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CASI Pharmaceuticals, Inc. – ‘20-F’ for 12/31/23 – ‘EX-4.46’

On:  Thursday, 3/28/24, at 11:01am ET   ·   For:  12/31/23   ·   Accession #:  1558370-24-4190   ·   File #:  1-41666

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/28/24  CASI Pharmaceuticals, Inc.        20-F       12/31/23  142:21M                                    Toppan Merrill Bridge/FA

Annual or Annual-Transition Report by a Foreign Non-Canadian Issuer   —   Form 20-F   —   SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 20-F        Annual or Annual-Transition Report by a Foreign     HTML   3.52M 
                Non-Canadian Issuer                                              
 2: EX-1.1      Underwriting Agreement or Conflict Minerals Report  HTML   1.36M 
 3: EX-2.1      Plan of Acquisition, Reorganization, Arrangement,   HTML     58K 
                Liquidation or Succession                                        
 4: EX-4.29     Instrument Defining the Rights of Security Holders  HTML    230K 
 5: EX-4.37     Instrument Defining the Rights of Security Holders  HTML   1.10M 
 6: EX-4.38     Instrument Defining the Rights of Security Holders  HTML    321K 
 7: EX-4.39     Instrument Defining the Rights of Security Holders  HTML     56K 
 8: EX-4.40     Instrument Defining the Rights of Security Holders  HTML    336K 
 9: EX-4.41     Instrument Defining the Rights of Security Holders  HTML    315K 
10: EX-4.42     Instrument Defining the Rights of Security Holders  HTML    140K 
11: EX-4.43     Instrument Defining the Rights of Security Holders  HTML    128K 
12: EX-4.44     Instrument Defining the Rights of Security Holders  HTML    121K 
13: EX-4.45     Instrument Defining the Rights of Security Holders  HTML    314K 
14: EX-4.46     Instrument Defining the Rights of Security Holders  HTML     92K 
15: EX-4.47     Instrument Defining the Rights of Security Holders  HTML    122K 
16: EX-4.48     Instrument Defining the Rights of Security Holders  HTML     60K 
17: EX-8.1      Opinion of Counsel re: Tax Matters                  HTML     38K 
21: EX-13.1     Annual or Quarterly Report to Security Holders      HTML     41K 
22: EX-13.2     Annual or Quarterly Report to Security Holders      HTML     41K 
24: EX-97.1     Clawback Policy re: Recovery of Erroneously         HTML     62K 
                Awarded Compensation                                             
18: EX-11.1     Statement re: the Computation of Earnings Per       HTML     67K 
                Share                                                            
19: EX-12.1     Statement re: the Computation of Ratios             HTML     44K 
20: EX-12.2     Statement re: the Computation of Ratios             HTML     44K 
23: EX-15.1     Letter re: Unaudited Interim Financial Info         HTML     38K 
30: R1          Document and Entity Information                     HTML    115K 
31: R2          Consolidated Balance Sheets                         HTML    147K 
32: R3          Consolidated Balance Sheets (Parenthetical)         HTML     50K 
33: R4          Consolidated Statements of Operations and           HTML    185K 
                Comprehensive Loss                                               
34: R5          Consolidated Statements of Stockholders' Equity     HTML     90K 
35: R6          Consolidated Statements of Cash Flows               HTML    188K 
36: R7          Description of Business                             HTML     87K 
37: R8          Summary of Significant Accounting Policies          HTML     96K 
38: R9          Investment in Equity Securities, at Fair Value and  HTML    187K 
                Long-Term Investments                                            
39: R10         Inventories                                         HTML     41K 
40: R11         Leases                                              HTML     89K 
41: R12         Property, Plant and Equipment                       HTML     61K 
42: R13         Intangible Assets                                   HTML    111K 
43: R14         Accrued and Other Current Liabilities, and Other    HTML     76K 
                Liabilities                                                      
44: R15         Short Term Borrowings                               HTML     43K 
45: R16         Notes Payable                                       HTML     45K 
46: R17         Grants                                              HTML     42K 
47: R18         Redeemable Noncontrolling Interest and Long Term    HTML     68K 
                Borrowing                                                        
48: R19         Shareholders' Equity                                HTML     66K 
49: R20         Costs of Revenues                                   HTML     40K 
50: R21         Net Loss Per Share                                  HTML     65K 
51: R22         Employee Benefit Plan                               HTML     42K 
52: R23         Share-Based Compensation                            HTML    182K 
53: R24         Income Taxes                                        HTML    159K 
54: R25         Fair Value Measurements                             HTML    118K 
55: R26         Related Party Transactions                          HTML     48K 
56: R27         Commitments and Contingencies                       HTML     44K 
57: R28         Restricted Net Assets                               HTML     41K 
58: R29         Subsequent Events                                   HTML     41K 
59: R30         Condensed Financial Information of Registrant       HTML    220K 
60: R31         Summary of Significant Accounting Policies          HTML    164K 
                (Policies)                                                       
61: R32         Summary of Significant Accounting Policies          HTML     50K 
                (Tables)                                                         
62: R33         Investment in Equity Securities, at Fair Value and  HTML    170K 
                Long-Term Investments (Tables)                                   
63: R34         Leases (Tables)                                     HTML     88K 
64: R35         Property, Plant and Equipment (Tables)              HTML     57K 
65: R36         Intangible Assets (Tables)                          HTML    111K 
66: R37         Accrued and Other Current Liabilities, and Other    HTML     76K 
                Liabilities (Tables)                                             
67: R38         Redeemable Noncontrolling Interest (Tables)         HTML     61K 
68: R39         Shareholders' Equity (Tables)                       HTML     53K 
69: R40         Net Loss Per Share (Tables)                         HTML     64K 
70: R41         Share-Based Compensation (Tables)                   HTML    180K 
71: R42         Income Taxes (Tables)                               HTML    159K 
72: R43         Fair Value Measurements (Tables)                    HTML    117K 
73: R44         Condensed Financial Information of Registrant       HTML    222K 
                (Tables)                                                         
74: R45         DESCRIPTION OF BUSINESS - Liquidity and Capital     HTML    111K 
                Resources (Details)                                              
75: R46         DESCRIPTION OF BUSINESS - License and Distribution  HTML     51K 
                Agreements (China Resources Pharmaceutical                       
                Commercial Group International Trading Co., Ltd.)                
                (Details)                                                        
76: R47         DESCRIPTION OF BUSINESS - License and Distribution  HTML     50K 
                Agreements (Precision Autoimmune Therapeutics Co.,               
                Ltd) (Details)                                                   
77: R48         DESCRIPTION OF BUSINESS - License and Distribution  HTML     47K 
                Agreements (Juventas Cell Therapy Ltd.) (Details)                
78: R49         DESCRIPTION OF BUSINESS - License and Distribution  HTML     72K 
                Agreements (BioInvent International AB) (Details)                
79: R50         DESCRIPTION OF BUSINESS - License and Distribution  HTML     54K 
                Agreements (Black Belt Therapeutics Limited)                     
                (Details)                                                        
80: R51         DESCRIPTION OF BUSINESS - License and Distribution  HTML     56K 
                Agreements (Cleave Therapeutics, Inc.) (Details)                 
81: R52         DESCRIPTION OF BUSINESS - License and Distribution  HTML     48K 
                Agreements (Pharmathen Global BV) (Details)                      
82: R53         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     41K 
                Consolidation (Details)                                          
83: R54         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     40K 
                Segment Reporting (Details)                                      
84: R55         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Cash   HTML     47K 
                and Cash Equivalents (Details)                                   
85: R56         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     46K 
                Aggregate Cost And Fair Value (Details)                          
86: R57         Summary of Significant Accounting Policies - Ppe    HTML     48K 
                (Details)                                                        
87: R58         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     66K 
                LONG-TERM INVESTMENTS - Investment in equity                     
                securities, at fair value-MaxCyte Inc. (Details)                 
88: R59         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     94K 
                LONG-TERM INVESTMENTS - Investment in equity                     
                securities, at fair value-BioInvent International                
                AB ordinary shares and warrants (Details)                        
89: R60         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     71K 
                LONG-TERM INVESTMENTS - BioInvent International AB               
                - Summary of Investments (Details)                               
90: R61         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     66K 
                LONG-TERM INVESTMENTS - Summary of Long-term                     
                investments (Details)                                            
91: R62         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     86K 
                LONG-TERM INVESTMENTS - Investment in equity                     
                securities, at fair value-Juventas Cell Therapy                  
                Ltd. (Details)                                                   
92: R63         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     89K 
                LONG-TERM INVESTMENTS - Investment in equity                     
                securities, at fair value-Alesta Therapeutics B.V.               
                (Details)                                                        
93: R64         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     78K 
                LONG-TERM INVESTMENTS - Investment in equity                     
                securities, at fair value-Cleave Therapeutics,                   
                Inc. (Details)                                                   
94: R65         INVESTMENT IN EQUITY SECURITIES, AT FAIR VALUE AND  HTML     75K 
                LONG-TERM INVESTMENTS - Investment in Precision                  
                Autoimmune Therapeutics Co Ltd (Pat) (Details)                   
95: R66         Inventories (Details)                               HTML     43K 
96: R67         Leases - (Details)                                  HTML     57K 
97: R68         Leases - Right of Use Assets and Liabilities        HTML     51K 
                (Details)                                                        
98: R69         LEASES - Supplemental Cash Flow (Details)           HTML     45K 
99: R70         LEASES - Future Undiscounted Cash Flows (Details)   HTML     61K 
100: R71         PROPERTY, PLANT AND EQUIPMENT - Narratives          HTML     50K  
                (Details)                                                        
101: R72         PROPERTY, PLANT AND EQUIPMENT - By type (Details)   HTML     55K  
102: R73         INTANGIBLE ASSETS - Narratives (Details)            HTML     72K  
103: R74         INTANGIBLE ASSETS - Net Definite-lived Intangible   HTML     59K  
                Assets (Details)                                                 
104: R75         INTANGIBLE ASSETS - Intangible Assets Rollforward   HTML     50K  
                (Details)                                                        
105: R76         INTANGIBLE ASSETS - Expected Future Amortization    HTML     52K  
                Expense (Details)                                                
106: R77         Accrued and Other Current Liabilities, and Other    HTML     73K  
                Liabilities (Details)                                            
107: R78         Short Term Borrowings (Details)                     HTML     63K  
108: R79         Notes Payable (Details)                             HTML     50K  
109: R80         Grants (Details)                                    HTML     51K  
110: R81         Redeemable Noncontrolling Interest and Long Term    HTML     96K  
                Borrowing (Details)                                              
111: R82         Redeemable Noncontrolling Interest and Long Term    HTML     51K  
                Borrowing - Changes in Redeemable Noncontrolling                 
                Interest (Details)                                               
112: R83         Shareholders' Equity (Details)                      HTML     83K  
113: R84         Shareholders' Equity - Warrants Activity (Details)  HTML     52K  
114: R85         Costs of Revenues (Details)                         HTML     42K  
115: R86         Net Loss Per Share (Details)                        HTML     43K  
116: R87         Net Loss Per Share - Basic and diluted net loss     HTML     70K  
                per share computation (Details)                                  
117: R88         Employee Benefit Plan (Details)                     HTML     44K  
118: R89         SHARE-BASED COMPENSATION - Compensation Expense     HTML     55K  
                (Details)                                                        
119: R90         SHARE-BASED COMPENSATION - Weighted-Average         HTML     55K  
                Assumptions (Details)                                            
120: R91         SHARE-BASED COMPENSATION - Options Outstanding      HTML     95K  
                (Details)                                                        
121: R92         SHARE-BASED COMPENSATION - Stock Option             HTML     70K  
                Outstanding (Details)                                            
122: R93         Share-Based Compensation (Details)                  HTML     86K  
123: R94         INCOME TAXES - Loss Before Income Taxes (Details)   HTML     50K  
124: R95         INCOME TAXES - Deferred Income Tax Assets And       HTML     72K  
                Liabilities (Details)                                            
125: R96         INCOME TAXES - Reconciliation Of The Provision For  HTML     65K  
                Income Taxes (Details)                                           
126: R97         INCOME TAXES - Valuation allowance (Details)        HTML     47K  
127: R98         INCOME TAXES - Gross Unrecognized Tax Benefits      HTML     45K  
                (Details)                                                        
128: R99         Income Taxes (Details)                              HTML     77K  
129: R100        FAIR VALUE MEASUREMENTS - Financial and             HTML     67K  
                Non-Financial Assets and Liabilities (Details)                   
130: R101        FAIR VALUE MEASUREMENTS - Quantitative Information  HTML     50K  
                about Level 3 Fair Value Measurements (Details)                  
131: R102        Fair Value Measurements (Details)                   HTML     62K  
132: R103        Related Party Transactions (Details)                HTML     83K  
133: R104        Commitments and Contingencies (Details)             HTML     58K  
134: R105        Restricted Net Assets (Details)                     HTML     40K  
135: R106        CONDENSED FINANCIAL INFORMATION OF REGISTRANT -     HTML    150K  
                Condensed Balance Sheets (Details)                               
136: R107        CONDENSED FINANCIAL INFORMATION OF REGISTRANT -     HTML    108K  
                Condensed Statements of Operations and                           
                Comprehensive Loss (Details)                                     
137: R108        CONDENSED FINANCIAL INFORMATION OF REGISTRANT -     HTML    108K  
                Condensed Statements of Cash Flows (Details)                     
139: XML         IDEA XML File -- Filing Summary                      XML    243K  
142: XML         XBRL Instance -- casi-20231231x20f_htm               XML   3.57M  
138: EXCEL       IDEA Workbook of Financial Report Info              XLSX    249K  
26: EX-101.CAL  XBRL Calculations -- casi-20231231_cal               XML    267K 
27: EX-101.DEF  XBRL Definitions -- casi-20231231_def                XML   1.32M 
28: EX-101.LAB  XBRL Labels -- casi-20231231_lab                     XML   1.83M 
29: EX-101.PRE  XBRL Presentations -- casi-20231231_pre              XML   1.74M 
25: EX-101.SCH  XBRL Schema -- casi-20231231                         XSD    324K 
140: JSON        XBRL Instance as JSON Data -- MetaLinks              668±  1.06M  
141: ZIP         XBRL Zipped Folder -- 0001558370-24-004190-xbrl      Zip   1.32M  


‘EX-4.46’   —   Instrument Defining the Rights of Security Holders


This Exhibit is an HTML Document rendered as filed.  [ Alternative Formats ]



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  机密 签署稿 2013年[]月  

Exhibit 4.46

Information in this exhibit identified by brackets and *** has been redacted because it is not material and is the type that the company treats as private or confidential

Guarantee Contract

This Guarantee Contract (this “Contract”) is entered into this 14th day of December 2023 in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

Guarantor: CASI Pharmaceuticals, Inc. (“CASI Cayman” or “Guarantor”) a Cayman Islands company limited by shares, having its registered office at the offices of Maples Corporate Services Limited, PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands, with its person-in-charge [***];

Creditor: Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership) (“HCYD” or “Creditor” or “Master Contract Creditor”), a limited partnership duly organized and validly existing under the laws of China, with a unified social credit code of [***], having its registered office at Suite 1906-3, North Block, 5 Zhihui Road, Huishan Economic Development Zone, Wuxi, and with its executive partner [***];  and

Debtor: CASI Pharmaceuticals (Wuxi) Co., Ltd. (“CASI Wuxi” or “Debtor” or “Master Contract Debtor”), a limited liability company duly organized and validly existing under the laws of China, with a unified social credit code of [***], having its registered office at 1719-15 Huishan Avenue, Huishan Economic Development Zone, Wuxi, and with its legal representative [***],

hereinafter collectively referred to as the “Parties” and individually as a “Party”. When referring to one another, they are referred to as a “Party” or the “other Parties”, as the context requires.

WHEREAS:

1.HCYD, on the one hand, and CASI Wuxi, CASI Cayman and CASI Pharmaceuticals (China) Co., Ltd., on the other hand, entered into that certain Convertible Loan Investment Agreement in Respect of CASI Pharmaceuticals (Wuxi) Co., Ltd. (“Convertible Loan Investment Agreement” or “Master Contract”), dated as of December 14, 2023, under which HCYD intends to provide a convertible loan of RMB [***] to CASI Wuxi as an investment in the latter.
2.In order to ensure the effective performance of the Convertible Loan Investment Agreement, CASI Cayman, the controlling shareholder of CASI Wuxi, agrees to provide an irrevocable joint and several guarantee, as per the terms and conditions set forth herein, for all indebtedness, obligations and liabilities owed by CASI Wuxi to HCYD under the Convertible Loan Investment Agreement.

NOW, THEREFORE, the Parties hereto enter into, and intend to be bound by, this Contract after agreeing upon the following terms and conditions through equal negotiation, in accordance with the provisions of the Civil Code of the People’s Republic of China and other applicable laws and regulations, in order to clarify the rights and obligations of the Parties hereto.


Article IDefinitions and Interpretation

For the purpose of this Contract, unless otherwise expressly provided herein or the context otherwise requires, the following terms shall have the following meanings:

1.1“CASI Cayman” or “Guarantor”: shall mean CASI Pharmaceuticals, Inc.
1.2“HCYD”, “Creditor” or “Master Contract Creditor”: shall mean Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership).
1.3“CASI Wuxi”, “Debtor” or “Master Contract Debtor”: shall  mean CASI Pharmaceuticals (Wuxi) Co., Ltd.
1.4“Master Contract or “Convertible Loan Investment Agreement”: shall mean the Convertible Loan Investment Agreement in Respect of CASI Pharmaceuticals (Wuxi) Co., Ltd. between HCYD, on the one hand, and CASI Wuxi, CASI Cayman and CASI Pharmaceuticals (China) Co., Ltd., on the other hand, dated as of December 14, 2023, together with all annexes, supplemental agreements and any supplements and/or amendments thereto.
1.5“China”: means, for the purpose of this Contract, the mainland of the People’s Republic of China, excluding the Hong Kong Special Administrative Region, the Macau Special Administrative Region and Taiwan region.
Article IIType of Guarantee

The guarantee provided by the Guarantor hereunder is an irrevocable joint and several guarantee.

Article IIIType and Amount of the Main Debts Guaranteed

The main debts guaranteed hereunder comprise an investment of RMB [***]  made by HCYD in CASI Wuxi by way of convertible loan, and all other indebtedness, obligations and liabilities of CASI Wuxi under the Master Contract.

Article IVScope of Guarantee
4.1The guarantee covers the principal of the convertible loan investment set forth in Article III hereof, interest, default interest, late payment fees, liquidated damages, damages, and other amounts payable by the Master Contract Debtor to the Master Contract Creditor, as well as the costs and expenses (including but not limited to disposal costs, taxes, litigation costs, arbitration fees, property preservation fees, preservation guarantee fees and insurance premiums, travel expenses, attorney’s fees, execution fees, appraisal fees, auction fees, notary fees, service fees, public notice fees and mailing fees) incurred by the Master Contract Creditor to recover the amounts owed to it.

4.2Even if the Master Contract and its amendments or supplements are, in whole or in part, not formed, inoperative, invalid, revoked, rescinded or objectively impossible to fulfill, the Guarantor shall still, within the scope of guarantee agreed herein, provide the guarantee for the indebtedness arising from the return of property or the compensation for losses, until the date when such losses have been fully satisfied.
4.3If the Master Contract Creditor and the Debtor agree, through negotiation, to make any amendments or supplements to any provisions of the Master Contract, the Guarantor hereby agrees that it shall provide a guarantee for any indebtedness under the Master Contract after such amendments and supplements.
Article VGuarantee Period
5.1The guarantee period shall be [***]  years from the date when the term of performance of the Debtor’s debt obligations under the Master Contract expires. Where the Master Contract Creditor and the Master Contract Debtor conclude a contract to change the term during which the debt obligations under the Master Contract shall be fulfilled, the guarantee period shall be [***] years from the date when such new term of performance of the debt obligations under the Master Contract as agreed upon by the Master Contract Creditor and the Master Contract Debtor expires. If the Master Contract Creditor declares early maturity of the main debts, the guarantee period shall be [***]  years from the date of such early maturity of the main debts as required by the Master Contract Creditor.
5.2The period of time during which the Master Contract Debtor shall fulfill its debt obligations shall be subject to the provisions of the Master Contract.
5.3The terms “maturity”, “expires”, “expire” and “expiration” referred to herein shall include any early maturity declared by the Master Contract Creditor. Where the Master Contract Creditor declares early maturity of the main debts, the early maturity date it declares shall be the date when the term of performance of debt obligations shall expire. When the Master Contract Debtor and the Master Contract Creditor conclude an extension contract with respect to the term of performance of the debt obligations, such term shall be extended accordingly.
Article VIGuarantee Obligations
6.1In the event that the debts under the Master Contract expire or the Master Contract Creditor declares early maturity of the debts according to the provisions of the Master Contract or the applicable laws, if the Master Contract Debtor fails to repay its debts in full as scheduled, or if the Master Contract Debtor violates other provisions of the Master Contract, the Guarantor shall immediately undertake its joint and several liability within the scope of guarantee.
6.2The payments received by the Creditor hereunder shall be used to satisfy the debts owed to it in the following sequence:

(1)Costs and expenses incurred to recover the amounts owed to it and realize its guarantee interests;
(2)Damages;
(3)Late payment fees and liquidated damages;
(4)Interest, default interest and penalty interest; and
(5)Principal of the convertible loan investment.

The Creditor shall have the right to change the above sequence.

6.3The guarantee obligations of the Guarantor hereunder shall not be reduced or discharged, the Master Contract Creditor may directly request the Guarantor to assume its guarantee obligations within the scope of guarantee in accordance with the provisions of this Contract, and the Guarantor hereby expressly waives any and all defenses and objections thereto, regardless of whether there is any other security (whether in the form of, including but not limited to, guarantees, mortgages, pledges or bank guarantees) in respect of the debts owed to the Master Contract Creditor that are guaranteed hereunder, regardless of when such other security is created, whether they are valid, whether they are provided by the Master Contract Debtor itself and whether the Master Contract Creditor makes claims against the other guarantor, and regardless of whether any third parties have agreed to assume the debts hereunder, in whole or in part.
6.4The obligations of the Guarantor hereunder shall not be reduced or discharged, and the Guarantor undertakes that it shall assume its obligations in accordance with the provisions of this Contract, regardless of whether the Creditor has, will or may waive (including but not limited to waiving the mortgages, pledges or other security interests, and waiving the priority thereof), alter (including but not limited to altering the priority, guarantee amount or scope of the mortgages, pledges or other security interests), or reduce or release any mortgages, pledges, guarantees or other forms of security that have been, will or may be provided by the Debtor or any third parties.
6.5The Guarantor agrees that even if certain part of the debts under the Master Contract has been extinguished as a result of the Debtor’s repayment or the Creditor realizing other security interests or for any other reasons, it shall still be liable, within the scope of guarantee hereunder, for the guarantee obligations with respect to the remaining part of the debts that have not been extinguished, in accordance with the provisions hereof.
6.6The Guarantor undertakes that, if the debts under the Master Contract are still not satisfied in their entirety after the Guarantor has fulfilled its guarantee obligations, its claim of the right of subrogation or recovery (including its exercise thereof beforehand) against the Debtor or the other guarantor, shall not, in any way, prejudice the interests of the Creditor, and agrees that the satisfaction of the debts owed under the Master Contract shall have priority over the realization of its right of subrogation or recovery

. Specifically, until the Creditor’s debts have been fully satisfied:
(1)The Guarantor agrees that it will not claim the right of subrogation or recovery against the Debtor or the other guarantor, and that if, for any reason whatsoever, it has realized such right, the amount of money it receives will be used first to satisfy the outstanding debts owed to the Creditor; and
(2)The Guarantor agrees that if there is any real security to secure the debts owed under the Master Contract, it shall not, on the ground of subrogation or for whatever other reasons, claim such collateral or the proceeds from any disposal thereof, and such collateral and proceeds shall be used first to satisfy the outstanding debts owed to the Creditor.
6.7In the event that the Creditor transfers or assigns its rights with respect to the main debts to a third party during the guarantee period in accordance with the law, the Guarantor shall continue to assume its guarantee obligations within the scope of the original guarantee.
6.8In case the Debtor fails to fulfill its debt obligations, the Creditor shall have the right to directly request either of the guarantors to fulfill its guarantee obligations, regardless of whether the Creditor has other forms of security in respect of the debts owed under the Master Contract.
6.9The Creditor may request the Guarantor in advance to satisfy its joint and several liability immediately within the scope of guarantee if:
(1)The Guarantor refuses to perform any obligations agreed herein in breach of any provisions of this Contract;
(2)The Guarantor changes its domicile, receives an administrative or criminal penalty, is involved in a major civil dispute, has a deteriorated financial condition, or, for whatever reason, loses or might lose its capacity to provide the guarantee, thus imposing an adverse effect on its ability to fulfill its guarantee obligations;
(3)The Guarantor becomes bankrupt, is closed temporarily, is filed a petition for reorganization bankruptcy or revoked, or its business license is revoked;
(4)The Guarantor, CASI Cayman, loses its position as the controlling shareholder of, or its actual control over, CASI Wuxi; or
(5)Other circumstances arise that make it difficult or impossible to recover the debts owed to the Creditor under the Master Contract.
6.10This Contract is independent of, and shall survive the invalidity of, the Master Contract. In case the Master Contract becomes invalid, the Guarantor shall be jointly and severally liable for satisfying any indebtedness resulting from the Debtor’s repayment of the principal and interest of the main debts and from the latter’s compensation for losses.

Article VIIOther Obligations of the Guarantor
7.1The Guarantor shall oversee the use (including purposes) of the convertible loan investment funds by the Debtor.
7.2During the guarantee period, without the prior written consent of the Creditor, the Guarantor shall not further provide any mortgages, pledges, guarantees or other forms of security to any third party.
7.3The Guarantor shall inform the Creditor immediately in writing, and shall, as requested by the Creditor, ensure the assumption, transfer or succession of the guarantee obligations hereunder or provide new guarantees acceptable to the Creditor for the performance hereof, if it changes its domicile, receives an administrative or criminal penalty, is involved in a major civil dispute, has a deteriorated financial condition, is closed temporarily, dissolved, ordered to cease its operations pending correction, revoked, or ordered to have its business license revoked, files or is filed a petition for a declaration of bankruptcy, or, for whatever reason, loses or might lose its capacity to provide the guarantee.
7.4In the event of a merger, demerger, change of shareholding, capital increase or reduction, joint venture or consortium of a business of which the Guarantor is the controlling shareholder or actual controller, the Guarantor shall inform the Creditor in a timely manner, and its guarantee obligations shall not be reduced or discharged as a result thereof.
7.5The Guarantor undertakes that its position as the controlling shareholder of, and its actual control over, CASI Wuxi will remain unchanged.
Article VIIIRepresentations and Warranties of the Guarantor
8.1The Guarantor has full capacity to independently enjoy civil rights and assume civil duties, as well as to independently perform civil acts. In accordance with national laws and regulations, it has the capacity to act as a guarantor to provide guarantees to external entities.
8.2The execution and performance hereof are the expression of the true intent of the Guarantor, and have obtained all consents, approvals and authorizations required, free from any legal defects.
8.3The Guarantor has lawful property and sources of income, and has sufficient ability to assume its guarantee obligations. It has no loan defaults, interest on arrears, evasion of debts or other bad credit history, and no criminal records; and no orders, changes in financial status, or agreements with any entities or individuals shall reduce or discharge its guarantee obligations.
8.4The Guarantor is aware of and agrees to all the provisions of the Master Contract, and its provision of the guarantee for the Debtor is entirely voluntary. All the intents expressed hereunder are true and genuine.
8.5All the documents, materials and information provided by the Guarantor to

the Creditor during the execution and performance hereof are true, accurate, complete and valid.
8.6The Guarantor provides true information on its financial status (including but not limited to real estate, equity, bank deposits, and bonds), and, as requested by the Creditor, on its property, financial condition, liabilities, security, and any economic disputes with others. During the guarantee period, the Guarantor willingly agrees to allow the Creditor to conduct inquiries and investigations into its property and financial status.
Article IXPreservation of Rights

The rights granted to the Creditor hereunder shall be without prejudice to and in addition to any rights to which it is entitled under laws, regulations or other contracts. No indulgence, grace, concession, or postponement of the exercise of any rights hereunder, given by the Creditor to the Guarantor in respect of any breach or delay shall be deemed to be a waiver of any right or interest hereunder, or permission or acceptance of any breach hereof, or restrict, prevent or preclude any further exercise of such right or any of its other rights, nor shall it result in the Creditor assuming any obligations or liabilities to the Guarantor.

Article XLiability for Breach
10.1In case the Guarantor breaches any provision hereof or there are any falsehoods, errors or omissions in any representations and warranties hereunder, the Creditor shall have the right to take one or more of the following measures:
(1)Declare early maturity of the main debts;
(2)Require the Guarantor to fulfill its joint and several guarantee obligations;
(3)Require the Guarantor to correct its breaches within the specified period of time;
(4)Require the Guarantor to provide a new guarantee;
(5)Require the Guarantor to compensate the Creditor for all losses suffered (including but not limited to the costs of realizing its guarantee interests, litigation costs, attorney’s fees and other dispute resolution costs and expenses); and/or
(6)Other remedies allowed by laws and regulations.
10.2Where this Contract is invalidated through no fault of the Creditor, the Guarantor shall compensate the Creditor for all the losses incurred, within the scope of guarantee agreed herein.

Article XIApplicable Law and Dispute Resolution
11.1The formation, validity, interpretation, performance and dispute resolution of this Contract shall be governed by, and this Contract shall be construed in accordance with, the laws of the People’s Republic of China (excluding, for the purpose of this Agreement, the laws of the Hong Kong Special Administrative Region, the Macau Special Administrative Region and Taiwan region).
11.2The Parties hereto agree that any dispute or controversy arising out of or in connection with the execution or performance hereof shall be resolved through negotiation. If such negotiation fails, any Party shall have the right to file a lawsuit with the competent people’s court where the Creditor is domiciled. The Parties shall continue to perform the provisions that are not in dispute pending the dispute resolution process.
Article XIIAmendments
12.1The provisions hereof may be amended in writing by unanimous agreement of the Parties hereto.
12.2Anything not addressed herein shall be determined in supplemental agreements among the Parties hereto.
12.3Any provision amended or any supplemental contract shall have the same legal force and effect as this Contract, and in case of any conflict between such provision amended or supplemental contract and this Contract, such provision and supplemental contract shall prevail.
Article XIIINotice and Delivery
13.1Any notice or written communication to be given by any Party to the other Parties hereunder, including but not limited to any and all written documents and notices required to be given hereunder, shall be given by hand, by registered or certified mail, by facsimile or by other means of communication. Such documents and notices shall be deemed to have been delivered and received: if by hand, on the date on which such documents or notices have been delivered to the addresses of the recipients; if by registered or certified mail, on the [***]  day after the mailing of such documents or notices; or if by facsimile, on the date shown on the confirmation of transmission. The designated contact information of each Party is as follows:

If to Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership):

Contact: [***]

Address: [***]

Phone: [***]


Email: [***]

If to CASI Pharmaceuticals, Inc.:

Contact: [***]

Address: [***]

Phone: [***]

Email: [***]

If to CASI Pharmaceuticals (Wuxi) Co., Ltd.:

Contact: [***]

Address: [***]

Phone: [***]

Email: [***]

13.2If any of the contact information of any Party above changes, such Party shall notify the other Parties in writing of the changed contact information pursuant to the provisions of this clause within [***]  days of such change. All notices, documents and applications under this clause shall thereafter be delivered to such changed contact information. If the other Parties have not been notified promptly in writing, the notices, documents and applications they have delivered to the contact information set forth herein shall be deemed to have been delivered. The contact information set forth in this clause shall apply to the service of legal process with respect to any litigation or arbitration proceedings arising out of this Contract or its amendments or supplemental contracts.
Article XIVMiscellaneous
14.1The invalidity or unenforceability of any provision hereof shall not affect the validity and enforceability of the other provisions or the validity of the Contract as a whole.
14.2This Contract shall become effective upon the date on which both of the Guarantor and the Creditor have affixed their common seals to, and their respective legal representative/person-in-charge/authorized representative of the executive partner has signed, the Contract.
14.3This Contract shall be made in four (4) originals, with the Creditor holding two (2) thereof and each of the Guarantor and the Debtor holding one (1) thereof, each of which shall have the same legal force and effect.

(Remainder of Page Intentionally Left Blank – Signature Page Follows)


(Page Intentionally Left Blank - Signature Page to the Guarantee Contract among CASI Pharmaceuticals, Inc., Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership) and CASI Pharmaceuticals (Wuxi) Co., Ltd. Follows.)

IN WITNESS WHEREOF, this Contract has been executed by the authorized representatives of the Parties as of the date first above written.

SIGNED by: [***]

Guarantor: CASI Pharmaceuticals, Inc. (seal)

Person-in-charge (signature): [***]

Creditor: Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership) (seal)

Authorized representative of the executive partner (signature): [***]

Debtor: CASI Pharmaceuticals (Wuxi) Co., Ltd. (seal)

Legal representative (signature): [***]



Dates Referenced Herein

This ‘20-F’ Filing    Date    Other Filings
Filed on:3/28/24None on these Dates
For Period end:12/31/23
12/14/23
 List all Filings 


14 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 5/23/23  CASI Pharmaceuticals, Inc.        S-8 POS     5/23/23    3:156K                                   Toppan Merrill/FA
 4/26/23  CASI Pharmaceuticals, Inc.        20-F       12/31/22  129:16M                                    Toppan Merrill Bridge/FA
 1/31/23  CASI Pharmaceuticals, Inc.        F-4                   22:2.7M                                   Toppan Merrill/FA
11/14/22  CASI Pharmaceuticals, Inc. (DE)   10-Q        9/30/22   74:7.2M                                   Toppan Merrill Bridge/FA
 8/12/22  CASI Pharmaceuticals, Inc. (DE)   10-Q        6/30/22   76:8.1M                                   Toppan Merrill Bridge/FA
12/10/21  CASI Pharmaceuticals, Inc. (DE)   8-K:5,9    12/08/21   12:219K                                   Toppan Merrill/FA
 3/30/21  CASI Pharmaceuticals, Inc. (DE)   10-K       12/31/20  109:13M                                    Toppan Merrill Bridge/FA
11/09/20  CASI Pharmaceuticals, Inc. (DE)   10-Q        9/30/20   91:7.2M                                   Toppan Merrill/FA
 3/16/20  CASI Pharmaceuticals, Inc. (DE)   10-K       12/31/19   98:6.9M                                   Toppan Merrill/FA
 8/09/19  CASI Pharmaceuticals, Inc. (DE)   10-Q        6/30/19   75:16M                                    Toppan Merrill/FA
 5/15/19  CASI Pharmaceuticals, Inc. (DE)   10-Q        3/31/19   78:5.6M                                   Toppan Merrill/FA
 3/29/19  CASI Pharmaceuticals, Inc. (DE)   10-K       12/31/18   91:7.7M                                   Toppan Merrill/FA
 8/14/17  CASI Pharmaceuticals, Inc. (DE)   10-Q        6/30/17   40:1.7M                                   Toppan Merrill/FA
 4/17/07  CASI Pharmaceuticals, Inc.        8-K:5,8,9   4/16/07    9:152K                                   Bowne - DC/FA
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