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Shire plc – ‘10-K’ for 12/31/17 – ‘EX-101.SCH’

On:  Friday, 2/16/18, at 6:16pm ET   ·   As of:  2/20/18   ·   For:  12/31/17   ·   Accession #:  936402-18-7   ·   File #:  1-37896

Previous ‘10-K’:  ‘10-K’ on 2/22/17 for 12/31/16   ·   Latest ‘10-K’:  This Filing

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  As Of               Filer                 Filing    For·On·As Docs:Size

 2/20/18  Shire plc                         10-K       12/31/17  168:31M

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   2.74M 
 2: EX-10.22    Material Contract                                   HTML     58K 
 3: EX-10.23    Material Contract                                   HTML     54K 
 4: EX-10.24    Material Contract                                   HTML    120K 
 5: EX-21       Subsidiaries List                                   HTML     88K 
 6: EX-23.1     Consent of Experts or Counsel                       HTML     44K 
 7: EX-23.2     Consent of Experts or Counsel                       HTML     44K 
 8: EX-31.1     Certification -- §302 - SOA'02                      HTML     50K 
 9: EX-31.2     Certification -- §302 - SOA'02                      HTML     49K 
10: EX-32.1     Certification -- §906 - SOA'02                      HTML     45K 
17: R1          Document and Entity Information                     HTML     72K 
18: R2          Consolidated Balance Sheets                         HTML    132K 
19: R3          Consolidated Balance Sheets (Parenthetical)         HTML     54K 
20: R4          Consolidated Statements of Operations               HTML    143K 
21: R5          Consolidated Statements of Comprehensive Income     HTML     85K 
22: R6          Consolidated Statements of Comprehensive Income     HTML     52K 
                (Parenthetical)                                                  
23: R7          Consolidated Statement of Changes in Equity         HTML    111K 
24: R8          Consolidated Statement of Changes in Equity         HTML     52K 
                (Parenthetical)                                                  
25: R9          Consolidated Statements of Cash Flows               HTML    144K 
26: R10         Description of Operations                           HTML     47K 
27: R11         Summary of Significant Accounting Policies          HTML    168K 
28: R12         Business Combinations                               HTML    181K 
29: R13         Collaborative and Other Licensing Arrangements      HTML     62K 
30: R14         Integration and Acquisition Costs                   HTML     71K 
31: R15         Reorganization Costs                                HTML     49K 
32: R16         Results of Discontinued Operations                  HTML     51K 
33: R17         Accounts Receivable, Net                            HTML     61K 
34: R18         Inventories                                         HTML     53K 
35: R19         Prepaid Expenses and Other Current Assets           HTML     55K 
36: R20         Property, Plant and Equipment, Net                  HTML     61K 
37: R21         Intangible Assets                                   HTML     94K 
38: R22         Goodwill                                            HTML     53K 
39: R23         Fair Value Measurement                              HTML    179K 
40: R24         Financial Instruments                               HTML    141K 
41: R25         Accounts Payable and Accrued Expenses               HTML     56K 
42: R26         Borrowings and Capital Leases                       HTML    128K 
43: R27         Other Current Liabilities                           HTML     55K 
44: R28         Retirement and Other Benefit Programs               HTML    531K 
45: R29         Accumulated Other Comprehensive Income/(Loss)       HTML    130K 
46: R30         Taxation                                            HTML    226K 
47: R31         Earnings Per Share                                  HTML     90K 
48: R32         Share-based Compensation Plans                      HTML    181K 
49: R33         Commitments and Contingencies                       HTML     65K 
50: R34         Legal and Other Proceedings                         HTML     67K 
51: R35         Shareholders' Equity                                HTML     58K 
52: R36         Segment Reporting                                   HTML    158K 
53: R37         Agreements and Transactions                         HTML     55K 
54: R38         Subsequent Events                                   HTML     47K 
55: R39         Guarantor Financial Information                     HTML   1.06M 
56: R40         Quarterly Results of Operations (Unaudited)         HTML    124K 
57: R41         Schedule II - Valuation and Qualifying Accounts     HTML    106K 
58: R42         Notes to the New Shire Income Access Share Trust    HTML     57K 
                Financial Statements                                             
59: R43         Summary of Significant Accounting Policies          HTML    257K 
                (Policies)                                                       
60: R44         Summary of Significant Accounting Policies          HTML     61K 
                (Tables)                                                         
61: R45         Business Combinations (Tables)                      HTML    150K 
62: R46         Integration and Acquisition Costs (Tables)          HTML     64K 
63: R47         Accounts Receivable, Net (Tables)                   HTML     55K 
64: R48         Inventories (Tables)                                HTML     53K 
65: R49         Prepaid Expenses and Other Current Assets (Tables)  HTML     55K 
66: R50         Property, Plant and Equipment, Net (Tables)         HTML     61K 
67: R51         Intangible Assets (Tables)                          HTML     94K 
68: R52         Goodwill (Tables)                                   HTML     52K 
69: R53         Fair Value Measurement (Tables)                     HTML    174K 
70: R54         Financial Instruments (Tables)                      HTML    134K 
71: R55         Accounts Payable and Accrued Expenses (Tables)      HTML     56K 
72: R56         Borrowings and Capital Leases (Tables)              HTML    118K 
73: R57         Other Current Liabilities (Tables)                  HTML     54K 
74: R58         Retirement and Other Benefit Programs (Tables)      HTML    519K 
75: R59         Accumulated Other Comprehensive Income/(Loss)       HTML    129K 
                (Tables)                                                         
76: R60         Taxation Taxation (Tables)                          HTML    221K 
77: R61         Earnings Per Share (Tables)                         HTML     91K 
78: R62         Share-based Compensation Plans (Tables)             HTML    158K 
79: R63         Commitments and Contingencies (Tables)              HTML     51K 
80: R64         Segment Reporting (Tables)                          HTML    164K 
81: R65         Guarantor Financial Information (Tables)            HTML    947K 
82: R66         Quarterly Results of Operations (Unaudited)         HTML    124K 
                (Tables)                                                         
83: R67         Summary of Significant Accounting Policies          HTML     79K 
                (Narrative) (Details)                                            
84: R68         Summary of Significant Accounting Policies (Useful  HTML     55K 
                Lives of Property, Plant and Equipment) (Details)                
85: R69         Business Combinations (Acquisition of Baxalta)      HTML    117K 
                (Narrative) (Details)                                            
86: R70         Business Combinations (Baxalta Purchase Price       HTML     57K 
                Consideration) (Details)                                         
87: R71         Business Combinations (Baxalta Assets Acquired and  HTML    136K 
                Liabilities Assumed) (Details)                                   
88: R72         Business Combinations (Baxalta Pro Forma            HTML     62K 
                Information) (Details)                                           
89: R73         Business Combinations (Acquisition of Dyax)         HTML    107K 
                (Narrative) (Details)                                            
90: R74         Business Combinations (Dyax Assets Acquired and     HTML    102K 
                Liabilities Assumed) (Details)                                   
91: R75         Business Combinations (Dyax Pro Forma Information)  HTML     58K 
                (Details)                                                        
92: R76         Collaborative and Other Licensing Arrangements      HTML     65K 
                (Narrative) (Details)                                            
93: R77         Integration and Acquisition Costs (Narrative)       HTML     76K 
                (Details)                                                        
94: R78         Integration and Acquisition Costs (Summary of       HTML     56K 
                Employee Termination Related Reserve and Other)                  
                (Details)                                                        
95: R79         Reorganization Costs (Narrative) (Details)          HTML     51K 
96: R80         Results of Discontinued Operations (Narrative)      HTML     70K 
                (Details)                                                        
97: R81         Accounts Receivable, Net (Narrative) (Details)      HTML     50K 
98: R82         Accounts Receivable, Net (Summary of Reserve for    HTML     53K 
                Discounts and Allowances) (Details)                              
99: R83         Inventories (Summary of Inventories) (Details)      HTML     54K 
100: R84         Prepaid Expenses and Other Current Assets           HTML     56K  
                (Details)                                                        
101: R85         Property, Plant and Equipment, Net (Summary of      HTML     61K  
                Property, Plant and Equipment) (Details)                         
102: R86         Property, Plant and Equipment, Net (Narrative)      HTML     62K  
                (Details)                                                        
103: R87         Intangible Assets (Summary of Intangible Assets)    HTML     59K  
                (Details)                                                        
104: R88         Intangible Assets (Roll Forward) (Details)          HTML     56K  
105: R89         Intangible Assets (Narrative) (Details)             HTML     60K  
106: R90         Intangible Assets (Future Amortization Expense)     HTML     54K  
                (Details)                                                        
107: R91         Goodwill (Rollforward of Goodwill) (Details)        HTML     51K  
108: R92         Fair Value Measurement (Assets and Liabilities      HTML     83K  
                Measured on a Recurring Basis) (Details)                         
109: R93         Fair Value Measurement (Assets and Liabilities      HTML     54K  
                Measure at Fair Value on Recurring Basis using                   
                Level 3 Inputs) (Details)                                        
110: R94         Fair Value Measurement (Qualitative Information     HTML     76K  
                About Liabilities Measured at Fair Value on                      
                Recurring Basis Using Level 3 Inputs) (Details)                  
111: R95         Fair Value Measurement (Financial Assets and        HTML     61K  
                Liabilities Not Measured on a Recurring Basis)                   
                (Details)                                                        
112: R96         Fair Value Measurement (Narrative) (Details)        HTML     58K  
113: R97         Financial Instruments (Summary of Derivative        HTML     59K  
                Instruments) (Details)                                           
114: R98         Financial Instruments (Narrative) (Details)         HTML     58K  
115: R99         Financial Instruments (Derivative Income Statement  HTML     65K  
                Location, Gains & Losses) (Details)                              
116: R100        Financial Instruments (Foreign Exchange Risk and    HTML     84K  
                Its Classification on Balance Sheet) (Details)                   
117: R101        Accounts Payable and Accrued Expenses (Details)     HTML     55K  
118: R102        Borrowings and Capital Leases (Short-term           HTML     61K  
                Borrowings) (Details)                                            
119: R103        Borrowings and Capital Leases (Long-term            HTML     66K  
                Borrowings) (Details)                                            
120: R104        Borrowings and Capital Leases (Maturities)          HTML     68K  
                (Details)                                                        
121: R105        Borrowings and Capital Leases (Senior Notes Issued  HTML     68K  
                by SAIIDAC) (Details)                                            
122: R106        Borrowings and Capital Leases (Senior Notes         HTML     77K  
                Related to Baxalta Acquisition) (Details)                        
123: R107        Borrowings and Capital Leases (Narrative)           HTML     88K  
                (Details)                                                        
124: R108        Other Current Liabilities (Details)                 HTML     54K  
125: R109        Retirement and Other Benefit Programs (Change in    HTML    138K  
                Benefit Obligations and Fair Value of Plan Assets)               
                (Details)                                                        
126: R110        Retirement and Other Benefit Programs (Narrative)   HTML     83K  
                (Details)                                                        
127: R111        Retirement and Other Benefit Programs (Summary of   HTML     53K  
                Funded Status of Plan) (Details)                                 
128: R112        Retirement and Other Benefit Programs (Expected     HTML     66K  
                Net Pension and OPEB Plan Payments for the Next 10               
                Years) (Details)                                                 
129: R113        Retirement and Other Benefit Programs (Summary of   HTML     62K  
                Amounts Recorded in AOCI) (Details)                              
130: R114        Retirement and Other Benefit Programs (Summary of   HTML     65K  
                Net Periodic Benefit Cost) (Details)                             
131: R115        Retirement and Other Benefit Programs               HTML     75K  
                (Weighted-Average Assumptions Used for Benefit                   
                Obligation and Net Periodic Benefit Cost)                        
                (Details)                                                        
132: R116        Retirement and Other Benefit Programs (Fair Value   HTML    146K  
                Measurements of Plan Assets) (Details)                           
133: R117        Retirement and Other Benefit Programs (Funded and   HTML     66K  
                Unfunded Statuses of Plans) (Details)                            
134: R118        Accumulated Other Comprehensive Income/(Loss)       HTML     76K  
                (Summary of Changes in Accumulated Other                         
                Comprehensive Income/(Loss)) (Details)                           
135: R119        Accumulated Other Comprehensive Income/(Loss)       HTML     90K  
                (Reclassifications from Accumulated Other                        
                Comprehensive Income) (Details)                                  
136: R120        Taxation (Narrative) (Details)                      HTML     86K  
137: R121        Taxation (Components of Pre-tax Income) (Details)   HTML     56K  
138: R122        Taxation (Pretax Income from Continuing Operations  HTML     79K  
                and Provision for Income Taxes) (Details)                        
139: R123        Taxation (Effective Income Tax Rate                 HTML    124K  
                Reconciliation, and Statutory Tax Rates) (Details)               
140: R124        Taxation (Rollforward of Unrecognized Tax           HTML     71K  
                Benefits) (Details)                                              
141: R125        Taxation (Deferred Tax Assets and Liabilities, and  HTML    101K  
                Valuation Allowances) (Details)                                  
142: R126        Taxation (Operating Loss and Tax Credit             HTML     72K  
                Carryforwards, and Their Expiration Dates)                       
                (Details)                                                        
143: R127        Earnings Per Share (Calculation of EPS) (Details)   HTML    100K  
144: R128        Earnings Per Share (Summary of Antidilutive         HTML     48K  
                Securities) (Details)                                            
145: R129        Share-based Compensation Plans (Share-based         HTML     63K  
                Compensation Expense) (Details)                                  
146: R130        Share-based Compensation Plans (Narrative)          HTML    174K  
                (Details)                                                        
147: R131        Share-based Compensation Plans (Summary of Awards   HTML     85K  
                Outstanding and Vesting Schedules) (Details)                     
148: R132        Share-based Compensation Plans (Stock Options and   HTML    107K  
                SARs) (Details)                                                  
149: R133        Share-based Compensation Plans (Performance Share   HTML     74K  
                Awards) (Details)                                                
150: R134        Share-based Compensation Plans (Fair Value          HTML     62K  
                Assumptions) (Details)                                           
151: R135        Commitments and Contingencies (Future Minimum       HTML     62K  
                Lease Payments) (Details)                                        
152: R136        Commitments and Contingencies (Narrative)           HTML     63K  
                (Details)                                                        
153: R137        Legal and Other Proceedings (Narrative) (Details)   HTML     45K  
154: R138        Shareholders' Equity (Narrative) (Details)          HTML     69K  
155: R139        Segment Reporting (Narrative) (Details)             HTML     46K  
156: R140        Segment Reporting (Revenues and Long-lived Assets   HTML     64K  
                by Geographic Location) (Details)                                
157: R141        Segment Reporting (Revenues and Accounts            HTML     65K  
                Receivable by Major Customers) (Details)                         
158: R142        Segment Reporting (Revenue by Product) (Details)    HTML    132K  
159: R143        Agreements and Transactions with Baxter             HTML     68K  
                (Narrative) (Detail)                                             
160: R144        Guarantor Financial Information (Senior Notes)      HTML     67K  
                (Details)                                                        
161: R145        Guarantor Financial Information (Consolidating      HTML    206K  
                Balance Sheets) (Details)                                        
162: R146        Guarantor Financial Information (Consolidating      HTML    218K  
                Statements of Income) (Details)                                  
163: R147        Guarantor Financial Information (Condensed          HTML    160K  
                Consolidating Statement of Cash Flows) (Details)                 
164: R148        Schedule II - Valuation and Qualifying Accounts     HTML     67K  
                (Details)                                                        
165: R149        Quarterly Results of Operations (Unaudited)         HTML     93K  
                (Details)                                                        
167: XML         IDEA XML File -- Filing Summary                      XML    308K  
166: EXCEL       IDEA Workbook of Financial Reports                  XLSX    236K  
11: EX-101.INS  XBRL Instance -- shpgf-20171231                      XML  10.49M 
13: EX-101.CAL  XBRL Calculations -- shpgf-20171231_cal              XML    470K 
14: EX-101.DEF  XBRL Definitions -- shpgf-20171231_def               XML   2.08M 
15: EX-101.LAB  XBRL Labels -- shpgf-20171231_lab                    XML   3.49M 
16: EX-101.PRE  XBRL Presentations -- shpgf-20171231_pre             XML   2.56M 
12: EX-101.SCH  XBRL Schema -- shpgf-20171231                        XSD    363K 
168: ZIP         XBRL Zipped Folder -- 0000936402-18-000007-xbrl      Zip    685K  


‘EX-101.SCH’   —   XBRL Schema — shpgf-20171231


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2128100 - Disclosure - Agreements and Transactions </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2428401 - Disclosure - Agreements and Transactions with Baxter (Narrative) (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BorrowingsAndCapitalLeases" roleURI="http://shire.com/role/BorrowingsAndCapitalLeases">
<link:definition> 2117100 - Disclosure - Borrowings and Capital Leases </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BorrowingsAndCapitalLeasesLongTermBorrowingsDetails" roleURI="http://shire.com/role/BorrowingsAndCapitalLeasesLongTermBorrowingsDetails">
<link:definition> 2417403 - Disclosure - Borrowings and Capital Leases (Long-term Borrowings) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BorrowingsAndCapitalLeasesMaturitiesDetails" roleURI="http://shire.com/role/BorrowingsAndCapitalLeasesMaturitiesDetails">
<link:definition> 2417404 - Disclosure - Borrowings and Capital Leases (Maturities) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BorrowingsAndCapitalLeasesNarrativeDetails" roleURI="http://shire.com/role/BorrowingsAndCapitalLeasesNarrativeDetails">
<link:definition> 2417407 - Disclosure - Borrowings and Capital Leases (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BorrowingsAndCapitalLeasesSeniorNotesIssuedBySaiidacDetails" roleURI="http://shire.com/role/BorrowingsAndCapitalLeasesSeniorNotesIssuedBySaiidacDetails">
<link:definition> 2417405 - Disclosure - Borrowings and Capital Leases (Senior Notes Issued by SAIIDAC) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2417406 - Disclosure - Borrowings and Capital Leases (Senior Notes Related to Baxalta Acquisition) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2417402 - Disclosure - Borrowings and Capital Leases (Short-term Borrowings) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BorrowingsAndCapitalLeasesTables" roleURI="http://shire.com/role/BorrowingsAndCapitalLeasesTables">
<link:definition> 2317301 - Disclosure - Borrowings and Capital Leases (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinations" roleURI="http://shire.com/role/BusinessCombinations">
<link:definition> 2103100 - Disclosure - Business Combinations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsAcquisitionOfBaxaltaNarrativeDetails" roleURI="http://shire.com/role/BusinessCombinationsAcquisitionOfBaxaltaNarrativeDetails">
<link:definition> 2403402 - Disclosure - Business Combinations (Acquisition of Baxalta) (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsAcquisitionOfDyaxNarrativeDetails" roleURI="http://shire.com/role/BusinessCombinationsAcquisitionOfDyaxNarrativeDetails">
<link:definition> 2403406 - Disclosure - Business Combinations (Acquisition of Dyax) (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsBaxaltaAssetsAcquiredAndLiabilitiesAssumedDetails" roleURI="http://shire.com/role/BusinessCombinationsBaxaltaAssetsAcquiredAndLiabilitiesAssumedDetails">
<link:definition> 2403404 - Disclosure - Business Combinations (Baxalta Assets Acquired and Liabilities Assumed) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsBaxaltaProFormaInformationDetails" roleURI="http://shire.com/role/BusinessCombinationsBaxaltaProFormaInformationDetails">
<link:definition> 2403405 - Disclosure - Business Combinations (Baxalta Pro Forma Information) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="BusinessCombinationsBaxaltaPurchasePriceConsiderationDetails" roleURI="http://shire.com/role/BusinessCombinationsBaxaltaPurchasePriceConsiderationDetails">
<link:definition> 2403403 - Disclosure - Business Combinations (Baxalta Purchase Price Consideration) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsDyaxAssetsAcquiredAndLiabilitiesAssumedDetails" roleURI="http://shire.com/role/BusinessCombinationsDyaxAssetsAcquiredAndLiabilitiesAssumedDetails">
<link:definition> 2403407 - Disclosure - Business Combinations (Dyax Assets Acquired and Liabilities Assumed) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsDyaxProFormaInformationDetails" roleURI="http://shire.com/role/BusinessCombinationsDyaxProFormaInformationDetails">
<link:definition> 2403408 - Disclosure - Business Combinations (Dyax Pro Forma Information) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="BusinessCombinationsTables" roleURI="http://shire.com/role/BusinessCombinationsTables">
<link:definition> 2303301 - Disclosure - Business Combinations (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CollaborativeAndOtherLicensingArrangements" roleURI="http://shire.com/role/CollaborativeAndOtherLicensingArrangements">
<link:definition> 2104100 - Disclosure - Collaborative and Other Licensing Arrangements </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CollaborativeAndOtherLicensingArrangementsNarrativeDetails" roleURI="http://shire.com/role/CollaborativeAndOtherLicensingArrangementsNarrativeDetails">
<link:definition> 2404401 - Disclosure - Collaborative and Other Licensing Arrangements (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
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<link:definition> 2124100 - Disclosure - Commitments and Contingencies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2424402 - Disclosure - Commitments and Contingencies (Future Minimum Lease Payments) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CommitmentsAndContingenciesNarrativeDetails" roleURI="http://shire.com/role/CommitmentsAndContingenciesNarrativeDetails">
<link:definition> 2424403 - Disclosure - Commitments and Contingencies (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="CommitmentsAndContingenciesTables" roleURI="http://shire.com/role/CommitmentsAndContingenciesTables">
<link:definition> 2324301 - Disclosure - Commitments and Contingencies (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedBalanceSheets" roleURI="http://shire.com/role/ConsolidatedBalanceSheets">
<link:definition> 1001000 - Statement - Consolidated Balance Sheets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedBalanceSheetsParenthetical" roleURI="http://shire.com/role/ConsolidatedBalanceSheetsParenthetical">
<link:definition> 1001501 - Statement - Consolidated Balance Sheets (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementOfChangesInEquity" roleURI="http://shire.com/role/ConsolidatedStatementOfChangesInEquity">
<link:definition> 1004000 - Statement - Consolidated Statement of Changes in Equity </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementOfChangesInEquityParenthetical" roleURI="http://shire.com/role/ConsolidatedStatementOfChangesInEquityParenthetical">
<link:definition> 1004501 - Statement - Consolidated Statement of Changes in Equity (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementsOfCashFlows" roleURI="http://shire.com/role/ConsolidatedStatementsOfCashFlows">
<link:definition> 1005000 - Statement - Consolidated Statements of Cash Flows </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementsOfComprehensiveIncome" roleURI="http://shire.com/role/ConsolidatedStatementsOfComprehensiveIncome">
<link:definition> 1003000 - Statement - Consolidated Statements of Comprehensive Income </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementsOfComprehensiveIncomeParenthetical" roleURI="http://shire.com/role/ConsolidatedStatementsOfComprehensiveIncomeParenthetical">
<link:definition> 1003501 - Statement - Consolidated Statements of Comprehensive Income (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ConsolidatedStatementsOfOperations" roleURI="http://shire.com/role/ConsolidatedStatementsOfOperations">
<link:definition> 1002000 - Statement - Consolidated Statements of Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DescriptionOfOperations" roleURI="http://shire.com/role/DescriptionOfOperations">
<link:definition> 2101100 - Disclosure - Description of Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DocumentAndEntityInformation" roleURI="http://shire.com/role/DocumentAndEntityInformation">
<link:definition> 0001000 - Document - Document and Entity Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="EarningsPerShare" roleURI="http://shire.com/role/EarningsPerShare">
<link:definition> 2122100 - Disclosure - Earnings Per Share </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsPerShareCalculationOfEpsDetails" roleURI="http://shire.com/role/EarningsPerShareCalculationOfEpsDetails">
<link:definition> 2422402 - Disclosure - Earnings Per Share (Calculation of EPS) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="EarningsPerShareSummaryOfAntidilutiveSecuritiesDetails" roleURI="http://shire.com/role/EarningsPerShareSummaryOfAntidilutiveSecuritiesDetails">
<link:definition> 2422403 - Disclosure - Earnings Per Share (Summary of Antidilutive Securities) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="EarningsPerShareTables" roleURI="http://shire.com/role/EarningsPerShareTables">
<link:definition> 2322301 - Disclosure - Earnings Per Share (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurement" roleURI="http://shire.com/role/FairValueMeasurement">
<link:definition> 2114100 - Disclosure - Fair Value Measurement </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementAssetsAndLiabilitiesMeasureAtFairValueOnRecurringBasisUsingLevel3InputsDetails" roleURI="http://shire.com/role/FairValueMeasurementAssetsAndLiabilitiesMeasureAtFairValueOnRecurringBasisUsingLevel3InputsDetails">
<link:definition> 2414403 - Disclosure - Fair Value Measurement (Assets and Liabilities Measure at Fair Value on Recurring Basis using Level 3 Inputs) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementAssetsAndLiabilitiesMeasuredOnRecurringBasisDetails" roleURI="http://shire.com/role/FairValueMeasurementAssetsAndLiabilitiesMeasuredOnRecurringBasisDetails">
<link:definition> 2414402 - Disclosure - Fair Value Measurement (Assets and Liabilities Measured on a Recurring Basis) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementFinancialAssetsAndLiabilitiesNotMeasuredOnRecurringBasisDetails" roleURI="http://shire.com/role/FairValueMeasurementFinancialAssetsAndLiabilitiesNotMeasuredOnRecurringBasisDetails">
<link:definition> 2414405 - Disclosure - Fair Value Measurement (Financial Assets and Liabilities Not Measured on a Recurring Basis) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementNarrativeDetails" roleURI="http://shire.com/role/FairValueMeasurementNarrativeDetails">
<link:definition> 2414406 - Disclosure - Fair Value Measurement (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementQualitativeInformationAboutLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingLevel3InputsDetails" roleURI="http://shire.com/role/FairValueMeasurementQualitativeInformationAboutLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingLevel3InputsDetails">
<link:definition> 2414404 - Disclosure - Fair Value Measurement (Qualitative Information About Liabilities Measured at Fair Value on Recurring Basis Using Level 3 Inputs) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FairValueMeasurementTables" roleURI="http://shire.com/role/FairValueMeasurementTables">
<link:definition> 2314301 - Disclosure - Fair Value Measurement (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FinancialInstruments" roleURI="http://shire.com/role/FinancialInstruments">
<link:definition> 2115100 - Disclosure - Financial Instruments </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="FinancialInstrumentsDerivativeIncomeStatementLocationGainsLossesDetails" roleURI="http://shire.com/role/FinancialInstrumentsDerivativeIncomeStatementLocationGainsLossesDetails">
<link:definition> 2415404 - Disclosure - Financial Instruments (Derivative Income Statement Location, Gains & Losses) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FinancialInstrumentsForeignExchangeRiskAndItsClassificationOnBalanceSheetDetails" roleURI="http://shire.com/role/FinancialInstrumentsForeignExchangeRiskAndItsClassificationOnBalanceSheetDetails">
<link:definition> 2415405 - Disclosure - Financial Instruments (Foreign Exchange Risk and Its Classification on Balance Sheet) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FinancialInstrumentsNarrativeDetails" roleURI="http://shire.com/role/FinancialInstrumentsNarrativeDetails">
<link:definition> 2415403 - Disclosure - Financial Instruments (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FinancialInstrumentsSummaryOfDerivativeInstrumentsDetails" roleURI="http://shire.com/role/FinancialInstrumentsSummaryOfDerivativeInstrumentsDetails">
<link:definition> 2415402 - Disclosure - Financial Instruments (Summary of Derivative Instruments) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FinancialInstrumentsTables" roleURI="http://shire.com/role/FinancialInstrumentsTables">
<link:definition> 2315301 - Disclosure - Financial Instruments (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="Goodwill" roleURI="http://shire.com/role/Goodwill">
<link:definition> 2113100 - Disclosure - Goodwill </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GoodwillRollforwardOfGoodwillDetails" roleURI="http://shire.com/role/GoodwillRollforwardOfGoodwillDetails">
<link:definition> 2413402 - Disclosure - Goodwill (Rollforward of Goodwill) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GoodwillTables" roleURI="http://shire.com/role/GoodwillTables">
<link:definition> 2313301 - Disclosure - Goodwill (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GuarantorFinancialInformation" roleURI="http://shire.com/role/GuarantorFinancialInformation">
<link:definition> 2130100 - Disclosure - Guarantor Financial Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GuarantorFinancialInformationCondensedConsolidatingStatementOfCashFlowsDetails" roleURI="http://shire.com/role/GuarantorFinancialInformationCondensedConsolidatingStatementOfCashFlowsDetails">
<link:definition> 2430405 - Disclosure - Guarantor Financial Information (Condensed Consolidating Statement of Cash Flows) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GuarantorFinancialInformationConsolidatingBalanceSheetsDetails" roleURI="http://shire.com/role/GuarantorFinancialInformationConsolidatingBalanceSheetsDetails">
<link:definition> 2430403 - Disclosure - Guarantor Financial Information (Consolidating Balance Sheets) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GuarantorFinancialInformationConsolidatingStatementsOfIncomeDetails" roleURI="http://shire.com/role/GuarantorFinancialInformationConsolidatingStatementsOfIncomeDetails">
<link:definition> 2430404 - Disclosure - Guarantor Financial Information (Consolidating Statements of Income) (Details) </link:definition>
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<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2430402 - Disclosure - Guarantor Financial Information (Senior Notes) (Details) </link:definition>
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<link:definition> 2330301 - Disclosure - Guarantor Financial Information (Tables) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2112100 - Disclosure - Intangible Assets </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2412405 - Disclosure - Intangible Assets (Future Amortization Expense) (Details) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2412404 - Disclosure - Intangible Assets (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="IntangibleAssetsRollForwardDetails" roleURI="http://shire.com/role/IntangibleAssetsRollForwardDetails">
<link:definition> 2412403 - Disclosure - Intangible Assets (Roll Forward) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2412402 - Disclosure - Intangible Assets (Summary of Intangible Assets) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="IntangibleAssetsTables" roleURI="http://shire.com/role/IntangibleAssetsTables">
<link:definition> 2312301 - Disclosure - Intangible Assets (Tables) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2105100 - Disclosure - Integration and Acquisition Costs </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2405402 - Disclosure - Integration and Acquisition Costs (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2405403 - Disclosure - Integration and Acquisition Costs (Summary of Employee Termination Related Reserve and Other) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="IntegrationAndAcquisitionCostsTables" roleURI="http://shire.com/role/IntegrationAndAcquisitionCostsTables">
<link:definition> 2305301 - Disclosure - Integration and Acquisition Costs (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="Inventories" roleURI="http://shire.com/role/Inventories">
<link:definition> 2109100 - Disclosure - Inventories </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="InventoriesSummaryOfInventoriesDetails" roleURI="http://shire.com/role/InventoriesSummaryOfInventoriesDetails">
<link:definition> 2409402 - Disclosure - Inventories (Summary of Inventories) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="InventoriesTables" roleURI="http://shire.com/role/InventoriesTables">
<link:definition> 2309301 - Disclosure - Inventories (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2125100 - Disclosure - Legal and Other Proceedings </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="LegalAndOtherProceedingsNarrativeDetails" roleURI="http://shire.com/role/LegalAndOtherProceedingsNarrativeDetails">
<link:definition> 2425401 - Disclosure - Legal and Other Proceedings (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="NotesToNewShireIncomeAccessShareTrustFinancialStatements" roleURI="http://shire.com/role/NotesToNewShireIncomeAccessShareTrustFinancialStatements">
<link:definition> 2132100 - Disclosure - Notes to the New Shire Income Access Share Trust Financial Statements </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="OtherCurrentLiabilities" roleURI="http://shire.com/role/OtherCurrentLiabilities">
<link:definition> 2118100 - Disclosure - Other Current Liabilities </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="OtherCurrentLiabilitiesDetails" roleURI="http://shire.com/role/OtherCurrentLiabilitiesDetails">
<link:definition> 2418402 - Disclosure - Other Current Liabilities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="OtherCurrentLiabilitiesTables" roleURI="http://shire.com/role/OtherCurrentLiabilitiesTables">
<link:definition> 2318301 - Disclosure - Other Current Liabilities (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="PrepaidExpensesAndOtherCurrentAssets" roleURI="http://shire.com/role/PrepaidExpensesAndOtherCurrentAssets">
<link:definition> 2110100 - Disclosure - Prepaid Expenses and Other Current Assets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="PrepaidExpensesAndOtherCurrentAssetsDetails" roleURI="http://shire.com/role/PrepaidExpensesAndOtherCurrentAssetsDetails">
<link:definition> 2410402 - Disclosure - Prepaid Expenses and Other Current Assets (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="PrepaidExpensesAndOtherCurrentAssetsTables" roleURI="http://shire.com/role/PrepaidExpensesAndOtherCurrentAssetsTables">
<link:definition> 2310301 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2111100 - Disclosure - Property, Plant and Equipment, Net </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="PropertyPlantAndEquipmentNetNarrativeDetails" roleURI="http://shire.com/role/PropertyPlantAndEquipmentNetNarrativeDetails">
<link:definition> 2411403 - Disclosure - Property, Plant and Equipment, Net (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2411402 - Disclosure - Property, Plant and Equipment, Net (Summary of Property, Plant and Equipment) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="PropertyPlantAndEquipmentNetTables" roleURI="http://shire.com/role/PropertyPlantAndEquipmentNetTables">
<link:definition> 2311301 - Disclosure - Property, Plant and Equipment, Net (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2131100 - Disclosure - Quarterly Results of Operations (Unaudited) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
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<link:definition> 2431402 - Disclosure - Quarterly Results of Operations (Unaudited) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="QuarterlyResultsOfOperationsUnauditedTables" roleURI="http://shire.com/role/QuarterlyResultsOfOperationsUnauditedTables">
<link:definition> 2331301 - Disclosure - Quarterly Results of Operations (Unaudited) (Tables) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2106100 - Disclosure - Reorganization Costs </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2406401 - Disclosure - Reorganization Costs (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="ResultsOfDiscontinuedOperations" roleURI="http://shire.com/role/ResultsOfDiscontinuedOperations">
<link:definition> 2107100 - Disclosure - Results of Discontinued Operations </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType id="ResultsOfDiscontinuedOperationsNarrativeDetails" roleURI="http://shire.com/role/ResultsOfDiscontinuedOperationsNarrativeDetails">
<link:definition> 2407401 - Disclosure - Results of Discontinued Operations (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType id="RetirementAndOtherBenefitPrograms" roleURI="http://shire.com/role/RetirementAndOtherBenefitPrograms">
<link:definition> 2119100 - Disclosure - Retirement and Other Benefit Programs </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2419402 - Disclosure - Retirement and Other Benefit Programs (Change in Benefit Obligations and Fair Value of Plan Assets) (Details) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="RetirementAndOtherBenefitProgramsExpectedNetPensionAndOpebPlanPaymentsForNext10YearsDetails" roleURI="http://shire.com/role/RetirementAndOtherBenefitProgramsExpectedNetPensionAndOpebPlanPaymentsForNext10YearsDetails">
<link:definition> 2419405 - Disclosure - Retirement and Other Benefit Programs (Expected Net Pension and OPEB Plan Payments for the Next 10 Years) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2419409 - Disclosure - Retirement and Other Benefit Programs (Fair Value Measurements of Plan Assets) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="RetirementAndOtherBenefitProgramsFundedAndUnfundedStatusesOfPlansDetails" roleURI="http://shire.com/role/RetirementAndOtherBenefitProgramsFundedAndUnfundedStatusesOfPlansDetails">
<link:definition> 2419410 - Disclosure - Retirement and Other Benefit Programs (Funded and Unfunded Statuses of Plans) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2419403 - Disclosure - Retirement and Other Benefit Programs (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 2419406 - Disclosure - Retirement and Other Benefit Programs (Summary of Amounts Recorded in AOCI) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2419404 - Disclosure - Retirement and Other Benefit Programs (Summary of Funded Status of Plan) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 2419407 - Disclosure - Retirement and Other Benefit Programs (Summary of Net Periodic Benefit Cost) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType id="RetirementAndOtherBenefitProgramsTables" roleURI="http://shire.com/role/RetirementAndOtherBenefitProgramsTables">
<link:definition> 2319301 - Disclosure - Retirement and Other Benefit Programs (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="RetirementAndOtherBenefitProgramsWeightedAverageAssumptionsUsedForBenefitObligationAndNetPeriodicBenefitCostDetails" roleURI="http://shire.com/role/RetirementAndOtherBenefitProgramsWeightedAverageAssumptionsUsedForBenefitObligationAndNetPeriodicBenefitCostDetails">
<link:definition> 2419408 - Disclosure - Retirement and Other Benefit Programs (Weighted-Average Assumptions Used for Benefit Obligation and Net Periodic Benefit Cost) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType id="ScheduleIiValuationAndQualifyingAccounts" roleURI="http://shire.com/role/ScheduleIiValuationAndQualifyingAccounts">
<link:definition> 2131100 - Schedule - Schedule II - Valuation and Qualifying Accounts </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="ScheduleIiValuationAndQualifyingAccountsDetails" roleURI="http://shire.com/role/ScheduleIiValuationAndQualifyingAccountsDetails">
<link:definition> 2431401 - Schedule - Schedule II - Valuation and Qualifying Accounts (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="SegmentReporting" roleURI="http://shire.com/role/SegmentReporting">
<link:definition> 2127100 - Disclosure - Segment Reporting </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="SegmentReportingNarrativeDetails" roleURI="http://shire.com/role/SegmentReportingNarrativeDetails">
<link:definition> 2427402 - Disclosure - Segment Reporting (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SegmentReportingRevenueByProductDetails" roleURI="http://shire.com/role/SegmentReportingRevenueByProductDetails">
<link:definition> 2427405 - Disclosure - Segment Reporting (Revenue by Product) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="SegmentReportingRevenuesAndAccountsReceivableByMajorCustomersDetails" roleURI="http://shire.com/role/SegmentReportingRevenuesAndAccountsReceivableByMajorCustomersDetails">
<link:definition> 2427404 - Disclosure - Segment Reporting (Revenues and Accounts Receivable by Major Customers) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="SegmentReportingRevenuesAndLongLivedAssetsByGeographicLocationDetails" roleURI="http://shire.com/role/SegmentReportingRevenuesAndLongLivedAssetsByGeographicLocationDetails">
<link:definition> 2427403 - Disclosure - Segment Reporting (Revenues and Long-lived Assets by Geographic Location) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="SegmentReportingTables" roleURI="http://shire.com/role/SegmentReportingTables">
<link:definition> 2327301 - Disclosure - Segment Reporting (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="ShareBasedCompensationPlans" roleURI="http://shire.com/role/ShareBasedCompensationPlans">
<link:definition> 2123100 - Disclosure - Share-based Compensation Plans </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="ShareBasedCompensationPlansFairValueAssumptionsDetails" roleURI="http://shire.com/role/ShareBasedCompensationPlansFairValueAssumptionsDetails">
<link:definition> 2423407 - Disclosure - Share-based Compensation Plans (Fair Value Assumptions) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType id="ShareBasedCompensationPlansNarrativeDetails" roleURI="http://shire.com/role/ShareBasedCompensationPlansNarrativeDetails">
<link:definition> 2423403 - Disclosure - Share-based Compensation Plans (Narrative) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ShareBasedCompensationPlansPerformanceShareAwardsDetails" roleURI="http://shire.com/role/ShareBasedCompensationPlansPerformanceShareAwardsDetails">
<link:definition> 2423406 - Disclosure - Share-based Compensation Plans (Performance Share Awards) (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<xsd:element abstract="true" id="shpgf_DermagraftMember" name="DermagraftMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_DevelopmentMilestoneMember" name="DevelopmentMilestoneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate" name="DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentHighRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
<xsd:element id="shpgf_DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate" name="DiscountRateUsedInDeterminingFairValueOfAcquiredInProcessResearchAndDevelopmentLowRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
<xsd:element id="shpgf_DistributableReserves" name="DistributableReserves" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_DividendsReceivedFromParent" name="DividendsReceivedFromParent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_DyaxCorpMember" name="DyaxCorpMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationAcquisitionRelatedCostsPercent" name="EffectiveIncomeTaxRateReconciliationAcquisitionRelatedCostsPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationIntraGroupItems" name="EffectiveIncomeTaxRateReconciliationIntraGroupItems" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInterestPercent" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInterestPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationOtherPermanentDifferences" name="EffectiveIncomeTaxRateReconciliationOtherPermanentDifferences" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationRepatriationForeignEarningsTaxCutsAndJobsActOf2017Percent" name="EffectiveIncomeTaxRateReconciliationRepatriationForeignEarningsTaxCutsAndJobsActOf2017Percent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationStatutoryIncomeTaxRateCombinedRate" name="EffectiveIncomeTaxRateReconciliationStatutoryIncomeTaxRateCombinedRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActof2017Percent" name="EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActof2017Percent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ElapraseMember" name="ElapraseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_EmployeeStockOwnershipPlanESOPSavingsPeriod" name="EmployeeStockOwnershipPlanESOPSavingsPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ExercisePriceRangeOneMember" name="ExercisePriceRangeOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsAfterYearSix" name="ExpirationsOfTaxBenefitCarryforwardsAfterYearSix" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFive" name="ExpirationsOfTaxBenefitCarryforwardsInYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearFour" name="ExpirationsOfTaxBenefitCarryforwardsInYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearSix" name="ExpirationsOfTaxBenefitCarryforwardsInYearSix" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearThree" name="ExpirationsOfTaxBenefitCarryforwardsInYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsInYearTwo" name="ExpirationsOfTaxBenefitCarryforwardsInYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths" name="ExpirationsOfTaxBenefitCarryforwardsNextTwelveMonths" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved" name="FairValueInputsCumulativeProbabilityOfMilestonesBeingAchieved" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts" name="FairValueInputsEstimatedQuarterlyRoyaltiesPayableOnNetSalesOfRelevantProducts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved" name="FairValueInputsPeriodsInWhichMilestonesAreExpectedToBeAchieved" nillable="true" substitutionGroup="xbrli:item" type="xbrli:gYearItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedRateNotesDue2018Member" name="FixedRateNotesDue2018Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedRateNotesDue2020Member" name="FixedRateNotesDue2020Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedRateNotesDue2022Member" name="FixedRateNotesDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedRateNotesDue2025Member" name="FixedRateNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedRateNotesDue2045Member" name="FixedRateNotesDue2045Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedrateNotesDue2019Member" name="FixedrateNotesDue2019Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedrateNotesDue2021Member" name="FixedrateNotesDue2021Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedrateNotesDue2023Member" name="FixedrateNotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_FixedrateNotesDue2026Member" name="FixedrateNotesDue2026Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_GainLossOnDispositionOfProductRights" name="GainLossOnDispositionOfProductRights" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_GattexrevestiveMember" name="GattexrevestiveMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_GeneticDiseasesMember" name="GeneticDiseasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_HematologyMember" name="HematologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_HemophiliaMember" name="HemophiliaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_HereditaryAngioedemaMember" name="HereditaryAngioedemaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ImmunoglobulinTherapiesMember" name="ImmunoglobulinTherapiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ImmunologyMember" name="ImmunologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_IncomeApproachValuationTechniqueProbabilityWeightedDiscountedCashFlowMember" name="IncomeApproachValuationTechniqueProbabilityWeightedDiscountedCashFlowMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_IncreaseDecreaseInSalesDeductionAccrual" name="IncreaseDecreaseInSalesDeductionAccrual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_InhibitorTherapiesMember" name="InhibitorTherapiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod" name="IntangibleAssetsExcludingGoodwillAcquiredDivestedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_IntangibleAssetsExcludingGoodwillByMajorClassAxis" name="IntangibleAssetsExcludingGoodwillByMajorClassAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_IntangibleAssetsExcludingGoodwillMajorClassNameDomain" name="IntangibleAssetsExcludingGoodwillMajorClassNameDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_IntangibleAssetsTranslationAdjustments" name="IntangibleAssetsTranslationAdjustments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_IntegrationAndAcquisitionCostsMember" name="IntegrationAndAcquisitionCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_IntercompanyLoanPayableCurrent" name="IntercompanyLoanPayableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_IntercompanyLoanPayableNoncurrent" name="IntercompanyLoanPayableNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_IntercompanyLoanReceivableCurrent" name="IntercompanyLoanReceivableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_IntercompanyLoanReceivableNoncurrent" name="IntercompanyLoanReceivableNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_IntercompanyPayablesCurrent" name="IntercompanyPayablesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_IntercompanyReceivableCurrent" name="IntercompanyReceivableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_InterestIncomeExpenseMember" name="InterestIncomeExpenseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_InternalMedicineMember" name="InternalMedicineMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_InvestmentCommitmentMember" name="InvestmentCommitmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_KalbitorMember" name="KalbitorMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_LargeCapCommonStockMember" name="LargeCapCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_LegalproceedingsAbstract" name="LegalproceedingsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_LialdaAndMezavantMember" name="LialdaAndMezavantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_LoanFacilityAxis" name="LoanFacilityAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_LongTermTaxRelatedIndemnificationLiabilities" name="LongTermTaxRelatedIndemnificationLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember" name="LumenaPharmaceuticalsIncAndLotusTissueRepairIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_MYDAYISMember" name="MYDAYISMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ManufacturingAndSupplyAgreementWithBaxterMember" name="ManufacturingAndSupplyAgreementWithBaxterMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_McKessonCorpMember" name="McKessonCorpMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_MidCapCommonStockMember" name="MidCapCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_NPSPharmaViropharmaDyaxandBaxaltaMember" name="NPSPharmaViropharmaDyaxandBaxaltaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_NatparanatparMember" name="NatparanatparMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_NetTransactionsWithSubsidiaries" name="NetTransactionsWithSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_NeuroscienceMember" name="NeuroscienceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_NonGuarantorNonIssuerSubsidiariesMember" name="NonGuarantorNonIssuerSubsidiariesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_NonGuarantorSubsidiariesBaxaltaMember" name="NonGuarantorSubsidiariesBaxaltaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_November2015FacilitiesAgreementMember" name="November2015FacilitiesAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_November2015FacilityBMember" name="November2015FacilityBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_November2015FacilityCMember" name="November2015FacilityCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_November2015FacilityMember" name="November2015FacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OncologyMember" name="OncologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OperationsNotYetTransferredToBaxaltaMember" name="OperationsNotYetTransferredToBaxaltaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OpthalmologyMember" name="OpthalmologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_OtherAccruedExpensesCurrent" name="OtherAccruedExpensesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherForeignJurisdictionsMember" name="OtherForeignJurisdictionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherForeignTaxAuthorityMember" name="OtherForeignTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherHoldingsMember" name="OtherHoldingsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherInternalMedicineMember" name="OtherInternalMedicineMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherNeuroscienceMember" name="OtherNeuroscienceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherPurchasingCommitmentMember" name="OtherPurchasingCommitmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OtherRoyaltiesAndRevenuesMember" name="OtherRoyaltiesAndRevenuesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_OutLicensingArrangementMember" name="OutLicensingArrangementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_PaymentOfParentDividends" name="PaymentOfParentDividends" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="shpgf_PaymentsToCollaborators" name="PaymentsToCollaborators" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_PentasaMember" name="PentasaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_PortfolioSharePlanPartBMember" name="PortfolioSharePlanPartBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_PortfolioSharePlanPartMember" name="PortfolioSharePlanPartMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_PrepaidExpensesandOtherCurrentAssetsRelatedIndemnificationLiabilities" name="PrepaidExpensesandOtherCurrentAssetsRelatedIndemnificationLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_ReceivableFromCollaboratorsMaximum" name="ReceivableFromCollaboratorsMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_ReplacementAwardsIssuedRestrictedStockMember" name="ReplacementAwardsIssuedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ReplacementAwardsIssuedStockOptionsMember" name="ReplacementAwardsIssuedStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ReplagalMember" name="ReplagalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_RestOfWorldMember" name="RestOfWorldMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_RestructuringandIntegrationCosts" name="RestructuringandIntegrationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_RevenueAccountMember" name="RevenueAccountMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_RoyaltiesReceivable" name="RoyaltiesReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_RoyaltyRightsMember" name="RoyaltyRightsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SalesMilestoneMember" name="SalesMilestoneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock" name="ScheduleOfCalculationOfNumeratorAndDenominatorInEarningsPerShare1TableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ScheduleOfFairValueAssetsAndLiabilitiesNotMeasuredOnRecurringBasisTableTextBlock" name="ScheduleOfFairValueAssetsAndLiabilitiesNotMeasuredOnRecurringBasisTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ScheduleOfProvisionForDoubtfulAccountsTableTextBlock" name="ScheduleOfProvisionForDoubtfulAccountsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ScheduleOfTradeReceivablesByMajorCustomersByReportingSegmentsTableTextBlock" name="ScheduleOfTradeReceivablesByMajorCustomersByReportingSegmentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SeniorNotes20PercentDue2018Member" name="SeniorNotes20PercentDue2018Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SeniorNotes2875PercentDue2020Member" name="SeniorNotes2875PercentDue2020Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SeniorNotes36PercentDue2022Member" name="SeniorNotes36PercentDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SeniorNotes40PercentDue2025Member" name="SeniorNotes40PercentDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SeniorNotes525PercentDue2045Member" name="SeniorNotes525PercentDue2045Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalHoldingPeriodUponVesting" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_SharesHeldByEBTMember" name="SharesHeldByEBTMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SharesHeldUnderShareBuybackProgramMember" name="SharesHeldUnderShareBuybackProgramMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SharesaveSchemeMember" name="SharesaveSchemeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ShireIncomeAccessShareTrustMember" name="ShireIncomeAccessShareTrustMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_Shp643Member" name="Shp643Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_StatementClassOfTreasuryStockAxis" name="StatementClassOfTreasuryStockAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_StockAppreciationRightsAndStockOptionsMember" name="StockAppreciationRightsAndStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_SubscriptionSharesSharesAuthorized" name="SubscriptionSharesSharesAuthorized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_SubsidiaryIssuerBaxaltaIncMember" name="SubsidiaryIssuerBaxaltaIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_SubsidiaryIssuerSAIIDACMember" name="SubsidiaryIssuerSAIIDACMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_TaxBenefitCarryforwardsHavingNoExpiration" name="TaxBenefitCarryforwardsHavingNoExpiration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="shpgf_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxLiabilityProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxLiabilityProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="shpgf_TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="shpgf_TaxCutsAndJobsActOf2017UnremittedForeignEarningsSubjectToTollTax" name="TaxCutsAndJobsActOf2017UnremittedForeignEarningsSubjectToTollTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_TermLoanDomain" name="TermLoanDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_ThirdpartyProfessionalFeesMember" name="ThirdpartyProfessionalFeesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_TreasuryStockReissued" name="TreasuryStockReissued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_USStateAndLocalTaxAuthoritiesMember" name="USStateAndLocalTaxAuthoritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_USStateTaxLossesMember" name="USStateTaxLossesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="shpgf_UnwindOfInventoryFairValueStepUp" name="UnwindOfInventoryFairValueStepUp" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="shpgf_ValuedAddedTaxPayableCurrent" name="ValuedAddedTaxPayableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="shpgf_VariableRateNotesDue2018Member" name="VariableRateNotesDue2018Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_VprivMember" name="VprivMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="shpgf_VyvanseMember" name="VyvanseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
</xsd:schema>

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