SEC Info - Apollo Medical Holdings, Inc. - ‘10-K’ for 12/31/19

SEC Info℠

Home

My Interests

Help

Please Sign In

Apollo Medical Holdings, Inc. – ‘10-K’ for 12/31/19 – ‘EX-101.DEF’

On: Monday, 3/16/20, at 4:11pm ET · For: 12/31/19 · Accession #: 1628280-20-3626 · File #: 1-37392

Previous ‘10-K’: ‘10-K’ on 3/18/19 for 12/31/18 · Next: ‘10-K’ on 3/15/21 for 12/31/20 · Latest: ‘10-K’ on 2/29/24 for 12/31/23 · 16 References:

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/16/20  Apollo Medical Holdings, Inc.     10-K       12/31/19  116:18M                                    Workiva Inc Wde… FA01/FA

Annual Report — Form 10-K — Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.55M 
 2: EX-4.10     Instrument Defining the Rights of Security Holders  HTML     41K 
 3: EX-14.1     Code of Ethics                                      HTML     49K 
 4: EX-21.1     Subsidiaries List                                   HTML     37K 
 5: EX-23.1     Consent of Experts or Counsel                       HTML     34K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     42K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     42K 
 8: EX-31.3     Certification -- §302 - SOA'02                      HTML     42K 
 9: EX-32       Certification -- §906 - SOA'02                      HTML     42K 
114: R1          Document and Entity Information                     HTML     67K  
51: R2          Consolidated Balance Sheets                         HTML    198K 
37: R3          Consolidated Balance Sheets (Parenthetical)         HTML     56K 
76: R4          Consolidated Statements of Income                   HTML    128K 
113: R5          Consolidated Statements of Mezzanine and            HTML    141K  
                Shareholders' Equity                                             
50: R6          Consolidated Statements of Mezzanine and            HTML     35K 
                Shareholders' Equity (Parenthetical)                             
36: R7          Consolidated Statements of Cash Flows               HTML    230K 
74: R8          Consolidated Statements of Cash Flows               HTML     36K 
                (Parenthetical)                                                  
116: R9          Description of Business                             HTML     62K  
78: R10         Basis of Presentation and Summary of Significant    HTML    236K 
                Accounting Policies                                              
92: R11         Business Combination and Goodwill                   HTML    137K 
58: R12         Land, Property and Equipment, Net                   HTML     56K 
19: R13         Intangible Assets, Net                              HTML    133K 
79: R14         Investments in Other Entities                       HTML    214K 
94: R15         Loans Receivable and Loans Receivable - Related     HTML     44K 
                Parties                                                          
59: R16         Accounts Payable and Accrued Expenses               HTML     53K 
20: R17         Medical Liabilities                                 HTML     54K 
80: R18         Credit Facility, Bank Loan and Lines of Credit -    HTML     94K 
                Related Party                                                    
91: R19         Income Taxes                                        HTML    133K 
49: R20         Mezzanine and Shareholders' Equity                  HTML    269K 
35: R21         Commitments and Contingencies                       HTML     49K 
75: R22         Related Party Transactions                          HTML     60K 
112: R23         Employee Benefit Plan                               HTML     37K  
52: R24         Revenue Recognition                                 HTML     39K 
38: R25         Earnings Per Share                                  HTML     71K 
77: R26         Variable Interest Entities (VIEs)                   HTML    117K 
115: R27         Leases                                              HTML    151K  
48: R28         Basis of Presentation and Summary of Significant    HTML    262K 
                Accounting Policies (Policies)                                   
39: R29         Basis of Presentation and Summary of Significant    HTML    121K 
                Accounting Policies (Tables)                                     
18: R30         Business Combination and Goodwill (Tables)          HTML    124K 
55: R31         Land, Property and Equipment, Net (Tables)          HTML     54K 
96: R32         Intangible Assets, Net (Tables)                     HTML    225K 
82: R33         Investments in Other Entities (Tables)              HTML    179K 
17: R34         Accounts Payable and Accrued Expenses (Tables)      HTML     53K 
54: R35         Medical Liabilities (Tables)                        HTML     53K 
95: R36         Credit Facility, Bank Loan and Lines of Credit -    HTML     52K 
                Related Party (Tables)                                           
81: R37         Income Taxes (Tables)                               HTML    129K 
16: R38         Mezzanine and Shareholders' Equity (Tables)         HTML    229K 
56: R39         Related Party Transactions (Tables)                 HTML     44K 
34: R40         Earnings Per Share (Tables)                         HTML     70K 
46: R41         Variable Interest Entities (VIEs) (Tables)          HTML    120K 
106: R42         Leases (Tables)                                     HTML    128K  
68: R43         Description of Business - Additional Information    HTML    175K 
                (Details)                                                        
33: R44         Basis of Presentation and Summary of Significant    HTML    138K 
                Accounting Policies - Additional Information                     
                (Details)                                                        
45: R45         Basis of Presentation and Summary of Significant    HTML     41K 
                Accounting Policies - Additional Information,                    
                Performance Obligation (Details)                                 
105: R46         Basis of Presentation and Summary of Significant    HTML     46K  
                Accounting Policies - Disaggregation of Revenue by               
                Payor Type (Details)                                             
67: R47         Basis of Presentation and Summary of Significant    HTML     56K 
                Accounting Policies - Contributions to Revenue and               
                Receivables by Payor (Details)                                   
32: R48         Basis of Presentation and Summary of Significant    HTML     53K 
                Accounting Policies - Carrying Amounts and Fair                  
                Values of Company's Financial Instruments                        
                (Details)                                                        
47: R49         Business Combination and Goodwill - Additional      HTML    177K 
                Information (Details)                                            
65: R50         Business Combination and Goodwill - Total Purchase  HTML     48K 
                Consideration (Details)                                          
25: R51         Business Combination and Goodwill - Calculated      HTML     41K 
                Based on Number of Shares of Combined Company                    
                Pre-Merger (Details)                                             
83: R52         Business Combination and Goodwill - Assumption of   HTML    118K 
                Identifiable Assets Acquired and Liabilities                     
                (Details)                                                        
97: R53         Business Combination and Goodwill - Pro Forma       HTML     55K 
                Combined Historical Results (Details)                            
66: R54         Business Combination and Goodwill - Pro Forma       HTML     46K 
                Financial Information All 2019 Acquisitions                      
                (Details)                                                        
26: R55         Business Combination and Goodwill - Goodwill Roll   HTML     45K 
                Forward (Details)                                                
84: R56         Land, Property and Equipment, Net - Schedule of     HTML     70K 
                Land, Property and Equipment, Net (Details)                      
98: R57         Land, Property and Equipment, Net - Additional      HTML     38K 
                Information (Details)                                            
64: R58         Intangible Assets, Net - Schedule of Intangible     HTML     87K 
                Assets (Details)                                                 
27: R59         Intangible Assets, Net - Additional Information     HTML     44K 
                (Details)                                                        
70: R60         Intangible Assets, Net - Schedule of Future         HTML     50K 
                Amortization Expense (Details)                                   
109: R61         Investments in Other Entities - Equity Method       HTML     55K  
                (Details)                                                        
41: R62         Investments in Other Entities - Additional          HTML    329K 
                Information (Details)                                            
29: R63         Investments in Other Entities - Summarized Balance  HTML    106K 
                Sheets and Statements of Income (Details)                        
71: R64         Loans Receivable and Loans Receivable - Related     HTML     91K 
                Parties - Additional Information (Details)                       
110: R65         Accounts Payable and Accrued Expenses - Schedule    HTML     54K  
                of Accounts Payable and Accrued Expenses (Details)               
42: R66         Medical Liabilities - Schedule of Medical           HTML     50K 
                Liabilities (Details)                                            
30: R67         Credit Facility, Bank Loan and Lines of Credit -    HTML     52K 
                Related Party - Schedule of Credit Facility                      
                Information (Details)                                            
73: R68         Credit Facility, Bank Loan and Lines of Credit -    HTML     52K 
                Related Party - Schedule of Maturities (Details)                 
107: R69         Credit Facility, Bank Loan and Lines of Credit -    HTML    222K  
                Related Party - Additional Information (Detail)                  
101: R70         Income Taxes - Income Tax Provision (Benefit)       HTML     59K  
                (Details)                                                        
89: R71         Income Taxes - Additional Information (Details)     HTML     66K 
23: R72         Income Taxes - Deferred Tax Assets (Liabilities)    HTML     94K 
                (Details)                                                        
62: R73         Income Taxes - Provision for Income Taxes           HTML     66K 
                (Details)                                                        
100: R74         Mezzanine and Shareholders' Equity - APC (Details)  HTML     64K  
88: R75         Mezzanine and Shareholders' Equity - Shareholders'  HTML    169K 
                Equity (Details)                                                 
22: R76         Mezzanine and Shareholders' Equity - Equity         HTML    116K 
                Incentive Plans (Details)                                        
61: R77         Mezzanine and Shareholders' Equity - Summary of     HTML    162K 
                Stock Option Activity Under Black-Scholes Option                 
                (Details)                                                        
103: R78         Mezzanine and Shareholders' Equity - Schedule of    HTML     78K  
                Stock Options Activity (Details)                                 
85: R79         Mezzanine and Shareholders' Equity - Summary of     HTML     40K 
                Remaining Unrecognized Share based Compensation of               
                Stock Option (Details)                                           
102: R80         Mezzanine and Shareholders' Equity - Warrants       HTML     57K  
                Narrative (Details)                                              
90: R81         Mezzanine and Shareholders' Equity - Summary of     HTML     71K 
                Warrants (Details)                                               
24: R82         Mezzanine and Shareholders' Equity - Warrants       HTML     65K 
                (Details)                                                        
63: R83         Mezzanine and Shareholders' Equity - Dividends and  HTML     63K 
                Treasury Stock (Details)                                         
99: R84         Commitments and Contingencies - Additional          HTML     70K 
                Information (Details)                                            
87: R85         Related Party Transactions - Additional             HTML     94K 
                Information (Details)                                            
21: R86         Related Party Transactions - Schedule of Related    HTML     46K 
                Party Transactions (Details)                                     
60: R87         Employee Benefit Plan - Additional Information      HTML     39K 
                (Details)                                                        
104: R88         Revenue Recognition - Additional Information        HTML     45K  
                (Details)                                                        
86: R89         Earnings Per Share - Additional Information         HTML     44K 
                (Details)                                                        
69: R90         Earnings Per Share - Basic Net Income (loss) Per    HTML     50K 
                Share is Calculated Using Weighted Average Number                
                of Shares (Details)                                              
108: R91         Earnings Per Share - Summary of Shares Included in  HTML     55K  
                Diluted Earnings Per Share (Details)                             
40: R92         Variable Interest Entities (VIEs) - Eliminated      HTML    171K 
                Upon Consolidation Included In Accompanying                      
                Consolidated Balance Sheets (Details)                            
28: R93         Leases - Additional information (Details)           HTML     60K 
72: R94         Leases - Components of Lease Expense (Details)      HTML     48K 
111: R95         Leases - Other Information Related to Leases        HTML     61K  
                (Details)                                                        
43: R96         Leases - Future Minimum Payments Under              HTML     84K 
                Non-cancelable Leases After Adoption of 842                      
                (Details)                                                        
31: R97         Leases - Future Minimum Payments Under              HTML     72K 
                Non-cancelable Leases Prior to Adoption of 842                   
                (Details)                                                        
44: R9999       Uncategorized Items - ameh-20191231.xml             HTML     51K 
57: XML         IDEA XML File -- Filing Summary                      XML    214K 
53: EXCEL       IDEA Workbook of Financial Reports                  XLSX    174K 
10: EX-101.INS  XBRL Instance -- ameh-20191231                       XML   5.14M 
12: EX-101.CAL  XBRL Calculations -- ameh-20191231_cal               XML    456K 
13: EX-101.DEF  XBRL Definitions -- ameh-20191231_def                XML   1.74M 
14: EX-101.LAB  XBRL Labels -- ameh-20191231_lab                     XML   3.39M 
15: EX-101.PRE  XBRL Presentations -- ameh-20191231_pre              XML   2.15M 
11: EX-101.SCH  XBRL Schema -- ameh-20191231                         XSD    357K 
93: ZIP         XBRL Zipped Folder -- 0001628280-20-003626-xbrl      Zip    531K

‘EX-101.DEF’ — XBRL Definitions — ameh-20191231_def

This Exhibit is an XBRL XML File.

<?xml version="1.0" encoding="windows-1252"?>

<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">

<link:roleRef roleURI="http://www.apollomed.net/role/AccountsPayableAndAccruedExpenses" xlink:href="ameh-20191231.xsd#AccountsPayableAndAccruedExpenses" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/AccountsPayableAndAccruedExpensesScheduleOfAccountsPayableAndAccruedExpensesDetails" xlink:href="ameh-20191231.xsd#AccountsPayableAndAccruedExpensesScheduleOfAccountsPayableAndAccruedExpensesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/AccountsPayableAndAccruedExpensesTables" xlink:href="ameh-20191231.xsd#AccountsPayableAndAccruedExpensesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationPerformanceObligationDetails" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationPerformanceObligationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesCarryingAmountsAndFairValuesOfCompanysFinancialInstrumentsDetails" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesCarryingAmountsAndFairValuesOfCompanysFinancialInstrumentsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesContributionsToRevenueAndReceivablesByPayorDetails" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesContributionsToRevenueAndReceivablesByPayorDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDisaggregationOfRevenueByPayorTypeDetails" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDisaggregationOfRevenueByPayorTypeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:href="ameh-20191231.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwill" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwill" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillAssumptionOfIdentifiableAssetsAcquiredAndLiabilitiesDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillAssumptionOfIdentifiableAssetsAcquiredAndLiabilitiesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillCalculatedBasedOnNumberOfSharesOfCombinedCompanyPreMergerDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillCalculatedBasedOnNumberOfSharesOfCombinedCompanyPreMergerDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillGoodwillRollForwardDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillGoodwillRollForwardDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillProFormaCombinedHistoricalResultsDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillProFormaCombinedHistoricalResultsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillProFormaFinancialInformationAll2019AcquisitionsDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillProFormaFinancialInformationAll2019AcquisitionsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillTables" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/BusinessCombinationAndGoodwillTotalPurchaseConsiderationDetails" xlink:href="ameh-20191231.xsd#BusinessCombinationAndGoodwillTotalPurchaseConsiderationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CommitmentsAndContingencies" xlink:href="ameh-20191231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CommitmentsAndContingenciesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#CommitmentsAndContingenciesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedBalanceSheets" xlink:href="ameh-20191231.xsd#ConsolidatedBalanceSheets" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="ameh-20191231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedStatementsOfCashFlows" xlink:href="ameh-20191231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:href="ameh-20191231.xsd#ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedStatementsOfIncome" xlink:href="ameh-20191231.xsd#ConsolidatedStatementsOfIncome" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedStatementsOfMezzanineAndShareholdersEquity" xlink:href="ameh-20191231.xsd#ConsolidatedStatementsOfMezzanineAndShareholdersEquity" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/ConsolidatedStatementsOfMezzanineAndShareholdersEquityParenthetical" xlink:href="ameh-20191231.xsd#ConsolidatedStatementsOfMezzanineAndShareholdersEquityParenthetical" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedParty" xlink:href="ameh-20191231.xsd#CreditFacilityBankLoanAndLinesOfCreditRelatedParty" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyAdditionalInformationDetail" xlink:href="ameh-20191231.xsd#CreditFacilityBankLoanAndLinesOfCreditRelatedPartyAdditionalInformationDetail" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfCreditFacilityInformationDetails" xlink:href="ameh-20191231.xsd#CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfCreditFacilityInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfMaturitiesDetails" xlink:href="ameh-20191231.xsd#CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfMaturitiesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyTables" xlink:href="ameh-20191231.xsd#CreditFacilityBankLoanAndLinesOfCreditRelatedPartyTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/DescriptionOfBusiness" xlink:href="ameh-20191231.xsd#DescriptionOfBusiness" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/DescriptionOfBusinessAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#DescriptionOfBusinessAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/DocumentAndEntityInformation" xlink:href="ameh-20191231.xsd#DocumentAndEntityInformation" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EarningsPerShare" xlink:href="ameh-20191231.xsd#EarningsPerShare" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EarningsPerShareAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#EarningsPerShareAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EarningsPerShareBasicNetIncomeLossPerShareIsCalculatedUsingWeightedAverageNumberOfSharesDetails" xlink:href="ameh-20191231.xsd#EarningsPerShareBasicNetIncomeLossPerShareIsCalculatedUsingWeightedAverageNumberOfSharesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EarningsPerShareSummaryOfSharesIncludedInDilutedEarningsPerShareDetails" xlink:href="ameh-20191231.xsd#EarningsPerShareSummaryOfSharesIncludedInDilutedEarningsPerShareDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EarningsPerShareTables" xlink:href="ameh-20191231.xsd#EarningsPerShareTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EmployeeBenefitPlan" xlink:href="ameh-20191231.xsd#EmployeeBenefitPlan" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/EmployeeBenefitPlanAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#EmployeeBenefitPlanAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxes" xlink:href="ameh-20191231.xsd#IncomeTaxes" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#IncomeTaxesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxesDeferredTaxAssetsLiabilitiesDetails" xlink:href="ameh-20191231.xsd#IncomeTaxesDeferredTaxAssetsLiabilitiesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxesIncomeTaxProvisionBenefitDetails" xlink:href="ameh-20191231.xsd#IncomeTaxesIncomeTaxProvisionBenefitDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxesProvisionForIncomeTaxesDetails" xlink:href="ameh-20191231.xsd#IncomeTaxesProvisionForIncomeTaxesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IncomeTaxesTables" xlink:href="ameh-20191231.xsd#IncomeTaxesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IntangibleAssetsNet" xlink:href="ameh-20191231.xsd#IntangibleAssetsNet" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IntangibleAssetsNetAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#IntangibleAssetsNetAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IntangibleAssetsNetScheduleOfFutureAmortizationExpenseDetails" xlink:href="ameh-20191231.xsd#IntangibleAssetsNetScheduleOfFutureAmortizationExpenseDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IntangibleAssetsNetScheduleOfIntangibleAssetsDetails" xlink:href="ameh-20191231.xsd#IntangibleAssetsNetScheduleOfIntangibleAssetsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/IntangibleAssetsNetTables" xlink:href="ameh-20191231.xsd#IntangibleAssetsNetTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/InvestmentsInOtherEntities" xlink:href="ameh-20191231.xsd#InvestmentsInOtherEntities" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/InvestmentsInOtherEntitiesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#InvestmentsInOtherEntitiesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/InvestmentsInOtherEntitiesEquityMethodDetails" xlink:href="ameh-20191231.xsd#InvestmentsInOtherEntitiesEquityMethodDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/InvestmentsInOtherEntitiesSummarizedBalanceSheetsAndStatementsOfIncomeDetails" xlink:href="ameh-20191231.xsd#InvestmentsInOtherEntitiesSummarizedBalanceSheetsAndStatementsOfIncomeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/InvestmentsInOtherEntitiesTables" xlink:href="ameh-20191231.xsd#InvestmentsInOtherEntitiesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LandPropertyAndEquipmentNet" xlink:href="ameh-20191231.xsd#LandPropertyAndEquipmentNet" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LandPropertyAndEquipmentNetAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#LandPropertyAndEquipmentNetAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LandPropertyAndEquipmentNetScheduleOfLandPropertyAndEquipmentNetDetails" xlink:href="ameh-20191231.xsd#LandPropertyAndEquipmentNetScheduleOfLandPropertyAndEquipmentNetDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LandPropertyAndEquipmentNetTables" xlink:href="ameh-20191231.xsd#LandPropertyAndEquipmentNetTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/Leases" xlink:href="ameh-20191231.xsd#Leases" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#LeasesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesComponentsOfLeaseExpenseDetails" xlink:href="ameh-20191231.xsd#LeasesComponentsOfLeaseExpenseDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesFutureMinimumPaymentsUnderNonCancelableLeasesAfterAdoptionOf842Details" xlink:href="ameh-20191231.xsd#LeasesFutureMinimumPaymentsUnderNonCancelableLeasesAfterAdoptionOf842Details" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesFutureMinimumPaymentsUnderNonCancelableLeasesPriorToAdoptionOf842Details" xlink:href="ameh-20191231.xsd#LeasesFutureMinimumPaymentsUnderNonCancelableLeasesPriorToAdoptionOf842Details" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesOtherInformationRelatedToLeasesDetails" xlink:href="ameh-20191231.xsd#LeasesOtherInformationRelatedToLeasesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LeasesTables" xlink:href="ameh-20191231.xsd#LeasesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LoansReceivableAndLoansReceivableRelatedParties" xlink:href="ameh-20191231.xsd#LoansReceivableAndLoansReceivableRelatedParties" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/LoansReceivableAndLoansReceivableRelatedPartiesAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#LoansReceivableAndLoansReceivableRelatedPartiesAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MedicalLiabilities" xlink:href="ameh-20191231.xsd#MedicalLiabilities" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MedicalLiabilitiesScheduleOfMedicalLiabilitiesDetails" xlink:href="ameh-20191231.xsd#MedicalLiabilitiesScheduleOfMedicalLiabilitiesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MedicalLiabilitiesTables" xlink:href="ameh-20191231.xsd#MedicalLiabilitiesTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquity" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquity" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityApcDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityApcDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityDividendsAndTreasuryStockDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityDividendsAndTreasuryStockDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityEquityIncentivePlansDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityEquityIncentivePlansDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityScheduleOfStockOptionsActivityDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityScheduleOfStockOptionsActivityDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityShareholdersEquityDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityShareholdersEquityDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfRemainingUnrecognizedShareBasedCompensationOfStockOptionDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquitySummaryOfRemainingUnrecognizedShareBasedCompensationOfStockOptionDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfStockOptionActivityUnderBlackScholesOptionDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquitySummaryOfStockOptionActivityUnderBlackScholesOptionDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfWarrantsDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquitySummaryOfWarrantsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityTables" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityWarrantsDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityWarrantsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/MezzanineAndShareholdersEquityWarrantsNarrativeDetails" xlink:href="ameh-20191231.xsd#MezzanineAndShareholdersEquityWarrantsNarrativeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RelatedPartyTransactions" xlink:href="ameh-20191231.xsd#RelatedPartyTransactions" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RelatedPartyTransactionsAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#RelatedPartyTransactionsAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RelatedPartyTransactionsScheduleOfRelatedPartyTransactionsDetails" xlink:href="ameh-20191231.xsd#RelatedPartyTransactionsScheduleOfRelatedPartyTransactionsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RelatedPartyTransactionsTables" xlink:href="ameh-20191231.xsd#RelatedPartyTransactionsTables" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RevenueRecognition" xlink:href="ameh-20191231.xsd#RevenueRecognition" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/RevenueRecognitionAdditionalInformationDetails" xlink:href="ameh-20191231.xsd#RevenueRecognitionAdditionalInformationDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/VariableInterestEntitiesVies" xlink:href="ameh-20191231.xsd#VariableInterestEntitiesVies" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/VariableInterestEntitiesViesEliminatedUponConsolidationIncludedInAccompanyingConsolidatedBalanceSheetsDetails" xlink:href="ameh-20191231.xsd#VariableInterestEntitiesViesEliminatedUponConsolidationIncludedInAccompanyingConsolidatedBalanceSheetsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://www.apollomed.net/role/VariableInterestEntitiesViesTables" xlink:href="ameh-20191231.xsd#VariableInterestEntitiesViesTables" xlink:type="simple"/>

<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>

<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>

<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>

<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>

<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/AccountsPayableAndAccruedExpenses" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/AccountsPayableAndAccruedExpensesScheduleOfAccountsPayableAndAccruedExpensesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/AccountsPayableAndAccruedExpensesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="ameh-20191231.xsd#ameh_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:type="locator"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_CBBC8F9F48B1CD8567AAC4D993EA18F8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_srt_RangeAxis_CBBC8F9F48B1CD8567AAC4D993EA18F8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_CBBC8F9F48B1CD8567AAC4D993EA18F8" xlink:to="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_CBBC8F9F48B1CD8567AAC4D993EA18F8" xlink:to="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_19B62BE17E31A26E5F57C4D993EA592F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388" xlink:to="loc_srt_MinimumMember_19B62BE17E31A26E5F57C4D993EA592F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_0D80C7AC96ABFD29F09CC4D993EBA83B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_536D91311B66AB4A48E7C4D993EA0388" xlink:to="loc_srt_MaximumMember_0D80C7AC96ABFD29F09CC4D993EBA83B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_C7AD4F9A0CB472E9CD7DC4D993EB7A7C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_C7AD4F9A0CB472E9CD7DC4D993EB7A7C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_4937458EACE1CF85B390C4D993EBE5A0_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_C7AD4F9A0CB472E9CD7DC4D993EB7A7C" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_4937458EACE1CF85B390C4D993EBE5A0_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_C7AD4F9A0CB472E9CD7DC4D993EB7A7C" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_4937458EACE1CF85B390C4D993EBE5A0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicareLicenseMember" xlink:label="loc_ameh_MedicareLicenseMember_056545863A9EC46CF52AC4D993EB2B64" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_4937458EACE1CF85B390C4D993EBE5A0" xlink:to="loc_ameh_MedicareLicenseMember_056545863A9EC46CF52AC4D993EB2B64" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_2C26ACC54F9F60749479C4D993EC5893" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_2C26ACC54F9F60749479C4D993EC5893" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_3A107470265303C080B4C4D993EC91F2_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_2C26ACC54F9F60749479C4D993EC5893" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_3A107470265303C080B4C4D993EC91F2_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_2C26ACC54F9F60749479C4D993EC5893" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_3A107470265303C080B4C4D993EC91F2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PacificAmbulatorySurgeryCenterLlcMember" xlink:label="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_9834888D1B0A96D9A629C4D993EC6ACF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_3A107470265303C080B4C4D993EC91F2" xlink:to="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_9834888D1B0A96D9A629C4D993EC6ACF" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_F5EE41BB94732B18ED74C4D993EC8AAE" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_dei_LegalEntityAxis_F5EE41BB94732B18ED74C4D993EC8AAE" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3999CF96D504799C32C7C4D993ED987F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_F5EE41BB94732B18ED74C4D993EC8AAE" xlink:to="loc_dei_EntityDomain_3999CF96D504799C32C7C4D993ED987F_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3999CF96D504799C32C7C4D993ED987F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_F5EE41BB94732B18ED74C4D993EC8AAE" xlink:to="loc_dei_EntityDomain_3999CF96D504799C32C7C4D993ED987F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApaacoMember" xlink:label="loc_ameh_ApaacoMember_86050FFA9B783CEFCFEBC4D993ED4EFB" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3999CF96D504799C32C7C4D993ED987F" xlink:to="loc_ameh_ApaacoMember_86050FFA9B783CEFCFEBC4D993ED4EFB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_4203597CA97958B621F5C4D993ED6B0B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_srt_ProductOrServiceAxis_4203597CA97958B621F5C4D993ED6B0B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_2FB6EC84F5033BD79623C4D993ED1CF7_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_4203597CA97958B621F5C4D993ED6B0B" xlink:to="loc_srt_ProductsAndServicesDomain_2FB6EC84F5033BD79623C4D993ED1CF7_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_4203597CA97958B621F5C4D993ED6B0B" xlink:to="loc_srt_ProductsAndServicesDomain_2FB6EC84F5033BD79623C4D993ED1CF7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PerMemberPerMonthManagedCareContractMember" xlink:label="loc_ameh_PerMemberPerMonthManagedCareContractMember_216D20BBF4FDD35867D1C4D993EEBB79" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2FB6EC84F5033BD79623C4D993ED1CF7" xlink:to="loc_ameh_PerMemberPerMonthManagedCareContractMember_216D20BBF4FDD35867D1C4D993EEBB79" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ManagementServiceMember" xlink:label="loc_us-gaap_ManagementServiceMember_ABAD1CBB20138D55757AC4D993EE81B8" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2FB6EC84F5033BD79623C4D993ED1CF7" xlink:to="loc_us-gaap_ManagementServiceMember_ABAD1CBB20138D55757AC4D993EE81B8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7BDE9DA8E5979080353DC4D993EE94D1" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_srt_CounterpartyNameAxis_7BDE9DA8E5979080353DC4D993EE94D1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_289362950F5609EC6D69C4D993EE8409_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7BDE9DA8E5979080353DC4D993EE94D1" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_289362950F5609EC6D69C4D993EE8409_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7BDE9DA8E5979080353DC4D993EE94D1" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_289362950F5609EC6D69C4D993EE8409" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CMSMember" xlink:label="loc_ameh_CMSMember_59B49DED271B0777B034C4D993EFFD10" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_289362950F5609EC6D69C4D993EE8409" xlink:to="loc_ameh_CMSMember_59B49DED271B0777B034C4D993EFFD10" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_8924CB8B8D7F6898E0FCC4D993EF4C2F" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_8924CB8B8D7F6898E0FCC4D993EF4C2F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_9CBB1E49B2E1627446D8C4D993EF1A61_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8924CB8B8D7F6898E0FCC4D993EF4C2F" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_9CBB1E49B2E1627446D8C4D993EF1A61_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8924CB8B8D7F6898E0FCC4D993EF4C2F" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_9CBB1E49B2E1627446D8C4D993EF1A61" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountsPayableAndAccruedExpensesMember" xlink:label="loc_ameh_AccountsPayableAndAccruedExpensesMember_1E307289C79196299543C4D993EF78C3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_9CBB1E49B2E1627446D8C4D993EF1A61" xlink:to="loc_ameh_AccountsPayableAndAccruedExpensesMember_1E307289C79196299543C4D993EF78C3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OtherReceivablesMember" xlink:label="loc_ameh_OtherReceivablesMember_EF2973F75B8FD95E13DDC4D993F0D3B1" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_9CBB1E49B2E1627446D8C4D993EF1A61" xlink:to="loc_ameh_OtherReceivablesMember_EF2973F75B8FD95E13DDC4D993F0D3B1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1E4514EE847EFD7CB778C4D993F0B566" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesTable_33D77389BB871ECCAB78C4D993EA0100" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1E4514EE847EFD7CB778C4D993F0B566" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivableTypeDomain" xlink:label="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1E4514EE847EFD7CB778C4D993F0B566" xlink:to="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1E4514EE847EFD7CB778C4D993F0B566" xlink:to="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OtherReceivablesRelatedToIBNRMember" xlink:label="loc_ameh_OtherReceivablesRelatedToIBNRMember_94F2398502A3963A3031C4D993F03D83" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2" xlink:to="loc_ameh_OtherReceivablesRelatedToIBNRMember_94F2398502A3963A3031C4D993F03D83" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OtherReceivablesFinalSettlement2017PerformanceYearMember" xlink:label="loc_ameh_OtherReceivablesFinalSettlement2017PerformanceYearMember_D789DEB4CB137FAB61F6C4D993F06D8F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2" xlink:to="loc_ameh_OtherReceivablesFinalSettlement2017PerformanceYearMember_D789DEB4CB137FAB61F6C4D993F06D8F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OtherReceivablesRiskEarnings2018PerformanceYearMember" xlink:label="loc_ameh_OtherReceivablesRiskEarnings2018PerformanceYearMember_04D316E364BFB5009029C4D993F17374" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_19F0535E84B9A013342AC4D993F045C2" xlink:to="loc_ameh_OtherReceivablesRiskEarnings2018PerformanceYearMember_04D316E364BFB5009029C4D993F17374" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfOperatingSegments" xlink:label="loc_us-gaap_NumberOfOperatingSegments_56E735C6ACD3B80FB2DDC4D993F18B2E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_NumberOfOperatingSegments_56E735C6ACD3B80FB2DDC4D993F18B2E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_18EC911255052AC8B54CC4D993F1A8FD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_NumberOfReportableSegments_18EC911255052AC8B54CC4D993F1A8FD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashUninsuredAmount" xlink:label="loc_us-gaap_CashUninsuredAmount_81B6E4BB09CE5B2BD34BC4D993F18C8F" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_CashUninsuredAmount_81B6E4BB09CE5B2BD34BC4D993F18C8F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_BCD07521DABFB5EAA282C4D993F24AB6" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_BCD07521DABFB5EAA282C4D993F24AB6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCash" xlink:label="loc_us-gaap_RestrictedCash_42CAFA6CB95D27B0147EC4D993F21151" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_RestrictedCash_42CAFA6CB95D27B0147EC4D993F21151" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_F618ADC9AF59EA8D5F9AC4D993F2DA15" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_F618ADC9AF59EA8D5F9AC4D993F2DA15" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_BF8651C336350F2C0F44C4D993F20CF2" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_BF8651C336350F2C0F44C4D993F20CF2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_ACD6CB036B9A7BB0CA2BC4D993F298F3" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_ACD6CB036B9A7BB0CA2BC4D993F298F3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_C3409841D8897004D74BC4D993F2B624" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_C3409841D8897004D74BC4D993F2B624" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfReportingUnits" xlink:label="loc_us-gaap_NumberOfReportingUnits_CC62DCCCACBDD69C7F5EC4D993F37A41" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_NumberOfReportingUnits_CC62DCCCACBDD69C7F5EC4D993F37A41" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_0AFCA4960B4EE22ECC6BC4D993F37410" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_0AFCA4960B4EE22ECC6BC4D993F37410" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_0838E776A5ADAAC40958C4D993F3955D" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_0838E776A5ADAAC40958C4D993F3955D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment" xlink:label="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_956880C64BE3B61D62CFC4D993F36015" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_956880C64BE3B61D62CFC4D993F36015" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EstimatedRevenuePercentage" xlink:label="loc_ameh_EstimatedRevenuePercentage_C9DD95362AF86316015CC4D993F3865F" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_EstimatedRevenuePercentage_C9DD95362AF86316015CC4D993F3865F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BillingInExcessOfCosts" xlink:label="loc_ameh_BillingInExcessOfCosts_8B5EF53703648D52FF00C4D993F3D5B6" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_BillingInExcessOfCosts_8B5EF53703648D52FF00C4D993F3D5B6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuePerformanceObligationDescriptionOfTiming" xlink:label="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_8550761948089EC1550AC4DA9C3D057E" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_8550761948089EC1550AC4DA9C3D057E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriodOfPaymentUponFinalizationOfSettlementReport" xlink:label="loc_ameh_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriodOfPaymentUponFinalizationOfSettlementReport_796079642FF0A6162CFCC4D993F4C1ED" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriodOfPaymentUponFinalizationOfSettlementReport_796079642FF0A6162CFCC4D993F4C1ED" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_RiskPoolSettlement" xlink:label="loc_ameh_RiskPoolSettlement_5641C4793E0E0BD3FE2CC4D993F4E947" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_RiskPoolSettlement_5641C4793E0E0BD3FE2CC4D993F4E947" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentOfRevenue" xlink:label="loc_ameh_PaymentOfRevenue_7403F2AC96077C4B6AF5C4D993F42276" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_PaymentOfRevenue_7403F2AC96077C4B6AF5C4D993F42276" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentOfRevenueReduce" xlink:label="loc_ameh_PaymentOfRevenueReduce_4988770E167A928D5F9CC4D993F43182" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_PaymentOfRevenueReduce_4988770E167A928D5F9CC4D993F43182" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AllInclusivePopulationBasedPaymentsToBeReceived" xlink:label="loc_ameh_AllInclusivePopulationBasedPaymentsToBeReceived_054CE39042F24D63C28CC4D993F4E123" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_ameh_AllInclusivePopulationBasedPaymentsToBeReceived_054CE39042F24D63C28CC4D993F4E123" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_64D85B125FC6D7DD5767C4D993F585B7" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_64D85B125FC6D7DD5767C4D993F585B7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReinsuranceRecoverables" xlink:label="loc_us-gaap_ReinsuranceRecoverables_BD07E3787269909C62F2C4D993F5F086" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_ReinsuranceRecoverables_BD07E3787269909C62F2C4D993F5F086" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredCreditsAndOtherLiabilitiesCurrent" xlink:label="loc_us-gaap_DeferredCreditsAndOtherLiabilitiesCurrent_13233DB9B15C74DA34C7C4D993F59535" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_DeferredCreditsAndOtherLiabilitiesCurrent_13233DB9B15C74DA34C7C4D993F59535" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="loc_us-gaap_VariableInterestEntityOwnershipPercentage_A5F59C3FBB4FA984165AC4D993F519CF" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_VariableInterestEntityOwnershipPercentage_A5F59C3FBB4FA984165AC4D993F519CF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_D92B1554D1A21E106C10C4D993F5CB07" xlink:type="locator"/>

<link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_D92B1554D1A21E106C10C4D993F5CB07" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaap_OperatingLeaseLiability_9977588CF9830E1461C8C4D993F58F1B" xlink:type="locator"/>

<link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_SummaryOfSignificantAccountingPoliciesLineItems_FC1D07FEAE318FC7DD55C4D993F1EF57" xlink:to="loc_us-gaap_OperatingLeaseLiability_9977588CF9830E1461C8C4D993F58F1B" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationPerformanceObligationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_D32CC19ED9AB1D0FEF96C4E3A1B2BF49" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_7D4BA7C59C664DACB985C4E3A1B10DDB" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_D32CC19ED9AB1D0FEF96C4E3A1B2BF49" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_7D4BA7C59C664DACB985C4E3A1B10DDB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_D94F471FD0492D349524C4E3A211C964" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_7D4BA7C59C664DACB985C4E3A1B10DDB" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_D94F471FD0492D349524C4E3A211C964" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_12D15D9C797ABB530846C4E3A1E5B53E" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_7D4BA7C59C664DACB985C4E3A1B10DDB" xlink:to="loc_srt_ProductOrServiceAxis_12D15D9C797ABB530846C4E3A1E5B53E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_D833B69B7AAC223659CCC4E3A1E95357_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_12D15D9C797ABB530846C4E3A1E5B53E" xlink:to="loc_srt_ProductsAndServicesDomain_D833B69B7AAC223659CCC4E3A1E95357_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_D833B69B7AAC223659CCC4E3A1E95357" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_12D15D9C797ABB530846C4E3A1E5B53E" xlink:to="loc_srt_ProductsAndServicesDomain_D833B69B7AAC223659CCC4E3A1E95357" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NextGenerationACOModelParticipationAgreementMember" xlink:label="loc_ameh_NextGenerationACOModelParticipationAgreementMember_8E85C162B1C4CA696574C4E3A228234C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_D833B69B7AAC223659CCC4E3A1E95357" xlink:to="loc_ameh_NextGenerationACOModelParticipationAgreementMember_8E85C162B1C4CA696574C4E3A228234C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_502CFF7DB2BCBCCB08F8C4E3A1CD08F0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_D32CC19ED9AB1D0FEF96C4E3A1B2BF49" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_502CFF7DB2BCBCCB08F8C4E3A1CD08F0" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesCarryingAmountsAndFairValuesOfCompanysFinancialInstrumentsDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1A06AD62915DF606A366C1379674A44A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1A06AD62915DF606A366C1379674A44A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A4B9621F16451E89B689C13796742444" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1A06AD62915DF606A366C1379674A44A" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A4B9621F16451E89B689C13796742444" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A4B9621F16451E89B689C13796742444" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_A4B9621F16451E89B689C13796742444" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_7D5A8D6F8BBD7536EE91C13796752FEC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_7D5A8D6F8BBD7536EE91C13796752FEC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_6555374774B9B1B90D24C13796754D81" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_6555374774B9B1B90D24C13796754D81" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_2249BC4B6A2229BEA809C1379675FC3B" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F02E7C47F62426CB2FFBC13796757C5E" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_2249BC4B6A2229BEA809C1379675FC3B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1E92EE1C1F647081CDC9C1379676188E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1E92EE1C1F647081CDC9C1379676188E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_96FAC5C6B4FDAEBE138BC13796767C37" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_96FAC5C6B4FDAEBE138BC13796767C37" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_D7A6DD3466F948B891F9C13796769AFB" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_D7A6DD3466F948B891F9C13796769AFB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_32016EA5E08CDA823A2AC137967658D1" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_17447FDD896D1DAB374CC13796764EB6" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_32016EA5E08CDA823A2AC137967658D1" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesContributionsToRevenueAndReceivablesByPayorDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_7C1C4F073098B9611EF5C137967E6D1A" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_F0B92D82277A4B1DB18CC137967AAE7A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_7C1C4F073098B9611EF5C137967E6D1A" xlink:to="loc_us-gaap_ConcentrationRiskTable_F0B92D82277A4B1DB18CC137967AAE7A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8185C55BD7BDF5BA690BC137967B9520" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_F0B92D82277A4B1DB18CC137967AAE7A" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8185C55BD7BDF5BA690BC137967B9520" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_746B464577DDC08B823CC137967B8822_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8185C55BD7BDF5BA690BC137967B9520" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_746B464577DDC08B823CC137967B8822_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8185C55BD7BDF5BA690BC137967B9520" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_746B464577DDC08B823CC137967B8822" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_0AB784D31ED7CDC5070AC137967BEB79" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_746B464577DDC08B823CC137967B8822" xlink:to="loc_us-gaap_SalesRevenueNetMember_0AB784D31ED7CDC5070AC137967BEB79" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_BFA2EE6CF3712D78B38AC137967CAD52" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_746B464577DDC08B823CC137967B8822" xlink:to="loc_us-gaap_AccountsReceivableMember_BFA2EE6CF3712D78B38AC137967CAD52" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_6ED951737B0AE4DB331AC137967CAD85" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_F0B92D82277A4B1DB18CC137967AAE7A" xlink:to="loc_srt_MajorCustomersAxis_6ED951737B0AE4DB331AC137967CAD85" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_6ED951737B0AE4DB331AC137967CAD85" xlink:to="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_6ED951737B0AE4DB331AC137967CAD85" xlink:to="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorAMember" xlink:label="loc_ameh_PayorAMember_415AD6E49CDD2C88AC1AC137967CA07C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorAMember_415AD6E49CDD2C88AC1AC137967CA07C" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorBMember" xlink:label="loc_ameh_PayorBMember_A6F6E2179C437E3E3DDCC137967DCA21" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorBMember_A6F6E2179C437E3E3DDCC137967DCA21" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorCMember" xlink:label="loc_ameh_PayorCMember_F750490163BDE6404155C137967D6FDE" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorCMember_F750490163BDE6404155C137967D6FDE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorDMember" xlink:label="loc_ameh_PayorDMember_D690148B71FAEC42908CC137967D3E63" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorDMember_D690148B71FAEC42908CC137967D3E63" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorEMember" xlink:label="loc_ameh_PayorEMember_D02EB565D4E5B73BE2B2C137967D6FEB" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorEMember_D02EB565D4E5B73BE2B2C137967D6FEB" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorFMember" xlink:label="loc_ameh_PayorFMember_1F130BCCA32E65850ACDC137967DEEC2" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorFMember_1F130BCCA32E65850ACDC137967DEEC2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorGMember" xlink:label="loc_ameh_PayorGMember_8EFE38C22B51B745DFCFC137967DF9BB" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorGMember_8EFE38C22B51B745DFCFC137967DF9BB" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PayorHMember" xlink:label="loc_ameh_PayorHMember_8E586F15B388BD7B0542C137967EE71F" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_BA96623081A9D2AD1E31C137967C1A15" xlink:to="loc_ameh_PayorHMember_8E586F15B388BD7B0542C137967EE71F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_D410A896EF5FD70DD1A6C137967E8D34" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_7C1C4F073098B9611EF5C137967E6D1A" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_D410A896EF5FD70DD1A6C137967E8D34" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDisaggregationOfRevenueByPayorTypeDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_4FA85968BB2FA63D535BC12C7F52AD43" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_A6968C32C8732A607072C12C7F51C89A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4FA85968BB2FA63D535BC12C7F52AD43" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_A6968C32C8732A607072C12C7F51C89A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_5E4938E4D5292C1B07DBC12C7F5139AF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A6968C32C8732A607072C12C7F51C89A" xlink:to="loc_srt_MajorCustomersAxis_5E4938E4D5292C1B07DBC12C7F5139AF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_5E4938E4D5292C1B07DBC12C7F5139AF" xlink:to="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_5E4938E4D5292C1B07DBC12C7F5139AF" xlink:to="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CommercialMember" xlink:label="loc_ameh_CommercialMember_E58F5592604F440950F7C12C7F511FB6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:to="loc_ameh_CommercialMember_E58F5592604F440950F7C12C7F511FB6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicareMember" xlink:label="loc_ameh_MedicareMember_16287B21B3CF2555DA9DC12C7F523BC6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:to="loc_ameh_MedicareMember_16287B21B3CF2555DA9DC12C7F523BC6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicaidMember" xlink:label="loc_ameh_MedicaidMember_9F6A8C8D6717E0FCE158C12C7F529011" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:to="loc_ameh_MedicaidMember_9F6A8C8D6717E0FCE158C12C7F529011" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OtherThirdPartiesMember" xlink:label="loc_ameh_OtherThirdPartiesMember_365C9764654C8BBE4062C12C7F527DA1" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_98BC35B2A6FA489283F2C12C7F51CE4A" xlink:to="loc_ameh_OtherThirdPartiesMember_365C9764654C8BBE4062C12C7F527DA1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_82934EB2132A16FF2C7FC12C7F523C74" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4FA85968BB2FA63D535BC12C7F52AD43" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_82934EB2132A16FF2C7FC12C7F523C74" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwill" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_0EBABC1B3E563EF7C3A2E47B93DC8030" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_0EBABC1B3E563EF7C3A2E47B93DC8030" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0EBABC1B3E563EF7C3A2E47B93DC8030" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0EBABC1B3E563EF7C3A2E47B93DC8030" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApolloMedicalHoldingsIncMember" xlink:label="loc_ameh_ApolloMedicalHoldingsIncMember_480006336B661085D616E47B93DDEE49" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9" xlink:to="loc_ameh_ApolloMedicalHoldingsIncMember_480006336B661085D616E47B93DDEE49" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_5FB6A0D68970B7D06086E47B93DD37AF" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_5FB6A0D68970B7D06086E47B93DD37AF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_1F8DE161F07E474C789EE47B93DD4DCE" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9" xlink:to="loc_ameh_AccountableHealthCareIPAMember_1F8DE161F07E474C789EE47B93DD4DCE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AmgIncMember" xlink:label="loc_ameh_AmgIncMember_F090260125D4A06087ECE47B93DD1857" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_656D9F10CE5531392066E47B93DDE1E9" xlink:to="loc_ameh_AmgIncMember_F090260125D4A06087ECE47B93DD1857" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_7E592FAFE02E290F720DE47B93DE83B3" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_dei_LegalEntityAxis_7E592FAFE02E290F720DE47B93DE83B3" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_7E592FAFE02E290F720DE47B93DE83B3" xlink:to="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_7E592FAFE02E290F720DE47B93DE83B3" xlink:to="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_EA4B192ED959DE7127BDE47B93DE76B8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_EA4B192ED959DE7127BDE47B93DE76B8" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApolloMedicalHoldingsIncMember" xlink:label="loc_ameh_ApolloMedicalHoldingsIncMember_77408EA20104EB56D851E47B93DE040D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_ApolloMedicalHoldingsIncMember_77408EA20104EB56D851E47B93DE040D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AllianceApexLlcMember" xlink:label="loc_ameh_AllianceApexLlcMember_EB688B0F9290011991C5E47B93DF141A" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_AllianceApexLlcMember_EB688B0F9290011991C5E47B93DF141A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AllianceApexLLCManagerMember" xlink:label="loc_ameh_AllianceApexLLCManagerMember_BD0D5BB25EE0BEE95F55E48159BC6F98" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_AllianceApexLLCManagerMember_BD0D5BB25EE0BEE95F55E48159BC6F98" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APCAndAPCLSMAMember" xlink:label="loc_ameh_APCAndAPCLSMAMember_AE2BD5BB6457AABBA367E47B93DF5DCE" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_APCAndAPCLSMAMember_AE2BD5BB6457AABBA367E47B93DF5DCE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_F5CAC1F08A36A67B58A7E47B93DF77DB" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4EE1B6869FA19FD98076E47B93DE8D55" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_F5CAC1F08A36A67B58A7E47B93DF77DB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2C182B7D1538522662E5E48309466FB1" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2C182B7D1538522662E5E48309466FB1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_06E4216DD4647B899FADE48309488F93_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2C182B7D1538522662E5E48309466FB1" xlink:to="loc_us-gaap_RelatedPartyDomain_06E4216DD4647B899FADE48309488F93_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2C182B7D1538522662E5E48309466FB1" xlink:to="loc_us-gaap_RelatedPartyDomain_06E4216DD4647B899FADE48309488F93" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_ECD7CEDF79F579058ED0E483416C5EB0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_06E4216DD4647B899FADE48309488F93" xlink:to="loc_us-gaap_DirectorMember_ECD7CEDF79F579058ED0E483416C5EB0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_BDAA62014A22E3276B92E48200755CFF" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_BDAA62014A22E3276B92E48200755CFF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_FE7C826C6E38D694C514E48200795FEA_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_BDAA62014A22E3276B92E48200755CFF" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_FE7C826C6E38D694C514E48200795FEA_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_FE7C826C6E38D694C514E48200795FEA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_BDAA62014A22E3276B92E48200755CFF" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_FE7C826C6E38D694C514E48200795FEA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AllianceApexLlcMember" xlink:label="loc_ameh_AllianceApexLlcMember_9FEDEE0EC032042F3163E482586D8412" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_FE7C826C6E38D694C514E48200795FEA" xlink:to="loc_ameh_AllianceApexLlcMember_9FEDEE0EC032042F3163E482586D8412" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_C2531DEEE9C9818B5970E47B93DFEEB8" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_C2531DEEE9C9818B5970E47B93DFEEB8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_4A3A8FBEF059EF0690E6E47B93DFC856_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_C2531DEEE9C9818B5970E47B93DFEEB8" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_4A3A8FBEF059EF0690E6E47B93DFC856_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_C2531DEEE9C9818B5970E47B93DFEEB8" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_4A3A8FBEF059EF0690E6E47B93DFC856" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantOneMember" xlink:label="loc_ameh_WarrantOneMember_EB74B19B895B56D46464E47B93DF6C22" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_4A3A8FBEF059EF0690E6E47B93DFC856" xlink:to="loc_ameh_WarrantOneMember_EB74B19B895B56D46464E47B93DF6C22" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantTwoMember" xlink:label="loc_ameh_WarrantTwoMember_20E3D8E4BCE871B73692E47B93E0AC1F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_4A3A8FBEF059EF0690E6E47B93DFC856" xlink:to="loc_ameh_WarrantTwoMember_20E3D8E4BCE871B73692E47B93E0AC1F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_CD8D8AFEC1B44149B368E47B93E0DED3" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_DebtInstrumentAxis_CD8D8AFEC1B44149B368E47B93E0DED3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_FE7F3388E5A9C606A2C2E47B93E03FDC_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_CD8D8AFEC1B44149B368E47B93E0DED3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_FE7F3388E5A9C606A2C2E47B93E03FDC_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_CD8D8AFEC1B44149B368E47B93E0DED3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_FE7F3388E5A9C606A2C2E47B93E03FDC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ConvertiblePromissoryNoteMember" xlink:label="loc_ameh_ConvertiblePromissoryNoteMember_30CB1C48A6EE56D1F953E47B93E06731" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_FE7F3388E5A9C606A2C2E47B93E03FDC" xlink:to="loc_ameh_ConvertiblePromissoryNoteMember_30CB1C48A6EE56D1F953E47B93E06731" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_05470B1778AB5F12CF51E47B93E08C2F" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_srt_CounterpartyNameAxis_05470B1778AB5F12CF51E47B93E08C2F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_DFCC5472D66C91180075E47B93E18076_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_05470B1778AB5F12CF51E47B93E08C2F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_DFCC5472D66C91180075E47B93E18076_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_DFCC5472D66C91180075E47B93E18076" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_05470B1778AB5F12CF51E47B93E08C2F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_DFCC5472D66C91180075E47B93E18076" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.JayMember" xlink:label="loc_ameh_Dr.JayMember_C6B0EAAC7C53CE398A58E47B93E108AD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_DFCC5472D66C91180075E47B93E18076" xlink:to="loc_ameh_Dr.JayMember_C6B0EAAC7C53CE398A58E47B93E108AD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="loc_srt_ConsolidatedEntitiesAxis_EF92D66CBACABF53B77AE47B93E19FD6" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_srt_ConsolidatedEntitiesAxis_EF92D66CBACABF53B77AE47B93E19FD6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="loc_srt_ConsolidatedEntitiesDomain_D0291DD8B0B886D0FBEFE47B93E10B9A_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_EF92D66CBACABF53B77AE47B93E19FD6" xlink:to="loc_srt_ConsolidatedEntitiesDomain_D0291DD8B0B886D0FBEFE47B93E10B9A_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_EF92D66CBACABF53B77AE47B93E19FD6" xlink:to="loc_srt_ConsolidatedEntitiesDomain_D0291DD8B0B886D0FBEFE47B93E10B9A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApaAcoIncMember" xlink:label="loc_ameh_ApaAcoIncMember_633C317AD0E3CC7649CFE47B93E295D2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_D0291DD8B0B886D0FBEFE47B93E10B9A" xlink:to="loc_ameh_ApaAcoIncMember_633C317AD0E3CC7649CFE47B93E295D2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_AAF67C38437B911CE9DAE47B93E2534B" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_AAF67C38437B911CE9DAE47B93E2534B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_9DAE4A903204EE691DAAE47B93E21A60_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_AAF67C38437B911CE9DAE47B93E2534B" xlink:to="loc_us-gaap_EquityComponentDomain_9DAE4A903204EE691DAAE47B93E21A60_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_AAF67C38437B911CE9DAE47B93E2534B" xlink:to="loc_us-gaap_EquityComponentDomain_9DAE4A903204EE691DAAE47B93E21A60" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_53B13ACE081CACCFFBB9E47B93E22C6F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_9DAE4A903204EE691DAAE47B93E21A60" xlink:to="loc_us-gaap_NoncontrollingInterestMember_53B13ACE081CACCFFBB9E47B93E22C6F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_0DF157A7E23FD7FC5736E47B93E37DFE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_9DAE4A903204EE691DAAE47B93E21A60" xlink:to="loc_us-gaap_PreferredStockMember_0DF157A7E23FD7FC5736E47B93E37DFE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_2CD33402486A8D624268E47B93E3CE9B" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_2CD33402486A8D624268E47B93E3CE9B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_65C005CF5A9343A80403E47B93E30F39_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_2CD33402486A8D624268E47B93E3CE9B" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_65C005CF5A9343A80403E47B93E30F39_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_2CD33402486A8D624268E47B93E3CE9B" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_65C005CF5A9343A80403E47B93E30F39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_8EA59B51543707B8D256E47B93E30E91" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_65C005CF5A9343A80403E47B93E30F39" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_8EA59B51543707B8D256E47B93E30E91" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_624D5586D83A47975E52E47B93E45B73" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_65C005CF5A9343A80403E47B93E30F39" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_624D5586D83A47975E52E47B93E45B73" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_D2EC0B785C218ACC1C37E47B93E4B061" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_StatementClassOfStockAxis_D2EC0B785C218ACC1C37E47B93E4B061" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_42D70018A3693DAFF0B0E47B93E4E43B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_D2EC0B785C218ACC1C37E47B93E4B061" xlink:to="loc_us-gaap_ClassOfStockDomain_42D70018A3693DAFF0B0E47B93E4E43B_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_D2EC0B785C218ACC1C37E47B93E4B061" xlink:to="loc_us-gaap_ClassOfStockDomain_42D70018A3693DAFF0B0E47B93E4E43B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassBMember" xlink:label="loc_us-gaap_CommonClassBMember_B1E644A92DB0F7AFB008E47B93E4AB91" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_42D70018A3693DAFF0B0E47B93E4E43B" xlink:to="loc_us-gaap_CommonClassBMember_B1E644A92DB0F7AFB008E47B93E4AB91" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_6E54FC6E0EAA36FA9DEEE47B93E48D70" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_E5021E35073BAAC01A35E47B93DC35EE" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_6E54FC6E0EAA36FA9DEEE47B93E48D70" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_BF9EF0CD5059B43DE15CE47B93E58BC5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_6E54FC6E0EAA36FA9DEEE47B93E48D70" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_BF9EF0CD5059B43DE15CE47B93E58BC5_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_6E54FC6E0EAA36FA9DEEE47B93E48D70" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_BF9EF0CD5059B43DE15CE47B93E58BC5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_27674F1F798B23EDCD17E47B93E5DDEC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_BF9EF0CD5059B43DE15CE47B93E58BC5" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_27674F1F798B23EDCD17E47B93E5DDEC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_AD59D196E75D42BB96DFE47B93E5C2D5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_AD59D196E75D42BB96DFE47B93E5C2D5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NoncontrollingInterestIncreaseFromBusinessCombination" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromBusinessCombination_6AC73D1C8D215838EEB4E47B93E6821D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromBusinessCombination_6AC73D1C8D215838EEB4E47B93E6821D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationStepAcquisitionEquityInterestInAcquireeNumberOfShare" xlink:label="loc_ameh_BusinessCombinationStepAcquisitionEquityInterestInAcquireeNumberOfShare_34C698A1F51D53CC07E3E47B93E63034" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_BusinessCombinationStepAcquisitionEquityInterestInAcquireeNumberOfShare_34C698A1F51D53CC07E3E47B93E63034" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_40A2D96A926660C15776E47B93E6D174" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_40A2D96A926660C15776E47B93E6D174" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_13D1AE321BFC506FA618E47B93E6EF7B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_13D1AE321BFC506FA618E47B93E6EF7B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnification" xlink:label="loc_ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnification_4DE44A57AC8A2FEF282AE47B93E63C40" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnification_4DE44A57AC8A2FEF282AE47B93E63C40" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnificationHoldingPeriodAfterClosingOfMerger" xlink:label="loc_ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnificationHoldingPeriodAfterClosingOfMerger_7698E180863E5BCEF990E47B93E6FC87" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_BusinessAcquisitionPercentageOfVotingInterestsAcquiredHeldBackToSecureIndemnificationHoldingPeriodAfterClosingOfMerger_7698E180863E5BCEF990E47B93E6FC87" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_574EBC5B4B2530D50144E47B93E72B6F" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_574EBC5B4B2530D50144E47B93E72B6F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_68941D08127BAED60716E47B93E73D2D" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_68941D08127BAED60716E47B93E73D2D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_A6DBA5009C6730B97C3EE47B93E742A7" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_A6DBA5009C6730B97C3EE47B93E742A7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_526F19664356784AB5C1E47B93E7BEFC" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_526F19664356784AB5C1E47B93E7BEFC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1" xlink:label="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_5C2863836190DCB2FA96E47B93E759CF" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_5C2863836190DCB2FA96E47B93E759CF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FairValueAssumptionExpectedTerm" xlink:label="loc_ameh_FairValueAssumptionExpectedTerm_E3FE4616AA0DBB7D8CB0E47B93E74378" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_FairValueAssumptionExpectedTerm_E3FE4616AA0DBB7D8CB0E47B93E74378" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FairValueAssumptionsExpectedVolatilityRates" xlink:label="loc_ameh_FairValueAssumptionsExpectedVolatilityRates_8952B811422C3AA20AACE47B93E7BE6D" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_FairValueAssumptionsExpectedVolatilityRates_8952B811422C3AA20AACE47B93E7BE6D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FairValueAssumptionsRiskFreeInterestRates" xlink:label="loc_ameh_FairValueAssumptionsRiskFreeInterestRates_59E44882D29661EEEF96E47B93E843AD" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_FairValueAssumptionsRiskFreeInterestRates_59E44882D29661EEEF96E47B93E843AD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_F9F5F7CCB07C977D346FE47B93E88D0E" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_F9F5F7CCB07C977D346FE47B93E88D0E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillPurchaseAccountingAdjustments" xlink:label="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_97087FAFDD523FFDF463E47B93E864FE" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_97087FAFDD523FFDF463E47B93E864FE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions" xlink:label="loc_ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions_C4FB36A7B0C677108A5CE47B93E87C20" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions_C4FB36A7B0C677108A5CE47B93E87C20" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillSubsequentRecognitionOfDeferredTaxAsset" xlink:label="loc_us-gaap_GoodwillSubsequentRecognitionOfDeferredTaxAsset_54ED6DA17C1441169EECE47B93E89341" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_GoodwillSubsequentRecognitionOfDeferredTaxAsset_54ED6DA17C1441169EECE47B93E89341" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_GoodwillDecreaseMergerTransactionCosts" xlink:label="loc_ameh_GoodwillDecreaseMergerTransactionCosts_C80B30D345878B8935BEE47B93E86788" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_ameh_GoodwillDecreaseMergerTransactionCosts_C80B30D345878B8935BEE47B93E86788" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillPeriodIncreaseDecrease" xlink:label="loc_us-gaap_GoodwillPeriodIncreaseDecrease_D7C96F3BACF44A56EF10E47B93E9C69E" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_GoodwillPeriodIncreaseDecrease_D7C96F3BACF44A56EF10E47B93E9C69E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_0662CD160EC55C3B1237E47B93E956AA" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_0662CD160EC55C3B1237E47B93E956AA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_79AA7C8EF765779F496AE47B93E97EE5" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_79AA7C8EF765779F496AE47B93E97EE5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_27DB34185FF4B620B058E47B93E9F2D0" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_27DB34185FF4B620B058E47B93E9F2D0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EscrowDeposit" xlink:label="loc_us-gaap_EscrowDeposit_5F1DD803855809608A69E47B93E92808" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_EscrowDeposit_5F1DD803855809608A69E47B93E92808" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_B0F506A57A56A41B4D1CE47B93E919CA" xlink:type="locator"/>

<link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_B0F506A57A56A41B4D1CE47B93E919CA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_926BD1E0BAD76143B5B4E47B93EA94FC" xlink:type="locator"/>

<link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_926BD1E0BAD76143B5B4E47B93EA94FC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_05101DA9CECBEBF455C9E47B93EA726D" xlink:type="locator"/>

<link:definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_05101DA9CECBEBF455C9E47B93EA726D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfBusinessesAcquired" xlink:label="loc_us-gaap_NumberOfBusinessesAcquired_7E9AACCF5E310C1750E3E47B93EA43AB" xlink:type="locator"/>

<link:definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_NumberOfBusinessesAcquired_7E9AACCF5E310C1750E3E47B93EA43AB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_07CC29712FD9CD756463E47B93EAAF83" xlink:type="locator"/>

<link:definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_07CC29712FD9CD756463E47B93EAAF83" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_5DCC556DA08136A981FAE47B93EA67FF" xlink:type="locator"/>

<link:definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5D3076AD0894F5DA687CE47B93E58AF5" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_5DCC556DA08136A981FAE47B93EA67FF" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillAssumptionOfIdentifiableAssetsAcquiredAndLiabilitiesDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4FB1B79083890CFC3458CC83B60C5BDD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4FB1B79083890CFC3458CC83B60C5BDD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_304A740FD62EFDC381E3CC83B60C9117" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4FB1B79083890CFC3458CC83B60C5BDD" xlink:to="loc_dei_LegalEntityAxis_304A740FD62EFDC381E3CC83B60C9117" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_BC920D8DF235BC1C0D25CC83B60CDFF9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_304A740FD62EFDC381E3CC83B60C9117" xlink:to="loc_dei_EntityDomain_BC920D8DF235BC1C0D25CC83B60CDFF9_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_BC920D8DF235BC1C0D25CC83B60CDFF9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_304A740FD62EFDC381E3CC83B60C9117" xlink:to="loc_dei_EntityDomain_BC920D8DF235BC1C0D25CC83B60CDFF9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APCAndAPCLSMAMember" xlink:label="loc_ameh_APCAndAPCLSMAMember_DD0951A861B730D87291CC83B60DD12A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_BC920D8DF235BC1C0D25CC83B60CDFF9" xlink:to="loc_ameh_APCAndAPCLSMAMember_DD0951A861B730D87291CC83B60DD12A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_EF6D7B921C0C36DE94F8CC83B60D666F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4FB1B79083890CFC3458CC83B60C5BDD" xlink:to="loc_srt_CounterpartyNameAxis_EF6D7B921C0C36DE94F8CC83B60D666F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7C638F3E7E61D63FFA39CC83B60DA4AF_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_EF6D7B921C0C36DE94F8CC83B60D666F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7C638F3E7E61D63FFA39CC83B60DA4AF_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7C638F3E7E61D63FFA39CC83B60DA4AF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_EF6D7B921C0C36DE94F8CC83B60D666F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7C638F3E7E61D63FFA39CC83B60DA4AF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.JayMember" xlink:label="loc_ameh_Dr.JayMember_9752D0D1AC85CBC99031CC83B60EE230" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7C638F3E7E61D63FFA39CC83B60DA4AF" xlink:to="loc_ameh_Dr.JayMember_9752D0D1AC85CBC99031CC83B60EE230" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_7BDF55E6249C6C5A6A6ECC83B60EFC21" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_4FB1B79083890CFC3458CC83B60C5BDD" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_7BDF55E6249C6C5A6A6ECC83B60EFC21" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7BDF55E6249C6C5A6A6ECC83B60EFC21" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7BDF55E6249C6C5A6A6ECC83B60EFC21" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_0504E5850E8AE428129ECC83B60E56A3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_0504E5850E8AE428129ECC83B60E56A3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_9C30CB168E19CD816504CC83B60F2DA1" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37CF8D61835A37BBA5E9CC83B60E2D63" xlink:to="loc_ameh_AccountableHealthCareIPAMember_9C30CB168E19CD816504CC83B60F2DA1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_40D46CD9BBC15B2815D2CC83B60F5481" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_40D46CD9BBC15B2815D2CC83B60F5481" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_FF0901E79774C95EE276CC83B60F2861" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_FF0901E79774C95EE276CC83B60F2861" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_6B78CA1779C55986EBEDCC83B6107B61" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_6B78CA1779C55986EBEDCC83B6107B61" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_D1D6E3BE335F31A74EE5CC83B61017F3" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_D1D6E3BE335F31A74EE5CC83B61017F3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_017648F9532AF85362A4CC83B61029EF" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_017648F9532AF85362A4CC83B61029EF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsRestrictedCash" xlink:label="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsRestrictedCash_810327192610E94E34E6CC83B610B410" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsRestrictedCash_810327192610E94E34E6CC83B610B410" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_72D6A649700706134601CC83B610488D" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_72D6A649700706134601CC83B610488D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_8D005D3095181D088B63CC83B611A0DA" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_8D005D3095181D088B63CC83B611A0DA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_95C5A1ABFA6C54237971CC83B611603E" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_95C5A1ABFA6C54237971CC83B611603E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_6A34EA19B753574F16E8CC83B611EBE8" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_FF2CB14487AB8FB148F4CC83B60F3B66" xlink:to="loc_us-gaap_Goodwill_6A34EA19B753574F16E8CC83B611EBE8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_1324211CBAF7EF3F67A9CC83B611D382" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_1324211CBAF7EF3F67A9CC83B611D382" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_0C6F73EFCA1111125B6DCC83B6117E57" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_0C6F73EFCA1111125B6DCC83B6117E57" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedMedicalLiabilities" xlink:label="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedMedicalLiabilities_E0E47B10321D1D738814CC83B6125D21" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedMedicalLiabilities_E0E47B10321D1D738814CC83B6125D21" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities_D2E36CD0BC45ACFED3E3CC83B612EC62" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities_D2E36CD0BC45ACFED3E3CC83B612EC62" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLineOfCredit" xlink:label="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLineOfCredit_9EC69E9B2AF954164BA4CC83B61206E7" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLineOfCredit_9EC69E9B2AF954164BA4CC83B61206E7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayable" xlink:label="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayable_A3B2F1D55D6A757B8EAECC83B612873D" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayable_A3B2F1D55D6A757B8EAECC83B612873D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayableToRelatedParty" xlink:label="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayableToRelatedParty_FC7BCEB90D955798F998CC83B6124B68" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_ameh_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesConvertibleNotePayableToRelatedParty_FC7BCEB90D955798F998CC83B6124B68" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationAcquisitionOfLessThan100PercentNoncontrollingInterestFairValue" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionOfLessThan100PercentNoncontrollingInterestFairValue_B8CC9D8B9EB6BF9A517FCC83B612D23F" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionOfLessThan100PercentNoncontrollingInterestFairValue_B8CC9D8B9EB6BF9A517FCC83B612D23F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_CD3FDD7B8E9205C6EF62CC83B6139C3C" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_CD3FDD7B8E9205C6EF62CC83B6139C3C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_77403AC6A2267D966720CC83B6132445" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_C999578BDCF8681D8AA0CC83B6110E7A" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_77403AC6A2267D966720CC83B6132445" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_DED6CCA16902AC0BE555CC83B6139BD4" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_DED6CCA16902AC0BE555CC83B6139BD4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_A1BC6690288838067D2ACC83B613D1A2" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_A1BC6690288838067D2ACC83B613D1A2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_587B8ED47DCD90E7116ECC83B613FDC2" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_68CB7E2566E3014CA18DCC83B60F57EA" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_587B8ED47DCD90E7116ECC83B613FDC2" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillCalculatedBasedOnNumberOfSharesOfCombinedCompanyPreMergerDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillGoodwillRollForwardDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillProFormaCombinedHistoricalResultsDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillProFormaFinancialInformationAll2019AcquisitionsDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/BusinessCombinationAndGoodwillTotalPurchaseConsiderationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityLineItems" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityLineItems_AE79BF81256E4D7AC139C12C7F16A50F" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTable" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTable_BDF41D01A5F6E4BA773EC12C7F141021" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityLineItems_AE79BF81256E4D7AC139C12C7F16A50F" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTable_BDF41D01A5F6E4BA773EC12C7F141021" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_5AEA80FC1E2643CB6D04C12C7F15D755" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTable_BDF41D01A5F6E4BA773EC12C7F141021" xlink:to="loc_dei_LegalEntityAxis_5AEA80FC1E2643CB6D04C12C7F15D755" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_24B9366E95B18B557B99C12C7F15635E_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_5AEA80FC1E2643CB6D04C12C7F15D755" xlink:to="loc_dei_EntityDomain_24B9366E95B18B557B99C12C7F15635E_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_24B9366E95B18B557B99C12C7F15635E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_5AEA80FC1E2643CB6D04C12C7F15D755" xlink:to="loc_dei_EntityDomain_24B9366E95B18B557B99C12C7F15635E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_356DC63FEB3B46F367C2C12C7F15197A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_24B9366E95B18B557B99C12C7F15635E" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_356DC63FEB3B46F367C2C12C7F15197A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_C7B102DF3473529C0EFCC12C7F15751D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTable_BDF41D01A5F6E4BA773EC12C7F141021" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_C7B102DF3473529C0EFCC12C7F15751D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C7B102DF3473529C0EFCC12C7F15751D" xlink:to="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C7B102DF3473529C0EFCC12C7F15751D" xlink:to="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_583D2F8B6DBD4E152309C12C7F161629" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583" xlink:to="loc_us-gaap_PreferredStockMember_583D2F8B6DBD4E152309C12C7F161629" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_9178E61C5BDED3DCDF95C12C7F161854" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0F30BD09ED670D485F5EC12C7F166583" xlink:to="loc_us-gaap_NoncontrollingInterestMember_9178E61C5BDED3DCDF95C12C7F161854" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_D75F302627CAD1E1C3BBC12C7F16FB84" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityLineItems_AE79BF81256E4D7AC139C12C7F16A50F" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_D75F302627CAD1E1C3BBC12C7F16FB84" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1" xlink:label="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_033BABE3CB4C010B9099C12C7F17126D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityLineItems_AE79BF81256E4D7AC139C12C7F16A50F" xlink:to="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_033BABE3CB4C010B9099C12C7F17126D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_E7A26EFB43BF27A13B79C12C7F175309" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityLineItems_AE79BF81256E4D7AC139C12C7F16A50F" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_E7A26EFB43BF27A13B79C12C7F175309" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CommitmentsAndContingencies" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CommitmentsAndContingenciesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="ameh-20191231.xsd#ameh_CommitmentsAndContingenciesLineItems" xlink:label="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:type="locator"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CommitmentsAndContingenciesTable" xlink:label="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_CBA33A365A017CD98611CC83B4809D6C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_CBA33A365A017CD98611CC83B4809D6C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D65332BAB87CA086C456CC83B480F697_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CBA33A365A017CD98611CC83B4809D6C" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D65332BAB87CA086C456CC83B480F697_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D65332BAB87CA086C456CC83B480F697" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CBA33A365A017CD98611CC83B4809D6C" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D65332BAB87CA086C456CC83B480F697" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_240CE8A73042F3A19233CC83B480B9AC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D65332BAB87CA086C456CC83B480F697" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_240CE8A73042F3A19233CC83B480B9AC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_0C86C1CEB444F3931ACDCC83B4802DE3" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:to="loc_us-gaap_CreditFacilityAxis_0C86C1CEB444F3931ACDCC83B4802DE3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_357416B04FEED518DE62CC83B4804162_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_0C86C1CEB444F3931ACDCC83B4802DE3" xlink:to="loc_us-gaap_CreditFacilityDomain_357416B04FEED518DE62CC83B4804162_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_0C86C1CEB444F3931ACDCC83B4802DE3" xlink:to="loc_us-gaap_CreditFacilityDomain_357416B04FEED518DE62CC83B4804162" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StandbyLettersOfCreditMember" xlink:label="loc_us-gaap_StandbyLettersOfCreditMember_231320D0F0CDED7C5D74CC83B48F4CC7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_357416B04FEED518DE62CC83B4804162" xlink:to="loc_us-gaap_StandbyLettersOfCreditMember_231320D0F0CDED7C5D74CC83B48F4CC7" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_B569E91F8E58DB3B9CC1CC83B48FAC7C" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:to="loc_dei_LegalEntityAxis_B569E91F8E58DB3B9CC1CC83B48FAC7C" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_B569E91F8E58DB3B9CC1CC83B48FAC7C" xlink:to="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_B569E91F8E58DB3B9CC1CC83B48FAC7C" xlink:to="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_B49280D8F724451E3BF8CC83B48FE36B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_B49280D8F724451E3BF8CC83B48FE36B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_C8994AA1D206BBFC34F5CC83B48F7224" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_C8994AA1D206BBFC34F5CC83B48F7224" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcMember" xlink:label="loc_ameh_ApcMember_9D87534E55D06C8B0022CC83B48F75E1" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:to="loc_ameh_ApcMember_9D87534E55D06C8B0022CC83B48F75E1" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APCAndAPCLSMAMember" xlink:label="loc_ameh_APCAndAPCLSMAMember_C0A5951B34131833B171CC83B48F5E21" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5A7B2F1DEE1B8738175ACC83B48FB6B6" xlink:to="loc_ameh_APCAndAPCLSMAMember_C0A5951B34131833B171CC83B48F5E21" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_DC761B2FEC00585CD10ECC83B48FE34D" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:to="loc_srt_ProductOrServiceAxis_DC761B2FEC00585CD10ECC83B48FE34D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_70A2D6D2FA08BEFE3080CC83B48F94AD_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_DC761B2FEC00585CD10ECC83B48FE34D" xlink:to="loc_srt_ProductsAndServicesDomain_70A2D6D2FA08BEFE3080CC83B48F94AD_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_70A2D6D2FA08BEFE3080CC83B48F94AD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_DC761B2FEC00585CD10ECC83B48FE34D" xlink:to="loc_srt_ProductsAndServicesDomain_70A2D6D2FA08BEFE3080CC83B48F94AD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PreferredBankMember" xlink:label="loc_ameh_PreferredBankMember_04D5930B2BB6C9E0D334CC83B48F729E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_70A2D6D2FA08BEFE3080CC83B48F94AD" xlink:to="loc_ameh_PreferredBankMember_04D5930B2BB6C9E0D334CC83B48F729E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialSupportToNonconsolidatedLegalEntityAxis" xlink:label="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityAxis_62812CC8BE9DB36CAA10CC83B48FF76E" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_CommitmentsAndContingenciesTable_7FFB31329E054F533091CC83B480A759" xlink:to="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityAxis_62812CC8BE9DB36CAA10CC83B48FF76E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialSupportToNonconsolidatedLegalEntityDomain" xlink:label="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityDomain_3F595F8175F8F176FF8CCC83B48F8C78_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityAxis_62812CC8BE9DB36CAA10CC83B48FF76E" xlink:to="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityDomain_3F595F8175F8F176FF8CCC83B48F8C78_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityAxis_62812CC8BE9DB36CAA10CC83B48FF76E" xlink:to="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityDomain_3F595F8175F8F176FF8CCC83B48F8C78" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StandbyLettersOfCreditMember" xlink:label="loc_us-gaap_StandbyLettersOfCreditMember_C16035A6FFDB95003AD2CC83B48F3BB6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialSupportToNonconsolidatedLegalEntityDomain_3F595F8175F8F176FF8CCC83B48F8C78" xlink:to="loc_us-gaap_StandbyLettersOfCreditMember_C16035A6FFDB95003AD2CC83B48F3BB6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PercentageOfFinancialGuaranteeBenchmarkAmount" xlink:label="loc_ameh_PercentageOfFinancialGuaranteeBenchmarkAmount_04EEA6B1A4C849551C97CC83B48F2EDF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_ameh_PercentageOfFinancialGuaranteeBenchmarkAmount_04EEA6B1A4C849551C97CC83B48F2EDF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_D12EDDA16ECDFBC358C0CC83B48F75FD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_LineOfCredit_D12EDDA16ECDFBC358C0CC83B48F75FD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingencyDamagesSoughtValue" xlink:label="loc_us-gaap_LossContingencyDamagesSoughtValue_26C5B75CB842010BC9A1CC83B48F1DFF" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_LossContingencyDamagesSoughtValue_26C5B75CB842010BC9A1CC83B48F1DFF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities_957B6708407424F87788CC83B48F5314" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinancialLiabilities_957B6708407424F87788CC83B48F5314" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityExpirationPeriod" xlink:label="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_EB767010A0B8244F4683CC83B48F2867" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_EB767010A0B8244F4683CC83B48F2867" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_EF1056D7029F033213CCCC83B48F07F8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_EF1056D7029F033213CCCC83B48F07F8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased" xlink:label="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_AE7F18721B32368BCF9ECC83B48F9C39" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_AE7F18721B32368BCF9ECC83B48F9C39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SettlementLiabilitiesCurrent" xlink:label="loc_us-gaap_SettlementLiabilitiesCurrent_6DAE87EB695F3B33E4FDCC83B48F2CB1" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_CommitmentsAndContingenciesLineItems_E599A428534241ED782DCC83B48F9671" xlink:to="loc_us-gaap_SettlementLiabilitiesCurrent_6DAE87EB695F3B33E4FDCC83B48F2CB1" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedBalanceSheets" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6C27C038C2E93BC74A65C4DD14974A36" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_5F1E365841673C2B8BE8C4DD1496D91F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_6C27C038C2E93BC74A65C4DD14974A36" xlink:to="loc_us-gaap_StatementTable_5F1E365841673C2B8BE8C4DD1496D91F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_27E359A33090C52361F4C4DD149648B7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_5F1E365841673C2B8BE8C4DD1496D91F" xlink:to="loc_us-gaap_StatementClassOfStockAxis_27E359A33090C52361F4C4DD149648B7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_27E359A33090C52361F4C4DD149648B7" xlink:to="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_27E359A33090C52361F4C4DD149648B7" xlink:to="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_0EE84F08FA3D2DCE4CBDC4DD1496CC8B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_0EE84F08FA3D2DCE4CBDC4DD1496CC8B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_8359A191E5B1F20253D7C4DD149726E8" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_898DA8DAC16C27FC4659C4DD1496E4D4" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_8359A191E5B1F20253D7C4DD149726E8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_9E6F601A14D47DACDEA9C4DD14978B4F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6C27C038C2E93BC74A65C4DD14974A36" xlink:to="loc_us-gaap_AssetsAbstract_9E6F601A14D47DACDEA9C4DD14978B4F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_9E6F601A14D47DACDEA9C4DD14978B4F" xlink:to="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4C64A69B0CB167027C74C4DD1498A79D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4C64A69B0CB167027C74C4DD1498A79D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashCurrent" xlink:label="loc_us-gaap_RestrictedCashCurrent_52A1DBE4C99E61FFED1DC4DD14986A58" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_RestrictedCashCurrent_52A1DBE4C99E61FFED1DC4DD14986A58" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_3AB4051CF025853A6098C4DD149806C2" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_3AB4051CF025853A6098C4DD149806C2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_108EBCBB5B08DF4C1F30C4DD1498AE07" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_108EBCBB5B08DF4C1F30C4DD1498AE07" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_F18F66D5C0D41DB657CAC4DD14987990" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_F18F66D5C0D41DB657CAC4DD14987990" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherReceivablesNetCurrent" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_08CCC0C8D5236C951B86C4DD1499A5A2" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_08CCC0C8D5236C951B86C4DD1499A5A2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_4E87EC2D9EF592CB3F5AC4DD1499E540" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_4E87EC2D9EF592CB3F5AC4DD1499E540" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesAndLoansReceivableNetCurrent" xlink:label="loc_us-gaap_NotesAndLoansReceivableNetCurrent_FAE51EFA852394A71936C4DD149992D0" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_NotesAndLoansReceivableNetCurrent_FAE51EFA852394A71936C4DD149992D0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_NotesReceivableRelatedPartiesCurrent_6D7921834E6F907FD698C4DD149947AA" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_NotesReceivableRelatedPartiesCurrent_6D7921834E6F907FD698C4DD149947AA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_48212990E0A458AD5253C4DD14990CE0" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_5DE8FDF9466D66B10ED7C4DD14974769" xlink:to="loc_us-gaap_AssetsCurrent_48212990E0A458AD5253C4DD14990CE0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_9E6F601A14D47DACDEA9C4DD14978B4F" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:label="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_9516184840D129B3791CC4DD14990A8D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_9516184840D129B3791CC4DD14990A8D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_C12CD6956CEA99E43773C4DD149A183B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_C12CD6956CEA99E43773C4DD149A183B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8ABD9BE36CD5287D2B26C4DD149A5C42" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8ABD9BE36CD5287D2B26C4DD149A5C42" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_8CA8A4ACF88FFD1ED7BCC4DD149AE61F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_Goodwill_8CA8A4ACF88FFD1ED7BCC4DD149AE61F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DueFromRelatedPartiesNoncurrent" xlink:label="loc_us-gaap_DueFromRelatedPartiesNoncurrent_A9CE891BA01374508E20C4DD149A922B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_DueFromRelatedPartiesNoncurrent_A9CE891BA01374508E20C4DD149A922B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="loc_us-gaap_EquityMethodInvestments_098EA4D3B891A69ABA67C4DD149A443A" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_EquityMethodInvestments_098EA4D3B891A69ABA67C4DD149A443A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_InvestmentInPrivatelyHeldEntityThatDoesNotReportNetAssetValue" xlink:label="loc_ameh_InvestmentInPrivatelyHeldEntityThatDoesNotReportNetAssetValue_5068FCF67EEA770D6723C4DD149A1950" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_ameh_InvestmentInPrivatelyHeldEntityThatDoesNotReportNetAssetValue_5068FCF67EEA770D6723C4DD149A1950" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashNoncurrent" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_D95603299B67515EB1AAC4DD149BE3E0" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_D95603299B67515EB1AAC4DD149BE3E0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_41FD3D4525345894DB42C4DD149BD005" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_41FD3D4525345894DB42C4DD149BD005" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_A388DF4FD7909EA7D3C1C4DD149B1423" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_A388DF4FD7909EA7D3C1C4DD149B1423" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsNoncurrent" xlink:label="loc_us-gaap_AssetsNoncurrent_840D0372C516BD7D2ACEC4DD149B0016" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_81A2D9AC2DDA641B6449C4DD1499340D" xlink:to="loc_us-gaap_AssetsNoncurrent_840D0372C516BD7D2ACEC4DD149B0016" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_82A2F5A198FC2EB64278C4DD149B3E93" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_9E6F601A14D47DACDEA9C4DD14978B4F" xlink:to="loc_us-gaap_Assets_82A2F5A198FC2EB64278C4DD149B3E93" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6C27C038C2E93BC74A65C4DD14974A36" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_668968252E5FD901587AC4DD149C6066" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_668968252E5FD901587AC4DD149C6066" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FiduciaryAccountsPayableCurrent" xlink:label="loc_ameh_FiduciaryAccountsPayableCurrent_8292C6B15A4524960B16C4DD149C7713" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_ameh_FiduciaryAccountsPayableCurrent_8292C6B15A4524960B16C4DD149C7713" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicalLiabilitiesCurrent" xlink:label="loc_ameh_MedicalLiabilitiesCurrent_DD8A32442AF9F4A6295CC4DD149C9ACF" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_ameh_MedicalLiabilitiesCurrent_DD8A32442AF9F4A6295CC4DD149C9ACF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_F99A8FB5DCD19707D435C4DD149D4DA4" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_F99A8FB5DCD19707D435C4DD149D4DA4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermBankLoansAndNotesPayable" xlink:label="loc_us-gaap_ShortTermBankLoansAndNotesPayable_92215032FD4307045A55C4DD149D02EA" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_ShortTermBankLoansAndNotesPayable_92215032FD4307045A55C4DD149D02EA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaap_DividendsPayableCurrent_10F2BAD8DACC3427F34AC4DD149D9A22" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_DividendsPayableCurrent_10F2BAD8DACC3427F34AC4DD149D9A22" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_E1A73AC993C1EDE46466C4DD149DBEFC" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_E1A73AC993C1EDE46466C4DD149DBEFC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_CEBC25938A7C41DF25A2C4DD149D5AB6" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_CEBC25938A7C41DF25A2C4DD149D5AB6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_08031E0F908A61A71B7DC4DD149DA229" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_LongTermDebtCurrent_08031E0F908A61A71B7DC4DD149DA229" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_553323FF0BD1CE161874C4DD149E1B60" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_1FC0F21336F44A02036BC4DD149CEAD7" xlink:to="loc_us-gaap_LiabilitiesCurrent_553323FF0BD1CE161874C4DD149E1B60" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DueToRelatedPartiesNoncurrent" xlink:label="loc_us-gaap_DueToRelatedPartiesNoncurrent_1D8C78B464488499BCCAC4DD149EE254" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_DueToRelatedPartiesNoncurrent_1D8C78B464488499BCCAC4DD149EE254" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_7CE98BE7F09ECDF31D3CC4DD149E24CD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_7CE98BE7F09ECDF31D3CC4DD149E24CD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LiabilityForUnissuedEquitySharesNoncurrent" xlink:label="loc_ameh_LiabilityForUnissuedEquitySharesNoncurrent_4B632A751C91DEB0B4EFC4DD149EF030" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_ameh_LiabilityForUnissuedEquitySharesNoncurrent_4B632A751C91DEB0B4EFC4DD149EF030" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_58BAB03F071846DA6E6BC4DD149E7B5B" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_58BAB03F071846DA6E6BC4DD149E7B5B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeaseObligationsNoncurrent" xlink:label="loc_us-gaap_CapitalLeaseObligationsNoncurrent_B6DD1EB49DFAD92D2134C4FD99E41AF5" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_CapitalLeaseObligationsNoncurrent_B6DD1EB49DFAD92D2134C4FD99E41AF5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_6AC6F6C7188C63DDC760C4DD149F754F" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_6AC6F6C7188C63DDC760C4DD149F754F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_24DCA4DABC23B017A48BC4DD149FBF9D" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_24DCA4DABC23B017A48BC4DD149FBF9D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_E7375079E972A8EB42D3C4DD149F0230" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E07D61590CDD0F971A4C4DD149E3A15" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_E7375079E972A8EB42D3C4DD149F0230" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_BEDAB9527C9931058E01C4DD149F1CC7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_Liabilities_BEDAB9527C9931058E01C4DD149F1CC7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_452000902AC78A680526C4DD149F170F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_CommitmentsAndContingencies_452000902AC78A680526C4DD149F170F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MezzanineEquityAbstract" xlink:label="loc_ameh_MezzanineEquityAbstract_7D841F78344A596E4D8FC4DD149F7F73" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_ameh_MezzanineEquityAbstract_7D841F78344A596E4D8FC4DD149F7F73" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_C78157A179C981673052C4DD14A0143B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_MezzanineEquityAbstract_7D841F78344A596E4D8FC4DD149F7F73" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_C78157A179C981673052C4DD14A0143B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_A5A006BF34134EB12EB9C4DD14A00728" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_PreferredStockValue_A5A006BF34134EB12EB9C4DD14A00728" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_4F715A1DA889571690BDC4DD14A0B4AE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_CommonStockValue_4F715A1DA889571690BDC4DD14A0B4AE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_E875802279F5FEFAC92CC4DD14A00CBC" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_AdditionalPaidInCapital_E875802279F5FEFAC92CC4DD14A00CBC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_CC5872C2A61664E22A25C4DD14A12CDB" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_CC5872C2A61664E22A25C4DD14A12CDB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_7648929C17AB7E36965BC4DD14A144F8" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_StockholdersEquity_7648929C17AB7E36965BC4DD14A144F8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_089CF1EA3E74D4C330B9C4DD14A1DA39" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_MinorityInterest_089CF1EA3E74D4C330B9C4DD14A1DA39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_BDE85062D33581FBFA8AC4DD14A1E456" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0DA6607CD4B18339A322C4DD14A09049" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_BDE85062D33581FBFA8AC4DD14A1E456" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_7CB6F219249824DAA245C4DD14A13F2E" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A6DE4E5BA81ED730FEE4C4DD149B2F9A" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_7CB6F219249824DAA245C4DD14A13F2E" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_8D416D7C6211ABA747C7C13797302FAD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_StatementTable_8D416D7C6211ABA747C7C13797302FAD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_08D68B09E4C5E9222266C1379730167E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_8D416D7C6211ABA747C7C13797302FAD" xlink:to="loc_us-gaap_StatementClassOfStockAxis_08D68B09E4C5E9222266C1379730167E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_08D68B09E4C5E9222266C1379730167E" xlink:to="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_08D68B09E4C5E9222266C1379730167E" xlink:to="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_294902215761E6E6B85DC13797302CE9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_294902215761E6E6B85DC13797302CE9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_0059C47CC648B411E527C137973167BD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_FAA7936D45203640BAD0C13797302779" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_0059C47CC648B411E527C137973167BD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_7F9B26870A30E6F0657BC1379731DE23" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_7F9B26870A30E6F0657BC1379731DE23" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_107B68B127D6993D65B7C13797314240" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_107B68B127D6993D65B7C13797314240" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_BD5BCE381BAF926BF128C13797319FF7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_PreferredStockSharesIssued_BD5BCE381BAF926BF128C13797319FF7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_A0B1A1754EFC9FD43D6AC13797321451" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_A0B1A1754EFC9FD43D6AC13797321451" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_8569CD7F4D09D7F94B84C1379732D63A" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_8569CD7F4D09D7F94B84C1379732D63A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_E964F4BE909C5B6E867EC1379732EEA2" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_E964F4BE909C5B6E867EC1379732EEA2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_C3F62370CF48561F2E09C1379732F004" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_C3F62370CF48561F2E09C1379732F004" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockCommonShares" xlink:label="loc_us-gaap_TreasuryStockCommonShares_C54B198B3E514B1A9A54C13797323B59" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_BCD8430C87A0E8ACAA87C13797316EBB" xlink:to="loc_us-gaap_TreasuryStockCommonShares_C54B198B3E514B1A9A54C13797323B59" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_05EEDC934DB3C9C0B9C4D978FBBA6F4C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_05EEDC934DB3C9C0B9C4D978FBBA6F4C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_C3131BF7DC43630A7F0ED978FBBA5663_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_05EEDC934DB3C9C0B9C4D978FBBA6F4C" xlink:to="loc_us-gaap_RelatedPartyDomain_C3131BF7DC43630A7F0ED978FBBA5663_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_C3131BF7DC43630A7F0ED978FBBA5663" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_05EEDC934DB3C9C0B9C4D978FBBA6F4C" xlink:to="loc_us-gaap_RelatedPartyDomain_C3131BF7DC43630A7F0ED978FBBA5663" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_7F2F70D67659B5E3E13BD978FBBB7F20" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_C3131BF7DC43630A7F0ED978FBBA5663" xlink:to="loc_srt_AffiliatedEntityMember_7F2F70D67659B5E3E13BD978FBBB7F20" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_9111E678B0AE82F28F5AD978FBBB5908" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:to="loc_srt_CounterpartyNameAxis_9111E678B0AE82F28F5AD978FBBB5908" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01CEAFD60F9B7EC1C6BBD978FBBB0214_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_9111E678B0AE82F28F5AD978FBBB5908" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01CEAFD60F9B7EC1C6BBD978FBBB0214_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01CEAFD60F9B7EC1C6BBD978FBBB0214" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_9111E678B0AE82F28F5AD978FBBB5908" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01CEAFD60F9B7EC1C6BBD978FBBB0214" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_9FCA912691DE1349EDC8D978FBBBD272" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01CEAFD60F9B7EC1C6BBD978FBBB0214" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_9FCA912691DE1349EDC8D978FBBBD272" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_C637434E6ACDE32F136DD978FBBC55C7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_C637434E6ACDE32F136DD978FBBC55C7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7563F64ACD6A225C0539D978FBBC7361_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C637434E6ACDE32F136DD978FBBC55C7" xlink:to="loc_us-gaap_EquityComponentDomain_7563F64ACD6A225C0539D978FBBC7361_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7563F64ACD6A225C0539D978FBBC7361" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C637434E6ACDE32F136DD978FBBC55C7" xlink:to="loc_us-gaap_EquityComponentDomain_7563F64ACD6A225C0539D978FBBC7361" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_8C5E7925A82220EED9EFD978FBBCD059" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7563F64ACD6A225C0539D978FBBC7361" xlink:to="loc_us-gaap_PreferredStockMember_8C5E7925A82220EED9EFD978FBBCD059" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_A45037D7C213B9BF8B4AD978FBBCA187" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:to="loc_dei_LegalEntityAxis_A45037D7C213B9BF8B4AD978FBBCA187" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_1879539EAFCA80226216D978FBBCC1EC_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_A45037D7C213B9BF8B4AD978FBBCA187" xlink:to="loc_dei_EntityDomain_1879539EAFCA80226216D978FBBCC1EC_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_1879539EAFCA80226216D978FBBCC1EC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_A45037D7C213B9BF8B4AD978FBBCA187" xlink:to="loc_dei_EntityDomain_1879539EAFCA80226216D978FBBCC1EC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_561162DD119535172320D978FBBD5327" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_1879539EAFCA80226216D978FBBCC1EC" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_561162DD119535172320D978FBBD5327" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_556BB4346097EED48A66D978FBBD22EC" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FA4760E508048F53FA64D978FBBA511B" xlink:to="loc_us-gaap_AwardTypeAxis_556BB4346097EED48A66D978FBBD22EC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4B3B09274A5F418CDA82D978FBBD9308_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_556BB4346097EED48A66D978FBBD22EC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4B3B09274A5F418CDA82D978FBBD9308_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_556BB4346097EED48A66D978FBBD22EC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4B3B09274A5F418CDA82D978FBBD9308" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UnvestedStockCompensationMember" xlink:label="loc_ameh_UnvestedStockCompensationMember_365A43AADB60377B83D2D978FBBD5E0C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4B3B09274A5F418CDA82D978FBBD9308" xlink:to="loc_ameh_UnvestedStockCompensationMember_365A43AADB60377B83D2D978FBBD5E0C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_ED8B600FE574A1604B96D978FBBED1FB" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_ED8B600FE574A1604B96D978FBBED1FB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_9889D5748B76080F7FBDD978FBBE953E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_ED8B600FE574A1604B96D978FBBED1FB" xlink:to="loc_us-gaap_ProfitLoss_9889D5748B76080F7FBDD978FBBE953E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_ED8B600FE574A1604B96D978FBBED1FB" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_0E60B7F6BC92656D94BED978FBBFE6B3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_0E60B7F6BC92656D94BED978FBBFE6B3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_951D0F9AC72F898EFBE8D978FBBF6164" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_951D0F9AC72F898EFBE8D978FBBF6164" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_267352FBC1022BD65D8DD978FBBFA195" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_267352FBC1022BD65D8DD978FBBFA195" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_B23CA0978E4DAB0DE931D978FBBF30A9" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_B23CA0978E4DAB0DE931D978FBBF30A9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_DF92442957E55A24571CD978FBC0D371" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_ShareBasedCompensation_DF92442957E55A24571CD978FBC0D371" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_GainLossOnAssumptionOfLoan" xlink:label="loc_ameh_GainLossOnAssumptionOfLoan_7232222D59B2B3CEDE93D978FBC07EAE" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_ameh_GainLossOnAssumptionOfLoan_7232222D59B2B3CEDE93D978FBC07EAE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_86DCC5561308AD23F438D978FBC0EAC6" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_86DCC5561308AD23F438D978FBC0EAC6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfNotesReceivable" xlink:label="loc_us-gaap_GainLossOnSaleOfNotesReceivable_E9E81403925837973A68D978FBC01FED" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_GainLossOnSaleOfNotesReceivable_E9E81403925837973A68D978FBC01FED" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_90E3408C9AC792F0F89AD978FBC0EBDD" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_GainLossOnInvestments_90E3408C9AC792F0F89AD978FBC0EBDD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_82375334C778E077762AD978FBC03A5C" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_82375334C778E077762AD978FBC03A5C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_355B166CEEC58935E6B5D978FBC0CB9B" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_355B166CEEC58935E6B5D978FBC0CB9B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_41CAA59F138A4CACF706D978FBC11FC6" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_41CAA59F138A4CACF706D978FBC11FC6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C090C43BFD1964DFC277D978FBBFBBB0" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_96D98372A2B9E9FB64A4D978FBC1D96D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_96D98372A2B9E9FB64A4D978FBC1D96D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedParties" xlink:label="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_E7A9B34A54C0D9E2896AD978FBC10A9C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_E7A9B34A54C0D9E2896AD978FBC10A9C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_4B6935269FC6D8CBF727D978FBC10D07" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_4B6935269FC6D8CBF727D978FBC10D07" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInPrepaidExpensesAndOtherCurrentAssets" xlink:label="loc_ameh_IncreaseDecreaseInPrepaidExpensesAndOtherCurrentAssets_D285D84EED1F70F46F85D978FBC205AE" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_ameh_IncreaseDecreaseInPrepaidExpensesAndOtherCurrentAssets_D285D84EED1F70F46F85D978FBC205AE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInOperatingLeaseAssets" xlink:label="loc_ameh_IncreaseDecreaseInOperatingLeaseAssets_683A1C35078D68F6CB52D978FBC25E38" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_ameh_IncreaseDecreaseInOperatingLeaseAssets_683A1C35078D68F6CB52D978FBC25E38" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_920B1A6BCBBD1A2D3584D978FBC2F70D" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_920B1A6BCBBD1A2D3584D978FBC2F70D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_6ACCA2D698D9FAC48F75D978FBC20419" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_6ACCA2D698D9FAC48F75D978FBC20419" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayable_AA707FF74D695E3F4C8AD978FBC25ED5" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayable_AA707FF74D695E3F4C8AD978FBC25ED5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInCapitationIncentivesPayable" xlink:label="loc_ameh_IncreaseDecreaseInCapitationIncentivesPayable_EDF5536913BAC7AB3046D978FBC2A309" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_ameh_IncreaseDecreaseInCapitationIncentivesPayable_EDF5536913BAC7AB3046D978FBC2A309" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInMedicalLiabilities" xlink:label="loc_ameh_IncreaseDecreaseInMedicalLiabilities_8F4E1A853430B5949813D978FBC3AC4F" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_ameh_IncreaseDecreaseInMedicalLiabilities_8F4E1A853430B5949813D978FBC3AC4F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_BB1CA523A16001B8A2C7D978FBC32069" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_BB1CA523A16001B8A2C7D978FBC32069" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInOtherOperatingLeaseLiabilities" xlink:label="loc_ameh_IncreaseDecreaseInOtherOperatingLeaseLiabilities_F7638E771D45ED263F3AD978FBC314BF" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9C726F8F1D57FC375AB4D978FBC1443D" xlink:to="loc_ameh_IncreaseDecreaseInOtherOperatingLeaseLiabilities_F7638E771D45ED263F3AD978FBC314BF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_CF30A0C5314B5F50F78CD978FBC30A5F" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_ED8B600FE574A1604B96D978FBBED1FB" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_CF30A0C5314B5F50F78CD978FBC30A5F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAcquiredFromAcquisition" xlink:label="loc_us-gaap_CashAcquiredFromAcquisition_8D23459EF14176E4E5BCD978FBC309FF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_CashAcquiredFromAcquisition_8D23459EF14176E4E5BCD978FBC309FF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates" xlink:label="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_6CB992D28332B84B58F2D978FBC48046" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_6CB992D28332B84B58F2D978FBC48046" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8B2323344841BCD84EA2D978FBC4FAB7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8B2323344841BCD84EA2D978FBC4FAB7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfLoansReceivable" xlink:label="loc_us-gaap_ProceedsFromSaleOfLoansReceivable_33467FB9C7310F3D2CB8D978FBC4C6A5" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_ProceedsFromSaleOfLoansReceivable_33467FB9C7310F3D2CB8D978FBC4C6A5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToFundLongtermLoansToRelatedParties" xlink:label="loc_us-gaap_PaymentsToFundLongtermLoansToRelatedParties_ADE62C2BB39E69CEFF50D978FBC499B8" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsToFundLongtermLoansToRelatedParties_ADE62C2BB39E69CEFF50D978FBC499B8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital" xlink:label="loc_us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_D2DC8A684CB28EA2D53CD978FBC405FD" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_D2DC8A684CB28EA2D53CD978FBC405FD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ProceedsOnSaleOfInvestmentPrivatelyHeldEntityThatDoesNotReportNAVPershare" xlink:label="loc_ameh_ProceedsOnSaleOfInvestmentPrivatelyHeldEntityThatDoesNotReportNAVPershare_272022D1CE1D1700FA9BD978FBC4DD69" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_ameh_ProceedsOnSaleOfInvestmentPrivatelyHeldEntityThatDoesNotReportNAVPershare_272022D1CE1D1700FA9BD978FBC4DD69" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_CAAFB510D2EA29DEFF0DD978FBC59EA0" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_CAAFB510D2EA29DEFF0DD978FBC59EA0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentOfInvestmentPrivatelyHeldEntityDoesNotReportToNAVPerShare" xlink:label="loc_ameh_PaymentOfInvestmentPrivatelyHeldEntityDoesNotReportToNAVPerShare_5EB24330543CDC2CC9E3D978FBC5D85F" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_ameh_PaymentOfInvestmentPrivatelyHeldEntityDoesNotReportToNAVPerShare_5EB24330543CDC2CC9E3D978FBC5D85F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_47737B9791060623845ED978FBC508B9" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_47737B9791060623845ED978FBC508B9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_4A94D45E5DB4A74CA972D978FBC5AFE4" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_4A94D45E5DB4A74CA972D978FBC5AFE4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1B8F85D030A1A140A8FFD978FBC51A21" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_9FF661F520789753C4FED978FBC3FAB4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1B8F85D030A1A140A8FFD978FBC51A21" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_97D2905A9A628FAA94B1D978FBC5EBAE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_PaymentsOfDividends_97D2905A9A628FAA94B1D978FBC5EBAE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromPaymentsToMinorityShareholders" xlink:label="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_1523D8E9884A297B30EED978FBC6CA39" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromPaymentsToMinorityShareholders_1523D8E9884A297B30EED978FBC6CA39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_B4A84250A8D1BEC93732D978FBC6254B" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_B4A84250A8D1BEC93732D978FBC6254B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromLongTermLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_A156EEFD4D4ED8189D2AD978FBC64F27" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_A156EEFD4D4ED8189D2AD978FBC64F27" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_B10DCC47F006C309CF06D978FBC66590" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_B10DCC47F006C309CF06D978FBC66590" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_54FB56F80182B56023E5D978FBC6EEE8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_54FB56F80182B56023E5D978FBC6EEE8" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_RepaymentsOfBankLoanAndLinesOfCredit" xlink:label="loc_ameh_RepaymentsOfBankLoanAndLinesOfCredit_C892060F01D50D6EE6C4D978FBC76525" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_ameh_RepaymentsOfBankLoanAndLinesOfCredit_C892060F01D50D6EE6C4D978FBC76525" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfDebtAndCapitalLeaseObligations" xlink:label="loc_us-gaap_RepaymentsOfDebtAndCapitalLeaseObligations_E3DDDB9B1EFAF07536C5D978FBC79E64" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_RepaymentsOfDebtAndCapitalLeaseObligations_E3DDDB9B1EFAF07536C5D978FBC79E64" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ProceedsFromStockOptionsExercisedIncludedInLiabilities" xlink:label="loc_ameh_ProceedsFromStockOptionsExercisedIncludedInLiabilities_B5597592138E3F935979D978FBC7BA3F" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_ameh_ProceedsFromStockOptionsExercisedIncludedInLiabilities_B5597592138E3F935979D978FBC7BA3F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromWarrantExercises" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_93B4A16731E8108EFAFBD978FBC747CE" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_93B4A16731E8108EFAFBD978FBC747CE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_23E9FF3D3AFFE4289C25D978FBC7AFE3" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_23E9FF3D3AFFE4289C25D978FBC7AFE3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5528A59C207FF13FE678D978FBC7B5BD" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5528A59C207FF13FE678D978FBC7B5BD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentOfFinancingAndStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentOfFinancingAndStockIssuanceCosts_008AAD76C94AD504629DD978FBC71B94" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_PaymentOfFinancingAndStockIssuanceCosts_008AAD76C94AD504629DD978FBC71B94" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_B30D08086DE8A4A9F51AD978FBC858EB" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_DDDAE6F1067A0A22C709D978FBC590E6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_B30D08086DE8A4A9F51AD978FBC858EB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_F894EC2337594F4B605DD978FBC879F8" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_F894EC2337594F4B605DD978FBC879F8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_55B6FC7AC271B345AF60D978FBC816E6" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_55B6FC7AC271B345AF60D978FBC816E6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_22BF70F8E515A1CCAE0FD978FBC8CF44" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_22BF70F8E515A1CCAE0FD978FBC8CF44" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_1FCEA169DB9D8323CBF2D978FBC94477" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_22BF70F8E515A1CCAE0FD978FBC8CF44" xlink:to="loc_us-gaap_IncomeTaxesPaid_1FCEA169DB9D8323CBF2D978FBC94477" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_B48DF11CD4F2FBFBECE5D978FBC94F56" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_22BF70F8E515A1CCAE0FD978FBC8CF44" xlink:to="loc_us-gaap_InterestPaidNet_B48DF11CD4F2FBFBECE5D978FBC94F56" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CashlessExerciseOfStockOptions" xlink:label="loc_ameh_CashlessExerciseOfStockOptions_84E2081EA76CD6B4DE91D978FBC90F1B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_CashlessExerciseOfStockOptions_84E2081EA76CD6B4DE91D978FBC90F1B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_1DD9345055B6B13282CED978FBC97FE8" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_1DD9345055B6B13282CED978FBC97FE8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_1D328C6E2EBE75C06E38D978FBC98F6E" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_us-gaap_StockIssued1_1D328C6E2EBE75C06E38D978FBC98F6E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DeferredTaxLiabilityAdjustedToGoodwill" xlink:label="loc_ameh_DeferredTaxLiabilityAdjustedToGoodwill_9B7265069C768452E7FBD978FBCA7911" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_DeferredTaxLiabilityAdjustedToGoodwill_9B7265069C768452E7FBD978FBCA7911" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ReclassificationOfLiabilityForEquity" xlink:label="loc_ameh_ReclassificationOfLiabilityForEquity_477B9BA19D25B72587CED978FBCA6A11" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_ReclassificationOfLiabilityForEquity_477B9BA19D25B72587CED978FBCA6A11" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions" xlink:label="loc_ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions_2D357BCC6F28E1D22C43D978FBCA5191" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_PurchasePriceAdjustmentforAccelerationofVestedStockOptions_2D357BCC6F28E1D22C43D978FBCA5191" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NoncashorPartNoncashAcquisitionConversionofLoanReceivabletoInvestmentInterest" xlink:label="loc_ameh_NoncashorPartNoncashAcquisitionConversionofLoanReceivabletoInvestmentInterest_D7D035D6528F07A69C11D978FBCAC2C6" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_NoncashorPartNoncashAcquisitionConversionofLoanReceivabletoInvestmentInterest_D7D035D6528F07A69C11D978FBCAC2C6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ReclassificationOfDividendsRelatedToSharesRepurchase" xlink:label="loc_ameh_ReclassificationOfDividendsRelatedToSharesRepurchase_F5EAEE48595BC0AC5B0AD978FBCA76E8" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_ReclassificationOfDividendsRelatedToSharesRepurchase_F5EAEE48595BC0AC5B0AD978FBCA76E8" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ReclassificationOfAPSNonControllingInterestToEquity" xlink:label="loc_ameh_ReclassificationOfAPSNonControllingInterestToEquity_105B90DA6ECC28ACFBB8D978FBCA98F6" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_ReclassificationOfAPSNonControllingInterestToEquity_105B90DA6ECC28ACFBB8D978FBCA98F6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentOfWarrantsGrantedForServices" xlink:label="loc_us-gaap_AdjustmentOfWarrantsGrantedForServices_18BDC2A2128D311F0261D978FBCB9223" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_us-gaap_AdjustmentOfWarrantsGrantedForServices_18BDC2A2128D311F0261D978FBCB9223" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConversionOfStockAmountIssued1" xlink:label="loc_us-gaap_ConversionOfStockAmountIssued1_B9EEFAC5B457FBF8C1EFD978FBCB277D" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_us-gaap_ConversionOfStockAmountIssued1_B9EEFAC5B457FBF8C1EFD978FBCB277D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ReclassificationOfLiabilityForUnissuedCommonSharesPayableToEquity" xlink:label="loc_ameh_ReclassificationOfLiabilityForUnissuedCommonSharesPayableToEquity_C1D59F937CBE82E28F89D978FBCBBC3D" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_ameh_ReclassificationOfLiabilityForUnissuedCommonSharesPayableToEquity_C1D59F937CBE82E28F89D978FBCBBC3D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NoncashOrPartNoncashDivestitureAmountOfConsiderationReceived1" xlink:label="loc_us-gaap_NoncashOrPartNoncashDivestitureAmountOfConsiderationReceived1_F6D41E02906A452F5E74D978FBCB0779" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_4610686CFEFF6A8ABC4BD978FBC9FB85" xlink:to="loc_us-gaap_NoncashOrPartNoncashDivestitureAmountOfConsiderationReceived1_F6D41E02906A452F5E74D978FBCB0779" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract" xlink:label="loc_ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract_6FA076CFD7DE973A609BD978FBCB7A4A" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DE077370AA1A567B75DBD978FBBE5C99" xlink:to="loc_ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract_6FA076CFD7DE973A609BD978FBCB7A4A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_E0AFA68740B4F55C3591D978FBCB3786" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract_6FA076CFD7DE973A609BD978FBCB7A4A" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_E0AFA68740B4F55C3591D978FBCB3786" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashEquivalentsNoncurrent" xlink:label="loc_us-gaap_RestrictedCashEquivalentsNoncurrent_3A9E6B53C374C8F449C3D978FBCCC842" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract_6FA076CFD7DE973A609BD978FBCB7A4A" xlink:to="loc_us-gaap_RestrictedCashEquivalentsNoncurrent_3A9E6B53C374C8F449C3D978FBCCC842" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashEquivalentsCurrent" xlink:label="loc_us-gaap_RestrictedCashEquivalentsCurrent_169B80B2C5F2313E8D1CD978FBCC1EFA" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract_6FA076CFD7DE973A609BD978FBCB7A4A" xlink:to="loc_us-gaap_RestrictedCashEquivalentsCurrent_169B80B2C5F2313E8D1CD978FBCC1EFA" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_89FFBABBEF1868444E67CF3612524F1F" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_4070C0A790E2A592A7ADCF361250614A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_89FFBABBEF1868444E67CF3612524F1F" xlink:to="loc_us-gaap_StatementTable_4070C0A790E2A592A7ADCF361250614A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_73D34C81783FF8266EF4CF69C9CA3AA6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4070C0A790E2A592A7ADCF361250614A" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_73D34C81783FF8266EF4CF69C9CA3AA6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0F493E0CA284D674E862CF69C9E5C9FC_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_73D34C81783FF8266EF4CF69C9CA3AA6" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0F493E0CA284D674E862CF69C9E5C9FC_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0F493E0CA284D674E862CF69C9E5C9FC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_73D34C81783FF8266EF4CF69C9CA3AA6" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0F493E0CA284D674E862CF69C9E5C9FC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApaAcoIncMember" xlink:label="loc_ameh_ApaAcoIncMember_BE19A6F8974A9580B66ACF6A1C33CA41" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_0F493E0CA284D674E862CF69C9E5C9FC" xlink:to="loc_ameh_ApaAcoIncMember_BE19A6F8974A9580B66ACF6A1C33CA41" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_80CB4115DD5ECFA8E2F8CF361250CD3C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4070C0A790E2A592A7ADCF361250614A" xlink:to="loc_dei_LegalEntityAxis_80CB4115DD5ECFA8E2F8CF361250CD3C" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_EED8ECA6B51861CA76E9CF36125166D6_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_80CB4115DD5ECFA8E2F8CF361250CD3C" xlink:to="loc_dei_EntityDomain_EED8ECA6B51861CA76E9CF36125166D6_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_EED8ECA6B51861CA76E9CF36125166D6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_80CB4115DD5ECFA8E2F8CF361250CD3C" xlink:to="loc_dei_EntityDomain_EED8ECA6B51861CA76E9CF36125166D6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_51AED58FB8643E877D67CF361251DA1B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EED8ECA6B51861CA76E9CF36125166D6" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_51AED58FB8643E877D67CF361251DA1B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_730D79A34A87DBDFB978CF361252FA0D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_89FFBABBEF1868444E67CF3612524F1F" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_730D79A34A87DBDFB978CF361252FA0D" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedStatementsOfIncome" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_8E4373E3669FD00761BFC12C7FEB81BE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_StatementTable_8E4373E3669FD00761BFC12C7FEB81BE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_225C017E5AE24D526200C12C7FEC84B5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_8E4373E3669FD00761BFC12C7FEB81BE" xlink:to="loc_srt_ProductOrServiceAxis_225C017E5AE24D526200C12C7FEC84B5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_225C017E5AE24D526200C12C7FEC84B5" xlink:to="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_225C017E5AE24D526200C12C7FEC84B5" xlink:to="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_HealthCareCapitationRevenueMember" xlink:label="loc_ameh_HealthCareCapitationRevenueMember_0ABCA6A0E5FD35E2B565C12C7FECE503" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:to="loc_ameh_HealthCareCapitationRevenueMember_0ABCA6A0E5FD35E2B565C12C7FECE503" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_HealthCareOtherMember" xlink:label="loc_us-gaap_HealthCareOtherMember_85BD9EC16BE57F0C9EC9C12C7FED2E2A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:to="loc_us-gaap_HealthCareOtherMember_85BD9EC16BE57F0C9EC9C12C7FED2E2A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ManagementServiceMember" xlink:label="loc_us-gaap_ManagementServiceMember_93E03F728D59D95F303FC12C7FED9E50" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:to="loc_us-gaap_ManagementServiceMember_93E03F728D59D95F303FC12C7FED9E50" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_HealthCarePatientServiceMember" xlink:label="loc_us-gaap_HealthCarePatientServiceMember_8E73F49A6232BC37B35CC12C7FED3B22" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:to="loc_us-gaap_HealthCarePatientServiceMember_8E73F49A6232BC37B35CC12C7FED3B22" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductAndServiceOtherMember" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_31A84BC6823C4959472EC12C7FED7DA1" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2040864D93D646B9CD3DC12C7FEC3956" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_31A84BC6823C4959472EC12C7FED7DA1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_319C9788F74089E03ACAC12C7FEE054D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_RevenuesAbstract_319C9788F74089E03ACAC12C7FEE054D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3D74534E103516356EFEC12C7FEEA86D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_319C9788F74089E03ACAC12C7FEE054D" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3D74534E103516356EFEC12C7FEEA86D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingExpensesAbstract" xlink:label="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_26D525D5BB669E291682C12C7FEED799" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_26D525D5BB669E291682C12C7FEED799" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_C163F40E591CB569AC53C12C7FEE269C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_C163F40E591CB569AC53C12C7FEE269C" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts" xlink:label="loc_ameh_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts_825AB5E0BE7E40A29E70C12C7FEFB568" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_ameh_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts_825AB5E0BE7E40A29E70C12C7FEFB568" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_44EF87FCF53C39CAA3A6C12C7FEFD302" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_44EF87FCF53C39CAA3A6C12C7FEFD302" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_647D401C33ECB8D20932C12C7FEF7BAC" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_647D401C33ECB8D20932C12C7FEF7BAC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_BFE1E5B9C16E7DEAC740C12C7FEF60C8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5F0DEC0EEA19E483E8F5C12C7FEE025C" xlink:to="loc_us-gaap_OperatingExpenses_BFE1E5B9C16E7DEAC740C12C7FEF60C8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_1A2832395CE1FE9812C8C12C7FEFF4D2" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_OperatingIncomeLoss_1A2832395CE1FE9812C8C12C7FEFF4D2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_DAF59A0DD0FE79D2D06EC12C7FF08F53" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_DAF59A0DD0FE79D2D06EC12C7FF08F53" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_CDBF6ACB78F5FEDA03E3C12C7FF05ECA" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_InterestExpense_CDBF6ACB78F5FEDA03E3C12C7FF05ECA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_CF4739670FAC72557AC6C12C7FF0EC01" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_InvestmentIncomeInterest_CF4739670FAC72557AC6C12C7FF0EC01" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9B08E698840F514A527BC12C7FF00D34" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9B08E698840F514A527BC12C7FF00D34" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfNotesReceivable" xlink:label="loc_us-gaap_GainLossOnSaleOfNotesReceivable_21575C4461E607B4FDD1C12C7FF064D7" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_GainLossOnSaleOfNotesReceivable_21575C4461E607B4FDD1C12C7FF064D7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_FFDB04D5E4333C03FC45C12C7FF0718E" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_GainLossOnInvestments_FFDB04D5E4333C03FC45C12C7FF0718E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_C2004D765D83EE5418EDC12C7FF11501" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_C2004D765D83EE5418EDC12C7FF11501" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_4E1CD73A398BD239719FC12C7FF1F108" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_AA99DA63515FC71DB67CC12C7FEFDC9C" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_4E1CD73A398BD239719FC12C7FF1F108" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_413DCD57E0BB77DBAD32C12C7FF12A22" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_413DCD57E0BB77DBAD32C12C7FF12A22" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_955C6AA782023F7AAA15C12C7FF1010B" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_955C6AA782023F7AAA15C12C7FF1010B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_EEDD25B27C0503D7CA86C12C7FF1FDAE" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_ProfitLoss_EEDD25B27C0503D7CA86C12C7FF1FDAE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_83EA879D2810669CBD3FC12C7FF2E590" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_83EA879D2810669CBD3FC12C7FF2E590" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_C7C3C9A396567F6191A3C12C7FF26F13" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_NetIncomeLoss_C7C3C9A396567F6191A3C12C7FF26F13" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_F136ED562D1D1A808151C12C7FF20468" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_EarningsPerShareBasic_F136ED562D1D1A808151C12C7FF20468" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_66323CD3FCA03B53FBF6C12C7FF245D7" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_EarningsPerShareDiluted_66323CD3FCA03B53FBF6C12C7FF245D7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_BD7523CA8EFB821A1A05C12C7FF2B4A2" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_BD7523CA8EFB821A1A05C12C7FF2B4A2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7C3466C352EE5D7D41E2C12C7FF2457D" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_535763ED6182A6385D1AC12C7FED6022" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7C3466C352EE5D7D41E2C12C7FF2457D" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedStatementsOfMezzanineAndShareholdersEquity" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_99485F3F7FD5C6A4EADCCFDA3E658B66" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_99485F3F7FD5C6A4EADCCFDA3E658B66" xlink:to="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_C42DB20F451B3687FB88CFDA3E61E480" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:to="loc_dei_LegalEntityAxis_C42DB20F451B3687FB88CFDA3E61E480" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_B0F5F6A598FC72E87291CFDA3E6200DA_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_C42DB20F451B3687FB88CFDA3E61E480" xlink:to="loc_dei_EntityDomain_B0F5F6A598FC72E87291CFDA3E6200DA_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_B0F5F6A598FC72E87291CFDA3E6200DA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_C42DB20F451B3687FB88CFDA3E61E480" xlink:to="loc_dei_EntityDomain_B0F5F6A598FC72E87291CFDA3E6200DA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MezzanineMember" xlink:label="loc_ameh_MezzanineMember_F9007CF12402824D0C86CFDA3E6202B5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_B0F5F6A598FC72E87291CFDA3E6200DA" xlink:to="loc_ameh_MezzanineMember_F9007CF12402824D0C86CFDA3E6202B5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_E3D66FB2CA8BA4BC197FCFDA3E62E28B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_E3D66FB2CA8BA4BC197FCFDA3E62E28B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_E3D66FB2CA8BA4BC197FCFDA3E62E28B" xlink:to="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_E3D66FB2CA8BA4BC197FCFDA3E62E28B" xlink:to="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_26E6902BECCDA854C1FACFDA3E63547F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:to="loc_us-gaap_CommonStockMember_26E6902BECCDA854C1FACFDA3E63547F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_C3C4D518583B7B52AE01CFDA3E637937" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_C3C4D518583B7B52AE01CFDA3E637937" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_089B896A4CC88A87637BCFDA3E633DCE" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:to="loc_us-gaap_RetainedEarningsMember_089B896A4CC88A87637BCFDA3E633DCE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_D691E50556C8847DCD84CFDA3E639BFD" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D43C0E4B3D1CA8A21E4ACFDA3E6256E5" xlink:to="loc_us-gaap_NoncontrollingInterestMember_D691E50556C8847DCD84CFDA3E639BFD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7309D3753B11F7592300CFDA3E632C51" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:to="loc_srt_CounterpartyNameAxis_7309D3753B11F7592300CFDA3E632C51" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2A26A981F86A5665E85BCFDA3E63E1FD_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7309D3753B11F7592300CFDA3E632C51" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2A26A981F86A5665E85BCFDA3E63E1FD_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2A26A981F86A5665E85BCFDA3E63E1FD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7309D3753B11F7592300CFDA3E632C51" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2A26A981F86A5665E85BCFDA3E63E1FD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_635C1E7A58FCFA955CC2CFDA3E64C529" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2A26A981F86A5665E85BCFDA3E63E1FD" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_635C1E7A58FCFA955CC2CFDA3E64C529" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_01597779038AEEB03517CFDA3E64479C" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A7D71E079D13F50C61A5CFDA3E6136CC" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_01597779038AEEB03517CFDA3E64479C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_23F4DA5148FBB0E36C06CFDA3E64D778_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_01597779038AEEB03517CFDA3E64479C" xlink:to="loc_us-gaap_RelatedPartyDomain_23F4DA5148FBB0E36C06CFDA3E64D778_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_23F4DA5148FBB0E36C06CFDA3E64D778" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_01597779038AEEB03517CFDA3E64479C" xlink:to="loc_us-gaap_RelatedPartyDomain_23F4DA5148FBB0E36C06CFDA3E64D778" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_1FCA4058067064C3ECD2CFDA3E653C67" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_23F4DA5148FBB0E36C06CFDA3E64D778" xlink:to="loc_srt_AffiliatedEntityMember_1FCA4058067064C3ECD2CFDA3E653C67" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_99485F3F7FD5C6A4EADCCFDA3E658B66" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_39038C640A1D22368906CFDA3E65CED8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_39038C640A1D22368906CFDA3E65CED8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_C2B574267515CA6E19EFCFDA3E65E968" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_SharesOutstanding_C2B574267515CA6E19EFCFDA3E65E968" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_7BF2AA68E11FF4D63D37CFDA3E666653" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_7BF2AA68E11FF4D63D37CFDA3E666653" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetIncomeLossIncludingPortionAttributableToNoncontrollingInterestAndTemporaryEquity" xlink:label="loc_ameh_NetIncomeLossIncludingPortionAttributableToNoncontrollingInterestAndTemporaryEquity_505CA3729179621AB773CFDA3E667A39" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_NetIncomeLossIncludingPortionAttributableToNoncontrollingInterestAndTemporaryEquity_505CA3729179621AB773CFDA3E667A39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_CDFF0E89CEEB5BB058BCCFDA3E66E198" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_CDFF0E89CEEB5BB058BCCFDA3E66E198" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_20261F6662FD5545A7CFCFDA3E6602CF" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_20261F6662FD5545A7CFCFDA3E6602CF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FE476839DBB4C014C801CFDA3E66F66A" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FE476839DBB4C014C801CFDA3E66F66A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_05971B797359FA772A5ECFDA3E6658D2" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_05971B797359FA772A5ECFDA3E6658D2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AdjustmentsToAdditionalPaidInCapitalMergerPurchasePriceAdjustment" xlink:label="loc_ameh_AdjustmentsToAdditionalPaidInCapitalMergerPurchasePriceAdjustment_0D7BC077C7ACE417A40ACFDA3E67B849" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_AdjustmentsToAdditionalPaidInCapitalMergerPurchasePriceAdjustment_0D7BC077C7ACE417A40ACFDA3E67B849" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredParValueMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredParValueMethod_8C63B3E93C67368C7BB3CFDA3E67C795" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredParValueMethod_8C63B3E93C67368C7BB3CFDA3E67C795" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_24E04481D8E179E89AEFCFDA3E671044" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_24E04481D8E179E89AEFCFDA3E671044" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringThePeriodValueOfExerciseOfOptionAndWarrants" xlink:label="loc_ameh_StockIssuedDuringThePeriodValueOfExerciseOfOptionAndWarrants_2C4DACD993B4C1C7BEA4CFDA3E671E84" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringThePeriodValueOfExerciseOfOptionAndWarrants_2C4DACD993B4C1C7BEA4CFDA3E671E84" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringThePeriodSharesOfExerciseOfOptionAndWarrants" xlink:label="loc_ameh_StockIssuedDuringThePeriodSharesOfExerciseOfOptionAndWarrants_3C17AB0D9650AA422E8BCFDA3E67E1F4" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringThePeriodSharesOfExerciseOfOptionAndWarrants_3C17AB0D9650AA422E8BCFDA3E67E1F4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_C5B6A28216D667590022CFDA3E67AA0C" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_C5B6A28216D667590022CFDA3E67AA0C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_B1C12434F880EB4CC4EBCFDA3E68C0AF" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_B1C12434F880EB4CC4EBCFDA3E68C0AF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentOfWarrantsGrantedForServices" xlink:label="loc_us-gaap_AdjustmentOfWarrantsGrantedForServices_EE9FEDD4CD0E3492B5E5CFDA3E68463A" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_AdjustmentOfWarrantsGrantedForServices_EE9FEDD4CD0E3492B5E5CFDA3E68463A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NoncontrollingInterestIncreaseFromCapitalCharge" xlink:label="loc_ameh_NoncontrollingInterestIncreaseFromCapitalCharge_60781906496855C5A38BCFDA3E68935E" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_NoncontrollingInterestIncreaseFromCapitalCharge_60781906496855C5A38BCFDA3E68935E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_D9F6E337158E50A8427ECFDA3E688385" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_D9F6E337158E50A8427ECFDA3E688385" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_FAC75B1C5B65685D1786CFDA3E68F9DB" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_FAC75B1C5B65685D1786CFDA3E68F9DB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_7252B786BD93F1FF89CFCFDA3E687583" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_7252B786BD93F1FF89CFCFDA3E687583" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_778959B009097056B990CFDA3E68B3D4" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_778959B009097056B990CFDA3E68B3D4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MinorityInterestDecreaseFromRedemptions" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromRedemptions_41B4A8B2142006BCF3E8CFDA3E69DB02" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromRedemptions_41B4A8B2142006BCF3E8CFDA3E69DB02" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodValueConversionOfLiabilityToEquity" xlink:label="loc_ameh_StockIssuedDuringPeriodValueConversionOfLiabilityToEquity_3535862A52C19F763148CFDA3E69D5E7" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringPeriodValueConversionOfLiabilityToEquity_3535862A52C19F763148CFDA3E69D5E7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodSharesConversionOfLiabilityToEquity" xlink:label="loc_ameh_StockIssuedDuringPeriodSharesConversionOfLiabilityToEquity_DCB30A39041656FD0CBCCFDA3E69934B" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringPeriodSharesConversionOfLiabilityToEquity_DCB30A39041656FD0CBCCFDA3E69934B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodValueMerger" xlink:label="loc_ameh_StockIssuedDuringPeriodValueMerger_81CBD3A6D14C3339B43BCFDA3E69CA01" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringPeriodValueMerger_81CBD3A6D14C3339B43BCFDA3E69CA01" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodSharesMerger" xlink:label="loc_ameh_StockIssuedDuringPeriodSharesMerger_2B5D2E461FC474B451CBCFDA3E694F42" xlink:type="locator"/>

<link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringPeriodSharesMerger_2B5D2E461FC474B451CBCFDA3E694F42" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_FAC7F645EF818BC24237CFDA3E69ABEF" xlink:type="locator"/>

<link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_FAC7F645EF818BC24237CFDA3E69ABEF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_78A6452955D780F318C6CFDA3E6A6F8A" xlink:type="locator"/>

<link:definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_78A6452955D780F318C6CFDA3E6A6F8A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodValueStockOptionsLiabilityReclassifiedToEquity" xlink:label="loc_ameh_StockIssuedDuringPeriodValueStockOptionsLiabilityReclassifiedToEquity_C01DDFC2F4CB0A467660CFDA3E6A50C2" xlink:type="locator"/>

<link:definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockIssuedDuringPeriodValueStockOptionsLiabilityReclassifiedToEquity_C01DDFC2F4CB0A467660CFDA3E6A50C2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockRepurchaseDuringPeriodValueReleaseOfHoldBackShares" xlink:label="loc_ameh_StockRepurchaseDuringPeriodValueReleaseOfHoldBackShares_A87A8A5F83545448269CCFDA3E6AB6F6" xlink:type="locator"/>

<link:definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockRepurchaseDuringPeriodValueReleaseOfHoldBackShares_A87A8A5F83545448269CCFDA3E6AB6F6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockRepurchaseDuringPeriodSharesReleaseOfHoldBackShares" xlink:label="loc_ameh_StockRepurchaseDuringPeriodSharesReleaseOfHoldBackShares_9E7313FB437653E8A194CFDA3E6AF422" xlink:type="locator"/>

<link:definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_05F02624448C40F046FACFDA3E65CD69" xlink:to="loc_ameh_StockRepurchaseDuringPeriodSharesReleaseOfHoldBackShares_9E7313FB437653E8A194CFDA3E6AF422" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/ConsolidatedStatementsOfMezzanineAndShareholdersEquityParenthetical" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_A5C13DF1FC8778992665C1379702D40E" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_E3A05C2E6D1A3F89D13FC13797011E9C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_A5C13DF1FC8778992665C1379702D40E" xlink:to="loc_us-gaap_StatementTable_E3A05C2E6D1A3F89D13FC13797011E9C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_DE00C0AA93465D09FF4BC1379701EFE5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_E3A05C2E6D1A3F89D13FC13797011E9C" xlink:to="loc_us-gaap_StatementClassOfStockAxis_DE00C0AA93465D09FF4BC1379701EFE5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_71C07A74970A0DE32B5EC13797022F67_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DE00C0AA93465D09FF4BC1379701EFE5" xlink:to="loc_us-gaap_ClassOfStockDomain_71C07A74970A0DE32B5EC13797022F67_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_71C07A74970A0DE32B5EC13797022F67" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DE00C0AA93465D09FF4BC1379701EFE5" xlink:to="loc_us-gaap_ClassOfStockDomain_71C07A74970A0DE32B5EC13797022F67" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_HoldbackSharesMember" xlink:label="loc_ameh_HoldbackSharesMember_A6EEF269FD4BECC2D546C13797021707" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_71C07A74970A0DE32B5EC13797022F67" xlink:to="loc_ameh_HoldbackSharesMember_A6EEF269FD4BECC2D546C13797021707" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_F107F98B9E8594DB8DD2C137970237F9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_A5C13DF1FC8778992665C1379702D40E" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_F107F98B9E8594DB8DD2C137970237F9" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedParty" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyAdditionalInformationDetail" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_E17257242BC8CF5D0712C12C7DEC336E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_DebtInstrumentAxis_E17257242BC8CF5D0712C12C7DEC336E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_E17257242BC8CF5D0712C12C7DEC336E" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_E17257242BC8CF5D0712C12C7DEC336E" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CreditAgreementMember" xlink:label="loc_ameh_CreditAgreementMember_137787ABC40A3F5D0192C12C7DEDDCDA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:to="loc_ameh_CreditAgreementMember_137787ABC40A3F5D0192C12C7DEDDCDA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NMMLineOfCreditAgreementMember" xlink:label="loc_ameh_NMMLineOfCreditAgreementMember_941CE2635478318832D8C12C7DEDC0FF" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:to="loc_ameh_NMMLineOfCreditAgreementMember_941CE2635478318832D8C12C7DEDC0FF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BankLoanMember" xlink:label="loc_ameh_BankLoanMember_96D355B8785988978ED0C12C7DED2397" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:to="loc_ameh_BankLoanMember_96D355B8785988978ED0C12C7DED2397" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NmmBusinessLoanAgreementMember" xlink:label="loc_ameh_NmmBusinessLoanAgreementMember_E0BB5F703F505278622AC12C7DEE1F47" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:to="loc_ameh_NmmBusinessLoanAgreementMember_E0BB5F703F505278622AC12C7DEE1F47" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcBusinessLoanAgreementMember" xlink:label="loc_ameh_ApcBusinessLoanAgreementMember_8425DF620C0DAF44A293C12C7DEEFE2B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_BE421577995D44C5DE80C12C7DEC6D93" xlink:to="loc_ameh_ApcBusinessLoanAgreementMember_8425DF620C0DAF44A293C12C7DEEFE2B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_9BCA5916836E3DEEE0DFC12C7DEE7CCE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_CreditFacilityAxis_9BCA5916836E3DEEE0DFC12C7DEE7CCE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_9BCA5916836E3DEEE0DFC12C7DEE7CCE" xlink:to="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_9BCA5916836E3DEEE0DFC12C7DEE7CCE" xlink:to="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_9B5D75390E36194D05A5C12C7DEE1A44" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_9B5D75390E36194D05A5C12C7DEE1A44" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LetterOfCreditMember" xlink:label="loc_us-gaap_LetterOfCreditMember_8B9B18F45B67F54CF4C7C12C7DEEF876" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:to="loc_us-gaap_LetterOfCreditMember_8B9B18F45B67F54CF4C7C12C7DEEF876" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_TermLoanAMember" xlink:label="loc_ameh_TermLoanAMember_41E3824F5643BA4A91CDC12C7DEFE797" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:to="loc_ameh_TermLoanAMember_41E3824F5643BA4A91CDC12C7DEFE797" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StandbyLettersOfCreditMember" xlink:label="loc_us-gaap_StandbyLettersOfCreditMember_52F4FE835CBB81EB1044C12C7DEF136D" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:to="loc_us-gaap_StandbyLettersOfCreditMember_52F4FE835CBB81EB1044C12C7DEF136D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_CE905458105CE80EF41DC12C7DEFD520" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_3FB82961D0B7A2946FFDC12C7DEE835B" xlink:to="loc_us-gaap_LineOfCreditMember_CE905458105CE80EF41DC12C7DEFD520" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_477C3F4493875E425464C12C7DEF7EBE" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_477C3F4493875E425464C12C7DEF7EBE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_69F4B7067B9284BFE018C12C7DEF218D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_477C3F4493875E425464C12C7DEF7EBE" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_69F4B7067B9284BFE018C12C7DEF218D_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_477C3F4493875E425464C12C7DEF7EBE" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_69F4B7067B9284BFE018C12C7DEF218D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_798F221E2F3E2B8A6C85C12C7DF03738" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_69F4B7067B9284BFE018C12C7DEF218D" xlink:to="loc_us-gaap_LineOfCreditMember_798F221E2F3E2B8A6C85C12C7DF03738" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_F5E890E9754EAA8486F6C12C7DF0729E" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_F5E890E9754EAA8486F6C12C7DF0729E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_F5E890E9754EAA8486F6C12C7DF0729E" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_F5E890E9754EAA8486F6C12C7DF0729E" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentPeriodOneMember" xlink:label="loc_ameh_PaymentPeriodOneMember_F91AB0A23BFC99BF6960C12C7DF05D90" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5" xlink:to="loc_ameh_PaymentPeriodOneMember_F91AB0A23BFC99BF6960C12C7DF05D90" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentPeriodTwoMember" xlink:label="loc_ameh_PaymentPeriodTwoMember_014E26800FBF8926DFCAC12C7DF0716A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5" xlink:to="loc_ameh_PaymentPeriodTwoMember_014E26800FBF8926DFCAC12C7DF0716A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentPeriodThreeMember" xlink:label="loc_ameh_PaymentPeriodThreeMember_FB45099A9AD43B13A49DC12C7DF107AB" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_2BF4065CC6CE2FEB2809C12C7DF0C8A5" xlink:to="loc_ameh_PaymentPeriodThreeMember_FB45099A9AD43B13A49DC12C7DF107AB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_9D7788D3077CA4BE24DAC12C7DF173F3" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_srt_CounterpartyNameAxis_9D7788D3077CA4BE24DAC12C7DF173F3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D4C54148ED575CC222D3C12C7DF110D9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_9D7788D3077CA4BE24DAC12C7DF173F3" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D4C54148ED575CC222D3C12C7DF110D9_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D4C54148ED575CC222D3C12C7DF110D9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_9D7788D3077CA4BE24DAC12C7DF173F3" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D4C54148ED575CC222D3C12C7DF110D9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APAMHMedicalCorporationMember" xlink:label="loc_ameh_APAMHMedicalCorporationMember_D52675363ED2402DB52FC12C7DF6A525" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D4C54148ED575CC222D3C12C7DF110D9" xlink:to="loc_ameh_APAMHMedicalCorporationMember_D52675363ED2402DB52FC12C7DF6A525" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A399DB4F47D510F54F0BC12C7DF73DDB" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A399DB4F47D510F54F0BC12C7DF73DDB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_93CCEC943A2D80177E8FC12C7DF767E0_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A399DB4F47D510F54F0BC12C7DF73DDB" xlink:to="loc_us-gaap_RelatedPartyDomain_93CCEC943A2D80177E8FC12C7DF767E0_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_93CCEC943A2D80177E8FC12C7DF767E0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_A399DB4F47D510F54F0BC12C7DF73DDB" xlink:to="loc_us-gaap_RelatedPartyDomain_93CCEC943A2D80177E8FC12C7DF767E0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_9DE722BC70030465F289C12C7DF78F28" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_93CCEC943A2D80177E8FC12C7DF767E0" xlink:to="loc_srt_AffiliatedEntityMember_9DE722BC70030465F289C12C7DF78F28" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_AA91B28F2E1045ADFD27C12C7DF7E6D1" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_srt_RangeAxis_AA91B28F2E1045ADFD27C12C7DF7E6D1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_AA91B28F2E1045ADFD27C12C7DF7E6D1" xlink:to="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_AA91B28F2E1045ADFD27C12C7DF7E6D1" xlink:to="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_7F1B23A2F9417DB08B25C12C7DF818E0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0" xlink:to="loc_srt_MinimumMember_7F1B23A2F9417DB08B25C12C7DF818E0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_C0A0E87F03415F4B7C62C12C7DF8B5C6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_C84F7ED1DA18F03FCA5CC12C7DF79CE0" xlink:to="loc_srt_MaximumMember_C0A0E87F03415F4B7C62C12C7DF8B5C6" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_69920B2A214450F1D5D0C12C7DF8EDE5" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_dei_LegalEntityAxis_69920B2A214450F1D5D0C12C7DF8EDE5" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_69920B2A214450F1D5D0C12C7DF8EDE5" xlink:to="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_69920B2A214450F1D5D0C12C7DF8EDE5" xlink:to="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementMember" xlink:label="loc_ameh_NetworkMedicalManagementMember_77CEB51C45C66768C19FC12C7DF903A0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:to="loc_ameh_NetworkMedicalManagementMember_77CEB51C45C66768C19FC12C7DF903A0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IccMember" xlink:label="loc_ameh_IccMember_A68C37FF33C0F089F08DC12C7DF9652E" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:to="loc_ameh_IccMember_A68C37FF33C0F089F08DC12C7DF9652E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcMember" xlink:label="loc_ameh_ApcMember_1856FD135A91B238DFC1C12C7DF93471" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:to="loc_ameh_ApcMember_1856FD135A91B238DFC1C12C7DF93471" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApaacoMember" xlink:label="loc_ameh_ApaacoMember_C69814982A0BE7099671C12C7DF917AA" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:to="loc_ameh_ApaacoMember_C69814982A0BE7099671C12C7DF917AA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_A2613641E822002C95EBC12C7DF94EF1" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_EF035F3830FFA4269535C12C7DF825FA" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_A2613641E822002C95EBC12C7DF94EF1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_8DD3B5E5C8BE05473A5BC12C7DFAD458" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_VariableRateAxis_8DD3B5E5C8BE05473A5BC12C7DFAD458" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_B5860BA7363938FAD337C12C7DFA422D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_8DD3B5E5C8BE05473A5BC12C7DFAD458" xlink:to="loc_us-gaap_VariableRateDomain_B5860BA7363938FAD337C12C7DFA422D_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_8DD3B5E5C8BE05473A5BC12C7DFAD458" xlink:to="loc_us-gaap_VariableRateDomain_B5860BA7363938FAD337C12C7DFA422D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_51A6B0F4FC792930CD94C12C7DFA4490" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_B5860BA7363938FAD337C12C7DFA422D" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_51A6B0F4FC792930CD94C12C7DFA4490" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrimeRateMember" xlink:label="loc_us-gaap_PrimeRateMember_EA2F662A4F6CCECCBD36C12C7DFA3389" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_B5860BA7363938FAD337C12C7DFA422D" xlink:to="loc_us-gaap_PrimeRateMember_EA2F662A4F6CCECCBD36C12C7DFA3389" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_D782AEA13FB01AD17D1DC12C7DFB2934" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_016F4188346CB0EFE9F5C12C7DEC5591" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_D782AEA13FB01AD17D1DC12C7DFB2934" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_5E4731E97FD5ED64DB15C12C7DFB86A5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_D782AEA13FB01AD17D1DC12C7DFB2934" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_5E4731E97FD5ED64DB15C12C7DFB86A5_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_D782AEA13FB01AD17D1DC12C7DFB2934" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_5E4731E97FD5ED64DB15C12C7DFB86A5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PreferredBankMember" xlink:label="loc_ameh_PreferredBankMember_F9FBF357F7E7B1985FE4C12C7DFB556E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_5E4731E97FD5ED64DB15C12C7DFB86A5" xlink:to="loc_ameh_PreferredBankMember_F9FBF357F7E7B1985FE4C12C7DFB556E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTerm" xlink:label="loc_us-gaap_DebtInstrumentTerm_D0816BD728ECAD2237B0C12C7DFBCE8B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentTerm_D0816BD728ECAD2237B0C12C7DFBCE8B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_0414AE8F84DF36618406C12C7DFC0EBC" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_0414AE8F84DF36618406C12C7DFC0EBC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_336E61E207C5BEA708DBC12C7DFC4255" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_336E61E207C5BEA708DBC12C7DFC4255" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_AF6FB7E630F3213246A6C12C7DFC4B08" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_AF6FB7E630F3213246A6C12C7DFC4B08" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal" xlink:label="loc_us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal_8CEF67A4A0FDDB335592C12C7DFCDDA6" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal_8CEF67A4A0FDDB335592C12C7DFCDDA6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableNet" xlink:label="loc_us-gaap_NotesReceivableNet_BA9733BE7FCAC2A5E835C12C7DFC1C9A" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_NotesReceivableNet_BA9733BE7FCAC2A5E835C12C7DFC1C9A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_61E92C7381C31BC35931C12C7DFC456E" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_61E92C7381C31BC35931C12C7DFC456E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_9096DB95CD8C74CDE7AAC12C7DFD9FED" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_9096DB95CD8C74CDE7AAC12C7DFD9FED" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_F0525357831B572D8C72C12C7DFD15CF" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_F0525357831B572D8C72C12C7DFD15CF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentCovenantLeverageRatioMaximum" xlink:label="loc_ameh_DebtInstrumentCovenantLeverageRatioMaximum_AD4066A8ADD89C0B76E7C12C7DFDC660" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentCovenantLeverageRatioMaximum_AD4066A8ADD89C0B76E7C12C7DFDC660" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentCovenantLeverageRatioIncrementalChange" xlink:label="loc_ameh_DebtInstrumentCovenantLeverageRatioIncrementalChange_4790A0A51863487E7635C12C7DFD86EF" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentCovenantLeverageRatioIncrementalChange_4790A0A51863487E7635C12C7DFD86EF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentCovenantLeverageRatioMinimum" xlink:label="loc_ameh_DebtInstrumentCovenantLeverageRatioMinimum_08D57BBB3BAE84B2B20DC12C7DFDF0BC" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentCovenantLeverageRatioMinimum_08D57BBB3BAE84B2B20DC12C7DFDF0BC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentCovenantInterestCoverageRatioMinimum" xlink:label="loc_ameh_DebtInstrumentCovenantInterestCoverageRatioMinimum_B09E31AAED328AEC9C6FC12C7DFD0A5A" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentCovenantInterestCoverageRatioMinimum_B09E31AAED328AEC9C6FC12C7DFD0A5A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDefaultLongtermDebtAmount" xlink:label="loc_us-gaap_DebtDefaultLongtermDebtAmount_436B8F8F2C768C3376A6C12C7DFEA24D" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtDefaultLongtermDebtAmount_436B8F8F2C768C3376A6C12C7DFEA24D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentApprovalThresholdOfShareholdersForUseOfFundsPercentage" xlink:label="loc_ameh_DebtInstrumentApprovalThresholdOfShareholdersForUseOfFundsPercentage_3099FA049FC006F9AE47C12C7DFE9291" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentApprovalThresholdOfShareholdersForUseOfFundsPercentage_3099FA049FC006F9AE47C12C7DFE9291" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DebtInstrumentApprovedThresholdUseOfFunds" xlink:label="loc_ameh_DebtInstrumentApprovedThresholdUseOfFunds_97E12D12066787F52373C12C7DFE2BC8" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_DebtInstrumentApprovedThresholdUseOfFunds_97E12D12066787F52373C12C7DFE2BC8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet" xlink:label="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_F307C1C3F720DE0334A7C12C7DFEBD6D" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_F307C1C3F720DE0334A7C12C7DFEBD6D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_C780E5C18F7D7A022DFCC12C7DFE941B" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_C780E5C18F7D7A022DFCC12C7DFE941B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_C6D841F8A288AD4338F6C12C7DFE1492" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_C6D841F8A288AD4338F6C12C7DFE1492" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_6A6A6FFCB758E0582F02C12C7DFF4E8D" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_6A6A6FFCB758E0582F02C12C7DFF4E8D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_75E6BB7373686EF6EE71C12C7DFF83FA" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_75E6BB7373686EF6EE71C12C7DFF83FA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_77F8571B986EB22589DAC12C7DFF9701" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCredit_77F8571B986EB22589DAC12C7DFF9701" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LineOfCreditFacilityGuaranteeGivenByRelatedParties" xlink:label="loc_ameh_LineOfCreditFacilityGuaranteeGivenByRelatedParties_2F43C5B57598900212EEC12C7DFFDF5D" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_LineOfCreditFacilityGuaranteeGivenByRelatedParties_2F43C5B57598900212EEC12C7DFFDF5D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityExpirationPeriod" xlink:label="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_D17A63FE19BC59F46D36C12C7DFF5794" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_D17A63FE19BC59F46D36C12C7DFF5794" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LineOfCreditFacilityExpirationPeriodPeriodOfNotification" xlink:label="loc_ameh_LineOfCreditFacilityExpirationPeriodPeriodOfNotification_A04CF5C36AEA8E6573B3C12C7DFFB917" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8DF5A8B07E33AB7A98A2C12C7DFBAA7A" xlink:to="loc_ameh_LineOfCreditFacilityExpirationPeriodPeriodOfNotification_A04CF5C36AEA8E6573B3C12C7DFFB917" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfCreditFacilityInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_D1B1D79BC11FB66B2D63C1379584445A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_D1B1D79BC11FB66B2D63C1379584445A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_D586AD0FA0586443E850C1379584F8C5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_D1B1D79BC11FB66B2D63C1379584445A" xlink:to="loc_us-gaap_CreditFacilityAxis_D586AD0FA0586443E850C1379584F8C5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_D586AD0FA0586443E850C1379584F8C5" xlink:to="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_D586AD0FA0586443E850C1379584F8C5" xlink:to="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_TermLoanAMember" xlink:label="loc_ameh_TermLoanAMember_B0A23B837BE8FB5AFAC0C13795853566" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03" xlink:to="loc_ameh_TermLoanAMember_B0A23B837BE8FB5AFAC0C13795853566" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_E252992F93F77A2F5CEAC13795852FBD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_25A96BA8E4B5B4116E1CC1379585AC03" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_E252992F93F77A2F5CEAC13795852FBD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_0CA0363DF56E09EE3ACDC1379586BF11" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:to="loc_us-gaap_LineOfCredit_0CA0363DF56E09EE3ACDC1379586BF11" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LinesOfCreditCurrent" xlink:label="loc_us-gaap_LinesOfCreditCurrent_EEB7D9843DE91544EC96C13795862A93" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:to="loc_us-gaap_LinesOfCreditCurrent_EEB7D9843DE91544EC96C13795862A93" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_C96B8543643ADB0DD3D4C137958642D9" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_C96B8543643ADB0DD3D4C137958642D9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_EBE5B6265499D27CA90FC1379586CDA8" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_CBC9748BDEFF8FE093D8C13795853A9C" xlink:to="loc_us-gaap_LongTermDebt_EBE5B6265499D27CA90FC1379586CDA8" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyScheduleOfMaturitiesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/CreditFacilityBankLoanAndLinesOfCreditRelatedPartyTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/DescriptionOfBusiness" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/DescriptionOfBusinessAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="ameh-20191231.xsd#ameh_DescriptionOfBusinessLineItems" xlink:label="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:type="locator"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DescriptionOfBusinessTable" xlink:label="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_D7BAE5ADA48C2C983CA2C13796B463DA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_dei_LegalEntityAxis_D7BAE5ADA48C2C983CA2C13796B463DA" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_D7BAE5ADA48C2C983CA2C13796B463DA" xlink:to="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_D7BAE5ADA48C2C983CA2C13796B463DA" xlink:to="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_DC8959213736D9891ABEC13796B5A688" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_DC8959213736D9891ABEC13796B5A688" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcLsmaMember" xlink:label="loc_ameh_ApcLsmaMember_9DBFC2D983801B39BE24C13796B5073F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:to="loc_ameh_ApcLsmaMember_9DBFC2D983801B39BE24C13796B5073F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_D7CD5AA4BDFBC78AD853C13796B52C0F" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:to="loc_ameh_AccountableHealthCareIPAMember_D7CD5AA4BDFBC78AD853C13796B52C0F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AmgIncMember" xlink:label="loc_ameh_AmgIncMember_1818572A41B650E8EEDDC13796B5DBE4" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:to="loc_ameh_AmgIncMember_1818572A41B650E8EEDDC13796B5DBE4" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_4EC134D527610A8FD283C13796B61873" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_7A081BF7C564233EBBF3C13796B52A6A" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_4EC134D527610A8FD283C13796B61873" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4E441325C4332F43501AC13796B623C6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4E441325C4332F43501AC13796B623C6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_C2E8872048251F2FF8E2C13796B60591_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4E441325C4332F43501AC13796B623C6" xlink:to="loc_us-gaap_RelatedPartyDomain_C2E8872048251F2FF8E2C13796B60591_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_C2E8872048251F2FF8E2C13796B60591" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4E441325C4332F43501AC13796B623C6" xlink:to="loc_us-gaap_RelatedPartyDomain_C2E8872048251F2FF8E2C13796B60591" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_F3149DF0CF16370D7343C13796B69C95" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_C2E8872048251F2FF8E2C13796B60591" xlink:to="loc_srt_AffiliatedEntityMember_F3149DF0CF16370D7343C13796B69C95" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7D387CDD66DBA0F1DDA9C13796B7C0B0" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_srt_CounterpartyNameAxis_7D387CDD66DBA0F1DDA9C13796B7C0B0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7D387CDD66DBA0F1DDA9C13796B7C0B0" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7D387CDD66DBA0F1DDA9C13796B7C0B0" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APAMHMedicalCorporationMember" xlink:label="loc_ameh_APAMHMedicalCorporationMember_1B9A6D4C139E31DA90B1C13796B7856B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6" xlink:to="loc_ameh_APAMHMedicalCorporationMember_1B9A6D4C139E31DA90B1C13796B7856B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_59B62C5E9CCFB90C8D74C13796B755D7" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_59B62C5E9CCFB90C8D74C13796B755D7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.JayMember" xlink:label="loc_ameh_Dr.JayMember_7643EEA83AB807469025C13796B7D823" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_FFF741E9196AB68F8BD0C13796B78EB6" xlink:to="loc_ameh_Dr.JayMember_7643EEA83AB807469025C13796B7D823" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_4249E7D479620AE62316C13796B89F78" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_us-gaap_StatementClassOfStockAxis_4249E7D479620AE62316C13796B89F78" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F1B8BF26DDA61D8F35CBC13796B87023_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4249E7D479620AE62316C13796B89F78" xlink:to="loc_us-gaap_ClassOfStockDomain_F1B8BF26DDA61D8F35CBC13796B87023_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F1B8BF26DDA61D8F35CBC13796B87023" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4249E7D479620AE62316C13796B89F78" xlink:to="loc_us-gaap_ClassOfStockDomain_F1B8BF26DDA61D8F35CBC13796B87023" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_5ADDDF9927E8E6B81786C13796B86634" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_F1B8BF26DDA61D8F35CBC13796B87023" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_5ADDDF9927E8E6B81786C13796B86634" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_401CF8C0DB608605A470C13796B8A144" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_401CF8C0DB608605A470C13796B8A144" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_401CF8C0DB608605A470C13796B8A144" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_401CF8C0DB608605A470C13796B8A144" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApolloMedicalHoldingsIncMember" xlink:label="loc_ameh_ApolloMedicalHoldingsIncMember_814C2089A70FFB60F1B8C13796B97094" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F" xlink:to="loc_ameh_ApolloMedicalHoldingsIncMember_814C2089A70FFB60F1B8C13796B97094" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ConcourseDiagnosticSurgeryCenterLlcMember" xlink:label="loc_ameh_ConcourseDiagnosticSurgeryCenterLlcMember_80EC04A1C0A0C99F09D7C13796B9BFC8" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_8FAC1367201695141C43C13796B8A84F" xlink:to="loc_ameh_ConcourseDiagnosticSurgeryCenterLlcMember_80EC04A1C0A0C99F09D7C13796B9BFC8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis" xlink:label="loc_srt_OwnershipAxis_02863090B644F0A83DAAC13796B9B3EF" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_srt_OwnershipAxis_02863090B644F0A83DAAC13796B9B3EF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_02863090B644F0A83DAAC13796B9B3EF" xlink:to="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_02863090B644F0A83DAAC13796B9B3EF" xlink:to="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MaverickMedicalGroupIncMember" xlink:label="loc_ameh_MaverickMedicalGroupIncMember_7B5D892A3F5CDE1D636FC13796B903F2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19" xlink:to="loc_ameh_MaverickMedicalGroupIncMember_7B5D892A3F5CDE1D636FC13796B903F2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_E255CD6959B3F680321EC13796BAA059" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19" xlink:to="loc_ameh_AccountableHealthCareIPAMember_E255CD6959B3F680321EC13796BAA059" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareAcquisitionPartnersLlcMember" xlink:label="loc_ameh_UniversalCareAcquisitionPartnersLlcMember_E2D65C8B70460C8CC7B2C13796BAEA12" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768BBAE79AD66E7AD8AAC13796B99B19" xlink:to="loc_ameh_UniversalCareAcquisitionPartnersLlcMember_E2D65C8B70460C8CC7B2C13796BAEA12" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_3CA1FD4AF3BF090C83A1C13796BA0B8D" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ameh_DescriptionOfBusinessTable_B27CDF00B31E71BB5850C13796B4724E" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_3CA1FD4AF3BF090C83A1C13796BA0B8D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_3CA1FD4AF3BF090C83A1C13796BA0B8D" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_3CA1FD4AF3BF090C83A1C13796BA0B8D" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlphaCareMedicalGroupInc.Member" xlink:label="loc_ameh_AlphaCareMedicalGroupInc.Member_B9120A560E838D67F4BDC13796BA41C9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47" xlink:to="loc_ameh_AlphaCareMedicalGroupInc.Member_B9120A560E838D67F4BDC13796BA41C9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_DBE4805F14A1195E8AE6C13796BBD42F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47" xlink:to="loc_ameh_AccountableHealthCareIPAMember_DBE4805F14A1195E8AE6C13796BBD42F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AmgIncMember" xlink:label="loc_ameh_AmgIncMember_43403E6638B77C6263AEC13796BBC44A" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_CB8FD8A6F6DF58DDA44EC13796BA4F47" xlink:to="loc_ameh_AmgIncMember_43403E6638B77C6263AEC13796BBC44A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_InitialFixedTermOfAmendedAndRestatedManagementAndAdministrativeServicesAgreement" xlink:label="loc_ameh_InitialFixedTermOfAmendedAndRestatedManagementAndAdministrativeServicesAgreement_D08E39CF9EFF116C6C8AC13796BBE3A0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_InitialFixedTermOfAmendedAndRestatedManagementAndAdministrativeServicesAgreement_D08E39CF9EFF116C6C8AC13796BBE3A0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableNet" xlink:label="loc_us-gaap_NotesReceivableNet_39A0D4F32303622C891EC13796BCFF9D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_NotesReceivableNet_39A0D4F32303622C891EC13796BCFF9D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FinanceReceivableTermOfReceivable" xlink:label="loc_ameh_FinanceReceivableTermOfReceivable_D26524781D78EA2F1C2EC13796BC8485" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_FinanceReceivableTermOfReceivable_D26524781D78EA2F1C2EC13796BC8485" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FinanceReceivableStatedInterestRate" xlink:label="loc_ameh_FinanceReceivableStatedInterestRate_E2A2C10204B5D0B03DBEC13796BC4B59" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_FinanceReceivableStatedInterestRate_E2A2C10204B5D0B03DBEC13796BC4B59" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FinanceReceivableModificationsSubsequentDefaultInterestRate" xlink:label="loc_ameh_FinanceReceivableModificationsSubsequentDefaultInterestRate_B415FEDCD575C9A03835C13796BC2454" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_FinanceReceivableModificationsSubsequentDefaultInterestRate_B415FEDCD575C9A03835C13796BC2454" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_A88749068576ECFE1888C13796BCEE9B" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_A88749068576ECFE1888C13796BCEE9B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_B5D18BEE322BAA18F037C13796BC1888" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_B5D18BEE322BAA18F037C13796BC1888" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_287A742F6299090CDB42C13796BC6173" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_287A742F6299090CDB42C13796BC6173" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodProxyVotesPercentage" xlink:label="loc_ameh_StockIssuedDuringPeriodProxyVotesPercentage_12F90F40C6BA05C202A3C13796BD42B9" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_StockIssuedDuringPeriodProxyVotesPercentage_12F90F40C6BA05C202A3C13796BD42B9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_AA2FE9544C8750A2E79EC13796BD4F14" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_AA2FE9544C8750A2E79EC13796BD4F14" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_61C885B286889A498E56C13796BDED9F" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_61C885B286889A498E56C13796BDED9F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_EDAB086B7F7E28C48BE7C13796BD4FA4" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_EDAB086B7F7E28C48BE7C13796BD4FA4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_964A67147D2AE8C70739C13796BDC2F3" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_964A67147D2AE8C70739C13796BDC2F3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_35E1FB00517C57A57C15C13796BD49BC" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_35E1FB00517C57A57C15C13796BD49BC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfEnrollees" xlink:label="loc_ameh_NumberOfEnrollees_8F8CB07A842000A60EE1C13796BE9F62" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_NumberOfEnrollees_8F8CB07A842000A60EE1C13796BE9F62" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfEmployees" xlink:label="loc_ameh_NumberOfEmployees_83828BA0B07B46C86BB3C13796BEB8DB" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_NumberOfEmployees_83828BA0B07B46C86BB3C13796BEB8DB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfStores" xlink:label="loc_us-gaap_NumberOfStores_098CD6D3BE85DCC163D8C13796BE592F" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_NumberOfStores_098CD6D3BE85DCC163D8C13796BE592F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfMembersOfFederallyQualifiedHealthPlans" xlink:label="loc_ameh_NumberOfMembersOfFederallyQualifiedHealthPlans_288215CC72EF41647FD0C13796BEFC34" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_NumberOfMembersOfFederallyQualifiedHealthPlans_288215CC72EF41647FD0C13796BEFC34" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfFederallyQualifiedHealthPlans" xlink:label="loc_ameh_NumberOfFederallyQualifiedHealthPlans_E5D25751DD9D5EA31697C13796BEDBFE" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_NumberOfFederallyQualifiedHealthPlans_E5D25751DD9D5EA31697C13796BEDBFE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfFamilyPracticeClinics" xlink:label="loc_ameh_NumberOfFamilyPracticeClinics_565B498E910BDE98D7E2C13796BE7E71" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_ameh_NumberOfFamilyPracticeClinics_565B498E910BDE98D7E2C13796BE7E71" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_FFF6B3161191B8EC8CE1C13796BE158F" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_FFF6B3161191B8EC8CE1C13796BE158F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_2C53685048B2BA6E2409C13796BF74AD" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_DescriptionOfBusinessLineItems_7B1045DB5FCC04817364C13796BB2C17" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_2C53685048B2BA6E2409C13796BF74AD" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/DocumentAndEntityInformation" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EarningsPerShare" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EarningsPerShareAdditionalInformationDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EarningsPerShareBasicNetIncomeLossPerShareIsCalculatedUsingWeightedAverageNumberOfSharesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EarningsPerShareSummaryOfSharesIncludedInDilutedEarningsPerShareDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_17CD9AA94564BC785205C137942398D5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_17CD9AA94564BC785205C137942398D5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_55ED805E0FAD30B974C0C1379423435B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_17CD9AA94564BC785205C137942398D5" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_55ED805E0FAD30B974C0C1379423435B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_DE1A517CAD92E5F1478BC1379423584E_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_55ED805E0FAD30B974C0C1379423435B" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_DE1A517CAD92E5F1478BC1379423584E_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_55ED805E0FAD30B974C0C1379423435B" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_DE1A517CAD92E5F1478BC1379423584E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_8014F25CDEF90DE8581FC1379423449D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_DE1A517CAD92E5F1478BC1379423584E" xlink:to="loc_us-gaap_EmployeeStockOptionMember_8014F25CDEF90DE8581FC1379423449D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_28295366D358A39085C4C13794247A97" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_DE1A517CAD92E5F1478BC1379423584E" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_28295366D358A39085C4C13794247A97" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_66D9528C846421BB0171C1379424D0BC" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_17CD9AA94564BC785205C137942398D5" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_66D9528C846421BB0171C1379424D0BC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_66D9528C846421BB0171C1379424D0BC" xlink:to="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_66D9528C846421BB0171C1379424D0BC" xlink:to="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_B612DCB29C49A9EE63AAC13794249C5D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306" xlink:to="loc_us-gaap_CommonStockMember_B612DCB29C49A9EE63AAC13794249C5D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_B6F3A64183ADBF9943FEC1379425F17D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_B51E7DB2AC9B05487403C13794247306" xlink:to="loc_us-gaap_WarrantMember_B6F3A64183ADBF9943FEC1379425F17D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_DAB438308B35FF379701C1379425EEE5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_DAB438308B35FF379701C1379425EEE5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_F80126E576644DF16995C13794251858" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_F80126E576644DF16995C13794251858" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_196B61F92D13A2F782AAC1379425CAD9" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_196B61F92D13A2F782AAC1379425CAD9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationSharesHeldBackToSecureIndemnificationPercentage" xlink:label="loc_ameh_BusinessCombinationSharesHeldBackToSecureIndemnificationPercentage_AE11A8B5752F3C91B3D3C1379425D3E9" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_93F151A87DF8B2343398C13794255ACB" xlink:to="loc_ameh_BusinessCombinationSharesHeldBackToSecureIndemnificationPercentage_AE11A8B5752F3C91B3D3C1379425D3E9" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EarningsPerShareTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EmployeeBenefitPlan" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/EmployeeBenefitPlanAdditionalInformationDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxes" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_5E3037FBC3FBAAD4EF8AC137954AC51A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_5E3037FBC3FBAAD4EF8AC137954AC51A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityNameAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_6C02FA288528851D0646C137954B1157" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_5E3037FBC3FBAAD4EF8AC137954AC51A" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameAxis_6C02FA288528851D0646C137954B1157" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityNameDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_C9BBC96A1318855C42B6C137954B1D2C_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_6C02FA288528851D0646C137954B1157" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_C9BBC96A1318855C42B6C137954B1D2C_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_6C02FA288528851D0646C137954B1157" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_C9BBC96A1318855C42B6C137954B1D2C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_18C205DEE8C12894FA20C137954BCC49" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_C9BBC96A1318855C42B6C137954B1D2C" xlink:to="loc_us-gaap_DomesticCountryMember_18C205DEE8C12894FA20C137954BCC49" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CaliforniaFranchiseTaxBoardMember" xlink:label="loc_us-gaap_CaliforniaFranchiseTaxBoardMember_319492B41413F2569D76C137954B5301" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_C9BBC96A1318855C42B6C137954B1D2C" xlink:to="loc_us-gaap_CaliforniaFranchiseTaxBoardMember_319492B41413F2569D76C137954B5301" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_13E34DE3FFC86F9BEA73C137954CC3AE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_5E3037FBC3FBAAD4EF8AC137954AC51A" xlink:to="loc_srt_RangeAxis_13E34DE3FFC86F9BEA73C137954CC3AE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_13E34DE3FFC86F9BEA73C137954CC3AE" xlink:to="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_13E34DE3FFC86F9BEA73C137954CC3AE" xlink:to="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_DF13D68D9180B374A2ACC137954C5C26" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51" xlink:to="loc_srt_MinimumMember_DF13D68D9180B374A2ACC137954C5C26" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_EFC3E76B12A877B789F8C137954CBE34" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2A1A3EF165B2DDD53316C137954C1D51" xlink:to="loc_srt_MaximumMember_EFC3E76B12A877B789F8C137954CBE34" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_13E4D075FA06A0F63E93C137954C4BB9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_us-gaap_OperatingLossCarryforwards_13E4D075FA06A0F63E93C137954C4BB9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OperatingLossCarryforwardsExpirationPeriod" xlink:label="loc_ameh_OperatingLossCarryforwardsExpirationPeriod_C5F26FC3B5DD427FF846C137954DF869" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_OperatingLossCarryforwardsExpirationPeriod_C5F26FC3B5DD427FF846C137954DF869" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OperatingLossCarryforwardsNotSubjectToExpiration" xlink:label="loc_ameh_OperatingLossCarryforwardsNotSubjectToExpiration_CAB72CB005E024C971BBC137954D06B0" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_OperatingLossCarryforwardsNotSubjectToExpiration_CAB72CB005E024C971BBC137954D06B0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NonCashReclassificationOfDeferredTaxLiabilities" xlink:label="loc_ameh_NonCashReclassificationOfDeferredTaxLiabilities_FBB9E36F731461639147C137954D3322" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_NonCashReclassificationOfDeferredTaxLiabilities_FBB9E36F731461639147C137954D3322" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_FBAA2A7A5A22436BA855C137954D3228" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_FBAA2A7A5A22436BA855C137954D3228" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_CB6EA509D9329F67358AC137954DB6A8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_CB6EA509D9329F67358AC137954DB6A8" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_OperatingLossCarryforwardsLimitationRateOnTaxableIncome" xlink:label="loc_ameh_OperatingLossCarryforwardsLimitationRateOnTaxableIncome_6867B1AD397D3310644AC137954D203A" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_OperatingLossCarryforwardsLimitationRateOnTaxableIncome_6867B1AD397D3310644AC137954D203A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInDeferredTaxAssetsDueToChangeInEnactedTaxRate" xlink:label="loc_ameh_IncreaseDecreaseInDeferredTaxAssetsDueToChangeInEnactedTaxRate_1DC7FEDB587289B9F338C137954E0DB7" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_IncreaseDecreaseInDeferredTaxAssetsDueToChangeInEnactedTaxRate_1DC7FEDB587289B9F338C137954E0DB7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_IncreaseDecreaseInDeferredTaxLiabilitiesDueToChangeInEnactedTaxRate" xlink:label="loc_ameh_IncreaseDecreaseInDeferredTaxLiabilitiesDueToChangeInEnactedTaxRate_028A591F51E5D56C8A9AC137954E0ED3" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_ameh_IncreaseDecreaseInDeferredTaxLiabilitiesDueToChangeInEnactedTaxRate_028A591F51E5D56C8A9AC137954E0ED3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_05ADA69AF61A717A6EEBC137954E7112" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_8E61FE288F784E2C2EEDC137954C57B6" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_05ADA69AF61A717A6EEBC137954E7112" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxesDeferredTaxAssetsLiabilitiesDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_9B8E8459333ACD880A99C1379543E9D3" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_7C4A54E249D16E36C605C1379541B20C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_9B8E8459333ACD880A99C1379543E9D3" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_7C4A54E249D16E36C605C1379541B20C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_F8522B3639C1FA29C2C0C13795423B06" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_7C4A54E249D16E36C605C1379541B20C" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_F8522B3639C1FA29C2C0C13795423B06" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_5EC1AD00733749737809C137954215A8_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_F8522B3639C1FA29C2C0C13795423B06" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_5EC1AD00733749737809C137954215A8_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_F8522B3639C1FA29C2C0C13795423B06" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_5EC1AD00733749737809C137954215A8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember" xlink:label="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_117C81E7C86B3F086A32C1379542735E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_5EC1AD00733749737809C137954215A8" xlink:to="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_117C81E7C86B3F086A32C1379542735E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_A0A6D6AC7C02F261EB31C1379543173B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_9B8E8459333ACD880A99C1379543E9D3" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_A0A6D6AC7C02F261EB31C1379543173B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesBalance" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_9390AFC35411AD689134C13795431717" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_A0A6D6AC7C02F261EB31C1379543173B" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_9390AFC35411AD689134C13795431717" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_F1E1D6CE3EDC0F08F853C13795432C5A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_A0A6D6AC7C02F261EB31C1379543173B" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_F1E1D6CE3EDC0F08F853C13795432C5A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesReservesOfBusinessesAcquired" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesReservesOfBusinessesAcquired_257AF20AA320AA7E1061C137954371F2" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_A0A6D6AC7C02F261EB31C1379543173B" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesReservesOfBusinessesAcquired_257AF20AA320AA7E1061C137954371F2" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxesIncomeTaxProvisionBenefitDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxesProvisionForIncomeTaxesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IncomeTaxesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IntangibleAssetsNet" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IntangibleAssetsNetAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_A45CFED7C02705367044C13795FA50FF" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_87B38D0F54C8C32EA741C13795F83B16" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_A45CFED7C02705367044C13795FA50FF" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_87B38D0F54C8C32EA741C13795F83B16" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_B0AC0DF1BE96D6B82651C13795F9E377" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_87B38D0F54C8C32EA741C13795F83B16" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_B0AC0DF1BE96D6B82651C13795F9E377" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_480BBFF9C99219893408C13795F9AFE1_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_B0AC0DF1BE96D6B82651C13795F9E377" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_480BBFF9C99219893408C13795F9AFE1_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_B0AC0DF1BE96D6B82651C13795F9E377" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_480BBFF9C99219893408C13795F9AFE1" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ExclusivityMember" xlink:label="loc_ameh_ExclusivityMember_51E95BB712BC27FB67D2C13795F9AFD1" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_480BBFF9C99219893408C13795F9AFE1" xlink:to="loc_ameh_ExclusivityMember_51E95BB712BC27FB67D2C13795F9AFD1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_53B62CB8DD7296A63068C13795F9FE6D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_87B38D0F54C8C32EA741C13795F83B16" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_53B62CB8DD7296A63068C13795F9FE6D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5EE9F21AB04EC3290B0FC13795F929A9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_53B62CB8DD7296A63068C13795F9FE6D" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5EE9F21AB04EC3290B0FC13795F929A9_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5EE9F21AB04EC3290B0FC13795F929A9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_53B62CB8DD7296A63068C13795F9FE6D" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5EE9F21AB04EC3290B0FC13795F929A9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicareLicenseMember" xlink:label="loc_ameh_MedicareLicenseMember_A3D496B4CF1C7D17B488C13795FA2BD8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5EE9F21AB04EC3290B0FC13795F929A9" xlink:to="loc_ameh_MedicareLicenseMember_A3D496B4CF1C7D17B488C13795FA2BD8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_C9147C691B0DB09146F6C13795FA8CBA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_A45CFED7C02705367044C13795FA50FF" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_C9147C691B0DB09146F6C13795FA8CBA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_BD6C4B0430097F368E95C13795FBB499" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_A45CFED7C02705367044C13795FA50FF" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsWrittenOffRelatedToSaleOfBusinessUnit_BD6C4B0430097F368E95C13795FBB499" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IntangibleAssetsNetScheduleOfFutureAmortizationExpenseDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IntangibleAssetsNetScheduleOfIntangibleAssetsDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_882D1B627FB62D31CDE1C13796055EF0" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_552D0BE9CE1E8D07E6F6C13796019A0D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_882D1B627FB62D31CDE1C13796055EF0" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_552D0BE9CE1E8D07E6F6C13796019A0D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_4A15C79633A74ABEE128C137960217BF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_552D0BE9CE1E8D07E6F6C13796019A0D" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_4A15C79633A74ABEE128C137960217BF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9B482CEA6F09CD7A4357C1379602B0BC_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_4A15C79633A74ABEE128C137960217BF" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9B482CEA6F09CD7A4357C1379602B0BC_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9B482CEA6F09CD7A4357C1379602B0BC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_4A15C79633A74ABEE128C137960217BF" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9B482CEA6F09CD7A4357C1379602B0BC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicareLicenseMember" xlink:label="loc_ameh_MedicareLicenseMember_A872A87E7ABEB1646754C1379602134F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9B482CEA6F09CD7A4357C1379602B0BC" xlink:to="loc_ameh_MedicareLicenseMember_A872A87E7ABEB1646754C1379602134F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB2DBE56768A93EF0819C13796029684" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_552D0BE9CE1E8D07E6F6C13796019A0D" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB2DBE56768A93EF0819C13796029684" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB2DBE56768A93EF0819C13796029684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB2DBE56768A93EF0819C13796029684" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkRelationshipsMember" xlink:label="loc_ameh_NetworkRelationshipsMember_9E540DA80C0749FA0BA2C1379603A7A5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:to="loc_ameh_NetworkRelationshipsMember_9E540DA80C0749FA0BA2C1379603A7A5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ManagementContractsMember" xlink:label="loc_ameh_ManagementContractsMember_6F91717A10A8CAFA2346C1379603A12B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:to="loc_ameh_ManagementContractsMember_6F91717A10A8CAFA2346C1379603A12B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MemberRelationshipsMember" xlink:label="loc_ameh_MemberRelationshipsMember_E921F0244F921BF715BFC1379603C3B1" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:to="loc_ameh_MemberRelationshipsMember_E921F0244F921BF715BFC1379603C3B1" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PatientManagementPlatformMember" xlink:label="loc_ameh_PatientManagementPlatformMember_F89F1279C6BF8DC9FA9DC137960489E5" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:to="loc_ameh_PatientManagementPlatformMember_F89F1279C6BF8DC9FA9DC137960489E5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradeNamesMember" xlink:label="loc_us-gaap_TradeNamesMember_7319A08E36F0F2102500C1379604F115" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_607D170B20C9EC004712C1379603700D" xlink:to="loc_us-gaap_TradeNamesMember_7319A08E36F0F2102500C1379604F115" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_0E5D0E06CC62BAFA47F0C13796044D5D" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_552D0BE9CE1E8D07E6F6C13796019A0D" xlink:to="loc_srt_RangeAxis_0E5D0E06CC62BAFA47F0C13796044D5D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_0E5D0E06CC62BAFA47F0C13796044D5D" xlink:to="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_0E5D0E06CC62BAFA47F0C13796044D5D" xlink:to="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_20B61C71AE698186D024C1379604E2B2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D" xlink:to="loc_srt_MinimumMember_20B61C71AE698186D024C1379604E2B2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_1F9F7C6489E3C704F217C13796053370" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_70E5778D7A7548CA6909C13796044E8D" xlink:to="loc_srt_MaximumMember_1F9F7C6489E3C704F217C13796053370" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_ABB4062D36E7F364811AC1379605766C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_882D1B627FB62D31CDE1C13796055EF0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_ABB4062D36E7F364811AC1379605766C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsRollForward" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_7A16F569196EDBF72CE2C1379605CF84" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_882D1B627FB62D31CDE1C13796055EF0" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_7A16F569196EDBF72CE2C1379605CF84" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_6F3244F0FDDB4AB26BE9C1379605C539" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_7A16F569196EDBF72CE2C1379605CF84" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_6F3244F0FDDB4AB26BE9C1379605C539" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefinitelivedIntangibleAssetsAcquired" xlink:label="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_D9AB2296B7B23A0401A9C13796066224" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_7A16F569196EDBF72CE2C1379605CF84" xlink:to="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_D9AB2296B7B23A0401A9C13796066224" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_8725376BFC0A7FE81453C13796062590" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_7A16F569196EDBF72CE2C1379605CF84" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_8725376BFC0A7FE81453C13796062590" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRollForward" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_882D1B627FB62D31CDE1C13796055EF0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_A2E1A26FD692EADB7EE9C13796069C26" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_A2E1A26FD692EADB7EE9C13796069C26" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinitelivedIntangibleAssetsAcquired1" xlink:label="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_D5FFBBF298AFC183A33BC1379606B70D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_D5FFBBF298AFC183A33BC1379606B70D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_6D6B437A37EB6399B834C1379607B22F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_6D6B437A37EB6399B834C1379607B22F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_9C0C0C035550572A0EB5C13796076DAA" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_9C0C0C035550572A0EB5C13796076DAA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_19842EF747334E7600DAC1379607E7B8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_19842EF747334E7600DAC1379607E7B8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_395831413E1C494C0728C13796088B48" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_9B7C3B326FFF7ECF1576C1379606337E" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_395831413E1C494C0728C13796088B48" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/IntangibleAssetsNetTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/InvestmentsInOtherEntities" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/InvestmentsInOtherEntitiesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_42DE512CE52A851CA51FC13795D09C2C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_42DE512CE52A851CA51FC13795D09C2C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_42DE512CE52A851CA51FC13795D09C2C" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_42DE512CE52A851CA51FC13795D09C2C" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LasalleMedicalAssociatesIpaMember" xlink:label="loc_ameh_LasalleMedicalAssociatesIpaMember_F4FFBC16A7CEE6BB660FC13795D1AAEA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_LasalleMedicalAssociatesIpaMember_F4FFBC16A7CEE6BB660FC13795D1AAEA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PacificMedicalImagingAndOncologyCenterIncMember" xlink:label="loc_ameh_PacificMedicalImagingAndOncologyCenterIncMember_1FA820B928B32D8F92C9C13795D14DD9" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_PacificMedicalImagingAndOncologyCenterIncMember_1FA820B928B32D8F92C9C13795D14DD9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareIncMember" xlink:label="loc_ameh_UniversalCareIncMember_2F7F389C3E6CB013FC0FC13795D1FFD5" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_UniversalCareIncMember_2F7F389C3E6CB013FC0FC13795D1FFD5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DiagnosticMedicalGroupMember" xlink:label="loc_ameh_DiagnosticMedicalGroupMember_589CC7A20C041BBB2808C13795D134C0" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_DiagnosticMedicalGroupMember_589CC7A20C041BBB2808C13795D134C0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PacificAmbulatorySurgeryCenterLlcMember" xlink:label="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_A39361D9A018B2DEC768C13795D1DC5B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_A39361D9A018B2DEC768C13795D1DC5B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_203A7E429ECE9B02D187C13795D2F85D" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_AccountableHealthCareIPAMember_203A7E429ECE9B02D187C13795D2F85D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FiveThreeOneW.CollegeLLCMember" xlink:label="loc_ameh_FiveThreeOneW.CollegeLLCMember_89C39EF92EE3895F87D1C13795D24092" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_FiveThreeOneW.CollegeLLCMember_89C39EF92EE3895F87D1C13795D24092" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MWNCommunityHospitalLLCMember" xlink:label="loc_ameh_MWNCommunityHospitalLLCMember_C86289FE5C60F0DE325AC13795D26D00" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_164135479A11CD1946D3C13795D0A993" xlink:to="loc_ameh_MWNCommunityHospitalLLCMember_C86289FE5C60F0DE325AC13795D26D00" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_5334F44036746F64F749C13795D2A204" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_dei_LegalEntityAxis_5334F44036746F64F749C13795D2A204" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_5334F44036746F64F749C13795D2A204" xlink:to="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_5334F44036746F64F749C13795D2A204" xlink:to="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaAndNetworkMedicalManagementMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaAndNetworkMedicalManagementMember_A6E1E00FDC02DCFEEFB1C13795D3C465" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_AlliedPacificOfCaliforniaAndNetworkMedicalManagementMember_A6E1E00FDC02DCFEEFB1C13795D3C465" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_B91AA297717C60AFF782C13795D37FEB" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_AlliedPacificOfCaliforniaAndNetworkMedicalManagementMember_A6E1E00FDC02DCFEEFB1C13795D3C465" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_B91AA297717C60AFF782C13795D37FEB" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_A1910642DEBB5C42C3C1C13795D39017" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_AlliedPacificOfCaliforniaAndNetworkMedicalManagementMember_A6E1E00FDC02DCFEEFB1C13795D3C465" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_A1910642DEBB5C42C3C1C13795D39017" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcLsmaMember" xlink:label="loc_ameh_ApcLsmaMember_DE8B8CA89095776B23E4C13795D3856E" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_ApcLsmaMember_DE8B8CA89095776B23E4C13795D3856E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_4611EA40C4AF98B0E535C13795D3956E" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_AccountableHealthCareIPAMember_4611EA40C4AF98B0E535C13795D3956E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CollegeStreetInvestmentLpMember" xlink:label="loc_ameh_CollegeStreetInvestmentLpMember_3211374508690BCEFFEDC13795D41C89" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_CollegeStreetInvestmentLpMember_3211374508690BCEFFEDC13795D41C89" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AHMCHealthCareMember" xlink:label="loc_ameh_AHMCHealthCareMember_E389577B5C39E90D95BCC13795D48DA8" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_AHMCHealthCareMember_E389577B5C39E90D95BCC13795D48DA8" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Pacific6EnterprisesMember" xlink:label="loc_ameh_Pacific6EnterprisesMember_10C2DDDBBEAA009521C7C13795D40D2A" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_Pacific6EnterprisesMember_10C2DDDBBEAA009521C7C13795D40D2A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_HealthSourceMSOInc.Member" xlink:label="loc_ameh_HealthSourceMSOInc.Member_FD4333FD6A7E2E7BF646C13795D47839" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_53A90E45B595FC2BD351C13795D2F5B3" xlink:to="loc_ameh_HealthSourceMSOInc.Member_FD4333FD6A7E2E7BF646C13795D47839" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis" xlink:label="loc_srt_OwnershipAxis_2A303D360D20883C90B6C13795D48E38" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_srt_OwnershipAxis_2A303D360D20883C90B6C13795D48E38" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_2A303D360D20883C90B6C13795D48E38" xlink:to="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_2A303D360D20883C90B6C13795D48E38" xlink:to="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MWNCommunityHospitalLLCMember" xlink:label="loc_ameh_MWNCommunityHospitalLLCMember_CC01A16686AE927B2AF1C13795D530C0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_MWNCommunityHospitalLLCMember_CC01A16686AE927B2AF1C13795D530C0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcLsmaMember" xlink:label="loc_ameh_ApcLsmaMember_07E8CECB449A1ACCD43EC13795D53C88" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_ApcLsmaMember_07E8CECB449A1ACCD43EC13795D53C88" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_00D9FFC36F5D7D6B3E06C13795D5167D" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_AccountableHealthCareIPAMember_00D9FFC36F5D7D6B3E06C13795D5167D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AHMCHealthCareMember" xlink:label="loc_ameh_AHMCHealthCareMember_D92AF7AA980C004A7DBBC13795D55E57" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_AHMCHealthCareMember_D92AF7AA980C004A7DBBC13795D55E57" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MediPortalLLCMember" xlink:label="loc_ameh_MediPortalLLCMember_8D40BE4DE9976F0FAA29C13795D639DF" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_MediPortalLLCMember_8D40BE4DE9976F0FAA29C13795D639DF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AchievaMedInc.Member" xlink:label="loc_ameh_AchievaMedInc.Member_26112024512B3EB203F7C13795D6E126" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77E7AA23A7C604097A84C13795D4539B" xlink:to="loc_ameh_AchievaMedInc.Member_26112024512B3EB203F7C13795D6E126" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_445CA52EBBE9826D4C77C13795D692F1" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_445CA52EBBE9826D4C77C13795D692F1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0ED15E54A16FAC8C90C2C13795D6A06E_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_445CA52EBBE9826D4C77C13795D692F1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0ED15E54A16FAC8C90C2C13795D6A06E_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0ED15E54A16FAC8C90C2C13795D6A06E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_445CA52EBBE9826D4C77C13795D692F1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0ED15E54A16FAC8C90C2C13795D6A06E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_5445D8FE4B78D1F05014C13795D64478" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0ED15E54A16FAC8C90C2C13795D6A06E" xlink:to="loc_ameh_AccountableHealthCareIPAMember_5445D8FE4B78D1F05014C13795D64478" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_F21F211EB78333217ED5C13795D775EC" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_srt_CounterpartyNameAxis_F21F211EB78333217ED5C13795D775EC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_317742F58FAA1B5BCCD2C13795D7AE0B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_F21F211EB78333217ED5C13795D775EC" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_317742F58FAA1B5BCCD2C13795D7AE0B_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_317742F58FAA1B5BCCD2C13795D7AE0B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_F21F211EB78333217ED5C13795D775EC" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_317742F58FAA1B5BCCD2C13795D7AE0B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.JayMember" xlink:label="loc_ameh_Dr.JayMember_0CC075FBA5E09E5BA369C13795D76E6B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_317742F58FAA1B5BCCD2C13795D7AE0B" xlink:to="loc_ameh_Dr.JayMember_0CC075FBA5E09E5BA369C13795D76E6B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_C1DCAA638F9DCEB24E91C13795D73D8A" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_us-gaap_StatementClassOfStockAxis_C1DCAA638F9DCEB24E91C13795D73D8A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_3BBE25B520C1C3E21EF5C13795D883B9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_C1DCAA638F9DCEB24E91C13795D73D8A" xlink:to="loc_us-gaap_ClassOfStockDomain_3BBE25B520C1C3E21EF5C13795D883B9_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_3BBE25B520C1C3E21EF5C13795D883B9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_C1DCAA638F9DCEB24E91C13795D73D8A" xlink:to="loc_us-gaap_ClassOfStockDomain_3BBE25B520C1C3E21EF5C13795D883B9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_VotingCommonStockTwoMember" xlink:label="loc_ameh_VotingCommonStockTwoMember_6FEC91816F80F201653CC13795D813CA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_3BBE25B520C1C3E21EF5C13795D883B9" xlink:to="loc_ameh_VotingCommonStockTwoMember_6FEC91816F80F201653CC13795D813CA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ContractTypeAxis" xlink:label="loc_ameh_ContractTypeAxis_33EA01C2D5C8ECF90CEDC13795D80483" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_ameh_ContractTypeAxis_33EA01C2D5C8ECF90CEDC13795D80483" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ContractTypeDomain" xlink:label="loc_ameh_ContractTypeDomain_D583F32827EEF217D963C13795D85F27_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ameh_ContractTypeAxis_33EA01C2D5C8ECF90CEDC13795D80483" xlink:to="loc_ameh_ContractTypeDomain_D583F32827EEF217D963C13795D85F27_default" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ContractTypeDomain" xlink:label="loc_ameh_ContractTypeDomain_D583F32827EEF217D963C13795D85F27" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ameh_ContractTypeAxis_33EA01C2D5C8ECF90CEDC13795D80483" xlink:to="loc_ameh_ContractTypeDomain_D583F32827EEF217D963C13795D85F27" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AncillaryServiceContractMember" xlink:label="loc_ameh_AncillaryServiceContractMember_E7187AC8C78C9C28A209C13795D8B978" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ContractTypeDomain_D583F32827EEF217D963C13795D85F27" xlink:to="loc_ameh_AncillaryServiceContractMember_E7187AC8C78C9C28A209C13795D8B978" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_500A109164682D241496C13795D9056B" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_01733BAB5A82362F62EFC13795D0C360" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_500A109164682D241496C13795D9056B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_CEADECC365515DB1BB67C13795D996ED_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_500A109164682D241496C13795D9056B" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_CEADECC365515DB1BB67C13795D996ED_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_CEADECC365515DB1BB67C13795D996ED" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_500A109164682D241496C13795D9056B" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_CEADECC365515DB1BB67C13795D996ED" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_C2C8101362857092FDDAC13795D94408" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_CEADECC365515DB1BB67C13795D996ED" xlink:to="loc_us-gaap_ConvertibleDebtMember_C2C8101362857092FDDAC13795D94408" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfStores" xlink:label="loc_us-gaap_NumberOfStores_8A4AD16854E7E84C9613C13795DA3B35" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_NumberOfStores_8A4AD16854E7E84C9613C13795DA3B35" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfEmployees" xlink:label="loc_ameh_NumberOfEmployees_E3BFD279198BB940AACDC13795DADDD9" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_NumberOfEmployees_E3BFD279198BB940AACDC13795DADDD9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfPatients" xlink:label="loc_ameh_NumberOfPatients_CA4743155A1260782A37C13795DA83A8" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_NumberOfPatients_CA4743155A1260782A37C13795DA83A8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentAggregateCost" xlink:label="loc_us-gaap_EquityMethodInvestmentAggregateCost_79DB2AD8F21EB0CAFBF9C13795DAF685" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_EquityMethodInvestmentAggregateCost_79DB2AD8F21EB0CAFBF9C13795DAF685" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_FCFE215F567D4A00B9F3C13795DAF83F" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_FCFE215F567D4A00B9F3C13795DAF83F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_1D9D1F3F9A8AD8D54AB5C13795DA32BB" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_1D9D1F3F9A8AD8D54AB5C13795DA32BB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="loc_us-gaap_EquityMethodInvestments_F7FDC66B5E9371D12EBBC13795DBA693" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_EquityMethodInvestments_F7FDC66B5E9371D12EBBC13795DBA693" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment" xlink:label="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_0855B5564A0A7317E7E6C13795DB2D5E" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_0855B5564A0A7317E7E6C13795DB2D5E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForFees" xlink:label="loc_us-gaap_PaymentsForFees_015A34040F5BE22190A0C13795DB2BE6" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_PaymentsForFees_015A34040F5BE22190A0C13795DB2BE6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentsPurchaseOfShares" xlink:label="loc_ameh_EquityMethodInvestmentsPurchaseOfShares_F8F2416DC64702180804C13795DB7C67" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentsPurchaseOfShares_F8F2416DC64702180804C13795DB7C67" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStock" xlink:label="loc_ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStock_E420CC1C32672FC8CC81C13795DBA3F5" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStock_E420CC1C32672FC8CC81C13795DBA3F5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital" xlink:label="loc_us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_D0A3608BE14C926B7016C13795DBFB6D" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_D0A3608BE14C926B7016C13795DBFB6D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfMembersOfFederallyQualifiedHealthPlans" xlink:label="loc_ameh_NumberOfMembersOfFederallyQualifiedHealthPlans_3E968693FDD6A3F64338C13795DBC0D4" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_NumberOfMembersOfFederallyQualifiedHealthPlans_3E968693FDD6A3F64338C13795DBC0D4" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfFederallyQualifiedHealthPlans" xlink:label="loc_ameh_NumberOfFederallyQualifiedHealthPlans_A6E4705C1668D990C209C13795DC935E" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_NumberOfFederallyQualifiedHealthPlans_A6E4705C1668D990C209C13795DC935E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LoansPayable" xlink:label="loc_us-gaap_LoansPayable_CE2AD27D88CF30C215C2C13795DC4EFF" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_LoansPayable_CE2AD27D88CF30C215C2C13795DC4EFF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_B0053E367F2B4A332C7FC13795DC09EA" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_B0053E367F2B4A332C7FC13795DC09EA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MembersCapital" xlink:label="loc_us-gaap_MembersCapital_FBECCD1D3FDC6637F61EC13795DC9335" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_MembersCapital_FBECCD1D3FDC6637F61EC13795DC9335" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireRealEstate" xlink:label="loc_us-gaap_PaymentsToAcquireRealEstate_85E07142CFF8905D1F96C13795DC44A5" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_PaymentsToAcquireRealEstate_85E07142CFF8905D1F96C13795DC44A5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentsToEscrowDeposit" xlink:label="loc_ameh_PaymentsToEscrowDeposit_FBA03F8595C6DC357D17C13795DC2DAF" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_PaymentsToEscrowDeposit_FBA03F8595C6DC357D17C13795DC2DAF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_InitialCapitalContribution" xlink:label="loc_ameh_InitialCapitalContribution_D7421F1EAA78E07B82F0C13795DDB04E" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_InitialCapitalContribution_D7421F1EAA78E07B82F0C13795DDB04E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WorkingCapitalContribution" xlink:label="loc_ameh_WorkingCapitalContribution_599B8D0E3613D064F595C13795DDA4D1" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_WorkingCapitalContribution_599B8D0E3613D064F595C13795DDA4D1" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AdditionalWorkingCapitalContribution" xlink:label="loc_ameh_AdditionalWorkingCapitalContribution_1DB9E49F5F4299EC8340C13795DD3C82" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_AdditionalWorkingCapitalContribution_1DB9E49F5F4299EC8340C13795DD3C82" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentMembershipInterestAcquiredPerInterest" xlink:label="loc_ameh_EquityMethodInvestmentMembershipInterestAcquiredPerInterest_98CB66DD0B52C7A9813DC13795DDE972" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentMembershipInterestAcquiredPerInterest_98CB66DD0B52C7A9813DC13795DDE972" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquitySecuritiesWithoutReadilyDeterminableFairValueOwnershipPercentage" xlink:label="loc_ameh_EquitySecuritiesWithoutReadilyDeterminableFairValueOwnershipPercentage_B099A0BDB4940A686D5FC13795DD35A3" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquitySecuritiesWithoutReadilyDeterminableFairValueOwnershipPercentage_B099A0BDB4940A686D5FC13795DD35A3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentOptionsIssuedTermOfOption" xlink:label="loc_ameh_EquityMethodInvestmentOptionsIssuedTermOfOption_45EF8C6C875B95AA3992C13795DD4568" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentOptionsIssuedTermOfOption_45EF8C6C875B95AA3992C13795DD4568" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingTerm" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_53286C923E22AA9D6305C13795DE58C1" xlink:type="locator"/>

<link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_53286C923E22AA9D6305C13795DE58C1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_A4406F6B8A670694AF5CC13795DE642F" xlink:type="locator"/>

<link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_A4406F6B8A670694AF5CC13795DE642F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterests" xlink:label="loc_ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterests_34D9EE0E407AD12FED6DC13795DE9EB2" xlink:type="locator"/>

<link:definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterests_34D9EE0E407AD12FED6DC13795DE9EB2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterestsIfCircumstancesMet" xlink:label="loc_ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterestsIfCircumstancesMet_F60F76AEB6DEEF7B8414C13795DE9F2E" xlink:type="locator"/>

<link:definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentOptionsIssuedOptionToPurchaseAdditionalInterestsIfCircumstancesMet_F60F76AEB6DEEF7B8414C13795DE9F2E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStockWithinFiveYears" xlink:label="loc_ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStockWithinFiveYears_DA79D085A719B3F43B7BC13795DE0CC5" xlink:type="locator"/>

<link:definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentsProportionOfOwnershipInterestInVotingCommonStockWithinFiveYears_DA79D085A719B3F43B7BC13795DE0CC5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentDurationOfInvestment" xlink:label="loc_ameh_EquityMethodInvestmentDurationOfInvestment_243B42BB386F77B89056C13795DE69EA" xlink:type="locator"/>

<link:definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_ameh_EquityMethodInvestmentDurationOfInvestment_243B42BB386F77B89056C13795DE69EA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_61D42E2D1B209E5D1F53C13795DEB5B3" xlink:type="locator"/>

<link:definitionArc order="32" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_61D42E2D1B209E5D1F53C13795DEB5B3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_579F672CE0E7B238B774C13795DFD22D" xlink:type="locator"/>

<link:definitionArc order="33" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_231DBA7126E47FB7AA91C13795D95D6F" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_579F672CE0E7B238B774C13795DFD22D" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/InvestmentsInOtherEntitiesEquityMethodDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E1E80FD5D8F6DBB9B4A4C13795EAB3AF" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_54DD4E1692A537934920C13795E92F25" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E1E80FD5D8F6DBB9B4A4C13795EAB3AF" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_54DD4E1692A537934920C13795E92F25" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7AE0FA6367A4B08F84B0C13795E9B87B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_54DD4E1692A537934920C13795E92F25" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7AE0FA6367A4B08F84B0C13795E9B87B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7AE0FA6367A4B08F84B0C13795E9B87B" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_7AE0FA6367A4B08F84B0C13795E9B87B" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareIncMember" xlink:label="loc_ameh_UniversalCareIncMember_C39C1B20EB439E53B9A9C13795E9DF89" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_UniversalCareIncMember_C39C1B20EB439E53B9A9C13795E9DF89" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LasalleMedicalAssociatesIpaMember" xlink:label="loc_ameh_LasalleMedicalAssociatesIpaMember_C9D2C43A70F95BE1F9FDC13795E95AD6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_LasalleMedicalAssociatesIpaMember_C9D2C43A70F95BE1F9FDC13795E95AD6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DiagnosticMedicalGroupMember" xlink:label="loc_ameh_DiagnosticMedicalGroupMember_140E24C10F36EFC7ED54C13795EAF07F" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_DiagnosticMedicalGroupMember_140E24C10F36EFC7ED54C13795EAF07F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PacificMedicalImagingAndOncologyCenterIncMember" xlink:label="loc_ameh_PacificMedicalImagingAndOncologyCenterIncMember_AC3EB882BC760CA61E57C13795EA32EA" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_PacificMedicalImagingAndOncologyCenterIncMember_AC3EB882BC760CA61E57C13795EA32EA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PacificAmbulatorySurgeryCenterLlcMember" xlink:label="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_298E560B23D14E25CD49C13795EA9474" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_PacificAmbulatorySurgeryCenterLlcMember_298E560B23D14E25CD49C13795EA9474" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_0E65B56C2F24FA15B161C13795EA6A90" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_AccountableHealthCareIPAMember_0E65B56C2F24FA15B161C13795EA6A90" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FiveThreeOneW.CollegeLLCMember" xlink:label="loc_ameh_FiveThreeOneW.CollegeLLCMember_3D4CEF0462FFB9B04955C13795EA7F71" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_FiveThreeOneW.CollegeLLCMember_3D4CEF0462FFB9B04955C13795EA7F71" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MWNCommunityHospitalLLCMember" xlink:label="loc_ameh_MWNCommunityHospitalLLCMember_ED4C6D9D201D8BF2B2E4C13795EA693C" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7357F0435743D1B80512C13795E91340" xlink:to="loc_ameh_MWNCommunityHospitalLLCMember_ED4C6D9D201D8BF2B2E4C13795EA693C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="loc_us-gaap_EquityMethodInvestments_AB222887E5254901EF3CC13795EBE8B2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_E1E80FD5D8F6DBB9B4A4C13795EAB3AF" xlink:to="loc_us-gaap_EquityMethodInvestments_AB222887E5254901EF3CC13795EBE8B2" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/InvestmentsInOtherEntitiesSummarizedBalanceSheetsAndStatementsOfIncomeDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_8FCF82551CC12B04E32FC12C7E64303C" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_D5FC1BEE63381C5BCA40C12C7E634A54" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_8FCF82551CC12B04E32FC12C7E64303C" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_D5FC1BEE63381C5BCA40C12C7E634A54" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_6B90A9ADF09100EF0A61C12C7E63117C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_D5FC1BEE63381C5BCA40C12C7E634A54" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_6B90A9ADF09100EF0A61C12C7E63117C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_6B90A9ADF09100EF0A61C12C7E63117C" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_6B90A9ADF09100EF0A61C12C7E63117C" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LasalleMedicalAssociatesIpaMember" xlink:label="loc_ameh_LasalleMedicalAssociatesIpaMember_D35F03E6E604AFF922A5C12C7E630861" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7" xlink:to="loc_ameh_LasalleMedicalAssociatesIpaMember_D35F03E6E604AFF922A5C12C7E630861" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareIncMember" xlink:label="loc_ameh_UniversalCareIncMember_8C67B322FF6A5CBFC03BC12C7E6479A2" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7" xlink:to="loc_ameh_UniversalCareIncMember_8C67B322FF6A5CBFC03BC12C7E6479A2" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FiveThreeOneW.CollegeLLCMember" xlink:label="loc_ameh_FiveThreeOneW.CollegeLLCMember_257A0236B6D1249989E8C12C7E642EA6" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_17BD4FC9CFF46A82E5D6C12C7E6319B7" xlink:to="loc_ameh_FiveThreeOneW.CollegeLLCMember_257A0236B6D1249989E8C12C7E642EA6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_8FCF82551CC12B04E32FC12C7E64303C" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationCashAndCashEquivalents" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationCashAndCashEquivalents_CDE524EBB1E7FE86CDA3C12C7E64BD54" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationCashAndCashEquivalents_CDE524EBB1E7FE86CDA3C12C7E64BD54" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationReceivables" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationReceivables_A8CE852F6133F4D2E740C12C7E65AD47" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationReceivables_A8CE852F6133F4D2E740C12C7E65AD47" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherCurrentAssets" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherCurrentAssets_5F439944BA4C21839E48C12C7E650C70" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherCurrentAssets_5F439944BA4C21839E48C12C7E650C70" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationLoanReceivables" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationLoanReceivables_BCD7D69697C6957958DAC12C7E6534CA" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationLoanReceivables_BCD7D69697C6957958DAC12C7E6534CA" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationRestrictedCash" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationRestrictedCash_BECF68413E6A730D432DC12C7E65CC04" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationRestrictedCash_BECF68413E6A730D432DC12C7E65CC04" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherAssets" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherAssets_AFAE236C9315B6CE02C9C12C7E65F9A4" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherAssets_AFAE236C9315B6CE02C9C12C7E65F9A4" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationPropertyAndEquipment" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationPropertyAndEquipment_FD9D0C97519F971BCD56C12C7E66400F" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationPropertyAndEquipment_FD9D0C97519F971BCD56C12C7E66400F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_54450BE2EA87F2E7762EC12C7E6603A2" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssetsAbstract_6DB229645641ADCDD715C12C7E64D3D6" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets_54450BE2EA87F2E7762EC12C7E6603A2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_8FCF82551CC12B04E32FC12C7E64303C" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCurrentLiabilities" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCurrentLiabilities_01C416523E97A78E1543C12C7E662E10" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCurrentLiabilities_01C416523E97A78E1543C12C7E662E10" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherLiabilities" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherLiabilities_C5302174C92D4532FF07C12C7E664FA4" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherLiabilities_C5302174C92D4532FF07C12C7E664FA4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationEquity" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationEquity_6E7792D677ADA7F268B6C12C7E663AE9" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationEquity_6E7792D677ADA7F268B6C12C7E663AE9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquity" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquity_E824BE13768896401F5BC12C7E673868" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquityAbstract_DCB48E72A6C039419FA7C12C7E662F46" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilitiesAndEquity_E824BE13768896401F5BC12C7E673868" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_8FCF82551CC12B04E32FC12C7E64303C" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationRevenue" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationRevenue_032AD558A0BFED2B32B5C12C7E67C956" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationRevenue_032AD558A0BFED2B32B5C12C7E67C956" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCostOfSales" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCostOfSales_CA767DEFB42C49B24660C12C7E67DD1B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationCostOfSales_CA767DEFB42C49B24660C12C7E67DD1B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossBeforeIncomeTaxes" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossBeforeIncomeTaxes_974F2AE6257588631441C12C7E67A858" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossBeforeIncomeTaxes_974F2AE6257588631441C12C7E67A858" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossFromContinuingOperationsBeforeExtraordinaryItems" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossFromContinuingOperationsBeforeExtraordinaryItems_52E67EB11D71877D41D2C12C7E676703" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeLossFromContinuingOperationsBeforeExtraordinaryItems_52E67EB11D71877D41D2C12C7E676703" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherIncome" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherIncome_2AA9AB068B5332D03F8DC12C7E68BBA0" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationOtherIncome_2AA9AB068B5332D03F8DC12C7E68BBA0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeTaxesProvisionBenefit" xlink:label="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeTaxesProvisionBenefit_CE42CDADAFE965A21352C12C7E685A8D" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_ameh_EquityMethodInvestmentSummarizedFinancialInformationIncomeTaxesProvisionBenefit_CE42CDADAFE965A21352C12C7E685A8D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" xlink:label="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_0FEE59BF3BDF0CD3B3F0C12C7E68DC82" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationIncomeStatementAbstract_73B8C3EECD46B5E6FF2DC12C7E67E526" xlink:to="loc_us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss_0FEE59BF3BDF0CD3B3F0C12C7E68DC82" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/InvestmentsInOtherEntitiesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LandPropertyAndEquipmentNet" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LandPropertyAndEquipmentNetAdditionalInformationDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LandPropertyAndEquipmentNetScheduleOfLandPropertyAndEquipmentNetDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_B4E17DC113417608AD7EC1379614386F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_B4E17DC113417608AD7EC1379614386F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_98CC3ABD3C95624FD1BFC1379614DB9B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_B4E17DC113417608AD7EC1379614386F" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_98CC3ABD3C95624FD1BFC1379614DB9B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_98CC3ABD3C95624FD1BFC1379614DB9B" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_98CC3ABD3C95624FD1BFC1379614DB9B" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LandMember" xlink:label="loc_us-gaap_LandMember_04A688C097CB8FCF14A6C13796157923" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_LandMember_04A688C097CB8FCF14A6C13796157923" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_6E2BADA58B26D4F2FE90C1379615B4FC" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_BuildingMember_6E2BADA58B26D4F2FE90C1379615B4FC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComputerEquipmentMember" xlink:label="loc_us-gaap_ComputerEquipmentMember_1255C580EC512AD21B12C13796151D25" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_ComputerEquipmentMember_1255C580EC512AD21B12C13796151D25" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_43788D260043B2E53497C1379616BD97" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_43788D260043B2E53497C1379616BD97" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_DB8ACD3CF0AAC8D1B282C1379616160A" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_ConstructionInProgressMember_DB8ACD3CF0AAC8D1B282C1379616160A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_583CAD16F3B618B87ACCC13796168074" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_30361837DCF5BA310DB5C1379615F9FB" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_583CAD16F3B618B87ACCC13796168074" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization" xlink:label="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_0FF7EA7E37F6A74BA407C13796169F1A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_0FF7EA7E37F6A74BA407C13796169F1A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization" xlink:label="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_24266E7424B6DEC07006C1379616B537" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_24266E7424B6DEC07006C1379616B537" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:label="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0DDDABA44BC29B5FE95DC1379617FF28" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_ameh_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0DDDABA44BC29B5FE95DC1379617FF28" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_9B68EB3E05729805417CC1379617E8B7" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_9B68EB3E05729805417CC1379617E8B7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_7B1B47724C3CBC0B49EFC1379617D7C2" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_7B1B47724C3CBC0B49EFC1379617D7C2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_BDB9C0CC7CF9A23A9919C137961721E4" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_BDB9C0CC7CF9A23A9919C137961721E4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaap_DepreciationAndAmortization_F8F70ECA4FFE010A9BD1C13796179414" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A8C921153D20DC7AC713C137961606C7" xlink:to="loc_us-gaap_DepreciationAndAmortization_F8F70ECA4FFE010A9BD1C13796179414" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LandPropertyAndEquipmentNetTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/Leases" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeLeaseDescriptionLineItems" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeLeaseDescriptionTable" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_D58AE407504063ADB520C4DD0F113F88" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_D58AE407504063ADB520C4DD0F113F88" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_E36946E9E5FEEC8456C2C4DD0F115846" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_D58AE407504063ADB520C4DD0F113F88" xlink:to="loc_srt_RangeAxis_E36946E9E5FEEC8456C2C4DD0F115846" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_E36946E9E5FEEC8456C2C4DD0F115846" xlink:to="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_E36946E9E5FEEC8456C2C4DD0F115846" xlink:to="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_F4ABECCE3CE4FF1C60FAC4DD0F12D815" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B" xlink:to="loc_srt_MinimumMember_F4ABECCE3CE4FF1C60FAC4DD0F12D815" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_1456ED0C315BEC696F61C4DD0F1267E9" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_B113E053593B18F76D98C4DD0F12144B" xlink:to="loc_srt_MaximumMember_1456ED0C315BEC696F61C4DD0F1267E9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_C1BB24AC872EA209CD7FC4DD0F13DA65" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_C1BB24AC872EA209CD7FC4DD0F13DA65" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeFinanceLeaseTermOfContract1" xlink:label="loc_us-gaap_LesseeFinanceLeaseTermOfContract1_4AD516C1A72B935934B9C4DD0F13E5C5" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LesseeFinanceLeaseTermOfContract1_4AD516C1A72B935934B9C4DD0F13E5C5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_62E5207673317F04D05FC4DD0F1394A4" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_62E5207673317F04D05FC4DD0F1394A4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeFinanceLeaseRenewalTerm1" xlink:label="loc_us-gaap_LesseeFinanceLeaseRenewalTerm1_72C223F25D81F34ED305C4DD0F139921" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LesseeFinanceLeaseRenewalTerm1_72C223F25D81F34ED305C4DD0F139921" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_0AE3C64681CB001C74ADC4DD0F132C15" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_0AE3C64681CB001C74ADC4DD0F132C15" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasedAssetsGross" xlink:label="loc_us-gaap_CapitalLeasedAssetsGross_8739222553DBD00BEB7CC4F27D1810E4" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_CapitalLeasedAssetsGross_8739222553DBD00BEB7CC4F27D1810E4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_9EDA7F0D881610D2EF52C4DD0F1393F2" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_9EDA7F0D881610D2EF52C4DD0F1393F2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesLesseeBalanceSheetAssetsByMajorClassAccumulatedDeprecation" xlink:label="loc_us-gaap_CapitalLeasesLesseeBalanceSheetAssetsByMajorClassAccumulatedDeprecation_67249F8761CFD8AF7481C4F9D442FC2A" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_CapitalLeasesLesseeBalanceSheetAssetsByMajorClassAccumulatedDeprecation_67249F8761CFD8AF7481C4F9D442FC2A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_us-gaap_LeaseAndRentalExpense_00CED87A32870CE092D0C4DD0F143943" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_96B2D90D5CBF0E445B3DC4DD0F129C94" xlink:to="loc_us-gaap_LeaseAndRentalExpense_00CED87A32870CE092D0C4DD0F143943" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesComponentsOfLeaseExpenseDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesFutureMinimumPaymentsUnderNonCancelableLeasesAfterAdoptionOf842Details" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesFutureMinimumPaymentsUnderNonCancelableLeasesPriorToAdoptionOf842Details" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesOtherInformationRelatedToLeasesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LeasesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LoansReceivableAndLoansReceivableRelatedParties" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/LoansReceivableAndLoansReceivableRelatedPartiesAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_B623B4BDCF613AA2ACC2C12C7E4D5154" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_B623B4BDCF613AA2ACC2C12C7E4D5154" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivableTypeDomain" xlink:label="loc_us-gaap_ReceivableTypeDomain_B7831DC617A3B130B9EDC12C7E4ED4B4_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_B623B4BDCF613AA2ACC2C12C7E4D5154" xlink:to="loc_us-gaap_ReceivableTypeDomain_B7831DC617A3B130B9EDC12C7E4ED4B4_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivableTypeDomain" xlink:label="loc_us-gaap_ReceivableTypeDomain_B7831DC617A3B130B9EDC12C7E4ED4B4" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_B623B4BDCF613AA2ACC2C12C7E4D5154" xlink:to="loc_us-gaap_ReceivableTypeDomain_B7831DC617A3B130B9EDC12C7E4ED4B4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceReceivablesMember" xlink:label="loc_us-gaap_FinanceReceivablesMember_C827047EBB4807E7AFD3C12C7E4E9593" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_B7831DC617A3B130B9EDC12C7E4ED4B4" xlink:to="loc_us-gaap_FinanceReceivablesMember_C827047EBB4807E7AFD3C12C7E4E9593" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_342994D6712ABAA82F69C12C7E4EA011" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_342994D6712ABAA82F69C12C7E4EA011" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_342994D6712ABAA82F69C12C7E4EA011" xlink:to="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_342994D6712ABAA82F69C12C7E4EA011" xlink:to="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.ArteagaConvertibleSecuredPromissoryNoteMember" xlink:label="loc_ameh_Dr.ArteagaConvertibleSecuredPromissoryNoteMember_2490650F5983FDEFAFEFC12C7E4FB3A6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B" xlink:to="loc_ameh_Dr.ArteagaConvertibleSecuredPromissoryNoteMember_2490650F5983FDEFAFEFC12C7E4FB3A6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DrJayLoanMember" xlink:label="loc_ameh_DrJayLoanMember_5CA1F536210F5A7D9143C12C7E4F5B9E" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_4E6B74B16C39D9B474E1C12C7E4EE33B" xlink:to="loc_ameh_DrJayLoanMember_5CA1F536210F5A7D9143C12C7E4F5B9E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_8B7E386EA26C56C48B65C12C7E4FE92A" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_us-gaap_VariableRateAxis_8B7E386EA26C56C48B65C12C7E4FE92A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_346384A089E6747481AAC12C7E501AA2_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_8B7E386EA26C56C48B65C12C7E4FE92A" xlink:to="loc_us-gaap_VariableRateDomain_346384A089E6747481AAC12C7E501AA2_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_346384A089E6747481AAC12C7E501AA2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_8B7E386EA26C56C48B65C12C7E4FE92A" xlink:to="loc_us-gaap_VariableRateDomain_346384A089E6747481AAC12C7E501AA2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrimeRateMember" xlink:label="loc_us-gaap_PrimeRateMember_1AA64AEC780F23E970F2C12C7E50BFFF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_346384A089E6747481AAC12C7E501AA2" xlink:to="loc_us-gaap_PrimeRateMember_1AA64AEC780F23E970F2C12C7E50BFFF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis" xlink:label="loc_srt_OwnershipAxis_A40343C4C28466BB0C4AC12C7E50C061" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_srt_OwnershipAxis_A40343C4C28466BB0C4AC12C7E50C061" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_EC9F99D977FB8C88F728C12C7E5022EC_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_A40343C4C28466BB0C4AC12C7E50C061" xlink:to="loc_srt_OwnershipDomain_EC9F99D977FB8C88F728C12C7E5022EC_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_EC9F99D977FB8C88F728C12C7E5022EC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_A40343C4C28466BB0C4AC12C7E50C061" xlink:to="loc_srt_OwnershipDomain_EC9F99D977FB8C88F728C12C7E5022EC" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LmaMember" xlink:label="loc_ameh_LmaMember_397CFF975906E95E96DFC12C7E50DAEF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_EC9F99D977FB8C88F728C12C7E5022EC" xlink:to="loc_ameh_LmaMember_397CFF975906E95E96DFC12C7E50DAEF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_2F4B4C6A40724BED1BEDC12C7E51D313" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_srt_CounterpartyNameAxis_2F4B4C6A40724BED1BEDC12C7E51D313" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D8F5CC192D8FC6AF5F42C12C7E51FA99_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_2F4B4C6A40724BED1BEDC12C7E51D313" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D8F5CC192D8FC6AF5F42C12C7E51FA99_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D8F5CC192D8FC6AF5F42C12C7E51FA99" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_2F4B4C6A40724BED1BEDC12C7E51D313" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D8F5CC192D8FC6AF5F42C12C7E51FA99" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Dr.JayMember" xlink:label="loc_ameh_Dr.JayMember_3A08654176367A93E714C12C7E519EC4" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D8F5CC192D8FC6AF5F42C12C7E51FA99" xlink:to="loc_ameh_Dr.JayMember_3A08654176367A93E714C12C7E519EC4" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_2A763F5E4B8F44AE2100C12C7E51D75E" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_dei_LegalEntityAxis_2A763F5E4B8F44AE2100C12C7E51D75E" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_960371254E66CC3D36EFC12C7E520C18_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_2A763F5E4B8F44AE2100C12C7E51D75E" xlink:to="loc_dei_EntityDomain_960371254E66CC3D36EFC12C7E520C18_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_960371254E66CC3D36EFC12C7E520C18" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_2A763F5E4B8F44AE2100C12C7E51D75E" xlink:to="loc_dei_EntityDomain_960371254E66CC3D36EFC12C7E520C18" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcMember" xlink:label="loc_ameh_ApcMember_049E4AECDFF524770DBBC12C7E52BF31" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_960371254E66CC3D36EFC12C7E520C18" xlink:to="loc_ameh_ApcMember_049E4AECDFF524770DBBC12C7E52BF31" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_49D288362E84AEA8D2FAC12C7E528845" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_49D288362E84AEA8D2FAC12C7E528845" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7B431BDB69A7CDB04ADC12C7E526FD6_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_49D288362E84AEA8D2FAC12C7E528845" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7B431BDB69A7CDB04ADC12C7E526FD6_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7B431BDB69A7CDB04ADC12C7E526FD6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_49D288362E84AEA8D2FAC12C7E528845" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7B431BDB69A7CDB04ADC12C7E526FD6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AccountableHealthCareIPAMember" xlink:label="loc_ameh_AccountableHealthCareIPAMember_E3D007C5EC1C0149A789C12C7E52C19A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A7B431BDB69A7CDB04ADC12C7E526FD6" xlink:to="loc_ameh_AccountableHealthCareIPAMember_E3D007C5EC1C0149A789C12C7E52C19A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_85A8C267B530D6AED7F5C12C7E5368FB" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5DD5801DBE25BB422F69C12C7E4DA26F" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_85A8C267B530D6AED7F5C12C7E5368FB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_96464CBBBA13B2D47531C12C7E53637F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_85A8C267B530D6AED7F5C12C7E5368FB" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_96464CBBBA13B2D47531C12C7E53637F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_96464CBBBA13B2D47531C12C7E53637F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_85A8C267B530D6AED7F5C12C7E5368FB" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_96464CBBBA13B2D47531C12C7E53637F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareIncMember" xlink:label="loc_ameh_UniversalCareIncMember_9285840BB8F1C4C45CCAC12C7E53B733" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_96464CBBBA13B2D47531C12C7E53637F" xlink:to="loc_ameh_UniversalCareIncMember_9285840BB8F1C4C45CCAC12C7E53B733" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableNet" xlink:label="loc_us-gaap_NotesReceivableNet_C019620AE0D1076874EBC12C7E540973" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_NotesReceivableNet_C019620AE0D1076874EBC12C7E540973" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_512C86F52CC8CA7A4D23C12C7E54A01A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_512C86F52CC8CA7A4D23C12C7E54A01A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FCCA25BCA3F94441E607C12C7E541D75" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_FCCA25BCA3F94441E607C12C7E541D75" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FinancingReceivableConvertibleToCommonStockPercentageOfOutstandingSharesConvertible" xlink:label="loc_ameh_FinancingReceivableConvertibleToCommonStockPercentageOfOutstandingSharesConvertible_EAF3347F585B581E5BD6C12C7E542512" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_ameh_FinancingReceivableConvertibleToCommonStockPercentageOfOutstandingSharesConvertible_EAF3347F585B581E5BD6C12C7E542512" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityMethodInvestmentConversionOfFinanceReceivableOwnershipPercentageUponConversion" xlink:label="loc_ameh_EquityMethodInvestmentConversionOfFinanceReceivableOwnershipPercentageUponConversion_69C0DB070007F208C2F9C12C7E540204" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_ameh_EquityMethodInvestmentConversionOfFinanceReceivableOwnershipPercentageUponConversion_69C0DB070007F208C2F9C12C7E540204" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_72A61E2FC7498E48F8ECC12C7E55DED8" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_72A61E2FC7498E48F8ECC12C7E55DED8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8A06E0C4E310B0211FD7C12C7E559345" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8A06E0C4E310B0211FD7C12C7E559345" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3CD314D2FEF4CD73EB42C12C7E55E633" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3CD314D2FEF4CD73EB42C12C7E55E633" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeRemeasurementGain" xlink:label="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeRemeasurementGain_79EE94504A80546006DCC12C7E557490" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeRemeasurementGain_79EE94504A80546006DCC12C7E557490" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AdvancedForWorkingCapital" xlink:label="loc_ameh_AdvancedForWorkingCapital_68DF72C4AFEDE9454C52C12C7E556EE6" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_ameh_AdvancedForWorkingCapital_68DF72C4AFEDE9454C52C12C7E556EE6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LineOfCreditFacilityAdditionalAdvances" xlink:label="loc_ameh_LineOfCreditFacilityAdditionalAdvances_7FEDC9546E7EB9F98088C12C7E55947F" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_ameh_LineOfCreditFacilityAdditionalAdvances_7FEDC9546E7EB9F98088C12C7E55947F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedParties" xlink:label="loc_us-gaap_LoansAndLeasesReceivableRelatedParties_CD05DECE874F75FD39FBC12C7E557B8D" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_F7A37596819EA5DC63D5C12C7E54D926" xlink:to="loc_us-gaap_LoansAndLeasesReceivableRelatedParties_CD05DECE874F75FD39FBC12C7E557B8D" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MedicalLiabilities" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MedicalLiabilitiesScheduleOfMedicalLiabilitiesDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MedicalLiabilitiesTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquity" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityApcDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsidiarySaleOfStockLineItems" xlink:label="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_FB3EEE3DF76389D3DB28CA224BD9C8EA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:to="loc_dei_LegalEntityAxis_FB3EEE3DF76389D3DB28CA224BD9C8EA" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_AFCAA43B4A440E363A52CA224BDAFADB_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_FB3EEE3DF76389D3DB28CA224BD9C8EA" xlink:to="loc_dei_EntityDomain_AFCAA43B4A440E363A52CA224BDAFADB_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_AFCAA43B4A440E363A52CA224BDAFADB" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_FB3EEE3DF76389D3DB28CA224BD9C8EA" xlink:to="loc_dei_EntityDomain_AFCAA43B4A440E363A52CA224BDAFADB" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_D82CFD46E4E62EE57BF8CA224BDAE47D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_AFCAA43B4A440E363A52CA224BDAFADB" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_D82CFD46E4E62EE57BF8CA224BDAE47D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_68F1BF00A3340CD6392ECA4DB65F85FD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_68F1BF00A3340CD6392ECA4DB65F85FD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AD1F0777A26C8D1E3C82CA4DB6634A59_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_68F1BF00A3340CD6392ECA4DB65F85FD" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AD1F0777A26C8D1E3C82CA4DB6634A59_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AD1F0777A26C8D1E3C82CA4DB6634A59" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_68F1BF00A3340CD6392ECA4DB65F85FD" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AD1F0777A26C8D1E3C82CA4DB6634A59" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AmgIncMember" xlink:label="loc_ameh_AmgIncMember_8B7E048808D3CBF96B89CA4DB765DA45" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AD1F0777A26C8D1E3C82CA4DB6634A59" xlink:to="loc_ameh_AmgIncMember_8B7E048808D3CBF96B89CA4DB765DA45" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_E403FE022BDC7FCBC38ECA224BD82905" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:to="loc_srt_CounterpartyNameAxis_E403FE022BDC7FCBC38ECA224BD82905" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_CC38D9F5730D68A8712CCA224BD8E98F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_E403FE022BDC7FCBC38ECA224BD82905" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_CC38D9F5730D68A8712CCA224BD8E98F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_CC38D9F5730D68A8712CCA224BD8E98F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_E403FE022BDC7FCBC38ECA224BD82905" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_CC38D9F5730D68A8712CCA224BD8E98F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_APAMHMedicalCorporationMember" xlink:label="loc_ameh_APAMHMedicalCorporationMember_97199E1CEB6401C09F8CCA224BD91566" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_CC38D9F5730D68A8712CCA224BD8E98F" xlink:to="loc_ameh_APAMHMedicalCorporationMember_97199E1CEB6401C09F8CCA224BD91566" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_E1EE91975F585BC383F4CA224BD78D64" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_E1EE91975F585BC383F4CA224BD78D64" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_91BDD148A5820E3091F7CA224BD70FA5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_E1EE91975F585BC383F4CA224BD78D64" xlink:to="loc_us-gaap_RelatedPartyDomain_91BDD148A5820E3091F7CA224BD70FA5_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_91BDD148A5820E3091F7CA224BD70FA5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_E1EE91975F585BC383F4CA224BD78D64" xlink:to="loc_us-gaap_RelatedPartyDomain_91BDD148A5820E3091F7CA224BD70FA5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_8AED7CA2EA9234459F4CCA224BD7373B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_91BDD148A5820E3091F7CA224BD70FA5" xlink:to="loc_srt_AffiliatedEntityMember_8AED7CA2EA9234459F4CCA224BD7373B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_CF28636543120CF8E490CA224BD8812F" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_E49B0C448A973E01FF28CA224BD646DE" xlink:to="loc_us-gaap_StatementClassOfStockAxis_CF28636543120CF8E490CA224BD8812F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_6CF2DEC7E596A466D415CA224BD80767_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_CF28636543120CF8E490CA224BD8812F" xlink:to="loc_us-gaap_ClassOfStockDomain_6CF2DEC7E596A466D415CA224BD80767_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_6CF2DEC7E596A466D415CA224BD80767" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_CF28636543120CF8E490CA224BD8812F" xlink:to="loc_us-gaap_ClassOfStockDomain_6CF2DEC7E596A466D415CA224BD80767" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_BF2E1185A7F54EBADFB9CA224BD8AE0E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_6CF2DEC7E596A466D415CA224BD80767" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_BF2E1185A7F54EBADFB9CA224BD8AE0E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_7394B08303A147EFE5C3CA4DB59B79D7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_7394B08303A147EFE5C3CA4DB59B79D7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_DEE73C8C1A7D3ECF4253CA5E41FF11AB" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_DEE73C8C1A7D3ECF4253CA5E41FF11AB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_FA25D8051E1F6CFE5976CA4DB5FEBEDC" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_FA25D8051E1F6CFE5976CA4DB5FEBEDC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_801BE4B83382295B3B8CCA224BDD7454" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_801BE4B83382295B3B8CCA224BDD7454" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_AB7149926700CA9FDED3CA224BDD47D6" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_AB7149926700CA9FDED3CA224BDD47D6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_84B85604800296D7A38BCA224BDD806E" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_2878F9F901F8E1F613A1CA224BDC646C" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_84B85604800296D7A38BCA224BDD806E" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityDividendsAndTreasuryStockDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_B77455340EB03431F4C4C1379480DFFC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:to="loc_dei_LegalEntityAxis_B77455340EB03431F4C4C1379480DFFC" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_B77455340EB03431F4C4C1379480DFFC" xlink:to="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_B77455340EB03431F4C4C1379480DFFC" xlink:to="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncMember" xlink:label="loc_ameh_NetworkMedicalManagementIncMember_9D53F111B8E660753F0BC13794804453" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:to="loc_ameh_NetworkMedicalManagementIncMember_9D53F111B8E660753F0BC13794804453" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CDSCMember" xlink:label="loc_ameh_CDSCMember_A6A8E4F1D3F63966F75DC137948123BD" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:to="loc_ameh_CDSCMember_A6A8E4F1D3F63966F75DC137948123BD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaIPAMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaIPAMember_1413DB3ED0F099B5752FC1379481E5C3" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:to="loc_ameh_AlliedPacificOfCaliforniaIPAMember_1413DB3ED0F099B5752FC1379481E5C3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_5103939DABA9905AA3E9C13794819E40" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_9FF3DD6A1F3AC2B9D11EC137948057E6" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_5103939DABA9905AA3E9C13794819E40" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_004D04399E9888CB6001C137948129AB" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:to="loc_us-gaap_TitleOfIndividualAxis_004D04399E9888CB6001C137948129AB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_84BA83DA572D1229F45BC13794815736_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_004D04399E9888CB6001C137948129AB" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_84BA83DA572D1229F45BC13794815736_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_004D04399E9888CB6001C137948129AB" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_84BA83DA572D1229F45BC13794815736" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcCommonStockMember" xlink:label="loc_ameh_ApcCommonStockMember_7BD9B9EF57548BB8DB7CC1379482BB71" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_84BA83DA572D1229F45BC13794815736" xlink:to="loc_ameh_ApcCommonStockMember_7BD9B9EF57548BB8DB7CC1379482BB71" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_BEFBAD7C48C5FEC66F62C13794826B5E" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_BEFBAD7C48C5FEC66F62C13794826B5E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F65E32F00C5F8107E126C1379482B974_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BEFBAD7C48C5FEC66F62C13794826B5E" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F65E32F00C5F8107E126C1379482B974_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F65E32F00C5F8107E126C1379482B974" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BEFBAD7C48C5FEC66F62C13794826B5E" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F65E32F00C5F8107E126C1379482B974" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncNmmMember" xlink:label="loc_ameh_NetworkMedicalManagementIncNmmMember_D22DB31175C234EBE235C13794826E2B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F65E32F00C5F8107E126C1379482B974" xlink:to="loc_ameh_NetworkMedicalManagementIncNmmMember_D22DB31175C234EBE235C13794826E2B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_D36D32050E2A9E525129C1379483273F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_5852238A86D20A7479A4C13794808971" xlink:to="loc_srt_CounterpartyNameAxis_D36D32050E2A9E525129C1379483273F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_D36D32050E2A9E525129C1379483273F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_D36D32050E2A9E525129C1379483273F" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_C252383BA0563C0F86BDC13794831BDF" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_C252383BA0563C0F86BDC13794831BDF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificofCaliforniaBrokerageAccountMember" xlink:label="loc_ameh_AlliedPacificofCaliforniaBrokerageAccountMember_8DAAEA3A001DEDEBEC03C13794833DDA" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_80756B413808B3CCF77CC137948365AE" xlink:to="loc_ameh_AlliedPacificofCaliforniaBrokerageAccountMember_8DAAEA3A001DEDEBEC03C13794833DDA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_931AD76F0728891485ABC1379484DE21" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_931AD76F0728891485ABC1379484DE21" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_B93147FC20E52232FDCBC137948486F2" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_B93147FC20E52232FDCBC137948486F2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockCommonShares" xlink:label="loc_us-gaap_TreasuryStockCommonShares_C082CDBA0470FF67A061C1379484ABA9" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_TreasuryStockCommonShares_C082CDBA0470FF67A061C1379484ABA9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_E742E782D2EEC33B0B78C1379484E7B0" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_TreasuryStockValue_E742E782D2EEC33B0B78C1379484E7B0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased" xlink:label="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_16774355F3ED435BDE47C13794849A34" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_17D5B81E242A3EFE4B57C137948371D4" xlink:to="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_16774355F3ED435BDE47C13794849A34" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityEquityIncentivePlansDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_20AB876FEE7FF845D176C13794F35019" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:to="loc_srt_RangeAxis_20AB876FEE7FF845D176C13794F35019" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_20AB876FEE7FF845D176C13794F35019" xlink:to="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_20AB876FEE7FF845D176C13794F35019" xlink:to="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_15C265096CB66D377886C13794F48F32" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F" xlink:to="loc_srt_MinimumMember_15C265096CB66D377886C13794F48F32" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_35C9F280D6071FC2F31FC13794F4E6E5" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5F092A9E6885548F0FBFC13794F4363F" xlink:to="loc_srt_MaximumMember_35C9F280D6071FC2F31FC13794F4E6E5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_0B3858FB937D748DFDA5C13794F50354" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:to="loc_us-gaap_TitleOfIndividualAxis_0B3858FB937D748DFDA5C13794F50354" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_0B3858FB937D748DFDA5C13794F50354" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_0B3858FB937D748DFDA5C13794F50354" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcStockOptionMember" xlink:label="loc_ameh_ApcStockOptionMember_3C005CE7A0465D3556BCC13794F57D87" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F" xlink:to="loc_ameh_ApcStockOptionMember_3C005CE7A0465D3556BCC13794F57D87" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_DD1979B7FD2327883CA2C13794F571A6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F" xlink:to="loc_us-gaap_DirectorMember_DD1979B7FD2327883CA2C13794F571A6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ExecutiveOfficerMember" xlink:label="loc_us-gaap_ExecutiveOfficerMember_9965C544A0C07097D50EC13794F5035D" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_E06B4336445160D76F6CC13794F5CD2F" xlink:to="loc_us-gaap_ExecutiveOfficerMember_9965C544A0C07097D50EC13794F5035D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_6527CF806909AD6BD62DC13794F6F3AF" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:to="loc_srt_CounterpartyNameAxis_6527CF806909AD6BD62DC13794F6F3AF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_683E790CC43C0E278EA2C13794F6EB6D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_6527CF806909AD6BD62DC13794F6F3AF" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_683E790CC43C0E278EA2C13794F6EB6D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_683E790CC43C0E278EA2C13794F6EB6D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_6527CF806909AD6BD62DC13794F6F3AF" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_683E790CC43C0E278EA2C13794F6EB6D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_A1C5431C8B7855A99306C13794F6E33F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_683E790CC43C0E278EA2C13794F6EB6D" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_A1C5431C8B7855A99306C13794F6E33F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_4B6854FFCA9F04ECFD47C13794F65FF5" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_D7350604CAED02D6B86CC13794F3315B" xlink:to="loc_us-gaap_AwardTypeAxis_4B6854FFCA9F04ECFD47C13794F65FF5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_4B6854FFCA9F04ECFD47C13794F65FF5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_4B6854FFCA9F04ECFD47C13794F65FF5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityIncentivePlanTwentyTenMember" xlink:label="loc_ameh_EquityIncentivePlanTwentyTenMember_0A8001EB5FCD52B6A1ECC13794F70017" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:to="loc_ameh_EquityIncentivePlanTwentyTenMember_0A8001EB5FCD52B6A1ECC13794F70017" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityIncentivePlanTwentyThirteenMember" xlink:label="loc_ameh_EquityIncentivePlanTwentyThirteenMember_4CE92984CDE8B08AF031C13794F78E48" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:to="loc_ameh_EquityIncentivePlanTwentyThirteenMember_4CE92984CDE8B08AF031C13794F78E48" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_EquityIncentivePlanTwentyFifteenMember" xlink:label="loc_ameh_EquityIncentivePlanTwentyFifteenMember_AF338D7AE3C0ADB28E6EC13794F70356" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:to="loc_ameh_EquityIncentivePlanTwentyFifteenMember_AF338D7AE3C0ADB28E6EC13794F70356" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_0FEAAE70605CE54DCEF3C13794F7754B" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C30B11A163147C1A4070C13794F7414D" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_0FEAAE70605CE54DCEF3C13794F7754B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_803649849E5B58DF7417C13794F8D7F7" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_803649849E5B58DF7417C13794F8D7F7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_75B798701ADB277F6467C13794F87B4F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_75B798701ADB277F6467C13794F87B4F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_0F0AC8ADF71E5C1DC0AFC13794F8F97A" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_0F0AC8ADF71E5C1DC0AFC13794F8F97A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_EF731FC2A6E2A0EACE02C13794F82ED3" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_EF731FC2A6E2A0EACE02C13794F82ED3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_ECB9414876B2AB7069A4C13794F81D74" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_ECB9414876B2AB7069A4C13794F81D74" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_1D7B57BBFB87F63E4A55C13794F95961" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_1D7B57BBFB87F63E4A55C13794F95961" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriod" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriod_0164E655D595473379A5C13794F9C168" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriod_0164E655D595473379A5C13794F9C168" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriodNet" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriodNet_CC01F23208BDE1A1A0C6C13794F9C118" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardCashlessOptionsExercisesInPeriodNet_CC01F23208BDE1A1A0C6C13794F9C118" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_0E7DA6E49EA11A2A16A5C13794F9CED0" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_0E7DA6E49EA11A2A16A5C13794F9CED0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_8817736280F54B5E20A5C13794F9C1F7" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_8817736280F54B5E20A5C13794F9C1F7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_9CBD40B8AF9F8DF5DCD3C13794F948AE" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_9CBD40B8AF9F8DF5DCD3C13794F948AE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_0124B7FD8F102896A761C13794F98A38" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensation_0124B7FD8F102896A761C13794F98A38" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerProvider" xlink:label="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerProvider_2E91368E66C41DD6B855C13794FA535C" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerProvider_2E91368E66C41DD6B855C13794FA535C" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerPreferredProvider" xlink:label="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerPreferredProvider_1E2ACC83B7C7CDC20498C13794FA174D" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOfOptionsIssuedPerPreferredProvider_1E2ACC83B7C7CDC20498C13794FA174D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_F62E8EF044BA73B1F010C13794FA46DE" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_F62E8EF044BA73B1F010C13794FA46DE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_8CF01EEC79FC4B87F6AFC13794FA822C" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_8CF01EEC79FC4B87F6AFC13794FA822C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent" xlink:label="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_36D8CCC6BA167C334959C13794FA4D39" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_36D8CCC6BA167C334959C13794FA4D39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition_D89A86DDC74ED07C67FEC13794FAE5E0" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_AE6E24C0154BBC2C472FC13794F75CCC" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition_D89A86DDC74ED07C67FEC13794FAE5E0" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityScheduleOfStockOptionsActivityDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8556399275397D2A66D1C13794D25EAA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8556399275397D2A66D1C13794D25EAA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_0BA486CAFE387743F869C13794D28030" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8556399275397D2A66D1C13794D25EAA" xlink:to="loc_srt_CounterpartyNameAxis_0BA486CAFE387743F869C13794D28030" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_F59253E7D90134E846F1C13794D37A46_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_0BA486CAFE387743F869C13794D28030" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_F59253E7D90134E846F1C13794D37A46_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_F59253E7D90134E846F1C13794D37A46" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_0BA486CAFE387743F869C13794D28030" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_F59253E7D90134E846F1C13794D37A46" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_FBBFBCC023BADA59F970C13794D33B42" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_F59253E7D90134E846F1C13794D37A46" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_FBBFBCC023BADA59F970C13794D33B42" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_85E7D29F9466E154082EC13794D4F305" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_85E7D29F9466E154082EC13794D4F305" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_E57299BDD7ED936E1BD1C13794D4B8BC" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_E57299BDD7ED936E1BD1C13794D4B8BC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_85CCB82DAC6514971DA5C13794D48AE8" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_85CCB82DAC6514971DA5C13794D48AE8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_1379DC958B5E52F8D7E1C13794D47731" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_9FD89998744D128F76E7C13794D36DED" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_1379DC958B5E52F8D7E1C13794D47731" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_62CF28075CE460D331D7C13794D5E495" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_62CF28075CE460D331D7C13794D5E495" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_171011B774E1CA1354E1C13794D5B294" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_171011B774E1CA1354E1C13794D5B294" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1800A963DDA8378419E4C13794D52DAB" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1800A963DDA8378419E4C13794D52DAB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4ED327B75BECCB9E1852C13794D51711" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_4BFD956CE16EAFBF15A7C13794D50E24" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4ED327B75BECCB9E1852C13794D51711" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_B49B3BFAA9B5821BC5E9C13794D68F4C" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_B49B3BFAA9B5821BC5E9C13794D68F4C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_27B19B5DBBD4216B02CDC13794D694BE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_B49B3BFAA9B5821BC5E9C13794D68F4C" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_27B19B5DBBD4216B02CDC13794D694BE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_B9CA6F26F7FEF4DF9F3FC13794D617C7" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_BEA56D9E91DB49C195E1C13794D3D763" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_B9CA6F26F7FEF4DF9F3FC13794D617C7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_75FF3E5A0C1EEF1E5565C13794D7EB2B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_B9CA6F26F7FEF4DF9F3FC13794D617C7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_75FF3E5A0C1EEF1E5565C13794D7EB2B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_CC98646F7AD9118068B8C13794D74830" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_B9CA6F26F7FEF4DF9F3FC13794D617C7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_CC98646F7AD9118068B8C13794D74830" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsForfeitedIntrinsicValue" xlink:label="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsForfeitedIntrinsicValue_9D6DA4BFB01BF8FF30E0C13794D76982" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_B9CA6F26F7FEF4DF9F3FC13794D617C7" xlink:to="loc_ameh_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsForfeitedIntrinsicValue_9D6DA4BFB01BF8FF30E0C13794D76982" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityShareholdersEquityDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_480569898C223EF68615CA224BC19FAE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_TitleOfIndividualAxis_480569898C223EF68615CA224BC19FAE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_4BA584E6A296F0E82A99CA224BC22F2D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_480569898C223EF68615CA224BC19FAE" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_4BA584E6A296F0E82A99CA224BC22F2D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_4BA584E6A296F0E82A99CA224BC22F2D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_480569898C223EF68615CA224BC19FAE" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_4BA584E6A296F0E82A99CA224BC22F2D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FormerShareholdersOfNmmMember" xlink:label="loc_ameh_FormerShareholdersOfNmmMember_1B4BA34D36541B6617FACA224BC2A468" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_4BA584E6A296F0E82A99CA224BC22F2D" xlink:to="loc_ameh_FormerShareholdersOfNmmMember_1B4BA34D36541B6617FACA224BC2A468" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingAxis" xlink:label="loc_us-gaap_VestingAxis_C054F81907139B0FAE7ECA224BC27965" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_VestingAxis_C054F81907139B0FAE7ECA224BC27965" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingDomain" xlink:label="loc_us-gaap_VestingDomain_F59D2C1F14BB49CAEC36CA224BC28CF5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VestingAxis_C054F81907139B0FAE7ECA224BC27965" xlink:to="loc_us-gaap_VestingDomain_F59D2C1F14BB49CAEC36CA224BC28CF5_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VestingAxis_C054F81907139B0FAE7ECA224BC27965" xlink:to="loc_us-gaap_VestingDomain_F59D2C1F14BB49CAEC36CA224BC28CF5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_12A3D1DE20C2DA8BB05CCA224BC3614A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_F59D2C1F14BB49CAEC36CA224BC28CF5" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_12A3D1DE20C2DA8BB05CCA224BC3614A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_B1712759260D12EB32DACA224BC34BDB" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_B1712759260D12EB32DACA224BC34BDB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_B1712759260D12EB32DACA224BC34BDB" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_B1712759260D12EB32DACA224BC34BDB" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Warrant1Member" xlink:label="loc_ameh_Warrant1Member_791561C36891ACA92DE0CA224BC3BE6A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3" xlink:to="loc_ameh_Warrant1Member_791561C36891ACA92DE0CA224BC3BE6A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_Warrant2Member" xlink:label="loc_ameh_Warrant2Member_665ED23002A021258AF4CA224BC4A741" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_F5590E56A5B15B33EB17CA224BC363D3" xlink:to="loc_ameh_Warrant2Member_665ED23002A021258AF4CA224BC4A741" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_2E84BD49F4F97BE3A19DCA224BC47FD8" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_2E84BD49F4F97BE3A19DCA224BC47FD8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_1C13B0A821F4F5086D49CA224BC4BDAD_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_2E84BD49F4F97BE3A19DCA224BC47FD8" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_1C13B0A821F4F5086D49CA224BC4BDAD_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_2E84BD49F4F97BE3A19DCA224BC47FD8" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_1C13B0A821F4F5086D49CA224BC4BDAD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FirstRepurchaseMember" xlink:label="loc_ameh_FirstRepurchaseMember_2E307C61D14A55954582CA224BC4AF70" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_1C13B0A821F4F5086D49CA224BC4BDAD" xlink:to="loc_ameh_FirstRepurchaseMember_2E307C61D14A55954582CA224BC4AF70" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_SecondRepurchaseMember" xlink:label="loc_ameh_SecondRepurchaseMember_A4BA0236B0A76C0457BFCA224BC4DEB6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_1C13B0A821F4F5086D49CA224BC4BDAD" xlink:to="loc_ameh_SecondRepurchaseMember_A4BA0236B0A76C0457BFCA224BC4DEB6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_75B744EA9E94E1DFDFB3CA224BC45F3D" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_75B744EA9E94E1DFDFB3CA224BC45F3D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_978E9AA7F8AC1AAEE1C7CA224BC5C559_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_75B744EA9E94E1DFDFB3CA224BC45F3D" xlink:to="loc_us-gaap_EquityComponentDomain_978E9AA7F8AC1AAEE1C7CA224BC5C559_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_978E9AA7F8AC1AAEE1C7CA224BC5C559" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_75B744EA9E94E1DFDFB3CA224BC45F3D" xlink:to="loc_us-gaap_EquityComponentDomain_978E9AA7F8AC1AAEE1C7CA224BC5C559" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_B6565EF496D8B12A7800CA224BC53D1F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_978E9AA7F8AC1AAEE1C7CA224BC5C559" xlink:to="loc_us-gaap_CommonStockMember_B6565EF496D8B12A7800CA224BC53D1F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_AF48B4AD8AA8ED1CF6D8CA224BC52629" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_AF48B4AD8AA8ED1CF6D8CA224BC52629" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C3F1C087EA27F50D3017CA224BC5E350_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_AF48B4AD8AA8ED1CF6D8CA224BC52629" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C3F1C087EA27F50D3017CA224BC5E350_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C3F1C087EA27F50D3017CA224BC5E350" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_AF48B4AD8AA8ED1CF6D8CA224BC52629" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C3F1C087EA27F50D3017CA224BC5E350" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncNmmMember" xlink:label="loc_ameh_NetworkMedicalManagementIncNmmMember_A126266520A1261787FFCA224BC63C9F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C3F1C087EA27F50D3017CA224BC5E350" xlink:to="loc_ameh_NetworkMedicalManagementIncNmmMember_A126266520A1261787FFCA224BC63C9F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_F6666457C3D089C99FF7CA224BC6BEA1" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_F6666457C3D089C99FF7CA224BC6BEA1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_CFCF83A8892BE2C924E3CA224BC656A7_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_F6666457C3D089C99FF7CA224BC6BEA1" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_CFCF83A8892BE2C924E3CA224BC656A7_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_F6666457C3D089C99FF7CA224BC6BEA1" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_CFCF83A8892BE2C924E3CA224BC656A7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrivatePlacementMember" xlink:label="loc_us-gaap_PrivatePlacementMember_AC686DEAF953342ABB88CA224BC60B5F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_CFCF83A8892BE2C924E3CA224BC656A7" xlink:to="loc_us-gaap_PrivatePlacementMember_AC686DEAF953342ABB88CA224BC60B5F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_AC3FA90B097D614E86D5CA224BC7DDAB" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D3F028D9668585AD0E63CA224BC11B49" xlink:to="loc_us-gaap_StatementClassOfStockAxis_AC3FA90B097D614E86D5CA224BC7DDAB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_AC3FA90B097D614E86D5CA224BC7DDAB" xlink:to="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_AC3FA90B097D614E86D5CA224BC7DDAB" xlink:to="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_960EC9052C9D635158C3CA224BC797D1" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_960EC9052C9D635158C3CA224BC797D1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_DF8D0612DB72C1D762E3CA224BC7AED6" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_8138C46E89DC164EA98CCA224BC7E982" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_DF8D0612DB72C1D762E3CA224BC7AED6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_65F80FF528506C43097BCA224BC89820" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_65F80FF528506C43097BCA224BC89820" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_DE4DE3D5CBF59FA9E3E3CA224BC8D101" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_DE4DE3D5CBF59FA9E3E3CA224BC8D101" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_023526CEDC9C897CA96ACA224BC840F0" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_023526CEDC9C897CA96ACA224BC840F0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_28028AD9FAF06A95E85DCA224BC8A504" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_28028AD9FAF06A95E85DCA224BC8A504" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9C90EF2A36DB071035F1CA224BC88FE2" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9C90EF2A36DB071035F1CA224BC88FE2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_EEA62F075CC08D95BB46CA224BC8BD33" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_EEA62F075CC08D95BB46CA224BC8BD33" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2A136B712F7B3F18F055CA224BC9BEFD" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2A136B712F7B3F18F055CA224BC9BEFD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_us-gaap_GainLossOnInvestments_3BB5C638C43A2A780FE4CA224BC977E7" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_GainLossOnInvestments_3BB5C638C43A2A780FE4CA224BC977E7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_BC088E0D743E23775773CA224BC98E5E" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_BC088E0D743E23775773CA224BC98E5E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BC5E74C7E7CCDE850185CA224BC998B1" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BC5E74C7E7CCDE850185CA224BC998B1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_0F4A40CDBC7849CCFFEBCA224BC908E6" xlink:type="locator"/>

<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_0F4A40CDBC7849CCFFEBCA224BC908E6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockShareSubscribedButUnissuedSubscriptionsReceivable" xlink:label="loc_us-gaap_CommonStockShareSubscribedButUnissuedSubscriptionsReceivable_45763BAE14A0CD585F3ACA224BCA41A9" xlink:type="locator"/>

<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_CommonStockShareSubscribedButUnissuedSubscriptionsReceivable_45763BAE14A0CD585F3ACA224BCA41A9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesSubscribedButUnissued" xlink:label="loc_us-gaap_CommonStockSharesSubscribedButUnissued_518DB607B4EB353A79A8CA224BCA7068" xlink:type="locator"/>

<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_CommonStockSharesSubscribedButUnissued_518DB607B4EB353A79A8CA224BCA7068" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_A21AA327A71CECEA8E7FCA224BCAE464" xlink:type="locator"/>

<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ShareBasedCompensation_A21AA327A71CECEA8E7FCA224BCAE464" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionSharePrice" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_A3E858248660F217028ECA224BCA9F11" xlink:type="locator"/>

<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_BusinessAcquisitionSharePrice_A3E858248660F217028ECA224BCA9F11" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_02F667F144143F29AA97CA224BCA6914" xlink:type="locator"/>

<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_02F667F144143F29AA97CA224BCA6914" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_07287BB2DDBF29954D9CCA224BCAB781" xlink:type="locator"/>

<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_07287BB2DDBF29954D9CCA224BCAB781" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_2975A0BAE5F7AC94AD81CA224BCB5F7F" xlink:type="locator"/>

<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_2975A0BAE5F7AC94AD81CA224BCB5F7F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedPerTransaction" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedPerTransaction_B4CDA00797B3B02F39FBCA224BCB3BBC" xlink:type="locator"/>

<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedPerTransaction_B4CDA00797B3B02F39FBCA224BCB3BBC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_5C68C93DAF70C78A0FF1CA224BCB1AC2" xlink:type="locator"/>

<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_5C68C93DAF70C78A0FF1CA224BCB1AC2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_263EB1D7F91CEE0584DECA224BCBE170" xlink:type="locator"/>

<link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_263EB1D7F91CEE0584DECA224BCBE170" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumberOfSharesHoldbackPercentage" xlink:label="loc_ameh_NumberOfSharesHoldbackPercentage_8812FD910EB5C2D5C49FCA224BCBA97F" xlink:type="locator"/>

<link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_ameh_NumberOfSharesHoldbackPercentage_8812FD910EB5C2D5C49FCA224BCBA97F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_C15A58B77F97ED165EC6CA224BCB2EC7" xlink:type="locator"/>

<link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_C15A58B77F97ED165EC6CA224BCB2EC7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_BusinessCombinationNumberOfSharesHeldBack" xlink:label="loc_ameh_BusinessCombinationNumberOfSharesHeldBack_85C84E670AE2A65A032DCA224BCC55D2" xlink:type="locator"/>

<link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_ameh_BusinessCombinationNumberOfSharesHeldBack_85C84E670AE2A65A032DCA224BCC55D2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2D173CE365A0C13C3242CA224BCC376F" xlink:type="locator"/>

<link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2D173CE365A0C13C3242CA224BCC376F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_373714C959186626F9A2CA224BCC7ECD" xlink:type="locator"/>

<link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_SharesIssued_373714C959186626F9A2CA224BCC7ECD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodShareConversionOfNotes" xlink:label="loc_ameh_StockIssuedDuringPeriodShareConversionOfNotes_17B6358C30A84FB8386DCA224BCCF595" xlink:type="locator"/>

<link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_ameh_StockIssuedDuringPeriodShareConversionOfNotes_17B6358C30A84FB8386DCA224BCCF595" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodValueConversionOfNotes" xlink:label="loc_ameh_StockIssuedDuringPeriodValueConversionOfNotes_0A90C8B2CB00838AB7A7CA224BCC49E5" xlink:type="locator"/>

<link:definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_ameh_StockIssuedDuringPeriodValueConversionOfNotes_0A90C8B2CB00838AB7A7CA224BCC49E5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_StockIssuedDuringPeriodSharesMerger" xlink:label="loc_ameh_StockIssuedDuringPeriodSharesMerger_2B1FA49D6A7B14C629B9CA224BCC207B" xlink:type="locator"/>

<link:definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_ameh_StockIssuedDuringPeriodSharesMerger_2B1FA49D6A7B14C629B9CA224BCC207B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_96B7A1F26B570CEA5159CA224BCDA4E5" xlink:type="locator"/>

<link:definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_377EBB2A3530393C774BCA224BC7681E" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_96B7A1F26B570CEA5159CA224BCDA4E5" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfRemainingUnrecognizedShareBasedCompensationOfStockOptionDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_60B6C6354510ECD7956BC12C7CAFE4BE" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_B7E78478F3225FBFA8F1C12C7CAECE20" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_60B6C6354510ECD7956BC12C7CAFE4BE" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_B7E78478F3225FBFA8F1C12C7CAECE20" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_AA193E080F542A293A3AC12C7CAEC8C6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_B7E78478F3225FBFA8F1C12C7CAECE20" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_AA193E080F542A293A3AC12C7CAEC8C6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_AE11AC5BFB5B28F8F602C12C7CAE63D7_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_AA193E080F542A293A3AC12C7CAEC8C6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_AE11AC5BFB5B28F8F602C12C7CAE63D7_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_AA193E080F542A293A3AC12C7CAEC8C6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_AE11AC5BFB5B28F8F602C12C7CAE63D7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_078D5AFE1A8C10AA52EDC12C7CAF6D01" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_AE11AC5BFB5B28F8F602C12C7CAE63D7" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_078D5AFE1A8C10AA52EDC12C7CAF6D01" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_87A089775CE19494259AC12C7CAF360D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_60B6C6354510ECD7956BC12C7CAFE4BE" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_87A089775CE19494259AC12C7CAF360D" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfStockOptionActivityUnderBlackScholesOptionDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7EAB7CB7479CD353966EC13794E1A8BE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:to="loc_srt_CounterpartyNameAxis_7EAB7CB7479CD353966EC13794E1A8BE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D453348AA823E2E8DEE0C13794E16BB9_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7EAB7CB7479CD353966EC13794E1A8BE" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D453348AA823E2E8DEE0C13794E16BB9_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D453348AA823E2E8DEE0C13794E16BB9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7EAB7CB7479CD353966EC13794E1A8BE" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D453348AA823E2E8DEE0C13794E16BB9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AlliedPacificOfCaliforniaMember" xlink:label="loc_ameh_AlliedPacificOfCaliforniaMember_143525CCEBFED8BBA592C13794E18B7F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_D453348AA823E2E8DEE0C13794E16BB9" xlink:to="loc_ameh_AlliedPacificOfCaliforniaMember_143525CCEBFED8BBA592C13794E18B7F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_982E6EBEAB7F586892FAC13794E13305" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:to="loc_srt_RangeAxis_982E6EBEAB7F586892FAC13794E13305" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_982E6EBEAB7F586892FAC13794E13305" xlink:to="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_982E6EBEAB7F586892FAC13794E13305" xlink:to="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_E45291B68691FBC1C753C13794E25ECA" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648" xlink:to="loc_srt_MaximumMember_E45291B68691FBC1C753C13794E25ECA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_772BBD988B11278BFD84C13794E29FE4" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_635C365DE64520758AFDC13794E13648" xlink:to="loc_srt_MinimumMember_772BBD988B11278BFD84C13794E29FE4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_73027DEA6B9CD1191930C13794E2B2E2" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:to="loc_us-gaap_TitleOfIndividualAxis_73027DEA6B9CD1191930C13794E2B2E2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_73027DEA6B9CD1191930C13794E2B2E2" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_73027DEA6B9CD1191930C13794E2B2E2" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_D7B14DA2957871358960C13794E23EB0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252" xlink:to="loc_us-gaap_DirectorMember_D7B14DA2957871358960C13794E23EB0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ExecutiveOfficerMember" xlink:label="loc_us-gaap_ExecutiveOfficerMember_0149362E7BAA735BFA44C13794E3CE3A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_482D03C87F8CD0A6CE5EC13794E2C252" xlink:to="loc_us-gaap_ExecutiveOfficerMember_0149362E7BAA735BFA44C13794E3CE3A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_4B4FF2EEC58108F57A32C13794E38EEA" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_00548A5316632EE8BF3CC13794E064CA" xlink:to="loc_us-gaap_AwardTypeAxis_4B4FF2EEC58108F57A32C13794E38EEA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_AF0A17ADD19C9BFF8F79C13794E36B7D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_4B4FF2EEC58108F57A32C13794E38EEA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_AF0A17ADD19C9BFF8F79C13794E36B7D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_AF0A17ADD19C9BFF8F79C13794E36B7D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_4B4FF2EEC58108F57A32C13794E38EEA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_AF0A17ADD19C9BFF8F79C13794E36B7D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_DB99796E41B0310257F3C13794E3F179" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_AF0A17ADD19C9BFF8F79C13794E36B7D" xlink:to="loc_us-gaap_EmployeeStockOptionMember_DB99796E41B0310257F3C13794E3F179" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_C41D560BA19DFFF02BD9C13794E4AA26" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_C41D560BA19DFFF02BD9C13794E4AA26" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMerger" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMerger_4EA564815B832FF245D3C13794E40B75" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMerger_4EA564815B832FF245D3C13794E40B75" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_5F1A7B6ED2A6A6A07E5CC13794E4ABC7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_5F1A7B6ED2A6A6A07E5CC13794E4ABC7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_682236777D30F9B7CDAEC13794E516AB" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_682236777D30F9B7CDAEC13794E516AB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_90B9C45B7A1B8A84AB7CC13794E516AA" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_FF7282F76670BFD9CE2AC13794E4BA50" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_90B9C45B7A1B8A84AB7CC13794E516AA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_744053CD5FD1C4E6E8E9C13794E5F2E4" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_744053CD5FD1C4E6E8E9C13794E5F2E4" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_073EDFAA418AD81A62BDC13794E58AB6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_073EDFAA418AD81A62BDC13794E58AB6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageExercisePrice" xlink:label="loc_ameh_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageExercisePrice_2576A64800C46EC8A1E5C13794E6660D" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:to="loc_ameh_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageExercisePrice_2576A64800C46EC8A1E5C13794E6660D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_60DE82AD6B24E8F3629EC13794E6309C" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_60DE82AD6B24E8F3629EC13794E6309C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_4F0A9D8D53EE108ED3E0C13794E64702" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_4F0A9D8D53EE108ED3E0C13794E64702" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_8EDD7DFC3EB44C4106DFC13794E674CD" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract_0F82962BC908C4A9FBB2C13794E575CB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_8EDD7DFC3EB44C4106DFC13794E674CD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_6A44B18DE38CBAC6C2C9C13794E788FE" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_6A44B18DE38CBAC6C2C9C13794E788FE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_C5DCD869552E32E555E5C13794E7A36B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_C5DCD869552E32E555E5C13794E7A36B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_C55D4DA7E25304263447C13794E7AD77" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_C5DCD869552E32E555E5C13794E7A36B" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_C55D4DA7E25304263447C13794E7AD77" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageRemainingContractualTerm" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageRemainingContractualTerm_2509F6C2C39751039E07C13794E7654B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_C5DCD869552E32E555E5C13794E7A36B" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerWeightedAverageRemainingContractualTerm_2509F6C2C39751039E07C13794E7654B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1_C238120AB65DCFD885F0C13794E7A616" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_C5DCD869552E32E555E5C13794E7A36B" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1_C238120AB65DCFD885F0C13794E7A616" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_25EFBA101A0896107BA4C13794E87961" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_25EFBA101A0896107BA4C13794E87961" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerAggregateIntrinsicValue" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerAggregateIntrinsicValue_5B95E4A571A93A3118FCC13794E83E23" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAcquiredInMergerAggregateIntrinsicValue_5B95E4A571A93A3118FCC13794E83E23" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_9BDA7A50D1D15DF8F726C13794E8893F" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_9BDA7A50D1D15DF8F726C13794E8893F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_02EB8FC9C43AD7916D57C13794E8B629" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_06F15A82137FD1D5F266C13794E736A7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_02EB8FC9C43AD7916D57C13794E8B629" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1568D8B29D6E83A4A197C13794E4FC3A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_F77086BD0539A317CF3AC13794E90C2E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_F77086BD0539A317CF3AC13794E90C2E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_00DBCD45B47DDA6D5E0EC13794E9C7CC" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_00DBCD45B47DDA6D5E0EC13794E9C7CC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_E965525D01D5C352BBEEC13794E98E39" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_E965525D01D5C352BBEEC13794E98E39" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_83156976BC6FA834E8EAC13794E98B65" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_us-gaap_SharePrice_83156976BC6FA834E8EAC13794E98B65" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_D2620A9BD5F968CEB6CEC13794E93A41" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_D2620A9BD5F968CEB6CEC13794E93A41" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate_8BF7908D781FBB977D2CC13794EA4A50" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_BAE2A6C5A1CD7FD54922C13794E846D9" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate_8BF7908D781FBB977D2CC13794EA4A50" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquitySummaryOfWarrantsDetails" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityWarrantsDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_345C5F65D384F9D07F31C137948A8406" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_345C5F65D384F9D07F31C137948A8406" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_D84CF8CBCF31B0089B0FC137948AFDF8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_345C5F65D384F9D07F31C137948A8406" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_D84CF8CBCF31B0089B0FC137948AFDF8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_D84CF8CBCF31B0089B0FC137948AFDF8" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_D84CF8CBCF31B0089B0FC137948AFDF8" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantExercisePriceRangeOneMember" xlink:label="loc_ameh_WarrantExercisePriceRangeOneMember_599A3ABBF1A15241D613C137948B779F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:to="loc_ameh_WarrantExercisePriceRangeOneMember_599A3ABBF1A15241D613C137948B779F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantExercisePriceRangeTwoMember" xlink:label="loc_ameh_WarrantExercisePriceRangeTwoMember_40E8DDEA6924656E8A7DC137948B1953" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:to="loc_ameh_WarrantExercisePriceRangeTwoMember_40E8DDEA6924656E8A7DC137948B1953" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantExercisePriceRangeThreeMember" xlink:label="loc_ameh_WarrantExercisePriceRangeThreeMember_A26A5C3080852346867EC137948BC1D7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:to="loc_ameh_WarrantExercisePriceRangeThreeMember_A26A5C3080852346867EC137948BC1D7" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantExercisePriceRangeFourMember" xlink:label="loc_ameh_WarrantExercisePriceRangeFourMember_37E7E64B41FD1446F41AC137948B671C" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_AE469BEDF9529E38F510C137948AE01D" xlink:to="loc_ameh_WarrantExercisePriceRangeFourMember_37E7E64B41FD1446F41AC137948B671C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_FAE68CF124398ED94547C137948BC4E7" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_345C5F65D384F9D07F31C137948A8406" xlink:to="loc_srt_RangeAxis_FAE68CF124398ED94547C137948BC4E7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_FAE68CF124398ED94547C137948BC4E7" xlink:to="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_FAE68CF124398ED94547C137948BC4E7" xlink:to="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_8FEAA73288835488F455C137948C23AC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5" xlink:to="loc_srt_MinimumMember_8FEAA73288835488F455C137948C23AC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_7F18D47A78EE926746D2C137948CD6C1" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_66BDF75FF76309C209D2C137948B93E5" xlink:to="loc_srt_MaximumMember_7F18D47A78EE926746D2C137948CD6C1" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_9C8F8C3D26EA21E0ED84C137948C9F45" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_9C8F8C3D26EA21E0ED84C137948C9F45" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ClassOfWarrantOrRightIssuedInPeriod" xlink:label="loc_ameh_ClassOfWarrantOrRightIssuedInPeriod_78FB57FC06858417B0E0C137948D964E" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_ameh_ClassOfWarrantOrRightIssuedInPeriod_78FB57FC06858417B0E0C137948D964E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm" xlink:label="loc_ameh_ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm_2362FCF36EA76D51DA4AC137948DD460" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_ameh_ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm_2362FCF36EA76D51DA4AC137948DD460" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ClassOfWarrantOrRightExercisable" xlink:label="loc_ameh_ClassOfWarrantOrRightExercisable_048E27D34BCAFFB772D7C137948DCB43" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_ameh_ClassOfWarrantOrRightExercisable_048E27D34BCAFFB772D7C137948DCB43" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ClassOfWarrantsOrRightWeightedAverageExercisePriceOfWarrants" xlink:label="loc_ameh_ClassOfWarrantsOrRightWeightedAverageExercisePriceOfWarrants_8BDBEF3586CE18E933C9C137948D0DCA" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_D0B02E2DBCC62A48318CC137948C0A4F" xlink:to="loc_ameh_ClassOfWarrantsOrRightWeightedAverageExercisePriceOfWarrants_8BDBEF3586CE18E933C9C137948D0DCA" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/MezzanineAndShareholdersEquityWarrantsNarrativeDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_284F2A572BB949DFBFA0C137949CA682" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_284F2A572BB949DFBFA0C137949CA682" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_4DFFFB3D4FE5191D2AE2C137949D2BCE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_284F2A572BB949DFBFA0C137949CA682" xlink:to="loc_srt_RangeAxis_4DFFFB3D4FE5191D2AE2C137949D2BCE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_4DFFFB3D4FE5191D2AE2C137949D2BCE" xlink:to="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_4DFFFB3D4FE5191D2AE2C137949D2BCE" xlink:to="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_592B1BE410A0CBB45E4CC137949D3902" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674" xlink:to="loc_srt_MinimumMember_592B1BE410A0CBB45E4CC137949D3902" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_590C77CB93EA168045E3C137949D58B7" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_EB7EAF67B1355FDFDE40C137949DD674" xlink:to="loc_srt_MaximumMember_590C77CB93EA168045E3C137949D58B7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_34FEB82DF56647A4D6E9C137949E922C" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_284F2A572BB949DFBFA0C137949CA682" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_34FEB82DF56647A4D6E9C137949E922C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4D92EE305EB602245D59C137949E4A8F_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_34FEB82DF56647A4D6E9C137949E922C" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4D92EE305EB602245D59C137949E4A8F_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4D92EE305EB602245D59C137949E4A8F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_34FEB82DF56647A4D6E9C137949E922C" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4D92EE305EB602245D59C137949E4A8F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrivatePlacementMember" xlink:label="loc_us-gaap_PrivatePlacementMember_C26C5287280ED0B4A861C137949EC6D5" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4D92EE305EB602245D59C137949E4A8F" xlink:to="loc_us-gaap_PrivatePlacementMember_C26C5287280ED0B4A861C137949EC6D5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_98F37E47E605802857CFC137949E7B4E" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_284F2A572BB949DFBFA0C137949CA682" xlink:to="loc_us-gaap_StatementClassOfStockAxis_98F37E47E605802857CFC137949E7B4E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_76345AC6447A763D88E1C137949FFFA2_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_98F37E47E605802857CFC137949E7B4E" xlink:to="loc_us-gaap_ClassOfStockDomain_76345AC6447A763D88E1C137949FFFA2_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_76345AC6447A763D88E1C137949FFFA2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_98F37E47E605802857CFC137949E7B4E" xlink:to="loc_us-gaap_ClassOfStockDomain_76345AC6447A763D88E1C137949FFFA2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_0A50DD4EA93073C6614CC137949F32B3" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_76345AC6447A763D88E1C137949FFFA2" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_0A50DD4EA93073C6614CC137949F32B3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_39B7FFA60257E2EB9124C137949F39D2" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_39B7FFA60257E2EB9124C137949F39D2" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_0542332A5C0C3177B492C137949F85AF" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_0542332A5C0C3177B492C137949F85AF" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardWarrantsExercisesInPeriod" xlink:label="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardWarrantsExercisesInPeriod_EC58D379C1D66EDC1890C13794A00DA9" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_ameh_ShareBasedCompensationArrangementByShareBasedPaymentAwardWarrantsExercisesInPeriod_EC58D379C1D66EDC1890C13794A00DA9" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_WarrantIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_ameh_WarrantIssuedDuringPeriodValueStockOptionsExercised_6EFC3BDA40CF194AE9F2C13794A06E1F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_ameh_WarrantIssuedDuringPeriodValueStockOptionsExercised_6EFC3BDA40CF194AE9F2C13794A06E1F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ShareBasedCompensationArrangementBySharebasedPaymentAwardWarrantExercisableWeightedAverageExercisePrice" xlink:label="loc_ameh_ShareBasedCompensationArrangementBySharebasedPaymentAwardWarrantExercisableWeightedAverageExercisePrice_524D3CB8DB5D66FABB60C13794A09387" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_75AC3CC0C2017E57FF7CC137949FC6BB" xlink:to="loc_ameh_ShareBasedCompensationArrangementBySharebasedPaymentAwardWarrantExercisableWeightedAverageExercisePrice_524D3CB8DB5D66FABB60C13794A09387" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RelatedPartyTransactions" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RelatedPartyTransactionsAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_C1DA93D2E801085A3905C137945FF7E6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:to="loc_dei_LegalEntityAxis_C1DA93D2E801085A3905C137945FF7E6" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_391F9C20CA81CD64ADACC1379460DE52_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_C1DA93D2E801085A3905C137945FF7E6" xlink:to="loc_dei_EntityDomain_391F9C20CA81CD64ADACC1379460DE52_default" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_391F9C20CA81CD64ADACC1379460DE52" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_C1DA93D2E801085A3905C137945FF7E6" xlink:to="loc_dei_EntityDomain_391F9C20CA81CD64ADACC1379460DE52" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NetworkMedicalManagementIncNmmMember" xlink:label="loc_ameh_NetworkMedicalManagementIncNmmMember_918FEE599250BE264DE4C13794604ABE" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_391F9C20CA81CD64ADACC1379460DE52" xlink:to="loc_ameh_NetworkMedicalManagementIncNmmMember_918FEE599250BE264DE4C13794604ABE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_5B93339E97C3763F7B8BC13794607E2A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:to="loc_us-gaap_TitleOfIndividualAxis_5B93339E97C3763F7B8BC13794607E2A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_42B1E3D18BA80BD8D629C1379460AF94_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_5B93339E97C3763F7B8BC13794607E2A" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_42B1E3D18BA80BD8D629C1379460AF94_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_42B1E3D18BA80BD8D629C1379460AF94" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_5B93339E97C3763F7B8BC13794607E2A" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_42B1E3D18BA80BD8D629C1379460AF94" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OfficerMember" xlink:label="loc_us-gaap_OfficerMember_FC8EFC5047DD11402C96C137946166D6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_42B1E3D18BA80BD8D629C1379460AF94" xlink:to="loc_us-gaap_OfficerMember_FC8EFC5047DD11402C96C137946166D6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_863EDB43E4CA8656693BC1379461FD31" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_863EDB43E4CA8656693BC1379461FD31" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_863EDB43E4CA8656693BC1379461FD31" xlink:to="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_863EDB43E4CA8656693BC1379461FD31" xlink:to="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareIncMember" xlink:label="loc_ameh_UniversalCareIncMember_D21F7D832D7B1F9D7258C1379461B4FD" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_UniversalCareIncMember_D21F7D832D7B1F9D7258C1379461B4FD" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_UniversalCareAcquisitionPartnersLlcMember" xlink:label="loc_ameh_UniversalCareAcquisitionPartnersLlcMember_A0399B9FDB8443019740C1379462AB15" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_UniversalCareAcquisitionPartnersLlcMember_A0399B9FDB8443019740C1379462AB15" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ApcShareholdersMember" xlink:label="loc_ameh_ApcShareholdersMember_0F9F166CD92F05E5D80DC13794622692" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_ApcShareholdersMember_0F9F166CD92F05E5D80DC13794622692" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AdvanceDiagnosticSurgeryCenterMember" xlink:label="loc_ameh_AdvanceDiagnosticSurgeryCenterMember_88DF85D8BDBC4B6E80AAC1379462C11F" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_AdvanceDiagnosticSurgeryCenterMember_88DF85D8BDBC4B6E80AAC1379462C11F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicalPropertyPartnersMember" xlink:label="loc_ameh_MedicalPropertyPartnersMember_A78D56E27A0E007C7679C1379462AD47" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_MedicalPropertyPartnersMember_A78D56E27A0E007C7679C1379462AD47" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicalInvestmentGroupLlcMember" xlink:label="loc_ameh_MedicalInvestmentGroupLlcMember_B41DFC2AB082CF92386EC13794625208" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_MedicalInvestmentGroupLlcMember_B41DFC2AB082CF92386EC13794625208" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_CriticalQualityManagementCorpMember" xlink:label="loc_ameh_CriticalQualityManagementCorpMember_B61C556E01E9D21A4AACC13794627DE4" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_CriticalQualityManagementCorpMember_B61C556E01E9D21A4AACC13794627DE4" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_NumenLLCMember" xlink:label="loc_ameh_NumenLLCMember_7EE6D125244CAD59BBAAC1379463260A" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_NumenLLCMember_7EE6D125244CAD59BBAAC1379463260A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AHMCMember" xlink:label="loc_ameh_AHMCMember_DC64AAB99D452FA32587C1379463D89E" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_ameh_AHMCMember_DC64AAB99D452FA32587C1379463D89E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_AffiliatedEntityMember" xlink:label="loc_srt_AffiliatedEntityMember_1C6B974E3385B8B1F182C13794636746" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_E956E504F82D98025F56C13794615A78" xlink:to="loc_srt_AffiliatedEntityMember_1C6B974E3385B8B1F182C13794636746" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_14DC7B68F30CDD06751FC13794631027" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_14DC7B68F30CDD06751FC13794631027" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_4EB812E8DCDFB45299EAC1379463A3D3_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_14DC7B68F30CDD06751FC13794631027" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_4EB812E8DCDFB45299EAC1379463A3D3_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_14DC7B68F30CDD06751FC13794631027" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_4EB812E8DCDFB45299EAC1379463A3D3" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ServiceMember" xlink:label="loc_us-gaap_ServiceMember_573D7036541FEC719694C13794640AF6" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_4EB812E8DCDFB45299EAC1379463A3D3" xlink:to="loc_us-gaap_ServiceMember_573D7036541FEC719694C13794640AF6" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_ConsultingServicesMember" xlink:label="loc_ameh_ConsultingServicesMember_5DCA2130FB98393E9397C1379464608F" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_4EB812E8DCDFB45299EAC1379463A3D3" xlink:to="loc_ameh_ConsultingServicesMember_5DCA2130FB98393E9397C1379464608F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="loc_srt_ConsolidatedEntitiesAxis_2E91CC23205C9798FAD6C1379464C555" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_0A3AD1D0F139251306BDC137945F1605" xlink:to="loc_srt_ConsolidatedEntitiesAxis_2E91CC23205C9798FAD6C1379464C555" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_2E91CC23205C9798FAD6C1379464C555" xlink:to="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_2E91CC23205C9798FAD6C1379464C555" xlink:to="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LmaMember" xlink:label="loc_ameh_LmaMember_8F411BE8FE78C29D7061C13794649A2A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C" xlink:to="loc_ameh_LmaMember_8F411BE8FE78C29D7061C13794649A2A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PmiocMember" xlink:label="loc_ameh_PmiocMember_FBA71F6D56F6907F388CC137946553DE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C" xlink:to="loc_ameh_PmiocMember_FBA71F6D56F6907F388CC137946553DE" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_DmgMember" xlink:label="loc_ameh_DmgMember_A1DC38E501BD176E2B03C1379465070B" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_A969EAB91BEB945C72D6C13794646C2C" xlink:to="loc_ameh_DmgMember_A1DC38E501BD176E2B03C1379465070B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_BB118E3E6BE01BF57A91C13794659519" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_BB118E3E6BE01BF57A91C13794659519" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_4C1D106C50F443CF7351C1379465736B" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_4C1D106C50F443CF7351C1379465736B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_313A692234353F225151C1379465141B" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_RevenueFromRelatedParties_313A692234353F225151C1379465141B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DueFromRelatedParties" xlink:label="loc_us-gaap_DueFromRelatedParties_3748A5C2429ABEB84A9DC13794662582" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_DueFromRelatedParties_3748A5C2429ABEB84A9DC13794662582" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_PaymentMadeToRelatedParty" xlink:label="loc_ameh_PaymentMadeToRelatedParty_5B6FC7CEAD0D79EFCEF5C13794660C73" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_ameh_PaymentMadeToRelatedParty_5B6FC7CEAD0D79EFCEF5C13794660C73" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InsuranceServicesRevenue" xlink:label="loc_us-gaap_InsuranceServicesRevenue_18AEB9B27650F914ED9AC1379466EA55" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_InsuranceServicesRevenue_18AEB9B27650F914ED9AC1379466EA55" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredCreditsAndOtherLiabilities" xlink:label="loc_us-gaap_DeferredCreditsAndOtherLiabilities_F73A173B0F6CE683C2F0C13794663239" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_DeferredCreditsAndOtherLiabilities_F73A173B0F6CE683C2F0C13794663239" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_28C96DB8B494B9394AA1C1379466B8F2" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_A81B3C40EBF715CB45FAC1379465866B" xlink:to="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_28C96DB8B494B9394AA1C1379466B8F2" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RelatedPartyTransactionsScheduleOfRelatedPartyTransactionsDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_E97A9EF86A1A1AD26670C12C7C6235E0" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_3F4D81E95E00D507952BC12C7C61B925" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_E97A9EF86A1A1AD26670C12C7C6235E0" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_3F4D81E95E00D507952BC12C7C61B925" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74C5B286A3CD4B99BD54C12C7C61B115" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_3F4D81E95E00D507952BC12C7C61B925" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74C5B286A3CD4B99BD54C12C7C61B115" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74C5B286A3CD4B99BD54C12C7C61B115" xlink:to="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0_default" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74C5B286A3CD4B99BD54C12C7C61B115" xlink:to="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AHMCMember" xlink:label="loc_ameh_AHMCMember_A7DD7BB03B8B95E7E175C12C7C61B07F" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0" xlink:to="loc_ameh_AHMCMember_A7DD7BB03B8B95E7E175C12C7C61B07F" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_HSMSOMember" xlink:label="loc_ameh_HSMSOMember_F49057A8AC0DBE75E509C12C7C62F62A" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0" xlink:to="loc_ameh_HSMSOMember_F49057A8AC0DBE75E509C12C7C62F62A" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_AurionMember" xlink:label="loc_ameh_AurionMember_7236E661334D3111A038C12C7C6206E7" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_5309540DCB39A07C14BEC12C7C6191A0" xlink:to="loc_ameh_AurionMember_7236E661334D3111A038C12C7C6206E7" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InsuranceServicesRevenue" xlink:label="loc_us-gaap_InsuranceServicesRevenue_CEF43A7E06F3257D722CC12C7C621A14" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_E97A9EF86A1A1AD26670C12C7C6235E0" xlink:to="loc_us-gaap_InsuranceServicesRevenue_CEF43A7E06F3257D722CC12C7C621A14" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ManagementFeeExpense" xlink:label="loc_us-gaap_ManagementFeeExpense_914CBE14C3E60FA46593C12C7C62A547" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_E97A9EF86A1A1AD26670C12C7C6235E0" xlink:to="loc_us-gaap_ManagementFeeExpense_914CBE14C3E60FA46593C12C7C62A547" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty_7249AFE0C28D99DF1D22C12C7C6372EE" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_E97A9EF86A1A1AD26670C12C7C6235E0" xlink:to="loc_us-gaap_RelatedPartyTransactionOtherRevenuesFromTransactionsWithRelatedParty_7249AFE0C28D99DF1D22C12C7C6372EE" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RelatedPartyTransactionsTables" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RevenueRecognition" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/RevenueRecognitionAdditionalInformationDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_5F4AD78AD8084E0D821DC13794493580" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_5F4AD78AD8084E0D821DC13794493580" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_1ACA0A64EB7EB54A3244C137944A2577" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_5F4AD78AD8084E0D821DC13794493580" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_1ACA0A64EB7EB54A3244C137944A2577" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3EDA2D8547EE9FD1648FC137944A2252_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_1ACA0A64EB7EB54A3244C137944A2577" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3EDA2D8547EE9FD1648FC137944A2252_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_1ACA0A64EB7EB54A3244C137944A2577" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3EDA2D8547EE9FD1648FC137944A2252" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_997C82E85CAF277F7C08C137944A2EEC" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3EDA2D8547EE9FD1648FC137944A2252" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_997C82E85CAF277F7C08C137944A2EEC" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityFairValueAdjustment" xlink:label="loc_us-gaap_EquityFairValueAdjustment_B4A1DC6D53CFD09623ECC137944B94F0" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:to="loc_us-gaap_EquityFairValueAdjustment_B4A1DC6D53CFD09623ECC137944B94F0" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_EDBD264D26EE5270E38AC137944B8292" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_EDBD264D26EE5270E38AC137944B8292" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1" xlink:label="loc_us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1_533C1D0E11C0E4505902C137944B4BFA" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:to="loc_us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1_533C1D0E11C0E4505902C137944B4BFA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FreshStartAdjustmentIncreaseDecreaseDeferredIncomeTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_FreshStartAdjustmentIncreaseDecreaseDeferredIncomeTaxLiabilitiesNoncurrent_481FE083EC72BAAFA55FC137944BEAFD" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4E194E86DFA54F4433DBC137944A600F" xlink:to="loc_us-gaap_FreshStartAdjustmentIncreaseDecreaseDeferredIncomeTaxLiabilitiesNoncurrent_481FE083EC72BAAFA55FC137944BEAFD" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/VariableInterestEntitiesVies" xlink:type="extended"/>

<link:definitionLink xlink:role="http://www.apollomed.net/role/VariableInterestEntitiesViesEliminatedUponConsolidationIncludedInAccompanyingConsolidatedBalanceSheetsDetails" xlink:type="extended">

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityLineItems" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:type="locator"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_8B9132F89F303CF04301C451FC2D060B" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_8B9132F89F303CF04301C451FC2D060B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_97CA259D63B40433230FC451FC2E0C3A" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_8B9132F89F303CF04301C451FC2D060B" xlink:to="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_97CA259D63B40433230FC451FC2E0C3A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_9F6C89FAC940129AF92AC451FC2EADC4_default" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_97CA259D63B40433230FC451FC2E0C3A" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_9F6C89FAC940129AF92AC451FC2EADC4_default" xlink:type="arc"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_97CA259D63B40433230FC451FC2E0C3A" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_9F6C89FAC940129AF92AC451FC2EADC4" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_F7C9D75DC8BD64290C58C451FC2E5409" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_9F6C89FAC940129AF92AC451FC2EADC4" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_F7C9D75DC8BD64290C58C451FC2E5409" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_3BAA30393EAA39F5932AC451FC2F13F8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:to="loc_us-gaap_AssetsAbstract_3BAA30393EAA39F5932AC451FC2F13F8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_3BAA30393EAA39F5932AC451FC2F13F8" xlink:to="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80F8F15655A6F0D9EA3CC451FC2F8FC8" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80F8F15655A6F0D9EA3CC451FC2F8FC8" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashCurrent" xlink:label="loc_us-gaap_RestrictedCashCurrent_78000BCF3EC70F1A07CBC451FC2FFDEF" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_RestrictedCashCurrent_78000BCF3EC70F1A07CBC451FC2FFDEF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_90BF1037549691A41B14C451FC3012CD" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_90BF1037549691A41B14C451FC3012CD" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_6C6C472E4307AB2D477FC451FC306147" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_6C6C472E4307AB2D477FC451FC306147" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_74B813D1C1D314166677C451FC300B85" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_74B813D1C1D314166677C451FC300B85" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherReceivablesNetCurrent" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_3522E36F8FF9E23E6E2EC451FC3076D5" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_3522E36F8FF9E23E6E2EC451FC3076D5" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_3DFDD5E5DFCC5A079180C451FC309A3A" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_3DFDD5E5DFCC5A079180C451FC309A3A" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesAndLoansReceivableNetCurrent" xlink:label="loc_us-gaap_NotesAndLoansReceivableNetCurrent_5D1C359E05DBB11D409BC451FC3091AE" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_NotesAndLoansReceivableNetCurrent_5D1C359E05DBB11D409BC451FC3091AE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_NotesReceivableRelatedPartiesCurrent_8BDF15068043CF15136BC451FC309B36" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_NotesReceivableRelatedPartiesCurrent_8BDF15068043CF15136BC451FC309B36" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_7517AE3F631C1EB18767C451FC310ABA" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_E4EFA07B6954F1084DC0C451FC2F16B9" xlink:to="loc_us-gaap_AssetsCurrent_7517AE3F631C1EB18767C451FC310ABA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_3BAA30393EAA39F5932AC451FC2F13F8" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_DC1EDB0985BD4C65AF46C451FC31053E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_DC1EDB0985BD4C65AF46C451FC31053E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_F4981B38F5A77E60C5E2C451FC310CFE" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_F4981B38F5A77E60C5E2C451FC310CFE" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_FA605C247CF332E96C46C451FC31A110" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_Goodwill_FA605C247CF332E96C46C451FC31A110" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DueFromRelatedPartiesNoncurrent" xlink:label="loc_us-gaap_DueFromRelatedPartiesNoncurrent_7539704CAA23E524B2A3C451FC32C128" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_DueFromRelatedPartiesNoncurrent_7539704CAA23E524B2A3C451FC32C128" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="loc_us-gaap_EquityMethodInvestments_3B673B365717B1758C71C451FC32D856" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_EquityMethodInvestments_3B673B365717B1758C71C451FC32D856" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue" xlink:label="loc_us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue_27F10EFFD4D50F66B3E7C451FC32E8BF" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue_27F10EFFD4D50F66B3E7C451FC32E8BF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashNoncurrent" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_66F45F3B893A2929B6A1C451FC32476C" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_66F45F3B893A2929B6A1C451FC32476C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_284FAD2EA350EA49E46FC451FC32195E" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_284FAD2EA350EA49E46FC451FC32195E" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_28C88C6E460878FCD229C451FC32BE56" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_28C88C6E460878FCD229C451FC32BE56" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsNoncurrent" xlink:label="loc_us-gaap_AssetsNoncurrent_4019A71C94F01FDAC3C7C451FC3333DA" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_404450C1C361981102A5C451FC318833" xlink:to="loc_us-gaap_AssetsNoncurrent_4019A71C94F01FDAC3C7C451FC3333DA" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_B71B23494D752B5F97D5C451FC33D6B6" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_3BAA30393EAA39F5932AC451FC2F13F8" xlink:to="loc_us-gaap_Assets_B71B23494D752B5F97D5C451FC33D6B6" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_95934739615E72E7B54FC451FC33B834" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_95934739615E72E7B54FC451FC33B834" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_FiduciaryAccountsPayableCurrent" xlink:label="loc_ameh_FiduciaryAccountsPayableCurrent_A1AD21EBDA4BCE76B585C451FC3302D5" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_ameh_FiduciaryAccountsPayableCurrent_A1AD21EBDA4BCE76B585C451FC3302D5" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_MedicalLiabilitiesCurrent" xlink:label="loc_ameh_MedicalLiabilitiesCurrent_477A0F798FAB888EBB98C451FC340A4B" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_ameh_MedicalLiabilitiesCurrent_477A0F798FAB888EBB98C451FC340A4B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_37E6E8025DAE21457CB4C451FC34B32C" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_TaxesPayableCurrent_37E6E8025DAE21457CB4C451FC34B32C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaap_DividendsPayableCurrent_B4D4BC17C8EAF02FC5DFC451FC34918D" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_DividendsPayableCurrent_B4D4BC17C8EAF02FC5DFC451FC34918D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DueToAffiliateCurrent" xlink:label="loc_us-gaap_DueToAffiliateCurrent_16CE7BCC923DD68BA4E4C451FC34245B" xlink:type="locator"/>

<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_DueToAffiliateCurrent_16CE7BCC923DD68BA4E4C451FC34245B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermBankLoansAndNotesPayable" xlink:label="loc_us-gaap_ShortTermBankLoansAndNotesPayable_ABB10C8E9D32B60ED1BBC451FC348D0D" xlink:type="locator"/>

<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_ShortTermBankLoansAndNotesPayable_ABB10C8E9D32B60ED1BBC451FC348D0D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_3D10B2D05909CD141A17C451FC34F923" xlink:type="locator"/>

<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_3D10B2D05909CD141A17C451FC34F923" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_A0BAFEFD2E70613693F9C451FC34A607" xlink:type="locator"/>

<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_A0BAFEFD2E70613693F9C451FC34A607" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_EC84C0B9880064A9380BC451FC351D3F" xlink:type="locator"/>

<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_5284B77D853DF99927E9C451FC33D473" xlink:to="loc_us-gaap_LiabilitiesCurrent_EC84C0B9880064A9380BC451FC351D3F" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_204840E0038093EF4A89C451FC35250E" xlink:type="locator"/>

<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_204840E0038093EF4A89C451FC35250E" xlink:type="arc"/>

<link:loc xlink:href="ameh-20191231.xsd#ameh_LiabilityForUnissuedEquitySharesNoncurrent" xlink:label="loc_ameh_LiabilityForUnissuedEquitySharesNoncurrent_170786AFB36153ACA89DC451FC35E0AF" xlink:type="locator"/>

<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:to="loc_ameh_LiabilityForUnissuedEquitySharesNoncurrent_170786AFB36153ACA89DC451FC35E0AF" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_FB5F0431B09A52A2F5F7C451FC35163D" xlink:type="locator"/>

<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_FB5F0431B09A52A2F5F7C451FC35163D" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_27FB360DDC7C7C5F78D7C451FC351D12" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_27FB360DDC7C7C5F78D7C451FC351D12" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_D6BA38E7ED48544A9E42C451FC36CD8B" xlink:type="locator"/>

<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E6560432CE4350D0B9D8C451FC356C2C" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_D6BA38E7ED48544A9E42C451FC36CD8B" xlink:type="arc"/>

<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_47F02D4E5E874F456F06C451FC367A44" xlink:type="locator"/>

<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_B5AEC2DF7EA329A614E1C451FC2EB33A" xlink:to="loc_us-gaap_Liabilities_47F02D4E5E874F456F06C451FC367A44" xlink:type="arc"/>

</link:definitionLink>

<link:definitionLink xlink:role="http://www.apollomed.net/role/VariableInterestEntitiesViesTables" xlink:type="extended"/>

</link:linkbase>

16 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/17/23  Apollo Medical Holdings, Inc.     S-8        11/17/23    4:183K                                   Toppan Merrill/FA
11/03/23  Apollo Medical Holdings, Inc.     S-8        11/03/23    4:185K                                   Toppan Merrill/FA
 8/16/23  Apollo Medical Holdings, Inc.     S-3ASR      8/16/23    4:273K                                   Toppan Merrill/FA
 8/16/23  Apollo Medical Holdings, Inc.     S-3ASR      8/16/23    5:797K                                   Toppan Merrill/FA
 8/09/23  Apollo Medical Holdings, Inc.     10-K/A     12/31/22  116:21M                                    Workiva Inc Wde… FA01/FA
 5/10/23  Apollo Medical Holdings, Inc.     10-Q        3/31/23   92:11M                                    Workiva Inc Wde… FA01/FA
 3/01/23  Apollo Medical Holdings, Inc.     10-K       12/31/22  108:72M                                    Workiva Inc Wde… FA01/FA
11/07/22  Apollo Medical Holdings, Inc.     10-Q        9/30/22   93:13M                                    Workiva Inc Wde… FA01/FA
 8/09/22  Apollo Medical Holdings, Inc.     10-Q        6/30/22   92:18M                                    Workiva Inc Wde… FA01/FA
 5/10/22  Apollo Medical Holdings, Inc.     10-Q        3/31/22   90:11M                                    Workiva Inc Wde… FA01/FA
 2/28/22  Apollo Medical Holdings, Inc.     10-K       12/31/21  109:15M                                    Workiva Inc Wde… FA01/FA
11/05/21  Apollo Medical Holdings, Inc.     10-Q        9/30/21   92:12M                                    Workiva Inc Wde… FA01/FA
 8/06/21  Apollo Medical Holdings, Inc.     10-Q        6/30/21   89:13M                                    Workiva Inc Wde… FA01/FA
 3/15/21  Apollo Medical Holdings, Inc.     10-K       12/31/20  116:17M                                    Workiva Inc Wde… FA01/FA
10/16/20  SEC                               UPLOAD¶    11/16/20    2:39K  Apollo Medical Holdings, Inc.
 9/24/20  SEC                               UPLOAD¶    11/16/20    2:43K  Apollo Medical Holdings, Inc.

↑Top

Filing Submission 0001628280-20-003626 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Apollo Medical Holdings, Inc. – ‘10-K’ for 12/31/19 – ‘EX-101.DEF’

On: Monday, 3/16/20, at 4:11pm ET · For: 12/31/19 · Accession #: 1628280-20-3626 · File #: 1-37392

Annual Report — Form 10-K — Sect. 13 / 15(d) – SEA’34Filing Table of Contents

‘EX-101.DEF’ — XBRL Definitions — ameh-20191231_def

This Exhibit is an XBRL XML File.

16 Subsequent Filings that Reference this Filing

Annual Report — Form 10-K — Sect. 13 / 15(d) – SEA’34
Filing Table of Contents