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Rubius Therapeutics, Inc. – ‘10-K’ for 12/31/20 – ‘EX-101.SCH’

On:  Tuesday, 2/23/21, at 8:43am ET   ·   For:  12/31/20   ·   Accession #:  1558370-21-1412   ·   File #:  1-38586

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/23/21  Rubius Therapeutics, Inc.         10-K       12/31/20   82:12M                                    Toppan Merrill Bridge/FA

Annual Report   —   Form 10-K
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.86M 
 2: EX-21.1     Subsidiaries List                                   HTML     23K 
 3: EX-23.1     Consent of Expert or Counsel                        HTML     23K 
 4: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 5: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 6: EX-32.1     Certification -- §906 - SOA'02                      HTML     24K 
 7: EX-32.2     Certification -- §906 - SOA'02                      HTML     24K 
14: R1          Document and Entity Information                     HTML     88K 
15: R2          Consolidated Balance Sheets                         HTML    101K 
16: R3          Consolidated Balance Sheets (Parenthetical)         HTML     40K 
17: R4          Consolidated Statements of Operations and           HTML     70K 
                Comprehensive Loss                                               
18: R5          Consolidated Statements of Operations and           HTML     26K 
                Comprehensive Loss (Parenthetical)                               
19: R6          Consolidated Statements of Convertible Preferred    HTML    105K 
                Stock and Stockholders' Equity (Deficit)                         
20: R7          Consolidated Statements of Convertible Preferred    HTML     25K 
                Stock and Stockholders' Equity (Deficit)                         
                (Parenthetical)                                                  
21: R8          Consolidated Statements of Cash Flows               HTML    131K 
22: R9          Nature of the Business and Basis of Presentation    HTML     32K 
23: R10         Summary of Significant Accounting Policies          HTML    119K 
24: R11         Investments and Fair Value of Financial Assets and  HTML    120K 
                Liabilities                                                      
25: R12         Property, Plant and Equipment, Net                  HTML     64K 
26: R13         Debt                                                HTML     52K 
27: R14         Convertible Preferred Stock                         HTML     27K 
28: R15         Warrants to Purchase Convertible Preferred Stock    HTML     26K 
29: R16         Equity                                              HTML     29K 
30: R17         Stock-Based Compensation                            HTML    139K 
31: R18         Income Taxes                                        HTML     94K 
32: R19         Commitments and Contingencies                       HTML     30K 
33: R20         Leases                                              HTML     81K 
34: R21         Net Loss Per Share                                  HTML     56K 
35: R22         Related Parties                                     HTML     29K 
36: R23         Selected Quarterly Financial Data (Unaudited)       HTML     79K 
37: R24         Summary of Significant Accounting Policies          HTML    170K 
                (Policies)                                                       
38: R25         Summary of Significant Accounting Policies          HTML     87K 
                (Tables)                                                         
39: R26         Investments and Fair Value of Financial Assets and  HTML    121K 
                Liabilities (Tables)                                             
40: R27         Property, Plant and Equipment, Net (Tables)         HTML     47K 
41: R28         Accrued Expenses and Other Current Liabilities      HTML     38K 
                (Tables)                                                         
42: R29         Debt (Tables)                                       HTML     49K 
43: R30         Stock-Based Compensation (Tables)                   HTML    130K 
44: R31         Income Taxes (Tables)                               HTML     91K 
45: R32         Leases (Tables)                                     HTML     76K 
46: R33         Net Loss Per Share (Tables)                         HTML     57K 
47: R34         Selected Quarterly Financial Data (Unaudited)       HTML     79K 
                (Tables)                                                         
48: R35         Nature of the Business and Basis of Presentation    HTML     58K 
                (Details)                                                        
49: R36         Summary of Significant Accounting Policies          HTML     39K 
                (Details)                                                        
50: R37         Summary of Significant Accounting Policies -        HTML     37K 
                Estimated useful life (Details)                                  
51: R38         Summary of Significant Accounting Policies -        HTML    113K 
                Recently Adopted Accounting Pronouncements                       
                (Details)                                                        
52: R39         Investments and Fair Value of Financial Assets and  HTML     73K 
                Liabilities (Details)                                            
53: R40         Property, Plant and Equipment, Net (Details)        HTML     65K 
54: R41         Accrued Expenses and Other Current Liabilities      HTML     36K 
                (Details)                                                        
55: R42         Debt (Details)                                      HTML     82K 
56: R43         Debt - Current and Non current (Details)            HTML     35K 
57: R44         Convertible Preferred Stock (Details)               HTML     56K 
58: R45         Warrants to Purchase Convertible Preferred Stock    HTML     45K 
                (Details)                                                        
59: R46         Equity (Details)                                    HTML     62K 
60: R47         Stock-Based Compensation (Details)                  HTML     55K 
61: R48         Stock-Based Compensation - Employees, directors     HTML     31K 
                and non-employees (Details)                                      
62: R49         Stock-Based Compensation - Option activity          HTML     85K 
                (Details)                                                        
63: R50         Stock-Based Compensation - Performance based stock  HTML     84K 
                options (Details)                                                
64: R51         Stock-Based Compensation - Restricted Common Stock  HTML     87K 
                (Details)                                                        
65: R52         Stock-Based Compensation - Compensation expense     HTML     64K 
                (Details)                                                        
66: R53         Income Taxes (Details)                              HTML     48K 
67: R54         Income Taxes - U S federal statutory income tax     HTML     42K 
                rate (Details)                                                   
68: R55         Income Taxes - Net deferred tax assets (Details)    HTML     53K 
69: R56         Income Taxes - Valuation allowance for deferred     HTML     27K 
                tax assets (Details)                                             
70: R57         Commitments and Contingencies - Collaborative       HTML     31K 
                Arrangements and Non-collaborative Arrangement                   
                (Details)                                                        
71: R58         Commitments and Contingencies - Defined             HTML     31K 
                Contribution Plan (Details)                                      
72: R59         Leases (Details)                                    HTML     57K 
73: R60         Leases - Minimum lease payments (Details)           HTML     42K 
74: R61         Leases - Lease Portfolio (Details)                  HTML     47K 
75: R62         Net Loss Per Share - Weighted Average Shares        HTML     39K 
                (Details)                                                        
76: R63         Net Loss Per Share - Antidilutive Securities        HTML     35K 
                (Details)                                                        
77: R64         Related Parties (Details)                           HTML     66K 
78: R65         Selected Quarterly Financial Data (Unaudited)       HTML     41K 
                (Details)                                                        
80: XML         IDEA XML File -- Filing Summary                      XML    150K 
13: XML         XBRL Instance -- ruby-20201231x10k_htm               XML   2.26M 
79: EXCEL       IDEA Workbook of Financial Reports                  XLSX    114K 
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10: EX-101.DEF  XBRL Definitions -- ruby-20201231_def                XML    641K 
11: EX-101.LAB  XBRL Labels -- ruby-20201231_lab                     XML   1.50M 
12: EX-101.PRE  XBRL Presentations -- ruby-20201231_pre              XML   1.12M 
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81: JSON        XBRL Instance as JSON Data -- MetaLinks              398±   605K 
82: ZIP         XBRL Zipped Folder -- 0001558370-21-001412-xbrl      Zip    937K

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<element id="ruby_WarrantsContractualTerm" name="WarrantsContractualTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AmountRecordedInBalanceSheetDueToPromissoryNotesReceivedFromSaleOfCommonStock" name="AmountRecordedInBalanceSheetDueToPromissoryNotesReceivedFromSaleOfCommonStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AggregateMilestonePaymentsAchievementOfSpecifiedMilestones" name="AggregateMilestonePaymentsAchievementOfSpecifiedMilestones" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantDateFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ReclassificationOfWarrantsToAdditionalPaidInCapital" name="ReclassificationOfWarrantsToAdditionalPaidInCapital" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ConversionOfPreferredStockToCommonStockUponInitialPublicOffering" name="ConversionOfPreferredStockToCommonStockUponInitialPublicOffering" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AggregateStockSharesAuthorized" name="AggregateStockSharesAuthorized" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_PropertyAcquisitionArea" name="PropertyAcquisitionArea" nillable="true" type="num:areaItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualIncreasePercentage" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualIncreasePercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualIncrease" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualIncrease" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_EmployeesDirectorsAndNonEmployeesStockAwardsMember" name="EmployeesDirectorsAndNonEmployeesStockAwardsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredTaxAssetIncreaseDecreaseAmount" name="DeferredTaxAssetIncreaseDecreaseAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredTaxAssetsCapitalizedIntellectualPropertyCosts" name="DeferredTaxAssetsCapitalizedIntellectualPropertyCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpense" name="DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ValuationAllowanceDeferredTaxAssetIncreaseInIncomeTaxProvision" name="ValuationAllowanceDeferredTaxAssetIncreaseInIncomeTaxProvision" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredTaxLiabilitiesDepreciationAndOther" name="DeferredTaxLiabilitiesDepreciationAndOther" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_January2017PromissoryNoteMember" name="January2017PromissoryNoteMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_May2017PromissoryNoteMember" name="May2017PromissoryNoteMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_MaturityTermFromIssuanceDateOfPromissoryNotes" name="MaturityTermFromIssuanceDateOfPromissoryNotes" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_MaturityTermFromDateOfTerminationOfServicesFromBorrower" name="MaturityTermFromDateOfTerminationOfServicesFromBorrower" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_LongTermDebtNetOfCurrent" name="LongTermDebtNetOfCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_IncomeTaxBenefitsForNetOperatingLossesIncurred" name="IncomeTaxBenefitsForNetOperatingLossesIncurred" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_IncomeTaxBenefitsForResearchAndDevelopmentTaxCredits" name="IncomeTaxBenefitsForResearchAndDevelopmentTaxCredits" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredFinancingCostsPolicyTextBlock" name="DeferredFinancingCostsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ResearchAndManufacturingContractCostsAndAccrualsPolicyTextBlock" name="ResearchAndManufacturingContractCostsAndAccrualsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_PatentCostsPolicyTextBlock" name="PatentCostsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfCommonStock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfCommonStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_TwoThousandAndEighteenCreditFacilityMember" name="TwoThousandAndEighteenCreditFacilityMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentPeriodForCommencingPeriodicPayment" name="DebtInstrumentPeriodForCommencingPeriodicPayment" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentAmortizationPeriod" name="DebtInstrumentAmortizationPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentPrepaymentRateTwo" name="DebtInstrumentPrepaymentRateTwo" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentPrepaymentRateOne" name="DebtInstrumentPrepaymentRateOne" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentPrepaymentRateThree" name="DebtInstrumentPrepaymentRateThree" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_TwoThousandAndFifteenCreditFacilityMember" name="TwoThousandAndFifteenCreditFacilityMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_TermLoanMember" name="TermLoanMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentNumberOfTranche" name="DebtInstrumentNumberOfTranche" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_TenantImprovementRepayableToLandlord" name="TenantImprovementRepayableToLandlord" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_MarketBasedStockOptionsMember" name="MarketBasedStockOptionsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtInstrumentDebtDefaultAdditionalInterestRate" name="DebtInstrumentDebtDefaultAdditionalInterestRate" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_SharesWithheldToPayExercisePriceOfWarrants" name="SharesWithheldToPayExercisePriceOfWarrants" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DebtIssuanceCostsIncludedInAccountsPayableAndAccruedExpenses" name="DebtIssuanceCostsIncludedInAccountsPayableAndAccruedExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ShareBasedCompensationArrangementsByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisesInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisesInPeriodWeightedAverageExercisePrice" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_IncreaseDecreaseOperatingLeaseRightOfUseAsset" name="IncreaseDecreaseOperatingLeaseRightOfUseAsset" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_IncreaseDecreaseOperatingLeaseLiabilities" name="IncreaseDecreaseOperatingLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ServiceBasedStockOptionsMember" name="ServiceBasedStockOptionsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_EmbeddedLeaseContractsMember" name="EmbeddedLeaseContractsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_OperatingLeaseBaseRentIncrementalPercentage" name="OperatingLeaseBaseRentIncrementalPercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_NumberOfLeasedProperties" name="NumberOfLeasedProperties" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_NumberOfExpirationDates" name="NumberOfExpirationDates" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AccruedExpensesAndOtherCurrentLiabilitiesExcludingCurrentOperatingLeaseLiabilities" name="AccruedExpensesAndOtherCurrentLiabilitiesExcludingCurrentOperatingLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AccruedManufacturingFacilityExpensesCurrent" name="AccruedManufacturingFacilityExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AtMarketOfferingMember" name="AtMarketOfferingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_MaximumAggregateOfferingPriceOfStock" name="MaximumAggregateOfferingPriceOfStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_CommissionsAsPercentageOfGrossOfferingProceeds" name="CommissionsAsPercentageOfGrossOfferingProceeds" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_NumberOfOptionsToExtendLease" name="NumberOfOptionsToExtendLease" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AccruedGeneralAndAdministrativeExpensesCurrent" name="AccruedGeneralAndAdministrativeExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_USTreasuryBillsAndNotesMember" name="USTreasuryBillsAndNotesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_DeferredTaxAssetsOperatingLeaseLiabilities" name="DeferredTaxAssetsOperatingLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_CapitalizationOfBuildToSuitLeaseTransaction" name="CapitalizationOfBuildToSuitLeaseTransaction" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ProceedsFromStockOptionsExercisedInOtherCurrentAssets" name="ProceedsFromStockOptionsExercisedInOtherCurrentAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_RestrictedCashForBenefitOfLandlord" name="RestrictedCashForBenefitOfLandlord" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ManufacturingEquipmentMember" name="ManufacturingEquipmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_LeaseAssetDerecognizedUponLeaseCancellation" name="LeaseAssetDerecognizedUponLeaseCancellation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_FairValueMeasurementsInterTransfersBetweenLevels" name="FairValueMeasurementsInterTransfersBetweenLevels" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_AdjustmentToAdditionalPaidInCapitalConversionOfPreferredStockWarrantToCommonStockWarrant" name="AdjustmentToAdditionalPaidInCapitalConversionOfPreferredStockWarrantToCommonStockWarrant" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_ClassOfWarrantOrRightExerciseOfWarrantsNumberOfCommonStockSharesIssued" name="ClassOfWarrantOrRightExerciseOfWarrantsNumberOfCommonStockSharesIssued" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
<element id="ruby_MarketBasedAndServiceBasedVestingMember" name="MarketBasedAndServiceBasedVestingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema"/>
</xsd:schema>

3 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/18/21  Rubius Therapeutics, Inc.         8-K:1,9     3/16/21   12:582K                                   Toppan Merrill/FA
 3/18/21  Rubius Therapeutics, Inc.         424B5                  1:772K                                   Toppan Merrill/FA
 3/15/21  Rubius Therapeutics, Inc.         424B5                  1:774K                                   Toppan Merrill/FA

11 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 9/28/20  Rubius Therapeutics, Inc.         8-K:5,9     9/23/20   12:359K                                   Toppan Merrill/FA
 8/10/20  Rubius Therapeutics, Inc.         10-Q        6/30/20   53:5.3M                                   Toppan Merrill Bridge/FA
 5/11/20  Rubius Therapeutics, Inc.         10-Q        3/31/20   53:5M                                     Toppan Merrill Bridge/FA
 3/12/20  Rubius Therapeutics, Inc.         10-K       12/31/19   86:13M                                    Toppan Merrill Bridge/FA
11/14/19  Rubius Therapeutics, Inc.         10-Q        9/30/19   67:7.4M                                   Toppan Merrill Bridge/FA
 8/01/19  Rubius Therapeutics, Inc.         S-3                    7:1.7M                                   Toppan Merrill-FA
 5/15/19  Rubius Therapeutics, Inc.         10-K/A     12/31/18    5:313K                                   Toppan Merrill Bridge/FA
 7/23/18  Rubius Therapeutics, Inc.         8-K:5,8,9   7/17/18    3:223K                                   Toppan Merrill/FA
 7/09/18  Rubius Therapeutics, Inc.         S-1/A                 10:5.6M                                   Toppan Merrill-FA
 7/02/18  Rubius Therapeutics, Inc.         S-1/A                  7:1M                                     Toppan Merrill-FA
 6/22/18  Rubius Therapeutics, Inc.         S-1                   18:11M                                    Toppan Merrill-FA
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