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<!-- DFIN ActiveDisclosure(SM) XBRL Linkbase Document - http://www.dfinsolutions.com/ --> |
<!-- Creation Date : 2020-02-26T23:20:35.0401273+00:00 --> |
<!-- Version : 5.0.1.321 --> |
<!-- Package ID : 52d8470d02d34164aa8556076700b3c7 --> |
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| | <link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems" xlink:to="hrtx_PaymentsOfDebtAccruedInterest" order="12850.00" priority="2" use="optional"/> |
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| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions"/> |
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| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance" xlink:type="locator" xlink:label="us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:type="locator" xlink:label="us-gaap_CommonStockSharesIssued"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/> |
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| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_SharebasedCompensationArrangementBySharebasedPaymentAwardDiscountOnStockPrice" xlink:type="locator" xlink:label="hrtx_SharebasedCompensationArrangementBySharebasedPaymentAwardDiscountOnStockPrice"/> |
| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_SharebasedCompensationArrangementBySharebasedPaymentAwardMaximumEmployeeEarningsWithHeldToPurchaseCommonStockPercent" xlink:type="locator" xlink:label="hrtx_SharebasedCompensationArrangementBySharebasedPaymentAwardMaximumEmployeeEarningsWithHeldToPurchaseCommonStockPercent"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/> |
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| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:type="locator" xlink:label="us-gaap_ProceedsFromIssuanceOfWarrants"/> |
| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_StockIssuedDuringPeriodSharesWarrantsExercised" xlink:type="locator" xlink:label="hrtx_StockIssuedDuringPeriodSharesWarrantsExercised"/> |
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| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:type="locator" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:type="locator" xlink:label="us-gaap_PaymentsOfStockIssuanceCosts"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharePrice" xlink:type="locator" xlink:label="us-gaap_SharePrice"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues"/> |
| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_EquityIncentivePlan2007Member" xlink:type="locator" xlink:label="hrtx_EquityIncentivePlan2007Member"/> |
| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_EmployeeStockPurchasePlanMember" xlink:type="locator" xlink:label="hrtx_EmployeeStockPurchasePlanMember"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:type="locator" xlink:label="us-gaap_PlanNameDomain"/> |
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| | <link:loc xlink:href="hrtx-20191231.xsd#hrtx_PreFundedWarrantsMember" xlink:type="locator" xlink:label="hrtx_PreFundedWarrantsMember"/> |
| | <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:type="locator" xlink:label="us-gaap_SaleOfStockNameOfTransactionDomain"/> |
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