B712CCC937C" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:label id="lab_us-gaap_Revenues_C5373E9473F8F28257628B712CCC937C_label_en-US" xlink:label="lab_us-gaap_Revenues_C5373E9473F8F28257628B712CCC937C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_C5373E9473F8F28257628B712CCC937C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CostsAndExpensesAbstract_A4C4F9583389F37939D98B712CCCB569_label_en-US" xlink:label="lab_us-gaap_CostsAndExpensesAbstract_A4C4F9583389F37939D98B712CCCB569" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Costs and Expenses [Abstract] </link:label>
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<link:label id="lab_us-gaap_CostOfGoodsSold_6E05DC8B93887515CE0C8B712CCCB2AD_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_6E05DC8B93887515CE0C8B712CCCB2AD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of sales </link:label>
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<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_6DE57EF263833D3370178B712CCC78D2_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_6DE57EF263833D3370178B712CCC78D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Research and development </link:label>
<link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_6DE57EF263833D3370178B712CCC78D2_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense_6DE57EF263833D3370178B712CCC78D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research and Development Expense </link:label>
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<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1A40871D45A51AA9F2C58B712CCC1D96_terseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpense_1A40871D45A51AA9F2C58B712CCC1D96" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Selling, general and administrative </link:label>
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<link:label id="lab_shpgf_AmortizationOfIntangibleAssetsAcquiredBusinessCombination_7840213A42576134E5BE8B712CCC4332_terseLabel_en-US" xlink:label="lab_shpgf_AmortizationOfIntangibleAssetsAcquiredBusinessCombination_7840213A42576134E5BE8B712CCC4332" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of acquired intangible assets </link:label>
<link:label id="lab_shpgf_AmortizationOfIntangibleAssetsAcquiredBusinessCombination_7840213A42576134E5BE8B712CCC4332_label_en-US" xlink:label="lab_shpgf_AmortizationOfIntangibleAssetsAcquiredBusinessCombination_7840213A42576134E5BE8B712CCC4332" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Intangible Assets Acquired, Business Combination </link:label>
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<link:label id="lab_us-gaap_RestructuringCharges_6C844E0DE4C6ADD97C818B712CCCDF15_terseLabel_en-US" xlink:label="lab_us-gaap_RestructuringCharges_6C844E0DE4C6ADD97C818B712CCCDF15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reorganization costs </link:label>
<link:label id="lab_us-gaap_RestructuringCharges_6C844E0DE4C6ADD97C818B712CCCDF15_label_en-US" xlink:label="lab_us-gaap_RestructuringCharges_6C844E0DE4C6ADD97C818B712CCCDF15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring Charges </link:label>
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<link:label id="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763_negatedLabel_en-US" xlink:label="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Gain on sale of product rights </link:label>
<link:label id="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763_label_en-US" xlink:label="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Gain (Loss) on Disposition of Product Rights </link:label>
<link:label id="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763_documentation_en-US" xlink:label="lab_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> The gain (loss) following re-measurement of the contingent consideration receivable from the divestment of the entity's products. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_GainLossOnDispositionOfProductRights" xlink:label="loc_shpgf_GainLossOnDispositionOfProductRights_BF079AA192825607E1248B712CCCA763" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total operating expenses </link:label>
<link:label id="lab_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03_label_en-US" xlink:label="lab_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Expenses </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03" xlink:to="lab_us-gaap_OperatingExpenses_BFDD4EBF894D30DB263F8B712CCC3F03" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingIncomeLoss_240BEEA4831FC0DBE57F8B712CCC1F47_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_240BEEA4831FC0DBE57F8B712CCC1F47" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Operating income from continuing operations </link:label>
<link:label id="lab_us-gaap_OperatingIncomeLoss_240BEEA4831FC0DBE57F8B712CCC1F47_label_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss_240BEEA4831FC0DBE57F8B712CCC1F47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Income (Loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_240BEEA4831FC0DBE57F8B712CCC1F47" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_DC27F3746AA2BF40366F8B712CCC33FA_terseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_DC27F3746AA2BF40366F8B712CCC33FA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Interest income </link:label>
<link:label id="lab_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_DC27F3746AA2BF40366F8B712CCC33FA_label_en-US" xlink:label="lab_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_DC27F3746AA2BF40366F8B712CCC33FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Income, Deposits with Financial Institutions </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestIncomeDepositsWithFinancialInstitutions" xlink:label="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_DC27F3746AA2BF40366F8B712CCC33FA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InterestExpense_B3EBBAEC90B7D4A6873B8B712CCCF1A9_negatedLabel_en-US" xlink:label="lab_us-gaap_InterestExpense_B3EBBAEC90B7D4A6873B8B712CCCF1A9" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Interest expense </link:label>
<link:label id="lab_us-gaap_InterestExpense_B3EBBAEC90B7D4A6873B8B712CCCF1A9_label_en-US" xlink:label="lab_us-gaap_InterestExpense_B3EBBAEC90B7D4A6873B8B712CCCF1A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_B3EBBAEC90B7D4A6873B8B712CCCF1A9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_62A28B774120529B62E98B712CCC4AB9_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_62A28B774120529B62E98B712CCC4AB9" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other income/(expense), net </link:label>
<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_62A28B774120529B62E98B712CCC4AB9_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_62A28B774120529B62E98B712CCC4AB9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_62A28B774120529B62E98B712CCC4AB9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NonoperatingIncomeExpense_CD4E0887400547703DA88B712CCC7FC3_totalLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_CD4E0887400547703DA88B712CCC7FC3" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total other expense, net </link:label>
<link:label id="lab_us-gaap_NonoperatingIncomeExpense_CD4E0887400547703DA88B712CCC7FC3_label_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense_CD4E0887400547703DA88B712CCC7FC3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Nonoperating Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_CD4E0887400547703DA88B712CCC7FC3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_23074127537D974D0FE48B712CCC6ACE_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_23074127537D974D0FE48B712CCC6ACE" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Income from continuing operations before income taxes and equity in earnings/(losses) of equity method investees </link:label>
<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_23074127537D974D0FE48B712CCC6ACE_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_23074127537D974D0FE48B712CCC6ACE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_23074127537D974D0FE48B712CCC6ACE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_1286C10BE80B9E46A0268B712CCC58F8_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_1286C10BE80B9E46A0268B712CCC58F8" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Income taxes </link:label>
<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_1286C10BE80B9E46A0268B712CCC58F8_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_1286C10BE80B9E46A0268B712CCC58F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Expense (Benefit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_1286C10BE80B9E46A0268B712CCC58F8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_399E66867A04F1C43C5F8B712CCCB719_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_399E66867A04F1C43C5F8B712CCCB719" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity in earnings/(losses) of equity method investees, net of taxes </link:label>
<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_399E66867A04F1C43C5F8B712CCCB719_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_399E66867A04F1C43C5F8B712CCCB719" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income (Loss) from Equity Method Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_399E66867A04F1C43C5F8B712CCCB719" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_F588F305331377E8B1648B712CCC620A_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_F588F305331377E8B1648B712CCC620A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Income from continuing operations, net of taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_F588F305331377E8B1648B712CCC620A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_0C55407CA2BAF57597798B712CCC9931_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_0C55407CA2BAF57597798B712CCC9931" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Gain/(loss) from discontinued operations, net of taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_0C55407CA2BAF57597798B712CCC9931" xlink:type="locator"/>
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<link:label id="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0_terseLabel_en-US" xlink:label="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dividend income </link:label>
<link:label id="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0_label_en-US" xlink:label="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Dividends Received From Parent </link:label>
<link:label id="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0_documentation_en-US" xlink:label="lab_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Dividends Received From Parent </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_DividendsReceivedFromParent" xlink:label="loc_shpgf_DividendsReceivedFromParent_5D0E988E33FDA0D5C1088B712CCCCAB0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_BE4DBC669CD17F7445988B712CCC2028_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_BE4DBC669CD17F7445988B712CCC2028" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average number of shares: </link:label>
<link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_BE4DBC669CD17F7445988B712CCC2028_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_BE4DBC669CD17F7445988B712CCC2028" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Weighted Average Number of Shares Outstanding, Diluted [Abstract] </link:label>
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<link:label id="lab_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_F4B33AD98D5A8AF27FC0677F4101B791_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_F4B33AD98D5A8AF27FC0677F4101B791" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Defined Benefit Plans Disclosures [Table] </link:label>
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<link:label id="lab_us-gaap_PensionPlansDefinedBenefitMember_55421907750602588259677F4101D568_terseLabel_en-US" xlink:label="lab_us-gaap_PensionPlansDefinedBenefitMember_55421907750602588259677F4101D568" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pensions </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_55421907750602588259677F4101D568" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_3A81B0315AEF351EA6E4677F4102007C_terseLabel_en-US" xlink:label="lab_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_3A81B0315AEF351EA6E4677F4102007C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> OPEB </link:label>
<link:label id="lab_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_3A81B0315AEF351EA6E4677F4102007C_label_en-US" xlink:label="lab_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_3A81B0315AEF351EA6E4677F4102007C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Postretirement Benefits Plan [Member] </link:label>
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<link:label id="lab_us-gaap_RetirementPlanSponsorLocationAxis_144423A5BCABE67E58D2677F4102F488_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanSponsorLocationAxis_144423A5BCABE67E58D2677F4102F488" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Sponsor Location [Axis] </link:label>
<link:label id="lab_us-gaap_RetirementPlanSponsorLocationAxis_144423A5BCABE67E58D2677F4102F488_label_en-US" xlink:label="lab_us-gaap_RetirementPlanSponsorLocationAxis_144423A5BCABE67E58D2677F4102F488" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retirement Plan Sponsor Location [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetirementPlanSponsorLocationAxis" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationAxis_144423A5BCABE67E58D2677F4102F488" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RetirementPlanSponsorLocationDomain_906043C9C637EE3CC1EB677F41028DF9_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanSponsorLocationDomain_906043C9C637EE3CC1EB677F41028DF9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Sponsor Location [Domain] </link:label>
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<link:label id="lab_us-gaap_ForeignPlanMember_C9F9BC91CBB3EA4A68C0677F41024947_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignPlanMember_C9F9BC91CBB3EA4A68C0677F41024947" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> International </link:label>
<link:label id="lab_us-gaap_ForeignPlanMember_C9F9BC91CBB3EA4A68C0677F41024947_label_en-US" xlink:label="lab_us-gaap_ForeignPlanMember_C9F9BC91CBB3EA4A68C0677F41024947" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Plan [Member] </link:label>
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<link:label id="lab_us-gaap_DomesticPlanMember_FAC59C4395BBF11EE7C1677F4102231F_terseLabel_en-US" xlink:label="lab_us-gaap_DomesticPlanMember_FAC59C4395BBF11EE7C1677F4102231F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> US </link:label>
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<link:label id="lab_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_64AE0B69BE9BDF4978B9677F41039218_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_64AE0B69BE9BDF4978B9677F41039218" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of plan assets </link:label>
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<link:label id="lab_us-gaap_DefinedBenefitPlanSettlementsPlanAssets_0EF01F4BE7C61BCB008C677F41041E08_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanSettlementsPlanAssets_0EF01F4BE7C61BCB008C677F41041E08" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Settlements </link:label>
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<link:label id="lab_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_B17EC24F19FFFC68128F677F4104F0D1_totalLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_B17EC24F19FFFC68128F677F4104F0D1" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Funded status </link:label>
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<link:label id="lab_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_7C010449AA336863A6AC677F4104B8EE_label_en-US" xlink:label="lab_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_7C010449AA336863A6AC677F4104B8EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liability, Defined Benefit Plan, Current </link:label>
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<link:label id="lab_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A_terseLabel_en-US" xlink:label="lab_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Vesting [Domain] </link:label>
<link:label id="lab_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A_label_en-US" xlink:label="lab_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Vesting [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VestingDomain" xlink:label="loc_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A" xlink:to="lab_us-gaap_VestingDomain_C1C14247E74614E8FB78969D1B6D616A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheOneMember_32FDA4A36975608309EA969D1B6DD903_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheOneMember_32FDA4A36975608309EA969D1B6DD903" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Year 1 </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheOneMember_32FDA4A36975608309EA969D1B6DD903_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheOneMember_32FDA4A36975608309EA969D1B6DD903" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Award, Tranche One [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_32FDA4A36975608309EA969D1B6DD903" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Year 2 </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Award, Tranche Two [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheTwoMember" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788" xlink:to="lab_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_A1D5F0A5FDC8F95CD49F969D1B6DC788" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Year 3 </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Award, Tranche Three [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheThreeMember" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F" xlink:to="lab_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_E5E220CA1BF0EDF0CEA7969D1B6DFD8F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924_terseLabel_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share Repurchase Program [Axis] </link:label>
<link:label id="lab_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924_label_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Repurchase Program [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924" xlink:to="lab_us-gaap_ShareRepurchaseProgramAxis_42F3CB0FB0758B1826A2969D1B6D9924" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B_terseLabel_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share Repurchase Program [Domain] </link:label>
<link:label id="lab_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B_label_en-US" xlink:label="lab_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Repurchase Program [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B" xlink:to="lab_us-gaap_ShareRepurchaseProgramDomain_7CD50DAC5A5479EEDA79969D1B6D895B" xlink:type="arc"/>
<link:label id="lab_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A_terseLabel_en-US" xlink:label="lab_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> EBT </link:label>
<link:label id="lab_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A_label_en-US" xlink:label="lab_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Trust for Benefit of Employees [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TrustForBenefitOfEmployeesMember" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A" xlink:to="lab_us-gaap_TrustForBenefitOfEmployeesMember_F9F3ADD0AA017E36F433969D1B6D333A" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3_terseLabel_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:label id="lab_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3_label_en-US" xlink:label="lab_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3" xlink:to="lab_us-gaap_StatementClassOfStockAxis_6039EE06DD02678B85AD969D1B6D23A3" xlink:type="arc"/>
<link:label id="lab_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:label id="lab_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB_label_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class of Stock [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB" xlink:to="lab_us-gaap_ClassOfStockDomain_41DD3B6EB7B9A0077114969D1B6EC3CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock </link:label>
<link:label id="lab_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2_label_en-US" xlink:label="lab_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2" xlink:to="lab_us-gaap_CommonStockMember_56EADB8B7BD088185592969D1B6EEEB2" xlink:type="arc"/>
<link:label id="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4_terseLabel_en-US" xlink:label="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ADS </link:label>
<link:label id="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4_label_en-US" xlink:label="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> American Depositary Share [Member] </link:label>
<link:label id="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4_documentation_en-US" xlink:label="lab_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> An American Depositary Share ("ADS") is a vehicle for foreign corporations to list their ordinary equity on an American stock exchange, such as the New York Stock Exchange or the NASDAQ. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AmericanDepositaryShareMember" xlink:label="loc_shpgf_AmericanDepositaryShareMember_D3927BAB6D4166420FF9969D1B6EA7D4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CounterpartyNameAxis_6CE14D508E252827A36D969D1B6E9BFC_terseLabel_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_6CE14D508E252827A36D969D1B6E9BFC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:label id="lab_us-gaap_CounterpartyNameAxis_6CE14D508E252827A36D969D1B6E9BFC_label_en-US" xlink:label="lab_us-gaap_CounterpartyNameAxis_6CE14D508E252827A36D969D1B6E9BFC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_6CE14D508E252827A36D969D1B6E9BFC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_505B865C2190AB57B53B969D1B6E0C1C_terseLabel_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_505B865C2190AB57B53B969D1B6E0C1C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:label id="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_505B865C2190AB57B53B969D1B6E0C1C_label_en-US" xlink:label="lab_us-gaap_RepurchaseAgreementCounterpartyNameDomain_505B865C2190AB57B53B969D1B6E0C1C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Counterparty Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_505B865C2190AB57B53B969D1B6E0C1C" xlink:type="locator"/>
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<link:label id="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241_terseLabel_en-US" xlink:label="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxter Employees </link:label>
<link:label id="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241_label_en-US" xlink:label="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Baxter Employees [Member] </link:label>
<link:label id="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241_documentation_en-US" xlink:label="lab_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Baxter Employees [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BaxterEmployeesMember" xlink:label="loc_shpgf_BaxterEmployeesMember_EE3E5672900BED75254B969D1B6E8241" xlink:type="locator"/>
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<link:label id="lab_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Title of Individual [Axis] </link:label>
<link:label id="lab_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Title of Individual [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437" xlink:to="lab_us-gaap_TitleOfIndividualAxis_D6BB00C2F60945BBE975969D1B6E3437" xlink:type="arc"/>
<link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Relationship to Entity [Domain] </link:label>
<link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Relationship to Entity [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE" xlink:to="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_3967D6B71DED1A89B36E969D1B6EDFFE" xlink:type="arc"/>
<link:label id="lab_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06_terseLabel_en-US" xlink:label="lab_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Executive Directors </link:label>
<link:label id="lab_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06_label_en-US" xlink:label="lab_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Director [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06" xlink:to="lab_us-gaap_DirectorMember_7FFDA7F25378CCD62850969D1B6F2F06" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01_terseLabel_en-US" xlink:label="lab_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:label id="lab_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01_label_en-US" xlink:label="lab_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01" xlink:to="lab_us-gaap_RangeAxis_5C75E10CD1A1C6ECA5C8969D1B6F8F01" xlink:type="arc"/>
<link:label id="lab_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4_terseLabel_en-US" xlink:label="lab_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:label id="lab_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4_label_en-US" xlink:label="lab_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Range [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4" xlink:to="lab_us-gaap_RangeMember_CA7C68D27764D75D2FF1969D1B6F6AC4" xlink:type="arc"/>
<link:label id="lab_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309_terseLabel_en-US" xlink:label="lab_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Minimum </link:label>
<link:label id="lab_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309_label_en-US" xlink:label="lab_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Minimum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309" xlink:to="lab_us-gaap_MinimumMember_6CFFF87C8AF69F58F3A7969D1B6F3309" xlink:type="arc"/>
<link:label id="lab_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum </link:label>
<link:label id="lab_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A_label_en-US" xlink:label="lab_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Maximum [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A" xlink:to="lab_us-gaap_MaximumMember_CCA08E656AF4CCCFD7BA969D1B6FEE0A" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C_terseLabel_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:label id="lab_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C_label_en-US" xlink:label="lab_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C" xlink:to="lab_us-gaap_StatementGeographicalAxis_1E7CB6F7FBFA48E0BD55969D1B6F4D2C" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:label id="lab_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD_label_en-US" xlink:label="lab_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Geographical [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD" xlink:to="lab_us-gaap_SegmentGeographicalDomain_9DEACCDCD72FA7AB0592969D1B6FB1BD" xlink:type="arc"/>
<link:label id="lab_country_GB_6E57B2CF194E0BBC8900969D1B6F2562_terseLabel_en-US" xlink:label="lab_country_GB_6E57B2CF194E0BBC8900969D1B6F2562" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> United Kingdom </link:label>
<link:label id="lab_country_GB_6E57B2CF194E0BBC8900969D1B6F2562_label_en-US" xlink:label="lab_country_GB_6E57B2CF194E0BBC8900969D1B6F2562" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> UNITED KINGDOM </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_GB" xlink:label="loc_country_GB_6E57B2CF194E0BBC8900969D1B6F2562" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_GB_6E57B2CF194E0BBC8900969D1B6F2562" xlink:to="lab_country_GB_6E57B2CF194E0BBC8900969D1B6F2562" xlink:type="arc"/>
<link:label id="lab_country_IE_16A8E913836635A1F898969D1B70B80C_terseLabel_en-US" xlink:label="lab_country_IE_16A8E913836635A1F898969D1B70B80C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ireland </link:label>
<link:label id="lab_country_IE_16A8E913836635A1F898969D1B70B80C_label_en-US" xlink:label="lab_country_IE_16A8E913836635A1F898969D1B70B80C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> IRELAND </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_IE" xlink:label="loc_country_IE_16A8E913836635A1F898969D1B70B80C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_IE_16A8E913836635A1F898969D1B70B80C" xlink:to="lab_country_IE_16A8E913836635A1F898969D1B70B80C" xlink:type="arc"/>
<link:label id="lab_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Plan Name [Axis] </link:label>
<link:label id="lab_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633_label_en-US" xlink:label="lab_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Plan Name [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633" xlink:to="lab_us-gaap_PlanNameAxis_33CD8D10D198C5D8EF0A969D1B700633" xlink:type="arc"/>
<link:label id="lab_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Plan Name [Domain] </link:label>
<link:label id="lab_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B_label_en-US" xlink:label="lab_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Plan Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B" xlink:to="lab_us-gaap_PlanNameDomain_BFD0F24DB6AE7FF92DC1969D1B703B5B" xlink:type="arc"/>
<link:label id="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310_terseLabel_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part </link:label>
<link:label id="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310_label_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part [Member] </link:label>
<link:label id="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310_documentation_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_PortfolioSharePlanPartMember" xlink:label="loc_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:to="lab_shpgf_PortfolioSharePlanPartMember_FF2A3433F694B03A7A31969D1B704310" xlink:type="arc"/>
<link:label id="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8_terseLabel_en-US" xlink:label="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sharesave Scheme </link:label>
<link:label id="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8_label_en-US" xlink:label="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sharesave Scheme [Member] </link:label>
<link:label id="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8_documentation_en-US" xlink:label="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Sharesave Scheme [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SharesaveSchemeMember" xlink:label="loc_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:to="lab_shpgf_SharesaveSchemeMember_8A7228AA93193D4F1CFB969D1B70FBB8" xlink:type="arc"/>
<link:label id="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE_terseLabel_en-US" xlink:label="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Employee Stock Purchase Plan </link:label>
<link:label id="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE_label_en-US" xlink:label="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Employee Stock Purchase Plan [Member] </link:label>
<link:label id="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE_documentation_en-US" xlink:label="lab_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Employee Stock Purchase Plan [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_EmployeeStockPurchasePlanMember" xlink:label="loc_shpgf_EmployeeStockPurchasePlanMember_FB6BE8F6D09771067BAA969D1B70C7EE" xlink:type="locator"/>
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<link:label id="lab_shpgf_BaxaltaIncorporatedMember_690710D132BCC79B591F969D1B719FCC_terseLabel_en-US" xlink:label="lab_shpgf_BaxaltaIncorporatedMember_690710D132BCC79B591F969D1B719FCC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BaxaltaIncorporatedMember" xlink:label="loc_shpgf_BaxaltaIncorporatedMember_690710D132BCC79B591F969D1B719FCC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_BaxaltaIncorporatedMember_690710D132BCC79B591F969D1B719FCC" xlink:to="lab_shpgf_BaxaltaIncorporatedMember_690710D132BCC79B591F969D1B719FCC" xlink:type="arc"/>
<link:label id="lab_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770_terseLabel_en-US" xlink:label="lab_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Award Type [Axis] </link:label>
<link:label id="lab_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770_label_en-US" xlink:label="lab_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Award Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770" xlink:to="lab_us-gaap_AwardTypeAxis_3377945D7D0758FAADCA969D1B712770" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Award [Domain] </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Award [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19A193895E3FDCE46416969D1B71A14B" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011_terseLabel_en-US" xlink:label="lab_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> SARs </link:label>
<link:label id="lab_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011_label_en-US" xlink:label="lab_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Appreciation Rights (SARs) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockAppreciationRightsSARSMember" xlink:label="loc_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011" xlink:to="lab_us-gaap_StockAppreciationRightsSARSMember_8E54E0BD63F4EA3D3578969D1B71B011" xlink:type="arc"/>
<link:label id="lab_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899_terseLabel_en-US" xlink:label="lab_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> RSUs, PSUs and PSAs </link:label>
<link:label id="lab_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899_label_en-US" xlink:label="lab_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Performance Shares [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899" xlink:to="lab_us-gaap_PerformanceSharesMember_9D6C28C8CEE734C21223969D1B711899" xlink:type="arc"/>
<link:label id="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0_terseLabel_en-US" xlink:label="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta Replacement Award </link:label>
<link:label id="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0_label_en-US" xlink:label="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Baxalta Replacement Award [Member] </link:label>
<link:label id="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0_documentation_en-US" xlink:label="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Baxalta Replacement Award [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BaxaltaReplacementAwardMember" xlink:label="loc_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:to="lab_shpgf_BaxaltaReplacementAwardMember_5D91758BDC6274EF7A3C969D1B7163C0" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock options </link:label>
<link:label id="lab_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719_label_en-US" xlink:label="lab_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Employee Stock Option [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719" xlink:to="lab_us-gaap_EmployeeStockOptionMember_9ED60F3BE81A9A0ABB56969D1B71C719" xlink:type="arc"/>
<link:label id="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B_terseLabel_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta Replacement Options </link:label>
<link:label id="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B_label_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Replacement Awards Issued Stock Options [Member] </link:label>
<link:label id="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B_documentation_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Replacement Awards Issued Stock Options [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ReplacementAwardsIssuedStockOptionsMember" xlink:label="loc_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:to="lab_shpgf_ReplacementAwardsIssuedStockOptionsMember_CA7246AC06D245015751969D1B71A33B" xlink:type="arc"/>
<link:label id="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F_terseLabel_en-US" xlink:label="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Stock-settled SARs and stock options </link:label>
<link:label id="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F_label_en-US" xlink:label="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Appreciation Rights And Stock Options [Member] </link:label>
<link:label id="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F_documentation_en-US" xlink:label="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Stock Appreciation Rights And Stock Options [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_StockAppreciationRightsAndStockOptionsMember" xlink:label="loc_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:to="lab_shpgf_StockAppreciationRightsAndStockOptionsMember_CFD370505FCEA409D002969D1B712E7F" xlink:type="arc"/>
<link:label id="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1_terseLabel_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta Replacement RSUs </link:label>
<link:label id="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1_label_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Replacement Awards Issued Restricted Stock [Member] </link:label>
<link:label id="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1_documentation_en-US" xlink:label="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Replacement Awards Issued Restricted Stock [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ReplacementAwardsIssuedRestrictedStockMember" xlink:label="loc_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:to="lab_shpgf_ReplacementAwardsIssuedRestrictedStockMember_FE096154A804B0FDB9FC969D1B7170C1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award [Line Items] </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_C53C145F013317B6C24C969D1B723692" xlink:type="arc"/>
<link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Exercise price of common stock, percent </link:label>
<link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_2C3A8EE9155ABCF6247A969D1B7225F9" xlink:type="arc"/>
<link:label id="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4_terseLabel_en-US" xlink:label="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional holding period after vesting </link:label>
<link:label id="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4_label_en-US" xlink:label="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share Based Compensation Arrangement By Share Based Payment Award Additional Holding Period Upon Vesting </link:label>
<link:label id="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4_documentation_en-US" xlink:label="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Share Based Compensation Arrangement By Share Based Payment Award Additional Holding Period Upon Vesting </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting" xlink:label="loc_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:to="lab_shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting_488E524077A8C2A8E4CF969D1B7249B4" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D_terseLabel_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share-based compensation expense </link:label>
<link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D_label_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allocated Share-based Compensation Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D" xlink:to="lab_us-gaap_AllocatedShareBasedCompensationExpense_668305C915A43E376750969D1B72D53D" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_F8FE452CEEBD9C00E5AA969D1B724568_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_F8FE452CEEBD9C00E5AA969D1B724568" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Integration related costs </link:label>
<link:label id="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_F8FE452CEEBD9C00E5AA969D1B724568_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_F8FE452CEEBD9C00E5AA969D1B724568" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Integration Related Costs </link:label>
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<link:label id="lab_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_2BCAE37F8553C2E313769A5FCB453159_label_en-US" xlink:label="lab_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_2BCAE37F8553C2E313769A5FCB453159" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Valuation Allowances and Reserves, Additions for Charges to Cost and Expense </link:label>
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<link:label id="lab_us-gaap_ValuationAllowancesAndReservesDeductions_90DE43DF3D65F02B37009A5FCB450A78_label_en-US" xlink:label="lab_us-gaap_ValuationAllowancesAndReservesDeductions_90DE43DF3D65F02B37009A5FCB450A78" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Valuation Allowances and Reserves, Deductions </link:label>
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<link:label id="lab_us-gaap_FairValueDisclosuresAbstract_B1E6F9E11AFA3734523C4D1462FE0D4B_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract_B1E6F9E11AFA3734523C4D1462FE0D4B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Abstract] </link:label>
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<link:label id="lab_us-gaap_FairValueDisclosuresTextBlock_3433BE6AF7035D1FDADA4D1462FE734C_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresTextBlock_3433BE6AF7035D1FDADA4D1462FE734C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Disclosures [Text Block] </link:label>
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<link:label id="lab_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_DA97A9A467DCEE42D0EE2426F2300E70_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_DA97A9A467DCEE42D0EE2426F2300E70" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from External Customers by Products and Services [Table] </link:label>
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<link:label id="lab_shpgf_ImmunologyMember_253F6DAD7E269C3FFFB12426F23077DA_terseLabel_en-US" xlink:label="lab_shpgf_ImmunologyMember_253F6DAD7E269C3FFFB12426F23077DA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Immunology </link:label>
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<link:label id="lab_shpgf_ImmunoglobulinTherapiesMember_78CE892934BCC9C8D8052426F230C14F_terseLabel_en-US" xlink:label="lab_shpgf_ImmunoglobulinTherapiesMember_78CE892934BCC9C8D8052426F230C14F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> IMMUNOGLOBULIN THERAPIES </link:label>
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<link:label id="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9_terseLabel_en-US" xlink:label="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> HEREDITARY ANGIOEDEMA </link:label>
<link:label id="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9_label_en-US" xlink:label="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hereditary Angioedema [Member] </link:label>
<link:label id="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9_documentation_en-US" xlink:label="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Hereditary Angioedema [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_HereditaryAngioedemaMember" xlink:label="loc_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:to="lab_shpgf_HereditaryAngioedemaMember_9AD25AD37F3D0227FBC124ADB8D253D9" xlink:type="arc"/>
<link:label id="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3_terseLabel_en-US" xlink:label="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> BIO THERAPEUTICS </link:label>
<link:label id="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3_label_en-US" xlink:label="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> BIO THERAPEUTICS [Member] </link:label>
<link:label id="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3_documentation_en-US" xlink:label="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BioTherapeuticsMember" xlink:label="loc_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:to="lab_shpgf_BioTherapeuticsMember_6F6563309704146E585F2426F230B3F3" xlink:type="arc"/>
<link:label id="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83_terseLabel_en-US" xlink:label="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hematology </link:label>
<link:label id="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83_label_en-US" xlink:label="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hematology [Member] </link:label>
<link:label id="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83_documentation_en-US" xlink:label="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_HematologyMember" xlink:label="loc_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:to="lab_shpgf_HematologyMember_CDB2F13B64C44336D7702426F2301B83" xlink:type="arc"/>
<link:label id="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9_terseLabel_en-US" xlink:label="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> HEMOPHILIA </link:label>
<link:label id="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9_label_en-US" xlink:label="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> HEMOPHILIA [Member] </link:label>
<link:label id="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9_documentation_en-US" xlink:label="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_HemophiliaMember" xlink:label="loc_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:to="lab_shpgf_HemophiliaMember_DCF407C6D529E4E4CE062426F2301DA9" xlink:type="arc"/>
<link:label id="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A_terseLabel_en-US" xlink:label="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> INHIBITOR THERAPIES </link:label>
<link:label id="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A_label_en-US" xlink:label="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> INHIBITOR THERAPIES [Member] </link:label>
<link:label id="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A_documentation_en-US" xlink:label="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_InhibitorTherapiesMember" xlink:label="loc_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:to="lab_shpgf_InhibitorTherapiesMember_6CBE655C816DBCA32F082426F230141A" xlink:type="arc"/>
<link:label id="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013_terseLabel_en-US" xlink:label="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Neuroscience </link:label>
<link:label id="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013_label_en-US" xlink:label="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Neuroscience [Member] </link:label>
<link:label id="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013_documentation_en-US" xlink:label="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NeuroscienceMember" xlink:label="loc_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:to="lab_shpgf_NeuroscienceMember_AE56665DBEBD5AE56CAD2426F230D013" xlink:type="arc"/>
<link:label id="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA_terseLabel_en-US" xlink:label="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> VYVANSE </link:label>
<link:label id="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA_label_en-US" xlink:label="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> VYVANSE [Member] </link:label>
<link:label id="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA_documentation_en-US" xlink:label="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_VyvanseMember" xlink:label="loc_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:to="lab_shpgf_VyvanseMember_D8CA080C06DEC066525A2426F2315FDA" xlink:type="arc"/>
<link:label id="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15_terseLabel_en-US" xlink:label="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ADDERALL XR </link:label>
<link:label id="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15_label_en-US" xlink:label="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ADDERALL XR [Member] </link:label>
<link:label id="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15_documentation_en-US" xlink:label="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AdderallXrMember" xlink:label="loc_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:to="lab_shpgf_AdderallXrMember_ADC509E2977462B77A8A2426F231AC15" xlink:type="arc"/>
<link:label id="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0_terseLabel_en-US" xlink:label="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> MYDAYIS </link:label>
<link:label id="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0_label_en-US" xlink:label="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> MYDAYIS [Member] </link:label>
<link:label id="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0_documentation_en-US" xlink:label="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> MYDAYIS [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_MYDAYISMember" xlink:label="loc_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:to="lab_shpgf_MYDAYISMember_8DDB32CF2CF95E8B646F2426F2313DE0" xlink:type="arc"/>
<link:label id="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126_terseLabel_en-US" xlink:label="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Neuroscience </link:label>
<link:label id="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126_label_en-US" xlink:label="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Neuroscience [Member] </link:label>
<link:label id="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126_documentation_en-US" xlink:label="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OtherNeuroscienceMember" xlink:label="loc_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:to="lab_shpgf_OtherNeuroscienceMember_4260B360B14123DB57142426F2318126" xlink:type="arc"/>
<link:label id="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6_terseLabel_en-US" xlink:label="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Internal Medicine </link:label>
<link:label id="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6_label_en-US" xlink:label="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Internal Medicine [Member] </link:label>
<link:label id="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6_documentation_en-US" xlink:label="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_InternalMedicineMember" xlink:label="loc_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:to="lab_shpgf_InternalMedicineMember_F01101AFAB2198B9F3F62426F23754C6" xlink:type="arc"/>
<link:label id="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826_terseLabel_en-US" xlink:label="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIALDA/MEZAVANT </link:label>
<link:label id="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826_label_en-US" xlink:label="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> LIALDA and MEZAVANT [Member] </link:label>
<link:label id="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826_documentation_en-US" xlink:label="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_LialdaAndMezavantMember" xlink:label="loc_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:to="lab_shpgf_LialdaAndMezavantMember_5E30F6CBF89C9C8FB5182426F237C826" xlink:type="arc"/>
<link:label id="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530_terseLabel_en-US" xlink:label="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> GATTEX/REVESTIVE </link:label>
<link:label id="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530_label_en-US" xlink:label="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> GATTEX/REVESTIVE [Member] </link:label>
<link:label id="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530_documentation_en-US" xlink:label="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_GattexrevestiveMember" xlink:label="loc_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:to="lab_shpgf_GattexrevestiveMember_270D63AB840F7FEC40EB2426F237D530" xlink:type="arc"/>
<link:label id="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8_terseLabel_en-US" xlink:label="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> PENTASA </link:label>
<link:label id="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8_label_en-US" xlink:label="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> PENTASA [Member] </link:label>
<link:label id="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8_documentation_en-US" xlink:label="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_PentasaMember" xlink:label="loc_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:to="lab_shpgf_PentasaMember_14CEF4483A17C60F37A32426F23835E8" xlink:type="arc"/>
<link:label id="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD_verboseLabel_en-US" xlink:label="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> NATPARA/NATPAR </link:label>
<link:label id="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD_label_en-US" xlink:label="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> NATPARA/NATPAR [Member] </link:label>
<link:label id="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD_documentation_en-US" xlink:label="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NatparanatparMember" xlink:label="loc_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:to="lab_shpgf_NatparanatparMember_F709C338E8887709BA032426F238EDDD" xlink:type="arc"/>
<link:label id="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E_terseLabel_en-US" xlink:label="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Internal Medicine </link:label>
<link:label id="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E_label_en-US" xlink:label="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Internal Medicine [Member] </link:label>
<link:label id="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E_documentation_en-US" xlink:label="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OtherInternalMedicineMember" xlink:label="loc_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:to="lab_shpgf_OtherInternalMedicineMember_C5753CEBEE57B1017EF22426F2381E2E" xlink:type="arc"/>
<link:label id="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D_terseLabel_en-US" xlink:label="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Genetic Diseases </link:label>
<link:label id="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D_label_en-US" xlink:label="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Genetic Diseases [Member] </link:label>
<link:label id="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D_documentation_en-US" xlink:label="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_GeneticDiseasesMember" xlink:label="loc_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:to="lab_shpgf_GeneticDiseasesMember_B7699DCD006685C3CF952426F231646D" xlink:type="arc"/>
<link:label id="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740_terseLabel_en-US" xlink:label="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ELAPRASE </link:label>
<link:label id="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740_label_en-US" xlink:label="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> ELAPRASE [Member] </link:label>
<link:label id="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740_documentation_en-US" xlink:label="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ElapraseMember" xlink:label="loc_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:to="lab_shpgf_ElapraseMember_A605F2CD4447DD7B72C02426F2379740" xlink:type="arc"/>
<link:label id="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47_terseLabel_en-US" xlink:label="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> REPLAGAL </link:label>
<link:label id="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47_label_en-US" xlink:label="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> REPLAGAL [Member] </link:label>
<link:label id="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47_documentation_en-US" xlink:label="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ReplagalMember" xlink:label="loc_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:to="lab_shpgf_ReplagalMember_9FB595122706E5CCBAEC2426F2371F47" xlink:type="arc"/>
<link:label id="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA_terseLabel_en-US" xlink:label="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> VPRIV </link:label>
<link:label id="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA_label_en-US" xlink:label="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> VPRIV [Member] </link:label>
<link:label id="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA_documentation_en-US" xlink:label="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_VprivMember" xlink:label="loc_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:to="lab_shpgf_VprivMember_F9F5DA2F02CCACEE39622426F237C8BA" xlink:type="arc"/>
<link:label id="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E_terseLabel_en-US" xlink:label="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Oncology </link:label>
<link:label id="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E_label_en-US" xlink:label="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Oncology [Member] </link:label>
<link:label id="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E_documentation_en-US" xlink:label="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OncologyMember" xlink:label="loc_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:to="lab_shpgf_OncologyMember_2084CA3111EFEA920C702426F238019E" xlink:type="arc"/>
<link:label id="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9_terseLabel_en-US" xlink:label="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ophthalmics </link:label>
<link:label id="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9_label_en-US" xlink:label="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Opthalmology [Member] </link:label>
<link:label id="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9_documentation_en-US" xlink:label="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Opthalmology [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OpthalmologyMember" xlink:label="loc_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:to="lab_shpgf_OpthalmologyMember_0069237BBEA5CEEBBC612426F238FDF9" xlink:type="arc"/>
<link:label id="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5_terseLabel_en-US" xlink:label="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Royalties </link:label>
<link:label id="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5_label_en-US" xlink:label="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Royalty Rights [Member] </link:label>
<link:label id="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5_documentation_en-US" xlink:label="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RoyaltyRightsMember" xlink:label="loc_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:to="lab_shpgf_RoyaltyRightsMember_6E526DB375B4A68765F424B1681625C5" xlink:type="arc"/>
<link:label id="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41_terseLabel_en-US" xlink:label="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other revenues </link:label>
<link:label id="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41_label_en-US" xlink:label="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Royalties and Revenues [Member] </link:label>
<link:label id="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41_documentation_en-US" xlink:label="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OtherRoyaltiesAndRevenuesMember" xlink:label="loc_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:to="lab_shpgf_OtherRoyaltiesAndRevenuesMember_A10F98867A7C6F2850382426F238EC41" xlink:type="arc"/>
<link:label id="lab_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_D081F8B5DA99C6F026492426F2383A7E_terseLabel_en-US" xlink:label="lab_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_D081F8B5DA99C6F026492426F2383A7E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue from External Customer [Line Items] </link:label>
<link:label id="lab_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_D081F8B5DA99C6F026492426F2383A7E_label_en-US" xlink:label="lab_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_D081F8B5DA99C6F026492426F2383A7E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue from External Customer [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_D081F8B5DA99C6F026492426F2383A7E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_006E3D792313F5AD44B24D146349F402_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_006E3D792313F5AD44B24D146349F402" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discontinued Operations and Disposal Groups [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_006E3D792313F5AD44B24D146349F402" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_4DE3DD3D97968EB5D5C74D146349A561_terseLabel_en-US" xlink:label="lab_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_4DE3DD3D97968EB5D5C74D146349A561" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Results of Discontinued Operations </link:label>
<link:label id="lab_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_4DE3DD3D97968EB5D5C74D146349A561_label_en-US" xlink:label="lab_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_4DE3DD3D97968EB5D5C74D146349A561" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Disposal Groups, Including Discontinued Operations, Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_4DE3DD3D97968EB5D5C74D146349A561" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeTaxDisclosureAbstract_39920DBC1A4A2BCB2B478CC97CF2A162_label_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureAbstract_39920DBC1A4A2BCB2B478CC97CF2A162" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_39920DBC1A4A2BCB2B478CC97CF2A162" xlink:type="locator"/>
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<link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_52566F81B82376DE9E908CC97CF426BF_terseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_52566F81B82376DE9E908CC97CF426BF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income tax penalties and interest expense (credit) </link:label>
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<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_BB1285658CA7BCBA45B41F1E7A9CBA6E_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_BB1285658CA7BCBA45B41F1E7A9CBA6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Consideration Transferred </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_BB1285658CA7BCBA45B41F1E7A9CBA6E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_6821D6F98EB9D39187314319B8C3D9B8_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_6821D6F98EB9D39187314319B8C3D9B8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plans and Other Postretirement Benefit Plans Disclosures [Table] </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_6821D6F98EB9D39187314319B8C3D9B8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InvestmentTypeAxis_275B90B88A7A0D45E7114319B8C382FA_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis_275B90B88A7A0D45E7114319B8C382FA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment Type [Axis] </link:label>
<link:label id="lab_us-gaap_InvestmentTypeAxis_275B90B88A7A0D45E7114319B8C382FA_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis_275B90B88A7A0D45E7114319B8C382FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:label="loc_us-gaap_InvestmentTypeAxis_275B90B88A7A0D45E7114319B8C382FA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_D2C3E93CB5C62A3688FE4319B8C350D2_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember_D2C3E93CB5C62A3688FE4319B8C350D2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investments [Domain] </link:label>
<link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_D2C3E93CB5C62A3688FE4319B8C350D2_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember_D2C3E93CB5C62A3688FE4319B8C350D2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investments [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_D2C3E93CB5C62A3688FE4319B8C350D2" xlink:type="locator"/>
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<link:label id="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193_terseLabel_en-US" xlink:label="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collective trust funds </link:label>
<link:label id="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193_label_en-US" xlink:label="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Collective Trust Funds [Member] </link:label>
<link:label id="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193_documentation_en-US" xlink:label="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Common Collective Trust Funds [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CommonCollectiveTrustFundsMember" xlink:label="loc_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:to="lab_shpgf_CommonCollectiveTrustFundsMember_92FC3A49A04442FED6BA4319B8C34193" xlink:type="arc"/>
<link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A96D4AB3D42064CCBDF54319B8C3446C_terseLabel_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A96D4AB3D42064CCBDF54319B8C3446C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Government agency issues </link:label>
<link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A96D4AB3D42064CCBDF54319B8C3446C_label_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A96D4AB3D42064CCBDF54319B8C3446C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> US Government Agencies Debt Securities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A96D4AB3D42064CCBDF54319B8C3446C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC_terseLabel_en-US" xlink:label="lab_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Corporate bonds </link:label>
<link:label id="lab_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC_label_en-US" xlink:label="lab_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Corporate Debt Securities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC" xlink:to="lab_us-gaap_CorporateDebtSecuritiesMember_67328C32353BB6194C454319B8C353FC" xlink:type="arc"/>
<link:label id="lab_us-gaap_MutualFundMember_226743F0D4D93D74005A4319B8C3BE0E_terseLabel_en-US" xlink:label="lab_us-gaap_MutualFundMember_226743F0D4D93D74005A4319B8C3BE0E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Mutual funds </link:label>
<link:label id="lab_us-gaap_MutualFundMember_226743F0D4D93D74005A4319B8C3BE0E_label_en-US" xlink:label="lab_us-gaap_MutualFundMember_226743F0D4D93D74005A4319B8C3BE0E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Mutual Fund [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MutualFundMember" xlink:label="loc_us-gaap_MutualFundMember_226743F0D4D93D74005A4319B8C3BE0E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RealEstateFundsMember_D4F3F215C47B48019E3F4319B8C4137C_terseLabel_en-US" xlink:label="lab_us-gaap_RealEstateFundsMember_D4F3F215C47B48019E3F4319B8C4137C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Real estate funds </link:label>
<link:label id="lab_us-gaap_RealEstateFundsMember_D4F3F215C47B48019E3F4319B8C4137C_label_en-US" xlink:label="lab_us-gaap_RealEstateFundsMember_D4F3F215C47B48019E3F4319B8C4137C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Real Estate Funds [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RealEstateFundsMember" xlink:label="loc_us-gaap_RealEstateFundsMember_D4F3F215C47B48019E3F4319B8C4137C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CashAndCashEquivalentsMember_1CB8FF80D943C25A70D54319B8C40170_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsMember_1CB8FF80D943C25A70D54319B8C40170" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsMember_1CB8FF80D943C25A70D54319B8C40170_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsMember_1CB8FF80D943C25A70D54319B8C40170" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents [Member] </link:label>
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<link:label id="lab_us-gaap_CommonStockMember_8BF51211268436845CA84319B8C42E9F_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember_8BF51211268436845CA84319B8C42E9F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total common stock </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_8BF51211268436845CA84319B8C42E9F" xlink:type="locator"/>
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<link:label id="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC_terseLabel_en-US" xlink:label="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common stock - large cap </link:label>
<link:label id="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC_label_en-US" xlink:label="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Large Cap Common Stock [Member] </link:label>
<link:label id="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC_documentation_en-US" xlink:label="lab_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Large Cap Common Stock [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_LargeCapCommonStockMember" xlink:label="loc_shpgf_LargeCapCommonStockMember_4A495829A62E857246DB4319B8C403DC" xlink:type="locator"/>
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<link:label id="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2_terseLabel_en-US" xlink:label="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Mid cap </link:label>
<link:label id="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2_label_en-US" xlink:label="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Mid Cap Common Stock [Member] </link:label>
<link:label id="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2_documentation_en-US" xlink:label="lab_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Mid Cap Common Stock [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_MidCapCommonStockMember" xlink:label="loc_shpgf_MidCapCommonStockMember_6ECC6AD8D45A5D3246514319B8C456C2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_HedgeFundsMember_38B9C08CED2ED3E1EE4C4319B8C4FE33_terseLabel_en-US" xlink:label="lab_us-gaap_HedgeFundsMember_38B9C08CED2ED3E1EE4C4319B8C4FE33" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedge fund </link:label>
<link:label id="lab_us-gaap_HedgeFundsMember_38B9C08CED2ED3E1EE4C4319B8C4FE33_label_en-US" xlink:label="lab_us-gaap_HedgeFundsMember_38B9C08CED2ED3E1EE4C4319B8C4FE33" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedge Funds [Member] </link:label>
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<link:label id="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_80203E5C044A3B9D04F84DD84E72EE2C_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_80203E5C044A3B9D04F84DD84E72EE2C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Adjustments for New Accounting Pronouncements [Axis] </link:label>
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<link:label id="lab_us-gaap_TypeOfAdoptionMember_55FCAECE91A9B9C119EB4DD84E72A52A_label_en-US" xlink:label="lab_us-gaap_TypeOfAdoptionMember_55FCAECE91A9B9C119EB4DD84E72A52A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Adoption [Domain] </link:label>
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<link:label id="lab_shpgf_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember_5DC0BEFCB13F2393AF4A4DD84E72661D_terseLabel_en-US" xlink:label="lab_shpgf_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember_5DC0BEFCB13F2393AF4A4DD84E72661D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounting Standards Update 2016-09, Excess Tax Benefit Component </link:label>
<link:label id="lab_shpgf_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember_5DC0BEFCB13F2393AF4A4DD84E72661D_label_en-US" xlink:label="lab_shpgf_AccountingStandardsUpdate201609ExcessTaxBenefitComponentMember_5DC0BEFCB13F2393AF4A4DD84E72661D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Standards Update 2016-09, Excess Tax Benefit Component [Member] </link:label>
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<link:label id="lab_shpgf_AccountingStandardsUpdate201609ForfeitureRateComponentMember_3139DE78F14A9B2698CE4DD84E73162D_terseLabel_en-US" xlink:label="lab_shpgf_AccountingStandardsUpdate201609ForfeitureRateComponentMember_3139DE78F14A9B2698CE4DD84E73162D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounting Standards Update 2016-09, Forfeiture Rate Component </link:label>
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<link:label id="lab_shpgf_AccountingStandardsUpdate201609ForfeitureRateComponentMember_3139DE78F14A9B2698CE4DD84E73162D_documentation_en-US" xlink:label="lab_shpgf_AccountingStandardsUpdate201609ForfeitureRateComponentMember_3139DE78F14A9B2698CE4DD84E73162D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accounting Standards Update 2016-09, Forfeiture Rate Component [Member] </link:label>
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<link:label id="lab_us-gaap_StatementEquityComponentsAxis_65B2D09853CA1C9EEC694DD84E73E7C7_terseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_65B2D09853CA1C9EEC694DD84E73E7C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
<link:label id="lab_us-gaap_StatementEquityComponentsAxis_65B2D09853CA1C9EEC694DD84E73E7C7_label_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis_65B2D09853CA1C9EEC694DD84E73E7C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Components [Axis] </link:label>
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<link:label id="lab_us-gaap_EquityComponentDomain_46DBFF70E90598A6CA274DD84E738CB7_label_en-US" xlink:label="lab_us-gaap_EquityComponentDomain_46DBFF70E90598A6CA274DD84E738CB7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Equity Component [Domain] </link:label>
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<link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_AACD21C34FA0EAA057D24DD84E733852_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember_AACD21C34FA0EAA057D24DD84E733852" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Additional paid-in capital </link:label>
<link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_AACD21C34FA0EAA057D24DD84E733852_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember_AACD21C34FA0EAA057D24DD84E733852" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Additional Paid-in Capital [Member] </link:label>
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<link:label id="lab_us-gaap_RetainedEarningsMember_318A624973DA4FB14B084DD84E734B29_terseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember_318A624973DA4FB14B084DD84E734B29" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retained earnings </link:label>
<link:label id="lab_us-gaap_RetainedEarningsMember_318A624973DA4FB14B084DD84E734B29_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember_318A624973DA4FB14B084DD84E734B29" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retained Earnings [Member] </link:label>
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<link:label id="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_CDBA3563080AB89083D64DD84E7335DE_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_CDBA3563080AB89083D64DD84E7335DE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements or Change in Accounting Principle [Line Items] </link:label>
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<link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_055CB54C6E7D2B45526E4DD84E73ABE9_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1_055CB54C6E7D2B45526E4DD84E73ABE9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of purchase consideration </link:label>
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<link:label id="lab_us-gaap_OtherLongTermDebtCurrent_3E592FBAC7E12BE38E84768D02840ED2_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLongTermDebtCurrent_3E592FBAC7E12BE38E84768D02840ED2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other borrowings </link:label>
<link:label id="lab_us-gaap_OtherLongTermDebtCurrent_3E592FBAC7E12BE38E84768D02840ED2_label_en-US" xlink:label="lab_us-gaap_OtherLongTermDebtCurrent_3E592FBAC7E12BE38E84768D02840ED2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Long-term Debt, Current </link:label>
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<link:label id="lab_us-gaap_DebtCurrent_05A7A084E7A55E92D232768D0284C6C2_totalLabel_en-US" xlink:label="lab_us-gaap_DebtCurrent_05A7A084E7A55E92D232768D0284C6C2" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Short-term Debt, Total </link:label>
<link:label id="lab_us-gaap_DebtCurrent_05A7A084E7A55E92D232768D0284C6C2_label_en-US" xlink:label="lab_us-gaap_DebtCurrent_05A7A084E7A55E92D232768D0284C6C2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt, Current </link:label>
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<link:label id="lab_us-gaap_OtherCurrentLiabilitiesTableTextBlock_3D289A616B658CC71F35E180FECED91B_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCurrentLiabilitiesTableTextBlock_3D289A616B658CC71F35E180FECED91B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Current Liabilities </link:label>
<link:label id="lab_us-gaap_OtherCurrentLiabilitiesTableTextBlock_3D289A616B658CC71F35E180FECED91B_label_en-US" xlink:label="lab_us-gaap_OtherCurrentLiabilitiesTableTextBlock_3D289A616B658CC71F35E180FECED91B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Current Liabilities [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCurrentLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesTableTextBlock_3D289A616B658CC71F35E180FECED91B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_FBD7421A596388C2961AC417F2B7C630_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D963EFBC4F04532898B1807B2106D411" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_FBD7421A596388C2961AC417F2B7C630_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D963EFBC4F04532898B1807B2106D411" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements, Recurring and Nonrecurring [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D963EFBC4F04532898B1807B2106D411" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_F3D95523F22B6A4395ACC417F2B891F5_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_D6BD745607605EDD94F58863BC986649" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Measurement Basis [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementBasisAxis_F3D95523F22B6A4395ACC417F2B891F5_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementBasisAxis_D6BD745607605EDD94F58863BC986649" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Basis [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_D6BD745607605EDD94F58863BC986649" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_9794A6DEB8E5693CF100C417F2B81B14_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_43C6C0D4C3F75303AF9525DDBD365D7F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_9794A6DEB8E5693CF100C417F2B81B14_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain_43C6C0D4C3F75303AF9525DDBD365D7F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_43C6C0D4C3F75303AF9525DDBD365D7F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_13FA12512D303ECAB894C417F2B8DE02_terseLabel_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_078B9F88D4BC5C8EBC39ACEDBD8B0422" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement [Member] </link:label>
<link:label id="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_13FA12512D303ECAB894C417F2B8DE02_label_en-US" xlink:label="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_078B9F88D4BC5C8EBC39ACEDBD8B0422" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Portion at Fair Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_078B9F88D4BC5C8EBC39ACEDBD8B0422" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_078B9F88D4BC5C8EBC39ACEDBD8B0422" xlink:to="lab_us-gaap_PortionAtFairValueFairValueDisclosureMember_078B9F88D4BC5C8EBC39ACEDBD8B0422" xlink:type="arc"/>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_FCCD0B4A6CD395E9A410C417F2B9BB3E_terseLabel_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_9643A0DBFE7756DA997EEC25CA16D4F7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Carrying amount </link:label>
<link:label id="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_FCCD0B4A6CD395E9A410C417F2B9BB3E_label_en-US" xlink:label="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_9643A0DBFE7756DA997EEC25CA16D4F7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Reported Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_9643A0DBFE7756DA997EEC25CA16D4F7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_9643A0DBFE7756DA997EEC25CA16D4F7" xlink:to="lab_us-gaap_CarryingReportedAmountFairValueDisclosureMember_9643A0DBFE7756DA997EEC25CA16D4F7" xlink:type="arc"/>
<link:label id="lab_us-gaap_EstimateOfFairValueFairValueDisclosureMember_878375238BFEE1D2D242C417F2B98881_terseLabel_en-US" xlink:label="lab_us-gaap_EstimateOfFairValueFairValueDisclosureMember_3959BA31D64E5E76B787D5F9D2B9C487" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value </link:label>
<link:label id="lab_us-gaap_EstimateOfFairValueFairValueDisclosureMember_878375238BFEE1D2D242C417F2B98881_label_en-US" xlink:label="lab_us-gaap_EstimateOfFairValueFairValueDisclosureMember_3959BA31D64E5E76B787D5F9D2B9C487" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Estimate of Fair Value Measurement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_3959BA31D64E5E76B787D5F9D2B9C487" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_B2232FAF0C471D8A7E47C417F2B9A576_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_9FA85348F0BF5695AF21978767771B25" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_B2232FAF0C471D8A7E47C417F2B9A576_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis_9FA85348F0BF5695AF21978767771B25" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Measurement Frequency [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_9FA85348F0BF5695AF21978767771B25" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_FE7F471EE40612605999C417F2B97825_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_15F0D14762345C3494A2CE1DB242C66C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_FE7F471EE40612605999C417F2B97825_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain_15F0D14762345C3494A2CE1DB242C66C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement Frequency [Domain] </link:label>
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<link:label id="lab_us-gaap_FairValueMeasurementsNonrecurringMember_BCB8C4765D3FD6CC59C8C417F2B9BA13_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsNonrecurringMember_6476928FFE0452199283B87A0C6A6591" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Nonrecurring Basis </link:label>
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<link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1BAFFCA0F625F895D090C417F2B9B46A_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1F0FA68558305AC5920A0E85D35542C1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] </link:label>
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<link:label id="lab_us-gaap_LongTermDebtFairValue_AB1231FBE57A5EE74F60C417F2B9D5C9_label_en-US" xlink:label="lab_us-gaap_LongTermDebtFairValue_13AA5DA356505E5AA0713C5ACABFBA15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Fair Value </link:label>
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<link:label id="lab_shpgf_LongTermTaxRelatedIndemnificationLiabilities_3F85DC124CF3E2EB11EE4DD9A6AAEF93_terseLabel_en-US" xlink:label="lab_shpgf_LongTermTaxRelatedIndemnificationLiabilities_3F85DC124CF3E2EB11EE4DD9A6AAEF93" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other non-current liabilities </link:label>
<link:label id="lab_shpgf_LongTermTaxRelatedIndemnificationLiabilities_3F85DC124CF3E2EB11EE4DD9A6AAEF93_label_en-US" xlink:label="lab_shpgf_LongTermTaxRelatedIndemnificationLiabilities_3F85DC124CF3E2EB11EE4DD9A6AAEF93" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long Term Tax Related Indemnification Liabilities </link:label>
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<link:label id="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationTable_19D38D5AAB036A42D9822F643BD3B34B_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationTable_ABBB84D0B24650ACAFA59F04C4A23F31" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Liabilities, Quantitative Information [Table] </link:label>
<link:label id="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationTable_19D38D5AAB036A42D9822F643BD3B34B_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationTable_ABBB84D0B24650ACAFA59F04C4A23F31" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Liabilities, Quantitative Information [Table] </link:label>
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<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_039A1D4019AFCB3F5B562F643BD30712_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_B7177E0E488E52409692E1BC71C5AF3E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Recurring Basis </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_039A1D4019AFCB3F5B562F643BD30712_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember_B7177E0E488E52409692E1BC71C5AF3E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurements, Recurring [Member] </link:label>
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<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_963AA1BCBAE0E3CB06C02F643BD3EE57_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_417954A3B2505F5799A64BA9EC88CB6E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
<link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_963AA1BCBAE0E3CB06C02F643BD3EE57_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis_417954A3B2505F5799A64BA9EC88CB6E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liability Class [Axis] </link:label>
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<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_DA73CBD92E60949086AB2F643BD3C88F_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_C186A4EA58755687ADF047C637E22160" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_DA73CBD92E60949086AB2F643BD3C88F_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_C186A4EA58755687ADF047C637E22160" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value by Liability Class [Domain] </link:label>
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<link:label id="lab_shpgf_ContingentConsiderationPayableMember_27AEF5A02B55A6FA1A982F643BD313E7_terseLabel_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableMember_CA2ED927AC065D008DC0C389AD5141F5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent Consideration Payable </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableMember_27AEF5A02B55A6FA1A982F643BD313E7_label_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableMember_CA2ED927AC065D008DC0C389AD5141F5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration Payable [Member] </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableMember_27AEF5A02B55A6FA1A982F643BD313E7_documentation_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableMember_CA2ED927AC065D008DC0C389AD5141F5" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ContingentConsiderationPayableMember" xlink:label="loc_shpgf_ContingentConsiderationPayableMember_CA2ED927AC065D008DC0C389AD5141F5" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_BED12B0B82AAC56CCAF22F643BD38769_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_F565FC1CFB295D80AC00DFC62D9344D8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative Financial Instruments, Liabilities </link:label>
<link:label id="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_BED12B0B82AAC56CCAF22F643BD38769_label_en-US" xlink:label="lab_us-gaap_DerivativeFinancialInstrumentsLiabilitiesMember_F565FC1CFB295D80AC00DFC62D9344D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Financial Instruments, Liabilities [Member] </link:label>
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<link:label id="lab_us-gaap_ValuationTechniqueAxis_A5C6FB12C6D148152C9D2F643BD38F5E_terseLabel_en-US" xlink:label="lab_us-gaap_ValuationTechniqueAxis_342620B343815BC69ED956E219E73CC7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Valuation Technique [Axis] </link:label>
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<link:label id="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_BD026FA55ABFA6381BCE2F643BD3C7C8_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_D1897CD7A9A25F228622E2FFB73783D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Liabilities, Quantitative Information [Line Items] </link:label>
<link:label id="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_BD026FA55ABFA6381BCE2F643BD3C7C8_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_D1897CD7A9A25F228622E2FFB73783D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Liabilities, Quantitative Information [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems" xlink:label="loc_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_D1897CD7A9A25F228622E2FFB73783D4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_D1897CD7A9A25F228622E2FFB73783D4" xlink:to="lab_us-gaap_FairValueInputsLiabilitiesQuantitativeInformationLineItems_D1897CD7A9A25F228622E2FFB73783D4" xlink:type="arc"/>
<link:label id="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_FB142E38BCCEBF1421B12F643BD3E0D8_terseLabel_en-US" xlink:label="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cumulative probability of milestones being achieved (in percent) </link:label>
<link:label id="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_FB142E38BCCEBF1421B12F643BD3E0D8_label_en-US" xlink:label="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Cumulative Probability of Milestones Being Achieved </link:label>
<link:label id="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_FB142E38BCCEBF1421B12F643BD3E0D8_documentation_en-US" xlink:label="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cumulative probability of milestones being achieved, used as an input to measure fair value. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved" xlink:label="loc_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:to="lab_shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved_06C1439CB7F65EFDBBF335D973758B4B" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_43194791102DF8C42AB12F643BD3E8F1_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_0269510681B45BF0A59C36D5334FC9CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_43194791102DF8C42AB12F643BD3E8F1_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure_0269510681B45BF0A59C36D5334FC9CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial and Nonfinancial Liabilities, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_0269510681B45BF0A59C36D5334FC9CB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_0269510681B45BF0A59C36D5334FC9CB" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure_0269510681B45BF0A59C36D5334FC9CB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLiabilities_E41E321D90C2F852EB5F2F643BD35AA6_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_06FCD0B30EB852A198066AAA3D00F9A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Joint venture net written option </link:label>
<link:label id="lab_us-gaap_DerivativeLiabilities_E41E321D90C2F852EB5F2F643BD35AA6_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_06FCD0B30EB852A198066AAA3D00F9A4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_06FCD0B30EB852A198066AAA3D00F9A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilities_06FCD0B30EB852A198066AAA3D00F9A4" xlink:to="lab_us-gaap_DerivativeLiabilities_06FCD0B30EB852A198066AAA3D00F9A4" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsDiscountForLackOfMarketability_295DBD3B6863167CA7E82F643BD301B9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountForLackOfMarketability_D32096559456563DBC68A73C1620FCB6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assumed market participant discount rate </link:label>
<link:label id="lab_us-gaap_FairValueInputsDiscountForLackOfMarketability_295DBD3B6863167CA7E82F643BD301B9_label_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountForLackOfMarketability_D32096559456563DBC68A73C1620FCB6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Discount for Lack of Marketability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsDiscountForLackOfMarketability" xlink:label="loc_us-gaap_FairValueInputsDiscountForLackOfMarketability_D32096559456563DBC68A73C1620FCB6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsDiscountForLackOfMarketability_D32096559456563DBC68A73C1620FCB6" xlink:to="lab_us-gaap_FairValueInputsDiscountForLackOfMarketability_D32096559456563DBC68A73C1620FCB6" xlink:type="arc"/>
<link:label id="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_CEC247AD489734AA14BC2F643BD346C9_terseLabel_en-US" xlink:label="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Periods in which milestones are expected to be achieved </link:label>
<link:label id="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_CEC247AD489734AA14BC2F643BD346C9_label_en-US" xlink:label="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Periods in Which Milestones are Expected to Be Achieved </link:label>
<link:label id="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_CEC247AD489734AA14BC2F643BD346C9_documentation_en-US" xlink:label="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Periods in which milestones are expected to be achieved, used as an input to measure fair value. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved" xlink:label="loc_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:to="lab_shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved_0AF0BCD047765ED393250793EDAC2606" xlink:type="arc"/>
<link:label id="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_BCDB6C19AD981E9876812F643BD3CEB9_terseLabel_en-US" xlink:label="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Forecast quarterly royalties payable on net sales of relevant products </link:label>
<link:label id="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_BCDB6C19AD981E9876812F643BD3CEB9_label_en-US" xlink:label="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Estimated Quarterly Royalties Payable on Net Sales of Relevant Products </link:label>
<link:label id="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_BCDB6C19AD981E9876812F643BD3CEB9_documentation_en-US" xlink:label="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Estimated quarterly royalties payable on net sales of relevant products, used as an input to measure fair value. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts" xlink:label="loc_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:to="lab_shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts_B18AD1BA72DD5934870E06D5D3BC74F3" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsProbabilityOfDefault_A4172511B1D7128266222F643BD3C7E5_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsProbabilityOfDefault_32F3525FC4CB57709563C5A6F528B55F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash flow scenario probability weighting </link:label>
<link:label id="lab_us-gaap_FairValueInputsProbabilityOfDefault_A4172511B1D7128266222F643BD3C7E5_label_en-US" xlink:label="lab_us-gaap_FairValueInputsProbabilityOfDefault_32F3525FC4CB57709563C5A6F528B55F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Probability of Default </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsProbabilityOfDefault" xlink:label="loc_us-gaap_FairValueInputsProbabilityOfDefault_32F3525FC4CB57709563C5A6F528B55F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsProbabilityOfDefault_32F3525FC4CB57709563C5A6F528B55F" xlink:to="lab_us-gaap_FairValueInputsProbabilityOfDefault_32F3525FC4CB57709563C5A6F528B55F" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueInputsDiscountRate_1E5EF5C41A0D81C3B9EA2F643BD30AAC_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountRate_11ED8F00BB0055A2A0D237171B3A8CCD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assumed market participant discount rate </link:label>
<link:label id="lab_us-gaap_FairValueInputsDiscountRate_1E5EF5C41A0D81C3B9EA2F643BD30AAC_label_en-US" xlink:label="lab_us-gaap_FairValueInputsDiscountRate_11ED8F00BB0055A2A0D237171B3A8CCD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Inputs, Discount Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_11ED8F00BB0055A2A0D237171B3A8CCD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsDiscountRate_11ED8F00BB0055A2A0D237171B3A8CCD" xlink:to="lab_us-gaap_FairValueInputsDiscountRate_11ED8F00BB0055A2A0D237171B3A8CCD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2018 </link:label>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583" xlink:to="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_AEC556FC2178E3CD1C0C4DD9A91B0583" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2019 </link:label>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal in Year Two </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71" xlink:to="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_0E9A675B07BD838030714DD9A91B8D71" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2020 </link:label>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal in Year Three </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F" xlink:to="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5596D3553CA54389BE434DD9A91BC60F" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2021 </link:label>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal in Year Four </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582" xlink:to="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_51EAC45E693C7BA3339D4DD9A91B2582" xlink:type="arc"/>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_2DFC0345F9F33FD449094DD9A91B01EB_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_2DFC0345F9F33FD449094DD9A91B01EB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2022 </link:label>
<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_2DFC0345F9F33FD449094DD9A91B01EB_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_2DFC0345F9F33FD449094DD9A91B01EB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal in Year Five </link:label>
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<link:label id="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_1C03910AFAA773DDE7B34DD9A91C11ED_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_1C03910AFAA773DDE7B34DD9A91C11ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Maturities, Repayments of Principal after Year Five </link:label>
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<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_204D7A6344A7D45311384DD9A91C5536_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_204D7A6344A7D45311384DD9A91C5536" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt, Gross </link:label>
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<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_B73B54AC95672E8ECDA74DD9A91C1BE4_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_B73B54AC95672E8ECDA74DD9A91C1BE4" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Less: Debt issuance cost and discount </link:label>
<link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_B73B54AC95672E8ECDA74DD9A91C1BE4_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_B73B54AC95672E8ECDA74DD9A91C1BE4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net </link:label>
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<link:label id="lab_us-gaap_DebtAndCapitalLeaseObligations_5F3AFC31265649B003424DD9A91C3D84_totalLabel_en-US" xlink:label="lab_us-gaap_DebtAndCapitalLeaseObligations_5F3AFC31265649B003424DD9A91C3D84" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total debt obligations </link:label>
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<link:label id="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B_terseLabel_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part B </link:label>
<link:label id="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B_label_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part B [Member] </link:label>
<link:label id="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B_documentation_en-US" xlink:label="lab_shpgf_PortfolioSharePlanPartBMember_AA7821B32D375BD06ABA787DDC1F4A6B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Portfolio Share Plan Part B [Member] </link:label>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_204EE6C5EC929B1B7C11787DDC1F94A8_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_204EE6C5EC929B1B7C11787DDC1F94A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of awards (in shares) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_204EE6C5EC929B1B7C11787DDC1F94A8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_9D46AA0C4DA4BAB391AD787DDC1FF5DB_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_9D46AA0C4DA4BAB391AD787DDC1FF5DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expiration period from date of issue </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_9D46AA0C4DA4BAB391AD787DDC1FF5DB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentAbstract_F0CADD95D3C18B686C6F2F643C507481_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentAbstract_D01398A2E41E5C959370C397E0693B23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_D01398A2E41E5C959370C397E0693B23" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTextBlock_712BD754C9880F7DDEE22F643C505F77_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTextBlock_0CE86754EBC058F49CBF8B917A64E49E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_7684697434B2F86C72D14D14648908D0_label_en-US" xlink:label="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_7684697434B2F86C72D14D14648908D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Comprehensive Income [Abstract] </link:label>
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<link:label id="lab_us-gaap_NetIncomeLoss_9BB0F8712D89647904AD4D1464899D1F_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_9BB0F8712D89647904AD4D1464899D1F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_59B2E65C531CBE710C784D14648A4478_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_59B2E65C531CBE710C784D14648A4478" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income/(loss): </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3825B35A338B114FEAC04D14648A6368_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3825B35A338B114FEAC04D14648A6368" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency translation adjustments </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3825B35A338B114FEAC04D14648A6368_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3825B35A338B114FEAC04D14648A6368" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_9C621E1381379450C7E14D14648AB2FC_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_9C621E1381379450C7E14D14648AB2FC" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Pension and other employee benefits (net of tax expense of $11.2 million, $8.8 million and $nil for the years ended December 31, 2017, 2016 and 2015, respectively) </link:label>
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<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_2020A41AB8999A4D334424A434282020_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_2020A41AB8999A4D334424A434282020" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_2020A41AB8999A4D334424A434282020_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis_2020A41AB8999A4D334424A434282020" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_2020A41AB8999A4D334424A434282020" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_BE3957A510B1C054AAF724A483A06D1D_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_BE3957A510B1C054AAF724A483A06D1D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_BE3957A510B1C054AAF724A483A06D1D_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain_BE3957A510B1C054AAF724A483A06D1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_BE3957A510B1C054AAF724A483A06D1D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_2991FCC4894A639F05E124A4C4E2582A_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_2991FCC4894A639F05E124A4C4E2582A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk </link:label>
<link:label id="lab_us-gaap_CustomerConcentrationRiskMember_2991FCC4894A639F05E124A4C4E2582A_label_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember_2991FCC4894A639F05E124A4C4E2582A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer Concentration Risk [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_2991FCC4894A639F05E124A4C4E2582A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_MajorCustomersAxis_E26D674963D4306B007024A406955498_terseLabel_en-US" xlink:label="lab_us-gaap_MajorCustomersAxis_E26D674963D4306B007024A406955498" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer [Axis] </link:label>
<link:label id="lab_us-gaap_MajorCustomersAxis_E26D674963D4306B007024A406955498_label_en-US" xlink:label="lab_us-gaap_MajorCustomersAxis_E26D674963D4306B007024A406955498" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="loc_us-gaap_MajorCustomersAxis_E26D674963D4306B007024A406955498" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NameOfMajorCustomerDomain_B8D7806E96A34485567824A406A80137_terseLabel_en-US" xlink:label="lab_us-gaap_NameOfMajorCustomerDomain_B8D7806E96A34485567824A406A80137" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Customer [Domain] </link:label>
<link:label id="lab_us-gaap_NameOfMajorCustomerDomain_B8D7806E96A34485567824A406A80137_label_en-US" xlink:label="lab_us-gaap_NameOfMajorCustomerDomain_B8D7806E96A34485567824A406A80137" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Customer [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="loc_us-gaap_NameOfMajorCustomerDomain_B8D7806E96A34485567824A406A80137" xlink:type="locator"/>
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<link:label id="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE_terseLabel_en-US" xlink:label="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> AmerisourceBergen Corp </link:label>
<link:label id="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE_label_en-US" xlink:label="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amerisource Bergen Corp [Member] </link:label>
<link:label id="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE_documentation_en-US" xlink:label="lab_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Amerisource Bergen Corp [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AmerisourceBergenCorpMember" xlink:label="loc_shpgf_AmerisourceBergenCorpMember_80316DC8EA762429B0F124A5563DEDFE" xlink:type="locator"/>
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<link:label id="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF_terseLabel_en-US" xlink:label="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> McKesson Corp. </link:label>
<link:label id="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF_label_en-US" xlink:label="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> McKesson Corp [Member] </link:label>
<link:label id="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF_documentation_en-US" xlink:label="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> McKesson Corp [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_McKessonCorpMember" xlink:label="loc_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:to="lab_shpgf_McKessonCorpMember_B33C10928835700C3D6024A5AE1810AF" xlink:type="arc"/>
<link:label id="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94_terseLabel_en-US" xlink:label="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cardinal Health Inc. </link:label>
<link:label id="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94_label_en-US" xlink:label="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cardinal Health Inc [Member] </link:label>
<link:label id="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94_documentation_en-US" xlink:label="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Cardinal Health Inc [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CardinalHealthIncMember" xlink:label="loc_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:to="lab_shpgf_CardinalHealthIncMember_CDBB6D9CC629206121C724A60383BF94" xlink:type="arc"/>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_686452404B13D9C7FA0C24A33884CA21_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_686452404B13D9C7FA0C24A33884CA21" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:label id="lab_us-gaap_SegmentReportingInformationLineItems_686452404B13D9C7FA0C24A33884CA21_label_en-US" xlink:label="lab_us-gaap_SegmentReportingInformationLineItems_686452404B13D9C7FA0C24A33884CA21" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Information [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_686452404B13D9C7FA0C24A33884CA21" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_9F1722DEFB92C3FC8AEA24A3BC904839_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_9F1722DEFB92C3FC8AEA24A3BC904839" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> % Product sales </link:label>
<link:label id="lab_us-gaap_ConcentrationRiskPercentage1_9F1722DEFB92C3FC8AEA24A3BC904839_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1_9F1722DEFB92C3FC8AEA24A3BC904839" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Concentration Risk, Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_9F1722DEFB92C3FC8AEA24A3BC904839" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccountsReceivableNet_669D0A59D68EEEE1589724A7D7ECCAE9_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNet_669D0A59D68EEEE1589724A7D7ECCAE9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amounts outstanding </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNet_669D0A59D68EEEE1589724A7D7ECCAE9_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNet_669D0A59D68EEEE1589724A7D7ECCAE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsReceivableNet" xlink:label="loc_us-gaap_AccountsReceivableNet_669D0A59D68EEEE1589724A7D7ECCAE9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_CE3B71AB254CE1BA35512F643BF2F11C_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_BA7E7BB996665B52917C675D9FD3655D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Summary of Employee Termination Related Reserve and Other </link:label>
<link:label id="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_CE3B71AB254CE1BA35512F643BF2F11C_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_BA7E7BB996665B52917C675D9FD3655D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring and Related Costs [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_PrepaidExpenseCurrent_CC5EABEECF3F0AA2E6A195BB3F44C347_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseCurrent_CC5EABEECF3F0AA2E6A195BB3F44C347" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses </link:label>
<link:label id="lab_us-gaap_PrepaidExpenseCurrent_CC5EABEECF3F0AA2E6A195BB3F44C347_label_en-US" xlink:label="lab_us-gaap_PrepaidExpenseCurrent_CC5EABEECF3F0AA2E6A195BB3F44C347" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expense, Current </link:label>
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<link:label id="lab_us-gaap_IncomeTaxReceivable_AF16DA773E37932A425495BB3F417E9E_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReceivable_AF16DA773E37932A425495BB3F417E9E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income tax receivable </link:label>
<link:label id="lab_us-gaap_IncomeTaxReceivable_AF16DA773E37932A425495BB3F417E9E_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReceivable_AF16DA773E37932A425495BB3F417E9E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Taxes Receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxReceivable" xlink:label="loc_us-gaap_IncomeTaxReceivable_AF16DA773E37932A425495BB3F417E9E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InventoryFinishedGoodsNetOfReserves_2EB8D8D2D817DE880E6B2F643A3B620F_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoodsNetOfReserves_38F52C455FBC59B990DA85E9113C8111" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finished goods </link:label>
<link:label id="lab_us-gaap_InventoryFinishedGoodsNetOfReserves_2EB8D8D2D817DE880E6B2F643A3B620F_label_en-US" xlink:label="lab_us-gaap_InventoryFinishedGoodsNetOfReserves_38F52C455FBC59B990DA85E9113C8111" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Finished Goods, Net of Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_38F52C455FBC59B990DA85E9113C8111" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InventoryWorkInProcessNetOfReserves_96C2752362BA73438D702F643A3B4DF8_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcessNetOfReserves_CA1AEA7E32FE5C1DB6D5A03E6C17E4F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Work-in-progress </link:label>
<link:label id="lab_us-gaap_InventoryWorkInProcessNetOfReserves_96C2752362BA73438D702F643A3B4DF8_label_en-US" xlink:label="lab_us-gaap_InventoryWorkInProcessNetOfReserves_CA1AEA7E32FE5C1DB6D5A03E6C17E4F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Work in Process, Net of Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_CA1AEA7E32FE5C1DB6D5A03E6C17E4F9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InventoryRawMaterialsNetOfReserves_ECDD2EC458FA1FEABDF52F643A3B0B9F_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryRawMaterialsNetOfReserves_77B58DF57A0553F5A89A7EC9EAEC09A0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Raw materials </link:label>
<link:label id="lab_us-gaap_InventoryRawMaterialsNetOfReserves_ECDD2EC458FA1FEABDF52F643A3B0B9F_label_en-US" xlink:label="lab_us-gaap_InventoryRawMaterialsNetOfReserves_77B58DF57A0553F5A89A7EC9EAEC09A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Raw Materials, Net of Reserves </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_77B58DF57A0553F5A89A7EC9EAEC09A0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_InventoryNet_EABE4BB50BFC82E3DA9C2F643A3B509F_totalLabel_en-US" xlink:label="lab_us-gaap_InventoryNet_2E22D14A167D5E168AA29C96CCC02858" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total inventories </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_2E22D14A167D5E168AA29C96CCC02858" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_AB9E2E9ECFF858A5F6DB1F1E79E6147C_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_AB9E2E9ECFF858A5F6DB1F1E79E6147C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets, Net (Excluding Goodwill) [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_AB9E2E9ECFF858A5F6DB1F1E79E6147C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_4822165046EC2E924E471F1E79E68236_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_4822165046EC2E924E471F1E79E68236" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2018 </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_4822165046EC2E924E471F1E79E68236_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_4822165046EC2E924E471F1E79E68236" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Amortization Expense, Year Two </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_4822165046EC2E924E471F1E79E68236" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2019 </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Amortization Expense, Year Three </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3E70D374ECC74FE2C8531F1E79E60951" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2020 </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Amortization Expense, Year Four </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_6A7087FC7884CD4B8BEE1F1E79E6450A" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2021 </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Amortization Expense, Year Five </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_18736F11B645D55792ED1F1E79E64F59" xlink:type="arc"/>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_9545A3BB0AA8DA3C88BD1F1E79E64DEA_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_9545A3BB0AA8DA3C88BD1F1E79E64DEA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2022 </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_9545A3BB0AA8DA3C88BD1F1E79E64DEA_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_9545A3BB0AA8DA3C88BD1F1E79E64DEA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Amortization Expense, after Year Five </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_9545A3BB0AA8DA3C88BD1F1E79E64DEA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNetAbstract_6A32CC3F8261B574241A4DD9A9A6BFC0_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNetAbstract_6A32CC3F8261B574241A4DD9A9A6BFC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNetAbstract_6A32CC3F8261B574241A4DD9A9A6BFC0_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNetAbstract_6A32CC3F8261B574241A4DD9A9A6BFC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net [Abstract] </link:label>
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<link:label id="lab_us-gaap_Land_A4369316808FEE7E75D44DF14FB007BA_terseLabel_en-US" xlink:label="lab_us-gaap_Land_A4369316808FEE7E75D44DF14FB007BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Land </link:label>
<link:label id="lab_us-gaap_Land_A4369316808FEE7E75D44DF14FB007BA_label_en-US" xlink:label="lab_us-gaap_Land_A4369316808FEE7E75D44DF14FB007BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Land </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Land" xlink:label="loc_us-gaap_Land_A4369316808FEE7E75D44DF14FB007BA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FurnitureAndFixturesGross_7939252AB03A77B188D74DD9A9A68DC8_terseLabel_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesGross_7939252AB03A77B188D74DD9A9A68DC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Buildings and leasehold improvements </link:label>
<link:label id="lab_us-gaap_FurnitureAndFixturesGross_7939252AB03A77B188D74DD9A9A68DC8_label_en-US" xlink:label="lab_us-gaap_FurnitureAndFixturesGross_7939252AB03A77B188D74DD9A9A68DC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Furniture and Fixtures, Gross </link:label>
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<link:label id="lab_us-gaap_MachineryAndEquipmentGross_CDC9B9B6D24961B4222A4DD9A9A66A1D_verboseLabel_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentGross_CDC9B9B6D24961B4222A4DD9A9A66A1D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Machinery, equipment and other </link:label>
<link:label id="lab_us-gaap_MachineryAndEquipmentGross_CDC9B9B6D24961B4222A4DD9A9A66A1D_label_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentGross_CDC9B9B6D24961B4222A4DD9A9A66A1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Machinery and Equipment, Gross </link:label>
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<link:label id="lab_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59_terseLabel_en-US" xlink:label="lab_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assets under construction </link:label>
<link:label id="lab_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59_label_en-US" xlink:label="lab_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Construction in Progress, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConstructionInProgressGross" xlink:label="loc_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59" xlink:to="lab_us-gaap_ConstructionInProgressGross_67AA8D564A26347E09BD4DD9A9A6CD59" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A_totalLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total property, plant and equipment at cost </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentGross_458450E7F864554E2D1B4DD9A9A6145A" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE_negatedLabel_en-US" xlink:label="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Less: Accumulated depreciation </link:label>
<link:label id="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE_label_en-US" xlink:label="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE" xlink:to="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6CF9A25C2D3351E2E0924DD9A9A675FE" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93_totalLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment, net </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentNet_46D77B070E40EA8561EF4DD9A9A64A93" xlink:type="arc"/>
<link:label id="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF_terseLabel_en-US" xlink:label="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Table] </link:label>
<link:label id="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF_label_en-US" xlink:label="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Table] </link:label>
<link:label id="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF_documentation_en-US" xlink:label="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Table] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AccountingPoliciesTable" xlink:label="loc_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:to="lab_shpgf_AccountingPoliciesTable_F3A12DAC4FE0CFE169E58B712C9DF3AF" xlink:type="arc"/>
<link:label id="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0_terseLabel_en-US" xlink:label="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Line Items] </link:label>
<link:label id="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0_label_en-US" xlink:label="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounting Policies [Line Items] </link:label>
<link:label id="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0_documentation_en-US" xlink:label="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> [Line Items] for Accounting Policies [Table] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AccountingPoliciesLineItems" xlink:label="loc_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:to="lab_shpgf_AccountingPoliciesLineItems_61472DDD621B0A8BD9E98B712C9D6DA0" xlink:type="arc"/>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6_terseLabel_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Basis of Presentation </link:label>
<link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6_label_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Basis of Accounting, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6" xlink:to="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_077F131083FC8E92432F8B712C9D6ED6" xlink:type="arc"/>
<link:label id="lab_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277_terseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Use of Estimates </link:label>
<link:label id="lab_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Use of Estimates, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277" xlink:to="lab_us-gaap_UseOfEstimates_621B9EB9AA40FAE2BDF88B712C9DF277" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation </link:label>
<link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA_label_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA" xlink:to="lab_us-gaap_ConsolidationPolicyTextBlock_2E4C9283A5CBADC2B1008B712C9D47FA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06_terseLabel_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue recognition </link:label>
<link:label id="lab_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06_label_en-US" xlink:label="lab_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Recognition, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06" xlink:to="lab_us-gaap_RevenueRecognitionPolicyTextBlock_2467C2E409529859C2038B712C9D9C06" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business combination and contingent consideration payable </link:label>
<link:label id="lab_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combinations Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B" xlink:to="lab_us-gaap_BusinessCombinationsPolicy_E7DFEEBD7E5E3C96C9F48B712C9DB09B" xlink:type="arc"/>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets </link:label>
<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_10B7F05A1C14398E63488B712C9DDFDC" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value Measurements </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value Measurement, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C" xlink:to="lab_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_79748DDE69A3ED5C4B0A8B712C9D174C" xlink:type="arc"/>
<link:label id="lab_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442_terseLabel_en-US" xlink:label="lab_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts Receivable </link:label>
<link:label id="lab_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442_label_en-US" xlink:label="lab_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Trade and Other Accounts Receivable, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TradeAndOtherAccountsReceivablePolicy" xlink:label="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442" xlink:to="lab_us-gaap_TradeAndOtherAccountsReceivablePolicy_F4AB9AD4DCCE8AB222BD8B712C9DB442" xlink:type="arc"/>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6_label_en-US" xlink:label="lab_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6" xlink:to="lab_us-gaap_InvestmentPolicyTextBlock_AD8123B7418D68A973038B712C9D1DC6" xlink:type="arc"/>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Inventories </link:label>
<link:label id="lab_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21_label_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Inventory, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21" xlink:to="lab_us-gaap_InventoryPolicyTextBlock_CADF40F77AF4F378A8668B712C9DDD21" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_7FEB60A8C260D439FB608B712C9D6033" xlink:type="arc"/>
<link:label id="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553_terseLabel_en-US" xlink:label="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Assets Held for sale </link:label>
<link:label id="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553_label_en-US" xlink:label="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets Held-for-sale [Policy Text Block] </link:label>
<link:label id="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553_documentation_en-US" xlink:label="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Assets Held-for-sale [Policy Text Block] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AssetsHeldforsalePolicyTextBlock" xlink:label="loc_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:to="lab_shpgf_AssetsHeldforsalePolicyTextBlock_564B2FA7673186D1639B8B712C9D1553" xlink:type="arc"/>
<link:label id="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discontinued operations </link:label>
<link:label id="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discontinued Operations, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:label="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4" xlink:to="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_7D3FCBBCDAE5F5D9E43E8B712C9DF7F4" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative financial instruments </link:label>
<link:label id="lab_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F_label_en-US" xlink:label="lab_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F" xlink:to="lab_us-gaap_DerivativesPolicyTextBlock_0B31851AC038BCA4EA4D8B712C9DB48F" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Translation of foreign currency </link:label>
<link:label id="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A_label_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Currency Transactions and Translations Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A" xlink:to="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_8D476283E097B6BE67918B712C9D746A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of product sales </link:label>
<link:label id="lab_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D_label_en-US" xlink:label="lab_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cost of Sales, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CostOfSalesPolicyTextBlock" xlink:label="loc_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D" xlink:to="lab_us-gaap_CostOfSalesPolicyTextBlock_BD998BEAC97C318EE5E68B712C9DB83D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Research and development (R&D) expense </link:label>
<link:label id="lab_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC_label_en-US" xlink:label="lab_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Research, Development, and Computer Software, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock" xlink:label="loc_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC" xlink:to="lab_us-gaap_ResearchDevelopmentAndComputerSoftwarePolicyTextBlock_D9F409A7583EAE2E6E508B712C9DD3BC" xlink:type="arc"/>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B_terseLabel_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Selling, general and administrative expenses </link:label>
<link:label id="lab_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B_label_en-US" xlink:label="lab_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Selling, General and Administrative Expenses, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B" xlink:to="lab_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_4DADEB87AFA0075C4A968B712C9DDA6B" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD_terseLabel_en-US" xlink:label="lab_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Advertising costs </link:label>
<link:label id="lab_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD_label_en-US" xlink:label="lab_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Advertising Costs, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdvertisingCostsPolicyTextBlock" xlink:label="loc_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD" xlink:to="lab_us-gaap_AdvertisingCostsPolicyTextBlock_E80E4500A6017CA042CE8B712C9D92AD" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative arrangements </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement, Accounting Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollaborativeArrangementAccountingPolicy" xlink:label="loc_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664" xlink:to="lab_us-gaap_CollaborativeArrangementAccountingPolicy_CE6F2D1A9593885D8DE38B712C9DF664" xlink:type="arc"/>
<link:label id="lab_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Leased assets </link:label>
<link:label id="lab_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A_label_en-US" xlink:label="lab_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Lessee, Leases [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LesseeLeasesPolicyTextBlock" xlink:label="loc_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A" xlink:to="lab_us-gaap_LesseeLeasesPolicyTextBlock_E2C563436656470F917C8B712C9D578A" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE_terseLabel_en-US" xlink:label="lab_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finance costs of debt </link:label>
<link:label id="lab_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE_label_en-US" xlink:label="lab_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtPolicyTextBlock" xlink:label="loc_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE" xlink:to="lab_us-gaap_DebtPolicyTextBlock_F151FD226452733147958B712C9DC3BE" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes </link:label>
<link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248_label_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248" xlink:to="lab_us-gaap_IncomeTaxPolicyTextBlock_EF49FC82DE009963249F8B712C9D8248" xlink:type="arc"/>
<link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_7A2311F11E82DFE754EA8B712C9D4D19_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock_7A2311F11E82DFE754EA8B712C9D4D19" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Earnings per share </link:label>
<link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_7A2311F11E82DFE754EA8B712C9D4D19_label_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock_7A2311F11E82DFE754EA8B712C9D4D19" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Earnings Per Share, Policy [Policy Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_7A2311F11E82DFE754EA8B712C9D4D19" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_EA2A0AD92D0747066AEB8B712C9D9F26_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_EA2A0AD92D0747066AEB8B712C9D9F26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share-based compensation </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_EA2A0AD92D0747066AEB8B712C9D9F26_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_EA2A0AD92D0747066AEB8B712C9D9F26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] </link:label>
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<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_0B93119FBD16E36AD08B8B712C9D6933_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_0B93119FBD16E36AD08B8B712C9D6933" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements </link:label>
<link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_0B93119FBD16E36AD08B8B712C9D6933_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_0B93119FBD16E36AD08B8B712C9D6933" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> New Accounting Pronouncements, Policy [Policy Text Block] </link:label>
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<link:label id="lab_us-gaap_StockholdersEquityPolicyTextBlock_1351C5F9BF69341189358B712C9D5652_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityPolicyTextBlock_1351C5F9BF69341189358B712C9D5652" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dividend Income, Capital Account, and Distributions </link:label>
<link:label id="lab_us-gaap_StockholdersEquityPolicyTextBlock_1351C5F9BF69341189358B712C9D5652_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityPolicyTextBlock_1351C5F9BF69341189358B712C9D5652" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity, Policy [Policy Text Block] </link:label>
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<link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_8BA78E6258A2FD5913D08B712CCC62A8_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract_8BA78E6258A2FD5913D08B712CCC62A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Financial Position [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_8BA78E6258A2FD5913D08B712CCC62A8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AssetsAbstract_B57F11D0DE25765C48298B712CCC34C0_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract_B57F11D0DE25765C48298B712CCC34C0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ASSETS </link:label>
<link:label id="lab_us-gaap_AssetsAbstract_B57F11D0DE25765C48298B712CCC34C0_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract_B57F11D0DE25765C48298B712CCC34C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_B57F11D0DE25765C48298B712CCC34C0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AssetsCurrentAbstract_1DB29DE5C4BC3345E2F58B712CCC046C_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_1DB29DE5C4BC3345E2F58B712CCC046C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Current assets: </link:label>
<link:label id="lab_us-gaap_AssetsCurrentAbstract_1DB29DE5C4BC3345E2F58B712CCC046C_label_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract_1DB29DE5C4BC3345E2F58B712CCC046C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_1DB29DE5C4BC3345E2F58B712CCC046C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_F1858397BDF684F506468B712CCC0BD4_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_F1858397BDF684F506468B712CCC0BD4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_F1858397BDF684F506468B712CCC0BD4_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_F1858397BDF684F506468B712CCC0BD4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, at Carrying Value </link:label>
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<link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_90DD380F3CC43E65BA8F8B712CCCCC18_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_90DD380F3CC43E65BA8F8B712CCCCC18" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restricted cash </link:label>
<link:label id="lab_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_90DD380F3CC43E65BA8F8B712CCCCC18_label_en-US" xlink:label="lab_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_90DD380F3CC43E65BA8F8B712CCCCC18" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restricted Cash and Cash Equivalents, Current </link:label>
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<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_087B0D005D7D973F06E58B712CCC54D3_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_087B0D005D7D973F06E58B712CCC54D3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable, net </link:label>
<link:label id="lab_us-gaap_AccountsReceivableNetCurrent_087B0D005D7D973F06E58B712CCC54D3_label_en-US" xlink:label="lab_us-gaap_AccountsReceivableNetCurrent_087B0D005D7D973F06E58B712CCC54D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Receivable, Net, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_087B0D005D7D973F06E58B712CCC54D3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AssetsCurrent_C4E2FD60BF09FA7870238B712CCCF67D_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent_C4E2FD60BF09FA7870238B712CCCF67D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total current assets </link:label>
<link:label id="lab_us-gaap_AssetsCurrent_C4E2FD60BF09FA7870238B712CCCF67D_label_en-US" xlink:label="lab_us-gaap_AssetsCurrent_C4E2FD60BF09FA7870238B712CCCF67D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Current </link:label>
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<link:label id="lab_us-gaap_LongTermInvestments_B4B47658A1D3486DC0CB8B712CCC6E23_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermInvestments_B4B47658A1D3486DC0CB8B712CCC6E23" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investments </link:label>
<link:label id="lab_us-gaap_LongTermInvestments_B4B47658A1D3486DC0CB8B712CCC6E23_label_en-US" xlink:label="lab_us-gaap_LongTermInvestments_B4B47658A1D3486DC0CB8B712CCC6E23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Investments </link:label>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_5D7A454C8EEABD8057108B712CCC979F_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet_5D7A454C8EEABD8057108B712CCC979F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, plant and equipment (PP&E), net </link:label>
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<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_322DBCE7BC9D4779EE488B712CCCB3AC_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_322DBCE7BC9D4779EE488B712CCCB3AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible assets, net </link:label>
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<link:label id="lab_us-gaap_StockholdersEquity_E1C8336EC673CC297A678B712CCC9C03_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity_E1C8336EC673CC297A678B712CCC9C03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stockholders' Equity Attributable to Parent </link:label>
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<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_CD13ABE8FBDC47F4B7028B712CCC6603_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_CD13ABE8FBDC47F4B7028B712CCC6603" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities and equity </link:label>
<link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_CD13ABE8FBDC47F4B7028B712CCC6603_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity_CD13ABE8FBDC47F4B7028B712CCC6603" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities and Equity </link:label>
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<link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_614D4EB94B5EE1C6BC7E4DD9A98DC93A_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_614D4EB94B5EE1C6BC7E4DD9A98DC93A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Finite-Lived Intangible Assets [Table] </link:label>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_71AD91CBD994A8DE50274DF7BE43AE33_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_71AD91CBD994A8DE50274DF7BE43AE33" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets by Major Class [Axis] </link:label>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A49672A28D7C4388B2C04DF7EF43FA92_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_A49672A28D7C4388B2C04DF7EF43FA92" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets, Major Class Name [Domain] </link:label>
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<link:label id="lab_us-gaap_ContractualRightsMember_44691EF141EA4D84B1B84DF7EF47FE3D_terseLabel_en-US" xlink:label="lab_us-gaap_ContractualRightsMember_44691EF141EA4D84B1B84DF7EF47FE3D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other contract rights </link:label>
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<link:label id="lab_shpgf_RoyaltyRightsMember_18B25AE89511BF0468C44DF7EF47CB5E_verboseLabel_en-US" xlink:label="lab_shpgf_RoyaltyRightsMember_18B25AE89511BF0468C44DF7EF47CB5E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Royalty rights </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RoyaltyRightsMember" xlink:label="loc_shpgf_RoyaltyRightsMember_18B25AE89511BF0468C44DF7EF47CB5E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_E06C62BD6C1E45678A584DD9A98FFBBD_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_E06C62BD6C1E45678A584DD9A98FFBBD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Finite-Lived Intangible Assets [Line Items] </link:label>
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<link:label id="lab_shpgf_IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod_D073195BBFF4D949B0D74DD9A98F126D_terseLabel_en-US" xlink:label="lab_shpgf_IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod_D073195BBFF4D949B0D74DD9A98F126D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisitions </link:label>
<link:label id="lab_shpgf_IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod_D073195BBFF4D949B0D74DD9A98F126D_label_en-US" xlink:label="lab_shpgf_IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod_D073195BBFF4D949B0D74DD9A98F126D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets Excluding Goodwill, Acquired (Divested) During Period </link:label>
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<link:label id="lab_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_20CA46B7EDEA0FC520104D146328DBC0_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_20CA46B7EDEA0FC520104D146328DBC0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Net </link:label>
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<link:label id="lab_us-gaap_DerivativeInstrumentDetailAbstract_E855D02A15C3345589AC677ECE173E7B_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentDetailAbstract_E855D02A15C3345589AC677ECE173E7B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Instrument Detail [Abstract] </link:label>
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<link:label id="lab_us-gaap_ForeignExchangeContractMember_F3A3B125E444DC69A4AF677ECE183BDB_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignExchangeContractMember_F3A3B125E444DC69A4AF677ECE183BDB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign exchange contracts </link:label>
<link:label id="lab_us-gaap_ForeignExchangeContractMember_F3A3B125E444DC69A4AF677ECE183BDB_label_en-US" xlink:label="lab_us-gaap_ForeignExchangeContractMember_F3A3B125E444DC69A4AF677ECE183BDB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Exchange Contract [Member] </link:label>
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<link:label id="lab_us-gaap_InterestRateContractMember_F44FBC51E83724F1A51D677ECE188CB8_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateContractMember_F44FBC51E83724F1A51D677ECE188CB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Interest rate contracts </link:label>
<link:label id="lab_us-gaap_InterestRateContractMember_F44FBC51E83724F1A51D677ECE188CB8_label_en-US" xlink:label="lab_us-gaap_InterestRateContractMember_F44FBC51E83724F1A51D677ECE188CB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Rate Contract [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_F44FBC51E83724F1A51D677ECE188CB8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BalanceSheetLocationAxis_5AF88E6D6355A1DEB1E0677ECE19B429_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis_5AF88E6D6355A1DEB1E0677ECE19B429" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Axis] </link:label>
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<link:label id="lab_us-gaap_BalanceSheetLocationDomain_034EFEC494BE93C3D41C677ECE19E1AC_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_034EFEC494BE93C3D41C677ECE19E1AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:label id="lab_us-gaap_BalanceSheetLocationDomain_034EFEC494BE93C3D41C677ECE19E1AC_label_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationDomain_034EFEC494BE93C3D41C677ECE19E1AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Balance Sheet Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_034EFEC494BE93C3D41C677ECE19E1AC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_6A93E911D898FEBC6DB6677ECE19F8BA_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_6A93E911D898FEBC6DB6677ECE19F8BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid expenses and other current assets </link:label>
<link:label id="lab_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_6A93E911D898FEBC6DB6677ECE19F8BA_label_en-US" xlink:label="lab_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_6A93E911D898FEBC6DB6677ECE19F8BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Prepaid Expenses and Other Current Assets [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_6A93E911D898FEBC6DB6677ECE19F8BA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherCurrentLiabilitiesMember_B7FABDF3061EB1B7C85D677ED0ED417C_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCurrentLiabilitiesMember_B7FABDF3061EB1B7C85D677ED0ED417C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other current liabilities </link:label>
<link:label id="lab_us-gaap_OtherCurrentLiabilitiesMember_B7FABDF3061EB1B7C85D677ED0ED417C_label_en-US" xlink:label="lab_us-gaap_OtherCurrentLiabilitiesMember_B7FABDF3061EB1B7C85D677ED0ED417C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Current Liabilities [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_B7FABDF3061EB1B7C85D677ED0ED417C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LongTermDebtMember_C952F26C7C9925482E09677ECE190797_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtMember_C952F26C7C9925482E09677ECE190797" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long term borrowings </link:label>
<link:label id="lab_us-gaap_LongTermDebtMember_C952F26C7C9925482E09677ECE190797_label_en-US" xlink:label="lab_us-gaap_LongTermDebtMember_C952F26C7C9925482E09677ECE190797" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Debt [Member] </link:label>
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<link:label id="lab_us-gaap_HedgingDesignationAxis_AE847A66001408042CD0677ECE1944ED_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_AE847A66001408042CD0677ECE1944ED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationAxis_AE847A66001408042CD0677ECE1944ED_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis_AE847A66001408042CD0677ECE1944ED" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_AE847A66001408042CD0677ECE1944ED" xlink:type="locator"/>
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<link:label id="lab_us-gaap_HedgingDesignationDomain_98114B1C8955686C915F677ECE19ABD8_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_98114B1C8955686C915F677ECE19ABD8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:label id="lab_us-gaap_HedgingDesignationDomain_98114B1C8955686C915F677ECE19ABD8_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain_98114B1C8955686C915F677ECE19ABD8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Hedging Designation [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_98114B1C8955686C915F677ECE19ABD8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DesignatedAsHedgingInstrumentMember_9EAA18499F8FE011881A677ECE19B50C_terseLabel_en-US" xlink:label="lab_us-gaap_DesignatedAsHedgingInstrumentMember_9EAA18499F8FE011881A677ECE19B50C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Designated derivative Instruments </link:label>
<link:label id="lab_us-gaap_DesignatedAsHedgingInstrumentMember_9EAA18499F8FE011881A677ECE19B50C_label_en-US" xlink:label="lab_us-gaap_DesignatedAsHedgingInstrumentMember_9EAA18499F8FE011881A677ECE19B50C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Designated as Hedging Instrument [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_9EAA18499F8FE011881A677ECE19B50C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NondesignatedMember_FAB787345E570F833BF8677ECE1A4AE4_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember_FAB787345E570F833BF8677ECE1A4AE4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Undesignated derivative instruments </link:label>
<link:label id="lab_us-gaap_NondesignatedMember_FAB787345E570F833BF8677ECE1A4AE4_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember_FAB787345E570F833BF8677ECE1A4AE4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Not Designated as Hedging Instrument [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_FAB787345E570F833BF8677ECE1A4AE4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativesFairValueLineItems_1A29FAB6EC0F49FAFC14677ECE1A72D4_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_1A29FAB6EC0F49FAFC14677ECE1A72D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativesFairValueLineItems_1A29FAB6EC0F49FAFC14677ECE1A72D4_label_en-US" xlink:label="lab_us-gaap_DerivativesFairValueLineItems_1A29FAB6EC0F49FAFC14677ECE1A72D4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value [Line Items] </link:label>
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<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNetAbstract_283693A8C41025BBBAD6677ECE1AB879_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNetAbstract_283693A8C41025BBBAD6677ECE1AB879" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivatives, Fair Value </link:label>
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<link:label id="lab_us-gaap_DerivativeAssetFairValueNetAbstract_4AB62BEDC76E24B6D048677ECE1ACDDE_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssetFairValueNetAbstract_4AB62BEDC76E24B6D048677ECE1ACDDE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Asset position </link:label>
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<link:label id="lab_us-gaap_DerivativeAssetFairValueGrossLiability_F96B82CDAA8800FA8A38677ECE1A0F95_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssetFairValueGrossLiability_F96B82CDAA8800FA8A38677ECE1A0F95" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Potential effect of rights to offset, asset position </link:label>
<link:label id="lab_us-gaap_DerivativeAssetFairValueGrossLiability_F96B82CDAA8800FA8A38677ECE1A0F95_label_en-US" xlink:label="lab_us-gaap_DerivativeAssetFairValueGrossLiability_F96B82CDAA8800FA8A38677ECE1A0F95" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Asset, Fair Value, Gross Liability </link:label>
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<link:label id="lab_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6_totalLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net derivative, asset position </link:label>
<link:label id="lab_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6_label_en-US" xlink:label="lab_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Asset </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6" xlink:to="lab_us-gaap_DerivativeAssets_7563625F583C4E197E40677ECE1AD1D6" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLiabilityFairValueNetAbstract_EC170EDA2D1DD6BDF8F6677ECE1ACB26_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityFairValueNetAbstract_EC170EDA2D1DD6BDF8F6677ECE1ACB26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability position </link:label>
<link:label id="lab_us-gaap_DerivativeLiabilityFairValueNetAbstract_EC170EDA2D1DD6BDF8F6677ECE1ACB26_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityFairValueNetAbstract_EC170EDA2D1DD6BDF8F6677ECE1ACB26" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Amount Not Offset Against Collateral [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityFairValueNetAbstract" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueNetAbstract_EC170EDA2D1DD6BDF8F6677ECE1ACB26" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability position </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Gross Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeLiability_3EF5683C965CF7FC0A87677ECE1A1852" xlink:type="arc"/>
<link:label id="lab_us-gaap_DerivativeLiabilityFairValueGrossAsset_9456F286D10CA474B12A677ECE1A2219_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityFairValueGrossAsset_9456F286D10CA474B12A677ECE1A2219" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Potential effect of rights to offset, liability position </link:label>
<link:label id="lab_us-gaap_DerivativeLiabilityFairValueGrossAsset_9456F286D10CA474B12A677ECE1A2219_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityFairValueGrossAsset_9456F286D10CA474B12A677ECE1A2219" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative Liability, Fair Value, Gross Asset </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_9456F286D10CA474B12A677ECE1A2219" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeLiabilities_0E05026979FD6F21F84A677ECE1A2813_totalLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilities_0E05026979FD6F21F84A677ECE1A2813" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net derivative, liability position </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_0E05026979FD6F21F84A677ECE1A2813" xlink:type="locator"/>
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<link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_EBB8799119A9DE4020CCE12C46307BC0_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_EBB8799119A9DE4020CCE12C46307BC0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill and Intangible Assets Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_EBB8799119A9DE4020CCE12C46307BC0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_GoodwillDisclosureTextBlock_2DC324D3764809B1F80CE12C4630B6A6_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillDisclosureTextBlock_2DC324D3764809B1F80CE12C4630B6A6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill </link:label>
<link:label id="lab_us-gaap_GoodwillDisclosureTextBlock_2DC324D3764809B1F80CE12C4630B6A6_label_en-US" xlink:label="lab_us-gaap_GoodwillDisclosureTextBlock_2DC324D3764809B1F80CE12C4630B6A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillDisclosureTextBlock" xlink:label="loc_us-gaap_GoodwillDisclosureTextBlock_2DC324D3764809B1F80CE12C4630B6A6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StatementOfStockholdersEquityAbstract_151F74A935A8127771328B712CBD5DD9_label_en-US" xlink:label="lab_us-gaap_StatementOfStockholdersEquityAbstract_151F74A935A8127771328B712CBD5DD9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Stockholders' Equity [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_151F74A935A8127771328B712CBD5DD9" xlink:type="locator"/>
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<link:label id="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE_terseLabel_en-US" xlink:label="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital account </link:label>
<link:label id="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE_label_en-US" xlink:label="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Account [Member] </link:label>
<link:label id="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE_documentation_en-US" xlink:label="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Capital Account [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CapitalAccountMember" xlink:label="loc_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:to="lab_shpgf_CapitalAccountMember_3EAC21F5CDEAA0A2C0F08B712CBDF6CE" xlink:type="arc"/>
<link:label id="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67_terseLabel_en-US" xlink:label="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenue account </link:label>
<link:label id="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67_label_en-US" xlink:label="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Revenue Account [Member] </link:label>
<link:label id="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67_documentation_en-US" xlink:label="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Revenue Account [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RevenueAccountMember" xlink:label="loc_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:to="lab_shpgf_RevenueAccountMember_FC039B857E54718E9DFD8B712CBD8C67" xlink:type="arc"/>
<link:label id="lab_us-gaap_TreasuryStockMember_735C81FFEB9CF83CD9248B712CBDF2CB_terseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockMember_735C81FFEB9CF83CD9248B712CBDF2CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Treasury stock </link:label>
<link:label id="lab_us-gaap_TreasuryStockMember_735C81FFEB9CF83CD9248B712CBDF2CB_label_en-US" xlink:label="lab_us-gaap_TreasuryStockMember_735C81FFEB9CF83CD9248B712CBDF2CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_735C81FFEB9CF83CD9248B712CBDF2CB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_A55CB7B833D89306533A8B712CBD8D2E_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_A55CB7B833D89306533A8B712CBD8D2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated other comprehensive (loss)/income </link:label>
<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_A55CB7B833D89306533A8B712CBD8D2E_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_A55CB7B833D89306533A8B712CBD8D2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> AOCI Attributable to Parent [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_A55CB7B833D89306533A8B712CBD8D2E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_973DDE67AE533DB11AC88B712CBD5701_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_973DDE67AE533DB11AC88B712CBD5701" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Stockholders' Equity [Roll Forward] </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_973DDE67AE533DB11AC88B712CBD5701_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_973DDE67AE533DB11AC88B712CBD5701" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Stockholders' Equity [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_973DDE67AE533DB11AC88B712CBD5701" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockholdersEquity_4A71A7DD0A79F0EE37318B712CBD9EAB_periodStartLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_4A71A7DD0A79F0EE37318B712CBD9EAB" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_4A71A7DD0A79F0EE37318B712CBD9EAB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CommonStockSharesIssued_A8E954BAA6919078C0198B712CBDEEE6_periodStartLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_A8E954BAA6919078C0198B712CBDEEE6" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance (in shares) </link:label>
<link:label id="lab_us-gaap_CommonStockSharesIssued_A8E954BAA6919078C0198B712CBDEEE6_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_A8E954BAA6919078C0198B712CBDEEE6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Shares, Issued </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_A8E954BAA6919078C0198B712CBDEEE6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NetIncomeLoss_93DC515BB8B901AC92288B712CBDD605_netLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss_93DC515BB8B901AC92288B712CBDD605" xlink:role="http://www.xbrl.org/2009/role/netLabel" xlink:type="resource" xml:lang="en-US"> Net income </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_93DC515BB8B901AC92288B712CBDD605" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B47051758D3E2969928B712CBD109C_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B47051758D3E2969928B712CBD109C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other comprehensive income (loss), net of tax </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B47051758D3E2969928B712CBD109C_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_59B47051758D3E2969928B712CBD109C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Net of Tax </link:label>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_CFF5F26FAD08FF46B17F8B712CBD1367_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_CFF5F26FAD08FF46B17F8B712CBD1367" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Options exercised (in shares) </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_CFF5F26FAD08FF46B17F8B712CBD1367_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_CFF5F26FAD08FF46B17F8B712CBD1367" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_CFF5F26FAD08FF46B17F8B712CBD1367" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_296D2FA56BBF58F08B348B712CBD291B_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_296D2FA56BBF58F08B348B712CBD291B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Options exercised </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_296D2FA56BBF58F08B348B712CBD291B_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_296D2FA56BBF58F08B348B712CBD291B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Value, Stock Options Exercised </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_296D2FA56BBF58F08B348B712CBD291B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_3F7AA92ED162164848658B712CBDCF30_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_3F7AA92ED162164848658B712CBDCF30" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued under employee benefit plans and other (in shares) </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_3F7AA92ED162164848658B712CBDCF30_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_3F7AA92ED162164848658B712CBDCF30" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Employee Benefit Plan </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_3F7AA92ED162164848658B712CBDCF30" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_F99EE7EC32F9E9BA5E358B712CBDC786_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_F99EE7EC32F9E9BA5E358B712CBDC786" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued under employee benefit plans and other </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_F99EE7EC32F9E9BA5E358B712CBDC786_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_F99EE7EC32F9E9BA5E358B712CBDC786" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Value, Employee Benefit Plan </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_F99EE7EC32F9E9BA5E358B712CBDC786" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued for the acquisition of Baxalta (in shares) </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Shares, Acquisitions </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8" xlink:to="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_FAC9636F4EADEFCC10418B712CBDE0E8" xlink:type="arc"/>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_6860B05D44C1FB45D1478B712CBDD727_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_6860B05D44C1FB45D1478B712CBDD727" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued for the acquisition of Baxalta </link:label>
<link:label id="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_6860B05D44C1FB45D1478B712CBDD727_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_6860B05D44C1FB45D1478B712CBDD727" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Stock Issued During Period, Value, Acquisitions </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_6860B05D44C1FB45D1478B712CBDD727" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_76A577960FD78CC80E148B712CBD2F09_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_76A577960FD78CC80E148B712CBD2F09" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share-based compensation </link:label>
<link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_76A577960FD78CC80E148B712CBD2F09_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_76A577960FD78CC80E148B712CBD2F09" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_76A577960FD78CC80E148B712CBD2F09" xlink:type="locator"/>
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<link:label id="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6_terseLabel_en-US" xlink:label="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares released by employee benefit trust to satisfy exercise of stock options </link:label>
<link:label id="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6_label_en-US" xlink:label="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Treasury Stock Reissued </link:label>
<link:label id="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6_documentation_en-US" xlink:label="lab_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Equity impact of the value of reissuance of shares (units) held in treasury used to satisfy equity-based compensation obligations exercised by the holders of such rights. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_TreasuryStockReissued" xlink:label="loc_shpgf_TreasuryStockReissued_7F43EEFC10B344886D338B712CBDCAE6" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DividendsCommonStockCash_3B316C4FA7B95DC0FAF18B712CBD7741_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DividendsCommonStockCash_3B316C4FA7B95DC0FAF18B712CBD7741" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Dividends </link:label>
<link:label id="lab_us-gaap_DividendsCommonStockCash_3B316C4FA7B95DC0FAF18B712CBD7741_label_en-US" xlink:label="lab_us-gaap_DividendsCommonStockCash_3B316C4FA7B95DC0FAF18B712CBD7741" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Dividends, Common Stock, Cash </link:label>
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<link:label id="lab_us-gaap_StockholdersEquity_5569A1B767ECA927E0DF8B712CBD15C7_periodEndLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity_5569A1B767ECA927E0DF8B712CBD15C7" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending balance </link:label>
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<link:label id="lab_us-gaap_CommonStockSharesIssued_DEE20DBCDAF880D563088B712CBD27AF_periodEndLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued_DEE20DBCDAF880D563088B712CBD27AF" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Ending balance (in shares) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_DEE20DBCDAF880D563088B712CBD27AF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:label id="lab_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement Location [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302" xlink:to="lab_us-gaap_IncomeStatementLocationDomain_65610C9D199E903B00ED4DD9A9E6B302" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other revenues </link:label>
<link:label id="lab_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619_label_en-US" xlink:label="lab_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Income [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherIncomeMember" xlink:label="loc_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619" xlink:to="lab_us-gaap_OtherIncomeMember_6B8933D70F572CC3FC534DD9A9E60619" xlink:type="arc"/>
<link:label id="lab_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A_terseLabel_en-US" xlink:label="lab_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Product sales </link:label>
<link:label id="lab_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A_label_en-US" xlink:label="lab_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesMember" xlink:label="loc_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A" xlink:to="lab_us-gaap_SalesMember_D94BC27ADE8BDCB52FB54DD9A9E6E18A" xlink:type="arc"/>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D_terseLabel_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement Conditions [Axis] </link:label>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D_label_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement Conditions [Axis] </link:label>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D_documentation_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CollaborativeArrangementConditionsAxis" xlink:label="loc_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:to="lab_shpgf_CollaborativeArrangementConditionsAxis_AAE4E6CDA18D1D8E13304DD9A9E6785D" xlink:type="arc"/>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9_terseLabel_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement Conditions, by Condition [Domain] </link:label>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9_label_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement Conditions, by Condition [Domain] </link:label>
<link:label id="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9_documentation_en-US" xlink:label="lab_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CollaborativeArrangementConditionsByConditionDomain" xlink:label="loc_shpgf_CollaborativeArrangementConditionsByConditionDomain_4AC5495404B2179808694DD9A9E6D2D9" xlink:type="locator"/>
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<link:label id="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA_terseLabel_en-US" xlink:label="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Development Milestone </link:label>
<link:label id="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA_label_en-US" xlink:label="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Development Milestone [Member] </link:label>
<link:label id="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA_documentation_en-US" xlink:label="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_DevelopmentMilestoneMember" xlink:label="loc_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:to="lab_shpgf_DevelopmentMilestoneMember_D4699B8633B0E2A57E444DD9A9E675BA" xlink:type="arc"/>
<link:label id="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C_terseLabel_en-US" xlink:label="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sales Milestone </link:label>
<link:label id="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C_label_en-US" xlink:label="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Sales Milestone [Member] </link:label>
<link:label id="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C_documentation_en-US" xlink:label="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SalesMilestoneMember" xlink:label="loc_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:to="lab_shpgf_SalesMilestoneMember_24D6D546815855B9C7F34DD9A9E6BD6C" xlink:type="arc"/>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:label id="lab_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170_label_en-US" xlink:label="lab_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Arrangement and Non-arrangement Transactions [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170" xlink:to="lab_us-gaap_TypeOfArrangementAxis_6BED56C947B832ED5CFE4DD9A9E68170" xlink:type="arc"/>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_C65928CA0DB762DD5FA44DD9A9E697AB_terseLabel_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_C65928CA0DB762DD5FA44DD9A9E697AB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:label id="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_C65928CA0DB762DD5FA44DD9A9E697AB_label_en-US" xlink:label="lab_us-gaap_ArrangementsAndNonarrangementTransactionsMember_C65928CA0DB762DD5FA44DD9A9E697AB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Arrangements and Non-arrangement Transactions [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_C65928CA0DB762DD5FA44DD9A9E697AB" xlink:type="locator"/>
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<link:label id="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3_terseLabel_en-US" xlink:label="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Out-licensing Arrangement </link:label>
<link:label id="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3_label_en-US" xlink:label="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Out-licensing Arrangement [Member] </link:label>
<link:label id="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3_documentation_en-US" xlink:label="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OutLicensingArrangementMember" xlink:label="loc_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:to="lab_shpgf_OutLicensingArrangementMember_0CE54906785348B92A154DD9A9E737E3" xlink:type="arc"/>
<link:label id="lab_us-gaap_CollaborativeArrangementMember_16B411B45CA64614ECD94DD9A9E74709_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementMember_16B411B45CA64614ECD94DD9A9E74709" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative and in-licensing arrangements </link:label>
<link:label id="lab_us-gaap_CollaborativeArrangementMember_16B411B45CA64614ECD94DD9A9E74709_label_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementMember_16B411B45CA64614ECD94DD9A9E74709" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangement [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_16B411B45CA64614ECD94DD9A9E74709" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_3F3E8C6F76BD4E310FDE4DD9A9E7CBFD_terseLabel_en-US" xlink:label="lab_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_3F3E8C6F76BD4E310FDE4DD9A9E7CBFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] </link:label>
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<link:label id="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88_terseLabel_en-US" xlink:label="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum milestone payment receivable </link:label>
<link:label id="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88_label_en-US" xlink:label="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Receivable From Collaborators Maximum </link:label>
<link:label id="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88_documentation_en-US" xlink:label="lab_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Receivable From Collaborators Maximum </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ReceivableFromCollaboratorsMaximum" xlink:label="loc_shpgf_ReceivableFromCollaboratorsMaximum_E70772FBB9A30FE2312C4DD9A9E7EB88" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ProceedsFromCollaborators_7093DB4CD7BD25B42A104DD9A9E78517_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromCollaborators_7093DB4CD7BD25B42A104DD9A9E78517" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Milestone payments received </link:label>
<link:label id="lab_us-gaap_ProceedsFromCollaborators_7093DB4CD7BD25B42A104DD9A9E78517_label_en-US" xlink:label="lab_us-gaap_ProceedsFromCollaborators_7093DB4CD7BD25B42A104DD9A9E78517" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Collaborators </link:label>
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<link:label id="lab_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTextBlock_B8BF675123C150EFEA00250D9575EF73_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTextBlock_B8BF675123C150EFEA00250D9575EF73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Defined Benefit Plans Disclosures [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_1E985F965C344933517C1F1E7A515904_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_1E985F965C344933517C1F1E7A515904" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-current assets: </link:label>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_1E985F965C344933517C1F1E7A515904_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_1E985F965C344933517C1F1E7A515904" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Assets [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_1E985F965C344933517C1F1E7A515904" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_70DF6CC4079541018EC824280B2E9B10_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_70DF6CC4079541018EC824280B2E9B10" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Risk-free interest rate </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_70DF6CC4079541018EC824280B2E9B10_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_70DF6CC4079541018EC824280B2E9B10" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate </link:label>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5B966E2D3C24A88A26D9242849F0D17A_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5B966E2D3C24A88A26D9242849F0D17A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expected dividend yield </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5B966E2D3C24A88A26D9242849F0D17A_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5B966E2D3C24A88A26D9242849F0D17A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5B966E2D3C24A88A26D9242849F0D17A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_94AD2733E0AD818F53A3242886F7441C_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_94AD2733E0AD818F53A3242886F7441C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expected life </link:label>
<link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_94AD2733E0AD818F53A3242886F7441C_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_94AD2733E0AD818F53A3242886F7441C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_94AD2733E0AD818F53A3242886F7441C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_2CA9B0155BEB22593FE42428CC16691E_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_2CA9B0155BEB22593FE42428CC16691E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Volatility </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_2CA9B0155BEB22593FE42428CC16691E_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_2CA9B0155BEB22593FE42428CC16691E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_2CA9B0155BEB22593FE42428CC16691E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_845E28804C24CA9D0F654DD9A96F0963" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73_periodStartLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Balance at January 1, </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_4728281EF0AEA131951D4DD9A96F9A73" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements_C707A70510E74B6ACA624DD9A96F8FD1_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements_C707A70510E74B6ACA624DD9A96F8FD1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisitions </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements_C707A70510E74B6ACA624DD9A96F8FD1_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements_C707A70510E74B6ACA624DD9A96F8FD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases, (Sales), Issuances, (Settlements) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchasesSalesIssuancesSettlements_C707A70510E74B6ACA624DD9A96F8FD1" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_DBC3C38FAEDCA04BA32B4DD9A96F06A6_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_DBC3C38FAEDCA04BA32B4DD9A96F06A6" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value included in earnings </link:label>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_DBC3C38FAEDCA04BA32B4DD9A96F06A6_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_DBC3C38FAEDCA04BA32B4DD9A96F06A6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings </link:label>
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<link:label id="lab_shpgf_ChangeInFairValueDuringPeriodWithCorrespondingAdjustmentToAssociatedIntangibleAsset_05A2CCF9A3AA645729A34DD9A96F7DD4_label_en-US" xlink:label="lab_shpgf_ChangeInFairValueDuringPeriodWithCorrespondingAdjustmentToAssociatedIntangibleAsset_05A2CCF9A3AA645729A34DD9A96F7DD4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Change in Fair Value during the period with corresponding adjustment to the associated intangible asset </link:label>
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<link:label id="lab_us-gaap_AccountsPayableTradeCurrent_95250468A4A2AD83DF85E12C45494FBF_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableTradeCurrent_95250468A4A2AD83DF85E12C45494FBF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable and accrued purchases </link:label>
<link:label id="lab_us-gaap_AccountsPayableTradeCurrent_95250468A4A2AD83DF85E12C45494FBF_label_en-US" xlink:label="lab_us-gaap_AccountsPayableTradeCurrent_95250468A4A2AD83DF85E12C45494FBF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accounts Payable, Trade, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableTradeCurrent" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_95250468A4A2AD83DF85E12C45494FBF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrued employee compensation and benefits payable </link:label>
<link:label id="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C_label_en-US" xlink:label="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Employee-related Liabilities, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C" xlink:to="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_675A0853E9A5458DDC58E12C4549999C" xlink:type="arc"/>
<link:label id="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842_terseLabel_en-US" xlink:label="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrued rebates </link:label>
<link:label id="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842_label_en-US" xlink:label="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accrued Rebates </link:label>
<link:label id="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842_documentation_en-US" xlink:label="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Accrued Rebates </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AccruedRebates" xlink:label="loc_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:to="lab_shpgf_AccruedRebates_7375EDC39442A863E7DAE12C45499842" xlink:type="arc"/>
<link:label id="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370_terseLabel_en-US" xlink:label="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accrued sales returns </link:label>
<link:label id="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370_label_en-US" xlink:label="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance For Sales Returns </link:label>
<link:label id="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370_documentation_en-US" xlink:label="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Allowance For Sales Returns </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AllowanceForSalesReturns" xlink:label="loc_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:to="lab_shpgf_AllowanceForSalesReturns_1DD7CD7E24584434C229E12C45491370" xlink:type="arc"/>
<link:label id="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1_terseLabel_en-US" xlink:label="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other accrued expenses </link:label>
<link:label id="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1_label_en-US" xlink:label="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Accrued Expenses, Current </link:label>
<link:label id="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1_documentation_en-US" xlink:label="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Other Accrued Expenses, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OtherAccruedExpensesCurrent" xlink:label="loc_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:to="lab_shpgf_OtherAccruedExpensesCurrent_873D7A7E204996D2EDE7E1852AD531B1" xlink:type="arc"/>
<link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_392DBB2074F38E181398E12C45490D0D_totalLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_392DBB2074F38E181398E12C45490D0D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Accounts payable and accrued expenses, total </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_392DBB2074F38E181398E12C45490D0D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_392DBB2074F38E181398E12C45490D0D" xlink:to="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_392DBB2074F38E181398E12C45490D0D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D_terseLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provision for discounts and doubtful accounts </link:label>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D_label_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts Receivable [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_A6ED06A443307B0741174D14633AB34D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206_periodStartLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> As of January 1, </link:label>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206_label_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts Receivable, Current </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_6F2AEAF96F975B0D7C6B4D14633AD206" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7_terseLabel_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provision charged to operations </link:label>
<link:label id="lab_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7_label_en-US" xlink:label="lab_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Provision for Doubtful Accounts </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7" xlink:to="lab_us-gaap_ProvisionForDoubtfulAccounts_5FE7D05B5C09BC5BAD5D4D14633A3AD7" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07_negatedLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Payments/credits </link:label>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07_label_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Allowance for Doubtful Accounts Receivable, Write-offs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07" xlink:to="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_9FB156B3A2E2A63A24BF4D14633ACB07" xlink:type="arc"/>
<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7D6753371ED92B8F811F4D14633B78CE_periodEndLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7D6753371ED92B8F811F4D14633B78CE" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> As of December 31, </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7D6753371ED92B8F811F4D14633B78CE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_809C386C5A93AD6CE03C2557782E5524_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_809C386C5A93AD6CE03C2557782E5524" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Organization, Consolidation and Presentation of Financial Statements [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_809C386C5A93AD6CE03C2557782E5524" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NatureOfOperations_53046F68D9282BE176B02557782EF2BB_terseLabel_en-US" xlink:label="lab_us-gaap_NatureOfOperations_53046F68D9282BE176B02557782EF2BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Description of Operations </link:label>
<link:label id="lab_us-gaap_NatureOfOperations_53046F68D9282BE176B02557782EF2BB_label_en-US" xlink:label="lab_us-gaap_NatureOfOperations_53046F68D9282BE176B02557782EF2BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Nature of Operations [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NatureOfOperations" xlink:label="loc_us-gaap_NatureOfOperations_53046F68D9282BE176B02557782EF2BB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_80D0F6B8651381BD7DAEE1D1F2B8D6D4_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_80D0F6B8651381BD7DAEE1D1F2B8D6D4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_80D0F6B8651381BD7DAEE1D1F2B8D6D4" xlink:type="locator"/>
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<link:label id="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3_terseLabel_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3_label_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration Payable, Current </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3_documentation_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable due within one year or within the normal operating cycle if longer. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ContingentConsiderationPayableCurrent" xlink:label="loc_shpgf_ContingentConsiderationPayableCurrent_9744CF2409C4C5D96B03E1D1F2B8C8D3" xlink:type="locator"/>
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<link:label id="lab_shpgf_ContingentConsiderationPayableNoncurrent_E92E11C2FBE30E459D96E1D1F2B81C91_terseLabel_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableNoncurrent_E92E11C2FBE30E459D96E1D1F2B81C91" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableNoncurrent_E92E11C2FBE30E459D96E1D1F2B81C91_label_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableNoncurrent_E92E11C2FBE30E459D96E1D1F2B81C91" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration Payable, Noncurrent </link:label>
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<link:label id="lab_country_NL_74A4486D668B195C770C4319B871CAD7_terseLabel_en-US" xlink:label="lab_country_NL_74A4486D668B195C770C4319B871CAD7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Netherlands </link:label>
<link:label id="lab_country_NL_74A4486D668B195C770C4319B871CAD7_label_en-US" xlink:label="lab_country_NL_74A4486D668B195C770C4319B871CAD7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> NETHERLANDS </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_NL" xlink:label="loc_country_NL_74A4486D668B195C770C4319B871CAD7" xlink:type="locator"/>
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<link:label id="lab_country_BE_27D9E2473D3109CD8C5E4319B87132A9_terseLabel_en-US" xlink:label="lab_country_BE_27D9E2473D3109CD8C5E4319B87132A9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Belgium </link:label>
<link:label id="lab_country_BE_27D9E2473D3109CD8C5E4319B87132A9_label_en-US" xlink:label="lab_country_BE_27D9E2473D3109CD8C5E4319B87132A9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> BELGIUM </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_BE" xlink:label="loc_country_BE_27D9E2473D3109CD8C5E4319B87132A9" xlink:type="locator"/>
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<link:label id="lab_country_SG_4BB3FAF23EC5118F94794319B87171AA_terseLabel_en-US" xlink:label="lab_country_SG_4BB3FAF23EC5118F94794319B87171AA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Singapore </link:label>
<link:label id="lab_country_SG_4BB3FAF23EC5118F94794319B87171AA_label_en-US" xlink:label="lab_country_SG_4BB3FAF23EC5118F94794319B87171AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SINGAPORE </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_SG" xlink:label="loc_country_SG_4BB3FAF23EC5118F94794319B87171AA" xlink:type="locator"/>
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<link:label id="lab_country_ES_C829EB0E9640BC07AE904319B871C489_terseLabel_en-US" xlink:label="lab_country_ES_C829EB0E9640BC07AE904319B871C489" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Spain </link:label>
<link:label id="lab_country_ES_C829EB0E9640BC07AE904319B871C489_label_en-US" xlink:label="lab_country_ES_C829EB0E9640BC07AE904319B871C489" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SPAIN </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_ES" xlink:label="loc_country_ES_C829EB0E9640BC07AE904319B871C489" xlink:type="locator"/>
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<link:label id="lab_country_SE_5594AB8831F2C5DA56984319B8715B62_terseLabel_en-US" xlink:label="lab_country_SE_5594AB8831F2C5DA56984319B8715B62" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Sweden </link:label>
<link:label id="lab_country_SE_5594AB8831F2C5DA56984319B8715B62_label_en-US" xlink:label="lab_country_SE_5594AB8831F2C5DA56984319B8715B62" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> SWEDEN </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_SE" xlink:label="loc_country_SE_5594AB8831F2C5DA56984319B8715B62" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_SE_5594AB8831F2C5DA56984319B8715B62" xlink:to="lab_country_SE_5594AB8831F2C5DA56984319B8715B62" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncomeTaxContingencyLineItems_09F6C887AD6C2AEBBCD04319B87201F4_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxContingencyLineItems_09F6C887AD6C2AEBBCD04319B87201F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Tax Contingency [Line Items] </link:label>
<link:label id="lab_us-gaap_IncomeTaxContingencyLineItems_09F6C887AD6C2AEBBCD04319B87201F4_label_en-US" xlink:label="lab_us-gaap_IncomeTaxContingencyLineItems_09F6C887AD6C2AEBBCD04319B87201F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Tax Contingency [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxContingencyLineItems" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_09F6C887AD6C2AEBBCD04319B87201F4" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_7B3ABB14E55EF5C763ED4319B87215C0_verboseLabel_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_7B3ABB14E55EF5C763ED4319B87215C0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Statutory tax rate </link:label>
<link:label id="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_7B3ABB14E55EF5C763ED4319B87215C0_label_en-US" xlink:label="lab_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_7B3ABB14E55EF5C763ED4319B87215C0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_7B3ABB14E55EF5C763ED4319B87215C0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_SeniorNotesMember_963AD1416B31DA0B40B62557765AD4BC_terseLabel_en-US" xlink:label="lab_us-gaap_SeniorNotesMember_963AD1416B31DA0B40B62557765AD4BC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior Notes </link:label>
<link:label id="lab_us-gaap_SeniorNotesMember_963AD1416B31DA0B40B62557765AD4BC_label_en-US" xlink:label="lab_us-gaap_SeniorNotesMember_963AD1416B31DA0B40B62557765AD4BC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Senior Notes [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeniorNotesMember" xlink:label="loc_us-gaap_SeniorNotesMember_963AD1416B31DA0B40B62557765AD4BC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentAxis_CFD195552BEE617EA4012557765ADC8B_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_CFD195552BEE617EA4012557765ADC8B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentAxis_CFD195552BEE617EA4012557765ADC8B_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis_CFD195552BEE617EA4012557765ADC8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_CFD195552BEE617EA4012557765ADC8B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentNameDomain_A059E7E762C2710C3AD62557765A1BDD_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_A059E7E762C2710C3AD62557765A1BDD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:label id="lab_us-gaap_DebtInstrumentNameDomain_A059E7E762C2710C3AD62557765A1BDD_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain_A059E7E762C2710C3AD62557765A1BDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_A059E7E762C2710C3AD62557765A1BDD" xlink:type="locator"/>
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<link:label id="lab_shpgf_VariableRateNotesDue2018Member_5FBF9AEC525E55DAFD652557765AFA9A_terseLabel_en-US" xlink:label="lab_shpgf_VariableRateNotesDue2018Member_5FBF9AEC525E55DAFD652557765AFA9A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable-rate notes due 2018 </link:label>
<link:label id="lab_shpgf_VariableRateNotesDue2018Member_5FBF9AEC525E55DAFD652557765AFA9A_label_en-US" xlink:label="lab_shpgf_VariableRateNotesDue2018Member_5FBF9AEC525E55DAFD652557765AFA9A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable-rate notes due 2018 [Member] </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_VariableRateNotesDue2018Member" xlink:label="loc_shpgf_VariableRateNotesDue2018Member_5FBF9AEC525E55DAFD652557765AFA9A" xlink:type="locator"/>
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<link:label id="lab_shpgf_FixedRateNotesDue2018Member_70519620F9FDB29D07262557765B739B_terseLabel_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2018Member_70519620F9FDB29D07262557765B739B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2018 </link:label>
<link:label id="lab_shpgf_FixedRateNotesDue2018Member_70519620F9FDB29D07262557765B739B_label_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2018Member_70519620F9FDB29D07262557765B739B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2018 [Member] </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_FixedRateNotesDue2018Member" xlink:label="loc_shpgf_FixedRateNotesDue2018Member_70519620F9FDB29D07262557765B739B" xlink:type="locator"/>
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<link:label id="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D_terseLabel_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2020 </link:label>
<link:label id="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D_label_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2020 [Member] </link:label>
<link:label id="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D_documentation_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2020Member_0258B52EE009D554E6C62557765BB99D" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
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<link:label id="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8_terseLabel_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2022 </link:label>
<link:label id="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8_label_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2022 [Member] </link:label>
<link:label id="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8_documentation_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_FixedRateNotesDue2022Member" xlink:label="loc_shpgf_FixedRateNotesDue2022Member_A4396C101DDC9B33032C2557765BF8A8" xlink:type="locator"/>
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<link:label id="lab_shpgf_FixedRateNotesDue2025Member_9A28C8A0F403E576D6972557765B6418_terseLabel_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2025Member_9A28C8A0F403E576D6972557765B6418" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2025 </link:label>
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<link:label id="lab_shpgf_FixedRateNotesDue2045Member_66F8DB1EC2BBED3742EF2557765BE4E3_label_en-US" xlink:label="lab_shpgf_FixedRateNotesDue2045Member_66F8DB1EC2BBED3742EF2557765BE4E3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2045 [Member] </link:label>
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<link:label id="lab_us-gaap_VariableRateAxis_5713F216AA139BB320C12557765BDAE9_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateAxis_5713F216AA139BB320C12557765BDAE9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
<link:label id="lab_us-gaap_VariableRateAxis_5713F216AA139BB320C12557765BDAE9_label_en-US" xlink:label="lab_us-gaap_VariableRateAxis_5713F216AA139BB320C12557765BDAE9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Axis] </link:label>
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<link:label id="lab_us-gaap_VariableRateDomain_3E2EA49CF117B797D4632557765B5E99_terseLabel_en-US" xlink:label="lab_us-gaap_VariableRateDomain_3E2EA49CF117B797D4632557765B5E99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:label id="lab_us-gaap_VariableRateDomain_3E2EA49CF117B797D4632557765B5E99_label_en-US" xlink:label="lab_us-gaap_VariableRateDomain_3E2EA49CF117B797D4632557765B5E99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Variable Rate [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_3E2EA49CF117B797D4632557765B5E99" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1A9E1F1CBA7F5477EE4E2557765B3A54_terseLabel_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1A9E1F1CBA7F5477EE4E2557765B3A54" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> LIBOR </link:label>
<link:label id="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1A9E1F1CBA7F5477EE4E2557765B3A54_label_en-US" xlink:label="lab_us-gaap_LondonInterbankOfferedRateLIBORMember_1A9E1F1CBA7F5477EE4E2557765B3A54" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> London Interbank Offered Rate (LIBOR) [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1A9E1F1CBA7F5477EE4E2557765B3A54" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_0C3BEA078B53CB1FC6DA2557765BF58D_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_0C3BEA078B53CB1FC6DA2557765BF58D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Aggregate amount </link:label>
<link:label id="lab_us-gaap_DebtInstrumentFaceAmount_0C3BEA078B53CB1FC6DA2557765BF58D_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_0C3BEA078B53CB1FC6DA2557765BF58D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Face Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_0C3BEA078B53CB1FC6DA2557765BF58D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Coupon rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Interest Rate, Stated Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_9689948AF27AD5517C6A2557765C43F8" xlink:type="arc"/>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_EDF4BDAFF5DE26F49B022557765CC6E7_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_EDF4BDAFF5DE26F49B022557765CC6E7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Effective Interest Rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_EDF4BDAFF5DE26F49B022557765CC6E7_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_EDF4BDAFF5DE26F49B022557765CC6E7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Interest Rate, Effective Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_EDF4BDAFF5DE26F49B022557765CC6E7" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_448451F8DF5E8966D2422557765C7982_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_448451F8DF5E8966D2422557765C7982" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Effective Interest Rate, Variable Rate </link:label>
<link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_448451F8DF5E8966D2422557765C7982_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_448451F8DF5E8966D2422557765C7982" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Basis Spread on Variable Rate </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_448451F8DF5E8966D2422557765C7982" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DebtInstrumentCarryingAmount_059A044E4C42225E50D32557765C30FC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentCarryingAmount_059A044E4C42225E50D32557765C30FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Carrying amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_059A044E4C42225E50D32557765C30FC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_8DE0FB80D9B0D87A71B8E1DCDDF8054B_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_8DE0FB80D9B0D87A71B8E1DCDDF8054B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> ABO </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_8DE0FB80D9B0D87A71B8E1DCDDF8054B_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_8DE0FB80D9B0D87A71B8E1DCDDF8054B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Pension Plan with Accumulated Benefit Obligation in Excess of Plan Assets, Accumulated Benefit Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_8DE0FB80D9B0D87A71B8E1DCDDF8054B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_7153E0766FC92BC76499E1DD1870157C_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_7153E0766FC92BC76499E1DD1870157C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value of plan assets </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_7153E0766FC92BC76499E1DD1870157C_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_7153E0766FC92BC76499E1DD1870157C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Pension Plan with Accumulated Benefit Obligation in Excess of Plan Assets, Fair Value of Plan Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_7153E0766FC92BC76499E1DD1870157C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_4ABC868AF540CA933A0A436294976BB8_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_4ABC868AF540CA933A0A436294976BB8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated benefit obligation </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_4ABC868AF540CA933A0A436294976BB8_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_4ABC868AF540CA933A0A436294976BB8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Accumulated Benefit Obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_4ABC868AF540CA933A0A436294976BB8" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_E4DA1DEF080C4366923E436294972CE3_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_E4DA1DEF080C4366923E436294972CE3" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Loss arising during the year </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_E4DA1DEF080C4366923E436294972CE3_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_E4DA1DEF080C4366923E436294972CE3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Defined Benefit Plan, Gain (Loss) Arising During Period, after Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_E4DA1DEF080C4366923E436294972CE3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_4C8B74B14F2AC84FF92A43629497E411_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_4C8B74B14F2AC84FF92A43629497E411" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Curtailment gains (losses) </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_4C8B74B14F2AC84FF92A43629497E411_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_4C8B74B14F2AC84FF92A43629497E411" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Net Periodic Benefit Cost (Credit), Gain (Loss) Due to Curtailment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_4C8B74B14F2AC84FF92A43629497E411" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_F58A216E3EC7419A033343629497E6F8_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_F58A216E3EC7419A033343629497E6F8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Target allocation for plan assets </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_F58A216E3EC7419A033343629497E6F8_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_F58A216E3EC7419A033343629497E6F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Plan Assets, Target Allocation, Percentage </link:label>
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<link:label id="lab_shpgf_DefinedBenefitPlanPlanAssetsVoluntaryContributionsByEmployer_A3851C6CBD757693C212436294979B66_label_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanPlanAssetsVoluntaryContributionsByEmployer_A3851C6CBD757693C212436294979B66" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Plan Assets, Voluntary Contributions By Employer </link:label>
<link:label id="lab_shpgf_DefinedBenefitPlanPlanAssetsVoluntaryContributionsByEmployer_A3851C6CBD757693C212436294979B66_documentation_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanPlanAssetsVoluntaryContributionsByEmployer_A3851C6CBD757693C212436294979B66" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Plan Assets, Voluntary Contributions By Employer </link:label>
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<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_81B0D6CFB61B7546EC7C43629497E3EC_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_81B0D6CFB61B7546EC7C43629497E3EC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expected net cash outflow next year </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_81B0D6CFB61B7546EC7C43629497E3EC_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_81B0D6CFB61B7546EC7C43629497E3EC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Employer Contributions, Next Fiscal Year </link:label>
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<link:label id="lab_us-gaap_DefinedContributionPlanCostRecognized_6F42395D7954DA584E6D43629497A1BD_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedContributionPlanCostRecognized_6F42395D7954DA584E6D43629497A1BD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expenses recognized for defined contribution plan </link:label>
<link:label id="lab_us-gaap_DefinedContributionPlanCostRecognized_6F42395D7954DA584E6D43629497A1BD_label_en-US" xlink:label="lab_us-gaap_DefinedContributionPlanCostRecognized_6F42395D7954DA584E6D43629497A1BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Contribution Plan, Cost </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_6F42395D7954DA584E6D43629497A1BD" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_7B37EDBF942AD31FB0C74319B8D967B9_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_7B37EDBF942AD31FB0C74319B8D967B9" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Expected return on plan assets </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_7B37EDBF942AD31FB0C74319B8D967B9_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_7B37EDBF942AD31FB0C74319B8D967B9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Return (Loss) on Plan Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_7B37EDBF942AD31FB0C74319B8D967B9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_5468393B418F4DA258034319B8D9C878_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_5468393B418F4DA258034319B8D9C878" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Curtailment and other </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_5468393B418F4DA258034319B8D9C878" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_B11B368441CB15A477EB4319B8D95813_totalLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_B11B368441CB15A477EB4319B8D95813" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net periodic benefit cost </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_B11B368441CB15A477EB4319B8D95813_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_B11B368441CB15A477EB4319B8D95813" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Net Periodic Benefit Cost (Credit) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_B11B368441CB15A477EB4319B8D95813" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsRollForward_6797F0D50EDE48FE3BD04DF72B965169_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsRollForward_6797F0D50EDE48FE3BD04DF72B965169" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible Assets Roll Forward </link:label>
<link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsRollForward_6797F0D50EDE48FE3BD04DF72B965169_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsRollForward_6797F0D50EDE48FE3BD04DF72B965169" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Finite-lived Intangible Assets [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRollForward" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_6797F0D50EDE48FE3BD04DF72B965169" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_9F20854D99B2F331B34D4DF72B99B1E9_periodStartLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_9F20854D99B2F331B34D4DF72B99B1E9" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Beginning balance </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_9F20854D99B2F331B34D4DF72B99B1E9" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_315A21E0DDAF278FE4D24DF72B995B48_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_315A21E0DDAF278FE4D24DF72B995B48" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Amortization charged </link:label>
<link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_315A21E0DDAF278FE4D24DF72B995B48_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets_315A21E0DDAF278FE4D24DF72B995B48" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Intangible Assets </link:label>
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<link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_5DC0BFDBDB12385101F74DF72B9AE200_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_5DC0BFDBDB12385101F74DF72B9AE200" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Impairment charges </link:label>
<link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_5DC0BFDBDB12385101F74DF72B9AE200_label_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_5DC0BFDBDB12385101F74DF72B9AE200" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment of Intangible Assets (Excluding Goodwill) </link:label>
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<link:label id="lab_shpgf_IntangibleAssetsTranslationAdjustments_F4D70F9343F72D7D108D4DF72B9AA59F_terseLabel_en-US" xlink:label="lab_shpgf_IntangibleAssetsTranslationAdjustments_F4D70F9343F72D7D108D4DF72B9AA59F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency translation </link:label>
<link:label id="lab_shpgf_IntangibleAssetsTranslationAdjustments_F4D70F9343F72D7D108D4DF72B9AA59F_label_en-US" xlink:label="lab_shpgf_IntangibleAssetsTranslationAdjustments_F4D70F9343F72D7D108D4DF72B9AA59F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets, Translation Adjustments </link:label>
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<link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_B150EFB3BC419CB06100E12C45B7848E_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock_B150EFB3BC419CB06100E12C45B7848E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Taxation </link:label>
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<link:label id="lab_us-gaap_SegmentDiscontinuedOperationsMember_AACF3D4A7B083CF636D04DD9A9C8E3A0_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentDiscontinuedOperationsMember_AACF3D4A7B083CF636D04DD9A9C8E3A0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discontinued Operations </link:label>
<link:label id="lab_us-gaap_SegmentDiscontinuedOperationsMember_AACF3D4A7B083CF636D04DD9A9C8E3A0_label_en-US" xlink:label="lab_us-gaap_SegmentDiscontinuedOperationsMember_AACF3D4A7B083CF636D04DD9A9C8E3A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discontinued Operations [Member] </link:label>
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<link:label id="lab_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_31F1A21AF72C17BD75304DD9A9C86E47_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_31F1A21AF72C17BD75304DD9A9C86E47" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] </link:label>
<link:label id="lab_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_31F1A21AF72C17BD75304DD9A9C86E47_label_en-US" xlink:label="lab_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_31F1A21AF72C17BD75304DD9A9C86E47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] </link:label>
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<link:label id="lab_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_B41919CACF50339AC5634DD9A9C85705_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_B41919CACF50339AC5634DD9A9C85705" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Tax (benefit) expense of discontinued operations </link:label>
<link:label id="lab_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_B41919CACF50339AC5634DD9A9C85705_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_B41919CACF50339AC5634DD9A9C85705" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discontinued Operation, Tax Effect of Discontinued Operation </link:label>
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<link:label id="lab_us-gaap_LitigationSettlementAmountAwardedToOtherParty_B962AD2C895930CB110A4DD9A9C88504_terseLabel_en-US" xlink:label="lab_us-gaap_LitigationSettlementAmountAwardedToOtherParty_B962AD2C895930CB110A4DD9A9C88504" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Settlement amount </link:label>
<link:label id="lab_us-gaap_LitigationSettlementAmountAwardedToOtherParty_B962AD2C895930CB110A4DD9A9C88504_label_en-US" xlink:label="lab_us-gaap_LitigationSettlementAmountAwardedToOtherParty_B962AD2C895930CB110A4DD9A9C88504" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Litigation Settlement, Amount Awarded to Other Party </link:label>
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<link:label id="lab_us-gaap_IncreaseDecreaseInRestrictedCashForOperatingActivities_7185AB09CECC6FDDB9644DD9A9C83AF4_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInRestrictedCashForOperatingActivities_7185AB09CECC6FDDB9644DD9A9C83AF4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Settlement agreement released from escrow </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInRestrictedCashForOperatingActivities_7185AB09CECC6FDDB9644DD9A9C83AF4_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInRestrictedCashForOperatingActivities_7185AB09CECC6FDDB9644DD9A9C83AF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Restricted Cash for Operating Activities </link:label>
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<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_8E21EAAA2F0324EAAA9D4D14630396CD_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_8E21EAAA2F0324EAAA9D4D14630396CD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill </link:label>
<link:label id="lab_us-gaap_ScheduleOfGoodwillTextBlock_8E21EAAA2F0324EAAA9D4D14630396CD_label_en-US" xlink:label="lab_us-gaap_ScheduleOfGoodwillTextBlock_8E21EAAA2F0324EAAA9D4D14630396CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Goodwill [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureAbstract_E3881B29115B3F2BEB95E12C457EFB24_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureAbstract_E3881B29115B3F2BEB95E12C457EFB24" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Information of Parent Company Only Disclosure [Abstract] </link:label>
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<link:label id="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureTextBlock_B83D1C8DAE8204AE6822E12C457E9CB5_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureTextBlock_B83D1C8DAE8204AE6822E12C457E9CB5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Guarantor Financial Information </link:label>
<link:label id="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureTextBlock_B83D1C8DAE8204AE6822E12C457E9CB5_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialInformationOfParentCompanyOnlyDisclosureTextBlock_B83D1C8DAE8204AE6822E12C457E9CB5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Information of Parent Company Only Disclosure [Text Block] </link:label>
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<link:label id="lab_us-gaap_BusinessAcquisitionsProFormaIncomeLossFromContinuingOperationsBeforeChangesInAccountingAndExtraordinaryItemsNetOfTax_3C9B99DCA523AE936481539584566333_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionsProFormaIncomeLossFromContinuingOperationsBeforeChangesInAccountingAndExtraordinaryItemsNetOfTax_3C9B99DCA523AE936481539584566333" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net income from continuing operations </link:label>
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<link:label id="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsAcquisitionAndIntegrationCosts_D519CB28AE211B424897539584569F0F_verboseLabel_en-US" xlink:label="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsAcquisitionAndIntegrationCosts_D519CB28AE211B424897539584569F0F" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Increase (decrease) to net income to reflect acquisition related costs </link:label>
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<link:label id="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153_terseLabel_en-US" xlink:label="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Increase (decrease) to net income to reflect the fair value adjustment to acquisition date inventory. </link:label>
<link:label id="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153_label_en-US" xlink:label="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Data, Adjustments, Inventory, Fair Value </link:label>
<link:label id="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153_documentation_en-US" xlink:label="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInventoryFairValue_9C3AFB5C29D0B3B387AE53958456C153" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> An adjustment to net income to reflect the acquisition and integration costs incurred in relation to the acquisition. </link:label>
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<link:label id="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInterestIncomeExpense_20DB79589274D642C49C53958456C177_terseLabel_en-US" xlink:label="lab_shpgf_BusinessAcquisitionProFormaDataAdjustmentsInterestIncomeExpense_20DB79589274D642C49C53958456C177" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> (Decrease) to net income to reflect the additional interest expense </link:label>
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<link:label id="lab_us-gaap_CondensedCashFlowStatementTable_422CAFF00AF072D6F0378B71290422DD_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedCashFlowStatementTable_422CAFF00AF072D6F0378B71290422DD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statement [Table] </link:label>
<link:label id="lab_us-gaap_CondensedCashFlowStatementTable_422CAFF00AF072D6F0378B71290422DD_label_en-US" xlink:label="lab_us-gaap_CondensedCashFlowStatementTable_422CAFF00AF072D6F0378B71290422DD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statement [Table] </link:label>
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<link:label id="lab_shpgf_SubsidiaryIssuerSAIIDACMember_626F4E747958F7E1C3CF8B7129043BB9_terseLabel_en-US" xlink:label="lab_shpgf_SubsidiaryIssuerSAIIDACMember_626F4E747958F7E1C3CF8B7129043BB9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> SAIIDAC (SAIIDAC Notes Subsidiary Issuer) </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SubsidiaryIssuerSAIIDACMember" xlink:label="loc_shpgf_SubsidiaryIssuerSAIIDACMember_626F4E747958F7E1C3CF8B7129043BB9" xlink:type="locator"/>
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<link:label id="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347_terseLabel_en-US" xlink:label="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Baxalta Inc. (Baxalta Notes Subsidiary Issuer and SAIIDAC Notes Subsidiary Guarantor) </link:label>
<link:label id="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347_label_en-US" xlink:label="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Subsidiary Issuer - Baxalta Inc [Member] </link:label>
<link:label id="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347_documentation_en-US" xlink:label="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Subsidiary Issuer - Baxalta Inc [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SubsidiaryIssuerBaxaltaIncMember" xlink:label="loc_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:to="lab_shpgf_SubsidiaryIssuerBaxaltaIncMember_C8F23620126A1BD4ACF48B712904F347" xlink:type="arc"/>
<link:label id="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC_terseLabel_en-US" xlink:label="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Non-Issuer Subsidiaries </link:label>
<link:label id="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC_label_en-US" xlink:label="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Non-Issuer Subsidiaries [Member] </link:label>
<link:label id="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC_documentation_en-US" xlink:label="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Non-Issuer Subsidiaries [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NonGuarantorNonIssuerSubsidiariesMember" xlink:label="loc_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:to="lab_shpgf_NonGuarantorNonIssuerSubsidiariesMember_658CE074163963BBF8EC8B71290489FC" xlink:type="arc"/>
<link:label id="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB_terseLabel_en-US" xlink:label="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Subsidiaries of Baxalta Notes </link:label>
<link:label id="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB_label_en-US" xlink:label="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Subsidiaries - Baxalta [Member] </link:label>
<link:label id="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB_documentation_en-US" xlink:label="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Non-Guarantor Subsidiaries - Baxalta [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NonGuarantorSubsidiariesBaxaltaMember" xlink:label="loc_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:to="lab_shpgf_NonGuarantorSubsidiariesBaxaltaMember_C84F8CB46B61B14339028B71290433BB" xlink:type="arc"/>
<link:label id="lab_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234_terseLabel_en-US" xlink:label="lab_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shire plc (Parent Guarantor) </link:label>
<link:label id="lab_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234_label_en-US" xlink:label="lab_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Parent Company [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ParentCompanyMember" xlink:label="loc_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234" xlink:to="lab_us-gaap_ParentCompanyMember_D84B88900A3F3696ED258B7129047234" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6" xlink:to="lab_us-gaap_ConsolidationItemsAxis_8C91079C0E6EE8AC956F8B71290463E6" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:label id="lab_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435_label_en-US" xlink:label="lab_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation Items [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435" xlink:to="lab_us-gaap_ConsolidationItemsDomain_52842FCFDDC913D53DB78B7129041435" xlink:type="arc"/>
<link:label id="lab_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A_terseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Eliminations </link:label>
<link:label id="lab_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A_label_en-US" xlink:label="lab_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Consolidation, Eliminations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationEliminationsMember" xlink:label="loc_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A" xlink:to="lab_us-gaap_ConsolidationEliminationsMember_15D04209DD3FEA24EEF08B712904154A" xlink:type="arc"/>
<link:label id="lab_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statements, Captions [Line Items] </link:label>
<link:label id="lab_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A_label_en-US" xlink:label="lab_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statements, Captions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A" xlink:to="lab_us-gaap_CondensedCashFlowStatementsCaptionsLineItems_1044C4B05ED5E22BF2978B712904F13A" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CASH FLOWS FROM OPERATING ACTIVITIES: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9AAE0899F699EB856D1A8B7129049B03" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Net cash provided by/(used in) operating activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Operating Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_ABE00551F6CC42EB50388B712904F859" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CASH FLOWS FROM INVESTING ACTIVITIES: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_64B5D29945E147EE5C108B7129046222" xlink:type="arc"/>
<link:label id="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC_terseLabel_en-US" xlink:label="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Transactions with subsidiaries </link:label>
<link:label id="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC_label_en-US" xlink:label="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net transactions with subsidiaries </link:label>
<link:label id="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC_documentation_en-US" xlink:label="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NetTransactionsWithSubsidiaries" xlink:label="loc_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:to="lab_shpgf_NetTransactionsWithSubsidiaries_909ABE939D7F14E303668B7129044CDC" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Purchases of businesses, net of cash acquired </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Businesses, Net of Cash Acquired </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_3825E55CD5DE6AF907E28B71290449D5" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Purchases of PP&E </link:label>
<link:label id="lab_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments to Acquire Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89" xlink:to="lab_us-gaap_PaymentsToAcquireInvestments_2B0E0D56E6DAD3C913BE8B712904EC89" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsForProceedsFromShortTermInvestments_29956A14126B1D6DFECD8B712904D2B0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromShortTermInvestments_29956A14126B1D6DFECD8B712904D2B0" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds/(payment) from sale of investments </link:label>
<link:label id="lab_us-gaap_PaymentsForProceedsFromShortTermInvestments_29956A14126B1D6DFECD8B712904D2B0_label_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromShortTermInvestments_29956A14126B1D6DFECD8B712904D2B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for (Proceeds from) Short-term Investments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForProceedsFromShortTermInvestments" xlink:label="loc_us-gaap_PaymentsForProceedsFromShortTermInvestments_29956A14126B1D6DFECD8B712904D2B0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInRestrictedCash_2EF712915A311DA66BD78B7129049809_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInRestrictedCash_2EF712915A311DA66BD78B7129049809" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Movements in restricted cash </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInRestrictedCash_2EF712915A311DA66BD78B7129049809_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInRestrictedCash_2EF712915A311DA66BD78B7129049809" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Restricted Cash </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_2EF712915A311DA66BD78B7129049809" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CCF76996CA373AC62CDA8B712904E4DE_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CCF76996CA373AC62CDA8B712904E4DE" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other, net </link:label>
<link:label id="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CCF76996CA373AC62CDA8B712904E4DE_label_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CCF76996CA373AC62CDA8B712904E4DE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for (Proceeds from) Other Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_CCF76996CA373AC62CDA8B712904E4DE" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash used in investing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Investing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_D37B862AA0779CF3432C8B712904CE5E" xlink:type="arc"/>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> CASH FLOWS FROM FINANCING ACTIVITIES: </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0B4F5DBC831F7B10E14C8B712904CF90" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from revolving line of credit, long term and short term borrowings </link:label>
<link:label id="lab_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161" xlink:to="lab_us-gaap_ProceedsFromLinesOfCredit_07F8D560298B383A2B4C8B7129046161" xlink:type="arc"/>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Repayment of revolving line of credit, long term and short term borrowings </link:label>
<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Repayments of Lines of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5" xlink:to="lab_us-gaap_RepaymentsOfLinesOfCredit_DAEAAD338ECC37162CD08B71290493A5" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from intercompany borrowings </link:label>
<link:label id="lab_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626_label_en-US" xlink:label="lab_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from (Repayments of) Related Party Debt </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626" xlink:to="lab_us-gaap_ProceedsFromRepaymentsOfRelatedPartyDebt_8A79EEF97B409048ACCD8B7129041626" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Payment of dividend </link:label>
<link:label id="lab_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2_label_en-US" xlink:label="lab_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments of Ordinary Dividends, Common Stock </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2" xlink:to="lab_us-gaap_PaymentsOfDividendsCommonStock_C78A0942E3D2A91DE68D8B7129049BC2" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Debt issuance costs </link:label>
<link:label id="lab_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534_label_en-US" xlink:label="lab_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments of Debt Issuance Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534" xlink:to="lab_us-gaap_PaymentsOfDebtIssuanceCosts_9DB720B9259530453C148B7129049534" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3462C189271C11E8D06B8B7129049204_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3462C189271C11E8D06B8B7129049204" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other, net </link:label>
<link:label id="lab_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3462C189271C11E8D06B8B7129049204_label_en-US" xlink:label="lab_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3462C189271C11E8D06B8B7129049204" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from (Payments for) Other Financing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3462C189271C11E8D06B8B7129049204" xlink:type="locator"/>
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<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_8CFA0342E5EDFFE3821C8B712904346D_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_8CFA0342E5EDFFE3821C8B712904346D" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net cash (used in)/provided by financing activities </link:label>
<link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_8CFA0342E5EDFFE3821C8B712904346D_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_8CFA0342E5EDFFE3821C8B712904346D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Net Cash Provided by (Used in) Financing Activities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8CFA0342E5EDFFE3821C8B712904346D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_5E7BC0EB7F648D1D38108B7129041916_terseLabel_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_5E7BC0EB7F648D1D38108B7129041916" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Effect of foreign exchange rate changes on cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_5E7BC0EB7F648D1D38108B7129041916_label_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_5E7BC0EB7F648D1D38108B7129041916" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Effect of Exchange Rate on Cash and Cash Equivalents </link:label>
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<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_FFAB483E86C1388D877B8B71290436F8_totalLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_FFAB483E86C1388D877B8B71290436F8" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Net (decrease)/increase in cash and cash equivalents </link:label>
<link:label id="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_FFAB483E86C1388D877B8B71290436F8_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_FFAB483E86C1388D877B8B71290436F8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Cash and Cash Equivalents, Period Increase (Decrease) </link:label>
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<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_B5F853532A1171BEDED08B7129047098_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_B5F853532A1171BEDED08B7129047098" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at beginning of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_B5F853532A1171BEDED08B7129047098" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_5FC516D70B47984B5CE78B71290463F0_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_5FC516D70B47984B5CE78B71290463F0" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> Cash and cash equivalents at end of period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_5FC516D70B47984B5CE78B71290463F0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_5FC516D70B47984B5CE78B71290463F0" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_5FC516D70B47984B5CE78B71290463F0" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule II - Valuation and Qualifying Accounts </link:label>
<link:label id="lab_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928_label_en-US" xlink:label="lab_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Valuation and Qualifying Accounts Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock" xlink:label="loc_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928" xlink:to="lab_us-gaap_ScheduleOfValuationAndQualifyingAccountsDisclosureTextBlock_1C4F6FC31696776AD90BE12DBB0CE928" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfCondensedFinancialStatementsTable" xlink:label="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81" xlink:to="lab_us-gaap_ScheduleOfCondensedFinancialStatementsTable_0CE0B0F2EEBC498ED7A0787DDBCFDE81" xlink:type="arc"/>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2_terseLabel_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:label id="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2_label_en-US" xlink:label="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Financial Statements, Captions [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CondensedFinancialStatementsCaptionsLineItems" xlink:label="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2" xlink:to="lab_us-gaap_CondensedFinancialStatementsCaptionsLineItems_EF8364DC99A7E1705FF3787DDBCFA1F2" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intercompany receivables </link:label>
<link:label id="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584_label_en-US" xlink:label="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Receivable, Current </link:label>
<link:label id="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584_documentation_en-US" xlink:label="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Receivable, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyReceivableCurrent" xlink:label="loc_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:to="lab_shpgf_IntercompanyReceivableCurrent_B6A62198A3A6945752CE787DDBCF7584" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Short term intercompany loan receivable </link:label>
<link:label id="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69_label_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Receivable, Current </link:label>
<link:label id="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69_documentation_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Receivable, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyLoanReceivableCurrent" xlink:label="loc_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:to="lab_shpgf_IntercompanyLoanReceivableCurrent_AB8C0404314FC3E2F15F787DDBCF5E69" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long term intercompany loan receivable </link:label>
<link:label id="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA_label_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Receivable, Noncurrent </link:label>
<link:label id="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA_documentation_en-US" xlink:label="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Receivable, Noncurrent </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyLoanReceivableNoncurrent" xlink:label="loc_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:to="lab_shpgf_IntercompanyLoanReceivableNoncurrent_7B2A380FC9C5BEE56974787DDBCFD0CA" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intercompany payables </link:label>
<link:label id="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2_label_en-US" xlink:label="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Payables, Current </link:label>
<link:label id="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2_documentation_en-US" xlink:label="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Payables, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyPayablesCurrent" xlink:label="loc_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:to="lab_shpgf_IntercompanyPayablesCurrent_E88EB05E178E1362D9B4787DDBCF8AD2" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Short term intercompany loan payable </link:label>
<link:label id="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410_label_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Payable, Current </link:label>
<link:label id="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410_documentation_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Payable, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyLoanPayableCurrent" xlink:label="loc_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:to="lab_shpgf_IntercompanyLoanPayableCurrent_0463F351F7208097F1C3787DDBCF8410" xlink:type="arc"/>
<link:label id="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B_terseLabel_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long term intercompany loan payable </link:label>
<link:label id="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B_label_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Payable, Noncurrent </link:label>
<link:label id="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B_documentation_en-US" xlink:label="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Intercompany Loan Payable, Noncurrent </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IntercompanyLoanPayableNoncurrent" xlink:label="loc_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:to="lab_shpgf_IntercompanyLoanPayableNoncurrent_1C269FAC8F2891734780787DDBCF110B" xlink:type="arc"/>
<link:label id="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659_terseLabel_en-US" xlink:label="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Austria </link:label>
<link:label id="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659_label_en-US" xlink:label="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Austria [Member] </link:label>
<link:label id="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659_documentation_en-US" xlink:label="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Austria [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AustriaMember" xlink:label="loc_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:to="lab_shpgf_AustriaMember_7C4EE7572F6EBC6B40504E1E6FDA8659" xlink:type="arc"/>
<link:label id="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A_terseLabel_en-US" xlink:label="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Rest of the world </link:label>
<link:label id="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A_label_en-US" xlink:label="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Rest Of World [Member] </link:label>
<link:label id="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A_documentation_en-US" xlink:label="lab_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Rest Of World [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RestOfWorldMember" xlink:label="loc_shpgf_RestOfWorldMember_AF69694536232F96558E4DD9A6F62A4A" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Revenues_28A9BEFAB7EED1E8F2594DD9A6FB5B41_terseLabel_en-US" xlink:label="lab_us-gaap_Revenues_28A9BEFAB7EED1E8F2594DD9A6FB5B41" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_28A9BEFAB7EED1E8F2594DD9A6FB5B41" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Revenues_28A9BEFAB7EED1E8F2594DD9A6FB5B41" xlink:to="lab_us-gaap_Revenues_28A9BEFAB7EED1E8F2594DD9A6FB5B41" xlink:type="arc"/>
<link:label id="lab_us-gaap_NoncurrentAssets_5CC6D3710BAA4DD52AA64DD9A6FBE90C_terseLabel_en-US" xlink:label="lab_us-gaap_NoncurrentAssets_5CC6D3710BAA4DD52AA64DD9A6FBE90C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Long-Lived Assets </link:label>
<link:label id="lab_us-gaap_NoncurrentAssets_5CC6D3710BAA4DD52AA64DD9A6FBE90C_label_en-US" xlink:label="lab_us-gaap_NoncurrentAssets_5CC6D3710BAA4DD52AA64DD9A6FBE90C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-Lived Assets </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NoncurrentAssets" xlink:label="loc_us-gaap_NoncurrentAssets_5CC6D3710BAA4DD52AA64DD9A6FBE90C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IntangibleAssetsDisclosureTextBlock_232FEDBD075D0FDAD5194D14631A0CF5_terseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsDisclosureTextBlock_232FEDBD075D0FDAD5194D14631A0CF5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Intangible Assets </link:label>
<link:label id="lab_us-gaap_IntangibleAssetsDisclosureTextBlock_232FEDBD075D0FDAD5194D14631A0CF5_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsDisclosureTextBlock_232FEDBD075D0FDAD5194D14631A0CF5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Intangible Assets Disclosure [Text Block] </link:label>
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<link:label id="lab_us-gaap_TaxesPayableCurrent_19C47473ACDF382B7F0BE18236A5115D_terseLabel_en-US" xlink:label="lab_us-gaap_TaxesPayableCurrent_19C47473ACDF382B7F0BE18236A5115D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes payable </link:label>
<link:label id="lab_us-gaap_TaxesPayableCurrent_19C47473ACDF382B7F0BE18236A5115D_label_en-US" xlink:label="lab_us-gaap_TaxesPayableCurrent_19C47473ACDF382B7F0BE18236A5115D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Taxes Payable, Current </link:label>
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<link:label id="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7_terseLabel_en-US" xlink:label="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Value added taxes </link:label>
<link:label id="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7_label_en-US" xlink:label="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Valued Added Tax Payable, Current </link:label>
<link:label id="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7_documentation_en-US" xlink:label="lab_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Valued Added Tax Payable, Current </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ValuedAddedTaxPayableCurrent" xlink:label="loc_shpgf_ValuedAddedTaxPayableCurrent_F7232A6C46A60FA063D2E18313CD9FA7" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_C233AF912761FE021AB8E183988CA6AA_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_C233AF912761FE021AB8E183988CA6AA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Other current liabilities </link:label>
<link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_C233AF912761FE021AB8E183988CA6AA_label_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent_C233AF912761FE021AB8E183988CA6AA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Accrued Liabilities, Current </link:label>
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<link:label id="lab_us-gaap_OtherLiabilitiesCurrent_E4D48CE9A1B4EAAFD9FBE18684CAD9DF_totalLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesCurrent_E4D48CE9A1B4EAAFD9FBE18684CAD9DF" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Other current liabilities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_E4D48CE9A1B4EAAFD9FBE18684CAD9DF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_E4D48CE9A1B4EAAFD9FBE18684CAD9DF" xlink:to="lab_us-gaap_OtherLiabilitiesCurrent_E4D48CE9A1B4EAAFD9FBE18684CAD9DF" xlink:type="arc"/>
<link:label id="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_116B40B931DF062798622F643AB8CA8A_terseLabel_en-US" xlink:label="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_736EFD4207335C42AFAE275DAFB1773F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reserve for discounts and doubtful accounts </link:label>
<link:label id="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_116B40B931DF062798622F643AB8CA8A_label_en-US" xlink:label="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_736EFD4207335C42AFAE275DAFB1773F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Provision for Doubtful Accounts [Table Text Block] </link:label>
<link:label id="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_116B40B931DF062798622F643AB8CA8A_documentation_en-US" xlink:label="lab_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_736EFD4207335C42AFAE275DAFB1773F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Schedule itemizing movement in provision for discounts and doubtful accounts receivable. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock" xlink:label="loc_shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock_736EFD4207335C42AFAE275DAFB1773F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeTable_B7605B2D34F0240F6B694DD9A94ACF8F_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeTable_B7605B2D34F0240F6B694DD9A94ACF8F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative [Table] </link:label>
<link:label id="lab_us-gaap_DerivativeTable_B7605B2D34F0240F6B694DD9A94ACF8F_label_en-US" xlink:label="lab_us-gaap_DerivativeTable_B7605B2D34F0240F6B694DD9A94ACF8F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_B7605B2D34F0240F6B694DD9A94ACF8F" xlink:type="locator"/>
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<link:label id="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408_terseLabel_en-US" xlink:label="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Interest expense </link:label>
<link:label id="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408_label_en-US" xlink:label="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Income (Expense) [Member] </link:label>
<link:label id="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408_documentation_en-US" xlink:label="lab_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Interest Income (Expense) [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_InterestIncomeExpenseMember" xlink:label="loc_shpgf_InterestIncomeExpenseMember_EBE1A7AE8F3E6FBCA4BD4DD9A94AF408" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ForeignExchangeContractMember_D6F99D35F29E210A030C4DD9A94B0078_verboseLabel_en-US" xlink:label="lab_us-gaap_ForeignExchangeContractMember_D6F99D35F29E210A030C4DD9A94B0078" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Foreign Exchange Contract </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_D6F99D35F29E210A030C4DD9A94B0078" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative [Line Items] </link:label>
<link:label id="lab_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D_label_en-US" xlink:label="lab_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D" xlink:to="lab_us-gaap_DerivativeLineItems_5F72DDDA667A86E9D1A64DD9A94BE50D" xlink:type="arc"/>
<link:label id="lab_invest_DerivativeNotionalAmount_9065B16BA44AC9B570814DD9A94BA2F3_terseLabel_en-US" xlink:label="lab_invest_DerivativeNotionalAmount_9065B16BA44AC9B570814DD9A94BA2F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Notional amount </link:label>
<link:label id="lab_invest_DerivativeNotionalAmount_9065B16BA44AC9B570814DD9A94BA2F3_label_en-US" xlink:label="lab_invest_DerivativeNotionalAmount_9065B16BA44AC9B570814DD9A94BA2F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Notional Amount </link:label>
<link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_9065B16BA44AC9B570814DD9A94BA2F3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeTermOfContract_745D1C4CFADB181FE64D4DD9A94B5C23_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeTermOfContract_745D1C4CFADB181FE64D4DD9A94B5C23" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum duration (in months) </link:label>
<link:label id="lab_us-gaap_DerivativeTermOfContract_745D1C4CFADB181FE64D4DD9A94B5C23_label_en-US" xlink:label="lab_us-gaap_DerivativeTermOfContract_745D1C4CFADB181FE64D4DD9A94B5C23" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Term of Contract </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeTermOfContract" xlink:label="loc_us-gaap_DerivativeTermOfContract_745D1C4CFADB181FE64D4DD9A94B5C23" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNet_06C9B66DAC929FA488704DD9A94BA10B_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNet_06C9B66DAC929FA488704DD9A94BA10B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fair value - net asset/(liability) </link:label>
<link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeNet_06C9B66DAC929FA488704DD9A94BA10B_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeNet_06C9B66DAC929FA488704DD9A94BA10B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Derivative, Fair Value, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_06C9B66DAC929FA488704DD9A94BA10B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_4881228D4332C97CECCA4DD9A94C10A7_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_4881228D4332C97CECCA4DD9A94C10A7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Losses recognized in OCI </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_4881228D4332C97CECCA4DD9A94C10A7" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_804AFD25C659959447E64DD9A97C3EB5_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_804AFD25C659959447E64DD9A97C3EB5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis </link:label>
<link:label id="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_804AFD25C659959447E64DD9A97C3EB5_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_804AFD25C659959447E64DD9A97C3EB5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_E6195CD8573BA802E01A8C8131C2073E_terseLabel_en-US" xlink:label="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_E6195CD8573BA802E01A8C8131C2073E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reclassification out of Accumulated Other Comprehensive Income [Table] </link:label>
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<link:label id="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_E19D4C33E5C56F2C30E88C8131C2ED1D_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_E19D4C33E5C56F2C30E88C8131C2ED1D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pension and other employee benefit </link:label>
<link:label id="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_E19D4C33E5C56F2C30E88C8131C2ED1D_label_en-US" xlink:label="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_E19D4C33E5C56F2C30E88C8131C2ED1D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Defined Benefit Plans Adjustment Attributable to Parent [Member] </link:label>
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<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_6D00C0A311C879DF7B528C8131C2D25E_verboseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_6D00C0A311C879DF7B528C8131C2D25E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Available-for-sale securities </link:label>
<link:label id="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_6D00C0A311C879DF7B528C8131C2D25E_label_en-US" xlink:label="lab_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_6D00C0A311C879DF7B528C8131C2D25E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Accumulated Net Investment Gain (Loss) Attributable to Parent [Member] </link:label>
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<link:label id="lab_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_3F618AE0D52BDDF237128C8131C20476_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_3F618AE0D52BDDF237128C8131C20476" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging activities </link:label>
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<link:label id="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_EBB1C3BD60B7B4A3B4BE8C8131C2E6CF_terseLabel_en-US" xlink:label="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_EBB1C3BD60B7B4A3B4BE8C8131C2E6CF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reclassification out of Accumulated Other Comprehensive Income [Axis] </link:label>
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<link:label id="lab_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_44A0EF0DA76CFF7D5C434DD9A9A18572_label_en-US" xlink:label="lab_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_44A0EF0DA76CFF7D5C434DD9A9A18572" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Disposal Group, Held-for-sale, Not Discontinued Operations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember" xlink:label="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_44A0EF0DA76CFF7D5C434DD9A9A18572" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_44A0EF0DA76CFF7D5C434DD9A9A18572" xlink:to="lab_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_44A0EF0DA76CFF7D5C434DD9A9A18572" xlink:type="arc"/>
<link:label id="lab_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67_terseLabel_en-US" xlink:label="lab_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Divested </link:label>
<link:label id="lab_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67_label_en-US" xlink:label="lab_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Disposal Group, Disposed of by Sale, Not Discontinued Operations [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67" xlink:to="lab_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_F0EE61A144F93D8A44464DD9A9A19D67" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment [Line Items] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentLineItems_EA289E75E2056DAB40264DD9A9A1B8D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364_terseLabel_en-US" xlink:label="lab_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property and equipment, net </link:label>
<link:label id="lab_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364_label_en-US" xlink:label="lab_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Disposal Group, Including Discontinued Operation, Property, Plant and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364" xlink:to="lab_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipment_4E801426CE38C413FE164DD9A9A15364" xlink:type="arc"/>
<link:label id="lab_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Impairment charges </link:label>
<link:label id="lab_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976_label_en-US" xlink:label="lab_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment of Long-Lived Assets to be Disposed of </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976" xlink:to="lab_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_219977A5DBAE5308F03B4DD9A9A25976" xlink:type="arc"/>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from sale of certain assets </link:label>
<link:label id="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Sale of Property, Plant, and Equipment </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D" xlink:to="lab_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_7002930066314AB0750C4DD9A9A2274D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_5C476750CE79E1EB74DE2F643BF2F709_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_0C3EA0AA8B6A5274BA3A4855A058BC47" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Income Statement </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_5C476750CE79E1EB74DE2F643BF2F709_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_0C3EA0AA8B6A5274BA3A4855A058BC47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Income Statement [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_0C3EA0AA8B6A5274BA3A4855A058BC47" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_0C3EA0AA8B6A5274BA3A4855A058BC47" xlink:to="lab_us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock_0C3EA0AA8B6A5274BA3A4855A058BC47" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_2B85B44616FC56BE3A642F643BF27BC9_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_7B2B1D85C3A1529C92067AED32B67410" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Balance Sheet </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_2B85B44616FC56BE3A642F643BF27BC9_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_7B2B1D85C3A1529C92067AED32B67410" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Balance Sheet [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_7B2B1D85C3A1529C92067AED32B67410" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_7B2B1D85C3A1529C92067AED32B67410" xlink:to="lab_us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock_7B2B1D85C3A1529C92067AED32B67410" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_98E3DAE7A61F092F63A02F643BF27C00_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_2FF2889E06C457F684D2A56F74837235" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statement </link:label>
<link:label id="lab_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_98E3DAE7A61F092F63A02F643BF27C00_label_en-US" xlink:label="lab_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_2FF2889E06C457F684D2A56F74837235" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Condensed Cash Flow Statement [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_2FF2889E06C457F684D2A56F74837235" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_2FF2889E06C457F684D2A56F74837235" xlink:to="lab_us-gaap_ScheduleOfCondensedCashFlowStatementTableTextBlock_2FF2889E06C457F684D2A56F74837235" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1871F0F5AA817C7635781EFDDF29391A" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Type [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_6D0B658846B1D1DC68531EFDDF2ACECD" xlink:type="arc"/>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D_terseLabel_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Buildings and leasehold improvements </link:label>
<link:label id="lab_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D_label_en-US" xlink:label="lab_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Building and Building Improvements [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D" xlink:to="lab_us-gaap_BuildingAndBuildingImprovementsMember_CD335D446C6FCC8584721EFF406E435D" xlink:type="arc"/>
<link:label id="lab_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D_terseLabel_en-US" xlink:label="lab_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Office furniture, fittings and equipment </link:label>
<link:label id="lab_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D_label_en-US" xlink:label="lab_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Office Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OfficeEquipmentMember" xlink:label="loc_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D" xlink:to="lab_us-gaap_OfficeEquipmentMember_CA370A35801E6AE43EC71EFF7672F41D" xlink:type="arc"/>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2_terseLabel_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Machinery, equipment and other </link:label>
<link:label id="lab_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2_label_en-US" xlink:label="lab_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Machinery and Equipment [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2" xlink:to="lab_us-gaap_MachineryAndEquipmentMember_FF04357CA2E3D6E94F0A1EFFA909AFB2" xlink:type="arc"/>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_C8444BF4C5D9841C48541EFE6C1B6449_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_C8444BF4C5D9841C48541EFE6C1B6449" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Useful life </link:label>
<link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_C8444BF4C5D9841C48541EFE6C1B6449_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_C8444BF4C5D9841C48541EFE6C1B6449" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Property, Plant and Equipment, Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_C8444BF4C5D9841C48541EFE6C1B6449" xlink:type="locator"/>
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<link:label id="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_51F65984EDC934932DD12F643B460468_terseLabel_en-US" xlink:label="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Calculation of Numerator and Denominator in Earnings Per Share </link:label>
<link:label id="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_51F65984EDC934932DD12F643B460468_label_en-US" xlink:label="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Calculation of Numerator and Denominator in Earnings Per Share 1 [Table Text Block] </link:label>
<link:label id="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_51F65984EDC934932DD12F643B460468_documentation_en-US" xlink:label="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tabular disclosure of the numerators and the denominators of the basic and diluted per-share (or per-unit) computations for income from continuing operations, including the effect that has been given to preferred dividends. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock" xlink:label="loc_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:to="lab_shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock_BED79468DA3E5B3491537F39DCFB033C" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_0021D957BDA05F9012112F643B46D95C_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_A08EFE3BE624531CAC2ACF734955011F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share </link:label>
<link:label id="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_0021D957BDA05F9012112F643B46D95C_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_A08EFE3BE624531CAC2ACF734955011F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_A08EFE3BE624531CAC2ACF734955011F" xlink:type="locator"/>
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<link:label id="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299_terseLabel_en-US" xlink:label="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Agreements and Transactions with Baxter </link:label>
<link:label id="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299_label_en-US" xlink:label="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Agreements And Transactions [Text Block] </link:label>
<link:label id="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299_documentation_en-US" xlink:label="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AgreementsAndTransactionsTextBlock" xlink:label="loc_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:to="lab_shpgf_AgreementsAndTransactionsTextBlock_5661411392A168C042FCE12C4593A299" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 1 year </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards, Next Twelve Months </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards, Next Twelve Months </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths_F1D485FC64C2A540A86B4DD9A8249DFD" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 1 to 2 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Two </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Two </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo_19565D204B45530BD6134DD9A825FCC2" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 2 to 3 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Three </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Three </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree_8E1FDF93BEB5E265EBC14DD9A82546CC" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 3 to 4 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Four </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Four </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour_31DA2B5125D52104669B4DD9A825DC72" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 4 to 5 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Five </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Five </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive_582695EB1D5B491A3F6F4DD9A8253BFE" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Within 5 to 6 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Six </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards In Year Six </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix_F0CE3C1E94D314B875A64DD9A825955A" xlink:type="arc"/>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357_terseLabel_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> After 6 years </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357_label_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards, After Year Six </link:label>
<link:label id="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357_documentation_en-US" xlink:label="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Expirations Of Tax Benefit Carryforwards, After Year Six </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix" xlink:label="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:to="lab_shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix_09D6DB694883096A2FBE4DD9A825D357" xlink:type="arc"/>
<link:label id="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85_terseLabel_en-US" xlink:label="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Indefinitely </link:label>
<link:label id="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85_label_en-US" xlink:label="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Tax Benefit Carryforwards Having No Expiration </link:label>
<link:label id="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85_documentation_en-US" xlink:label="lab_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Tax Benefit Carryforwards Having No Expiration </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_TaxBenefitCarryforwardsHavingNoExpiration" xlink:label="loc_shpgf_TaxBenefitCarryforwardsHavingNoExpiration_7078BE3E2AE15B5823694DD9A825EC85" xlink:type="locator"/>
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<link:label id="lab_us-gaap_TaxCreditCarryforwardAxis_F56913F68FCE33D17C4F4DD9A823787C_terseLabel_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardAxis_F56913F68FCE33D17C4F4DD9A823787C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Tax Credit Carryforward [Axis] </link:label>
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<link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_74085822AA5155CFBE4A7B6AEDAB54B8_terseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense_74085822AA5155CFBE4A7B6AEDAB54B8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other income/(expense), net </link:label>
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<link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_7CC8ADF3550FA44F59D77B6AEDAC0D26_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit_7CC8ADF3550FA44F59D77B6AEDAC0D26" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_7CC8ADF3550FA44F59D77B6AEDAC0D26" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_891AB83EC0AE3D7E544D7B6AEDAC87FA_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments_891AB83EC0AE3D7E544D7B6AEDAC87FA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Equity in income/(losses) of equity method investees, net of taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_891AB83EC0AE3D7E544D7B6AEDAC87FA" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_5A741F1BF50695FE58BA7B6AEDACDACF_verboseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax_5A741F1BF50695FE58BA7B6AEDACDACF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Comprehensive income/(loss) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_5A741F1BF50695FE58BA7B6AEDACDACF" xlink:type="locator"/>
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<link:label id="lab_shpgf_LegalproceedingsAbstract_B4A65F944B94F7E48FBD2F643AE78CF0_label_en-US" xlink:label="lab_shpgf_LegalproceedingsAbstract_B71CE0DD34795F32A55B532582CCD2B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Legal Proceedings [Abstract] </link:label>
<link:label id="lab_shpgf_LegalproceedingsAbstract_B4A65F944B94F7E48FBD2F643AE78CF0_documentation_en-US" xlink:label="lab_shpgf_LegalproceedingsAbstract_B71CE0DD34795F32A55B532582CCD2B0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Legal Proceedings </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_LegalproceedingsAbstract" xlink:label="loc_shpgf_LegalproceedingsAbstract_B71CE0DD34795F32A55B532582CCD2B0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_LegalproceedingsAbstract_B71CE0DD34795F32A55B532582CCD2B0" xlink:to="lab_shpgf_LegalproceedingsAbstract_B71CE0DD34795F32A55B532582CCD2B0" xlink:type="arc"/>
<link:label id="lab_us-gaap_LossContingencyAccrualAtCarryingValue_A267A4F91C415E21F9452F643AE7E640_terseLabel_en-US" xlink:label="lab_us-gaap_LossContingencyAccrualAtCarryingValue_ADD9CE92E4905B74882D453CFD367A9F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Provisions for litigation loss, insurance claims and other disputes </link:label>
<link:label id="lab_us-gaap_LossContingencyAccrualAtCarryingValue_A267A4F91C415E21F9452F643AE7E640_label_en-US" xlink:label="lab_us-gaap_LossContingencyAccrualAtCarryingValue_ADD9CE92E4905B74882D453CFD367A9F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Loss Contingency Accrual </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_ADD9CE92E4905B74882D453CFD367A9F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Financial Instruments </link:label>
<link:label id="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Financial Instruments Disclosure [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:label="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444" xlink:to="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_0299F600744B154698A34D1462D9E444" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Financial assets: </link:label>
<link:label id="lab_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Fair Value Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680" xlink:to="lab_us-gaap_AssetsFairValueDisclosureAbstract_436D884B79419F0126091F1E79D77680" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Marketable equity securities </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531" xlink:to="lab_us-gaap_AvailableForSaleSecurities_1F5ABA350FD3D4C3013B1F1E79D7C531" xlink:type="arc"/>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Marketable debt securities </link:label>
<link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Available-for-sale Securities, Debt Securities </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_03C598235F7F3E338A561F1E79D74BD4" xlink:type="arc"/>
<link:label id="lab_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative instruments </link:label>
<link:label id="lab_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E_label_en-US" xlink:label="lab_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Currency Contract, Asset, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignCurrencyContractAssetFairValueDisclosure" xlink:label="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E" xlink:to="lab_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_362D8F24EFB05860AB0F1F1E79D7D96E" xlink:type="arc"/>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total assets </link:label>
<link:label id="lab_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Assets, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342" xlink:to="lab_us-gaap_AssetsFairValueDisclosure_1EBB5ED4F9856D63F60B1F1E79D79342" xlink:type="arc"/>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_5693B4E5E032CF9E6C9A1F1E79D7FF2E_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_5693B4E5E032CF9E6C9A1F1E79D7FF2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Financial liabilities: </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_5693B4E5E032CF9E6C9A1F1E79D7FF2E_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureAbstract_5693B4E5E032CF9E6C9A1F1E79D7FF2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Fair Value Disclosure [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_5693B4E5E032CF9E6C9A1F1E79D7FF2E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_F2F066DCBFBD4D81E2D41F1E79D7598E_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_F2F066DCBFBD4D81E2D41F1E79D7598E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Derivative instruments </link:label>
<link:label id="lab_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_F2F066DCBFBD4D81E2D41F1E79D7598E_label_en-US" xlink:label="lab_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_F2F066DCBFBD4D81E2D41F1E79D7598E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Foreign Currency Contracts, Liability, Fair Value Disclosure </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure" xlink:label="loc_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_F2F066DCBFBD4D81E2D41F1E79D7598E" xlink:type="locator"/>
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<link:label id="lab_shpgf_ContingentConsiderationPayableFairValueDisclosure_C1109FB68533A062CAE01F1E79D7C142_terseLabel_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableFairValueDisclosure_C1109FB68533A062CAE01F1E79D7C142" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable </link:label>
<link:label id="lab_shpgf_ContingentConsiderationPayableFairValueDisclosure_C1109FB68533A062CAE01F1E79D7C142_label_en-US" xlink:label="lab_shpgf_ContingentConsiderationPayableFairValueDisclosure_C1109FB68533A062CAE01F1E79D7C142" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contingent Consideration Payable, Fair Value Disclosure </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ContingentConsiderationPayableFairValueDisclosure" xlink:label="loc_shpgf_ContingentConsiderationPayableFairValueDisclosure_C1109FB68533A062CAE01F1E79D7C142" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total liabilities </link:label>
<link:label id="lab_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Liabilities, Fair Value Disclosure, Recurring </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureRecurring" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosureRecurring_3C4E58D14E7F054819BB1F1E79D76C43" xlink:type="arc"/>
<link:label id="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F_terseLabel_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisition Integration Costs [Axis] </link:label>
<link:label id="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F_label_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Acquisition Integration Costs [Axis] </link:label>
<link:label id="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F_documentation_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AcquisitionIntegrationCostsAxis" xlink:label="loc_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:to="lab_shpgf_AcquisitionIntegrationCostsAxis_9251905005DA163EDAA89051BA39FE1F" xlink:type="arc"/>
<link:label id="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104_terseLabel_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Acquisition Integration [Domain] </link:label>
<link:label id="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104_label_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Acquisition Integration [Domain] </link:label>
<link:label id="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104_documentation_en-US" xlink:label="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AcquisitionIntegrationDomain" xlink:label="loc_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:to="lab_shpgf_AcquisitionIntegrationDomain_4DA49DDC385B025F83559051BA392104" xlink:type="arc"/>
<link:label id="lab_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C_verboseLabel_en-US" xlink:label="lab_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Employee severance and acceleration of stock compensation </link:label>
<link:label id="lab_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C_label_en-US" xlink:label="lab_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> One-time Termination Benefits [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OneTimeTerminationBenefitsMember" xlink:label="loc_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C" xlink:to="lab_us-gaap_OneTimeTerminationBenefitsMember_BFE599EA9F39242AA4C19051BA3BC23C" xlink:type="arc"/>
<link:label id="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB_terseLabel_en-US" xlink:label="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Third-party professional fees </link:label>
<link:label id="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB_label_en-US" xlink:label="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Third-party Professional Fees [Member] </link:label>
<link:label id="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB_documentation_en-US" xlink:label="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Third-party Professional Fees [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ThirdpartyProfessionalFeesMember" xlink:label="loc_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:to="lab_shpgf_ThirdpartyProfessionalFeesMember_AA38AD85722546E079A29051BA3B28EB" xlink:type="arc"/>
<link:label id="lab_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C_verboseLabel_en-US" xlink:label="lab_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Facility consolidations </link:label>
<link:label id="lab_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C_label_en-US" xlink:label="lab_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Facility Closing [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FacilityClosingMember" xlink:label="loc_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C" xlink:to="lab_us-gaap_FacilityClosingMember_B5C76E7931E0884B31699051BA3B441C" xlink:type="arc"/>
<link:label id="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA_verboseLabel_en-US" xlink:label="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Asset impairments </link:label>
<link:label id="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA_label_en-US" xlink:label="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Asset Impairments [Member] </link:label>
<link:label id="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA_documentation_en-US" xlink:label="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Asset Impairments [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_AssetImpairmentsMember" xlink:label="loc_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:to="lab_shpgf_AssetImpairmentsMember_702218F7E0F129DA9E559051BA3BA7EA" xlink:type="arc"/>
<link:label id="lab_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE_terseLabel_en-US" xlink:label="lab_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contract terminations </link:label>
<link:label id="lab_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE_label_en-US" xlink:label="lab_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contract Termination [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ContractTerminationMember" xlink:label="loc_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE" xlink:to="lab_us-gaap_ContractTerminationMember_16B5D6772DDC9753596B9051BA3B96FE" xlink:type="arc"/>
<link:label id="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E_terseLabel_en-US" xlink:label="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:label id="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E_label_en-US" xlink:label="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Change in Fair Value of Contingent Consideration [Member] </link:label>
<link:label id="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E_documentation_en-US" xlink:label="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Change in Fair Value of Contingent Consideration [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ChangeinFairValueofContingentConsiderationMember" xlink:label="loc_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:to="lab_shpgf_ChangeinFairValueofContingentConsiderationMember_593B95DEDBC15890C4179051BA3BFC9E" xlink:type="arc"/>
<link:label id="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A_terseLabel_en-US" xlink:label="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> NPS, Pharma, Viropharma, Dyax and Baxalta </link:label>
<link:label id="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A_label_en-US" xlink:label="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> NPS, Pharma, Viropharma, Dyax and Baxalta [Member] </link:label>
<link:label id="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A_documentation_en-US" xlink:label="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> NPS, Pharma, Viropharma, Dyax and Baxalta [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember" xlink:label="loc_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:to="lab_shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember_929C5F7966A124B118FB9051BA3B9C1A" xlink:type="arc"/>
<link:label id="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B_terseLabel_en-US" xlink:label="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lumena Pharmaceuticals Inc And Lotus Tissue Repair Inc </link:label>
<link:label id="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B_label_en-US" xlink:label="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Lumena Pharmaceuticals Inc And Lotus Tissue Repair Inc [Member] </link:label>
<link:label id="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B_documentation_en-US" xlink:label="lab_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Lumena Pharmaceuticals Inc And Lotus Tissue Repair Inc [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember" xlink:label="loc_shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember_7D74106DEF1CFA077B2A9051BA3BD78B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_A9E58E15933153F155349051BA3B4ED2_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_A9E58E15933153F155349051BA3B4ED2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Integration and acquisition costs (credits) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_A9E58E15933153F155349051BA3B4ED2" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_A9E58E15933153F155349051BA3B4ED2" xlink:to="lab_us-gaap_BusinessCombinationAcquisitionRelatedCosts_A9E58E15933153F155349051BA3B4ED2" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_C0F16C48F0DF95CEEF7C9051BA3B9C8D_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationIntegrationRelatedCosts_C0F16C48F0DF95CEEF7C9051BA3B9C8D" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Integration costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationIntegrationRelatedCosts" xlink:label="loc_us-gaap_BusinessCombinationIntegrationRelatedCosts_C0F16C48F0DF95CEEF7C9051BA3B9C8D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_B19C5D2CEB57497AAA939051BA3BF53B_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_B19C5D2CEB57497AAA939051BA3BF53B" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_B19C5D2CEB57497AAA939051BA3BF53B_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_B19C5D2CEB57497AAA939051BA3BF53B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_B19C5D2CEB57497AAA939051BA3BF53B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PaymentsForRestructuring_3632BDEB145C0141C7429051BA3BADDD_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRestructuring_3632BDEB145C0141C7429051BA3BADDD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Payments for restructuring </link:label>
<link:label id="lab_us-gaap_PaymentsForRestructuring_3632BDEB145C0141C7429051BA3BADDD_label_en-US" xlink:label="lab_us-gaap_PaymentsForRestructuring_3632BDEB145C0141C7429051BA3BADDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Payments for Restructuring </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRestructuring" xlink:label="loc_us-gaap_PaymentsForRestructuring_3632BDEB145C0141C7429051BA3BADDD" xlink:type="locator"/>
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<link:label id="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759_terseLabel_en-US" xlink:label="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> KALBITOR </link:label>
<link:label id="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759_label_en-US" xlink:label="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Kalbitor [Member] </link:label>
<link:label id="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759_documentation_en-US" xlink:label="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_KalbitorMember" xlink:label="loc_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:to="lab_shpgf_KalbitorMember_BF35245CA8ABEAA043AF4D1463ABD759" xlink:type="arc"/>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37_terseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Indefinite-lived Intangible Assets [Axis] </link:label>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Indefinite-lived Intangible Assets [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_3E20F3A3C539B41E15D14D1463AB7C37" xlink:type="arc"/>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F_terseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Indefinite-lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Indefinite-lived Intangible Assets, Major Class Name [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9643EEDB2243B1C503A64D1463ACD66F" xlink:type="arc"/>
<link:label id="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99_terseLabel_en-US" xlink:label="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> SHP643 </link:label>
<link:label id="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99_label_en-US" xlink:label="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> shp643 [Member] </link:label>
<link:label id="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99_documentation_en-US" xlink:label="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_Shp643Member" xlink:label="loc_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:to="lab_shpgf_Shp643Member_2068C879F67C933C6F914D1463AC2A99" xlink:type="arc"/>
<link:label id="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF_terseLabel_en-US" xlink:label="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Purchase price paid per share of acquiree, in cash (in USD per share) </link:label>
<link:label id="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF_label_en-US" xlink:label="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition Purchase Price Payment Per Share In Cash </link:label>
<link:label id="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF_documentation_en-US" xlink:label="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Represents the purchase price payment per share in cash. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_Businessacquisitionpurchasepricepaymentpershareincash" xlink:label="loc_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:to="lab_shpgf_Businessacquisitionpurchasepricepaymentpershareincash_5824AF04ADB98A5F5A2D4D1463AC8BFF" xlink:type="arc"/>
<link:label id="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9_terseLabel_en-US" xlink:label="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contingent consideration payable (in usd per share) </link:label>
<link:label id="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9_label_en-US" xlink:label="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Additional Per Share Consideration </link:label>
<link:label id="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9_documentation_en-US" xlink:label="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Represents the additional purchase price payment per share in cash for contingent consideration arrangement recognized in connection with a business combination </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration" xlink:label="loc_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:to="lab_shpgf_BusinessCombinationContingentConsiderationArrangementsAdditionalPerShareConsideration_F063FF868FCB45BE48FA4D1463AC50C9" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_A6E6F9D5D6D7F7EC58B64D1463ACEF26_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_A6E6F9D5D6D7F7EC58B64D1463ACEF26" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Preliminary fair value of identifiable assets acquired and liabilities assumed </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_A6E6F9D5D6D7F7EC58B64D1463ACEF26" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_A6E6F9D5D6D7F7EC58B64D1463ACEF26" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_A6E6F9D5D6D7F7EC58B64D1463ACEF26" xlink:type="arc"/>
<link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_D1189EFBFBF8B5483F744D1463ACC1C1_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross_D1189EFBFBF8B5483F744D1463ACC1C1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cash paid on closing </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_D1189EFBFBF8B5483F744D1463ACC1C1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesGross_D1189EFBFBF8B5483F744D1463ACC1C1" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesGross_D1189EFBFBF8B5483F744D1463ACC1C1" xlink:type="arc"/>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Maximum amount of contingent cash consideration </link:label>
<link:label id="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240" xlink:to="lab_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_7821046DC2084B65DDD34D1463AC2240" xlink:type="arc"/>
<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B_terseLabel_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discount rate used in determining fair value of acquired in process research and development, high rate </link:label>
<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B_label_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discount rate used in determining fair value of acquired in process research and development, high rate </link:label>
<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B_documentation_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> The highest rate of a range of rates used to determine the present value of estimated future cash flows pertaining to in-process research and development acquired in a business combination. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate" xlink:label="loc_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:to="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate_F74E3FBAA0B08E5B197D4D1463ADA19B" xlink:type="arc"/>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182_terseLabel_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average amortization period of acquired amortizable intangible assets </link:label>
<link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182_label_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Acquired Finite-lived Intangible Assets, Weighted Average Useful Life </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182" xlink:to="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_EE9831B3784EEE8687D44D1463ADC182" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2018 </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments Due, Next Twelve Months </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C" xlink:to="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CF007B7A76D39D9C00DB246AE4B3EB0C" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2019 </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments, Due in Two Years </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0" xlink:to="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_72EE16765A1D02EFEDAE246BA56597A0" xlink:type="arc"/>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3A4CB9BC2A784F5EBA54246BA57DF211_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3A4CB9BC2A784F5EBA54246BA57DF211" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2020 </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3A4CB9BC2A784F5EBA54246BA57DF211_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3A4CB9BC2A784F5EBA54246BA57DF211" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments, Due in Three Years </link:label>
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<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_558AAC0E75FF23AA6F3A246BA57F3429_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_558AAC0E75FF23AA6F3A246BA57F3429" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2021 </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_558AAC0E75FF23AA6F3A246BA57F3429_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_558AAC0E75FF23AA6F3A246BA57F3429" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments, Due in Four Years </link:label>
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<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_2751AC8F9F9526682C0E246BA59E6029_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_2751AC8F9F9526682C0E246BA59E6029" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2022 </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_2751AC8F9F9526682C0E246BA59E6029_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_2751AC8F9F9526682C0E246BA59E6029" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments, Due in Five Years </link:label>
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<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ADBDF841563C11CE7608246BA5BFA4DA_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ADBDF841563C11CE7608246BA5BFA4DA" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US"> Total </link:label>
<link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ADBDF841563C11CE7608246BA5BFA4DA_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ADBDF841563C11CE7608246BA5BFA4DA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Future Minimum Payments Due </link:label>
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<link:label id="lab_us-gaap_ScheduleOfStockByClassTable_66AE9DCB94C2F6B958318B712A1E16B0_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable_66AE9DCB94C2F6B958318B712A1E16B0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Stock by Class [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfStockByClassTable_66AE9DCB94C2F6B958318B712A1E16B0_label_en-US" xlink:label="lab_us-gaap_ScheduleOfStockByClassTable_66AE9DCB94C2F6B958318B712A1E16B0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Stock by Class [Table] </link:label>
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<link:label id="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0_terseLabel_en-US" xlink:label="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Statement class of treasury stock [Axis] </link:label>
<link:label id="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0_label_en-US" xlink:label="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement class of treasury stock [Axis] </link:label>
<link:label id="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0_documentation_en-US" xlink:label="lab_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Information by the different classes of treasury stock of the entity. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_StatementClassOfTreasuryStockAxis" xlink:label="loc_shpgf_StatementClassOfTreasuryStockAxis_885C0FD379BF871E578C8B712A1E68D0" xlink:type="locator"/>
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<link:label id="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C_terseLabel_en-US" xlink:label="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class Of Company Treasury Stock [Domain] </link:label>
<link:label id="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C_label_en-US" xlink:label="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Class Of Company Treasury Stock [Domain] </link:label>
<link:label id="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C_documentation_en-US" xlink:label="lab_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Share of stock differentiated by the authority of purchases at AGM. Examples include, but are not limited to, shares purchase under share buy-back program and shares purchased by EBT. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ClassOfCompanyTreasuryStockDomain" xlink:label="loc_shpgf_ClassOfCompanyTreasuryStockDomain_84C8E0B50D484E3A03438B712A1E330C" xlink:type="locator"/>
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<link:label id="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688_terseLabel_en-US" xlink:label="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares Held By EBT </link:label>
<link:label id="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688_label_en-US" xlink:label="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Shares Held By EBT [Member] </link:label>
<link:label id="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688_documentation_en-US" xlink:label="lab_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares Held By EBT [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SharesHeldByEBTMember" xlink:label="loc_shpgf_SharesHeldByEBTMember_96A4AE432AECB7BE9D0B8B712A1E3688" xlink:type="locator"/>
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<link:label id="lab_shpgf_SharesHeldUnderShareBuybackProgramMember_A1FDF98D761CD4670BB98B712A1EE17C_terseLabel_en-US" xlink:label="lab_shpgf_SharesHeldUnderShareBuybackProgramMember_A1FDF98D761CD4670BB98B712A1EE17C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shares Held Under Share Buyback Program </link:label>
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<link:label id="lab_shpgf_SharesHeldUnderShareBuybackProgramMember_A1FDF98D761CD4670BB98B712A1EE17C_documentation_en-US" xlink:label="lab_shpgf_SharesHeldUnderShareBuybackProgramMember_A1FDF98D761CD4670BB98B712A1EE17C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Shares Held Under Share Buyback Program [Member] </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SharesHeldUnderShareBuybackProgramMember" xlink:label="loc_shpgf_SharesHeldUnderShareBuybackProgramMember_A1FDF98D761CD4670BB98B712A1EE17C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ClassOfStockLineItems_9BAC0FF54A9C6E7FF5028B712A1ECAC4_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockLineItems_9BAC0FF54A9C6E7FF5028B712A1ECAC4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Class of Stock [Line Items] </link:label>
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<link:label id="lab_us-gaap_CommonStockSharesAuthorized_565AC1D801B899FEA7D58B712A1E5F6C_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized_565AC1D801B899FEA7D58B712A1E5F6C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Ordinary shares authorized </link:label>
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<link:label id="lab_shpgf_SubscriptionSharesSharesAuthorized_E44B0095F777E335B9B28B712A1E762A_terseLabel_en-US" xlink:label="lab_shpgf_SubscriptionSharesSharesAuthorized_E44B0095F777E335B9B28B712A1E762A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Subscriber ordinary shares authorized </link:label>
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<link:label id="lab_shpgf_DistributableReserves_2D29EDF708D6B5B5EBF68B712A1E5D49_terseLabel_en-US" xlink:label="lab_shpgf_DistributableReserves_2D29EDF708D6B5B5EBF68B712A1E5D49" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Distributable reserves (in USD) </link:label>
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<link:label id="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_FB0D35126261C34027122557748B1ED9_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_FB0D35126261C34027122557748B1ED9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Pension and other employee benefits </link:label>
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<link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_82AA0F886B7EA689FA8125577490652B_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_82AA0F886B7EA689FA8125577490652B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income (Loss) [Line Items] </link:label>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_EA8D4524DB1BE1C694D37236818230C7_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_EA8D4524DB1BE1C694D37236818230C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Weighted average exercise price </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_EA8D4524DB1BE1C694D37236818230C7_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_EA8D4524DB1BE1C694D37236818230C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] </link:label>
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<link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_9EA1D0642D39D3F7CC04723681836CE5_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_9EA1D0642D39D3F7CC04723681836CE5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Outstanding as at end of period Intrinsic Value (in GBP) </link:label>
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<link:label id="lab_us-gaap_RetirementPlanTaxStatusAxis_18F617E88404BC0F82BB250D9533F382_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanTaxStatusAxis_18F617E88404BC0F82BB250D9533F382" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Tax Status [Axis] </link:label>
<link:label id="lab_us-gaap_RetirementPlanTaxStatusAxis_18F617E88404BC0F82BB250D9533F382_label_en-US" xlink:label="lab_us-gaap_RetirementPlanTaxStatusAxis_18F617E88404BC0F82BB250D9533F382" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retirement Plan Tax Status [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetirementPlanTaxStatusAxis" xlink:label="loc_us-gaap_RetirementPlanTaxStatusAxis_18F617E88404BC0F82BB250D9533F382" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RetirementPlanTaxStatusDomain_9441DFBCE0E48F624C6D250D9533E7DB_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanTaxStatusDomain_9441DFBCE0E48F624C6D250D9533E7DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Tax Status [Domain] </link:label>
<link:label id="lab_us-gaap_RetirementPlanTaxStatusDomain_9441DFBCE0E48F624C6D250D9533E7DB_label_en-US" xlink:label="lab_us-gaap_RetirementPlanTaxStatusDomain_9441DFBCE0E48F624C6D250D9533E7DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retirement Plan Tax Status [Domain] </link:label>
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<link:label id="lab_us-gaap_QualifiedPlanMember_82D8B7F78CE0A8B89901250D9533AB69_terseLabel_en-US" xlink:label="lab_us-gaap_QualifiedPlanMember_82D8B7F78CE0A8B89901250D9533AB69" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Qualified plan </link:label>
<link:label id="lab_us-gaap_QualifiedPlanMember_82D8B7F78CE0A8B89901250D9533AB69_label_en-US" xlink:label="lab_us-gaap_QualifiedPlanMember_82D8B7F78CE0A8B89901250D9533AB69" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Qualified Plan [Member] </link:label>
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<link:label id="lab_us-gaap_NonqualifiedPlanMember_1507FAD2BFEB2110050B250D9533BDC8_terseLabel_en-US" xlink:label="lab_us-gaap_NonqualifiedPlanMember_1507FAD2BFEB2110050B250D9533BDC8" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Nonqualified plan </link:label>
<link:label id="lab_us-gaap_NonqualifiedPlanMember_1507FAD2BFEB2110050B250D9533BDC8_label_en-US" xlink:label="lab_us-gaap_NonqualifiedPlanMember_1507FAD2BFEB2110050B250D9533BDC8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Nonqualified Plan [Member] </link:label>
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<link:label id="lab_us-gaap_RetirementPlanFundingStatusAxis_FC95E7B6A079370AF2CC250D9533AE98_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanFundingStatusAxis_FC95E7B6A079370AF2CC250D9533AE98" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Funding Status [Axis] </link:label>
<link:label id="lab_us-gaap_RetirementPlanFundingStatusAxis_FC95E7B6A079370AF2CC250D9533AE98_label_en-US" xlink:label="lab_us-gaap_RetirementPlanFundingStatusAxis_FC95E7B6A079370AF2CC250D9533AE98" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retirement Plan Funding Status [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetirementPlanFundingStatusAxis" xlink:label="loc_us-gaap_RetirementPlanFundingStatusAxis_FC95E7B6A079370AF2CC250D9533AE98" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RetirementPlanFundingStatusDomain_058E8E9CF84866C5E94B250D953388F3_terseLabel_en-US" xlink:label="lab_us-gaap_RetirementPlanFundingStatusDomain_058E8E9CF84866C5E94B250D953388F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Retirement Plan Funding Status [Domain] </link:label>
<link:label id="lab_us-gaap_RetirementPlanFundingStatusDomain_058E8E9CF84866C5E94B250D953388F3_label_en-US" xlink:label="lab_us-gaap_RetirementPlanFundingStatusDomain_058E8E9CF84866C5E94B250D953388F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Retirement Plan Funding Status [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetirementPlanFundingStatusDomain" xlink:label="loc_us-gaap_RetirementPlanFundingStatusDomain_058E8E9CF84866C5E94B250D953388F3" xlink:type="locator"/>
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<link:label id="lab_us-gaap_FundedPlanMember_778BAEE7494A0B812949250D95338E91_terseLabel_en-US" xlink:label="lab_us-gaap_FundedPlanMember_778BAEE7494A0B812949250D95338E91" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Funded plans </link:label>
<link:label id="lab_us-gaap_FundedPlanMember_778BAEE7494A0B812949250D95338E91_label_en-US" xlink:label="lab_us-gaap_FundedPlanMember_778BAEE7494A0B812949250D95338E91" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Funded Plan [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FundedPlanMember" xlink:label="loc_us-gaap_FundedPlanMember_778BAEE7494A0B812949250D95338E91" xlink:type="locator"/>
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<link:label id="lab_us-gaap_UnfundedPlanMember_61130ADD68A3F5DD12C9250D95330DD5_terseLabel_en-US" xlink:label="lab_us-gaap_UnfundedPlanMember_61130ADD68A3F5DD12C9250D95330DD5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unfunded plans </link:label>
<link:label id="lab_us-gaap_UnfundedPlanMember_61130ADD68A3F5DD12C9250D95330DD5_label_en-US" xlink:label="lab_us-gaap_UnfundedPlanMember_61130ADD68A3F5DD12C9250D95330DD5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Unfunded Plan [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UnfundedPlanMember" xlink:label="loc_us-gaap_UnfundedPlanMember_61130ADD68A3F5DD12C9250D95330DD5" xlink:type="locator"/>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_3182847B69410DB489B9250D95337AC9" xlink:type="locator"/>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_F359E6332A95D9C8A322250D95338681" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanFundedPercentage_E8504BB20A9C0FEADD20250D95335E47_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanFundedPercentage_E8504BB20A9C0FEADD20250D95335E47" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Funded status percentage </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanFundedPercentage_E8504BB20A9C0FEADD20250D95335E47_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanFundedPercentage_E8504BB20A9C0FEADD20250D95335E47" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Funded Percentage </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanFundedPercentage" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedPercentage_E8504BB20A9C0FEADD20250D95335E47" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_047FA08257CDF75DECC61FBC244AE81A_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_047FA08257CDF75DECC61FBC244AE81A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Income before Income Tax, Domestic and Foreign </link:label>
<link:label id="lab_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_047FA08257CDF75DECC61FBC244AE81A_label_en-US" xlink:label="lab_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_047FA08257CDF75DECC61FBC244AE81A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_593DD1990F945E36A6A21FBCD6031B42_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_593DD1990F945E36A6A21FBCD6031B42" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Components of Income Tax Expense (Benefit) </link:label>
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<link:label id="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_019ED67630D8F4EBA2151FBD9DD191A3_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_019ED67630D8F4EBA2151FBD9DD191A3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Effective Income Tax Rate Reconciliation </link:label>
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<link:label id="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_30E3984330351775FD3C1FBFE71A0AC2_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_30E3984330351775FD3C1FBFE71A0AC2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits </link:label>
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<link:label id="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_3036B16353973A5EBFA41FC0C17D56DF_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_3036B16353973A5EBFA41FC0C17D56DF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Deferred Tax Assets and Liabilities </link:label>
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<link:label id="lab_us-gaap_SummaryOfTaxCreditCarryforwardsTextBlock_35491C296E10A48869531FC4751E97BD_label_en-US" xlink:label="lab_us-gaap_SummaryOfTaxCreditCarryforwardsTextBlock_35491C296E10A48869531FC4751E97BD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Summary of Tax Credit Carryforwards [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_C7BEFB0C4249E8116DACE0FC51DB2A00_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare_C7BEFB0C4249E8116DACE0FC51DB2A00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Common Stock, Par Value (in GBP per share) </link:label>
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<link:label id="lab_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_7548E98CAD51FC2059E5106D61410F6A_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_7548E98CAD51FC2059E5106D61410F6A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Net Gain (Loss) from Cash Flow Hedges </link:label>
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<link:label id="lab_us-gaap_InterestExpenseMember_9CA7A106ECB6A758950E106D61410B15_verboseLabel_en-US" xlink:label="lab_us-gaap_InterestExpenseMember_9CA7A106ECB6A758950E106D61410B15" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Interest income </link:label>
<link:label id="lab_us-gaap_InterestExpenseMember_9CA7A106ECB6A758950E106D61410B15_label_en-US" xlink:label="lab_us-gaap_InterestExpenseMember_9CA7A106ECB6A758950E106D61410B15" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Expense [Member] </link:label>
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<link:label id="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_73DC8B56F5B2C798E1CB4D44385DA908_label_en-US" xlink:label="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_73DC8B56F5B2C798E1CB4D44385DA908" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Quarterly Financial Information [Table Text Block] </link:label>
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<link:label id="lab_us-gaap_NumberOfReportableSegments_3C545255F093FB01359A2F643BD37C54_terseLabel_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_A2F679E3BA9952739E722DF7AE07F760" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of reportable segments </link:label>
<link:label id="lab_us-gaap_NumberOfReportableSegments_3C545255F093FB01359A2F643BD37C54_label_en-US" xlink:label="lab_us-gaap_NumberOfReportableSegments_A2F679E3BA9952739E722DF7AE07F760" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Number of Reportable Segments </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax_1CBD4204AE811F693F004319BBB5A157_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax_1CBD4204AE811F693F004319BBB5A157" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Pension and other employee benefits, tax expense </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax_1CBD4204AE811F693F004319BBB5A157_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax_1CBD4204AE811F693F004319BBB5A157" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive (Income) Loss, Defined Benefit Plan, after Reclassification Adjustment, Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansTax_1CBD4204AE811F693F004319BBB5A157" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_ADF21EFE3C3DBBED76E14319BBB597E2_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_ADF21EFE3C3DBBED76E14319BBB597E2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Unrealized holding gain on available-for-sale securities, tax (benefit) </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_ADF21EFE3C3DBBED76E14319BBB597E2_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_ADF21EFE3C3DBBED76E14319BBB597E2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_ADF21EFE3C3DBBED76E14319BBB597E2" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax_4C64C2555E9D85CC83754319BBB570A2_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax_4C64C2555E9D85CC83754319BBB570A2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Hedging activities, tax expense (benefit) </link:label>
<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax_4C64C2555E9D85CC83754319BBB570A2_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax_4C64C2555E9D85CC83754319BBB570A2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Comprehensive Income (Loss), Derivatives Qualifying as Hedges, Tax </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesTax_4C64C2555E9D85CC83754319BBB570A2" xlink:type="locator"/>
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<link:label id="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265_terseLabel_en-US" xlink:label="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shire shares per Baxalta share </link:label>
<link:label id="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265_label_en-US" xlink:label="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Shares Offered Per Existing Share Ratio </link:label>
<link:label id="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265_documentation_en-US" xlink:label="lab_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Ratio of the number of shares of the acquiree to be offered per share owned in an existing entity that is part of a business combination. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio" xlink:label="loc_shpgf_BusinessCombinationSharesOfferedPerExistingShareRatio_E83E00B4E6F566D374F84D1463EDB265" xlink:type="locator"/>
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<link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_E6CD33252953173123FA4D1463EDDCF2_verboseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_E6CD33252953173123FA4D1463EDDCF2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Shares issued for acquisition (in shares) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_E6CD33252953173123FA4D1463EDDCF2" xlink:type="locator"/>
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<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161_terseLabel_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Cost of sales adjustment </link:label>
<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161_label_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Cost of Sales </link:label>
<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161_documentation_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Cost of Sales </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales" xlink:label="loc_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCostofSales_9841CA72355E233B648B4D1463ED6161" xlink:type="locator"/>
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<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC_terseLabel_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization adjustment </link:label>
<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC_label_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Fair Value Adjustment, Amortization Expense </link:label>
<link:label id="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC_documentation_en-US" xlink:label="lab_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Business Combination, Provisional Information, Initial Accounting Incomplete, Fair Value Adjustment, Amortization Expense </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense" xlink:label="loc_shpgf_BusinessCombinationProvisionalInformationInitialAccountingIncompleteFairValueAdjustmentAmortizationExpense_6C57B9CC47283DF6A2094D1463ED4FBC" xlink:type="locator"/>
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<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871_terseLabel_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Discount rate used in determining fair value of acquired in process research and development, low rate </link:label>
<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871_label_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Discount Rate Used in Determining Fair Value of Acquired in Process Research and Development, Low Rate </link:label>
<link:label id="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871_documentation_en-US" xlink:label="lab_shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate_E5D727E612CB7965D2654D1463EEB871" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> The lowest rate of a range of rates used to determine the present value of estimated future cash flows pertaining to in-process research and development acquired in a business combination. </link:label>
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<link:label id="lab_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_B56B2B5FF2C35ECE36564D1463EE3ED1_terseLabel_en-US" xlink:label="lab_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_B56B2B5FF2C35ECE36564D1463EE3ED1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Defined benefit net liability </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_B56B2B5FF2C35ECE36564D1463EE3ED1" xlink:type="locator"/>
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<link:label id="lab_us-gaap_LegalMattersAndContingenciesTextBlock_3DADF4446E387649FC3AE12C45987EEB_terseLabel_en-US" xlink:label="lab_us-gaap_LegalMattersAndContingenciesTextBlock_3DADF4446E387649FC3AE12C45987EEB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Legal and Other Proceedings </link:label>
<link:label id="lab_us-gaap_LegalMattersAndContingenciesTextBlock_3DADF4446E387649FC3AE12C45987EEB_label_en-US" xlink:label="lab_us-gaap_LegalMattersAndContingenciesTextBlock_3DADF4446E387649FC3AE12C45987EEB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Legal Matters and Contingencies [Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LegalMattersAndContingenciesTextBlock" xlink:label="loc_us-gaap_LegalMattersAndContingenciesTextBlock_3DADF4446E387649FC3AE12C45987EEB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Revenues_D2D7386866501E2CD7584DD9A5FA7265_verboseLabel_en-US" xlink:label="lab_us-gaap_Revenues_D2D7386866501E2CD7584DD9A5FA7265" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Total revenues </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_D2D7386866501E2CD7584DD9A5FA7265" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CostOfGoodsSold_7460F7CAC403AF7E6CEC4DD9A5FA1DEF_verboseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsSold_7460F7CAC403AF7E6CEC4DD9A5FA1DEF" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Cost of product sales </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_7460F7CAC403AF7E6CEC4DD9A5FA1DEF" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_0B7568BF07ADFC6F68914DD9A5FA0464_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_0B7568BF07ADFC6F68914DD9A5FA0464" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Income from continuing operations, net of taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_0B7568BF07ADFC6F68914DD9A5FA0464" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_0B7568BF07ADFC6F68914DD9A5FA0464" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_0B7568BF07ADFC6F68914DD9A5FA0464" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Restructuring and Related Costs [Table] </link:label>
<link:label id="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Restructuring and Related Costs [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B" xlink:to="lab_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_8A8DE7025B64D6BCB4064D14635CFE6B" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1_terseLabel_en-US" xlink:label="lab_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restructuring Type [Axis] </link:label>
<link:label id="lab_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1_label_en-US" xlink:label="lab_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring Type [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1" xlink:to="lab_us-gaap_RestructuringCostAndReserveAxis_0E225514FF2DE9D4052B4D14635C0FD1" xlink:type="arc"/>
<link:label id="lab_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Type of Restructuring [Domain] </link:label>
<link:label id="lab_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594_label_en-US" xlink:label="lab_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Type of Restructuring [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594" xlink:to="lab_us-gaap_TypeOfRestructuringDomain_36793500D949F49707E24D14635C4594" xlink:type="arc"/>
<link:label id="lab_us-gaap_FacilityClosingMember_40506438065196A39B874D14635CB49C_terseLabel_en-US" xlink:label="lab_us-gaap_FacilityClosingMember_40506438065196A39B874D14635CB49C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Closure of manufacturing facilities and asset impairments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FacilityClosingMember" xlink:label="loc_us-gaap_FacilityClosingMember_40506438065196A39B874D14635CB49C" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FacilityClosingMember_40506438065196A39B874D14635CB49C" xlink:to="lab_us-gaap_FacilityClosingMember_40506438065196A39B874D14635CB49C" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7_verboseLabel_en-US" xlink:label="lab_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Employee termination and other costs </link:label>
<link:label id="lab_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7_label_en-US" xlink:label="lab_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Employee Severance [Member] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeSeveranceMember" xlink:label="loc_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7" xlink:to="lab_us-gaap_EmployeeSeveranceMember_C07F697D27DE0A8EBDAF4D14635C7AF7" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22_terseLabel_en-US" xlink:label="lab_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restructuring Cost and Reserve [Line Items] </link:label>
<link:label id="lab_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22_label_en-US" xlink:label="lab_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring Cost and Reserve [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22" xlink:to="lab_us-gaap_RestructuringCostAndReserveLineItems_6B13AEC41D94D9AE64E94D14635C1E22" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Accounts Payable and Accrued Expenses </link:label>
<link:label id="lab_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538" xlink:to="lab_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_8A14BBFA6F9BCD208E51E103A60BD538" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Prepaid Expense and Other Assets, Current </link:label>
<link:label id="lab_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570_label_en-US" xlink:label="lab_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570" xlink:to="lab_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_6BA2082E75C792A8E7C1E0FF3C321570" xlink:type="arc"/>
<link:label id="lab_us-gaap_EmployeeSeveranceMember_035616C97F3B1DAB91914D14634C7928_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeSeveranceMember_035616C97F3B1DAB91914D14634C7928" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Severance and employee benefits </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeSeveranceMember" xlink:label="loc_us-gaap_EmployeeSeveranceMember_035616C97F3B1DAB91914D14634C7928" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeSeveranceMember_035616C97F3B1DAB91914D14634C7928" xlink:to="lab_us-gaap_EmployeeSeveranceMember_035616C97F3B1DAB91914D14634C7928" xlink:type="arc"/>
<link:label id="lab_us-gaap_ContractTerminationMember_51FB9068FAD955AD92A54D14634D6DEA_verboseLabel_en-US" xlink:label="lab_us-gaap_ContractTerminationMember_51FB9068FAD955AD92A54D14634D6DEA" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Lease terminations </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ContractTerminationMember" xlink:label="loc_us-gaap_ContractTerminationMember_51FB9068FAD955AD92A54D14634D6DEA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ContractTerminationMember_51FB9068FAD955AD92A54D14634D6DEA" xlink:to="lab_us-gaap_ContractTerminationMember_51FB9068FAD955AD92A54D14634D6DEA" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B_terseLabel_en-US" xlink:label="lab_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Restructuring Reserve [Roll Forward] </link:label>
<link:label id="lab_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B_label_en-US" xlink:label="lab_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring Reserve [Roll Forward] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringReserveRollForward" xlink:label="loc_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B" xlink:to="lab_us-gaap_RestructuringReserveRollForward_EC81D82F8D01ABDF1ADC4D14634D534B" xlink:type="arc"/>
<link:label id="lab_us-gaap_RestructuringReserve_A5ECCEEC462B808D27AD4D14634DA976_periodStartLabel_en-US" xlink:label="lab_us-gaap_RestructuringReserve_A5ECCEEC462B808D27AD4D14634DA976" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US"> As of January 1, </link:label>
<link:label id="lab_us-gaap_RestructuringReserve_A5ECCEEC462B808D27AD4D14634DA976_label_en-US" xlink:label="lab_us-gaap_RestructuringReserve_A5ECCEEC462B808D27AD4D14634DA976" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring Reserve </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringReserve" xlink:label="loc_us-gaap_RestructuringReserve_A5ECCEEC462B808D27AD4D14634DA976" xlink:type="locator"/>
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<link:label id="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414_terseLabel_en-US" xlink:label="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amount charged to integration costs </link:label>
<link:label id="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414_label_en-US" xlink:label="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Restructuring and Integration Costs </link:label>
<link:label id="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414_documentation_en-US" xlink:label="lab_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Restructuring and Integration Costs </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RestructuringandIntegrationCosts" xlink:label="loc_shpgf_RestructuringandIntegrationCosts_B85898665DC6B4D9A8934D14634D8414" xlink:type="locator"/>
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<link:label id="lab_us-gaap_PaymentsForRestructuring_3FC45B05162996DC94B74D14634DF76F_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRestructuring_3FC45B05162996DC94B74D14634DF76F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Paid/utilized </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRestructuring" xlink:label="loc_us-gaap_PaymentsForRestructuring_3FC45B05162996DC94B74D14634DF76F" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RestructuringReserve_99272A006993A0CAEBB94D14634D7F25_periodEndLabel_en-US" xlink:label="lab_us-gaap_RestructuringReserve_99272A006993A0CAEBB94D14634D7F25" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> As of December 31, </link:label>
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<link:label id="lab_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824" xlink:to="lab_us-gaap_LineOfCreditFacilityTable_2A4683084E5CD20DC9CE7B6AB4530824" xlink:type="arc"/>
<link:label id="lab_us-gaap_SubsidiariesMember_204C2E1B119DA72BA2B17B6AB454E028_terseLabel_en-US" xlink:label="lab_us-gaap_SubsidiariesMember_204C2E1B119DA72BA2B17B6AB454E028" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Shire Acquisitions Investment Ireland Designated Activity Company </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsidiariesMember" xlink:label="loc_us-gaap_SubsidiariesMember_204C2E1B119DA72BA2B17B6AB454E028" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsidiariesMember_204C2E1B119DA72BA2B17B6AB454E028" xlink:to="lab_us-gaap_SubsidiariesMember_204C2E1B119DA72BA2B17B6AB454E028" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:label id="lab_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404_label_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404" xlink:to="lab_us-gaap_CreditFacilityAxis_D0F86174142C85454EC67B6AB455F404" xlink:type="arc"/>
<link:label id="lab_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:label id="lab_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78_label_en-US" xlink:label="lab_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Credit Facility [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78" xlink:to="lab_us-gaap_CreditFacilityDomain_248DC66144EA2BF356417B6AB455AF78" xlink:type="arc"/>
<link:label id="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F_terseLabel_en-US" xlink:label="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Loan Facility [Axis] </link:label>
<link:label id="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F_label_en-US" xlink:label="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Loan Facility [Axis] </link:label>
<link:label id="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F_documentation_en-US" xlink:label="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_LoanFacilityAxis" xlink:label="loc_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:to="lab_shpgf_LoanFacilityAxis_605EFF76BA04B54060F57B6AB456891F" xlink:type="arc"/>
<link:label id="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00_terseLabel_en-US" xlink:label="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Term Loan [Domain] </link:label>
<link:label id="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00_label_en-US" xlink:label="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Term Loan [Domain] </link:label>
<link:label id="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00_documentation_en-US" xlink:label="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_TermLoanDomain" xlink:label="loc_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:to="lab_shpgf_TermLoanDomain_FEB7358BDEA666B90A047B6AB456BF00" xlink:type="arc"/>
<link:label id="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA_terseLabel_en-US" xlink:label="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> November 2015 Facility A </link:label>
<link:label id="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA_label_en-US" xlink:label="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> November 2015 Facility A [Member] </link:label>
<link:label id="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA_documentation_en-US" xlink:label="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_November2015FacilityMember" xlink:label="loc_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:to="lab_shpgf_November2015FacilityMember_C8D00E0032380257B41B7B6AB45616CA" xlink:type="arc"/>
<link:label id="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045_terseLabel_en-US" xlink:label="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> November 2015 Facility B </link:label>
<link:label id="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045_label_en-US" xlink:label="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> November 2015 Facility B [Member] </link:label>
<link:label id="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045_documentation_en-US" xlink:label="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_November2015FacilityBMember" xlink:label="loc_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:to="lab_shpgf_November2015FacilityBMember_8CAC8F56B5641C5C224A7B6AB4583045" xlink:type="arc"/>
<link:label id="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB_verboseLabel_en-US" xlink:label="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> November 2015 Facility C </link:label>
<link:label id="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB_label_en-US" xlink:label="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> November 2015 Facility C [Member] </link:label>
<link:label id="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB_documentation_en-US" xlink:label="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_November2015FacilityCMember" xlink:label="loc_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:to="lab_shpgf_November2015FacilityCMember_5EE282948982292057D57B6AB45837DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:label id="lab_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB_label_en-US" xlink:label="lab_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Line of Credit Facility [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB" xlink:to="lab_us-gaap_LineOfCreditFacilityLineItems_81FCC33425862C24F6287B6AB45918DB" xlink:type="arc"/>
<link:label id="lab_us-gaap_DeferredFinanceCostsGross_FAA11E832D023BA700917B6AB459A39B_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsGross_FAA11E832D023BA700917B6AB459A39B" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Deferred financing costs </link:label>
<link:label id="lab_us-gaap_DeferredFinanceCostsGross_FAA11E832D023BA700917B6AB459A39B_label_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsGross_FAA11E832D023BA700917B6AB459A39B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Issuance Costs, Gross </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredFinanceCostsGross" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_FAA11E832D023BA700917B6AB459A39B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD_terseLabel_en-US" xlink:label="lab_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Swingline Facility </link:label>
<link:label id="lab_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD_label_en-US" xlink:label="lab_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Bridge Loan </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BridgeLoan" xlink:label="loc_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD" xlink:to="lab_us-gaap_BridgeLoan_058FDC8938548FA78BF17B6AB4ABCCDD" xlink:type="arc"/>
<link:label id="lab_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Facility amount outstanding </link:label>
<link:label id="lab_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36_label_en-US" xlink:label="lab_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Long-term Line of Credit </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36" xlink:to="lab_us-gaap_LineOfCredit_6F0040CB649A8637A0A37B6AB4AB9A36" xlink:type="arc"/>
<link:label id="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38_terseLabel_en-US" xlink:label="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Number of amortizing credit facilities </link:label>
<link:label id="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38_label_en-US" xlink:label="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Number of Credit Facilities </link:label>
<link:label id="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38_documentation_en-US" xlink:label="lab_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Debt Instrument, Number of Credit Facilities </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_DebtInstrumentNumberofCreditFacilities" xlink:label="loc_shpgf_DebtInstrumentNumberofCreditFacilities_5512FFDC17E59E56267A7B6AB4AB1C38" xlink:type="locator"/>
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<link:label id="lab_us-gaap_RepaymentsOfLinesOfCredit_F526E9E082701F5171F77B6AB4AB406D_terseLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLinesOfCredit_F526E9E082701F5171F77B6AB4AB406D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Repayment of revolving line of credit, long term and short term borrowings </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_F526E9E082701F5171F77B6AB4AB406D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CapitalLeaseObligations_5F8AF7F54A61EEACF70F7B6AB4ABB2A4_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalLeaseObligations_5F8AF7F54A61EEACF70F7B6AB4ABB2A4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital lease obligation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalLeaseObligations" xlink:label="loc_us-gaap_CapitalLeaseObligations_5F8AF7F54A61EEACF70F7B6AB4ABB2A4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CapitalLeaseObligations_5F8AF7F54A61EEACF70F7B6AB4ABB2A4" xlink:to="lab_us-gaap_CapitalLeaseObligations_5F8AF7F54A61EEACF70F7B6AB4ABB2A4" xlink:type="arc"/>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_8D5EF7817B48DE60E2FB677F40DD6B76_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_8D5EF7817B48DE60E2FB677F40DD6B76" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2018 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_8D5EF7817B48DE60E2FB677F40DD6B76_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_8D5EF7817B48DE60E2FB677F40DD6B76" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Next Twelve Months </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_8D5EF7817B48DE60E2FB677F40DD6B76" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_C0FA464A104A27351FB5677F40DDD9CB_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_C0FA464A104A27351FB5677F40DDD9CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2019 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_C0FA464A104A27351FB5677F40DDD9CB_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_C0FA464A104A27351FB5677F40DDD9CB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Year Two </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_C0FA464A104A27351FB5677F40DDD9CB" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2020 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Year Three </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3" xlink:to="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_349C2D58E56D527BD33E677F40DD3BB3" xlink:type="arc"/>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2021 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Year Four </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9" xlink:to="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_0D7988E4B08C42C59210677F40DD94D9" xlink:type="arc"/>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2022 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Year Five </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9" xlink:to="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_2694B9CC9AC20FEFA851677F40DD81F9" xlink:type="arc"/>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> 2023 through 2027 </link:label>
<link:label id="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Expected Future Benefit Payment, Five Fiscal Years Thereafter </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D" xlink:to="lab_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_070D4FA6984F3533D749677F40DDB48D" xlink:type="arc"/>
<link:label id="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_176DD4E353ACD981C71C2F643B275A44_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_152ECC8A79E15ED28FE4AA14A56977A5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Purchase Price Allocation </link:label>
<link:label id="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_176DD4E353ACD981C71C2F643B275A44_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_152ECC8A79E15ED28FE4AA14A56977A5" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_152ECC8A79E15ED28FE4AA14A56977A5" xlink:type="locator"/>
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<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_B69CC5CBCF9CB1FEA40A2F643B27EB97_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_DB354B9BFC74519DAF1D36389214F27C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Information </link:label>
<link:label id="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_B69CC5CBCF9CB1FEA40A2F643B27EB97_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_DB354B9BFC74519DAF1D36389214F27C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Business Acquisition, Pro Forma Information [Table Text Block] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_DB354B9BFC74519DAF1D36389214F27C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_ECDDD2AA730CDA48D8EAE12C45A0EB24_terseLabel_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_ECDDD2AA730CDA48D8EAE12C45A0EB24" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Commitments and Contingencies </link:label>
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<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_ECDDD2AA730CDA48D8EAE12C45A0EB24" xlink:type="locator"/>
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<link:label id="lab_shpgf_SeniorNotes20PercentDue2018Member_9028E4B59C91BC29848B965A51B93BB2_terseLabel_en-US" xlink:label="lab_shpgf_SeniorNotes20PercentDue2018Member_E1AF191C5DEE5FBEA9E75F4E37DFA702" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior Notes, 2.0 % due 2018 </link:label>
<link:label id="lab_shpgf_SeniorNotes20PercentDue2018Member_9028E4B59C91BC29848B965A51B93BB2_label_en-US" xlink:label="lab_shpgf_SeniorNotes20PercentDue2018Member_E1AF191C5DEE5FBEA9E75F4E37DFA702" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Senior Notes, 2.0 Percent due 2018 [Member] </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_SeniorNotes20PercentDue2018Member" xlink:label="loc_shpgf_SeniorNotes20PercentDue2018Member_E1AF191C5DEE5FBEA9E75F4E37DFA702" xlink:type="locator"/>
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<link:label id="lab_shpgf_SeniorNotes2875PercentDue2020Member_2CABD2B106F1479A93CE965A51B94B34_terseLabel_en-US" xlink:label="lab_shpgf_SeniorNotes2875PercentDue2020Member_7B8870F0EFFD5D87B3D4D801B8B608AB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior Notes, 2.875% due 2020 </link:label>
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<link:label id="lab_shpgf_SeniorNotes36PercentDue2022Member_07695C15425521024FDC965A51B9867A_terseLabel_en-US" xlink:label="lab_shpgf_SeniorNotes36PercentDue2022Member_9211762D8D5556998F3AB405E9BFD31D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior Notes, 3.6 Percent due 2022 </link:label>
<link:label id="lab_shpgf_SeniorNotes36PercentDue2022Member_07695C15425521024FDC965A51B9867A_label_en-US" xlink:label="lab_shpgf_SeniorNotes36PercentDue2022Member_9211762D8D5556998F3AB405E9BFD31D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Senior Notes, 3.6 Percent due 2022 [Member] </link:label>
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<link:label id="lab_shpgf_SeniorNotes40PercentDue2025Member_B3F5F01EABB0465D7075965A51BAFDFF_terseLabel_en-US" xlink:label="lab_shpgf_SeniorNotes40PercentDue2025Member_A33B4B62CB8B5605AEBC09D391C58D01" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Senior Notes, 4.0% due 2025 </link:label>
<link:label id="lab_shpgf_SeniorNotes40PercentDue2025Member_B3F5F01EABB0465D7075965A51BAFDFF_label_en-US" xlink:label="lab_shpgf_SeniorNotes40PercentDue2025Member_A33B4B62CB8B5605AEBC09D391C58D01" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Senior Notes, 4.0 Percent due 2025 [Member] </link:label>
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<link:label id="lab_shpgf_FixedrateNotesDue2023Member_C4176DDC213EDDA96C96965A51BADA63_terseLabel_en-US" xlink:label="lab_shpgf_FixedrateNotesDue2023Member_CC2EEC4D790B503399F80A6BB4CAC28F" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2023 </link:label>
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<link:label id="lab_shpgf_FixedrateNotesDue2026Member_5959814A3C34FBED2071965A51BA1EB9_terseLabel_en-US" xlink:label="lab_shpgf_FixedrateNotesDue2026Member_F27BC8BC708B51199B2E63DE10220CAB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Fixed-rate notes due 2026 </link:label>
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<link:label id="lab_us-gaap_SegmentReportingDisclosureTextBlock_835182FE01509C228D9CE12C458E22C6_label_en-US" xlink:label="lab_us-gaap_SegmentReportingDisclosureTextBlock_835182FE01509C228D9CE12C458E22C6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Segment Reporting Disclosure [Text Block] </link:label>
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<link:label id="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496_terseLabel_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Health care cost trend rate </link:label>
<link:label id="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496_label_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Assumptions Used Calculating Net Periodic Benefit Cost, Annual Rate Of Per Capita Cost Increase </link:label>
<link:label id="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496_documentation_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateOfPerCapitaCostIncrease_3E9B81530CA3B28F81044319B8D37496" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Assumptions Used Calculating Net Periodic Benefit Cost, Annual Rate Of Per Capita Cost Increase </link:label>
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<link:label id="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateDecreaseInPerCapitaCost_C34DB135F0BE3D4F45474319B8D38372_documentation_en-US" xlink:label="lab_shpgf_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostAnnualRateDecreaseInPerCapitaCost_C34DB135F0BE3D4F45474319B8D38372" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Defined Benefit Plan, Assumptions Used Calculating Net Periodic Benefit Cost, Annual Rate Decrease In Per Capita Cost </link:label>
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<link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_A208350624E3FED59C534D1462B78250_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_A208350624E3FED59C534D1462B78250" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts Payable and Accrued Expenses </link:label>
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<link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_DF955284AC5DE7DCC6901EF2C843F38E_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared_DF955284AC5DE7DCC6901EF2C843F38E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dividends per share declared </link:label>
<link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_DF955284AC5DE7DCC6901EF2C843F38E_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared_DF955284AC5DE7DCC6901EF2C843F38E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Dividends, Per Share, Declared </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_DF955284AC5DE7DCC6901EF2C843F38E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_DF2A785B9898C4A20B6B1EF2C8433D4E_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid_DF2A785B9898C4A20B6B1EF2C8433D4E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dividends per share paid </link:label>
<link:label id="lab_us-gaap_CommonStockDividendsPerShareCashPaid_DF2A785B9898C4A20B6B1EF2C8433D4E_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareCashPaid_DF2A785B9898C4A20B6B1EF2C8433D4E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Common Stock, Dividends, Per Share, Cash Paid </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_DF2A785B9898C4A20B6B1EF2C8433D4E" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DividendsCommonStockCash_C8F072466C3A46F2BFDC1EF2C8445D19_terseLabel_en-US" xlink:label="lab_us-gaap_DividendsCommonStockCash_C8F072466C3A46F2BFDC1EF2C8445D19" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Dividends paid (in USD) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DividendsCommonStockCash" xlink:label="loc_us-gaap_DividendsCommonStockCash_C8F072466C3A46F2BFDC1EF2C8445D19" xlink:type="locator"/>
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<link:label id="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_3B319864FF2B5608C1142F643BB4C6F5_terseLabel_en-US" xlink:label="lab_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_4D6227EAE50C5DC9AD2BBAE5B5B5E9D3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Reserve for discounts and doubtful accounts </link:label>
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<link:label id="lab_shpgf_RoyaltiesReceivable_082604C5011048EC61362F643BB4A781_terseLabel_en-US" xlink:label="lab_shpgf_RoyaltiesReceivable_F09A767B392B55D79F56CD4D727FE76B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accounts receivable related to royalty income </link:label>
<link:label id="lab_shpgf_RoyaltiesReceivable_082604C5011048EC61362F643BB4A781_label_en-US" xlink:label="lab_shpgf_RoyaltiesReceivable_F09A767B392B55D79F56CD4D727FE76B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Royalties Receivable </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_RoyaltiesReceivable" xlink:label="loc_shpgf_RoyaltiesReceivable_F09A767B392B55D79F56CD4D727FE76B" xlink:type="locator"/>
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<link:label id="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_23CDB7E0D05BDA018E5F255774C535CB_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNoteTextBlock_23CDB7E0D05BDA018E5F255774C535CB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Accumulated Other Comprehensive Income/(Loss) </link:label>
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<link:label id="lab_us-gaap_GoodwillRollForward_CD49E1FF449A00AC7C7F4DD9A982F969_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_CD49E1FF449A00AC7C7F4DD9A982F969" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
<link:label id="lab_us-gaap_GoodwillRollForward_CD49E1FF449A00AC7C7F4DD9A982F969_label_en-US" xlink:label="lab_us-gaap_GoodwillRollForward_CD49E1FF449A00AC7C7F4DD9A982F969" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill [Roll Forward] </link:label>
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<link:label id="lab_us-gaap_GoodwillAcquiredDuringPeriod_F0B7B72E1B0F4A2F285E4DD9A98201F0_verboseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAcquiredDuringPeriod_F0B7B72E1B0F4A2F285E4DD9A98201F0" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US"> Acquisitions </link:label>
<link:label id="lab_us-gaap_GoodwillAcquiredDuringPeriod_F0B7B72E1B0F4A2F285E4DD9A98201F0_label_en-US" xlink:label="lab_us-gaap_GoodwillAcquiredDuringPeriod_F0B7B72E1B0F4A2F285E4DD9A98201F0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Acquired During Period </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAcquiredDuringPeriod" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_F0B7B72E1B0F4A2F285E4DD9A98201F0" xlink:type="locator"/>
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<link:label id="lab_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_B786B4C13118D23D0E514DD9A982CEDC_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_B786B4C13118D23D0E514DD9A982CEDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Foreign currency translation and other </link:label>
<link:label id="lab_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_B786B4C13118D23D0E514DD9A982CEDC_label_en-US" xlink:label="lab_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_B786B4C13118D23D0E514DD9A982CEDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Goodwill, Translation and Purchase Accounting Adjustments </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments" xlink:label="loc_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_B786B4C13118D23D0E514DD9A982CEDC" xlink:type="locator"/>
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<link:label id="lab_us-gaap_Goodwill_FFED6AD36F6FB44BD2BB4DD9A982EC18_periodEndLabel_en-US" xlink:label="lab_us-gaap_Goodwill_FFED6AD36F6FB44BD2BB4DD9A982EC18" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US"> As of December 31, </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_FFED6AD36F6FB44BD2BB4DD9A982EC18" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill_FFED6AD36F6FB44BD2BB4DD9A982EC18" xlink:to="lab_us-gaap_Goodwill_FFED6AD36F6FB44BD2BB4DD9A982EC18" xlink:type="arc"/>
<link:label id="lab_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC_terseLabel_en-US" xlink:label="lab_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Lease and rental expense </link:label>
<link:label id="lab_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC_label_en-US" xlink:label="lab_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Operating Leases, Rent Expense </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC" xlink:to="lab_us-gaap_LeaseAndRentalExpense_60F0C2BF2DF79F8A95015397F27E54AC" xlink:type="arc"/>
<link:label id="lab_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117_terseLabel_en-US" xlink:label="lab_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Irrevocable standby letters of credit and guarantees </link:label>
<link:label id="lab_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117_label_en-US" xlink:label="lab_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Letters of Credit Outstanding, Amount </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117" xlink:to="lab_us-gaap_LettersOfCreditOutstandingAmount_ADAAF6D9330B8F1329745397F27E1117" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherCommitmentsTable_1DCD96CEAFA1E2D10C8E5397F27E778D_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCommitmentsTable_1DCD96CEAFA1E2D10C8E5397F27E778D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Commitments [Table] </link:label>
<link:label id="lab_us-gaap_OtherCommitmentsTable_1DCD96CEAFA1E2D10C8E5397F27E778D_label_en-US" xlink:label="lab_us-gaap_OtherCommitmentsTable_1DCD96CEAFA1E2D10C8E5397F27E778D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitments [Table] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCommitmentsTable" xlink:label="loc_us-gaap_OtherCommitmentsTable_1DCD96CEAFA1E2D10C8E5397F27E778D" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Commitments [Axis] </link:label>
<link:label id="lab_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21_label_en-US" xlink:label="lab_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitments [Axis] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCommitmentsAxis" xlink:label="loc_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21" xlink:to="lab_us-gaap_OtherCommitmentsAxis_E1FA4C95B97D2B5F47645397F27E9C21" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Commitments [Domain] </link:label>
<link:label id="lab_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45_label_en-US" xlink:label="lab_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitments [Domain] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCommitmentsDomain" xlink:label="loc_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45" xlink:to="lab_us-gaap_OtherCommitmentsDomain_F4030E0CAC6A344083E75397F27E9B45" xlink:type="arc"/>
<link:label id="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79_terseLabel_en-US" xlink:label="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Clinical Testing </link:label>
<link:label id="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79_label_en-US" xlink:label="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Clinical Testing [Member] </link:label>
<link:label id="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79_documentation_en-US" xlink:label="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ClinicalTestingMember" xlink:label="loc_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:to="lab_shpgf_ClinicalTestingMember_88441E31AA210C2579175397F27ECE79" xlink:type="arc"/>
<link:label id="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3_terseLabel_en-US" xlink:label="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Contract Manufacturing </link:label>
<link:label id="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3_label_en-US" xlink:label="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Contract Manufacturing [Member] </link:label>
<link:label id="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3_documentation_en-US" xlink:label="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_ContractManufacturingMember" xlink:label="loc_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:to="lab_shpgf_ContractManufacturingMember_46739C932B4FDCA9C7C05397F27EF4F3" xlink:type="arc"/>
<link:label id="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1_terseLabel_en-US" xlink:label="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Purchasing Commitment </link:label>
<link:label id="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1_label_en-US" xlink:label="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Purchasing Commitment [Member] </link:label>
<link:label id="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1_documentation_en-US" xlink:label="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_OtherPurchasingCommitmentMember" xlink:label="loc_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:to="lab_shpgf_OtherPurchasingCommitmentMember_4F82FC2DA6DF71191A965397F27E7AB1" xlink:type="arc"/>
<link:label id="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9_terseLabel_en-US" xlink:label="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Investment Commitment </link:label>
<link:label id="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9_label_en-US" xlink:label="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Investment Commitment [Member] </link:label>
<link:label id="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9_documentation_en-US" xlink:label="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_InvestmentCommitmentMember" xlink:label="loc_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:to="lab_shpgf_InvestmentCommitmentMember_8C9BEFABC62750F137055397F27E3BD9" xlink:type="arc"/>
<link:label id="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984_terseLabel_en-US" xlink:label="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Capital Commitment </link:label>
<link:label id="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984_label_en-US" xlink:label="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Capital Commitment [Member] </link:label>
<link:label id="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984_documentation_en-US" xlink:label="lab_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"/>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_CapitalCommitmentMember" xlink:label="loc_shpgf_CapitalCommitmentMember_79E5F5C29A9DCC9B06BB5397F27E5984" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherCommitmentsLineItems_2C40A710F258CD3F05FE5397F27F4595_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCommitmentsLineItems_2C40A710F258CD3F05FE5397F27F4595" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Other Commitments [Line Items] </link:label>
<link:label id="lab_us-gaap_OtherCommitmentsLineItems_2C40A710F258CD3F05FE5397F27F4595_label_en-US" xlink:label="lab_us-gaap_OtherCommitmentsLineItems_2C40A710F258CD3F05FE5397F27F4595" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitments [Line Items] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCommitmentsLineItems" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_2C40A710F258CD3F05FE5397F27F4595" xlink:type="locator"/>
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<link:label id="lab_us-gaap_OtherCommitment_4FED06C798BE2C5535775397F27F4085_label_en-US" xlink:label="lab_us-gaap_OtherCommitment_4FED06C798BE2C5535775397F27F4085" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitment </link:label>
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<link:label id="lab_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE_terseLabel_en-US" xlink:label="lab_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Commitments expected to be paid in next year </link:label>
<link:label id="lab_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE_label_en-US" xlink:label="lab_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Commitment, Due in Next Twelve Months </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCommitmentDueInNextTwelveMonths" xlink:label="loc_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE" xlink:to="lab_us-gaap_OtherCommitmentDueInNextTwelveMonths_5A0BFB6206DF75B7AD935397F27F95BE" xlink:type="arc"/>
<link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_4C1C4697ECFC7579BE968B712CAD32C3_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract_4C1C4697ECFC7579BE968B712CAD32C3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Statement of Cash Flows [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_4C1C4697ECFC7579BE968B712CAD32C3" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4C1C4697ECFC7579BE968B712CAD32C3" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract_4C1C4697ECFC7579BE968B712CAD32C3" xlink:type="arc"/>
<link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Adjustments to reconcile net income to net cash provided by operating activities: </link:label>
<link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E" xlink:to="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_251F2EF0C9C9C5CBC1B68B712CADAA2E" xlink:type="arc"/>
<link:label id="lab_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1_terseLabel_en-US" xlink:label="lab_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Depreciation and amortization </link:label>
<link:label id="lab_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1_label_en-US" xlink:label="lab_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Depreciation, Depletion and Amortization, Nonproduction </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1" xlink:to="lab_us-gaap_DepreciationAndAmortization_D77CCBFA11FC7BAADDFD8B712CAD73E1" xlink:type="arc"/>
<link:label id="lab_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Share based compensation </link:label>
<link:label id="lab_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Share-based Compensation </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D" xlink:to="lab_us-gaap_ShareBasedCompensation_DCAEB69A95809F510D068B712CADE31D" xlink:type="arc"/>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Amortization of deferred financing fees </link:label>
<link:label id="lab_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Amortization of Debt Issuance Costs </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4" xlink:to="lab_us-gaap_AmortizationOfFinancingCosts_6F3615A26E128CFED9F88B712CAD1EF4" xlink:type="arc"/>
<link:label id="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669_terseLabel_en-US" xlink:label="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Expense related to the unwind of inventory fair value adjustments </link:label>
<link:label id="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669_label_en-US" xlink:label="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Unwind of Inventory Fair Value Step Up </link:label>
<link:label id="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669_documentation_en-US" xlink:label="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> Amount of expense related to adjustment to fair value of inventory acquired though business combination. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_UnwindOfInventoryFairValueStepUp" xlink:label="loc_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:to="lab_shpgf_UnwindOfInventoryFairValueStepUp_B2E2427DE4E2191D0ED68B712CAD9669" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Change in deferred taxes </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Deferred Income Taxes </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84" xlink:to="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_836BD19E9C88F4F0A1C48B712CAD8F84" xlink:type="arc"/>
<link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6C0FE8B0AD898B37F4B98B712CAD6F2A_negatedLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6C0FE8B0AD898B37F4B98B712CAD6F2A" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Change in fair value of contingent consideration </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6C0FE8B0AD898B37F4B98B712CAD6F2A" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6C0FE8B0AD898B37F4B98B712CAD6F2A" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6C0FE8B0AD898B37F4B98B712CAD6F2A" xlink:type="arc"/>
<link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Impairment of PP&E and intangible assets </link:label>
<link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D_label_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D" xlink:to="lab_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_82A6BB611CD5C55B393B8B712CAD997D" xlink:type="arc"/>
<link:label id="lab_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0_negatedLabel_en-US" xlink:label="lab_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Other, net </link:label>
<link:label id="lab_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0_label_en-US" xlink:label="lab_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Other Noncash Income (Expense) </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0" xlink:to="lab_us-gaap_OtherNoncashIncomeExpense_181AE354D1A40391D30E8B712CADC9E0" xlink:type="arc"/>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8512F8C9AC3F8077396B8B712CAD0859_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8512F8C9AC3F8077396B8B712CAD0859" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Changes in operating assets and liabilities: </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8512F8C9AC3F8077396B8B712CAD0859_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8512F8C9AC3F8077396B8B712CAD0859" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Operating Capital [Abstract] </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8512F8C9AC3F8077396B8B712CAD0859" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Increase in accounts receivable </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Accounts Receivable </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B" xlink:type="locator"/>
<link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_45F5C1F407ACCDA5F3A38B712CADAB8B" xlink:type="arc"/>
<link:label id="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99_terseLabel_en-US" xlink:label="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Increase in sales deduction accrual </link:label>
<link:label id="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99_label_en-US" xlink:label="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Sales Deduction Accrual </link:label>
<link:label id="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99_documentation_en-US" xlink:label="lab_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US"> The net change during the reporting period in accrual for sales deductions. </link:label>
<link:loc xlink:href="shpgf-20171231.xsd#shpgf_IncreaseDecreaseInSalesDeductionAccrual" xlink:label="loc_shpgf_IncreaseDecreaseInSalesDeductionAccrual_55521C09531A16F2363E8B712CADAA99" xlink:type="locator"/>
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<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_2A37C3F473405A5F7ABE8B712CAD556C_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_2A37C3F473405A5F7ABE8B712CAD556C" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US"> Increase in inventory </link:label>
<link:label id="lab_us-gaap_IncreaseDecreaseInInventories_2A37C3F473405A5F7ABE8B712CAD556C_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories_2A37C3F473405A5F7ABE8B712CAD556C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Increase (Decrease) in Inventories </link:label>
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<link:label id="lab_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7714AD652C86B77FAA0A8B712CAD9305_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7714AD652C86B77FAA0A8B712CAD9305" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Proceeds from sale of investments </link:label>
<link:label id="lab_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7714AD652C86B77FAA0A8B712CAD9305_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7714AD652C86B77FAA0A8B712CAD9305" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Proceeds from Sale, Maturity and Collection of Short-term Investments </link:label>
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<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_F329D888F515822CE2D18B712CAD5CDC_terseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_F329D888F515822CE2D18B712CAD5CDC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Supplemental information: </link:label>
<link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_F329D888F515822CE2D18B712CAD5CDC_label_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract_F329D888F515822CE2D18B712CAD5CDC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Supplemental Cash Flow Information [Abstract] </link:label>
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<link:label id="lab_us-gaap_InterestPaid_6A88FD8B042D082169DF8B712CAD9487_label_en-US" xlink:label="lab_us-gaap_InterestPaid_6A88FD8B042D082169DF8B712CAD9487" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Interest Paid </link:label>
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<link:label id="lab_us-gaap_IncomeTaxesPaid_417E30AEA276B1D854B28B712CAD89EE_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid_417E30AEA276B1D854B28B712CAD89EE" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Income taxes paid, net </link:label>
<link:label id="lab_us-gaap_IncomeTaxesPaid_417E30AEA276B1D854B28B712CAD89EE_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid_417E30AEA276B1D854B28B712CAD89EE" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Income Taxes Paid </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_473FBBBD56028476883A8B710E82F67A_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_473FBBBD56028476883A8B710E82F67A" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> (Loss)/gain arising during the year </link:label>
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<link:label id="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossNetOfTax_8235AE0084F49EE5703F8B710E825B6B_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossNetOfTax_8235AE0084F49EE5703F8B710E825B6B" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US"> Reclassification of gain to income statement </link:label>
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<link:label id="lab_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_D95A2E6FE1D6A9E5435E2F643AD795F3_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_D8C53D55EA9D55B1B2CA895221365B95" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US"> Schedule of Inventory </link:label>
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<link:loc xlink:href="shpgf-20171231.xsd#shpgf_DeferredTaxLiabilitiesExcessOfBookValueOfAssets" xlink:label="loc_shpgf_DeferredTaxLiabilitiesExcessOfBookValueOfAssets_F6E541E03431D963FEE44DD9A82DFB8C" xlink:type="locator"/>
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<link:label id="lab_us-gaap_DeferredTaxLiabilitiesOther_74F8396CDA62A5806F814DD9A82E79F4_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesOther_74F8396CDA62A5806F814DD9A82E79F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Tax Liabilities, Other </link:label>
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<link:label id="lab_us-gaap_DeferredTaxLiabilities_EED0A828FEF74D4EA7734DD9A82E4F28_negatedTotalLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilities_EED0A828FEF74D4EA7734DD9A82E4F28" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="resource" xml:lang="en-US"> Net deferred tax liabilities </link:label>
<link:label id="lab_us-gaap_DeferredTaxLiabilities_EED0A828FEF74D4EA7734DD9A82E4F28_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilities_EED0A828FEF74D4EA7734DD9A82E4F28" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US"> Deferred Tax Liabilities, Net </link:label>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxLiabilities" xlink:label="loc_us-gaap_DeferredTaxLiabilities_EED0A828FEF74D4EA7734DD9A82E4F28" xlink:type="locator"/>
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