SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Mimedx Group, Inc. – ‘10-Q’ for 3/31/21 – ‘EX-101.DEF’

On:  Wednesday, 4/28/21, at 4:14pm ET   ·   For:  3/31/21   ·   Accession #:  1376339-21-32   ·   File #:  1-35887

Previous ‘10-Q’:  ‘10-Q’ on 11/4/20 for 9/30/20   ·   Next:  ‘10-Q’ on 8/3/21 for 6/30/21   ·   Latest:  ‘10-Q’ on 4/30/24 for 3/31/24   ·   4 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 4/28/21  Mimedx Group, Inc.                10-Q        3/31/21   80:6.8M

Quarterly Report   —   Form 10-Q
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    670K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     25K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     25K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     22K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     22K 
12: R1          Cover                                               HTML     74K 
13: R2          Condensed Consolidated Balance Sheets               HTML    110K 
14: R3          Condensed Consolidated Balance Sheets               HTML     54K 
                (Parenthetical)                                                  
15: R4          Condensed Consolidated Statements of Operations     HTML     92K 
16: R5          Condensed Consolidated Statements of Stockholders'  HTML     71K 
                Deficit                                                          
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    100K 
18: R7          Nature of Business                                  HTML     30K 
19: R8          Significant Accounting Policies                     HTML     60K 
20: R9          Inventory                                           HTML     29K 
21: R10         Property and Equipment                              HTML     37K 
22: R11         Leases                                              HTML    108K 
23: R12         Intangible Assets                                   HTML     58K 
24: R13         Accrued Expenses                                    HTML     33K 
25: R14         Long Term Debt                                      HTML     76K 
26: R15         Net Loss Per Common Share                           HTML     59K 
27: R16         Equity                                              HTML     36K 
28: R17         Income taxes                                        HTML     26K 
29: R18         Supplemental Disclosure of Cash Flow and Non-Cash   HTML     33K 
                Investing and Financing Activities                               
30: R19         Contractual Commitments and Contingencies           HTML     44K 
31: R20         Revenue Data by Customer Type                       HTML     34K 
32: R21         Share-based Compensation                            HTML     55K 
33: R22         Subsequent Events                                   HTML     23K 
34: R23         Significant Accounting Policies (Policies)          HTML     89K 
35: R24         Significant Accounting Policies Significant         HTML     29K 
                Accounting Policies (Tables)                                     
36: R25         Inventory (Tables)                                  HTML     30K 
37: R26         Property and Equipment (Tables)                     HTML     38K 
38: R27         Leases (Tables)                                     HTML     86K 
39: R28         Intangible Assets (Tables)                          HTML     90K 
40: R29         Accrued Expenses (Tables)                           HTML     32K 
41: R30         Long Term Debt (Tables)                             HTML     61K 
42: R31         Net Loss Per Common Share (Tables)                  HTML     59K 
43: R32         Equity Equity (Tables)                              HTML     29K 
44: R33         Supplemental Disclosure of Cash Flow and Non-Cash   HTML     32K 
                Investing and Financing Activities (Tables)                      
45: R34         Revenue Data by Customer Type (Tables)              HTML     29K 
46: R35         Share-based Compensation (Tables)                   HTML     56K 
47: R36         Nature of Business (Details)                        HTML     33K 
48: R37         Significant Accounting Policies - Narrative         HTML     41K 
                (Details)                                                        
49: R38         Significant Accounting Policies - Assessment of     HTML     36K 
                Revenue under ASC 606 (Details)                                  
50: R39         Inventory (Details)                                 HTML     29K 
51: R40         Property and Equipment - Summary of Property and    HTML     40K 
                Equipment (Details)                                              
52: R41         Property and Equipment - Depreciation Expense       HTML     23K 
                (Details)                                                        
53: R42         Leases - Narrative (Details)                        HTML     24K 
54: R43         Leases - Lease Costs (Details)                      HTML     30K 
55: R44         Leases - Supplemental Balance Sheet Information     HTML     48K 
                (Details)                                                        
56: R45         Leases - Maturity of Lease Liabilities (Details)    HTML     85K 
57: R46         Intangible Assets - Activity Summary (Details)      HTML     52K 
58: R47         Intangible Assets - Amortization Expense (Details)  HTML     23K 
59: R48         Intangible Assets - Estimated Future Amortization   HTML     36K 
                Expense for Intangible Assets (Details)                          
60: R49         Accrued Expenses (Details)                          HTML     38K 
61: R50         Long Term Debt - Term Loan (Details)                HTML    107K 
62: R51         Long Term Debt - Term Loan Debt Issuance Costs      HTML     36K 
                (Details)                                                        
63: R52         Long Term Debt - Term Loan Balances (Details)       HTML     35K 
64: R53         Long Term Debt - Term Loan Interest Expense         HTML     41K 
                (Details)                                                        
65: R54         Long Term Debt - Term Loan Maturity (Details)       HTML     38K 
66: R55         Net Loss Per Common Share - Basic Net Loss Per      HTML     50K 
                Common Share (Details)                                           
67: R56         Net Loss Per Common Share - Diluted Net Loss Per    HTML     57K 
                Common Share (Details)                                           
68: R57         Equity - Narrative (Details)                        HTML     63K 
69: R58         Equity - Changes in Series B Preferred Stock        HTML     33K 
                (Details)                                                        
70: R59         Income taxes (Details)                              HTML     34K 
71: R60         Supplemental Disclosure of Cash Flow and Non-Cash   HTML     37K 
                Investing and Financing Activities (Details)                     
72: R61         Contractual Commitments and Contingencies -         HTML     37K 
                Narrative (Details)                                              
73: R62         Revenue Data by Customer Type (Details)             HTML     32K 
74: R63         Share-based Compensation - Narrative (Details)      HTML     25K 
75: R64         Share-based Compensation - Restricted Stock Awards  HTML     59K 
                (Details)                                                        
76: R65         Share-based Compensation - Stock Incentive Plans    HTML     64K 
                (Details)                                                        
78: XML         IDEA XML File -- Filing Summary                      XML    140K 
11: XML         XBRL Instance -- mdxg-20210331_htm                   XML   1.57M 
77: EXCEL       IDEA Workbook of Financial Reports                  XLSX     95K 
 7: EX-101.CAL  XBRL Calculations -- mdxg-20210331_cal               XML    284K 
 8: EX-101.DEF  XBRL Definitions -- mdxg-20210331_def                XML    391K 
 9: EX-101.LAB  XBRL Labels -- mdxg-20210331_lab                     XML   1.49M 
10: EX-101.PRE  XBRL Presentations -- mdxg-20210331_pre              XML    843K 
 6: EX-101.SCH  XBRL Schema -- mdxg-20210331                         XSD    152K 
79: JSON        XBRL Instance as JSON Data -- MetaLinks              350±   502K 
80: ZIP         XBRL Zipped Folder -- 0001376339-21-000032-xbrl      Zip    251K 


‘EX-101.DEF’   —   XBRL Definitions — mdxg-20210331_def


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- Copyright 2021 Workiva -->
<!-- r:47735b58-9df8-4e39-a256-e573fe186317,g:a51fa5fb-3e1e-46e1-b79d-79a89f93e5e7 -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
<link:roleRef roleURI="http://mimedx.com/role/Cover" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Cover"/>
<link:definitionLink xlink:role="http://mimedx.com/role/Cover" xlink:type="extended" id="i19d95b0060214b2684a5509ae8f1e117_Cover"/>
<link:roleRef roleURI="http://mimedx.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="mdxg-20210331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
<link:definitionLink xlink:role="http://mimedx.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended" id="if900763d6a37450e9b825d03823160bf_CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
<link:roleRef roleURI="http://mimedx.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="mdxg-20210331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
<link:definitionLink xlink:role="http://mimedx.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended" id="i638fae8b70a4441fbb15c421a823eba1_CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
<link:roleRef roleURI="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="mdxg-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
<link:definitionLink xlink:role="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended" id="i795e503f903f496e85c7012e853c69bf_CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
<link:roleRef roleURI="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSDEFICIT" xlink:type="simple" xlink:href="mdxg-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSDEFICIT"/>
<link:definitionLink xlink:role="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSDEFICIT" xlink:type="extended" id="i4247f6b79b39439fb7b1ad895d3d797e_CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSDEFICIT">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_b150ef24-0e31-4c53-b72d-a6861d5e31e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b150ef24-0e31-4c53-b72d-a6861d5e31e6" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_23288198-b7bc-43e3-beb6-55c4dc716edd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_SharesOutstanding_23288198-b7bc-43e3-beb6-55c4dc716edd" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d347cfb7-f9b1-49a7-bcfe-d6b0bb69d27d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockholdersEquity_d347cfb7-f9b1-49a7-bcfe-d6b0bb69d27d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_fc733b6f-7a56-4ff0-8733-b500484903a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_fc733b6f-7a56-4ff0-8733-b500484903a5" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_0c71d0b8-962a-42fc-9af0-3b3e54ebc898" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_0c71d0b8-962a-42fc-9af0-3b3e54ebc898" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_d47fec22-c132-4f00-af07-1aaa479e8be2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_d47fec22-c132-4f00-af07-1aaa479e8be2" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_86753803-052f-4885-9b36-a782cb886452" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_86753803-052f-4885-9b36-a782cb886452" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_b08c22a3-943d-430d-ad22-7c143e38345f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_b08c22a3-943d-430d-ad22-7c143e38345f" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_51e1ed16-310c-45a9-8f54-725a4a765adc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_51e1ed16-310c-45a9-8f54-725a4a765adc" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_2f993be9-70a5-4b52-ad90-737716f69b19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_2f993be9-70a5-4b52-ad90-737716f69b19" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_c998994a-2d26-42be-b694-c1af5e9a130f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_c998994a-2d26-42be-b694-c1af5e9a130f" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_7d78a4e7-a002-49a7-be0a-31dd73bd2248" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_7d78a4e7-a002-49a7-be0a-31dd73bd2248" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_257bdd79-d48f-4c01-a7a4-1d71bd8b22b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_257bdd79-d48f-4c01-a7a4-1d71bd8b22b0" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ca2419ca-d276-4b93-9f93-e2017cc9bc6e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_dc37715a-bd85-44ac-918c-9f018766cdc3" xlink:to="loc_us-gaap_NetIncomeLoss_ca2419ca-d276-4b93-9f93-e2017cc9bc6e" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_20229668-7f45-467a-853c-70647e0fb183" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesOutstanding"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_494c1bb6-3b20-4d92-b5d9-8d66cda73c1d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_4a102e8f-2252-458b-9f77-a5e20f790cc6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_b150ef24-0e31-4c53-b72d-a6861d5e31e6" xlink:to="loc_us-gaap_StatementTable_4a102e8f-2252-458b-9f77-a5e20f790cc6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4a102e8f-2252-458b-9f77-a5e20f790cc6" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0" xlink:to="loc_us-gaap_EquityComponentDomain_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a0c7e3a0-35f2-4c10-ae78-9c6daee182d0" xlink:to="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_c8bb9daa-03b5-4a81-80d5-9b335e0465d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:to="loc_us-gaap_CommonStockMember_c8bb9daa-03b5-4a81-80d5-9b335e0465d5" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_9c9c0008-bab0-4487-8953-7a9975ccb082" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_9c9c0008-bab0-4487-8953-7a9975ccb082" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_2f694783-fc41-4384-b0f4-a454cc101970" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:to="loc_us-gaap_TreasuryStockMember_2f694783-fc41-4384-b0f4-a454cc101970" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_7cc6bcbb-6cec-4545-a415-1e19543ef760" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0736f827-bcb3-4e9d-86e3-191eb0cd20ab" xlink:to="loc_us-gaap_RetainedEarningsMember_7cc6bcbb-6cec-4545-a415-1e19543ef760" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="mdxg-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
<link:definitionLink xlink:role="http://mimedx.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended" id="i0ac297e96bea4fbfbc193d7db5c60919_CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
<link:roleRef roleURI="http://mimedx.com/role/NatureofBusiness" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NatureofBusiness"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NatureofBusiness" xlink:type="extended" id="if095bfabbef64d9982a7fe2a1cb33761_NatureofBusiness"/>
<link:roleRef roleURI="http://mimedx.com/role/NatureofBusinessDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NatureofBusinessDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NatureofBusinessDetails" xlink:type="extended" id="i378aca80adae4b07a8c03bd3991e2621_NatureofBusinessDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemLineItems_aaed2bdb-b86b-45c8-b0ec-0130e6ee81e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_5a63ea53-00ed-4d9b-bb4e-4b2d3492552f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_aaed2bdb-b86b-45c8-b0ec-0130e6ee81e1" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_5a63ea53-00ed-4d9b-bb4e-4b2d3492552f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIncomeTaxRefunds_783a68bd-1c68-4dbc-83ad-a341db81f655" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIncomeTaxRefunds"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_aaed2bdb-b86b-45c8-b0ec-0130e6ee81e1" xlink:to="loc_us-gaap_ProceedsFromIncomeTaxRefunds_783a68bd-1c68-4dbc-83ad-a341db81f655" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_919f22bc-46be-4f1f-86d5-c8fbd47347dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxesReceivable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_aaed2bdb-b86b-45c8-b0ec-0130e6ee81e1" xlink:to="loc_us-gaap_IncomeTaxesReceivable_919f22bc-46be-4f1f-86d5-c8fbd47347dc" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemTable_62e370ab-e121-4b80-95db-01f53797b362" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_aaed2bdb-b86b-45c8-b0ec-0130e6ee81e1" xlink:to="loc_us-gaap_UnusualOrInfrequentItemTable_62e370ab-e121-4b80-95db-01f53797b362" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_62e370ab-e121-4b80-95db-01f53797b362" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_d3bebe4a-8d18-4fc2-ac4a-4a340a2d5e60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_cf7a94eb-6c64-4c1e-9f27-fe3d54486f3d" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_d3bebe4a-8d18-4fc2-ac4a-4a340a2d5e60" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_CARESActMember_b8ccc195-dac8-42e7-a5ad-f565e0e7546f" xlink:href="mdxg-20210331.xsd#mdxg_CARESActMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_d3bebe4a-8d18-4fc2-ac4a-4a340a2d5e60" xlink:to="loc_mdxg_CARESActMember_b8ccc195-dac8-42e7-a5ad-f565e0e7546f" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPolicies" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPolicies"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SignificantAccountingPolicies" xlink:type="extended" id="ia056e10fa33c485bb5fadae69e955bf2_SignificantAccountingPolicies"/>
<link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesPolicies"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesPolicies" xlink:type="extended" id="i9b806353a68148d99d0a7b858e1c56f8_SignificantAccountingPoliciesPolicies"/>
<link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesSignificantAccountingPoliciesTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesSignificantAccountingPoliciesTables" xlink:type="extended" id="i7199f488b8b249a39099e8cd2da89456_SignificantAccountingPoliciesSignificantAccountingPoliciesTables"/>
<link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesNarrativeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="extended" id="i3d559da320cd4634819157c0003ad0ec_SignificantAccountingPoliciesNarrativeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_7a0be797-73dd-4aca-a4e0-c78f5ebe4083" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_7a0be797-73dd-4aca-a4e0-c78f5ebe4083" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportingUnits_ce569b96-37a4-4bfe-a671-fc33301cc2d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NumberOfReportingUnits"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_NumberOfReportingUnits_ce569b96-37a4-4bfe-a671-fc33301cc2d5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_a25cf963-8ba0-4e01-9f4f-502ed56da475" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_a25cf963-8ba0-4e01-9f4f-502ed56da475" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TypicalPaymentPeriodforCustomers_52bf4c7d-fe2e-488a-b75f-68b80e91cc57" xlink:href="mdxg-20210331.xsd#mdxg_TypicalPaymentPeriodforCustomers"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_mdxg_TypicalPaymentPeriodforCustomers_52bf4c7d-fe2e-488a-b75f-68b80e91cc57" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_GroupPurchasingOrganizationAdministrativeFeesasPercentofPurchaseVolume_fa65e02a-ff01-424f-9510-44d70e6fa944" xlink:href="mdxg-20210331.xsd#mdxg_GroupPurchasingOrganizationAdministrativeFeesasPercentofPurchaseVolume"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_mdxg_GroupPurchasingOrganizationAdministrativeFeesasPercentofPurchaseVolume_fa65e02a-ff01-424f-9510-44d70e6fa944" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_fc15d84d-d776-43f3-908b-d34689a2a265" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_fc15d84d-d776-43f3-908b-d34689a2a265" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsCostIncurredToRenewOrExtend_422e3abc-45aa-4dcb-8fbe-868198a0c8db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsCostIncurredToRenewOrExtend"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsCostIncurredToRenewOrExtend_422e3abc-45aa-4dcb-8fbe-868198a0c8db" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8677455c-b084-42b9-ae3d-8ae7be038925" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4f635151-33e0-433d-b68a-fde481c1fcf6" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8677455c-b084-42b9-ae3d-8ae7be038925" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8677455c-b084-42b9-ae3d-8ae7be038925" xlink:to="loc_srt_RangeAxis_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e" xlink:to="loc_srt_RangeMember_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_92ed1e2d-c6fc-4bc9-b966-3f3bdab8c695" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_3364d2ec-1ba1-444c-9c37-1d82ec79ab2e" xlink:to="loc_srt_RangeMember_92ed1e2d-c6fc-4bc9-b966-3f3bdab8c695" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_1b1b605e-ba01-40c5-a1e2-9adbff9d9077" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_92ed1e2d-c6fc-4bc9-b966-3f3bdab8c695" xlink:to="loc_srt_MinimumMember_1b1b605e-ba01-40c5-a1e2-9adbff9d9077" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_2b128f42-0cc7-4688-b7f8-694ce08a5e75" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_92ed1e2d-c6fc-4bc9-b966-3f3bdab8c695" xlink:to="loc_srt_MaximumMember_2b128f42-0cc7-4688-b7f8-694ce08a5e75" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details" xlink:type="extended" id="i190d0a09e2514b1295dbf1f32eece56d_SignificantAccountingPoliciesAssessmentofRevenueunderASC606Details">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems_ca54bb06-270f-4be2-8bb9-54fd29afec41" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5305f899-cd51-4425-a6be-046f75380c61" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems_ca54bb06-270f-4be2-8bb9-54fd29afec41" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5305f899-cd51-4425-a6be-046f75380c61" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_066cb495-56d4-47c9-a894-ac94da80ece2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems_ca54bb06-270f-4be2-8bb9-54fd29afec41" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_066cb495-56d4-47c9-a894-ac94da80ece2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_79fde96c-baef-46ab-8d45-c22d92a83ba4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems_ca54bb06-270f-4be2-8bb9-54fd29afec41" xlink:to="loc_us-gaap_GrossProfit_79fde96c-baef-46ab-8d45-c22d92a83ba4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionTable_822ea285-16ef-41d4-af46-254c33ccd1ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionLineItems_ca54bb06-270f-4be2-8bb9-54fd29afec41" xlink:to="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionTable_822ea285-16ef-41d4-af46-254c33ccd1ef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_8ed9f19f-a08e-45c3-b828-52bda0c67021" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueInitialApplicationPeriodCumulativeEffectTransitionTable_822ea285-16ef-41d4-af46-254c33ccd1ef" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_8ed9f19f-a08e-45c3-b828-52bda0c67021" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_8ed9f19f-a08e-45c3-b828-52bda0c67021_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_8ed9f19f-a08e-45c3-b828-52bda0c67021" xlink:to="loc_us-gaap_TypeOfAdoptionMember_8ed9f19f-a08e-45c3-b828-52bda0c67021_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_a9cc964d-2cc6-401c-9de6-b09426ee45f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_8ed9f19f-a08e-45c3-b828-52bda0c67021" xlink:to="loc_us-gaap_TypeOfAdoptionMember_a9cc964d-2cc6-401c-9de6-b09426ee45f6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_3cefee97-5455-403e-a4ec-6f9bc86e35bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_a9cc964d-2cc6-401c-9de6-b09426ee45f6" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_3cefee97-5455-403e-a4ec-6f9bc86e35bc" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/Inventory" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Inventory"/>
<link:definitionLink xlink:role="http://mimedx.com/role/Inventory" xlink:type="extended" id="icd73987adce94afc8ac5958b6349d82a_Inventory"/>
<link:roleRef roleURI="http://mimedx.com/role/InventoryTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#InventoryTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/InventoryTables" xlink:type="extended" id="i24b6f03fcde7459e9a1a8261866a178d_InventoryTables"/>
<link:roleRef roleURI="http://mimedx.com/role/InventoryDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#InventoryDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/InventoryDetails" xlink:type="extended" id="i47529665f8b84cfc91e179f6ad6279eb_InventoryDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipment" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipment"/>
<link:definitionLink xlink:role="http://mimedx.com/role/PropertyandEquipment" xlink:type="extended" id="icd208ae7060d4d47aa4e8b32bc1b5a6c_PropertyandEquipment"/>
<link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/PropertyandEquipmentTables" xlink:type="extended" id="i1125d971f5034ef98e60a6523038c00b_PropertyandEquipmentTables"/>
<link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentSummaryofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentSummaryofPropertyandEquipmentDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/PropertyandEquipmentSummaryofPropertyandEquipmentDetails" xlink:type="extended" id="icebe162d1aa24f5583464f07ac17cc09_PropertyandEquipmentSummaryofPropertyandEquipmentDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_bf40a4e1-9124-456b-8325-cf06c0e20d72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_44237ad9-654f-4f26-af60-66c33abed2ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_bf40a4e1-9124-456b-8325-cf06c0e20d72" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_44237ad9-654f-4f26-af60-66c33abed2ee" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_9cb69e6d-d2d5-46c2-91f0-2960d427e306" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_bf40a4e1-9124-456b-8325-cf06c0e20d72" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_9cb69e6d-d2d5-46c2-91f0-2960d427e306" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_253f92ee-4018-40be-b5bb-e30ec83e2fd9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_bf40a4e1-9124-456b-8325-cf06c0e20d72" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_253f92ee-4018-40be-b5bb-e30ec83e2fd9" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a2f78a88-6efc-4b7a-bfa0-36228319309f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_bf40a4e1-9124-456b-8325-cf06c0e20d72" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a2f78a88-6efc-4b7a-bfa0-36228319309f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_dfdf2827-715f-4495-b98d-f0e31580d28c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a2f78a88-6efc-4b7a-bfa0-36228319309f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_dfdf2827-715f-4495-b98d-f0e31580d28c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dfdf2827-715f-4495-b98d-f0e31580d28c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_dfdf2827-715f-4495-b98d-f0e31580d28c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dfdf2827-715f-4495-b98d-f0e31580d28c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_dfdf2827-715f-4495-b98d-f0e31580d28c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_248d4b7b-02fd-4c48-bc47-240df1e96694" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_248d4b7b-02fd-4c48-bc47-240df1e96694" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentMember_77764927-1c84-4d4d-99e9-d6de360db488" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquipmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:to="loc_us-gaap_EquipmentMember_77764927-1c84-4d4d-99e9-d6de360db488" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_68b621ec-d830-45f3-abd5-f1e895bdd4c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FurnitureAndFixturesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_68b621ec-d830-45f3-abd5-f1e895bdd4c4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_75b41fdf-cd7e-45c1-9fcc-29e2e618241f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConstructionInProgressMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:to="loc_us-gaap_ConstructionInProgressMember_75b41fdf-cd7e-45c1-9fcc-29e2e618241f" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_AssetRetirementCostMember_79ad24bd-b3d8-41c3-9a75-78525dcbd03b" xlink:href="mdxg-20210331.xsd#mdxg_AssetRetirementCostMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ab216ad3-3d22-48cc-9735-fb8bb8ddce11" xlink:to="loc_mdxg_AssetRetirementCostMember_79ad24bd-b3d8-41c3-9a75-78525dcbd03b" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/PropertyandEquipmentDepreciationExpenseDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#PropertyandEquipmentDepreciationExpenseDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/PropertyandEquipmentDepreciationExpenseDetails" xlink:type="extended" id="i962b4c5aa05c47deba820e317f530114_PropertyandEquipmentDepreciationExpenseDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/Leases" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Leases"/>
<link:definitionLink xlink:role="http://mimedx.com/role/Leases" xlink:type="extended" id="i8dd2ad7d1cf248eda6d48618ebaeb7e4_Leases"/>
<link:roleRef roleURI="http://mimedx.com/role/LeasesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LeasesTables" xlink:type="extended" id="i232dc20db755459ea0bf0a2b463cdcd3_LeasesTables"/>
<link:roleRef roleURI="http://mimedx.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesNarrativeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LeasesNarrativeDetails" xlink:type="extended" id="i5a6c1771f01e43da9615b85fea443798_LeasesNarrativeDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/LeasesLeaseCostsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesLeaseCostsDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LeasesLeaseCostsDetails" xlink:type="extended" id="i76616eba9d81485894e5b00efd38fc1f_LeasesLeaseCostsDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesSupplementalBalanceSheetInformationDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="extended" id="i5235530e10874a6e80ecc83836bc5e61_LeasesSupplementalBalanceSheetInformationDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/LeasesMaturityofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LeasesMaturityofLeaseLiabilitiesDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LeasesMaturityofLeaseLiabilitiesDetails" xlink:type="extended" id="i2f5b2dce935a4c33bdfeaf764c53a106_LeasesMaturityofLeaseLiabilitiesDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/IntangibleAssets" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssets"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IntangibleAssets" xlink:type="extended" id="i2fe83148b49b4347b2f59b72dfbeccb3_IntangibleAssets"/>
<link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IntangibleAssetsTables" xlink:type="extended" id="i884fd66667c1403896b74b90e3b45646_IntangibleAssetsTables"/>
<link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsActivitySummaryDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsActivitySummaryDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IntangibleAssetsActivitySummaryDetails" xlink:type="extended" id="i60fd77cd28094d2b9f0b256bff35fd93_IntangibleAssetsActivitySummaryDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f6035d7d-89c2-4429-b4fc-2eff9f5585fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_559911c2-7d3a-4392-8ec7-a11d2521b768" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f6035d7d-89c2-4429-b4fc-2eff9f5585fa" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_559911c2-7d3a-4392-8ec7-a11d2521b768" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_9f28c6f6-6a79-4bf6-ac39-f867ce43c852" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f6035d7d-89c2-4429-b4fc-2eff9f5585fa" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_9f28c6f6-6a79-4bf6-ac39-f867ce43c852" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e07f120b-e198-4b59-b6a0-db3eddff26a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f6035d7d-89c2-4429-b4fc-2eff9f5585fa" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e07f120b-e198-4b59-b6a0-db3eddff26a2" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c9143cc4-1f85-4238-b29e-3be5e90114fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f6035d7d-89c2-4429-b4fc-2eff9f5585fa" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c9143cc4-1f85-4238-b29e-3be5e90114fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_b742614e-df54-43a3-984f-6267ec414e77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c9143cc4-1f85-4238-b29e-3be5e90114fe" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_b742614e-df54-43a3-984f-6267ec414e77" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b742614e-df54-43a3-984f-6267ec414e77_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_b742614e-df54-43a3-984f-6267ec414e77" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b742614e-df54-43a3-984f-6267ec414e77_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_b742614e-df54-43a3-984f-6267ec414e77" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_78c4500a-2b94-4a51-8ff5-f91d66ae8949" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PatentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:to="loc_us-gaap_PatentsMember_78c4500a-2b94-4a51-8ff5-f91d66ae8949" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_8e169d22-bf7d-4e01-b1b6-28a3bc17fac0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:to="loc_us-gaap_LicensingAgreementsMember_8e169d22-bf7d-4e01-b1b6-28a3bc17fac0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_CustomerAndSupplierRelationshipsMember_ce9c2c8a-f5c8-4e73-94d6-21cc6708f1e4" xlink:href="mdxg-20210331.xsd#mdxg_CustomerAndSupplierRelationshipsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:to="loc_mdxg_CustomerAndSupplierRelationshipsMember_ce9c2c8a-f5c8-4e73-94d6-21cc6708f1e4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncompeteAgreementsMember_7d1287b9-c33a-4718-8035-fbe2f2f81815" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoncompeteAgreementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_3a05919b-6f20-4747-8cb5-c8d2a02c7f30" xlink:to="loc_us-gaap_NoncompeteAgreementsMember_7d1287b9-c33a-4718-8035-fbe2f2f81815" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_51f68626-6599-47d1-ab38-1978215686d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c9143cc4-1f85-4238-b29e-3be5e90114fe" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_51f68626-6599-47d1-ab38-1978215686d9" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_51f68626-6599-47d1-ab38-1978215686d9_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_51f68626-6599-47d1-ab38-1978215686d9" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_51f68626-6599-47d1-ab38-1978215686d9_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7503883f-55e7-458a-b750-f70afa7dd8d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_51f68626-6599-47d1-ab38-1978215686d9" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7503883f-55e7-458a-b750-f70afa7dd8d7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksAndTradeNamesMember_f8da1e93-754d-4e4d-956c-c497f2be3c8f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TrademarksAndTradeNamesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7503883f-55e7-458a-b750-f70afa7dd8d7" xlink:to="loc_us-gaap_TrademarksAndTradeNamesMember_f8da1e93-754d-4e4d-956c-c497f2be3c8f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_PatentsinProcessMember_9382cc03-26aa-4152-8ea1-b785bc20c83f" xlink:href="mdxg-20210331.xsd#mdxg_PatentsinProcessMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7503883f-55e7-458a-b750-f70afa7dd8d7" xlink:to="loc_mdxg_PatentsinProcessMember_9382cc03-26aa-4152-8ea1-b785bc20c83f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_7876d345-68a4-4100-beca-afe79eb8a564" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_d9414a8f-5f0b-4a72-a228-9fc2ac878657" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_7876d345-68a4-4100-beca-afe79eb8a564" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_d9414a8f-5f0b-4a72-a228-9fc2ac878657" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_3473b955-a5bf-4235-998f-725e52cda597" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_7876d345-68a4-4100-beca-afe79eb8a564" xlink:to="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_3473b955-a5bf-4235-998f-725e52cda597" xlink:type="arc" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_06140848-fd1f-4615-9c50-ba5d944c32c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_3473b955-a5bf-4235-998f-725e52cda597" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_06140848-fd1f-4615-9c50-ba5d944c32c9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_06140848-fd1f-4615-9c50-ba5d944c32c9_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5cb658f7-516f-436e-8695-1edd587aa9c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksAndTradeNamesMember_51204dae-8681-4a15-a1ec-ea46582cefb6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TrademarksAndTradeNamesMember"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_PatentsinProcessMember_5ab478a1-6c83-44dc-8d53-45a71b423f1c" xlink:href="mdxg-20210331.xsd#mdxg_PatentsinProcessMember"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsAmortizationExpenseDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsAmortizationExpenseDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IntangibleAssetsAmortizationExpenseDetails" xlink:type="extended" id="i39683e836faf4be4a2ea1ec17d5b13ec_IntangibleAssetsAmortizationExpenseDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails" xlink:type="extended" id="i8483592988b5406b8e52a2569d85fe0c_IntangibleAssetsEstimatedFutureAmortizationExpenseforIntangibleAssetsDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/AccruedExpenses" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpenses"/>
<link:definitionLink xlink:role="http://mimedx.com/role/AccruedExpenses" xlink:type="extended" id="i7f08b8e73214409abd089cda93ffd3fb_AccruedExpenses"/>
<link:roleRef roleURI="http://mimedx.com/role/AccruedExpensesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpensesTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/AccruedExpensesTables" xlink:type="extended" id="idf5c5901cff74d4ab6a0ea45f3dce2b7_AccruedExpensesTables"/>
<link:roleRef roleURI="http://mimedx.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#AccruedExpensesDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/AccruedExpensesDetails" xlink:type="extended" id="i4262f1e473354ccfa0efe45ef43cf504_AccruedExpensesDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebt" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebt"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebt" xlink:type="extended" id="i28f482d222f0480a9ad5617623624dc3_LongTermDebt"/>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTables" xlink:type="extended" id="id54f3bd879154ffa9a48bb4fa2a24969_LongTermDebtTables"/>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTermLoanDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTermLoanDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTermLoanDetails" xlink:type="extended" id="i814158f545bd4141869cbc4c067eee8b_LongTermDebtTermLoanDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_90750dd7-d0f5-44a9-801a-2723f71d2513" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_90750dd7-d0f5-44a9-801a-2723f71d2513" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentInterestRateFloorPercentage_1433023f-bad4-476b-a046-9960cdff4f6a" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentInterestRateFloorPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtInstrumentInterestRateFloorPercentage_1433023f-bad4-476b-a046-9960cdff4f6a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_fbebb489-6206-4c2c-ae51-c0739101251e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_fbebb489-6206-4c2c-ae51-c0739101251e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TotalNetLeverageRatio_d07bbbb4-f0ad-4b98-b21f-dd6b421c537d" xlink:href="mdxg-20210331.xsd#mdxg_TotalNetLeverageRatio"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_TotalNetLeverageRatio_d07bbbb4-f0ad-4b98-b21f-dd6b421c537d" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentDefaultInterestRate_10494d85-6b8b-4ac2-a3c2-49058ff16b72" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentDefaultInterestRate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtInstrumentDefaultInterestRate_10494d85-6b8b-4ac2-a3c2-49058ff16b72" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_e7a90141-ad2c-4e9c-ab9e-abb7ce4d5505" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_e7a90141-ad2c-4e9c-ab9e-abb7ce4d5505" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtCovenantMinimumLiquidity_be842ba3-422a-46c7-b9cb-e8b2259bf6f1" xlink:href="mdxg-20210331.xsd#mdxg_DebtCovenantMinimumLiquidity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtCovenantMinimumLiquidity_be842ba3-422a-46c7-b9cb-e8b2259bf6f1" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPercent_4b2538ee-f718-49c6-941f-774e9986d026" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPercent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPercent_4b2538ee-f718-49c6-941f-774e9986d026" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPlusAccruedInterestPercent_40c8b640-347a-476d-aa10-c02e748ace67" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPlusAccruedInterestPercent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtInstrumentPrepaymentPenaltyasPercentofPrepaidPrincipalPlusAccruedInterestPercent_40c8b640-347a-476d-aa10-c02e748ace67" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentUnusedCapacityCommitmentFeePercentage_5f475775-e3e1-45aa-ba7a-f6b8b5018b86" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentUnusedCapacityCommitmentFeePercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_mdxg_DebtInstrumentUnusedCapacityCommitmentFeePercentage_5f475775-e3e1-45aa-ba7a-f6b8b5018b86" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_7330fd2e-099c-4942-a22d-c70c9619d680" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_LongTermDebtFairValue_7330fd2e-099c-4942-a22d-c70c9619d680" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentPeriodicPayment_4cc11ca2-6cb7-417f-b43e-3a9764672497" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentPeriodicPayment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentPeriodicPayment_4cc11ca2-6cb7-417f-b43e-3a9764672497" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_ffe9d2cb-8de0-4eef-8bc3-05025e9bae17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_ffe9d2cb-8de0-4eef-8bc3-05025e9bae17" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_23814395-88cc-4d58-963d-a8ea2c2699bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_23814395-88cc-4d58-963d-a8ea2c2699bf" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateIncreaseDecrease_8cbdf563-fcbe-421f-9805-24840f8eb4a0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateIncreaseDecrease"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentInterestRateIncreaseDecrease_8cbdf563-fcbe-421f-9805-24840f8eb4a0" xlink:type="arc" order="14"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b0eaeb02-4341-4eb4-8406-1fb1f0b07c62" xlink:to="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_0a6b00cc-e8e2-496b-b991-3339cf70cf88" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_srt_RangeAxis_0a6b00cc-e8e2-496b-b991-3339cf70cf88" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0a6b00cc-e8e2-496b-b991-3339cf70cf88_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_0a6b00cc-e8e2-496b-b991-3339cf70cf88" xlink:to="loc_srt_RangeMember_0a6b00cc-e8e2-496b-b991-3339cf70cf88_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ca8352ed-3a9d-4d92-81c9-5806edaddb09" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_0a6b00cc-e8e2-496b-b991-3339cf70cf88" xlink:to="loc_srt_RangeMember_ca8352ed-3a9d-4d92-81c9-5806edaddb09" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_182e1460-fb6f-41bd-b432-17aad3302cef" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ca8352ed-3a9d-4d92-81c9-5806edaddb09" xlink:to="loc_srt_MinimumMember_182e1460-fb6f-41bd-b432-17aad3302cef" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_9be59c90-ded6-44dc-b983-e60bf072ec0d" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ca8352ed-3a9d-4d92-81c9-5806edaddb09" xlink:to="loc_srt_MaximumMember_9be59c90-ded6-44dc-b983-e60bf072ec0d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_a8f28cde-4c25-47ee-9761-a546becec248" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_StatementScenarioAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_srt_StatementScenarioAxis_a8f28cde-4c25-47ee-9761-a546becec248" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_a8f28cde-4c25-47ee-9761-a546becec248_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_a8f28cde-4c25-47ee-9761-a546becec248" xlink:to="loc_srt_ScenarioUnspecifiedDomain_a8f28cde-4c25-47ee-9761-a546becec248_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_edfa2f0f-71f6-4ec1-87e5-2426c0db6489" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_a8f28cde-4c25-47ee-9761-a546becec248" xlink:to="loc_srt_ScenarioUnspecifiedDomain_edfa2f0f-71f6-4ec1-87e5-2426c0db6489" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_a883807f-2105-40cb-ae38-51279982b6b8" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioForecastMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_edfa2f0f-71f6-4ec1-87e5-2426c0db6489" xlink:to="loc_srt_ScenarioForecastMember_a883807f-2105-40cb-ae38-51279982b6b8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_13ccee7c-a845-4906-9c38-b01a5248eeaf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_13ccee7c-a845-4906-9c38-b01a5248eeaf" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_13ccee7c-a845-4906-9c38-b01a5248eeaf_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_13ccee7c-a845-4906-9c38-b01a5248eeaf" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_13ccee7c-a845-4906-9c38-b01a5248eeaf_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_8b43d96f-0e48-43a6-98b4-518a5a88704e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_13ccee7c-a845-4906-9c38-b01a5248eeaf" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_8b43d96f-0e48-43a6-98b4-518a5a88704e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_f4419f87-87cd-41ac-8742-84b704db7fc6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_8b43d96f-0e48-43a6-98b4-518a5a88704e" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_f4419f87-87cd-41ac-8742-84b704db7fc6" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_0647c1f7-a617-41b3-b6ad-d1443435aa28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_us-gaap_DebtInstrumentAxis_0647c1f7-a617-41b3-b6ad-d1443435aa28" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0647c1f7-a617-41b3-b6ad-d1443435aa28_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_0647c1f7-a617-41b3-b6ad-d1443435aa28" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0647c1f7-a617-41b3-b6ad-d1443435aa28_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_0647c1f7-a617-41b3-b6ad-d1443435aa28" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanMember_bd573c1c-8d6e-4ee2-9e7f-e0983bf2a084" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanMember_bd573c1c-8d6e-4ee2-9e7f-e0983bf2a084" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_FinancingTransactionsMember_33ef2f55-49a4-4a1e-9a6f-375c07a62e72" xlink:href="mdxg-20210331.xsd#mdxg_FinancingTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_FinancingTransactionsMember_33ef2f55-49a4-4a1e-9a6f-375c07a62e72" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan2.0xbutGreaterthanorEqualto1.0xMember_42aefd83-a119-4c61-9948-20b783331850" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan2.0xbutGreaterthanorEqualto1.0xMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan2.0xbutGreaterthanorEqualto1.0xMember_42aefd83-a119-4c61-9948-20b783331850" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan1.0xMember_96af6eb9-9d46-4c82-b33e-2a9c87401588" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan1.0xMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanTotalNetLeverageRatioLessthan1.0xMember_96af6eb9-9d46-4c82-b33e-2a9c87401588" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_CreditFacilitiesMember_6c3377e2-2aed-44d7-946d-7aa6a7018688" xlink:href="mdxg-20210331.xsd#mdxg_CreditFacilitiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_CreditFacilitiesMember_6c3377e2-2aed-44d7-946d-7aa6a7018688" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_59da2f65-1dee-462f-a042-9ddb05b3e6ef" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_59da2f65-1dee-462f-a042-9ddb05b3e6ef" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TermLoanAgreementMember_d3198f39-f609-4ea2-8437-299a52b47a6d" xlink:href="mdxg-20210331.xsd#mdxg_TermLoanAgreementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_TermLoanAgreementMember_d3198f39-f609-4ea2-8437-299a52b47a6d" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_AmendedTermLoanAgreementMember_3b99342a-5526-48e6-b9a2-c515a06405e1" xlink:href="mdxg-20210331.xsd#mdxg_AmendedTermLoanAgreementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7ea38dbf-06d9-4f94-a249-3f8b96b0bf4d" xlink:to="loc_mdxg_AmendedTermLoanAgreementMember_3b99342a-5526-48e6-b9a2-c515a06405e1" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_6472fd84-35fc-4cc5-9b3b-12db6435a15c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableRateAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_us-gaap_VariableRateAxis_6472fd84-35fc-4cc5-9b3b-12db6435a15c" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_6472fd84-35fc-4cc5-9b3b-12db6435a15c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableRateDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_6472fd84-35fc-4cc5-9b3b-12db6435a15c" xlink:to="loc_us-gaap_VariableRateDomain_6472fd84-35fc-4cc5-9b3b-12db6435a15c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_0492794b-095c-46d7-b73f-8a3e64873064" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableRateDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_6472fd84-35fc-4cc5-9b3b-12db6435a15c" xlink:to="loc_us-gaap_VariableRateDomain_0492794b-095c-46d7-b73f-8a3e64873064" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_24d92c5c-8500-494c-af1a-60a2d8155600" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_0492794b-095c-46d7-b73f-8a3e64873064" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_24d92c5c-8500-494c-af1a-60a2d8155600" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsEffectiveSwapRateMember_1747acf1-bd73-4416-97d2-825318950433" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsEffectiveSwapRateMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_0492794b-095c-46d7-b73f-8a3e64873064" xlink:to="loc_us-gaap_FederalFundsEffectiveSwapRateMember_1747acf1-bd73-4416-97d2-825318950433" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrimeRateMember_99836ec9-434b-470c-9122-d1b45072cf48" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrimeRateMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_0492794b-095c-46d7-b73f-8a3e64873064" xlink:to="loc_us-gaap_PrimeRateMember_99836ec9-434b-470c-9122-d1b45072cf48" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_27c0ffc8-1736-4464-8861-57ef8e8c77fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_09e7e8ab-aea0-48ea-b0a3-a28d4f4cc575" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_27c0ffc8-1736-4464-8861-57ef8e8c77fa" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_27c0ffc8-1736-4464-8861-57ef8e8c77fa_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_27c0ffc8-1736-4464-8861-57ef8e8c77fa" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_27c0ffc8-1736-4464-8861-57ef8e8c77fa_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_8e4793c3-3b23-47ca-89d8-97ab69cd5293" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_27c0ffc8-1736-4464-8861-57ef8e8c77fa" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_8e4793c3-3b23-47ca-89d8-97ab69cd5293" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_bb48639c-ece9-4392-9783-e6355bfe9b7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_8e4793c3-3b23-47ca-89d8-97ab69cd5293" xlink:to="loc_us-gaap_SubsequentEventMember_bb48639c-ece9-4392-9783-e6355bfe9b7d" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTermLoanDebtIssuanceCostsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTermLoanDebtIssuanceCostsDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTermLoanDebtIssuanceCostsDetails" xlink:type="extended" id="ia03d5f3d10244f67a0bc767cd683a65f_LongTermDebtTermLoanDebtIssuanceCostsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_809d683e-6aec-4cb8-ac1a-fa716d757263" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_71f11367-a82c-4663-b0a0-5dbfe15b9584" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_809d683e-6aec-4cb8-ac1a-fa716d757263" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_71f11367-a82c-4663-b0a0-5dbfe15b9584" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_7c770e1d-67d4-4269-bb1b-14691fd4c52a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_809d683e-6aec-4cb8-ac1a-fa716d757263" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_7c770e1d-67d4-4269-bb1b-14691fd4c52a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_fa8bec18-435a-47eb-8393-44ab37d6377f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_809d683e-6aec-4cb8-ac1a-fa716d757263" xlink:to="loc_us-gaap_DebtInstrumentTable_fa8bec18-435a-47eb-8393-44ab37d6377f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_d19555f5-be15-4291-88cf-7d2b1543f8c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fa8bec18-435a-47eb-8393-44ab37d6377f" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_d19555f5-be15-4291-88cf-7d2b1543f8c5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_d19555f5-be15-4291-88cf-7d2b1543f8c5_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_d19555f5-be15-4291-88cf-7d2b1543f8c5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_d19555f5-be15-4291-88cf-7d2b1543f8c5_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_d69ce801-81ac-4248-9811-8d3c73064467" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_d19555f5-be15-4291-88cf-7d2b1543f8c5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_d69ce801-81ac-4248-9811-8d3c73064467" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMember_ad3549f6-8544-4e52-80af-4ecf0672420f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_d69ce801-81ac-4248-9811-8d3c73064467" xlink:to="loc_us-gaap_LongTermDebtMember_ad3549f6-8544-4e52-80af-4ecf0672420f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_3a05011c-1c11-4806-a71b-eac6b379d1fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherCurrentAssetsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_d69ce801-81ac-4248-9811-8d3c73064467" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_3a05011c-1c11-4806-a71b-eac6b379d1fc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_3438689e-f273-4e9d-8ba6-b7688913055c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fa8bec18-435a-47eb-8393-44ab37d6377f" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_3438689e-f273-4e9d-8ba6-b7688913055c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3438689e-f273-4e9d-8ba6-b7688913055c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3438689e-f273-4e9d-8ba6-b7688913055c" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3438689e-f273-4e9d-8ba6-b7688913055c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_bff2c23d-acc3-4e69-bbfd-4055a09b6d7f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3438689e-f273-4e9d-8ba6-b7688913055c" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_bff2c23d-acc3-4e69-bbfd-4055a09b6d7f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_4b0c947f-babf-4dc9-9151-0c4fae40edda" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_bff2c23d-acc3-4e69-bbfd-4055a09b6d7f" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_4b0c947f-babf-4dc9-9151-0c4fae40edda" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_db43fc23-e59e-4f9b-8936-113147ccc78e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fa8bec18-435a-47eb-8393-44ab37d6377f" xlink:to="loc_us-gaap_DebtInstrumentAxis_db43fc23-e59e-4f9b-8936-113147ccc78e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_db43fc23-e59e-4f9b-8936-113147ccc78e_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_db43fc23-e59e-4f9b-8936-113147ccc78e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_db43fc23-e59e-4f9b-8936-113147ccc78e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_aaba923f-242c-49d0-9c70-0ea2ee9814b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_db43fc23-e59e-4f9b-8936-113147ccc78e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_aaba923f-242c-49d0-9c70-0ea2ee9814b3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_CreditFacilitiesMember_363e0700-6849-479c-b011-691163bc95f4" xlink:href="mdxg-20210331.xsd#mdxg_CreditFacilitiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_aaba923f-242c-49d0-9c70-0ea2ee9814b3" xlink:to="loc_mdxg_CreditFacilitiesMember_363e0700-6849-479c-b011-691163bc95f4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanMember_755e4ca7-5410-4af6-ae3d-432eef7bae9b" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_mdxg_CreditFacilitiesMember_363e0700-6849-479c-b011-691163bc95f4" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanMember_755e4ca7-5410-4af6-ae3d-432eef7bae9b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_c285fd89-4575-4236-ae70-39e427cf4c4c" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_mdxg_CreditFacilitiesMember_363e0700-6849-479c-b011-691163bc95f4" xlink:to="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_c285fd89-4575-4236-ae70-39e427cf4c4c" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTermLoanBalancesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTermLoanBalancesDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTermLoanBalancesDetails" xlink:type="extended" id="i4030b53016ae4b359db24fcbba098ace_LongTermDebtTermLoanBalancesDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_8b07603b-bf23-48bb-af2b-748d77c6f29c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_8b07603b-bf23-48bb-af2b-748d77c6f29c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_00f7f538-ac3f-4715-94e3-19284416ffe0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_00f7f538-ac3f-4715-94e3-19284416ffe0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_32692983-0ec3-4cf1-80ee-ba29cf4a44e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_32692983-0ec3-4cf1-80ee-ba29cf4a44e3" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_597eb47e-2c7a-4ea2-bb53-bf1756ca7ca9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:to="loc_us-gaap_LongTermDebt_597eb47e-2c7a-4ea2-bb53-bf1756ca7ca9" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_57be7ea0-5372-471a-8b19-11f935535bd0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dea22442-adec-4e54-8fbb-adcf20796f74" xlink:to="loc_us-gaap_DebtInstrumentTable_57be7ea0-5372-471a-8b19-11f935535bd0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_05bb87db-d3c7-4453-af8b-0dc6223bd969" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_57be7ea0-5372-471a-8b19-11f935535bd0" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_05bb87db-d3c7-4453-af8b-0dc6223bd969" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_05bb87db-d3c7-4453-af8b-0dc6223bd969_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_05bb87db-d3c7-4453-af8b-0dc6223bd969" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_05bb87db-d3c7-4453-af8b-0dc6223bd969_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b8c81474-4a7f-47bd-a957-4848e8e867b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_05bb87db-d3c7-4453-af8b-0dc6223bd969" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b8c81474-4a7f-47bd-a957-4848e8e867b8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_b8cc8ade-b7d1-42c5-a094-53a0984f5530" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_b8c81474-4a7f-47bd-a957-4848e8e867b8" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_b8cc8ade-b7d1-42c5-a094-53a0984f5530" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_57be7ea0-5372-471a-8b19-11f935535bd0" xlink:to="loc_us-gaap_DebtInstrumentAxis_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a249fcb0-f1b6-4739-9176-ea2d00891e77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_92a69d5a-2c7b-47f4-84ad-3dcf0bfd941f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a249fcb0-f1b6-4739-9176-ea2d00891e77" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanMember_49c507a2-ffe6-4a9c-a496-c2ea7ad3b628" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a249fcb0-f1b6-4739-9176-ea2d00891e77" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanMember_49c507a2-ffe6-4a9c-a496-c2ea7ad3b628" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTermLoanInterestExpenseDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTermLoanInterestExpenseDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTermLoanInterestExpenseDetails" xlink:type="extended" id="i7dac1d882a784df18a6e385deffa192d_LongTermDebtTermLoanInterestExpenseDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DebtInstrumentCommitmentFees_2cf3158d-460e-48d1-aaf0-ed92a39a8e75" xlink:href="mdxg-20210331.xsd#mdxg_DebtInstrumentCommitmentFees"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_mdxg_DebtInstrumentCommitmentFees_2cf3158d-460e-48d1-aaf0-ed92a39a8e75" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_11c2c960-5d0c-4ea6-8e06-ac9555a36d75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_11c2c960-5d0c-4ea6-8e06-ac9555a36d75" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_57c6723f-0657-4748-9d88-d87742d19a21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_57c6723f-0657-4748-9d88-d87742d19a21" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_fa3d4dd0-c3b7-494e-a6c3-ae14243689a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_fa3d4dd0-c3b7-494e-a6c3-ae14243689a3" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_9e354a21-8462-42ac-9d23-7bc44a9e39ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_us-gaap_InterestExpenseDebt_9e354a21-8462-42ac-9d23-7bc44a9e39ac" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_e95f2a00-429f-432b-9c0b-33ecacc40a6d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a617ce87-5a4a-4473-ac2d-44fd88d9752e" xlink:to="loc_us-gaap_DebtInstrumentTable_e95f2a00-429f-432b-9c0b-33ecacc40a6d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_40542505-3ecb-4594-8d1a-bef09fe52feb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e95f2a00-429f-432b-9c0b-33ecacc40a6d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_40542505-3ecb-4594-8d1a-bef09fe52feb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_40542505-3ecb-4594-8d1a-bef09fe52feb_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_40542505-3ecb-4594-8d1a-bef09fe52feb" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_40542505-3ecb-4594-8d1a-bef09fe52feb_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_fa85cc7c-ddf5-4d43-b183-87120d660e04" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_40542505-3ecb-4594-8d1a-bef09fe52feb" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_fa85cc7c-ddf5-4d43-b183-87120d660e04" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_91c69519-7b73-4089-85c9-c33f90118c23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_fa85cc7c-ddf5-4d43-b183-87120d660e04" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_91c69519-7b73-4089-85c9-c33f90118c23" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_a691f71b-70f0-4cd5-a5e9-340024e4e0f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e95f2a00-429f-432b-9c0b-33ecacc40a6d" xlink:to="loc_us-gaap_DebtInstrumentAxis_a691f71b-70f0-4cd5-a5e9-340024e4e0f7" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a691f71b-70f0-4cd5-a5e9-340024e4e0f7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_a691f71b-70f0-4cd5-a5e9-340024e4e0f7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a691f71b-70f0-4cd5-a5e9-340024e4e0f7_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a5777b7c-dbda-4951-80f8-ec4634521fe6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_a691f71b-70f0-4cd5-a5e9-340024e4e0f7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a5777b7c-dbda-4951-80f8-ec4634521fe6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementTermLoanMember_8839a322-0f6c-4169-82b5-5a96d8641333" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a5777b7c-dbda-4951-80f8-ec4634521fe6" xlink:to="loc_mdxg_HayfinLoanAgreementTermLoanMember_8839a322-0f6c-4169-82b5-5a96d8641333" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_2354f5e4-f728-4e93-9b0a-d69b4c3e5d19" xlink:href="mdxg-20210331.xsd#mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a5777b7c-dbda-4951-80f8-ec4634521fe6" xlink:to="loc_mdxg_HayfinLoanAgreementDelayedDrawTermLoanMember_2354f5e4-f728-4e93-9b0a-d69b4c3e5d19" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TermLoanAgreementMember_65cdcd22-4697-44c0-8067-688964b1e053" xlink:href="mdxg-20210331.xsd#mdxg_TermLoanAgreementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a5777b7c-dbda-4951-80f8-ec4634521fe6" xlink:to="loc_mdxg_TermLoanAgreementMember_65cdcd22-4697-44c0-8067-688964b1e053" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/LongTermDebtTermLoanMaturityDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#LongTermDebtTermLoanMaturityDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/LongTermDebtTermLoanMaturityDetails" xlink:type="extended" id="ie6ef429ca50f44f19db64dc68b7c7ee9_LongTermDebtTermLoanMaturityDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/NetLossPerCommonShare" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NetLossPerCommonShare"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NetLossPerCommonShare" xlink:type="extended" id="i03ef4eafb7c546b79c0862f56764f27a_NetLossPerCommonShare"/>
<link:roleRef roleURI="http://mimedx.com/role/NetLossPerCommonShareTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NetLossPerCommonShareTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NetLossPerCommonShareTables" xlink:type="extended" id="i55d5c39e13184ad5a2b8fe5653d8269b_NetLossPerCommonShareTables"/>
<link:roleRef roleURI="http://mimedx.com/role/NetLossPerCommonShareBasicNetLossPerCommonShareDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NetLossPerCommonShareBasicNetLossPerCommonShareDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NetLossPerCommonShareBasicNetLossPerCommonShareDetails" xlink:type="extended" id="i223acdb5799f431f9820cef0695f49b3_NetLossPerCommonShareBasicNetLossPerCommonShareDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/NetLossPerCommonShareDilutedNetLossPerCommonShareDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#NetLossPerCommonShareDilutedNetLossPerCommonShareDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/NetLossPerCommonShareDilutedNetLossPerCommonShareDetails" xlink:type="extended" id="i232ff67b5a2641f2bb4d65727175639f_NetLossPerCommonShareDilutedNetLossPerCommonShareDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_3735971c-04d4-473f-a8a2-e6881bc4312c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_acddcfb2-fe86-418d-bb54-366165f16610" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_3735971c-04d4-473f-a8a2-e6881bc4312c" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_acddcfb2-fe86-418d-bb54-366165f16610" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_76bcc90c-9a13-4f08-bbf4-d93177fec293" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_3735971c-04d4-473f-a8a2-e6881bc4312c" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_76bcc90c-9a13-4f08-bbf4-d93177fec293" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_6c46aabe-b380-457c-a780-169a313d3153" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_76bcc90c-9a13-4f08-bbf4-d93177fec293" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_6c46aabe-b380-457c-a780-169a313d3153" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6c46aabe-b380-457c-a780-169a313d3153_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_6c46aabe-b380-457c-a780-169a313d3153" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6c46aabe-b380-457c-a780-169a313d3153_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_6c46aabe-b380-457c-a780-169a313d3153" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_7fc71313-4fa0-48aa-9946-cc021e3b513a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_7fc71313-4fa0-48aa-9946-cc021e3b513a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_68daf21e-ec4f-4606-8932-d5031805d57e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:to="loc_us-gaap_RestrictedStockMember_68daf21e-ec4f-4606-8932-d5031805d57e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_bb1a0c04-a340-433e-a70e-01888d5c70bb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_bb1a0c04-a340-433e-a70e-01888d5c70bb" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_69c5dd66-0061-4777-bb5b-4766a18cb18c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:to="loc_us-gaap_EmployeeStockOptionMember_69c5dd66-0061-4777-bb5b-4766a18cb18c" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_9b8cd5fc-7cd8-42f1-b583-87a411349bc1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PerformanceSharesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_b8a66506-72fe-498d-a22c-8d808fc6b517" xlink:to="loc_us-gaap_PerformanceSharesMember_9b8cd5fc-7cd8-42f1-b583-87a411349bc1" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/Equity" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Equity"/>
<link:definitionLink xlink:role="http://mimedx.com/role/Equity" xlink:type="extended" id="i11db6edf1c154c869343b9c3b7adc920_Equity"/>
<link:roleRef roleURI="http://mimedx.com/role/EquityEquityTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#EquityEquityTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/EquityEquityTables" xlink:type="extended" id="id2539508e725429b9974ef5031f8482b_EquityEquityTables"/>
<link:roleRef roleURI="http://mimedx.com/role/EquityNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#EquityNarrativeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/EquityNarrativeDetails" xlink:type="extended" id="i36a81599746f4f9bb6d07998aeac4a82_EquityNarrativeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsPayableLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_4a4cc446-c6b3-4b86-89e1-6a9ada3f062f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_4a4cc446-c6b3-4b86-89e1-6a9ada3f062f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityParOrStatedValuePerShare_4a58f670-8118-4920-801d-6f0a9729e5df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityParOrStatedValuePerShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_us-gaap_TemporaryEquityParOrStatedValuePerShare_4a58f670-8118-4920-801d-6f0a9729e5df" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_ProceedsfromIssuanceofTemporaryEquity_798957c4-ea11-46c2-8c06-8005431aafcc" xlink:href="mdxg-20210331.xsd#mdxg_ProceedsfromIssuanceofTemporaryEquity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_ProceedsfromIssuanceofTemporaryEquity_798957c4-ea11-46c2-8c06-8005431aafcc" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityDividendRatePercentage_e6f17921-4b3d-40e3-a53f-2b299e2ca12c" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityDividendRatePercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityDividendRatePercentage_e6f17921-4b3d-40e3-a53f-2b299e2ca12c" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityConversionPricePerShare_10994358-3f9f-4627-bd82-40bae08e34e0" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityConversionPricePerShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityConversionPricePerShare_10994358-3f9f-4627-bd82-40bae08e34e0" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityConversionRatio_50a4b041-1449-41f7-918c-1c51e16ba35d" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityConversionRatio"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityConversionRatio_50a4b041-1449-41f7-918c-1c51e16ba35d" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTrigger_443c2be3-04d6-4055-942e-1696e7d11487" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTrigger"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTrigger_443c2be3-04d6-4055-942e-1696e7d11487" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityConversionThresholdTradingDays_522cd939-ae0b-4d81-a2ae-6c688f6e3e7d" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityConversionThresholdTradingDays"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityConversionThresholdTradingDays_522cd939-ae0b-4d81-a2ae-6c688f6e3e7d" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityThresholdConsecutiveTradingDays_da929a1e-573d-46ee-a73d-a5920d02d601" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityThresholdConsecutiveTradingDays"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityThresholdConsecutiveTradingDays_da929a1e-573d-46ee-a73d-a5920d02d601" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTriggeronDateofConversion_428a2297-e00c-42df-ab9d-eb6923716667" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTriggeronDateofConversion"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityConversionThresholdPercentageofStockPriceTriggeronDateofConversion_428a2297-e00c-42df-ab9d-eb6923716667" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_NumberofBoardSeatsElectedbyTemporaryEquityHolders_6644a6ed-eff7-4dce-bde6-986b49be54c9" xlink:href="mdxg-20210331.xsd#mdxg_NumberofBoardSeatsElectedbyTemporaryEquityHolders"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_NumberofBoardSeatsElectedbyTemporaryEquityHolders_6644a6ed-eff7-4dce-bde6-986b49be54c9" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityMaximumVotingStockPercentageonAsconvertedBasis_8663efe6-7640-45c5-a6f7-21871860a5b5" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityMaximumVotingStockPercentageonAsconvertedBasis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityMaximumVotingStockPercentageonAsconvertedBasis_8663efe6-7640-45c5-a6f7-21871860a5b5" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityIncreasingrateDividendFeature_2c4e3ebb-38e5-4d54-8db0-bf86620f901b" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityIncreasingrateDividendFeature"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityIncreasingrateDividendFeature_2c4e3ebb-38e5-4d54-8db0-bf86620f901b" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_d3120fae-0a78-48d7-9cdb-02b8b7abff07" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_d3120fae-0a78-48d7-9cdb-02b8b7abff07" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquityAccretedbutUnrecordedDividends_97afb183-0639-4d00-8621-9b07177920a1" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquityAccretedbutUnrecordedDividends"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquityAccretedbutUnrecordedDividends_97afb183-0639-4d00-8621-9b07177920a1" xlink:type="arc" order="14"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_TemporaryEquitySharesIssueduponConversion_5d7e8dc7-7384-4eff-accb-0c2dc49b5cdf" xlink:href="mdxg-20210331.xsd#mdxg_TemporaryEquitySharesIssueduponConversion"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_mdxg_TemporaryEquitySharesIssueduponConversion_5d7e8dc7-7384-4eff-accb-0c2dc49b5cdf" xlink:type="arc" order="15"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableTable_fd7c3f5c-3b5c-496d-8eb9-53f043887b19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsPayableTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DividendsPayableLineItems_7a4f4ccb-3b4a-4c03-84b9-aacf269181cf" xlink:to="loc_us-gaap_DividendsPayableTable_fd7c3f5c-3b5c-496d-8eb9-53f043887b19" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_4a436a25-1317-4ded-9483-b8f2a3d8a008" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DividendsPayableTable_fd7c3f5c-3b5c-496d-8eb9-53f043887b19" xlink:to="loc_us-gaap_StatementClassOfStockAxis_4a436a25-1317-4ded-9483-b8f2a3d8a008" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_4a436a25-1317-4ded-9483-b8f2a3d8a008_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4a436a25-1317-4ded-9483-b8f2a3d8a008" xlink:to="loc_us-gaap_ClassOfStockDomain_4a436a25-1317-4ded-9483-b8f2a3d8a008_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_456b020c-8999-4738-8963-18730342a5e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4a436a25-1317-4ded-9483-b8f2a3d8a008" xlink:to="loc_us-gaap_ClassOfStockDomain_456b020c-8999-4738-8963-18730342a5e6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredClassBMember_3ed7189e-53a5-4064-86c0-63c4de3d1b99" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredClassBMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_456b020c-8999-4738-8963-18730342a5e6" xlink:to="loc_us-gaap_PreferredClassBMember_3ed7189e-53a5-4064-86c0-63c4de3d1b99" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_43727502-1223-43d2-a8fb-d74995bdfcd1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_456b020c-8999-4738-8963-18730342a5e6" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_43727502-1223-43d2-a8fb-d74995bdfcd1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsAxis_adf84ed1-67c0-484a-b20e-3b5a155985e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DividendsPayableTable_fd7c3f5c-3b5c-496d-8eb9-53f043887b19" xlink:to="loc_us-gaap_DividendsAxis_adf84ed1-67c0-484a-b20e-3b5a155985e6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsDomain_adf84ed1-67c0-484a-b20e-3b5a155985e6_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DividendsAxis_adf84ed1-67c0-484a-b20e-3b5a155985e6" xlink:to="loc_us-gaap_DividendsDomain_adf84ed1-67c0-484a-b20e-3b5a155985e6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsDomain_fa49c003-1d6a-46fc-9df3-eb0b28bdad26" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DividendsAxis_adf84ed1-67c0-484a-b20e-3b5a155985e6" xlink:to="loc_us-gaap_DividendsDomain_fa49c003-1d6a-46fc-9df3-eb0b28bdad26" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_DiscountedDividendRatepriortoQuarterlyDividendPaymentendingonJune302021Member_026fe065-ffdd-4640-b73c-56300858ef79" xlink:href="mdxg-20210331.xsd#mdxg_DiscountedDividendRatepriortoQuarterlyDividendPaymentendingonJune302021Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsDomain_fa49c003-1d6a-46fc-9df3-eb0b28bdad26" xlink:to="loc_mdxg_DiscountedDividendRatepriortoQuarterlyDividendPaymentendingonJune302021Member_026fe065-ffdd-4640-b73c-56300858ef79" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_PerpetualDividendRateafterQuarterlyDividendPaymentendingonJune302021Member_457488ca-2177-40f5-9fb9-8c2b851de739" xlink:href="mdxg-20210331.xsd#mdxg_PerpetualDividendRateafterQuarterlyDividendPaymentendingonJune302021Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsDomain_fa49c003-1d6a-46fc-9df3-eb0b28bdad26" xlink:to="loc_mdxg_PerpetualDividendRateafterQuarterlyDividendPaymentendingonJune302021Member_457488ca-2177-40f5-9fb9-8c2b851de739" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/EquityChangesinSeriesBPreferredStockDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#EquityChangesinSeriesBPreferredStockDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/EquityChangesinSeriesBPreferredStockDetails" xlink:type="extended" id="i5432aaad109c4641be467fd48da088fb_EquityChangesinSeriesBPreferredStockDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_bbbe3c61-3385-4b16-8dbb-a5443ec458a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5f51e453-f9cf-4682-b9d5-0f5ff3cf9735" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_bbbe3c61-3385-4b16-8dbb-a5443ec458a6" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5f51e453-f9cf-4682-b9d5-0f5ff3cf9735" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_f2c065a9-d2a6-4242-b9c5-9e8284c25517" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5f51e453-f9cf-4682-b9d5-0f5ff3cf9735" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_f2c065a9-d2a6-4242-b9c5-9e8284c25517" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_c7ea4cbd-7454-4f22-808f-6d61fb8a20b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_8caa77c6-d10c-47d4-8976-e3793b3e1798" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5f51e453-f9cf-4682-b9d5-0f5ff3cf9735" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_8caa77c6-d10c-47d4-8976-e3793b3e1798" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_018bb653-e824-4db2-9e6a-f96d32e4b332" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5f51e453-f9cf-4682-b9d5-0f5ff3cf9735" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalDividendsInExcessOfRetainedEarnings_018bb653-e824-4db2-9e6a-f96d32e4b332" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_64007187-4f97-4f93-a60a-70466c42f8e2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_0442cdb0-647c-4284-bb30-5963d090f738" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_bbbe3c61-3385-4b16-8dbb-a5443ec458a6" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_0442cdb0-647c-4284-bb30-5963d090f738" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5b0630e5-4697-4a14-b766-eb3f0779f3fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_0442cdb0-647c-4284-bb30-5963d090f738" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5b0630e5-4697-4a14-b766-eb3f0779f3fe" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5b0630e5-4697-4a14-b766-eb3f0779f3fe_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5b0630e5-4697-4a14-b766-eb3f0779f3fe" xlink:to="loc_us-gaap_ClassOfStockDomain_5b0630e5-4697-4a14-b766-eb3f0779f3fe_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_91d88904-a7ad-42ae-8d4b-e0302bcdc9be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5b0630e5-4697-4a14-b766-eb3f0779f3fe" xlink:to="loc_us-gaap_ClassOfStockDomain_91d88904-a7ad-42ae-8d4b-e0302bcdc9be" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_303b62d0-481b-43a9-bdc8-d1e9e8edb08b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeriesBPreferredStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_91d88904-a7ad-42ae-8d4b-e0302bcdc9be" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_303b62d0-481b-43a9-bdc8-d1e9e8edb08b" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/Incometaxes" xlink:type="simple" xlink:href="mdxg-20210331.xsd#Incometaxes"/>
<link:definitionLink xlink:role="http://mimedx.com/role/Incometaxes" xlink:type="extended" id="i1fc3129ed68842298929bb7f6c85a566_Incometaxes"/>
<link:roleRef roleURI="http://mimedx.com/role/IncometaxesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#IncometaxesDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/IncometaxesDetails" xlink:type="extended" id="i919bcd343b5f4047bfdfa85092820ed2_IncometaxesDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemLineItems_5820c3a8-f452-4d61-ab7f-497ca363b077" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_72e3bf6c-e812-48d8-88ae-d667767c220e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_5820c3a8-f452-4d61-ab7f-497ca363b077" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_72e3bf6c-e812-48d8-88ae-d667767c220e" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemTable_53df4152-35c9-4fed-bb0e-bd12460a286f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_5820c3a8-f452-4d61-ab7f-497ca363b077" xlink:to="loc_us-gaap_UnusualOrInfrequentItemTable_53df4152-35c9-4fed-bb0e-bd12460a286f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_6e732e36-109c-455a-a656-7181b24873a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_53df4152-35c9-4fed-bb0e-bd12460a286f" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_6e732e36-109c-455a-a656-7181b24873a6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_6e732e36-109c-455a-a656-7181b24873a6_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_6e732e36-109c-455a-a656-7181b24873a6" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_6e732e36-109c-455a-a656-7181b24873a6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_e7586758-499a-4308-aa33-c91eda9eae97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_6e732e36-109c-455a-a656-7181b24873a6" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_e7586758-499a-4308-aa33-c91eda9eae97" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_CARESActMember_01313f16-5d63-44cd-b570-a7063d3c3d82" xlink:href="mdxg-20210331.xsd#mdxg_CARESActMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_e7586758-499a-4308-aa33-c91eda9eae97" xlink:to="loc_mdxg_CARESActMember_01313f16-5d63-44cd-b570-a7063d3c3d82" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivities" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivities"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivities" xlink:type="extended" id="i8460ecd67a1c4514aa36b3dfdaaac336_SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivities"/>
<link:roleRef roleURI="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesTables" xlink:type="extended" id="i2e692807bf08432dab98df36439f4465_SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesTables"/>
<link:roleRef roleURI="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesDetails" xlink:type="extended" id="ib7ba8f8405f54f619b368ccab47eca9b_SupplementalDisclosureofCashFlowandNonCashInvestingandFinancingActivitiesDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/ContractualCommitmentsandContingencies" xlink:type="simple" xlink:href="mdxg-20210331.xsd#ContractualCommitmentsandContingencies"/>
<link:definitionLink xlink:role="http://mimedx.com/role/ContractualCommitmentsandContingencies" xlink:type="extended" id="i0c8a93b7b1064be190804a6e5da61148_ContractualCommitmentsandContingencies"/>
<link:roleRef roleURI="http://mimedx.com/role/ContractualCommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#ContractualCommitmentsandContingenciesNarrativeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/ContractualCommitmentsandContingenciesNarrativeDetails" xlink:type="extended" id="i0bca896757e24453899d3d66145dae05_ContractualCommitmentsandContingenciesNarrativeDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/RevenueDatabyCustomerType" xlink:type="simple" xlink:href="mdxg-20210331.xsd#RevenueDatabyCustomerType"/>
<link:definitionLink xlink:role="http://mimedx.com/role/RevenueDatabyCustomerType" xlink:type="extended" id="i87622f0b552f4d2bacfa4b1d05e1b622_RevenueDatabyCustomerType"/>
<link:roleRef roleURI="http://mimedx.com/role/RevenueDatabyCustomerTypeTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#RevenueDatabyCustomerTypeTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/RevenueDatabyCustomerTypeTables" xlink:type="extended" id="i4bce33a3a7f442dfaf968d737e4319dc_RevenueDatabyCustomerTypeTables"/>
<link:roleRef roleURI="http://mimedx.com/role/RevenueDatabyCustomerTypeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#RevenueDatabyCustomerTypeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/RevenueDatabyCustomerTypeDetails" xlink:type="extended" id="i0daa820ec3e24f299db977e50938e57a_RevenueDatabyCustomerTypeDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_b0a2a988-1d2a-4d1b-ac51-12cb5b2e7607" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_mdxg_NumberofDistributionChannels_9feca486-fb06-4d61-855f-52c1cd873b4f" xlink:href="mdxg-20210331.xsd#mdxg_NumberofDistributionChannels"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_b0a2a988-1d2a-4d1b-ac51-12cb5b2e7607" xlink:to="loc_mdxg_NumberofDistributionChannels_9feca486-fb06-4d61-855f-52c1cd873b4f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0c616844-3b29-4d5f-97bb-95375763e3d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_b0a2a988-1d2a-4d1b-ac51-12cb5b2e7607" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0c616844-3b29-4d5f-97bb-95375763e3d5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_ebdace13-b3b3-44cb-a89d-2e40731e8d27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_b0a2a988-1d2a-4d1b-ac51-12cb5b2e7607" xlink:to="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_ebdace13-b3b3-44cb-a89d-2e40731e8d27" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelAxis_37677353-ef26-4cbd-b28f-9a961f6cdb93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_ebdace13-b3b3-44cb-a89d-2e40731e8d27" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelAxis_37677353-ef26-4cbd-b28f-9a961f6cdb93" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelDomain_37677353-ef26-4cbd-b28f-9a961f6cdb93_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelAxis_37677353-ef26-4cbd-b28f-9a961f6cdb93" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelDomain_37677353-ef26-4cbd-b28f-9a961f6cdb93_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelDomain_96bfe0e0-e9bb-4731-8b04-7d7759471381" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelAxis_37677353-ef26-4cbd-b28f-9a961f6cdb93" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelDomain_96bfe0e0-e9bb-4731-8b04-7d7759471381" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesChannelDirectlyToConsumerMember_31aa5c2b-3526-4950-b034-18ce0349b264" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SalesChannelDirectlyToConsumerMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_96bfe0e0-e9bb-4731-8b04-7d7759471381" xlink:to="loc_us-gaap_SalesChannelDirectlyToConsumerMember_31aa5c2b-3526-4950-b034-18ce0349b264" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesChannelThroughIntermediaryMember_1bd2f964-c041-4522-a3c1-3e75ee008fde" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SalesChannelThroughIntermediaryMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_96bfe0e0-e9bb-4731-8b04-7d7759471381" xlink:to="loc_us-gaap_SalesChannelThroughIntermediaryMember_1bd2f964-c041-4522-a3c1-3e75ee008fde" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/SharebasedCompensation" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SharebasedCompensation"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SharebasedCompensation" xlink:type="extended" id="i03d13a46a9fc4061b4c2c32187dae4bf_SharebasedCompensation"/>
<link:roleRef roleURI="http://mimedx.com/role/SharebasedCompensationTables" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SharebasedCompensationTables"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SharebasedCompensationTables" xlink:type="extended" id="i06dcbeddb6964eb9920a6d6b3c299e27_SharebasedCompensationTables"/>
<link:roleRef roleURI="http://mimedx.com/role/SharebasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SharebasedCompensationNarrativeDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SharebasedCompensationNarrativeDetails" xlink:type="extended" id="i1e5551600e244036a7b71aa0ff87e239_SharebasedCompensationNarrativeDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/SharebasedCompensationRestrictedStockAwardsDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SharebasedCompensationRestrictedStockAwardsDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SharebasedCompensationRestrictedStockAwardsDetails" xlink:type="extended" id="ia10bd930dab1489e8d7f52ae752bb52d_SharebasedCompensationRestrictedStockAwardsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acf625ad-70d8-43e7-90ff-68a85092f1bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acf625ad-70d8-43e7-90ff-68a85092f1bc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_dfc0b173-4564-4583-82d3-84ea9fa843da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_dfc0b173-4564-4583-82d3-84ea9fa843da" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_06d63c5b-69a0-4fe7-b2a5-abe9e1794a21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_06d63c5b-69a0-4fe7-b2a5-abe9e1794a21" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_9d675a42-1382-40ba-8ee8-0095586e6755" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_9d675a42-1382-40ba-8ee8-0095586e6755" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_3f7c10f1-b240-4b27-9f4b-51cd8f1ac1c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_0ad69bf9-5986-4030-8e9f-5161e653efcc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_3f7c10f1-b240-4b27-9f4b-51cd8f1ac1c9" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f705cce4-7e98-400f-9bf1-13764604dad5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acf625ad-70d8-43e7-90ff-68a85092f1bc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_f7b66194-f5bc-420d-8e7a-02ce6a891170" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_f7b66194-f5bc-420d-8e7a-02ce6a891170" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b88c145b-5ce2-4679-ad0c-9c09cbd2533d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b88c145b-5ce2-4679-ad0c-9c09cbd2533d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_89480631-209f-4056-bbf9-827a3f4051d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_89480631-209f-4056-bbf9-827a3f4051d4" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_73bd39ee-ce59-4e54-ae19-2443ade875dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fe1eb426-7b39-4e1d-80fd-bbc214aa04ec" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_73bd39ee-ce59-4e54-ae19-2443ade875dc" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_3c28fc88-df8a-493b-bbca-432ad236a2a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7336cd47-dd03-4bce-83a8-0299e6f27704" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acf625ad-70d8-43e7-90ff-68a85092f1bc" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7336cd47-dd03-4bce-83a8-0299e6f27704" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1f6f4d72-f236-443a-9ff5-3b6f2b318d60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7336cd47-dd03-4bce-83a8-0299e6f27704" xlink:to="loc_us-gaap_AwardTypeAxis_1f6f4d72-f236-443a-9ff5-3b6f2b318d60" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1f6f4d72-f236-443a-9ff5-3b6f2b318d60_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_1f6f4d72-f236-443a-9ff5-3b6f2b318d60" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1f6f4d72-f236-443a-9ff5-3b6f2b318d60_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4be4acb1-5461-455d-bbfc-7d61a2e37703" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_1f6f4d72-f236-443a-9ff5-3b6f2b318d60" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4be4acb1-5461-455d-bbfc-7d61a2e37703" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_9d645ffd-5eb2-40bb-8b69-fa0d28235309" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4be4acb1-5461-455d-bbfc-7d61a2e37703" xlink:to="loc_us-gaap_RestrictedStockMember_9d645ffd-5eb2-40bb-8b69-fa0d28235309" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_44035bba-1bbc-4c2e-a866-34601a1a3775" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4be4acb1-5461-455d-bbfc-7d61a2e37703" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_44035bba-1bbc-4c2e-a866-34601a1a3775" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_7eb85e7d-e5d9-4a87-841a-ed37b4dcf6a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PerformanceSharesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4be4acb1-5461-455d-bbfc-7d61a2e37703" xlink:to="loc_us-gaap_PerformanceSharesMember_7eb85e7d-e5d9-4a87-841a-ed37b4dcf6a8" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://mimedx.com/role/SharebasedCompensationStockIncentivePlansDetails" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SharebasedCompensationStockIncentivePlansDetails"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SharebasedCompensationStockIncentivePlansDetails" xlink:type="extended" id="i70019f7518984a41ba2c337a642033d6_SharebasedCompensationStockIncentivePlansDetails"/>
<link:roleRef roleURI="http://mimedx.com/role/SubsequentEvents" xlink:type="simple" xlink:href="mdxg-20210331.xsd#SubsequentEvents"/>
<link:definitionLink xlink:role="http://mimedx.com/role/SubsequentEvents" xlink:type="extended" id="i3564605ab0b14a618da8c83dac888428_SubsequentEvents"/>
</link:linkbase>


1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/27/21  Mimedx Group, Inc.                S-3                    8:2.2M                                   Donnelley … Solutions/FA


3 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/21/21  Mimedx Group, Inc.                8-K:5,9     4/19/21   12:465K                                   Donnelley … Solutions/FA
 3/30/21  Mimedx Group, Inc.                8-K:4,9     3/25/21   13:178K
 3/08/21  Mimedx Group, Inc.                10-K       12/31/20  111:12M
Top
Filing Submission 0001376339-21-000032   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Tue., May 14, 7:05:06.2am ET