SEC Info - Cryoport, Inc. - ‘10-Q’ for 9/30/23

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Cryoport, Inc. – ‘10-Q’ for 9/30/23 – ‘EX-101.DEF’

On: Thursday, 11/9/23, at 2:18pm ET · For: 9/30/23 · Accession #: 1558370-23-18511 · File #: 1-34632

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/09/23  Cryoport, Inc.                    10-Q        9/30/23   96:10M                                    Toppan Merrill Bridge/FA

Quarterly Report — Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   2.49M 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     33K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     32K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     33K 
10: R1          Document and Entity Information                     HTML     79K 
11: R2          Condensed Consolidated Balance Sheets               HTML    149K 
12: R3          Condensed Consolidated Balance Sheets               HTML     55K 
                (Parenthetical)                                                  
13: R4          Condensed Consolidated Statements of Operations     HTML    125K 
                (Unaudited)                                                      
14: R5          Condensed Consolidated Statements of Comprehensive  HTML     57K 
                Loss (Unaudited)                                                 
15: R6          Condensed Consolidated Statements of Stockholders'  HTML     98K 
                Equity (Unaudited)                                               
16: R7          Condensed Consolidated Statements of Cash Flows     HTML    158K 
                (Unaudited)                                                      
17: R8          Management's Representation and Basis of            HTML     32K 
                Presentation                                                     
18: R9          Nature of the Business                              HTML     30K 
19: R10         Summary of Significant Accounting Policies          HTML     38K 
20: R11         Revenue, Concentrations and Geographic Information  HTML     84K 
21: R12         Net Loss Per Share                                  HTML     76K 
22: R13         Acquisitions                                        HTML     34K 
23: R14         Cash, Cash Equivalents and Short-Term Investments   HTML    159K 
24: R15         Fair Value Measurements                             HTML    161K 
25: R16         Inventory                                           HTML     40K 
26: R17         Goodwill and Intangible Assets                      HTML    136K 
27: R18         Convertible Senior Notes                            HTML     66K 
28: R19         Notes Payable                                       HTML     67K 
29: R20         Leases                                              HTML    110K 
30: R21         Commitments and Contingencies                       HTML     35K 
31: R22         Stockholders' Equity                                HTML     43K 
32: R23         Stock-Based Compensation                            HTML    116K 
33: R24         Subsequent Events                                   HTML     29K 
34: R25         Summary of Significant Accounting Policies          HTML     40K 
                (Policies)                                                       
35: R26         Revenue, Concentrations and Geographic Information  HTML     82K 
                (Tables)                                                         
36: R27         Net Loss Per Share (Tables)                         HTML     77K 
37: R28         Cash, Cash Equivalents and Short-Term Investments   HTML    165K 
                (Tables)                                                         
38: R29         Fair Value Measurements (Tables)                    HTML    159K 
39: R30         Inventory (Tables)                                  HTML     41K 
40: R31         Goodwill and Intangible Assets (Tables)             HTML    142K 
41: R32         Convertible Senior Notes (Tables)                   HTML     62K 
42: R33         Notes Payable (Tables)                              HTML     70K 
43: R34         Leases (Tables)                                     HTML    113K 
44: R35         Stockholders' Equity (Tables)                       HTML     35K 
45: R36         Stock-Based Compensation (Tables)                   HTML    119K 
46: R37         Nature of the Business (Details)                    HTML     31K 
47: R38         Summary of Significant Accounting Policies          HTML     30K 
                (Details)                                                        
48: R39         Revenue, Concentrations and Geographic Information  HTML     53K 
                (Details)                                                        
49: R40         Revenue, Concentrations and Geographic Information  HTML     47K 
                - Disaggregates our revenues by major markets                    
                (Details)                                                        
50: R41         Revenue, Concentrations and Geographic Information  HTML     45K 
                - Disaggregation our geographical revenues by                    
                origin (Details)                                                 
51: R42         Revenue, Concentrations and Geographic Information  HTML     38K 
                - Credit Losses (Details)                                        
52: R43         Net Loss Per Share - Amounts used in computing net  HTML     65K 
                loss per share (Details)                                         
53: R44         Net Loss Per Share - The number of shares excluded  HTML     50K 
                from the computation of diluted loss per share                   
                (Details)                                                        
54: R45         Acquisitions (Details)                              HTML     69K 
55: R46         Acquisitions - 2023 Acquisitions (Details)          HTML     32K 
56: R47         Cash, Cash Equivalents and Short-Term investments   HTML     54K 
                (Details)                                                        
57: R48         Cash, Cash Equivalents and Short-Term Investments   HTML     43K 
                - Available-for-sale Investments (Details)                       
58: R49         Cash, Cash Equivalents and Short-term Investments   HTML     42K 
                - Contractual maturities (Details)                               
59: R50         Cash, Cash Equivalents and Short-Term Investments   HTML     54K 
                - Company's gross unrealized losses and fair value               
                (Details)                                                        
60: R51         Cash, Cash Equivalents and Short-Term Investments   HTML     36K 
                - Equity investments (Details)                                   
61: R52         Fair Value Measurements - Fair value hierarchy      HTML     60K 
                (Details)                                                        
62: R53         Fair Value Measurements - Estimated fair values     HTML     36K 
                and the carrying values (Details)                                
63: R54         Fair Value Measurements - Losses recognized in      HTML     48K 
                earnings and the change in net asset (Details)                   
64: R55         Fair Value Measurements - Additional Information    HTML     35K 
                (Details)                                                        
65: R56         Inventory (Details)                                 HTML     36K 
66: R57         Goodwill and Intangible Assets - Schedule of        HTML     43K 
                goodwill (Details)                                               
67: R58         Goodwill and Intangible Assets - Intangible Assets  HTML     61K 
                (Details)                                                        
68: R59         Goodwill and Intangible Assets - Expected Future    HTML     42K 
                Amortization (Details)                                           
69: R60         Goodwill and Intangible Assets - Additional         HTML     30K 
                Information (Details)                                            
70: R61         Convertible Senior Notes - Components of            HTML     45K 
                Convertible notes payable (Details)                              
71: R62         Convertible Senior Notes - Interest expenses        HTML     44K 
                incurred on Convertible notes payable (Details)                  
72: R63         Convertible Senior Notes - Additional Information   HTML     53K 
                (Details)                                                        
73: R64         Notes Payable (Details)                             HTML     45K 
74: R65         Notes Payable - Interest expense (Details)          HTML     44K 
75: R66         Notes Payable - Future note payments (Details)      HTML     53K 
76: R67         Note Payable - Additional Information (Details)     HTML     44K 
77: R68         Leases - Components Of Lease Cost (Details)         HTML     39K 
78: R69         Leases - Supplemental Cash Flows Information        HTML     53K 
                (Details)                                                        
79: R70         Leases - Future minimum lease payments under        HTML     74K 
                non-cancellable leases (Details)                                 
80: R71         Leases - Additional Information (Details)           HTML     40K 
81: R72         Commitments and Contingencies (Details)             HTML     34K 
82: R73         Stockholders' Equity - Authorized Stock (Details)   HTML     52K 
83: R74         Stockholders' Equity - Repurchase Program           HTML     52K 
                (Details)                                                        
84: R75         Stockholders' Equity - Common Stock Reserved for    HTML     46K 
                Future Issuance (Details)                                        
85: R76         Stock-Based Compensation - Fair value of each       HTML     52K 
                option grant was estimated on the date of grant                  
                using Black-Scholes (Details)                                    
86: R77         Stock-Based Compensation - Total stock-based        HTML     44K 
                compensation expense (Details)                                   
87: R78         Stock-Based Compensation - Stock Option Activity    HTML     81K 
                (Details)                                                        
88: R79         Stock-Based Compensation - Restricted stock unit    HTML     49K 
                (Details)                                                        
89: R80         Stock-Based Compensation - Additional Information   HTML     58K 
                (Details)                                                        
90: R81         Pay vs Performance Disclosure                       HTML     39K 
91: R82         Insider Trading Arrangements                        HTML     33K 
94: XML         IDEA XML File -- Filing Summary                      XML    180K 
92: XML         XBRL Instance -- cyrx-20230930x10q_htm               XML   2.80M 
93: EXCEL       IDEA Workbook of Financial Report Info              XLSX    156K 
 6: EX-101.CAL  XBRL Calculations -- cyrx-20230930_cal               XML    227K 
 7: EX-101.DEF  XBRL Definitions -- cyrx-20230930_def                XML    654K 
 8: EX-101.LAB  XBRL Labels -- cyrx-20230930_lab                     XML   1.47M 
 9: EX-101.PRE  XBRL Presentations -- cyrx-20230930_pre              XML   1.07M 
 5: EX-101.SCH  XBRL Schema -- cyrx-20230930                         XSD    200K 
95: JSON        XBRL Instance as JSON Data -- MetaLinks              574±   873K 
96: ZIP         XBRL Zipped Folder -- 0001558370-23-018511-xbrl      Zip    395K

‘EX-101.DEF’ — XBRL Definitions — cyrx-20230930_def

This Exhibit is an XBRL File.

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<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis" xlink:label="RangeAxis" xlink:title="RangeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember" xlink:label="RangeMember" xlink:title="RangeMember"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="RangeAxis" xlink:to="RangeMember" xlink:title="definition: RangeAxis to RangeMember" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="IncomeStatementLocationAxis" xlink:title="IncomeStatementLocationAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="IncomeStatementLocationDomain" xlink:title="IncomeStatementLocationDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="IncomeStatementLocationAxis" xlink:to="IncomeStatementLocationDomain" xlink:title="definition: IncomeStatementLocationAxis to IncomeStatementLocationDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis" xlink:label="AwardTypeAxis" xlink:title="AwardTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:title="ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="AwardTypeAxis" xlink:to="ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:title="definition: AwardTypeAxis to ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:label="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:title="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:label="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:title="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:to="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:title="definition: ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis to ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="IncomeTaxAuthorityAxis" xlink:title="IncomeTaxAuthorityAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="IncomeTaxAuthorityDomain" xlink:title="IncomeTaxAuthorityDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="IncomeTaxAuthorityAxis" xlink:to="IncomeTaxAuthorityDomain" xlink:title="definition: IncomeTaxAuthorityAxis to IncomeTaxAuthorityDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:title="AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="AntidilutiveSecuritiesNameDomain" xlink:title="AntidilutiveSecuritiesNameDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:to="AntidilutiveSecuritiesNameDomain" xlink:title="definition: AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis to AntidilutiveSecuritiesNameDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="OptionIndexedToIssuersEquityTypeAxis" xlink:title="OptionIndexedToIssuersEquityTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="OptionIndexedToIssuersEquityTypeDomain" xlink:title="OptionIndexedToIssuersEquityTypeDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="OptionIndexedToIssuersEquityTypeAxis" xlink:to="OptionIndexedToIssuersEquityTypeDomain" xlink:title="definition: OptionIndexedToIssuersEquityTypeAxis to OptionIndexedToIssuersEquityTypeDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis" xlink:label="PlanNameAxis" xlink:title="PlanNameAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain" xlink:label="PlanNameDomain" xlink:title="PlanNameDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="PlanNameAxis" xlink:to="PlanNameDomain" xlink:title="definition: PlanNameAxis to PlanNameDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis" xlink:label="StatementGeographicalAxis" xlink:title="StatementGeographicalAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain" xlink:label="SegmentGeographicalDomain" xlink:title="SegmentGeographicalDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="StatementGeographicalAxis" xlink:to="SegmentGeographicalDomain" xlink:title="definition: StatementGeographicalAxis to SegmentGeographicalDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="ConcentrationRiskByBenchmarkAxis" xlink:title="ConcentrationRiskByBenchmarkAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="ConcentrationRiskBenchmarkDomain" xlink:title="ConcentrationRiskBenchmarkDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ConcentrationRiskByBenchmarkAxis" xlink:to="ConcentrationRiskBenchmarkDomain" xlink:title="definition: ConcentrationRiskByBenchmarkAxis to ConcentrationRiskBenchmarkDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MajorCustomersAxis" xlink:label="MajorCustomersAxis" xlink:title="MajorCustomersAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain" xlink:label="NameOfMajorCustomerDomain" xlink:title="NameOfMajorCustomerDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="MajorCustomersAxis" xlink:to="NameOfMajorCustomerDomain" xlink:title="definition: MajorCustomersAxis to NameOfMajorCustomerDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="PropertyPlantAndEquipmentByTypeAxis" xlink:title="PropertyPlantAndEquipmentByTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="PropertyPlantAndEquipmentTypeDomain" xlink:title="PropertyPlantAndEquipmentTypeDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="PropertyPlantAndEquipmentByTypeAxis" xlink:to="PropertyPlantAndEquipmentTypeDomain" xlink:title="definition: PropertyPlantAndEquipmentByTypeAxis to PropertyPlantAndEquipmentTypeDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="FairValueByAssetClassAxis" xlink:title="FairValueByAssetClassAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:title="FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="FairValueByAssetClassAxis" xlink:to="FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:title="definition: FairValueByAssetClassAxis to FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="RelatedPartyTransactionsByRelatedPartyAxis" xlink:title="RelatedPartyTransactionsByRelatedPartyAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain" xlink:label="RelatedPartyDomain" xlink:title="RelatedPartyDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="RelatedPartyDomain" xlink:title="definition: RelatedPartyTransactionsByRelatedPartyAxis to RelatedPartyDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="ConcentrationRiskByTypeAxis" xlink:title="ConcentrationRiskByTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="ConcentrationRiskTypeDomain" xlink:title="ConcentrationRiskTypeDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ConcentrationRiskByTypeAxis" xlink:to="ConcentrationRiskTypeDomain" xlink:title="definition: ConcentrationRiskByTypeAxis to ConcentrationRiskTypeDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementScenarioAxis" xlink:label="StatementScenarioAxis" xlink:title="StatementScenarioAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="ScenarioUnspecifiedDomain" xlink:title="ScenarioUnspecifiedDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="StatementScenarioAxis" xlink:to="ScenarioUnspecifiedDomain" xlink:title="definition: StatementScenarioAxis to ScenarioUnspecifiedDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualAxis" xlink:label="TitleOfIndividualAxis" xlink:title="TitleOfIndividualAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="TitleOfIndividualWithRelationshipToEntityDomain" xlink:title="TitleOfIndividualWithRelationshipToEntityDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="TitleOfIndividualAxis" xlink:to="TitleOfIndividualWithRelationshipToEntityDomain" xlink:title="definition: TitleOfIndividualAxis to TitleOfIndividualWithRelationshipToEntityDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="SubsequentEventTypeAxis" xlink:title="SubsequentEventTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="SubsequentEventTypeDomain" xlink:title="SubsequentEventTypeDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="SubsequentEventTypeAxis" xlink:to="SubsequentEventTypeDomain" xlink:title="definition: SubsequentEventTypeAxis to SubsequentEventTypeDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_PreferredStockRedemptionPeriodAxis" xlink:label="PreferredStockRedemptionPeriodAxis" xlink:title="PreferredStockRedemptionPeriodAxis"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_PreferredStockRedemptionPeriodDomain" xlink:label="PreferredStockRedemptionPeriodDomain" xlink:title="PreferredStockRedemptionPeriodDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="PreferredStockRedemptionPeriodAxis" xlink:to="PreferredStockRedemptionPeriodDomain" xlink:title="definition: PreferredStockRedemptionPeriodAxis to PreferredStockRedemptionPeriodDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_InvestorsAxis" xlink:label="InvestorsAxis" xlink:title="InvestorsAxis"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_InvestorsDomain" xlink:label="InvestorsDomain" xlink:title="InvestorsDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="InvestorsAxis" xlink:to="InvestorsDomain" xlink:title="definition: InvestorsAxis to InvestorsDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_ServicesAxis" xlink:label="ServicesAxis" xlink:title="ServicesAxis"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_ServicesDomain" xlink:label="ServicesDomain" xlink:title="ServicesDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ServicesAxis" xlink:to="ServicesDomain" xlink:title="definition: ServicesAxis to ServicesDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="FinancialInstrumentAxis" xlink:title="FinancialInstrumentAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:title="TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="FinancialInstrumentAxis" xlink:to="TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:title="definition: FinancialInstrumentAxis to TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="TypeOfArrangementAxis" xlink:title="TypeOfArrangementAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="ArrangementsAndNonarrangementTransactionsMember" xlink:title="ArrangementsAndNonarrangementTransactionsMember"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="TypeOfArrangementAxis" xlink:to="ArrangementsAndNonarrangementTransactionsMember" xlink:title="definition: TypeOfArrangementAxis to ArrangementsAndNonarrangementTransactionsMember" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityNameAxis" xlink:label="IncomeTaxAuthorityNameAxis" xlink:title="IncomeTaxAuthorityNameAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityNameDomain" xlink:label="IncomeTaxAuthorityNameDomain" xlink:title="IncomeTaxAuthorityNameDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="IncomeTaxAuthorityNameAxis" xlink:to="IncomeTaxAuthorityNameDomain" xlink:title="definition: IncomeTaxAuthorityNameAxis to IncomeTaxAuthorityNameDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="TaxCreditCarryforwardAxis" xlink:title="TaxCreditCarryforwardAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="TaxCreditCarryforwardNameDomain" xlink:title="TaxCreditCarryforwardNameDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="TaxCreditCarryforwardAxis" xlink:to="TaxCreditCarryforwardNameDomain" xlink:title="definition: TaxCreditCarryforwardAxis to TaxCreditCarryforwardNameDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:label="RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:title="RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:label="RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:title="RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:to="RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:title="definition: RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis to RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_InstallmentsAxis" xlink:label="InstallmentsAxis" xlink:title="InstallmentsAxis"/>

<link:loc xlink:type="locator" xlink:href="cyrx-20230930.xsd#cyrx_InstallmentsDomain" xlink:label="InstallmentsDomain" xlink:title="InstallmentsDomain"/>

<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="InstallmentsAxis" xlink:to="InstallmentsDomain" xlink:title="definition: InstallmentsAxis to InstallmentsDomain" use="optional" order="1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis_1" xlink:title="us-gaap_DebtInstrumentAxis_1"/>

<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1" xlink:title="us-gaap_DebtInstrumentNameDomain_1"/>

<link:definitionArc xlink:type="arc" xlink:from="us-gaap_DebtInstrumentAxis_1" xlink:to="us-gaap_DebtInstrumentNameDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap_DebtInstrumentAxis_1 To us-gaap_DebtInstrumentNameDomain_1" order="1"/>

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3 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

12/21/23  Cryoport, Inc.                    424B3                  1:533K                                   Toppan Merrill/FA
12/15/23  Cryoport, Inc.                    POS AM                 2:866K                                   Toppan Merrill/FA
12/15/23  Cryoport, Inc.                    POSASR     12/15/23    6:967K                                   Toppan Merrill/FA

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Filing Submission 0001558370-23-018511 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Cryoport, Inc. – ‘10-Q’ for 9/30/23 – ‘EX-101.DEF’

On: Thursday, 11/9/23, at 2:18pm ET · For: 9/30/23 · Accession #: 1558370-23-18511 · File #: 1-34632

Previous ‘10-Q’: ‘10-Q’ on 8/9/23 for 6/30/23 · Next & Latest: ‘10-Q’ on 5/8/24 for 3/31/24 · 3 References: By: Cryoport, Inc. – ‘424B3’ on 12/21/23 By: Cryoport, Inc. – ‘POS AM’ on 12/15/23 By: Cryoport, Inc. – ‘POSASR’ on 12/15/23

Quarterly Report — Form 10-QFiling Table of Contents

‘EX-101.DEF’ — XBRL Definitions — cyrx-20230930_def

This Exhibit is an XBRL File.

3 Subsequent Filings that Reference this Filing

Previous ‘10-Q’: ‘10-Q’ on 8/9/23 for 6/30/23 · Next & Latest: ‘10-Q’ on 5/8/24 for 3/31/24 · 3 References:

Quarterly Report — Form 10-Q

Filing Table of Contents