Avax Technologies Inc – ‘8-K’ for 7/26/00 – EX-99.4

On:  Wednesday, 7/26/00, at 2:00pm ET   ·   For:  7/26/00   ·   Accession #:  912057-0-33224   ·   File #:  0-29222

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Current Report   —   Form 8-K
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 8-K         Current Report                                         5     18K 
 2: EX-99.1     Miscellaneous Exhibit                                  2     12K 
 3: EX-99.2     Miscellaneous Exhibit                                  2     12K 
 4: EX-99.3     Miscellaneous Exhibit                                  2±    10K 
 5: EX-99.4     Miscellaneous Exhibit                                  2±    11K 
 6: EX-99.5     Miscellaneous Exhibit                                  2     14K 
 7: EX-99.6     Miscellaneous Exhibit                                  2     14K 

EX-99.4   —   Miscellaneous Exhibit

EX-99.4
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                                                                  EXHIBIT 99.4

                            Company Contact: Ernest W. Yankee, Ph.D.
                                             AVAX Technologies, Inc.
                                    (816) 960-1333

                              Investors/Media: Olga Fleming/Lisa Bradlow
                                                  CPR Financial Communications
                                    (201) 641-2408

 AVAX INITIATES A PHASE 1/2 STUDY OF L-VAX-TM- IN ACUTE MYELOGENOUS LEUKEMIA
 - STUDY AT M.D. ANDERSON CANCER CENTER EXTENDS APPLICATION OF THE
 AC VACCINE-TM- TECHNOLOGY TO FOURTH CANCER INDICATION -

KANSAS CITY, MO, MAY 15, 2000 -- AVAX TECHNOLOGIES, INC. (NASDAQ: AVXT) today   
announced that it has initiated a Phase 1/2 study of L-Vax-TM-, its autologous  
therapeutic cancer vaccine for leukemia, in patients with acute myelogenous     
leukemia (AML), a rapidly progressing cancer of the blood affecting immature    
cells of the bone marrow. The L-Vax vaccine will be prepared from blood samples 
of the patients obtained after their first relapse. Patients in second remission
will receive seven weekly L-Vax vaccinations followed by a six-month booster.   
The purpose of the study will be to evaluate L-Vax's ability to induce an immune
response against the patients' leukemia cells and to prevent or delay another   
relapse. Approximately 40 patients will participate in the study. As with all   
applications of the AC Vaccine technology, the L-Vax vaccine will be an         
individualized therapy for cancer manufactured at AVAX's centralized            
manufacturing facility.                                                         

The Phase 1/2 trial is being directed by Guillermo Garcia-Manero M.D., Assistant
Professor of Medicine, The University of Texas M.D. Anderson Cancer Center, in  
collaboration with David Berd, M.D., Professor of Medicine, Thomas Jefferson    
University, the inventor of the AC Vaccine-TM- technology. Over 10,000 new cases
of acute myelogenous leukemia are diagnosed annually in the U.S. Currently, the 
only therapy available to patients is intensive chemotherapy, sometimes with    
bone marrow transplant. Patients who achieve a remission after chemotherapy have
a high rate of relapse (50-80%). Following relapse, few patients achieve another
remission even with further chemotherapy.                                       

Jeffrey M. Jonas, M.D., President and CEO of AVAX Technologies, Inc., stated,   
"We are very pleased to be working with the M.D. Anderson Cancer Center to begin
evaluating the AC Vaccine technology in a fourth tumor type, AML. This study    
further demonstrates that not only are we able to manufacture an autologous     
vaccine from solid tumors, but also from tumor cells in blood. Results from this
study will enhance ongoing activities in our other studies in melanoma, ovarian 
and breast cancers, and further support additional new studies in other cancer  
indications."                                                                   

AVAX's AC Vaccines are made from the patient's own cancer cells by    
modifying the tumor cells with a molecule called a "hapten." This process, known
as "haptenization," alters the tumor cells and makes them appear foreign to the 
patient's immune system. When the hapten-modified cells are injected into       
patients, they stimulate the immune system to recognize the cancer cells and    
destroy them. The company's lead product candidate, M-Vax-TM-, is currently     
being evaluated in a multi-center pivotal registration for stage III melanoma   
and in a Phase 2 trial for stage IV melanoma. To date, more than 350 patients   
have been treated with M-Vax, which has received orphan drug status in the U.S. 
M-Vax is expected to become commercially available to patients in Australia by  
mid-2000. The AC Vaccine technology is also being evaluated in a Phase 2 trial  
in ovarian cancer and in Japan for use in the treatment of breast cancer.       

AVAX Technologies, Inc. specializes in the development and commercialization of 
novel biotechnologies, immunotherapies and pharmaceuticals for cancer and other 
life-threatening diseases using three core technologies: autologous cell (AC)   
vaccines, topoisomerase inhibitors and anti-estrogens.                          

 # # #

EXCEPT FOR STATEMENTS THAT ARE HISTORICAL, THE STATEMENTS IN THIS RELEASE ARE   
"FORWARD-LOOKING" STATEMENTS THAT ARE MADE PURSUANT TO THE SAFE HARBOR          
PROVISIONS OF SECTION 27A OF THE SECURITIES ACT OF 1933 AND SECTION 21E OF THE  
SECURITIES EXCHANGE ACT OF 1934. FORWARD-LOOKING STATEMENTS INVOLVE SIGNIFICANT 
RISKS AND UNCERTAINTIES, AND IN LIGHT OF THE SIGNIFICANT UNCERTAINTIES INHERENT 
IN SUCH STATEMENTS, THE INCLUSION OF SUCH INFORMATION SHOULD NOT BE REGARDED AS 
A REPRESENTATION BY AVAX THAT THE OBJECTIVES AND PLANS OF THE COMPANY WILL BE   
ACHIEVED. IN FACT, ACTUAL RESULTS COULD DIFFER MATERIALLY FROM THOSE            
CONTEMPLATED BY SUCH FORWARD-LOOKING STATEMENTS. MANY IMPORTANT FACTORS AFFECT  
THE COMPANY'S ABILITY TO ACHIEVE THE STATED OUTCOMES AND TO DEVELOP SUCCESSFULLY
AND COMMERCIALIZE ITS PRODUCT CANDIDATES, INCLUDING THE ABILITY TO OBTAIN AND   
MAINTAIN ALL NECESSARY PATENTS OR LICENSES, TO DEMONSTRATE THE SAFETY AND       
EFFICACY OF PRODUCT CANDIDATES AT EACH STAGE OF DEVELOPMENT, TO MEET APPLICABLE 
REGULATORY STANDARDS AND RECEIVE REQUIRED REGULATORY APPROVALS, TO MEET         
OBLIGATIONS AND REQUIRED MILESTONES UNDER ITS LICENSE AGREEMENTS, TO BE CAPABLE 
OF PRODUCING DRUG CANDIDATES IN COMMERCIAL QUANTITIES AT REASONABLE COSTS, TO   
COMPETE SUCCESSFULLY AGAINST OTHER PRODUCTS, TO OBTAIN SUBSTANTIAL ADDITIONAL   
FUNDS, AND TO MARKET PRODUCTS IN A PROFITABLE MANNER, AS WELL AS OTHER RISKS    
DETAILED FROM TIME TO TIME IN AVAX'S PUBLIC DISCLOSURE FILINGS WITH THE         
SECURITIES AND EXCHANGE COMMISSION, INCLUDING ITS ANNUAL REPORT ON FORM 10-KSB  
FOR THE YEAR ENDED DECEMBER 31,1999. AVAX DOES NOT UNDERTAKE ANY OBLIGATION TO  
RELEASE PUBLICLY ANY REVISIONS TO THESE FORWARD-LOOKING STATEMENTS OR TO REFLECT
THE OCCURRENCE OF UNANTICIPATED EVENTS.                                         

Dates Referenced Herein   and   Documents Incorporated by Reference

This ‘8-K’ Filing		Date		Other Filings
Filed on / For Period End:		7/26/00		8-K
		5/15/00
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