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| | <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_mdxg_OperatingLeaseRightofuseAssetAmortization_1ec97439-09f4-4ba3-948e-27e27fed2332" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_271af5f5-8883-438c-8b88-3aeba09f5ed9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/> |
| | <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_271af5f5-8883-438c-8b88-3aeba09f5ed9" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_11be3896-59ac-4723-bbfc-09ec0148a848" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/> |
| | <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_ShareBasedCompensation_11be3896-59ac-4723-bbfc-09ec0148a848" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_59003f39-edd5-4395-8b92-271c26cc038c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/> |
| | <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_59003f39-edd5-4395-8b92-271c26cc038c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_f12776df-55ab-4b90-a2ed-be94f9ee805d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/> |
| | <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_f12776df-55ab-4b90-a2ed-be94f9ee805d" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ee0be04a-4dec-4628-96cd-46f7430cb0a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/> |
| | <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_NetIncomeLoss_ee0be04a-4dec-4628-96cd-46f7430cb0a6" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_e28a7c83-13d4-434b-8a09-5aa5a93df46f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation"/> |
| | <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_Depreciation_e28a7c83-13d4-434b-8a09-5aa5a93df46f" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_534b496e-f9bf-475e-8c33-133a24af2950" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/> |
| | <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_534b496e-f9bf-475e-8c33-133a24af2950" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_6b2f9ce9-02f2-4910-91a1-7feb0f4ad24c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/> |
| | <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_6b2f9ce9-02f2-4910-91a1-7feb0f4ad24c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_9db93ba5-24b2-43d0-83e2-be6939e2ff6e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/> |
| | <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_9db93ba5-24b2-43d0-83e2-be6939e2ff6e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_eb822085-4e09-4789-a8ab-b9644c78b44a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/> |
| | <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_eb822085-4e09-4789-a8ab-b9644c78b44a" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_a8ed7505-2ba1-41e5-b827-f1c7d0bf60a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/> |
| | <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edce1251-7a30-4d32-b2b6-7687e9ff98e8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_a8ed7505-2ba1-41e5-b827-f1c7d0bf60a3" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3447d2fc-cee1-479d-950a-a33e3eda8b1b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_73a84072-9f7d-475d-938a-285918907da0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3447d2fc-cee1-479d-950a-a33e3eda8b1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_73a84072-9f7d-475d-938a-285918907da0" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_08e68761-4c49-41ad-b258-48eb76d44613" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3447d2fc-cee1-479d-950a-a33e3eda8b1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_08e68761-4c49-41ad-b258-48eb76d44613" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c820cab9-a78c-4a54-a9cd-48923855a150" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3447d2fc-cee1-479d-950a-a33e3eda8b1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c820cab9-a78c-4a54-a9cd-48923855a150" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://mimedx.com/role/NatureofBusiness" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NatureofBusiness"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/NatureofBusiness" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/NatureofBusinessDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NatureofBusinessDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/NatureofBusinessDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPolicies" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPolicies"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/SignificantAccountingPolicies" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesPolicies"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesPolicies" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesSignificantAccountingPoliciesTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesSignificantAccountingPoliciesTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesNarrativeDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/Inventory" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Inventory"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/Inventory" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/InventoryTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#InventoryTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/InventoryTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/InventoryDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#InventoryDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/InventoryDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b632762d-28a4-4fd3-b1f7-1bf27173abfc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_36f31e73-eb42-4196-be48-61b64ba0d058" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterials"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b632762d-28a4-4fd3-b1f7-1bf27173abfc" xlink:to="loc_us-gaap_InventoryRawMaterials_36f31e73-eb42-4196-be48-61b64ba0d058" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_8b1876c4-8ec2-4fff-b464-314c6eff1140" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryWorkInProcess"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b632762d-28a4-4fd3-b1f7-1bf27173abfc" xlink:to="loc_us-gaap_InventoryWorkInProcess_8b1876c4-8ec2-4fff-b464-314c6eff1140" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_fd24cc53-49b1-4416-b7b4-2689226e1a34" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoods"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b632762d-28a4-4fd3-b1f7-1bf27173abfc" xlink:to="loc_us-gaap_InventoryFinishedGoods_fd24cc53-49b1-4416-b7b4-2689226e1a34" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipment" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipment"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/PropertyandEquipment" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/PropertyandEquipmentTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentSummaryofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentSummaryofPropertyandEquipmentDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/PropertyandEquipmentSummaryofPropertyandEquipmentDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ae44924d-19a2-4754-9375-6f4f12b507d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_f5eacd1e-0385-489d-bc08-938c57c13d9f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/> |
| | <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ae44924d-19a2-4754-9375-6f4f12b507d9" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_f5eacd1e-0385-489d-bc08-938c57c13d9f" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_99012067-75bc-4d2b-a5e4-485616c4541d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ae44924d-19a2-4754-9375-6f4f12b507d9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_99012067-75bc-4d2b-a5e4-485616c4541d" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentDepreciationExpenseDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentDepreciationExpenseDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/PropertyandEquipmentDepreciationExpenseDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/Leases" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Leases"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/Leases" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/LeasesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/LeasesTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesNarrativeDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/LeasesNarrativeDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/LeasesLeaseCostsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesLeaseCostsDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/LeasesLeaseCostsDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesSupplementalBalanceSheetInformationDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="extended"> |
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| <link:calculationLink xlink:role="http://mimedx.com/role/IntangibleAssets" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/IntangibleAssetsTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsActivitySummaryDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsActivitySummaryDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/IntangibleAssetsActivitySummaryDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_ef83466c-4ef7-462e-beb8-d065525efcfe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_abedf334-c07d-4b76-80e8-8f07490f11c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_ef83466c-4ef7-462e-beb8-d065525efcfe" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_abedf334-c07d-4b76-80e8-8f07490f11c7" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_dd164c12-8153-43bf-8c93-a1b81234df4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_ef83466c-4ef7-462e-beb8-d065525efcfe" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_dd164c12-8153-43bf-8c93-a1b81234df4d" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ad8efbc5-4516-4b12-8757-a4a42981d90e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b4a88db-22e4-4594-a2cb-695b8d5d441e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ad8efbc5-4516-4b12-8757-a4a42981d90e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b4a88db-22e4-4594-a2cb-695b8d5d441e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2f0c5a63-f7ca-4e3d-85bf-33113ece3198" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/> |
| | <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ad8efbc5-4516-4b12-8757-a4a42981d90e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_2f0c5a63-f7ca-4e3d-85bf-33113ece3198" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_f5e0ff99-c3b1-41ff-bacf-d1ccaad95bec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6dfafe89-b29e-484a-a7fd-fdcedf12ee7e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_f5e0ff99-c3b1-41ff-bacf-d1ccaad95bec" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6dfafe89-b29e-484a-a7fd-fdcedf12ee7e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_69274a1d-370f-4f53-adb5-f230550bfc55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_f5e0ff99-c3b1-41ff-bacf-d1ccaad95bec" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_69274a1d-370f-4f53-adb5-f230550bfc55" xlink:type="arc"/> |
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| <link:calculationLink xlink:role="http://mimedx.com/role/IntangibleAssetsAmortizationExpenseDetails" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_92f97b87-d1ec-44b9-8a2a-c7743ce23b62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_92f97b87-d1ec-44b9-8a2a-c7743ce23b62" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_8939fe6d-86c9-4941-817e-e5ee99bf092e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_8939fe6d-86c9-4941-817e-e5ee99bf092e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_f340d71e-1607-418e-b51c-e17fb265145b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_f340d71e-1607-418e-b51c-e17fb265145b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_13638a85-6437-4cc2-ace4-bdd6a93310d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_13638a85-6437-4cc2-ace4-bdd6a93310d9" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_mdxg_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_e2a0823a-d8ce-4610-91b0-745a6dcc603b" xlink:href="mdxg-20210331.xsd#mdxg_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_mdxg_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_e2a0823a-d8ce-4610-91b0-745a6dcc603b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3ace1524-97f8-4f40-b967-4e2e2568f457" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/> |
| | <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a725e33-abd8-4434-8c6b-282c7948a684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_3ace1524-97f8-4f40-b967-4e2e2568f457" xlink:type="arc"/> |
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| <link:roleRef roleURI="http://mimedx.com/role/AccruedExpenses" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpenses"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/AccruedExpenses" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/AccruedExpensesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpensesTables"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/AccruedExpensesTables" xlink:type="extended"/> |
| <link:roleRef roleURI="http://mimedx.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpensesDetails"/> |
| <link:calculationLink xlink:role="http://mimedx.com/role/AccruedExpensesDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrentAndNoncurrent_86d18938-6971-409d-98aa-9af4f62b2f76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrentAndNoncurrent"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrentAndNoncurrent_86d18938-6971-409d-98aa-9af4f62b2f76" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_mdxg_AccruedSettlementCostsCurrent_c6b67f6d-f783-467a-bab5-10f37ff0aa99" xlink:href="mdxg-20210331.xsd#mdxg_AccruedSettlementCostsCurrent"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_mdxg_AccruedSettlementCostsCurrent_c6b67f6d-f783-467a-bab5-10f37ff0aa99" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_fe1e85c1-2f5d-4513-a7ef-22d5100a848c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerRefundLiabilityCurrent"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_fe1e85c1-2f5d-4513-a7ef-22d5100a848c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_mdxg_AccruedClinicalTrialsCurrent_5468f841-f962-4772-b332-a2551a19bd91" xlink:href="mdxg-20210331.xsd#mdxg_AccruedClinicalTrialsCurrent"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_mdxg_AccruedClinicalTrialsCurrent_5468f841-f962-4772-b332-a2551a19bd91" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrent_b2ccac2e-02b1-4ecb-a384-11e239ec9ccb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedSalesCommissionCurrent"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrent_b2ccac2e-02b1-4ecb-a384-11e239ec9ccb" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_mdxg_AccruedRebates_a14c6f8e-3978-4922-bb4c-2049320e4b80" xlink:href="mdxg-20210331.xsd#mdxg_AccruedRebates"/> |
| | <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_mdxg_AccruedRebates_a14c6f8e-3978-4922-bb4c-2049320e4b80" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4312d3cf-e736-42e3-a0d8-b26327ac6a7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/> |
| | <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3a811f5-2d83-4919-8be8-3af42e06fbef" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4312d3cf-e736-42e3-a0d8-b26327ac6a7a" xlink:type="arc"/> |
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| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_3cfebcaf-38e3-479d-8a1b-96acb0356ca0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_fcbfdf98-8cf4-4a0d-bf75-edde89cf8efa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/> |
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| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_e2cf133d-f613-45fb-8efd-8eb3859f35b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/> |
| | <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_3cfebcaf-38e3-479d-8a1b-96acb0356ca0" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_e2cf133d-f613-45fb-8efd-8eb3859f35b7" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_ec6ddf8f-1285-4b2c-8812-8a00f6ae74c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/> |
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