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Orchid Cellmark Inc – ‘424B5’ on 2/21/02

On: Thursday, 2/21/02 · Accession #: 927016-2-1107 · File #: 333-60582

  As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 2/21/02  Orchid Cellmark Inc               424B5                  1:185K                                   Donnelley R R & S… 07/FA

Prospectus — Rule 424(b)(5)
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 424B5       Prospectus                                            60    277K

Document Table of Contents

Page	(sequential)	\|	(alphabetic)	Top
			Alternative Formats (Word, et al.) About This Prospectus Supplement Description of Capital Stock Description of Debt Securities Description of Warrants Dilution Experts Incorporation of Certain Documents by Reference Independent Auditors' Report Legal Matters Legal Ownership of Securities Notes to Consolidated Financial Statements Offering, The Orchid BioSciences, Inc Plan of Distribution Prospectus Summary Ratio of Earnings to Fixed Charges Risk Factors Securities We May Offer, The Selling Stockholders Special Note Regarding Forward-Looking Information Special Situations When a Global Security Will Be Terminated Table of Contents The Offering The Securities We May Offer Underwriting Use of Proceeds Validity of Common Stock Where You Can Find More Information
1	1st Page - Filing Submission
2	Table of Contents
"	About This Prospectus Supplement
3	The Offering
"	Use of Proceeds
"	Dilution
4	Underwriting
6	Validity of Common Stock
7	Orchid BioSciences, Inc
9	Prospectus Summary
10	Risk Factors
21	Special Note Regarding Forward-Looking Information
22	Selling Stockholders
27	Ratio of Earnings to Fixed Charges
"	The Securities We May Offer
"	Description of Capital Stock
31	Description of Debt Securities
35	Description of Warrants
37	Legal Ownership of Securities
40	Special Situations When a Global Security Will Be Terminated
42	Plan of Distribution
43	Legal Matters
"	Experts
"	Where You Can Find More Information
44	Incorporation of Certain Documents by Reference
46	Independent Auditors' Report
51	Notes to Consolidated Financial Statements

424B5 1st Page of 60 TOC ↑Top Previous Next ↓Bottom Just 1st
Filed pursuant to Rule 424(b)(5)
Registration No. 333-60582

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED FEBRUARY 14, 2002)

[LOGO] ORCHID
BIOSCIENCES, INC.

8,000,000 Shares
Common Stock

Orchid BioSciences, Inc. is offering 8,000,000 shares of its common stock.
Orchid BioSciences, Inc.'s common stock is traded on the Nasdaq National Market
under the symbol "ORCH." The last reported sale price of the common stock on
the Nasdaq National Market on February 20, 2002 was $3.00 per share.

-----------------

Investing in our common stock involves risks.
See "Risk Factors" beginning on page 4 of the accompanying prospectus.

-----------------

[Download Table]

Per Share Total
--------- -----------

Public Offering Price............................ $2.500 $20,000,000
Underwriting Discounts and Commissions........... $0.125 $ 1,000,000
Proceeds to Orchid BioSciences, Inc.............. $2.375 $19,000,000

The Securities and Exchange Commission and any state securities regulators
have not approved or disapproved these securities, or determined if this
prospectus supplement or the accompanying prospectus are truthful or complete.
Any representation to the contrary is a criminal offense.

Orchid BioSciences, Inc. has granted the underwriter a 30-day option to
purchase up to an additional 1,200,000 shares of common stock to cover
over-allotments.

-----------------

Robertson Stephens

The date of this prospectus supplement is February 21, 2002

424B5 2nd Page of 60 TOC 1st Previous Next ↓Bottom Just 2nd
TABLE OF CONTENTS

[Download Table]

Prospectus Supplement Page
--------------------- ----

About This Prospectus Supplement............................................... S-2
The Offering................................................................... S-3
Use of Proceeds................................................................ S-3
Dilution....................................................................... S-3
Underwriting................................................................... S-4
Validity of Common Stock....................................................... S-6

Prospectus Page
---------- ----

Prospectus Summary............................................................. 3
Risk Factors................................................................... 4
Special Note Regarding Forward-Looking Information............................. 15
Selling Stockholders........................................................... 16
Use of Proceeds................................................................ 20
Ratio of Earnings to Fixed Charges............................................. 21
The Securities We May Offer.................................................... 21
Description of Capital Stock................................................... 21
Description of Debt Securities................................................. 25
Description of Warrants........................................................ 29
Legal Ownership of Securities.................................................. 31
Dilution....................................................................... 35
Plan of Distribution........................................................... 36
Legal Matters.................................................................. 37
Experts........................................................................ 37
Where You Can Find More Information............................................ 37
Incorporation of Certain Documents by Reference................................ 38
Index to Consolidated Financial Statements of GeneScreen, Inc. and Subsidiaries F-1

ABOUT THIS PROSPECTUS SUPPLEMENT

In this prospectus supplement and the accompanying prospectus, the terms
"Orchid," "we," "us" and "our" refer to Orchid BioSciences, Inc.

You should read this prospectus supplement along with the accompanying
prospectus and the information incorporated by reference in these documents
carefully before you invest. Such documents contain important information you
should consider when making your investment decision. See "Incorporation of
Certain Documents by Reference" on page 38 of the accompanying prospectus. This
prospectus supplement may add, update or change information in the prospectus.
You should rely only on the information provided in this prospectus supplement,
the accompanying prospectus or documents incorporated by reference in the
accompanying prospectus. We have not authorized anyone to provide you with
different information.

S-2

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THE OFFERING

[Enlarge/Download Table]

Common stock offered by Orchid................... 8,000,000 shares
Common stock to be outstanding after the offering 54,180,450 shares
Over-allotment option............................ 1,200,000 shares
Use of proceeds.................................. For sales and marketing activities,
technology introduction, the
commercialization of our personalized
medicine business and general
corporate purposes. See "Use of
Proceeds."
Nasdaq National Market symbol.................... ORCH

The information above is based on the number of shares of common stock
outstanding as of December 31, 2001. It does not include:

. 4,809,284 shares of common stock issuable upon the exercise of stock
options outstanding as of December 31, 2001 at a weighted average exercise
price of $5.81 per share; and

. 1,744,557 shares of common stock issuable upon the exercise of warrants
outstanding as of December 31, 2001 at a weighted average exercise price
of $4.66 per share.

USE OF PROCEEDS

We estimate that the net proceeds from the sale of the 8,000,000 shares of
common stock offered by this prospectus supplement and the accompanying
prospectus will be approximately $18,825,000, based upon an offering price of
$2.50 per share and after deducting the underwriting discounts and commissions
and our estimated offering expenses. If the underwriter exercises its
over-allotment option in full, we estimate that the net proceeds will be
approximately $21,675,000. We plan to use the proceeds from the offering to
support sales and marketing activities for our new products, the introduction
of SNP scoring technology into our identity genomics business, the
commercialization of GeneShield's personalized medicine business and general
corporate purposes.

DILUTION

If you purchase our common stock in this offering, your interest will be
diluted to the extent of the difference between the public offering price per
share and the net tangible book value per share of our common stock after this
offering. Our net tangible book value at September 30, 2001, was approximately
$73.5 million, or $1.86 per share, based on 39,539,053 shares of our common
stock outstanding. Net tangible book value per share represents our tangible
net worth (tangible assets less total liabilities) divided by the number of
shares outstanding as of September 30, 2001. After giving effect to the sale of
8,000,000 shares of common stock by us at a public offering price of $2.50 per
share, less the underwriting discounts and commissions and our estimated
offering expenses, our net tangible book value at September 30, 2001, would be
$92.3 million, or $1.94 per share. This represents an immediate increase in the
net tangible book value of $0.08 per share to existing stockholders and an
immediate dilution of $0.56 per share to investors in this offering. The
following table illustrates this per share dilution:

[Enlarge/Download Table]

Public offering price per share............................................. $2.50
Net tangible book value per share as of September 30, 2001................. $1.86
-----
Increase in net tangible book value per share attributable to new investors 0.08
-----
Net tangible book value per share after this offering....................... 1.94
-----
Dilution per share to new investors......................................... $0.56
=====

S-3

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The information above does not include:

. 4,809,284 shares of common stock issuable upon the exercise of stock
options outstanding as of December 31, 2001 at a weighted average exercise
price of $5.81 per share; and

. 1,744,557 shares of common stock issuable upon the exercise of warrants
outstanding as of December 31, 2001 at a weighted average exercise price
of $4.66 per share.

To the extent that these options and warrants are exercised, there may be
further dilution to investors. In addition, this information does not include
6,622,951 shares of common stock issued in connection with our acquisition of
Lifecodes Corporation in December 2001.

UNDERWRITING

We are offering the shares of our common stock described in this prospectus
supplement through Robertson Stephens, Inc. as underwriter. We have entered
into an underwriting agreement with Robertson Stephens. Subject to the terms
and conditions of the underwriting agreement, we have agreed to sell to
Robertson Stephens, and Robertson Stephens has agreed to purchase from us,
8,000,000 shares of our common stock at an offering price of $2.50 per share,
less the underwriting discount described on the cover page of this prospectus
supplement.

The underwriting agreement provides that Robertson Stephens must buy all of
the 8,000,000 shares of our common stock from us if it buys any of them.
Robertson Stephens will sell these shares to the public when and if it buys
them from us. Robertson Stephens is offering the shares subject to a number of
conditions, including:

. its receipt and acceptance of the shares from us; and

. its right to reject orders in whole or in part.

Robertson Stephens expects to deliver the shares to purchasers on February
26, 2002.

Over-Allotment Option. We have granted Robertson Stephens an option to buy
up to 1,200,000 additional shares of our common stock from us at the same price
per share as it is paying for the 8,000,000 shares referred to above. Robertson
Stephens may exercise this option only to the extent that it sells more than
the total number of shares referred to above. Robertson Stephens may exercise
this option at any time within 30 days after the date of this prospectus
supplement. If purchased, these additional shares will be sold by Robertson
Stephens on the same terms as those on which the other shares are sold.

Listing. Our common stock is quoted on the Nasdaq National Market under the
symbol "ORCH."

Underwriting Discounts and Commissions. The underwriting discount is the
difference between the price Robertson Stephens pays to us and the price at
which Robertson Stephens offers the shares of our common stock to the public.
The size of the underwriting discount was determined through an arms-length
negotiation between us and Robertson Stephens. The following table shows the
per share and total underwriting discount we will allow to Robertson Stephens.
These amounts are shown assuming no exercise and full exercise of Robertson
Stephens' over- allotment option described above:

[Download Table]

Total
----------------------------
Per No exercise of Full Exercise
Share Option of Option
------ -------------- -------------

Public offering price........... $2.500 $20,000,000 $23,000,000
Underwriting discount........... $0.125 $ 1,000,000 $ 1,150,000
Proceeds, before expenses, to us $2.375 $19,000,000 $21,850,000

S-4

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The maximum underwriting compensation to be received by Robertson Stephens
in connection with this offering will not exceed 8% of the maximum proceeds.

The expenses of this offering, not including the underwriting discount, are
estimated to be approximately $175,000 and will be paid by us. Expenses include
the Securities and Exchange Commission filing fee, the NASD filing fee, Nasdaq
National Market listing fees, printing expenses, legal and accounting fees,
transfer agent and registrar fees and other miscellaneous fees and expenses.

Lock-Up Agreements. Our executive officers, directors and shareholders
holding at least 5% of the outstanding shares of our common stock have agreed
not to sell or transfer any shares of our common stock for 90 days after the
closing of the offering without first obtaining the written consent of
Robertson Stephens. Specifically, these individuals have agreed not to,
directly or indirectly:

. offer to sell, contract to sell, or otherwise sell or dispose of any
shares of our common stock;

. loan, pledge or grant any rights with respect to any shares of our common
stock;

. engage in any hedging or other transaction that might result in a
disposition of shares of our common stock by anyone;

. execute any short sale of shares of our common stock, whether or not
against the box; or

. purchase, sell or grant any put or call option or other right with respect
to shares of our common stock or with respect to any security other than a
broad-based market basket or index that includes, relates to or derives
any significant part of its value from our shares.

These lock-up agreements apply to shares of our common stock and also to any
options or warrants to purchase any shares of our common stock or any
securities convertible into or exchangeable for shares of our common stock.
These lock-up agreements apply to all such securities that are owned or later
acquired by the persons executing the agreements. However, Robertson Stephens
may release any the foregoing persons from these agreements at any time during
the 90 day lock-up period, in its sole discretion and without notice, as to
some or all of the shares covered by these agreements. Currently, there are no
agreements between Robertson Stephens and any of our directors, officers or 5%
shareholders to release any of them from the lock-up agreements during such
90-day period.

Indemnification of Robertson Stephens. We will indemnify Robertson Stephens
against some civil liabilities, including liabilities under the Securities Act
of 1933, as amended, and liabilities arising from breaches of our
representations and warranties contained in the underwriting agreement. If we
are unable to provide this indemnification, we will contribute to payments
Robertson Stephens may be required to make in respect of those liabilities,
which means that we will reimburse Robertson Stephens for a portion of its
payments. The relative size of our payments will be based upon the relative
benefits received by us and Robertson Stephens from the offering of our shares.
The payment amounts may also be based on our relative degree of fault in
producing the original liability.

Dealers' Compensation. Robertson Stephens initially will offer the shares
of our common stock to the public at the price specified on the cover page of
this prospectus supplement. Robertson Stephens may allow to selected dealers a
concession of not more than $0.075 per share. Robertson Stephens may also
allow, and any other dealers may reallow, a concession of not more than $0.10
per share to some other dealers. If all of the shares are not sold at the
initial public offering price, Robertson Stephens may change the public
offering price and the other selling terms. A change in the public offering
price will not affect the amount of proceeds that we receive.

S-5

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Stabilization and Other Transactions. The rules of the Securities and
Exchange Commission generally prohibit Robertson Stephens from trading our
common stock on the open market during this offering. However, Robertson
Stephens is allowed to engage in some open market transactions and other
activities during this offering that may cause the market price of shares of
our common stock to be above or below that which would otherwise prevail in the
open market. These activities may include stabilizing transactions and short
sales and over-allotments.

. Stabilizing transactions consist of bids or purchases made by Robertson
Stephens for the purpose of preventing or slowing a decline in the market
price of our shares while this offering is in progress.

. Short sales and over-allotments occur when Robertson Stephens sells more
of our shares than it purchases from us in this offering. "Covered" shorts
are short sales made in an amount not greater than Robertson Stephens'
option to purchase additional shares from us in the offering. Robertson
Stephens may close out any covered short position either by exercising
that option to purchase shares from us or by purchasing shares in the open
market. In determining the source of shares to close out a covered short
position, Robertson Stephens will consider, among other things, the
prevailing market price per share compared to the exercise price per share
of their option. "Naked" shorts are any short sales by Robertson Stephens
in excess of its option. Robertson Stephens must close out any naked short
position by purchasing shares in the open market, potentially including
purchases made as stabilizing transactions. For this reason, a naked short
position is more likely to be created if Robertson Stephens is concerned
that there may be downward pressure on the price of our shares in the open
market after pricing that could adversely affect investors who purchase in
the offering.

If Robertson Stephens commences these activities, it may discontinue them at
any time without notice. Robertson Stephens may carry out these transactions on
the Nasdaq National Market in the over-the-counter market or otherwise.

Passive Market Making. Following the pricing of this offering, and until
the commencement of any stabilizing bid, Robertson Stephens and dealers who are
qualified market makers on the Nasdaq National Market may engage in passive
market making transactions. Passive market making is allowed during the period
when the Securities and Exchange Commission's rules would otherwise prohibit
market activity by Robertson Stephens and dealers who are participating in this
offering. Passive market makers must comply with applicable volume and price
limitations and must be identified as such. In general, a passive market maker
must display its bid at a price not in excess of the highest independent bid
for shares of our common stock; but if all independent bids are lowered below
the passive market maker's bid, the passive market maker must also lower its
bid once it exceeds specified purchase limits. Net purchases by a passive
market maker on each day are limited to a specified percentage of the passive
market maker's average daily trading volume in our common stock during a
specified period and must be discontinued when such limit is reached. Robertson
Stephens and dealers participating in this offering are not required to engage
in passive market making and may end passive market making activities at any
time.

Robertson Stephens and its affiliates have in the past and may in the future
perform financial services for us, for which they have received customary fees.

VALIDITY OF COMMON STOCK

The validity of the shares of common stock we are offering will be passed
upon for us by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston,
Massachusetts, and for the underwriter certain legal matters related to this
offering will be passed upon by Testa, Hurwitz & Thibeault, LLP of Boston,
Massachusetts. Mintz Levin and attorneys at Mintz Levin own an aggregate of
approximately 8,100 shares of our common stock.

S-6

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PROSPECTUS

12,765,535 shares

[LOGO] ORCHID BIOSCIENCES, INC.

ORCHID BIOSCIENCES, INC.

Common Stock

-----------------

We may from time to time issue up to $39,300,000 in aggregate principal
amount of our common stock, preferred stock, debt securities and/or warrants.
We will specify in the accompanying prospectus supplement the terms of the
securities being offered. We may sell these securities to or through
underwriters and also to other purchasers or through agents. We will set forth
the names of any underwriters or agents in the accompanying prospectus
supplement.

This prospectus also covers the sale by the selling stockholders listed
beginning on page 16 of 12,765,535 shares of our common stock. Such offers and
sales may be made on the Nasdaq National Market, or otherwise, at prices and on
terms then prevailing, or at prices related to the then-current market price,
or in negotiated private transactions, or by underwriters pursuant to an
underwriting agreement in customary form, or in a combination of any such
methods of sale.

We will not receive any of the proceeds from the sale of the 12,765,535
shares of common stock by the selling stockholders.

Our common stock is listed on the Nasdaq National Market under the symbol
"ORCH." On February 13, 2002, the closing sale price of our securities on the
Nasdaq National Market was $3.55 per share.

Investing in our securities involves a high degree of risk. See "Risk
Factors" beginning on page 4.

-----------------

Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is
a criminal offense.

February 14, 2002.

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-----------------

TABLE OF CONTENTS

[Download Table]

Page
----

PROSPECTUS SUMMARY................ 3
RISK FACTORS...................... 4
SPECIAL NOTE REGARDING FORWARD-
LOOKING INFORMATION............. 15
SELLING STOCKHOLDERS.............. 16
USE OF PROCEEDS................... 20
RATIO OF EARNINGS TO FIXED CHARGES 21
THE SECURITIES WE MAY OFFER....... 21
DESCRIPTION OF CAPITAL STOCK...... 21
DESCRIPTION OF DEBT SECURITIES.... 25
DESCRIPTION OF WARRANTS........... 29
[Download Table]

Page
----

LEGAL OWNERSHIP OF SECURITIES........ 31
DILUTION............................. 35
PLAN OF DISTRIBUTION................. 36
LEGAL MATTERS........................ 37
EXPERTS.............................. 37
WHERE YOU CAN FIND MORE INFORMATION.. 37
INCORPORATION OF CERTAIN DOCUMENTS BY
REFERENCE.......................... 38
INDEX TO CONSOLIDATED FINANCIAL
STATEMENTS OF GENESCREEN, INC. AND
SUBSIDIARIES....................... F-1

-----------------

You may rely only on the information contained in this prospectus. We have
not authorized anyone to provide information different from that contained in
this prospectus. This prospectus is not an offer to sell nor is it seeking an
offer to buy these securities in any jurisdiction where the offer or sale is
not permitted. The information contained in this prospectus is correct only as
of the date of this prospectus, regardless
of the time of the delivery of this prospectus or any sale of these securities.

"Orchid BioSciences", "Orchid" and other trademarks and service marks of
Orchid BioSciences, Inc. mentioned in this prospectus or incorporated herein by
reference are the property of Orchid BioSciences, Inc. All other trademarks,
trade names or service marks referred to in this prospectus or incorporated
herein by reference are the property of their respective owners.

The terms "Orchid BioSciences, Inc.", "Orchid", "we" and "our" as used in
this prospectus refer to Orchid BioSciences, Inc.

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PROSPECTUS SUMMARY

The following is only a summary. You should carefully read the more detailed
information contained in this prospectus, including information incorporated
into this prospectus by reference. Our business involves significant risks. You
should carefully consider the information under the heading "Risk Factors"
below.

About This Prospectus

This prospectus is part of a registration statement that we filed with the
SEC utilizing a "shelf" registration process. Under this shelf process, we may
sell the securities described in this prospectus in one or more offerings up to
a total dollar amount of $39,300,000. We have provided to you in this
prospectus a general description of the securities we may offer. Each time we
sell securities, we will provide a prospectus supplement that will contain
specific information about the terms of that offering. We may also add, update
or change in the prospectus supplement any of the information contained in this
prospectus. This prospectus, together with applicable prospectus supplements,
includes all material information relating to this offering.

Under the shelf process, the selling stockholders listed herein may also
sell up to a total of 12,765,535 shares of common stock under this prospectus.
The number of shares of common stock to be offered by them is set forth in the
section of this prospectus titled "Selling Stockholders". We will not receive
proceeds from any sale of common stock by selling stockholders.

Orchid BioSciences, Inc.

We are engaged in the development and commercialization of technologies,
products and services designed to measure and use information related to
genetic diversity. We expect our proprietary technologies to facilitate and
potentially accelerate the medical utility of single nucleotide polymorphisms,
or "SNPs," the most common form of genetic diversity. The pharmaceutical and
medical communities are beginning to use genetic diversity information to
facilitate the development of highly specific and efficacious drugs, to improve
the effectiveness of existing drugs and to enable the realization of
personalized medicine--prescribing the right drug for the right person at the
right dose. We sell products and services and licence technologies for SNP
Scoring and genetic diversity analyses and identify and patent midcally
important uses of SNP's. Our proprietary products and technologies are being
adopted in each of these applications, and we expect the pace of activities in
these areas to increase rapidly now that a draft human genome has been
published. Genetic diversity products also have other commercial applications
outside of the healthcare field, including forensics, paternity and other
identity testing, and for improved crop development and for livestock breeding
programs.

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RISK FACTORS

Investing in our securities involves risk. Before making an investment
decision, you should carefully consider the following risks as well as other
information we include or incorporate by reference in this prospectus. The
risks and uncertainties we have described below are not the only ones facing
our company. Additional risks and uncertainties not presently known to us or
that we currently deem immaterial may also affect our business operations.

If any of the matters included in the following risks were to occur, our
business, financial condition, results of operations, cash flows or prospects
could be materially adversely affected. In such case, the value of our
securities could decline and you could lose all or part of your investment.

Risks Related to Our Business

We are at an early stage of development and may never become profitable.

We organized our company as a Delaware corporation on March 8, 1995 and have
a short operating history. The market for the products and services that we
develop, manufacture and market, all of which are derived from genomics and
microfluidics technologies, is uncertain. We face risks related to our ability
to:

. develop, market and maintain competitive technologies, products and
services;

. anticipate and adapt to changes in our rapidly evolving markets;

. retain current collaborators and customers and attract new collaborators
and customers for our SNPware consumables and SNPstream instruments;

. implement and successfully execute our business strategy and sales and
marketing initiatives in order to increase our brand recognition for our
SNPware consumables and SNPstream instruments;

. attract, retain and motivate qualified management, technical and
scientific personnel;

. obtain additional capital to support the expenses of developing our
technologies and commercializing our SNPware consumables and SNPstream
instruments; and

. transition successfully from a company with a research focus to a company
capable of supporting commercial activities.

If we fail to adequately manage these risks, we may never become profitable
and our financial condition would suffer.

We had an accumulated deficit of $98.6 million as of December 31, 2000 and
expect to continue to incur substantial operating losses for the foreseeable
future.

We have had substantial operating losses since our inception, and we expect
our operating losses to continue for the foreseeable future. For example, we
experienced net losses of $47.9 million in 2000, $28.2 million in 1999, and
$11.5 million in 1998. As of December 31, 2000, we had an accumulated deficit
of $98.6 million. In order to further develop our SNP scoring and microfluidics
technologies as well as our genetic diversity services and Pharmaceutical Value
Creation business, we will need to incur significant expenses in connection
with our internal research and development and commercialization programs. As a
result, we expect to incur operating losses for the foreseeable future.

Fluctuations in our quarterly revenues and operating results may negatively
impact our stock price.

Our revenues and results of operations have fluctuated significantly in the
past and significant fluctuations are likely to continue in the future due to a
variety of factors, many of which are outside of our control. These factors
include:

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. the volume and timing of orders for our SNPware consumables, SNPstream
instruments and other products and services;

. changes in the mix of our products and services offered;

. the number, timing and significance of new products and services
introduced by our competitors;

. our ability to develop, market and introduce new and enhanced products and
services on a timely basis;

. changes in the cost, quality and availability of reagents and components
required to manufacture or use our products; and

. availability of commercial and government funding to researchers who use
our products and services.

Research and development costs associated with our technologies, products
and services, as well as personnel costs, marketing programs and overhead
account for a substantial portion of our operating expenses. We cannot adjust
these expenses quickly in the short term. If our revenues decline or do not
grow as anticipated, we may not be able to reduce our operating expenses
accordingly. Our failure to achieve anticipated levels of revenues could
therefore harm our operating results for a particular fiscal period. In
addition, if our operating results in some quarters fail to meet the
expectations of public market analysts or investors, the market price of our
common stock is likely to fall.

We have limited manufacturing experience and will need to acquire new
facilities to manufacture our products on a commercial scale.

We have limited manufacturing experience and currently possess only two
facilities capable of manufacturing limited quantities of our SNPware products
for both sale to our customers and internal use. To achieve the production
levels necessary for successful commercialization, we will need to continue to
scale-up our manufacturing facilities and establish automated manufacturing
capabilities. We are presently in the process of building out our manufacturing
facility to meet our manufacturing needs beyond 2001. If we are unable to
successfully scale-up our existing manufacturing capability, we may not be able
to provide our customers with the quantity of products and services they
require, which would result in reduced revenues. If any natural disaster were
to significantly damage our manufacturing facility or if other events were to
cause our operations to fail, these events could prevent us from developing and
manufacturing our products. Furthermore, we may not have adequate insurance to
cover the damage, which would adversely affect our results of operations.

We have limited sales and marketing experience, and as a result, may be unable
to compete successfully with our competitors in commercializing our potential
products and services.

We have limited experience in sales and marketing. We have only recently
established a small direct sales force and will continue to rely principally
upon a small number of employees. We also intend to market our SNP scoring and
microfluidics products and services through collaborations and distribution
agreements with pharmaceutical and biotechnology companies and DNA testing
services to governmental entities and individual consumers. We cannot assure
you that we will be able to successfully establish either a direct sales force
or distribution arrangements to market our products and services, which could
have a material adverse effect on our financial condition and business strategy.

Our technologies and initial commercial products and services may not be
commercially viable or successful, which would adversely affect our revenues.

We have not yet fully completed the development of our SNP scoring
technologies or the build-out of our ultra high-throughput MegaSNPatron
facility for SNP scoring, both of which are important elements of our business
strategy. We may not be able to successfully develop these technologies or
build-out this facility. Even if we develop these technologies or complete the
build-out of this facility, we cannot be certain that our prospective customers
will value them. We are currently developing and commercializing only a limited

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number of products based on our SNP scoring technologies. We cannot assure you
that we or our customers will be able to use these technologies to successfully
identify and score SNPs. In addition, any SNPs which we or our customers score
may not be useful in assisting pharmaceutical or diagnostic product
development. Our SNP scoring technologies are in part directed toward the role
of genes and polymorphisms in complex diseases. A limited number of companies
have developed or commercialized products based on gene discoveries and/or
polymorphisms to date. Accordingly, even if we or our customers are successful
in scoring SNPs and associating these SNPs with specific drug responses or
diseases, we cannot assure you that these discoveries will lead to the
development of therapeutic or diagnostic products. If we fail to successfully
develop our SNP scoring technologies or any commercially successful therapeutic
or diagnostic products and services based on such technologies, we may not
achieve a competitive position in the market.

Our SNP scoring technologies involve novel uses of instrumentation, software
and technologies that require validation in commercial applications. Previously
unrecognized defects or limitations of our SNP scoring technologies may become
apparent in these commercial applications. As a result, we may be unable to
validate or achieve the improvements in the components of our SNP scoring
technologies necessary for their successful commercialization.

If our customers do not purchase significant volumes of SNPware consumables,
our rapid commercialization strategy could fail.

Our customers may not generate sufficient data in a cost-effective manner
using our SNPstream line of products and services. This may limit their
purchases of our SNPware consumables necessary to conduct SNP scoring with our
SNPstream systems. Other factors which may limit the use of our kits and
consumables include the acceptance of our technologies by our customers and the
training of our customers' personnel. If our customers are slow to, or never,
achieve sufficient results using our SNPstream system, or fail to purchase
sufficient quantities of our SNPware consumables, we may never achieve
profitability. Further, our customers may not adopt SNPware consumables for use
with their own instrument systems. Even if they do, our products may not work
on their systems. Either circumstance would materially and adversely affect our
revenues and our rapid commercialization strategy.

If we fail to maintain the DNA testing contracts we have with various state and
governmental agencies or fail to enter into additional contracts, we would lose
a significant source of revenues.

We currently derive a substantial portion of our revenues from the DNA
testing services we provide in the paternity and forensic fields. These
services are heavily dependent upon contracts we have with various governmental
agencies, which are typically open to bid and awarded every one to three years.
The process and criteria for these awards are typically complex and highly
competitive. We may not be able to maintain any of our existing governmental
contracts or be the successful bidder on any additional governmental contracts
which may become available in the future, or negotiate terms acceptable to us
in connection with any governmental contract awarded to us, which would
adversely affect our results of operations and financial condition.

We will require additional capital to fund our future operating plans which may
not be available on acceptable terms, if at all.

We anticipate that our existing capital resources may not be sufficient to
fund our future operating plans and we may therefore need to raise significant
additional capital. We expect our capital and operating expenses to be
significant for the foreseeable future. We have expended significant resources
to date in developing our MegaSNPatron facility and expect to continue to
expend significant resources to develop this facility, increase our research
and development and commercialization activities and acquire additional
manufacturing facilities. The amount of additional capital which we will need
to raise will depend on many factors, including:

. our progress with research and development;

. the number and breadth of our research programs;

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. our internal use of and our level of success in selling our SNP scoring
products and associated technologies and services;

. our ability to establish and maintain successful collaborations; and

. the costs incurred by us in enforcing and defending our patent claims and
other intellectual property rights.

We believe the cash on hand will be sufficient to fund our operating costs
for at least the next 12 months. However, we may need additional financing
sooner if we:

. decide to expand faster than planned;

. develop new or enhanced services or products ahead of schedule;

. need to respond to competitive pressures; or

. decide to acquire complementary products, businesses or technologies.

If we raise additional funds through the sale of equity or convertible debt
or equity-linked securities, your percentage ownership in the company will be
reduced. In addition, these transactions may dilute the value of our
outstanding common stock. We may issue securities that have rights, preferences
and privileges senior to our common stock. If we raise additional funds through
collaborations or licensing arrangements, we may be forced to relinquish rights
to certain of our technologies or products, or grant licenses to third parties
on terms that are unfavorable to us. We may be unable to raise additional funds
on terms acceptable to us. If future financing is not available to us on
acceptable terms, we may not be able to fund our future needs which would have
a material adverse effect on our results of operations and financial condition.

If we cannot enter into new collaborations or licensing agreements, we may be
unable to develop or commercialize our technologies, products and services.

Our strategy for developing and commercializing technologies, products and
services based on our discoveries depends upon our ability to form research
collaborations and licensing arrangements. As a result, we may be dependent on
our collaborators and licensees for marketing of SNP scoring systems,
regulatory approval and manufacturing and marketing of therapeutic and
diagnostic products resulting from the application of our technologies. If we
are unable to enter into such research collaborations and licensing
arrangements or implement our strategy to develop and commercialize therapeutic
and diagnostic products based upon our discoveries it would have a material
adverse effect on our results of operation and financial condition.

The early termination of any of our collaborations or licenses could harm our
business and financial condition.

The collaboration agreements we have with third parties may be terminated
early under certain circumstances, including in the event of a material breach
by us. In addition, we intend to enter into additional collaborations and
licenses with third parties, who may require that we allow them to terminate
their agreements with us prior to the expiration of the negotiated term under
certain circumstances. If any third party were to terminate its agreement with
us or otherwise fail to perform its obligations or to complete them in a timely
manner, we could lose significant revenues.

We may not be able to attract and retain consultants and scientific advisors.

We have historically maintained relationships with consultants and
scientific advisors at academic and other institutions who have conducted
research on our behalf critical to the development of our technologies,
products and services. The majority of these individuals have commitments to
other entities and have limited time available for us. Some of these entities
may also compete with us. We will need to establish new relationships with
consultants and scientific advisors in our genetic diversity fields. We will
have little, if any,

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control over the activities of any new collaborators and can expect only
limited amounts of their time to be dedicated to our activities. Our ability to
discover and score SNPs and commercialize products based on these discoveries
will depend in part on continued collaborations with researchers at academic
and other institutions. We cannot assure you that any of our existing
collaborations will be successful. Further, we may not be able to negotiate
acceptable collaborations in the future with additional consultants or
scientific advisors at academic and other institutions.

If we do not successfully distinguish and commercialize our technologies,
products and services, we may be unable to compete successfully with our
competitors or to generate significant revenues.

We are subject to significant competition from companies that are pursuing
products and services that are substantially similar to our existing and
proposed products and services. Many of the organizations competing with us
have greater financial, manufacturing, marketing, sales distribution and
technical resources than we do. In the SNP scoring field, we compete with
several companies offering alternative technologies based on indirect detection
of hybridization and/or labeling which differ in certain of the methods of
amplification, separation of samples or detection and analysis of SNPs. We may
also compete against certain of our customers, which could adversely affect our
relationships with them.

We also face significant competition in our Pharmaceutical Value Creation
efforts to identify and patent medically important uses of SNPs. Many of the
organizations competing with us have greater financial and technical resources.
We also have limited experience working in the pharmaceutical industry and may
not be able to successfully commercialize our inventions, either on our own or
in partnership with others. It also may take longer than currently anticipated
for SNPs and pharmacogenetics to become widely used in clinical practice, which
could adversely impact our ability to realize significant revenues from our PVC
business in the foreseeable future.

We believe our future success will depend, in large part, on our ability to
maintain a competitive position in the instrument and kit-based SNP scoring,
pharmacogenetics and microfluidics product fields and in the SNP scoring
services field. Others may make rapid technological developments which may
result in our technologies, products or services becoming obsolete, before we
recover the expenses incurred to develop them. Our inability to make the
enhancements to our technologies necessary to compete successfully with newly
emerging technologies would have a material adverse effect on our competitive
position.

If we are unable to protect our proprietary methods and technologies, we may
not be able to commercialize our products and services.

If our patent applications do not result in issued patents, our competitors
may obtain rights to commercialize our discoveries, which would harm our
competitive position.

Our commercial success will depend, in large part, on our ability to obtain
patent protection on many aspects of our business, technologies, products and
services, including the discovery and the association of particular SNPs with
disease predisposition and adverse drug metabolism, and on the products,
methods and services we develop. We may not be able to obtain new patents for
our SNPware consumables and SNPstream systems. We intend to apply for patent
protection on novel SNPs of known genes and their uses, as well as novel uses
for previously identified SNPs discovered by third parties. In the latter
cases, we would need a license from the holder of the patent with respect to
such SNP in order to make, use or sell any related products. We may not be able
to acquire such licenses on terms acceptable to us, if at all.

Certain parties are attempting to rapidly identify and characterize genes
and SNPs through the use of gene expression analysis and other technologies. To
the extent any patents issue to other parties on such partial or full-length
genes or SNPs or uses for such genes or SNPs, the risk increases that the sale
of products, including therapeutics, or processes developed by us or our
collaborators may give rise to claims of patent infringement

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against us. Others may have filed and, in the future are likely to file, patent
applications covering SNP uses. Any such patent application could have priority
over our patent applications and could further require us to obtain rights to
previously issued patents covering SNP uses. We cannot assure you that any
license that we may require under any such patents will be made available to us
on commercially acceptable terms, if at all.

The scope of our issued patents may not provide us with adequate protection
of our intellectual property, which would harm our competitive position.

Any issued patents that cover our proprietary technologies may not provide
us with substantial protection or be commercially beneficial to us. The
issuance of a patent is not conclusive as to its validity or its
enforceability. The US Patent and Trademark Office may invalidate one or more
of our patents. In addition, third parties may have patents of their own which
could, if asserted, prevent us from practicing our proprietary technologies,
including the methods we use to conduct SNP scoring. If we are otherwise unable
to practice our patented technologies, we may not be able to commercialize our
technologies, products or services and our competitors could commercialize our
technologies.

Our success will depend partly on our ability to operate without
misappropriating the intellectual property rights of others.

We may be sued for infringing, or may initiate litigation to determine that
we are not infringing, on the intellectual property rights of others. For
example, we have recently commenced an action against St. Louis University
seeking declaratory judgment of non-infringement, invalidity and
non-enforcement with respect to a patent controlled by St. Louis University.
Intellectual property litigation is costly, and could adversely affect our
results of operations. If we do not prevail in any intellectual property
litigation, in addition to any damages we might have to pay, we could be
required to stop the infringing activity, or obtain a license to or design
around the intellectual property in question. If we are unable to obtain a
required license on acceptable terms, or are unable to design around any third
party patent, we may be unable to sell some of our products and services, which
would result in reduced revenues.

We may need to initiate lawsuits to protect or enforce our patents and other
intellectual property rights, which could result in the forfeiture of these
rights.

In order to protect or enforce our patent rights, we may need to initiate
patent litigation against third parties. These lawsuits could be expensive,
take significant time, and could divert management's attention from other
business concerns. These lawsuits could result in the invalidation or a
limitation in the scope of our patents or forfeiture of the rights associated
with our patents. We cannot assure you that we will prevail in the St. Louis
University action or in any future litigation or that a court will not find
damages or award other remedies in favor of the opposing party in any of these
suits. During the course of these suits, there may be public announcements of
the results of hearings, motions and other interim proceedings or developments
in the litigation. Securities analysts or investors may perceive these
announcements to be negative, which would likely cause the market price of our
stock to decline.

Other rights and measures that we rely upon to protect our intellectual
property may not be adequate to protect our products and services and could
reduce our ability to compete in the market.

In addition to patents, we rely on a combination of trade secrets, copyright
and trademark laws, non-disclosure agreements and other contractual provisions
and technical measures to protect our intellectual property rights. While we
require employees, collaborators, consultants and other third parties to enter
into confidentiality and/or non-disclosure agreements where appropriate, any of
the following could still occur:

. the agreements may be breached;

. we may have inadequate remedies for any breach;

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. proprietary information could be disclosed to our competitors; or

. others may independently develop substantially equivalent proprietary
information and techniques or otherwise gain access to our trade secrets
or disclose such technologies.

If for any of the above reasons our intellectual property is disclosed or
misappropriated, it would harm both our ability to protect our rights and our
competitive position.

Future acquisitions or investments could disrupt our ongoing operations,
increase our expenses and adversely affect our revenues.

Since September 1998, we have acquired Molecular Tool, a developer of SNP
technologies, as well as GeneScreen and Cellmark, both providers of genetic
diversity testing services. Although we have no commitments or agreements with
respect to any additional acquisitions at present, we anticipate that a portion
of our future growth may be accomplished by acquiring existing businesses.
Factors that will affect the success of any acquisition we might make include
our ability to integrate acquired personnel, operations, products and
technologies into our organization effectively, to motivate key personnel and
to retain customers of acquired businesses. We may not be able to identify
suitable acquisition opportunities, obtain any necessary financing for such
acquisitions on acceptable terms or successfully integrate acquired personnel
and operations. These difficulties could disrupt our ongoing business, distract
our management and employees, increase our expenses and materially and
adversely affect our revenues.

Our failure to comply with applicable government and industry regulations may
affect our ability to develop, produce, or market our potential products and
services and may adversely affect our results of operations.

Our research and development, manufacturing and service activities involve
the controlled use of hazardous materials and chemicals and patient samples. We
are subject to federal, state, local, UK and European laws and regulations
governing the use, storage, handling and disposal of such materials and certain
waste products, as well as the conveyance, processing, and storage of and data
on patient samples. Further, we are subject to CLIA as a result of our recent
acquisition of three GeneScreen laboratories and the Cellmark laboratory. CLIA
imposes certain certification requirements on all clinical laboratories
performing tests on human specimens for the purpose of providing information
for the diagnosis, prevention or testing of any diseases. In addition, we are
subject to the European Directive 98/79/EC as a result of our acquisition of
the Cellmark Laboratory. European Directive 98/79/EC imposes certain
requirements in connection with Cellmark's sale of gene diagnostic kits.
Although we believe we comply in all material respects with the standards
prescribed by federal, state, local, UK and European laws and regulations, if
we fail to comply with applicable laws or regulations, including CLIA and
European Directive 98/79/EC, or if an accident occurs, we could be required to
pay penalties or be held liable for any damages that result and this liability
could exceed our financial resources.

All three of our GeneScreen laboratories must comply with various industry
regulations and accreditation standards in order to continue to provide our
paternity testing, forensic testing and bone marrow typing services. For
example, our GeneScreen laboratories have obtained accreditation from the
American Association of Blood Bank in order to provide paternity testing, from
the National Forensic Science Testing Center in order to provide criminal
forensic testing services and from the American Society of Histocompatibility
and Immunology in order to provide bone marrow donor typing services. In
addition, our Cellmark laboratory must comply with various industry regulations
and accreditation standards in order to provide paternity and forensic testing
services. For example, our Cellmark laboratory has obtained accreditation from
a Notified Body (SGC Yarsley ICS) and the United Kingdom Accreditation Service
and a registration from the Ministry of Agriculture, Fisheries and Food in
order to provide paternity and forensic testing services. In addition, Cellmark
must comply with regulations applicable to the marking of its products. We
cannot assure you that we will be able to maintain our accreditations with any
of these authorities or comply with the regulations

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applicable to the marking of Cellmark products. If we fail to comply with the
applicable regulations promulgated by any of these agencies or if we were to
lose our accreditation by any of them, the relevant authority could require us
to close our laboratories, which could eliminate or significantly reduce the
revenues supporting our GeneScreen or Cellmark business.

The sale of our SNPware consumables and SNPstream instruments involves a
lengthy and expensive sales cycle that may not result in sales.

Our ability to obtain customers for our SNPware consumables and SNPstream
instruments will depend in significant part upon the perception that our
products and services can help accelerate or improve drug discovery and
development efforts or have beneficial effects on human health. Our average
sales cycle is lengthy due to the education effort that is required to
effectively sell the benefits of our products and services to a variety of
constituencies within prospective customers, including research and development
personnel and key management. As a result, in many instances we may expend
significant human and capital resources to market our products without any
resulting sales.

If our customers fail to accurately prepare DNA samples for use with our
SNPware and SNPstream product line or for analysis at our MegaSNPatron
facility, our products and services may fail to produce accurate results.

Before using our SNPstream product line and MegaSNPatron SNP scoring service
facility, customers must prepare samples by following several steps that are
prone to human error, including DNA isolation and DNA segment amplification. If
they do not prepare DNA samples appropriately, our SNPstream products and
MegaSNPatron SNP scoring service will not generate an accurate reading.
Alternatively, they may achieve lower levels of throughput than the levels for
which our system was designed. If our customers generate inaccurate readings or
are unable to achieve expected levels of throughput, they may not continue to
purchase our consumables, instruments or services, which could materially and
adversely affect our revenues.

We may be held liable for any inaccuracies associated with our research and DNA
testing services, which may require us to defend ourselves in costly litigation.

Our clinical laboratory testing centers provide pharmacogenetic, forensic
and paternity testing services. Claims may be brought against us for false
identification of paternity or other inaccuracies. Litigation of these claims
can be costly. We could expend significant funds during any litigation
proceeding brought against us. Further, if a court were to require us to pay
damages to a plaintiff, the amount of such damages could significantly harm our
financial condition.

If our vendors fail to supply us with components for which availability is
limited, we may experience delays in our product development and
commercialization.

Certain key components of our SNP scoring and microfluidic chip system
technologies are currently available only from a single source or a limited
number of sources. We currently rely on outside vendors to manufacture certain
components of our SNPstream system and certain reagents we provide in our
SNPware kits. Some or all of these key components may not continue to be
available in commercial quantities at acceptable costs. For example, we have an
agreement with Beckman Coulter under which they supply us with the components
of our SNPstream system, and with NEN Life Sciences (now known as PerkinElmer)
under which they supply us with some of the key reagents contained in our
SNPware kits. We rely on third parties to provide DNA samples to us and to
perform DNA synthesis. It could be time consuming and expensive for us to seek
alternative sources of supply. Consequently, if any events cause delays or
interruptions in the supply of our components, we may not be able to supply our
customers with our products and services on a timely basis which would
adversely affect our results of operations. We also currently rely on DNA and
oligonucleotides provided by suppliers and rely on other third parties to
perform DNA synthesis for us. A steady supply of

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oligonucleotides is essential for both our internal and our external scoring
needs. The market for custom oligonucleotide synthesis is dominated by only six
producers of oligonucleotides. We currently have one source of supply for our
oligonucleotides and our business and financial condition would be adversely
affected if our existing supplier were to fail to provide us with the quantity
or quality of components we require in order to perform obligations under our
agreements with third parties in a timely manner. To the extent that our
supplier fails to meet our requirements completely or consistently, we may need
to enter a new agreement with another supplier, the terms of which may not be
as favorable toward us as our existing supply agreement.

If we fail to retain our key personnel and hire, train and retain qualified
employees, we may not be able to compete effectively, which could result in
reduced revenues.

Our future success will depend on the continued services and on the
performance of our senior management, in particular the services of:

. Dale R. Pfost, Ph.D., our Chairman of the Board, President and Chief
Executive Officer; and

. Donald R. Marvin, our Senior Vice President, Chief Operating Officer and
Chief Financial Officer.

If either of Dr. Pfost or Mr. Marvin were to be hired away from us by a
competitor, or if for any reason they could not continue to work for us, we
would have difficulty hiring officers with equivalent skills in general and
financial management. We do not currently carry "key man" life insurance, so
the loss of the services of either of these individuals could seriously impair
our ability to operate or to compete in our industry.

In addition, our researchers, scientists and technicians have significant
experience in research and development related to genetic diversity. If we were
to lose these employees to our competitors, we could spend a significant amount
of time and resources to replace them, which could impair our research and
development efforts. Further, in order to scale-up our manufacturing capability
and to further our research and development efforts, we will need to hire,
train, and retain additional research, scientific, and technical personnel. If
we are unable to do so, we may experience delays in the research, development
and commercialization of our technologies, products and services.

Risks Related to the Biotechnology Industry

Public opinion regarding ethical issues surrounding the use of genetic
information may adversely affect demand for our products.

Public opinion regarding ethical issues related to the confidentiality and
appropriate use of genetic testing results may influence governmental
authorities to call for limits on, or regulation of the use of, genetic
testing. In addition, such authorities could prohibit testing for genetic
predisposition to certain conditions, particularly for those that have no known
cure. Any of these scenarios could reduce the potential markets for our
products, which could materially and adversely affect our revenues.

Commercializing pharmaceutical products has associated risks, including
compliance with pre-clinical and clinical testing and manufacturing regulations.

Although it is likely to be years before we develop any potential
pharmaceutical products, any future products will require significant research,
development and pre-clinical and clinical testing before we submit any
regulatory application for their commercial use. If we were to undertake any of
these activities without the collaboration of others, we would have to expend
significant funds. Any of our potential pharmaceutical products will be subject
to the risks of failure inherent in the development of pharmaceutical products
based on new technologies. These risks include the following possibilities:

. that potential pharmaceutical products will be found to be unsafe,
non-efficacious or otherwise fail to receive necessary regulatory
clearances;

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. that the products, if safe and efficacious, will be difficult to
manufacture on a large scale or uneconomical to market;

. that proprietary rights of third parties will preclude us or our
collaborative partners from marketing such products; or

. that third parties will market superior or equivalent products.

If we have difficulty managing these risks, we may not be able to develop
any commercially viable products. In addition, clinical trials or marketing of
any such potential pharmaceutical products may expose us to liability claims
from the use of such pharmaceutical products. We may not be able to obtain
product liability insurance or, even if we do, any coverage we obtain could be
insufficient or costly. In addition, should we choose to manufacture or to
develop pharmaceutical products ourselves, we will have to make significant
investments in pharmaceutical product development, marketing, sales and
regulatory compliance resources, and we will have to establish or contract for
the manufacture of products under the regulations of the FDA regarding good
manufacturing practices. We cannot assure you that we will be able to develop
or commercialize successfully any potential pharmaceutical products.

Risks Associated With Our Common Stock

Future issuance of our preferred stock may dilute the rights of our common
stockholders.

Our Board of Directors has the authority to issue up to 5,000,000 shares of
preferred stock and to determine the price, privileges and other terms of these
shares. The Board of Directors may exercise this authority without any further
approval of our stockholders. The rights of the holders of common stock may be
adversely affected by the rights of the holders of our preferred stock that may
be issued in the future.

We have various mechanisms in place that you as a stockholder may not consider
favorable, which may discourage takeover attempts.

Certain provisions of our certificate of incorporation and by-laws, as well
as Section 203 of the Delaware General Corporation Law, may discourage, delay
or prevent a change in control of our company, even if the change of control
would be beneficial to stockholders. These provisions include:

. authorizing the issuance of "blank check" preferred stock that could be
designated and issued by our Board of Directors to increase the number of
outstanding shares and thwart a takeover attempt;

. creating a classified Board of Directors with staggered, three-year terms,
which may lengthen the time required to gain control of our Board of
Directors;

. prohibiting cumulative voting in the election of directors, which will
allow a majority of stockholders to control the election of all directors;

. requiring super-majority voting to effect certain amendments to our
certificate of incorporation and by-laws;

. limiting who may call special meetings of stockholders;

. prohibiting stockholder action by written consent, which requires all
actions to be taken at a meeting of stockholders; and

. establishing advance notice requirements for nominations of candidates for
election to the Board of Directors or for proposing matters that can be
acted upon by stockholders at stockholder meetings.

In addition, our stock incentive plans may discourage, delay or prevent a
change in control of our company.

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Our stock price has been and likely will continue to be volatile and your
investment may suffer a decline in value.

The market prices for securities of companies quoted on The Nasdaq Stock
Market, including our own, have in the past been, and are likely to continue in
the future to be, very volatile. The Nasdaq Composite Index has significantly
declined since our initial public offering in May 2000 and remains very
volatile with the decline and volatility of market prices for securities of
companies quoted on The Nasdaq Stock Market. The market price of our common
stock has been and likely will continue to be subject to substantial volatility
depending upon many factors, many of which are beyond our control, including:

. announcements regarding the results of discovery efforts by us or our
competitors;

. announcements regarding the acquisition of technologies or companies by us
or our competitors;

. changes in our existing strategic alliances or licensing arrangements or
formation of new alliances or arrangements;

. technological innovations or new commercial products developed by us or
our competitors;

. changes in our intellectual property portfolio;

. developments or disputes concerning our proprietary rights;

. issuance of new or changed securities analysts' reports and/or
recommendations applicable to us;

. additions or departures of our key personnel;

. operating losses by us;

. actual or anticipated fluctuations in our quarterly financial and
operating results and degree of trading liquidity in our common stock;

. continued economic uncertainty with respect to valuation of certain
technology companies and other market conditions.

We cannot assure you that your initial investment in our common stock will
not fluctuate significantly. One or more of these factors could significantly
harm our business and cause a decline in the price of our common stock in the
public market, which would adversely affect our business and financial
operations.

Our directors, executive officers and principal stockholders will have
substantial control over our affairs.

As of December 31, 2000, our directors, executive officers and principal
stockholders beneficially own, in the aggregate, approximately 34% of our
common stock. These stockholders, acting together, will have the ability to
exert substantial influence over all matters requiring approval by our
stockholders. These matters include the election and removal of our directors
and any merger, consolidation or sale of all or substantially all of our
assets. In addition, they may dictate the management of our business and
affairs. This concentration of ownership could have the effect of delaying,
deferring or preventing a change in control, or impeding a merger or
consolidation, takeover or other business combination of which you might
otherwise approve.

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SPECIAL NOTE REGARDING FORWARD-LOOKING INFORMATION

This prospectus, any prospectus supplement, and the documents incorporated
by reference in this prospectus contain "forward-looking statements" within the
meaning of Section 27A of the Securities Act of 1933 and Section 21E of the
Securities Exchange Act of 1934 that involve risks and uncertainties, such as
statements concerning:

. our growth and future operating results;

. the discovery and development of products;

. developments in our markets and strategic focus;

. new products;

. potential acquisitions and our integration of acquired businesses,
products and technologies;

. our strategic alliances;

. our intellectual property;

. our manufacturing, marketing, sales and distribution capabilities; and

. future economic, business and regulatory conditions.

We may, in some cases, use words such as "project," "believe," "anticipate,"
"plan," "expect," "estimate," "intend," "should," "would," "will," "could" or
"may," or other words that convey uncertainty of future events or outcomes to
identify forward-looking statements. There are a number of important factors
that could cause our actual results to differ materially from the results
indicated by the forward-looking statements that we include or incorporate by
reference in this prospectus. These important factors include, among others,
the factors that we identify and outline under "Risk Factors" in this
prospectus and in the documents we incorporate by reference in this prospectus.
You should read these factors and the other cautionary statements that we make
in this prospectus and in the documents we incorporate by reference as being
applicable to all related forward-looking statements that we make in this
prospectus and in the documents we incorporate by reference.

424B5 22nd Page of 60 TOC 1st Previous Next ↓Bottom Just 22nd
SELLING STOCKHOLDERS

The following table lists the selling stockholders and other information
regarding the beneficial ownership of the common stock by each of the selling
stockholders as of February 15, 2001. The information provided in the table
below has been obtained from the selling stockholders. The selling stockholders
may sell all, some or none of their shares in this offering. See "Plan of
Distribution."

The selling stockholders have represented to us that they purchased the
common stock for their own account for investment only and not with a view
toward selling or distributing the shares, except through sales registered
under the Securities Act or exemptions. We agreed with the selling stockholders
to file this registration statement to register the resale of the common stock.
We agreed to prepare and file all necessary amendments and supplements to the
registration statement to keep it effective until February 12, 2002.

The following table shows information, as of February 15, 2001, with respect
to the selling stockholders and the principal amounts of our common stock they
beneficially own and the number of shares that may be offered under this
prospectus. The information is based on information provided by or on behalf of
the selling stockholders.

The selling stockholders may offer all, some or none of the common stock.
Thus, we cannot estimate the amount of the common stock that will be held by
the selling stockholders upon termination of any sales. None of the selling
stockholders has had any material relationship with us or our affiliates within
the past three years, except as described below.

[Enlarge/Download Table]

Shares Owned
Shares Owned After Completion
Prior to Offering of the Offering(2)
------------------- Maximum -----------------
Name and Title of Selling Number of
Stockholder Number Percent(1) Shares Offered Number Percent(1)
----------- --------- ---------- -------------- ------ ----------

OrbiMed Advisors LLC(3)............ 2,473,117 7.3% 2,473,117 0 0%
767 Third Avenue, 6th Floor
New York, NY 10017
Oracle Strategic Partners, LP(4)... 2,150,000 6.4% 2,150,000 0 0%
712 5th Avenue, 45th Floor
New York, NY 10019
Larry Abrams....................... 35,055 * 35,055 0 0%
Charles J. Abronson................ 1,226 * 1,226 0 0%
John Aceti......................... 512 * 512 0 0%
Affymetrix, Inc.(5)................ 1,005,897 3.0% 1,005,897 0 0%
Alcyon Ltd......................... 504 * 504 0 0%
Robert Alpert...................... 981 * 981 0 0%
Steve Anderson(6).................. 35,155 * 25,636 9,519 *
AstraZeneca UK Limited(7).......... 222,980 * 222,980 0 0%
Banc One Capital Partners.......... 3,057 * 3,057 0 0%
Raymond L. Bank.................... 799 * 111 688 *
Leroy H. Barlow.................... 611 * 611 0 0%
Barracuda Invest AS................ 26,290 * 26,177 113 *
Frank Bennett...................... 351 * 351 0 0%
Francis Bonsal, Jr.(8)............. 53,051 * 53,051 0 *
Estate of Earl M. Brown............ 46,283 * 22,000 24,283 *
Keith Brown(9)..................... 275,234 * 236,966 38,268 *
Tamara Brown(10)................... 9,262 * 7,065 2,197 *
Richard Bryan...................... 51 * 51 0 0%
Beth Burnham TTEE Beth Burnham
Trust of 1993...................... 785 * 785 0 0%
Bruce Burnham TTEE Bruce Burnham
Trust of 1992...................... 785 * 785 0 0%

424B5 23rd Page of 60 TOC 1st Previous Next ↓Bottom Just 23rd
[Enlarge/Download Table]

Shares Owned
Shares Owned After Completion
Prior to Offering Maximum of the Offering(2)
------------------- Number of -------------------
Name and Title of Selling Stockholder Number Percent(1) Shares Offered Number Percent(1)
------------------------------------- --------- ---------- -------------- --------- ----------

Burrill AgBio Capital Fund, LP................ 444,444 1.3% 444,444 0 0%
J. Donald Capra............................... 17,198 * 17,198 0 0%
Catskill Company Ltd.......................... 2,452 * 2,452 0 0%
Webster K. Cavenee............................ 1,233 * 1,233 0 0%
George V. Charbonneau, Jr..................... 1,171 * 171 1,000 *
Chesterfield Associates....................... 40 * 40 0 0%
Andrew F. Clark............................... 213 * 213 0 0%
Peter Coyle................................... 730 * 730 0 0%
Timothy Davis................................. 1,825 * 1,825 0 0%
Geregory Deffley.............................. 351 * 351 0 0%
Robert R. Demers.............................. 2,733 2,733 0 0%
John Doskoczynski............................. 351 350 1 *
Durham Ressources Ltd......................... 330,658 1.0% 330,658 0 0%
EB Finance Co., Ltd.(11)...................... 877,667 * 775,000 102,667 *
Michael Ettenberg............................. 2,525 * 2,525 0 0%
Christine R. Filidoro(12)..................... 14,592 * 11,439 3,153 *
Fishers Island Partners....................... 11,111 * 11,111 0 0%
William Clay Ford Jr.......................... 2,466 * 2,466 0 0%
Walter Foxworth............................... 2,452 * 2,452 0 0%
Susan Gauff................................... 1,500 * 1,500 0 0%
Ann Devon Giacalone........................... 7,643 * 7,643 0 0%
John W. Glynn................................. 2,105 * 2,105 0 0%
Philip Goelet, Ph.D.(13)...................... 574,686 1.7% 569,639 5,047 *
Edward Gudusky................................ 368 * 368 0 0%
Mary Lou Hamilton............................. 245 * 245 0 0%
Sheila Hamp................................... 2,466 * 2,466 0 0%
The John A. Hartford Foundation............... 136,205 * 100,000 36,205 *
Jacob P. Hasili............................... 351 * 351 0 0%
Kay Roberts Hawthorne......................... 491 * 491 0 0%
Grace M. Hay.................................. 305 * 291 14 *
Jess Hay...................................... 491 * 491 0 0%
Wen Ho........................................ 1,054 * 1,054 0 0%
S. Roger Horchow.............................. 38,466 * 38,466 0 0%
Jasdec Partners............................... 1,570 * 1,570 0 0%
Grezegorg Kaganowicz(14)...................... 6,825 * 5,304 1,521 *
Tamara Kalmanovich............................ 351 * 351 0 0%
Kathleen D. Kinka............................. 182 * 6 176 *
Christina M. Knoedler......................... 310 * 210 100 *
Elizabeth F. Kontulis......................... 504 * 504 0 0%
Por Hsuing Lai(15)............................ 1,148,665 3.4% 133,332 1,015,333 3.4%
Prince Lal.................................... 379 * 379 0 0%
Aaron Levine.................................. 1,571 * 1,571 0 0%
Liniem S.A.................................... 133,334 * 133,334 0 0%
John Margican................................. 27 * 27 0 0%
Patricia C. Maske............................. 585 * 85 500 *
Evergreen Securities Inc. Cust. For William S.
McAffee IRA................................. 491 * 491 0 0%
Sterling E. McBride........................... 2,879 * 2,879 0 0%

424B5 24th Page of 60 TOC 1st Previous Next ↓Bottom Just 24th
[Enlarge/Download Table]

Shares Owned
Shares Owned After Completion
Prior to Offering Maximum of the Offering(2)
------------------- Number of -----------------
Name and Title of Selling Stockholder Number Percent(1) Shares Offered Number Percent(1)
------------------------------------- --------- ---------- -------------- ------- ----------

Doris R. McCallus................................ 117 * 17 100 *
Thomas C. McConnell.............................. 873 * 873 0 0%
Merifin Capital N.V.............................. 223,753 * 190,557 33,196 *
Leslie Priddy Moffitt............................ 613 * 613 0 0%
Joe Moran--401K.................................. 66,670 * 66,670 0 0%
Richard Moroney.................................. 7,279 * 2,277 5,002 *
Martha F. Morse.................................. 2,466 * 2,466 0 0%
National Academy of Science...................... 1,008 * 1,008 0 0%
NeoMed Innovation(16)............................ 300,263 * 292,763 7,500 *
Adair Newhall.................................... 62 * 62 0 0%
Amy Liebno Newhall............................... 62 * 62 0 0%
Ashton Newhall................................... 62 * 62 0 0%
Charles W. Newhall III........................... 5,712 * 5,712 0 0%
Kerry D. O'Mara.................................. 1,199 * 1,199 0 0%
Oxford Bioscience Partners(17)................... 522,492 1.6% 397,492 125,000 *
Ronald Pagodin................................... 351 * 351 0 0%
Paul F. Pelka.................................... 1,540 825 715 *
Dale R. Pfost, Ph.D.(18)......................... 337,502 1.0% 101,833 235,669 *
David Pfost...................................... 3,335 * 3,335 0 0%
Fred Pfost & JoAnn Pfost......................... 4,500 * 4,500 0 0%
President Life Sciences Cayman Co., Ltd.(19)..... 1,148,665 3.4% 1,000,000 148,665 *
Randy Priddy Irrevocable Trust................... 613 * 613 0 0%
Robert T. Priddy................................. 2,989 * 2,989 0 0%
Estate of Charles N. Prothro(20)................. 61,371 * 45,520 15,851 *
Joe N. Prothro(21)............................... 981 * 981 0 0%
Mark H. Prothro(22).............................. 736 * 736 0 0%
Dorsey B. Ray.................................... 245 * 245 0 0%
Rosalyn B. Ritts................................. 7,366 * 7,366 0 0%
Douglas C. Roberts Trust DTD 1/28/72............. 818 * 818 0 0%
J. Liston Roberts................................ 491 * 491 0 0%
Anne Robinson.................................... 351 * 351 0 0%
Rolling Stone LLC................................ 2,452 * 2,452 0 0%
Scherner Investments Limited..................... 334,200 1.0% 334,200 0 0%
Anton Schujko.................................... 905 * 905 0 0%
Walter P. Sjursen................................ 50 * 50 0 0%
SmithKline Beecham Corporation(23)............... 1,099,366 3.3% 575,103 524,263 1.6%
Paul J. Stabile.................................. 10,258 * 2,208 8,050 *
Margaret Mary Stroock............................ 491 * 491 0 0%
Josette Tatler................................... 368 * 368 0 0%
Anthony Tocci.................................... 27 * 27 0 0%
US Bank as CF Meyer Memorial Trust dtd 6/24/82... 4,032 * 4,032 0 0%
WPG-Farber(24)................................... 1,111,111 3.3% 1,111,111 0 0%
Norman Winarsky.................................. 3,775 * 3,775 0 0%
Woodwind Associates.............................. 2,452 * 2,452 0 0%

--------
* Less than one percent.
(1) Percentage of ownership prior to the offering is based on 33,443,293 shares
of common stock outstanding on February 15, 2001.

424B5 25th Page of 60 TOC 1st Previous Next ↓Bottom Just 25th
(2) Number of shares and percentage after completion of the offering assumes
that all of the shares held by the selling stockholders and being offered
under this prospectus are sold, that the shares are sold to unaffiliated
third parties and that the selling stockholders acquire no additional
shares of common stock before completion of this offering.
(3) Represents 807,749 shares of common stock held by Eaton Vance Worldwide
Health Sciences Fund, 100,000 shares of common stock subject to a
currently exercisable warrant held by Eaton Vance Worldwide Health
Sciences Fund, 410,254 shares of common stock held by Finsbury Worldwide
Pharmaceutical Trust, 100,000 shares of common stock subject to a
currently exercisable warrant held by Finsbury Worldwide Pharmaceutical
Trust, 526,782 shares of common stock held by PHARMAw/HEALTH, 75,000
shares of common stock subject to a currently exercisable warrant held by
PHARMAw/HEALTH, 74,074 shares of common stock held by Caduceus Capital II,
L.P., 148,148 shares held by Winchester Global Trust Company Limited as
Trustee For Caduceus Capital Trust, 222,222 shares of common stock held by
Hare & Co. for the benefit of Finsbury Worldwide Pharmaceutical Trust and
8,888 shares of common stock subject to a currently exercisable option
held by OrbiMed Advisors LLC. OrbiMed Advisors LLC is the investment
advisor for each of these funds, whose Managing Member, Samuel D. Isaly,
has sole authority to vote such shares. However, Mr. Isaly disclaims any
beneficial ownership in the shares of common stock held by the funds
managed by OrbiMed Advisors LLC, except to the extent of his pecuniary
interest in such shares, if any. Mr. Isaly serves as a member of our Board
of Directors.
(4) Larry Fineberg, who is a general partner of Oracle Strategic Partners, LP,
has the authority to vote such shares. However, Mr. Fineberg disclaims any
beneficial ownership in the shares of common stock held by Oracle
Strategic Partners, LP, except to the extent of his pecuniary interest in
such shares, if any.
(5) Includes 889 shares of common stock subject to currently exercisable
options, 800 shares held by Clara K. Anderson and 800 shares held by David
K. Anderson, Mr. Anderson's two minor children. Mr. Anderson serves as a
consultant on our Medical Advisory Board and our Scientific Advisory Board.
(6) We have entered into a collaboration agreement with Affymetrix for the
development and manufacturing of kits.
(7) We have entered into a SNP collaboration agreement with AstraZeneca for
genotyping services. In addition, in February 2001 we purchased our
Cellmark division from AstraZeneca.
(8) Prior to our acquisition of GeneScreen, Inc. in December 1999, Mr. Bonsal
served as a member of GeneScreen's Board of Directors.
(9) Includes 16,154 shares of common stock subject to currently exercisable
options. Mr. Brown also beneficially owns approximately half of the shares
held in the Estate of Earl M. Brown. Mr. Brown serves as Vice President of
our GeneScreen division, and prior to our acquisition of GeneScreen, Inc.
in December 1999, Mr. Brown also served as the GeneScreen's President and
Chairman of the Board of Directors.
(10) Includes 1,850 shares of common stock subject to currently exercisable
options. Ms. Brown is employed by GeneScreen, Inc., our wholly-owned
subsidiary.
(11) Includes 77,667 shares of common stock subject to a currently exercisable
warrant.
(12) Includes 2,592 shares of common stock subject to currently exercisable
options. Ms. Filidoro is an employee of GeneScreen, Inc., our wholly-owned
subsidiary.
(13) Includes 4,247 shares of common stock subject to currently exercisable
options. Mr. Goelet served on the Board of Directors of GeneScreen, Inc.
prior to our acquisition of the company in December 1999. Currently, Mr.
Goelet is a consultant who serves as a member of our Scientific Advisory
Board.
(14) Includes 521 shares of common stock subject to currently exercisable
options and 1,000 shares of common stock subject to currently exercisable
warrants.
(15) Includes 8,667 shares of common stock subject to a currently exercisable
warrant, 6,666 shares of common stock subject to a currently exercisable
option, 22,222 shares held by Chao Hsiung Hsu, 22,222 shares held by Chern
Hsiung Lai, 22,222 shares held by Tse Hsiung Lai, 22,222 shares held by
Yen Yueg Lai, 22,222 shares held by Yin Hsiung Lai and 1,000,000 shares
held by President Life Sciences Cayman

424B5 26th Page of 60 TOC 1st Previous Next ↓Bottom Just 26th
Co., Ltd. Dr. Lai has authority to vote such shares. However, Dr. Lai
disclaims any beneficial ownership in the shares of common stock held by
Chao Hsiung Hsu, Chern Hsiung Lai, Tse Hsiung Lai, Yen Yueng Lai, Yin
Hsiung Lai and President Life Sciences Cayman Co., Ltd., except to the
extent of his pecuniary interest in such shares if any. Dr. Lai serves as a
consultant regarding our business opportunities in the greater China
region. Please also see footnote #19.
(16) Includes 7,500 shares of common stock subject to currently exercisable
warrants.
(17) Includes 109,076 shares of common stock held by Oxford Bioscience Partners
(Bermuda) II Limited Partnership, 34,302 shares of common stock subject to
warrants currently exercisable by Oxford Bioscience Partners (Bermuda) II
Limited Partnership, 142,862 shares of common stock held by Oxford
Bioscience Partners (GS adjunct) II Limited Partnership, 44,926 shares of
common stock subject to warrants currently exercisable by Oxford
Bioscience Partners (GS adjunct) II Limited Partnership, 145,554 shares of
common stock held by Oxford Bioscience Partners II, L.P. and 45,772 shares
of common stock subject to warrants currently exercisable by Oxford
Bioscience Partners II, L.P. Dr. Alan G. Walton, the general partner of
each of these funds, has sole authonrity to vote such shares. However,
Dr. Walton disclaims any beneficial ownership in the shares of common
stock held by Oxford Biosciences Partners, except to the extent of his
pecuniary interest in such shares, if any.
(18) Includes 225,111 shares of common stock subject to currently exercisable
options, 2,500 shares held by Dr. Pfost's wife individually, and 2,500
shares held jointly by Dr. Pfost's wife and minor son.
(19) Includes 8,667 shares of common stock subject to a warrant currently
exercisable by Dr. Lai, 6,666 shares of common stock subject to an option
currently exercisable by Dr. Lai, 22,222 shares of common stock held by
Dr. Lai, 22,222 shares held by Chao Hsiung Hsu, 22,222 shares held by
Chern Hsiung Lai, 22,222 shares held by Tse Hsiung Lai, 22,222 shares held
by Yen Yueng Lai and 22,222 shares held by Yin Hsiung Lai. Dr. Lai has the
authority to vote these shares. Dr. Lai is the President of the President
Life Sciences Cayman Co., Ltd. and has sole authority to vote such shares.
However, Dr. Lai disclaims any beneficial ownership in the shares of
common stock held by President Life Sciences Cayman Co., Ltd. Chao Hsuing
Hsu, Chern Hsiung Lai, Tse Hsiung Lai, Yen Yeung Lai and Yin Hsiung Lai,
except to the extent of his pecuniary interest in such shares, if any. Dr.
Lai serves as a consultant regarding our business opportunities in the
greater China region. Please also see footnote #15.
(20) Mark H. Prothro and Joe N. Prothro are the co-executors of the Estate of
Charles N. Prothro and as such have the authority to vote such shares.
(21) Does not include shares held by the Estate of Charles N. Prothro. Mr.
Prothro is the co-executor of the estate.
(22) Does not include shares held by the Estate of Charles N. Prothro. Mr.
Prothro is the co-executor of the estate.
(23) Includes 138,000 shares of common stock subject to a currently exercisable
warrant and 438,183 shares of common stock held by SmithKline Beecham plc.
We have entered into a license agreement and a service agreement with
SmithKline Beecham related to our SNPstream technology.
(24) Represents 916,627 shares of common stock held by WPG-Farber, Present
Fund, L.P., 106,542 shares of common stock held by WPG-Farber, Present QP
Fund, L.P., 31,676 shares of common stock held by WPG-Farber, Present
Institutional Fund, L.P. and 56,266 shares of common stock held by
WPG-Farber, Present Overseas Fund, L.P. Michael E. Singer is the General
Counsel and Managing Director of each of these funds, and has authority to
vote such shares.

USE OF PROCEEDS

Unless indicated otherwise in the applicable prospectus supplement, we
intend to use the net proceeds from this offering for general corporate
purposes, including our internal discovery and development programs and the
development of new technologies, general working capital and possible future
acquisitions.

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We have not determined the amounts we plan to spend on any of the areas
listed above or the timing of these expenditures. As a result, our management
will have broad discretion to allocate the net proceeds from this offering.
Pending application of the net proceeds as described above, we intend to invest
the net proceeds of the offering in short-term, investment-grade,
interest-bearing securities.

We will not receive proceeds from any sale of common stock by selling
stockholders.

RATIO OF EARNINGS TO FIXED CHARGES

Earnings were insufficient to cover fixed charges by approximately the
following amounts for the years ended as set forth below:

[Download Table]

Year ended December 31,
-------------------------------------
(in thousands)
2000 1999 1998 1997 1996
------- ------- ------- ------ ------

Deficiency of earnings to cover
charges........................... $47,867 $28,220 $11,479 $9,928 $1,124

"Fixed charges" consists of:

. interest expense plus the portion of rent expense under operating leases
deemed by us to be representative of the interest factor, and

. amoritization of debt issuance costs.

THE SECURITIES WE MAY OFFER

The descriptions of the securities contained in this prospectus, together
with the applicable prospectus supplements, summarize all the material terms
and provisions of the various types of securities that we may offer. We will
describe in the applicable prospectus supplement relating to any securities the
particular terms of the securities offered by that prospectus supplement. If we
indicate in the applicable prospectus supplement, the terms of the securities
may differ from the terms we have summarized below. We will also include in the
prospectus supplement information, where applicable, about material United
States federal income tax considerations relating to the securities, and the
securities exchange, if any, on which the securities will be listed.

DESCRIPTION OF CAPITAL STOCK

The following description of our capital stock and certain provisions of our
certificate of incorporation and by-laws is a summary and are qualified in its
entirety by the provisions of our certificate of incorporation and by-laws.

Our authorized capital stock consists of 100,000,000 shares of common stock,
par value of $.001 per share, and 5,000,000 shares of preferred stock, par
value of $.001 per share.

Common Stock

Holders of our common stock are entitled to one vote for each share held of
record on all matters submitted to a vote of stockholders and do not have
cumulative voting rights. Accordingly, holders of a majority of the shares of
common stock entitled to vote in any election of directors may elect all of the
directors standing for election. Holders of common stock have no preemptive,
subscription, redemption or conversion rights and are not subject to future
calls or assessments by us. No sinking fund provisions apply to our common
stock. All outstanding shares are fully-paid and non-assessable. In the event
of our liquidation, dissolution or winding up, holders of common stock are
entitled to share ratably in assets available for distribution, subject to prior

424B5 28th Page of 60 TOC 1st Previous Next ↓Bottom Just 28th
distribution rights of preferred stock, if any, then outstanding. Holders of
common stock are entitled to receive proportionately any such dividends
declared by the board of directors, out of legally available funds for the
dividends subject to the rights of the holders of our preferred stock and any
preferences that may be applicable to any other then outstanding preferred
stock. See "Shares Eligible for Future Sale."

Preferred Stock

Our Board of Directors is authorized to issue up to 5,000,000 shares of
preferred stock in one or more series without stockholder approval. Our Board
of Directors also has discretion to determine the rights, preferences,
privileges and restrictions, including voting rights, dividend rights,
conversion rights, redemption privileges and liquidation preferences of each
series of preferred stock.

The purpose of authorizing our Board of Directors to issue preferred stock
in one or more series and determine the number of shares in the series and its
rights and preferences is to eliminate delays associated with a stockholder
vote on specific issuances. Examples of rights and preferences that the Board
of Directors may fix are (1) dividend rights, (2) dividend rates, (3)
conversion rights, (4) voting rights, (5) terms of redemption, including
sinking price or prices, and (6) liquidation preferences. The issuance of
preferred stock, while providing desirable flexibility in connection with
possible acquisitions and other corporate purposes, could make it more
difficult for a third party to acquire, or could discourage a third party from
acquiring, a majority of our outstanding voting stock. The rights of holders of
our common stock described above, including economic rights, will be subject
to, and may be adversely affected by, the rights of any preferred stock that we
may designated and issue in the future.

We will incorporate by reference as an exhibit to the registration statement
which includes this prospectus the form of any certificate of designation which
describes the terms of the series of preferred stock we are offering before the
issuance of the related series of preferred stock. This description will
include:

. the title and stated value;

. the number of shares we are offering;

. the liquidation preference per share;

. the purchase price;

. the dividend rate, period and payment date, and method of calculation for
dividends;

. whether dividends will be cumulative or non-cumulative and, if cumulative,
the date from which dividends will accumulate;

. the procedures for any auction and remarketing, if any;

. the provisions for a sinking fund, if any;

. the provisions for redemption or repurchase, if applicable, and any
restrictions on our ability to exercise those redemption and repurchase
rights;

. any listing of the preferred stock on any securities exchange or market;

. whether the preferred stock will be convertible into our common stock,
and, if applicable, the conversion price, or how it will be calculated,
and the conversion period;

. whether the preferred stock will be exchangeable into debt securities,
and, if applicable, the exchange price, or how it will be calculated, and
the exchange period;

. voting rights, if any, of the preferred stock;

. preemption rights, if any;

. restrictions on transfer, sale or other assignment, if any;

. whether interests in the preferred stock will be represented by depositary
shares;

424B5 29th Page of 60 TOC 1st Previous Next ↓Bottom Just 29th
. a discussion of any material or special United States federal income tax
considerations applicable to the preferred stock;

. the relative ranking and preferences of the preferred stock as to dividend
rights and rights if we liquidate, dissolve or wind up our affairs;

. any limitations on issuance of any class or series of preferred stock
ranking senior to or on a parity with the series of preferred stock as to
dividend rights and rights if we liquidate, dissolve or wind up our
affairs; and

. any other specific terms, preferences, rights or limitations of, or
restrictions on, the preferred stock.

When we issue share of preferred stock under this prospectus, the shares
will fully be paid and nonassessable and will not have, or be subject to, any
preemptive or similar rights.

The General Corporation Law of Delaware provides that the holders of
preferred stock will have the right to vote separately as a class on any
proposal involving fundamental changes in the rights of holders of that
preferred stock. This right is in addition to any voting rights that may be
provided for in the applicable certificate of designation.

Warrants

As of December 31, 2001, there were outstanding warrants to purchase
1,744,557 shares of common stock held by 33 investors. Such warrants have a
weighted average exercise price of $4.66 per share. The number of shares for
which the warrants are exercisable is subject to adjustment for stock splits,
combinations or dividends and reclassifications, exchanges or substitutions.

Registration Rights

As of December 31, 2001, the holders of approximately 24,713,001 shares of
common stock, of which 12,765,535 are registered pursuant to this registration
statement, are entitled to rights with respect to the registration of those
shares under the Securities Act of 1933 as follows:

Demand Registration Rights. Under the terms of the agreements between us
and the holders of those registrable shares, the former holders of Series A
convertible preferred stock, the former holders of Series B convertible
preferred stock and the holders of not less than one-third of the former
holders of Series C convertible preferred stock and Series E convertible
preferred stock may at any time require us to file a registration statement
under the Securities Act with respect to shares of common stock owned by them
and we are required to use our reasonable best efforts to effect that
registration.

Piggyback Registration Rights. Also, if we propose to register any of our
securities under the Securities Act, other than in connection with demand
registrations, registrations on Form S-8 or in connection with our public
offering, the foregoing holders are entitled to notice of and to include in the
registration shares of common stock owned by them.

S-3 Registration Rights. Finally, the former holders of not less than 25%
of the Series C convertible preferred stock and Series E convertible preferred
stock and a certain holder of common stock may require us to file a
registration statement under the Securities Act on Form S-3 with respect to
shares of common stock owned by them.

All of these registration rights are subject to various conditions and
limitations, among them certain rights of the underwriters of an offering to
limit the number of shares included in a registration and our right not to
effect a requested registration within 90 days after the effective date of a
previous registration on a Form S-1 or within 90 days after the effective date
of a registration which included all shares requested by holders of registrable
shares. We will bear all of the expenses incurred in connection with all
exercises of these registration rights.

In addition, in connection with our acquisition of Lifecodes Corporation in
December 2001, we agreed to prepare and file a registration statement under the
Securities Act on Form S-3 by April 4, 2002 with respect to 3,035,040 shares of
common stock we issued in connection with the acquisition to those stockholders
of Lifecodes who were affiliates of Lifecodes as of the date of the special
meeting of Lifecodes' stockholders held to approve the acquisition. We must use
reasonable commercial efforts to cause the registration statement to become
effective by June 3, 2002 and use our best efforts to maintain the
effectiveness of the registration statement until the earlier of such time as
(a) the affiliate stockholders may sell all of the shares registered under the
registration statement under

424B5 30th Page of 60 TOC 1st Previous Next ↓Bottom Just 30th
Rule 144(k) or Rule 145 promulgated under the Securities Act, or (b) all of the
shares registered under the registration statement have been sold by the
affiliate stockholders.

Delaware Law and Certain Charter and By-Law Provisions

We are subject to the provisions of Section 203 of the Delaware General
Corporation Law statute. Section 203 prohibits a publicly held Delaware
corporation from engaging in a business combination with an interested
stockholder for a period of three years after the person becomes an interested
stockholder, unless the business combination is approved in a prescribed
manner. A business combination includes mergers, asset sales and other
transactions resulting in a financial benefit to the interested stockholder.
Subject to certain exceptions, an interested stockholder is a person who,
together with affiliates and associates, owns, or within three years did own,
15% or more of the corporation's voting stock.

Our by-laws divide the Board of Directors into three classes with staggered
three-year terms. Under the by-laws, any vacancy on our Board of Directors,
including a vacancy resulting from an enlargement of our Board of Directors,
may only be filled by vote of a majority of the directors then in office. The
classification of the Board of Directors and the limitation on filling of
vacancies could make it more difficult for a third party to acquire, or
discourage a third party from acquiring, control of our company.

Our by-laws also provide that stockholders can only take action at an annual
meeting or special meeting, and not by written action in lieu of a meeting. Our
by-laws further provide that only stockholders holding a majority of
outstanding shares, our Chairman of the Board, President or our Board of
Directors may call a special meeting of stockholders.

Our stockholders must comply with advance notice and information disclosure
requirements in order for any matter to be considered "properly brought" before
a meeting. Stockholders must deliver written notice to us between 60 and 90
days prior to the meeting. If we give less than 70 days' notice or prior public
disclosure of the meeting date, stockholders must deliver written notice to us
within ten days following the date upon which the notice of the meeting was
mailed or such public disclosure was made, whichever occurs first. If the
matter relates to the election of directors, the notice must set forth specific
information regarding each nominee and the nominating stockholder. For any
other matter, the notice must set forth a brief description of the proposed
matter and certain information regarding the proponent stockholder. These
provisions could delay until the next stockholders' meeting proposed actions
which are favored by the holders of a majority of our outstanding voting
securities. These provisions could also discourage a third party from making a
tender offer for our common stock, because even if it acquired a majority of
the outstanding voting securities, the third party would be able to take action
as a stockholder only at a duly called stockholders' meeting, and not by
written consent.

The Delaware General Corporation Law statute provides generally that the
affirmative vote of a majority of the shares entitled to vote on any matter is
required to amend a corporation's certificate of incorporation or by-laws,
unless a corporation's certificate of incorporation or by-laws, as the case may
be, requires a greater percentage. Our by-laws require the affirmative vote of
holders of at least 70% of the votes which all the stockholders would be
entitled to cast in any annual election of directors or class of directors to
amend or repeal any of the provisions described in the prior two paragraphs.

Our certificate of incorporation contains certain provisions permitted under
the Delaware General Corporation Law statute relating to the limitation of
liability of directors. These provisions eliminate a director's liability for
monetary damages for a breach of fiduciary duty, except in certain
circumstances involving wrongful acts, such as the breach of a director's duty
of loyalty or acts or omissions which involve intentional misconduct or a
knowing violation of law. Further, the certificate of incorporation contains
provisions to indemnify our directors and officers to the fullest extent
permitted by the Delaware General Corporation Law statute. We believe these
provisions will assist us in attracting and retaining qualified individuals to
serve as our directors.

Transfer Agent and Registrar

The transfer agent and registrar for our common stock is American Stock
Transfer & Trust Company.

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DESCRIPTION OF DEBT SECURITIES

The following description, together with the additional information we
include in any applicable prospectus supplements, summarizes the material terms
and provisions of the debt securities that we may offer under this prospectus.
While the terms we have summarized below will apply generally to any future
debt securities we may offer, we will describe the particular terms of any debt
securities that we may offer in more detail in the applicable prospectus
supplement. If we indicate in a prospectus supplement, the terms of any debt
securities we offer under that prospectus supplement may differ from the terms
we describe below.

We will issue the senior notes under the senior indenture which we will
enter into with a trustee to be named in the senior indenture. We will issue
the subordinated notes under the subordinated indenture which we will enter
into with a trustee to be named in the subordinated indenture. We have filed
forms of these documents as exhibits to the registration statement which
includes this prospectus. We use the term "indentures" to refer to both the
senior indenture and the subordinated indenture. The indentures will be
qualified under the Trust Indenture Act. We use the term "debenture trustee" to
refer to either the senior trustee or the subordinated trustee, as applicable.

The following summaries of material provisions of the senior notes, the
subordinated notes and the indentures are subject to, and qualified in their
entirety by reference to, all the provisions of the indenture applicable to a
particular series of debt securities. Except as we may otherwise indicate, the
terms of the senior indenture and the subordinated indenture are identical.

We conduct some of our operations through our subsidiaries. Our rights and
the rights of our creditors, including holders of debt securities, to the
assets of any subsidiary of ours upon that subsidiary's liquidation or
reorganization or otherwise would be subject to the prior claims of that
subsidiary's creditors, except to the extent that we may be a creditor with
recognized claims against the subsidiary. Our subsidiaries' creditors would
include trade creditors, debt holders, secured creditors and taxing
authorities. Except as we may provide in a prospectus supplement, neither the
debt securities nor the indentures restrict us or any of our subsidiaries from
incurring indebtedness.

General

We will describe in each prospectus supplement the following terms relating
to a series of notes:

. the title;

. any limit on the amount that may be issued;

. whether or not we will issue the series of notes in global form, the terms
and who the depository will be;

. the maturity date;

. the annual interest rate, which may be fixed or variable, or the method
for determining the rate and the date interest will begin to accrue, the
dates interest will be payable and the regular record dates for interest
payment dates or the method for determining such dates;

. whether or not the notes will be secured or unsecured, and the terms of
any secured debt;

. the terms of the subordination of any series of subordinated debt;

. the place where payments will be payable;

. our right, if any, to defer payment of interest and the maximum length of
any such deferral period;

. the date, if any, after which, and the price at which, we may, at our
option, redeem the series of notes pursuant to any optional redemption
provisions;

. the date, if any, on which, and the price at which we are obligated,
pursuant to any mandatory sinking fund provisions or otherwise, to redeem,
or at the holder's option to purchase, the series of notes;

. whether the indenture will restrict our ability to pay dividends, or will
require us to maintain any asset ratios or reserves;

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. whether we will be restricted from incurring any additional indebtedness;

. a discussion on any material or special United States federal income tax
considerations applicable to the notes;

. the denominations in which we will issue the series of notes, if other
than denominations of $1,000 and any integral multiple thereof; and

. any other specific terms, preferences, rights or limitations of, or
restrictions on, the debt securities.

Conversion or Exchange Rights

We will set forth in the prospectus supplement the terms on which a series
of notes may be convertible into or exchangeable for common stock or other
securities of ours. We will include provisions as to whether conversion or
exchange is mandatory, at the option of the holder or at our option. We may
include provisions pursuant to which the number of shares of common stock or
other securities of ours that the holders of the series of notes receive would
be subject to adjustment.

Consolidation, Merger or Sale

The indentures do not contain any covenant which restricts our ability to
merge or consolidate, or sell, convey, transfer or otherwise dispose of all or
substantially all of our assets. However, any successor to or acquirer of such
assets must assume all of our obligations under the indentures or the notes, as
appropriate.

Events of Default Under the Indenture

The following are events of default under the indentures with respect to any
series of notes that we may issue:

. if we fail to pay interest when due and our failure continues for 90 days
and the time for payment has not been extended or deferred;

. if we fail to pay the principal, or premium, if any, when due and the time
for payment has not been extended or delayed;

. if we fail to observe or perform any other covenant contained in the notes
or the indentures, other than a covenant specifically relating to another
series of notes, and our failure continues for 90 days after we receive
notice from the debenture trustee or holders of at least 25% in aggregate
principal amount of the outstanding notes of the applicable series; and

. if specified events of bankruptcy, insolvency or reorganization occur as
to us.

If an event of default with respect to notes of any series occurs and is
continuing, the debenture trustee or the holders of at least 25% in aggregate
principal amount of the outstanding notes of that series, by notice to us in
writing, and to the debenture trustee if notice is given by such holders, may
declare the unpaid principal of, premium, if any, and accrued interest, if any,
due and payable immediately.

The holders of a majority in principal amount of the outstanding notes of an
affected series may waive any default or event of default with respect to the
series and its consequences, except defaults or events of default regarding
payment of principal, premium, if any, or interest, unless we have cured the
default or event of default in accordance with the indenture. Any waiver shall
cure the default or event of default.

Subject to the terms of the indentures, if an event of default under an
indenture shall occur and be continuing, the debenture trustee will be under no
obligation to exercise any of its rights or powers under such indenture at the
request or direction of any of the holders of the applicable series of notes,
unless such holders have offered the debenture trustee reasonable indemnity.
The holders of a majority in principal amount of the outstanding notes of any
series will have the right to direct the time, method and place of conducting
any

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proceeding for any remedy available to the debenture trustee, or exercising any
trust or power conferred on the debenture trustee, with respect to the notes of
that series, provided that:

. the direction so given by the holder is not in conflict with any law or
the applicable indenture; and

. subject to its duties under the Trust Indenture Act, the debenture trustee
need not take any action that might involve it in personal liability or
might be unduly prejudicial to the holders not involved in the proceeding.

. a holder of the notes of any series will only have the right to institute
a proceeding under the indentures or to appoint a receiver or trustee, or
to seek other remedies if:

. the holder has given written notice to the debenture trustee of a
continuing event of default with respect to that series;

. the holders of at least 25% in aggregate principal amount of the
outstanding notes of that series have made written request, and such
holders have offered reasonable indemnity to the debenture trustee to
institute the proceeding as trustee; and

. the debenture trustee does not institute the proceeding, and does not
receive from the holders of a majority in aggregate principal amount of
the outstanding notes of that series other conflicting directions within
60 days after the notice, request and offer.

These limitations do not apply to a suit instituted by a holder of notes if
we default in the payment of the principal, premium, if any, or interest on,
the notes.

We will periodically file statements with the debenture trustee regarding
our compliance with specified covenants in the indentures.

Modification of Indenture; Waiver

We and the debenture trustee may change an indenture without the consent of
any holders with respect to specific matters, including:

. to fix any ambiguity, defect or inconsistency in the indenture; and

. to change anything that does not materially adversely affect the interests
of any holder of notes of any series.

In addition, under the indentures, the rights of holders of a series of
notes may be changed by us and the debenture trustee with the written consent
of the holders of at least a majority in aggregate principal amount of the
outstanding notes of each series that is affected. However, we and the
debenture trustee may only make the following changes with the consent of each
holder of any outstanding notes affected:

. extending the fixed maturity of the series of notes;

. reducing the principal amount, reducing the rate of or extending the time
of payment of interest, or any premium payable upon the redemption of any
notes; or

. reducing the percentage of notes, the holders of which are required to
consent to any amendment.

Discharge

Each indenture provides that we can elect to be discharged from our
obligations with respect to one or more series of debt securities, except for
obligations to:

. register the transfer or exchange of debt securities of the series;

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. replace stolen, lost or mutilated debt securities of the series;

. maintain paying agencies;

. hold monies for payment in trust;

. compensate and indemnify the trustee; and

. appoint any successor trustee.

In order to exercise our rights to be discharged, we must deposit with the
trustee money or government obligations sufficient to pay all the principal of,
any premium, if any, and interest on, the debt securities of the series on the
dates payments are due.

Form, Exchange, and Transfer

We will issue the notes of each series only in fully registered form without
coupons and, unless we otherwise specify in the applicable prospectus
supplement, in denominations of $1,000 and any integral multiple thereof. The
indentures provide that we may issue notes of a series in temporary or
permanent global form and as book-entry securities that will be deposited with,
or on behalf of, The Depository Trust Company or another depository named by us
and identified in a prospectus supplement with respect to that series. See
"Legal Ownership of Securities" for a further description of the terms relating
to any book-entry securities.

At the option of the holder, subject to the terms of the indentures and the
limitations applicable to global securities described in the applicable
prospectus supplement, the holder of the notes of any series can exchange the
notes for other notes of the same series, in any authorized denomination and of
like tenor and aggregate principal amount.

Subject to the terms of the indentures and the limitations applicable to
global securities set forth in the applicable prospectus supplement, holders of
the notes may present the notes for exchange or for registration of transfer,
duly endorsed or with the form of transfer endorsed thereon duly executed if so
required by us or the security registrar, at the office of the security
registrar or at the office of any transfer agent designated by us for this
purpose. Unless otherwise provided in the notes that the holder presents for
transfer or exchange, we will make no service charge for any registration of
transfer or exchange, but we may require payment of any taxes or other
governmental charges.

We will name in the applicable prospectus supplement the security registrar,
and any transfer agent in addition to the security registrar, that we initially
designate for any notes. We may at any time designate additional transfer
agents or rescind the designation of any transfer agent or approve a change in
the office through which any transfer agent acts, except that we will be
required to maintain a transfer agent in each place of payment for the notes of
each series.

If we elect to redeem the notes of any series, we will not be required to:

. issue, register the transfer of, or exchange any notes of that series
during a period beginning at the opening of business 15 days before the
day of mailing of a notice of redemption of any notes that may be selected
for redemption and ending at the close of business on the day of the
mailing; or

. register the transfer of or exchange any notes so selected for redemption,
in whole or in part, except the unredeemed portion of any notes we are
redeeming in part.

Information Concerning the Debenture Trustee

The debenture trustee, other than during the occurrence and continuance of
an event of default under an indenture, undertakes to perform only those duties
as are specifically set forth in the applicable indenture. Upon an event of
default under an indenture, the debenture trustee must use the same degree of
care as a prudent

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person would exercise or use in the conduct of his or her own affairs. Subject
to this provision, the debenture trustee is under no obligation to exercise any
of the powers given it by the indentures at the request of any holder of notes
unless it is offered reasonable security and indemnity against the costs,
expenses and liabilities that it might incur.

Payment and Paying Agents

Unless we otherwise indicate in the applicable prospectus supplement, we
will make payment of the interest on any notes on any interest payment date to
the person in whose name the notes, or one or more predecessor securities, are
registered at the close of business on the regular record date for the interest.

We will pay principal of and any premium and interest on the notes of a
particular series at the office of the paying agents designated by us, except
that unless we otherwise indicate in the applicable prospectus supplement, will
we make interest payments by check which we will mail to the holder. Unless we
otherwise indicate in a prospectus supplement, we will designate the corporate
trust office of the debenture trustee in the City of New York as our sole
paying agent for payments with respect to notes of each series. We will name in
the applicable prospectus supplement any other paying agents that we initially
designate for the notes of a particular series. We will maintain a paying agent
in each place of payment for the notes of a particular series.

All money we pay to a paying agent or the debenture trustee for the payment
of the principal of or any premium or interest on any notes which remains
unclaimed at the end of two years after such principal, premium or interest has
become due and payable will be repaid to us, and the holder of the security
thereafter may look only to us for payment thereof.

Governing Law

The indentures and the notes will be governed by and construed in accordance
with the laws of the State of Delaware, except to the extent that the Trust
Indenture Act is applicable.

Subordination of Subordinated Notes

The subordinated notes will be unsecured and will be subordinate and junior
in priority of payment to certain of our other indebtedness to the extent
described in a prospectus supplement. The subordinated indenture does not limit
the amount of subordinated notes which we may issue. It also does not limit us
from issuing any other secured or unsecured debt.

DESCRIPTION OF WARRANTS

The following description, together with the additional information we may
include in any applicable prospectus supplements, summarizes the material terms
and provisions of the warrants that we may offer under this prospectus and the
related warrant agreements and warrant certificates. While the terms summarized
below will apply generally to any warrants that we may offer, we will describe
the particular terms of any series of warrants in more detail in the applicable
prospectus supplement. If we indicate in the prospectus supplement, the terms
of any warrants offered under that prospectus supplement may differ from the
terms described below. Specific warrant agreements will contain additional
important terms and provisions and will be incorporated by reference as an
exhibit to the registration statement which includes this prospectus.

General

We may issue warrants for the purchase of common stock, preferred stock
and/or debt securities in one or more series. We may issue warrants
independently or together with common stock, preferred stock and/or debt
securities, and the warrants may be attached to or separate from these
securities.

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We will evidence each series of warrants by warrant certificates that we
will issue under a separate agreement. We will enter into the warrant agreement
with a warrant agent. Each warrant agent will be a bank that we select which
has its principal office in the United States and a combined capital and
surplus of at least $50,000,000. We will indicate the name and address of the
warrant agent in the applicable prospectus supplement relating to a particular
series of warrants.

We will describe in the applicable prospectus supplement the terms of the
series of warrants, including:

. the offering price and aggregate number of warrants offered;

. the currency for which the warrants may be purchased;

. if applicable, the designation and terms of the securities with which the
warrants are issued and the number of warrants issued with each such
security or each principal amount of such security;

. if applicable, the date on and after which the warrants and the related
securities will be separately transferable;

. in the case of warrants to purchase debt securities, the principal amount
of debt securities purchasable upon exercise of one warrant and the price
at, and currency in which, this principal amount of debt securities may be
purchased upon such exercise;

. in the case of warrants to purchase common stock or preferred stock, the
number of shares of common stock or preferred stock, as the case may be,
purchasable upon the exercise of one warrant and the price at which these
shares may be purchased upon such exercise;

. the effect of any merger, consolidation, sale or other disposition of our
business on the warrant agreement and the warrants;

. the terms of any rights to redeem or call the warrants;

. any provisions for changes to or adjustments in the exercise price or
number of securities issuable upon exercise of the warrants;

. the dates on which the right to exercise the warrants will commence and
expire;

. the manner in which the warrant agreement and warrants may be modified;

. federal income tax consequences of holding or exercising the warrants;

. the terms of the securities issuable upon exercise of the warrants; and

. any other specific terms, preferences, rights or limitations of or
restrictions on the warrants.

Before exercising their warrants, holders of warrants will not have any of
the rights of holders of the securities purchasable upon such exercise,
including:

. in the case of warrants to purchase debt securities, the right to receive
payments of principal of, or premium, if any, or interest on, the debt
securities purchasable upon exercise or to enforce covenants in the
applicable indenture; or

. in the case of warrants to purchase common stock or preferred stock, the
right to receive dividends, if any, or, payments upon our liquidation,
dissolution or winding up or to exercise voting rights, if any.

Exercise of Warrants

Each warrant will entitle the holder to purchase the securities that we
specify in the applicable prospectus supplement at the exercise price that we
describe in the applicable prospectus supplement. Unless we otherwise specify
in the applicable prospectus supplement, holders of the warrants may exercise
the warrants at any time up to 5:00 P.M. Boston, Massachusetts time on the
expiration date that we set forth in the applicable prospectus supplement.
After the close of business on the expiration date, unexercised warrants will
become void.

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Holders of the warrants may exercise the warrants by delivering the warrant
certificate representing the warrants to be exercised together with specified
information, and paying the required amount to the warrant agent in immediately
available funds, as provided in the applicable prospectus supplement. We will
set forth on the reverse side of the warrant certificate and in the applicable
prospectus supplement the information that the holder of the warrant will be
required to deliver to the warrant agent.

Upon receipt of the required payment and the warrant certificate properly
completed and duly executed at the corporate trust office of the warrant agent
or any other office indicated in the applicable prospectus supplement, we will
issue and deliver the securities purchasable upon such exercise. If fewer than
all of the warrants represented by the warrant certificate are exercised, then
we will issue a new warrant certificate for the remaining amount of warrants.
If we so indicate in the applicable prospectus supplement, holders of the
warrants may surrender securities as all or part of the exercise price for
warrants.

Enforceability of Rights By Holders of Warrants

Each warrant agent will act solely as our agent under the applicable warrant
agreement and will not assume any obligation or relationship of agency or trust
with any holder of any warrant. A single bank or trust company may act as
warrant agent for more than one issue of warrants. A warrant agent will have no
duty or responsibility in case of any default by us under the applicable
warrant agreement or warrant, including any duty or responsibility to initiate
any proceedings at law or otherwise, or to make any demand upon us. Any holder
of a warrant may, without the consent of the related warrant agent or the
holder of any other warrant, enforce by appropriate legal action its right to
exercise, and receive the securities purchasable upon exercise of, its warrants.

LEGAL OWNERSHIP OF SECURITIES

We can issue securities in registered form or in the form of one or more
global securities. We describe global securities in greater detail below. We
refer to those persons who have securities registered in their own names on the
books that we or any applicable trustee maintain for this purpose as the
"holders" of those securities. These persons are the legal holders of the
securities. We refer to those persons who, indirectly through others, own
beneficial interests in securities that are not registered in their own names,
as "indirect holders" of those securities. As we discuss below, indirect
holders are not legal holders, and investors in securities issued in book-entry
form or in street name will be indirect holders.

Book-Entry Holders

We may issue securities in book-entry form only, as we will specify in the
applicable prospectus supplement. This means securities may be represented by
one or more global securities registered in the name of a financial institution
that holds them as depositary on behalf of other financial institutions that
participate in the depositary's book-entry system. These participating
institutions, which are referred to as participants, in turn, hold beneficial
interests in the securities on behalf of themselves or their customers.

Only the person in whose name a security is registered is recognized as the
holder of that security. Securities issued in global form will be registered in
the name of the depositary or its participants. Consequently, for securities
issued in global form, we will recognize only the depositary as the holder of
the securities, and we will make all payments on the securities to the
depositary. The depositary passes along the payments it receives to its
participants, which in turn pass the payments along to their customers who are
the beneficial owners. The depositary and its participants do so under
agreements they have made with one another or with their customers; they are
not obligated to do so under the terms of the securities.

As a result, investors in a book-entry security will not own securities
directly. Instead, they will own beneficial interests in a global security,
through a bank, broker or other financial institution that participates in

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the depositary's book-entry system or holds an interest through a participant.
As long as the securities are issued in global form, investors will be indirect
holders, and not holders, of the securities.

Street Name Holders

We may terminate a global security or issue securities in non-global form.
In these cases, investors may choose to hold their securities in their own
names or in "street name." Securities held by an investor in street name would
be registered in the name of a bank, broker or other financial institution that
the investor chooses, and the investor would hold only a beneficial interest in
those securities through an account he or she maintains at that institution.

For securities held in street name, we will recognize only the intermediary
banks, brokers and other financial institutions in whose names the securities
are registered as the holders of those securities, and we will make all
payments on those securities to them. These institutions pass along the
payments they receive to their customers who are the beneficial owners, but
only because they agree to do so in their customer agreements or because they
are legally required to do so. Investors who hold securities in street name
will be indirect holders, not holders, of those securities.

Legal Holders

Our obligations, as well as the obligations of any applicable trustee and of
any third parties employed by us or a trustee, run only to the legal holders of
the securities. We do not have obligations to investors who hold beneficial
interests in global securities, in street name or by any other indirect means.
This will be the case whether an investor chooses to be an indirect holder of a
security or has no choice because we are issuing the securities only in global
form.

For example, once we make a payment or give a notice to the holder, we have
no further responsibility for the payment or notice even if that holder is
required, under agreements with depositary participants or customers or by law,
to pass it along to the indirect holders but does not do so. Similarly, we may
want to obtain the approval of the holders to amend an indenture, to relieve us
of the consequences of a default or of our obligation to comply with a
particular provision of the indenture or for other purposes. In such an event,
we would seek approval only from the holders, and not the indirect holders, of
the securities. Whether and how the holders contact the indirect holders is up
to the holders.

Special Considerations for Indirect Holders

If you hold securities through a bank, broker or other financial
institution, either in book-entry form or in street name, you should check with
your own institution to find out:

. how it handles securities payments and notices;

. whether it imposes fees or charges;

. how it would handle a request for the holders' consent, if ever required;

. whether and how you can instruct it to send you securities registered in
your own name so you can be a holder, if that is permitted in the future;

. how it would exercise rights under the securities if there were a default
or other event triggering the need for holders to act to protect their
interests; and

. if the securities are in book-entry form, how the depositary's rules and
procedures will affect these matters.

Global Securities

A global security is a security held by a depositary which represents one or
any other number of individual securities. Generally, all securities
represented by the same global securities will have the same terms.

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Each security issued in book-entry form will be represented by a global
security that we deposit with and register in the name of a financial
institution or its nominee that we select. The financial institution that we
select for this purpose is called the depositary. Unless we specify otherwise
in the applicable prospectus supplement, The Depository Trust Company, New
York, New York, known as DTC, will be the depositary for all securities issued
in book-entry form.

A global security may not be transferred to or registered in the name of
anyone other than the depositary, its nominee or a successor depositary, unless
special termination situations arise. We describe those situations below under
"--Special Situations When a Global Security Will Be Terminated." As a result
of these arrangements, the depositary, or its nominee, will be the sole
registered owner and holder of all securities represented by a global security,
and investors will be permitted to own only beneficial interests in a global
security. Beneficial interests must be held by means of an account with a
broker, bank or other financial institution that in turn has an account with
the depositary or with another institution that does. Thus, an investor whose
security is represented by a global security will not be a holder of the
security, but only an indirect holder of a beneficial interest in the global
security.

If the prospectus supplement for a particular security indicates that the
security will be issued in global form only, then the security will be
represented by a global security at all times unless and until the global
security is terminated. If termination occurs, we may issue the securities
through another book-entry clearing system or decide that the securities may no
longer be held through any book-entry clearing system.

Special Considerations for Global Securities

As an indirect holder, an investor's rights relating to a global security
will be governed by the account rules of the investor's financial institution
and of the depositary, as well as general laws relating to securities
transfers. We do not recognize an indirect holder as a holder of securities and
instead deal only with the depositary that holds the global security.

If securities are issued only in the form of a global security, an investor
should be aware of the following:

. An investor cannot cause the securities to be registered in his or her
name, and cannot obtain non-global certificates for his or her interest in
the securities, except in the special situations we describe below;

. An investor will be an indirect holder and must look to his or her own
bank or broker for payments on the securities and protection of his or her
legal rights relating to the securities, as we describe under "--Legal
Ownership of Securities" above;

. An investor may not be able to sell interests in the securities to some
insurance companies and to other institutions that are required by law to
own their securities in non-book-entry form;

. An investor may not be able to pledge his or her interest in a global
security in circumstances where certificates representing the securities
must be delivered to the lender or other beneficiary of the pledge in
order for the pledge to be effective;

. The depositary's policies, which may change from time to time, will govern
payments, transfers, exchanges and other matters relating to an investor's
interest in a global security. We and any applicable trustee have no
responsibility for any aspect of the depositary's actions or for its
records of ownership interests in a global security. We and the trustee
also do not supervise the depositary in any way;

. The depositary may, and we understand that DTC will, require that those
who purchase and sell interests in a global security within its book-entry
system use immediately available funds, and your broker or bank may
require you to do so as well; and

. Financial institutions that participate in the depositary's book-entry
system, and through which an investor holds its interest in a global
security, may also have their own policies affecting payments, notices and
other matters relating to the securities. There may be more than one
financial intermediary

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in the chain of ownership for an investor. We do not monitor and are not
responsible for the actions of any of those intermediaries.

Special Situations When a Global Security will be Terminated

In a few special situations described below, the global security will
terminate and interests in it will be exchanged for physical certificates
representing those interests. After that exchange, the choice of whether to
hold securities directly or in street name will be up to the investor.
Investors must consult their own banks or brokers to find out how to have their
interests in securities transferred to their own name, so that they will be
direct holders. We have described the rights of holders and street name
investors above.

The global security will terminate when the following special situations
occur:

. if the depositary notifies us that it is unwilling, unable or no longer
qualified to continue as depositary for that global security and we do not
appoint another institution to act as depositary within 90 days;

. if we notify any applicable trustee that we wish to terminate that global
security; or

. if an event of default has occurred with regard to securities represented
by that global security and has not been cured or waived.

The prospectus supplement may also list additional situations for
terminating a global security that would apply only to the particular series of
securities covered by the prospectus supplement. When a global security
terminates, the depositary, and not we or any applicable trustee, is
responsible for deciding the names of the institutions that will be the initial
direct holders.

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DILUTION

Our net tangible book value at September 30, 2001 was approximately $73.5
million, or $1.86 per share of common stock. Net tangible book value per share
represents our tangible net worth (tangible assets less total liabilities)
divided by the number of shares of common stock outstanding as of September 30,
2001. After giving effect to the issuance and sale of the securities offered by
us in this offering (at an assumed public offering price of $3.55 per share
based on the closing stock price per share for our common stock as reported on
the Nasdaq National Market on February 13, 2002, and assuming all securities
are shares of common stock and are all available for sale and are all sold in
this offering) and the receipt of the net proceeds of $39.3 million from the
sale of these shares, our net tangible book value as of September 30, 2001
would have been $112.8 million, or $2.23 per share. This represents an
immediate increase in the net tangible book value to existing stockholders of
$0.37 per share and an immediate dilution to new investors of $1.32 per share.
The following table illustrates this per share dilution:

[Enlarge/Download Table]

Assumed public offering price per share..................................... $3.55
Net tangible book value per share at December 31, 2000..................... $1.86
Increase in net tangible book value per share attributable to new investors 0.37
-----

Net tangible book value per share after this offering....................... 2.23
-----
Dilution per share to new investors......................................... $1.32
=====

The foregoing table is based on the number of shares of common stock
outstanding after this offering and exclude the following:

. 4,809,284 shares of common stock which we may issue upon the exercise of
options outstanding as of December 31, 2001 at a weighted average exercise
price of $5.81 per share; and

. 1,744,557 shares of common stock which we may issue upon the exercise of
warrants outstanding as of December 31, 2001 at a weighted average
exercise price of $4.66 per share.

To the extent the options or warrants are exercised, there will be further
dilution to the new investors. In addition, this information does not include
6,622,951 shares of common stock issued in connection with our acquisition of
Lifecodes Corporation in December 2001.

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PLAN OF DISTRIBUTION

The securities being offered may be sold in one or more transactions at
fixed prices, at prevailing market prices at the time of sale, at prices
related to the prevailing market prices, at varying prices determined at the
time of sale, or at negotiated prices. These sales may be effected at various
times in one or more of the following transactions, or in other kinds of
transactions:

. through underwriters for resale to the public or investors:

. transactions on the Nasdaq National Market or on any national securities
exchange or U.S. inter-dealer system of a registered national securities
association on which our common stock may be listed or quoted at the time
of sale;

. in the over-the-counter market;

. in private transactions and transactions otherwise than on these exchanges
or systems or in the over-the-counter market;

. in connection with short sales of the shares;

. by pledge to secure debt and other obligations;

. through the writing of options, whether the options are listed on an
options exchange or otherwise;

. in connection with the writing of non-traded and exchange-traded call
options, in hedge transactions and in settlement of other transactions in
standardized or over-the-counter options;

. through a combination of any of the above transactions; or

. any other method permitted by law.

We may sell our securities directly to one or more purchasers or to or
through underwriters, dealers or agents. The related prospectus supplement will
set forth the terms of each offering, including:

. the name or names of any agents, dealers or underwriters;

. the purchase price of the securities being offered and the proceeds we
will receive from the sale;

. any over-allotment options under which underwriters may purchase
additional securities from us;

. any agency fees or underwriting discounts and other items constituting
agents' or underwriters' compensation (the maximum underwriting
compensation in connection with any offering under this registration
statement will not exceed 8% of the maximum proceeds);

. any discounts or concessions allowed or reallowed or paid to dealers; and

. any securities exchanges on which such securities may be listed.

The selling stockholders and their successors, including their transferees,
pledgees or donees or their successors, may sell the common stock directly to
purchasers or through underwriters, broker-dealers or agents, who may receive
compensation in the form of discounts, concessions or commissions from the
selling stockholders or the purchasers. These discounts, concessions or
commissions as to any particular underwriter, broker-dealer or agent may be in
excess of those customary in the types of transactions involved.

In addition, any securities covered by this prospectus which qualify for
sale pursuant to Rule 144 or Regulation S of the Securities Act may be sold
under Rule 144 or Regulation S rather than pursuant to this prospectus.

From time to time the selling stockholders may engage in short sales, short
sales against the box, puts and calls and other transactions in securities of
the Company or derivatives thereof, and may sell and deliver the shares of
common stock in connection therewith. From time to time the selling
stockholders may pledge their shares pursuant to the margin provisions of the
customer agreements with their brokers. Upon a default by the selling
stockholders, the brokers may offer and sell the pledged shares of Common Stock
from time to time.

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The selling stockholders and any brokers participating in such sales may be
deemed to be underwriters within the meaning of the Securities Act. There can
be no assurance that the selling stockholders will sell any or all of the
shares of Common Stock offered hereunder.

We entered into registration rights agreements for the benefit of the
selling stockholders to register our common stock under applicable federal and
state securities laws. The registration rights agreements provide for
cross-indemnification of the selling stockholders and us and our respective
directors, officers and controlling persons against specific liabilities in
connection with the offer and sale of the common stock, including liabilities
under the Securities Act. We will pay substantially all of the expenses
incurred by the selling stockholders incident to the offering and sale of the
common stock; provided, that each selling stockholder will be responsible for
payment of commissions, concessions and discounts of underwriters,
broker-dealers or agents.

LEGAL MATTERS

The validity of the securities offered in this prospectus will be passed
upon for Orchid BioSciences, Inc. by Mintz, Levin, Cohn, Ferris, Glovsky and
Popeo, P.C. of Boston, Massachusetts. Certain attorneys at Mintz, Levin, Cohn,
Ferris, Glovsky and Popeo, P.C. beneficially own an aggregate of 8,100 shares
of our common stock. The validity of the securities offered in this prospectus
will be passed upon for any underwriters, dealers or agents by counsel which we
will name in the applicable prospectus supplement.

EXPERTS

The consolidated financial statements and schedule of Orchid BioSciences,
Inc. and subsidiaries as of December 31, 2000 and 1999, and for each of the
years in the three-year period ended December 31, 2000, have been incorporated
by reference herein and in the registration statement in reliance upon the
report of KPM LLP, independent accountants, incorporated by reference herein,
and upon the authority of said firm as experts in accounting and auditing.

The consolidated financial statements of GeneScreen, Inc. and subsidiaries
as of December 29, 1999, and for the period from January 1, 1999 to December
29, 1999, have been included herein and in the registration statement in
reliance upon the report of KPMG LLP, independent accountants, appearing
elsewhere herein, and upon the authority of said firm as experts in accounting
and auditing.

WHERE YOU CAN FIND MORE INFORMATION

We file annual, quarterly and special reports, proxy statements and other
information with the SEC. You may inspect and copy such material at the public
reference facilities maintained by the SEC at Room 1200, 450 Fifth Street,
N.W., Washington, D.C. 20549. You may also obtain copies of such material from
the SEC at prescribed rates by wiring to the Public Reference Section of the
SEC, 450 Fifth Street, N.W., Washington, D.C. 20549. Please call the SEC at
1-800-SEC-0330 for further information on the public reference rooms. Our
filings are also available to the public from the SEC's web site at www.sec.gov.

Our common stock is quoted on the Nasdaq National Market. You may inspect
reports and other information concerning us at the offices of the National
Association of Securities Dealers, Inc., 1735 K Street, N.W., Washington, D.C.
20006.

This prospectus is only part of a Registration Statement on Form S-3 that we
have filed with the SEC under the Securities Act and therefore omits certain
information contained in the Registration Statement. We have also filed
exhibits and schedules with the Registration Statement that are excluded from
this prospectus,

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and you should refer to the applicable exhibit or schedule for a complete
description of any statement referring to any contract or other document. You
may inspect a copy of the Registration Statement, including the exhibits and
schedules, without charge at the public reference room, or obtain a copy from
the SEC upon payment of the fee prescribed by the SEC. You may also view the
Registration Statement, including the exhibits and schedules, on the SEC's web
site at www.sec.gov.

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The SEC allows us to "incorporate" into this prospectus information that we
file with the SEC in other documents. This means that we can disclose important
information to you by referring to other documents that contain that
information. Any information that we incorporate by reference is considered
part of this prospectus. The documents and reports that we list below are
incorporated by reference into this prospectus. In addition, all documents and
reports which we file pursuant to Section 13(a), 13(c), 14 or 15(d) of the
Exchange Act of 1934 after the date of this prospectus and prior to the
termination of this offering are incorporated by reference in this prospectus
as of the respective filing dates of these documents and reports. Statements
contained in documents that we file with the SEC and that are incorporated by
reference in this prospectus will automatically update and supersede
information contained in this prospectus, including information in previously
filed documents or reports that have been incorporated by reference in this
prospectus, to the extent the new information differs from or is inconsistent
with the old information.

We have filed the following documents with the SEC. These documents are
incorporated herein by reference as of their respective dates of filing:

(1)Our Annual Report on Form 10-K for the year ended December 31, 2000;

(2)Our Quarterly Reports on Form 10-Q for the quarters ended:

. March 31, 2001;
. June 30, 2001; and
. September 30, 2001.

(3) Our Current Reports on Form 8-K filed with the SEC on:

. May 22, 2001;
. October 5, 2001;
. November 9, 2001;
. December 3, 2001; and
. December 19, 2001.

(4)Our Proxy Statement for the year ended December 31, 2000;

(5)All our filings pursuant to the Exchange Act after the date of filing
this initial registration statement and prior to effectiveness of the
registration statement; and

(6)The description of our common stock contained in our registration
statement on Form 8-A filed with the SEC on April 10, 2000, including
any amendments or reports filed for the purpose of updating that
description.

You may request a copy of these documents, which will be provided to you at
no cost by contacting us in writing at:

Investor Relations
Orchid BioSciences, Inc.
4390 US Route One
Princeton, New Jersey 08540

or by contacting us via telephone at (609) 750-2200.

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INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

[Enlarge/Download Table]

GeneScreen, Inc. and subsidiaries:
Consolidated Financial Statements:
Independent Auditors' Report...................................................... F-2
Consolidated Balance Sheet at December 29, 1999................................... F-3
Consolidated Statements of Operations for the period from January 1, 1999 to
December 29, 1999............................................................... F-4
Consolidated Statements of Stockholders' Equity (Deficit) for the period from
January 1, 1999 to December 29, 1999............................................ F-5
Consolidated Statement of Cash Flows for the period from January 1, 1999 to
December 29, 1999............................................................... F-6
Notes to Consolidated Financial Statements........................................ F-7

F-1

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INDEPENDENT AUDITORS' REPORT

The Board of Directors
GeneScreen, Inc. and Subsidiaries:

We have audited the accompanying consolidated balance sheet of GeneScreen,
Inc. and subsidiaries as of December 29, 1999, and the related consolidated
statements of operations, stockholders' equity (deficit), and cash flows for
the period from January 1, 1999 to December 29, 1999. These financial
statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audit.

We conducted our audit in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of
material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audit provides a reasonable basis
for our opinion.

In our opinion, the consolidated financial statements referred to above
present fairly, in all material respects, the financial position of GeneScreen,
Inc. and subsidiaries as of December 29, 1999, and the results of their
operations and their cash flows for the period from January 1, 1999 to December
29, 1999 in conformity with generally accepted accounting principles.

KPMG LLP

Princeton, New Jersey
January 21, 2000

F-2

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GENESCREEN, INC. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEET

December 29, 1999

[Enlarge/Download Table]

Assets
Current assets:
Cash......................................................................................... $ 538,411
Restricted cash.............................................................................. 400,000
Accounts receivable, net..................................................................... 2,228,554
Laboratory materials and supplies............................................................ 304,938
Prepaid expenses and other current assets.................................................... 156,108
-----------
Total current assets..................................................................... 3,628,011
Property and equipment, net..................................................................... 382,563
Note receivable................................................................................. 3,547,821
Other assets.................................................................................... 47,920
-----------
Total assets............................................................................. $ 7,606,315
===========
Liabilities and Stockholders' Deficit
Current liabilities:
Note payable--bank........................................................................... $ 1,000,000
Current portion of long-term debt............................................................ 190,352
Accounts payable............................................................................. 541,226
Accrued liabilities.......................................................................... 1,949,135
Deferred revenue............................................................................. 193,046
-----------
Total current liabilities................................................................ 3,873,759
Long-term debt, less current portion............................................................ 424,628
Deferred gain on sale of Molecular Tool......................................................... 3,570,646
-----------
Total liabilities........................................................................ 7,869,033
Commitments and contingencies
Stockholders' deficit:
Convertible preferred stock, Series A, $.05 par value; 350,000 shares authorized, issued and
outstanding (liquidation preference of $1,423,443 at December 29, 1999).................... 17,500
Convertible preferred stock, Series B, $.05 par value; 700,000 shares authorized; 691,723
shares issued and outstanding (liquidation preference of $2,964,630 at December 29, 1999).. 34,586
Common stock, $.01 par value; 10,000,000 shares authorized; 2,804,239 shares issued and
outstanding at December 29, 1999........................................................... 28,042
Additional paid-in capital................................................................... 8,896,451
Treasury stock--53 common shares, at cost.................................................... (22)
Accumulated deficit.......................................................................... (9,239,275)
-----------
Total stockholders' deficit.............................................................. (262,718)
-----------
Total liabilities and stockholders' deficit.............................................. $ 7,606,315
===========

See accompanying notes to consolidated financial statements.

F-3

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GENESCREEN, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENT OF OPERATIONS

Period from January 1, 1999 to December 29, 1999

[Download Table]

Revenue:
Laboratory testing................................ $13,746,615
-----------
Operating expenses:
Cost of laboratory testing........................ 10,054,681
General and administrative........................ 5,922,537
Research and development.......................... 97,909
-----------
Total operating expenses...................... 16,075,127
-----------
Operating loss................................ (2,328,512)
Other expense:
Interest expense.................................. (159,698)
-----------
Loss from continuing operations............... (2,488,210)
-----------
Discontinued operations:
Loss on discontinued operations of Molecular Tool. --
Gain on sale of Molecular Tool, net of tax........ 357,175
-----------
Total discontinued operations................. 357,175
-----------
Net loss...................................... $(2,131,035)
===========

See accompanying notes to consolidated financial statements.

F-4

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GENESCREEN, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT)

Period from January 1, 1999 to December 29, 1999

[Enlarge/Download Table]

Convertible preferred stock
-------------------------------
Series A Series B Common stock
--------------- --------------- -----------------
Number Number Number Additional Notes
of of of paid-in Treasury receivable -
shares Amount shares Amount shares Amount capital stock stockholders
------- ------- ------- ------- --------- ------- ---------- -------- ------------

Balance, January 1, 1999.................... 350,000 $17,500 691,723 $34,586 2,620,493 $26,205 7,695,716 (22) (36,563)
Exercise of common stock options............ -- -- -- -- 136,736 1,367 40,839 -- --
Cancellation of note receivable from
stockholder................................ -- -- -- -- -- -- -- -- 36,563
Common stock issued in exchange for
consulting services........................ -- -- -- -- 47,010 470 195,562 -- --
Net loss.................................... -- -- -- -- -- -- -- -- --
Accelerated vesting and cashless exercise of
common stock options....................... -- -- -- -- -- -- 964,334 -- --
------- ------- ------- ------- --------- ------- --------- --- -------
Balance, December 29, 1999.................. 350,000 $17,500 691,723 $34,586 2,804,239 $28,042 8,896,451 (22) --
======= ======= ======= ======= ========= ======= ========= === =======
[Download Table]

Accumulated
deficit Total
----------- ----------

Balance, January 1, 1999.................... (7,108,240) 629,182
Exercise of common stock options............ -- 42,206
Cancellation of note receivable from
stockholder................................ -- 36,563
Common stock issued in exchange for
consulting services........................ -- 196,032
Net loss.................................... (2,131,035) (2,131,035)
Accelerated vesting and cashless exercise of
common stock options....................... -- 964,334
---------- ----------
Balance, December 29, 1999.................. (9,239,275) (262,718)
========== ==========

See accompanying notes to consolidated financial statements.

F-5

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GENESCREEN, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENT OF CASH FLOWS

Period from January 1, 1999 to December 29, 1999

[Download Table]

Cash flows from operating activities:
Net loss........................................................ $(2,131,035)
Adjustments to reconcile net loss to net cash provided by
operating activities:
Gain on sale of Molecular Tool.............................. (357,175)
Depreciation and amortization............................... 384,309
Non-cash employee compensation.............................. 327,750
Common stock issued in exchange for consulting services..... 196,032
Non-cash compensation on accelerated vesting and
cashless exercise of common stock options................. 964,334
Loss on disposal of property and equipment.................. 59,566
Changes in assets and liabilities:
Accounts receivable...................................... 712,006
Laboratory materials and supplies........................ 108,854
Prepaid expenses and other current assets................ 56,864
Accounts payable......................................... (766,314)
Accrued liabilities...................................... 751,753
Deferred revenue......................................... (14,108)
-----------
Net cash provided by operating activities............ 292,836
-----------
Cash flows from investing activities:
Additions to property and equipment............................. (188,424)
Increase in restricted cash..................................... (400,000)
Proceeds from sale of Molecular Tool............................ 357,175
-----------
Net cash used in investing activities................ (231,249)
-----------
Cash flows from financing activities:
Net payments under line of credit............................... (130,000)
Payments on long-term obligations............................... (1,308,684)
Exercise of common stock options................................ 42,206
-----------
Net cash used in financing activities................ (1,396,478)
-----------
Net decrease in cash............................................... (1,334,891)
Cash at beginning of year.......................................... 1,873,302
-----------
Cash at end of year................................................ $ 538,411
===========
Supplemental disclosure of cash flow information:
Cash payments during the period for:
Interest.................................................... $ 314,164
Income taxes................................................ 245,000
===========
Supplemental disclosure of non-cash financing activities:
Notes payable issued and notes receivable cancelled in exchange
for employee severance and settlement agreements.............. $ 327,750
===========

See accompanying notes to consolidated financial statements.

F-6

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

December 29, 1999

(1) Summary of Significant Accounting Policies

Organization and Business Activities

GeneScreen, Inc. ("GeneScreen" or the "Company") operates genetic testing
laboratories in Dallas, Texas; Dayton, Ohio (acquired in 1992); and Sacramento,
California (acquired in 1994). GeneScreen performs paternity testing, forensic
identification testing to assist in criminal investigations and medical genetic
testing using technologies developed at the University of Texas Southwestern
Medical Center and other medical research facilities. GeneScreen's primary
sources of revenue represent paternity testing under contracts with several
state government agencies and genetic testing under grants from the National
Marrow Donor Program.

On September 11, 1998, the Company sold the assets of its Molecular Tool
("MTool") division to Orchid BioSciences, Inc. ("Orchid") (see Note 2). Prior
to this sale, MTool performed research and development activities for third
parties under contract and for its own account and developed and patented a
proprietary technology called SNP-IT primer-extension technology ("SNP-IT") for
the analysis of DNA.

GeneScreen was acquired by Orchid on December 30, 1999 (see Note 11).

Consolidated Financial Statements

The consolidated financial statements include the accounts of GeneScreen and
its wholly owned subsidiaries. Significant intercompany balances and
transactions are eliminated in consolidation.

Use of Estimates

Financial statement preparation requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingencies at the date of the financial statements and the
reported amounts of revenues and expenses during the reporting period. Actual
results could differ from those estimates.

Laboratory Materials and Supplies

Laboratory materials and supplies are stated at the lower of cost or market.
Cost is determined by the first-in, first-out (FIFO) method.

Property and Equipment

Property and equipment are stated at cost. Depreciation on equipment is
calculated on the straight-line method over the estimated useful lives of the
assets, which range from two to seven years. Leasehold improvements are
amortized straight line over the shorter of the lease term or estimated useful
life of the asset.

Financial Instruments

Financial instruments consist of cash, accounts and notes receivable,
payables and notes payable, the carrying value of which approximate their fair
values due to their short maturities or current interest rates.

Revenue Recognition

Revenue is recognized on an accrual basis at the time test results are
reported. Deferred revenue represents the unearned portion of payments received
in advance of tests being completed. Unbilled receivables represent revenue
which has been earned on completed tests which have not been billed to the
customer.

F-7

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

Research and Development and Advertising

Costs incurred for research and product development and advertising are
expensed as incurred. The results of operations for the MTool research and
development facility sold during 1998 are reported as discontinued operations
(see note 2). Advertising costs totalled $47,262 in 1999.

Stock-based Compensation

The Company accounts for its stock-based compensation to employees in
accordance with the provisions of Accounting Principles Board ("APB") Opinion
No. 25, "Accounting for Stock Issued to Employees", and related
interpretations. As such, deferred compensation is recorded on the date of
issuance or grant as the excess of the fair value of the underlying stock over
the purchase or exercise price. Any deferred compensation is amortized over the
respective vesting periods of the equity instruments, if any. The Company has
adopted the disclosure provisions of Statement of Financial Accounting
Standards No. 123 ("SFAS No. 123"), "Accounting for Stock-Based Compensation,"
which permits entities to provide pro forma net income (loss) disclosures for
stock-based compensation as if the minimum value method defined in SFAS No. 123
had been applied. As required by SFAS No. 123, transactions with non-employees
in which goods or services are the consideration received for the issuance of
equity instruments are accounted for under the fair value based method.

Income Taxes

The Company accounts for income taxes in accordance with the asset and
liability method prescribed by Statement of Financial Accounting Standards No.
109, "Accounting for Income Taxes." Under this method, deferred tax liabilities
and assets are determined based on the difference between the financial
statement and tax basis of assets and liabilities using tax rates in effect for
the years in which the differences are expected to reverse. The measurement of
deferred tax assets is reduced, if necessary, by a valuation allowance for any
tax benefits which are not expected to be realized. The effect on deferred tax
assets and liabilities of a change in tax rates is recognized in the period
that such tax rate changes are enacted.

Impairment of Long-Lived Assets and Long-Lived Assets to be Disposed of

In accordance with SFAS No. 121, "Accounting for the Impairment of
Long-Lived Assets and for Long-Lived Assets to Be Disposed Of," the Company
reviews long-lived assets, certain identifiable intangibles and goodwill for
impairment whenever events or changes in circumstances indicate that the
carrying amount of an asset may not be recoverable. Recoverability of assets to
be held and used is measured by a comparison of the carrying amount of an asset
to the undiscounted future net cash flows expected to be generated by the
asset. If such assets are considered to be impaired, the impairment to be
recognized is measured by the amount by which the carrying amount of the assets
exceed the fair value of the assets. Assets to be disposed of are reported at
the lower of the carrying amount or fair value less costs to dispose.

(2) Discontinued Operations of Molecular Tool, Inc.

In May 1998, the Board of Directors approved a plan to sell the MTool
assets, except that the Company retained certain rights to the SNP-IT
technology of MTool to permit the Company to continue implementation of the
SNP-IT testing processes.

In September 1998, the MTool assets were acquired by Orchid. GeneScreen
received $2,806,807 in cash and $3,547,821 in a subordinated convertible note
receivable, and $380,000 was placed in escrow. The escrow was to be released to
GeneScreen by Orchid upon approval by certain Federal regulatory agencies of
Orchid as

F-8

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

a valid recipient of outstanding MTool grant funds. The note receivable of
$3,547,821, bears interest at 6% annually, and is due on September 11, 2008. As
part of this agreement, GeneScreen retained a lien on the existing MTool
patents until settlement of this note has occurred. This note was cancelled in
the acquisition of GeneScreen by Orchid (see note 11).

Of the gain which resulted from the sale of MTool, $3,927,821, which is
equal to the convertible note receivable plus the escrow, was deferred at
December 31, 1998, until the respective settlements of these items occur. The
convertible note receivable was cancelled as part of the acquisition by Orchid
(see note 11) and the escrow funds of $380,000 were received in 1999 and
$357,175 was recorded as a gain, net of tax.

F-9

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

(3) Accounts Receivable and Credit Risks

Accounts receivable at December 29, 1999, consists of the following:

[Download Table]

Billed trade receivables............ $1,615,315
Unbilled trade receivables.......... 831,705
----------
2,447,020
Less allowance for doubtful accounts 218,466
----------
Accounts receivable, net......... $2,228,554
==========

GeneScreen's accounts receivable are primarily composed of amounts owed by
government agencies. GeneScreen performs periodic credit evaluations of its
customers' financial condition and generally does not require a deposit from
government agencies or private institutions. GeneScreen believes private pay
accounts for paternity testing represent the most significant credit risk and
generally requires a deposit for all or a portion of the services to be
rendered. Credit losses have consistently been within management's estimates.

(4) Property and Equipment

Property and equipment at December 29, 1999 consists of the following:

[Download Table]

Laboratory and office equipment............... $1,950,268
Leasehold improvements........................ 151,955
----------
2,102,223
Less accumulated depreciation and amortization 1,719,660
----------
$ 382,563
==========

(5) Credit Facility and Debt

On November 30, 1999, the Company amended its revolving credit agreement.
Borrowings are available under this agreement for up to $1,000,000. The note
bears interest at prime plus 2% (10.5% at December 29, 1999) payable monthly,
and is collateralized by $400,000 of pledged cash and cash equivalents on
deposit at the financial institution until the loan is repaid. The note is also
secured by the tangible and intangible assets of the Company. The Company had
outstanding borrowings under its revolving credit agreement of $1,000,000 at
December 29, 1999. On January 20, 2000, the $1,000,000 was repaid.

F-10

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

Long-term debt at December 29, 1999, consists of the following:

[Enlarge/Download Table]

Note payable to former employee, due in 16 quarterly installments of $27,932,
commencing January 1, 1999, and one lump-sum payment of $51,013, due January 1,
1999, net of unamortized discount of $23,030 at December 29, 1999.............. $312,154
Note payable to employee, due in 12 quarterly installments of $25,514, commencing
January 1, 2000, net of unamortized discount of $21,037 at December 29, 1999... 285,131
Other............................................................................ 17,695
--------
614,980
Less current portion............................................................. 190,352
--------
Long-term debt, less current portion.......................................... $424,628
========

(6) Accrued Liabilities

Accrued liabilities at December 29, 1999 consists of the following:

[Download Table]

Employee compensation........................ $ 42,913
Professional fees for transaction with Orchid 529,375
Self-insurance reserve....................... 191,000
Royalties on licensed technology............. 906,107
State income taxes payable................... 30,226
Other........................................ 249,514
----------
$1,949,135
==========

(7) Income Taxes

As of December 29, 1999, the Company has approximately $5,074,000 of Federal
and $2,261,000 of state net operating loss ("NOL") carryforwards available to
offset future taxable income. The Federal and state NOL carryforwards will
begin expiring in 2003 and 2002, respectively, if not utilized.

The Tax Reform Act of 1986 ("the Act") provides for a limitation on the
annual use of NOL carryforwards (following certain ownership changes, as
defined by the Act) which could significantly limit the Company's ability to
utilize these carryforwards. The Company has experienced various ownership
changes, as defined by the Act, as a result of past financings and the
acquisition by Orchid (see note 11). Accordingly, the Company's ability to
utilize the aforementioned carryforwards may be limited. Additionally, because
U.S. tax laws limit the time during which these carryforwards may be applied
against future taxes, the Company may not be able to take full advantage of
these attributes for Federal income tax purposes.

F-11

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

The tax effects of temporary differences that give rise to significant
portions of the deferred tax assets and liabilities, consists of the following
at December 29, 1999:

[Download Table]

Current:
Allowances and accruals, not currently deductible....... $ 165,862
Less valuation allowance................................ (165,862)
-----------
$ --
===========
Long-term:
Net operating loss carryforward......................... 2,033,358
Depreciation and amortization, not currently deductible. 164,254
Allowances and accruals, not currently deductible....... 199,511
Deferred gain on sale of MTool, currently taxable....... 434,353
Other................................................... (13,991)
-----------
2,817,485
Less valuation allowance................................ (2,817,485)
-----------
Net deferred taxes.................................. $ --
===========

At December 29, 1999, a valuation of allowance of $2,983,347 has been
recognized to fully offset the deferred tax assets as it is more likely than
not that these assets will not be realized. The change in the valuation
allowance in 1999 was an increase of $678,755, related primarily to additional
net operating losses incurred by the Company.

(8) Stockholders' Equity (Deficit)

Preferred Stock

The Company is authorized to issue a total of 5,000,000 shares of various
series of preferred stock. The Series A and Series B preferred stocks are
convertible into common stock on a 1-for-1 basis, subject to adjustment for
dilution, are entitled to vote with common stock on the basis of common shares
into which they are convertible, and provide for noncumulative annual dividends
at rates of $.20 and $.26 per share, respectively, when and if declared.

The Series A and Series B preferred stocks may be redeemed in whole or in
part, at the Company's option, at any time beginning after March 31, 1999 and
January 31, 2003, respectively. The per share redemption price for Series A is
$2.50 plus approximately $.20 for each year outstanding since February 1992.
The per share redemption price for Series B is $3.28 plus approximately $.02
for each month outstanding since February 1996. For both series, the
liquidation value is computed in the same manner as the redemption price. The
Series A and Series B preferred stocks have a liquidation preference over
common stock.

All shares of the Series A and Series B preferred stocks will automatically
convert to common stock upon the sale of the Company's common stock in a public
offering, subject to certain offering criteria. At December 29, 1999, the
Company has reserved approximately 1,050,000 shares of common stock for
issuance upon conversion of all preferred stock (see note 11).

F-12

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

Common Stock

During 1999, a member of GeneScreen's Board of Directors provided consulting
services to the Company in exchange for total consideration of $289,277,
consisting of $93,245 in cash and 47,010 shares of common stock valued at
$196,032.

(9) Stock Option Plan

Under the Stock Option Plan (the "Plan"), options to purchase up to 686,667
shares of common stock may be granted to certain key employees and officers of
the Company. Options are exercisable immediately and expire no later than ten
years from the date of grant. The Board may determine the individuals to whom
and the time at which options shall be granted and the number of shares of
common stock covered by each option. The exercise price per share will be
determined by the Board but may not be less than 85% of the fair value of the
common stock on the date of grant. Common stock issued related to the options
is subject to repurchase by GeneScreen upon termination of employment. The
percentage of stock eligible for repurchase will decrease ratably over a period
varying from three to five years from the date of grant. Options for stock no
longer eligible for repurchase are considered fully vested (see note 11).

The following is a summary of the Plan's activity for the period shown:

[Download Table]

Weighted
average
exercise
Number of price per
shares share
--------- ---------

Options outstanding, January 1, 1999.. 511,079 $.41
Granted............................ 172,500 .80
Exercised.......................... (136,736) .31
Terminated......................... (22,396) .59
--------
Options outstanding, December 31, 1999 524,447 .55
========

The following table summarizes information for options outstanding and
vested at December 29, 1999:

[Download Table]

Options outstanding Options vested
------------------------------ ------------------
Weighted
average Weighted Weighted
remaining average average
Range of exercise Number of contractual exercise Number of exercise
prices shares life price shares price
----------------- --------- ----------- -------- --------- --------

$.12 167,747 1.7 $.12 167,747 $.12
.25 20,000 2.5 .25 20,000 .25
.50 14,600 4.0 .50 14,600 .50
.80 322,100 7.9 .80 107,075 .80
------- -------
524,447 5.6 .55 309,422 .38
======= =======

F-13

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

Immediately prior to Orchid's acquisition of the Company, all unvested stock
options were subject to accelerated vesting and all outstanding options were
exercised (on a cashless basis) for shares of GeneScreen common stock,
resulting in compensation expense of $964,334, which is reflected in the
consolidated statement of operations for 1999.

The Company applies the provisions of APB No. 25 and related interpretations
in accounting for its stock option plan. No compensation cost has been
recognized for its stock option plan, since the fair market value of the common
stock at the date of grant was not in excess of the option exercise price. Had
compensation cost for the Company's stock option plan been determined based on
the minimum value of the options at the grant dates consistent with the method
prescribed by SFAS No. 123, the Company's pro forma net loss would have been
$2,170,710 in 1999.

In the pro forma calculations, the weighted average minimum value of options
granted in 1999 was estimated at $.23. The minimum value of each option grant
is estimated on the date of grant using the minimum value method with the
following weighted average assumptions used for grants in 1999: risk free
interest rate of 5.6%; expected life of six years; no dividend yield; and no
expected volatility (because the Company's stock is not publicly traded).

(10) Commitments and Contingencies

Leases

The Company leases its facilities under noncancellable operating leases with
options to renew. Future minimum rental payments as of December 29, 1999, are
as follows:

[Download Table]

2000............................................................ $292,527
2001............................................................ 242,984
2002............................................................ 87,861
--------
$623,372
========

Rent expense in 1999 was $322,270.

Self-Insurance Reserve

The Company is self-insured for the risk of loss relating to certain
litigation claims that might arise from the Company's testing results. However,
due to provisions in certain service contracts, the Company is insured for
claims arising from testing performed under the Texas, Ohio and Arizona
contracts. Insurance coverage began in 1995 for testing under the Texas
contract, in 1997 for testing under the Ohio and Arizona contracts and all
other contracts in August 1998. Management estimates future litigation costs
based on historical litigation experience. The accrued litigation reserve for
the self-insured risk at December 29, 1999 was $191,000.

Employment Contracts

Under a 1992 employment contract, the Company was contingently liable to one
individual through December 31, 2001, for minimum payments in the event of
involuntary termination or death of this individual. In 1999, the Company
agreed to a settlement agreement with the employee with a net cost of $327,750,
which

F-14

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GENESCREEN, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS--(Continued)

December 29, 1999

includes cancellation of a note receivable from the employee for $36,563 plus
accrued interest of $6,056. The settlement is payable in quarterly installments
over three years, the total of which has been recorded at a discounted amount
of $285,131 plus interest of $21,037 (see note 5).

(11) Acquisition of GeneScreen by Orchid

On December 30, 1999, Orchid acquired all of the outstanding shares of
common and preferred stock of GeneScreen in exchange for consideration
consisting primarily of 4,000,000 shares of Orchid Series E convertible
preferred stock ("Series E") (see note 9) with a stated value of $4.50 per
share. The Company estimates that approximately $300,000 will be paid in lieu
of issuing Series E shares to satisfy certain regulatory requirements and
eliminate fractional shares. This equates to 65,647 shares of Series E which
will not be issued. Also, as part of the acquisition, the note receivable from
Orchid of $3,547,821 was cancelled. GeneScreen incurred costs totaling $902,490
for fees to outside advisors related to this transaction which are included in
general and administrative expenses in the 1999 consolidated statements of
operations. Amounts included in the accompanying consolidated financial
statements are stated on a historical cost basis and do not reflect any fair
value adjustments which might result from the application of purchase
accounting as a result of the acquisition of the Company by Orchid.

F-15

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Filed on:	2/21/02	1		8-K, 8-K/A
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Filing Submission 0000927016-02-001107 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Orchid Cellmark Inc – ‘424B5’ on 2/21/02

On: Thursday, 2/21/02 · Accession #: 927016-2-1107 · File #: 333-60582

Prospectus — Rule 424(b)(5)Filing Table of Contents

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Dates Referenced Herein and Documents Incorporated by Reference

Prospectus — Rule 424(b)(5)
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