SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Axonics Modulation Technologies, Inc. – ‘10-K’ for 12/31/19 – ‘EX-101.DEF’

On:  Wednesday, 3/4/20, at 4:31pm ET   ·   For:  12/31/19   ·   Accession #:  1603756-20-13   ·   File #:  1-38721

Previous ‘10-K’:  ‘10-K/A’ on 4/30/19 for 12/31/18   ·   Next:  ‘10-K’ on 3/1/21 for 12/31/20   ·   Latest:  ‘10-K/A’ on 4/29/24 for 12/31/23   ·   6 References:   

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 3/04/20  Axonics Modulation Techs, Inc.    10-K       12/31/19   75:9.2M

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.03M 
 2: EX-4.4      Instrument Defining the Rights of Security Holders  HTML     53K 
 3: EX-21.1     Subsidiaries List                                   HTML     22K 
 4: EX-23.1     Consent of Experts or Counsel                       HTML     22K 
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     30K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     30K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     25K 
 8: EX-32.2     Certification -- §906 - SOA'02                      HTML     25K 
23: R1          Cover Page                                          HTML     65K 
61: R2          Consolidated Balance Sheets                         HTML    101K 
67: R3          Consolidated Balance Sheets - (Parenthetical)       HTML     44K 
45: R4          Consolidated Statements of Comprehensive Loss       HTML     75K 
22: R5          Consolidated Statements of Mezzanine Equity         HTML     39K 
60: R6          Consolidated Statements of Mezzanine Equity -       HTML     25K 
                (Parenthetical)                                                  
66: R7          Consolidated Statements of Stockholders' Equity     HTML    102K 
                (Deficit)                                                        
47: R8          Consolidated Statements of Stockholders' Equity     HTML     29K 
                (Deficit) (Parenthetical)                                        
19: R9          Consolidated Statements of Cash Flows               HTML    134K 
72: R10         Nature of Operations and Summary of Significant     HTML    133K 
                Accounting Policies                                              
54: R11         Property and Equipment                              HTML     40K 
27: R12         Intangible Asset                                    HTML     30K 
35: R13         Commitments and Contingencies                       HTML     69K 
71: R14         Long-Term Debt                                      HTML     53K 
53: R15         Stockholders' Equity                                HTML    122K 
25: R16         Noncontrolling Interest                             HTML     29K 
34: R17         Income Taxes                                        HTML     55K 
73: R18         Employee Benefit Plan                               HTML     25K 
52: R19         Related Party Transactions                          HTML     30K 
24: R20         Nature of Operations and Summary of Significant     HTML    146K 
                Accounting Policies (Policies)                                   
46: R21         Nature of Operations and Summary of Significant     HTML     67K 
                Accounting Policies (Tables)                                     
68: R22         Property and Equipment (Tables)                     HTML     39K 
62: R23         Intangible Asset (Tables)                           HTML     28K 
21: R24         Commitments and Contingencies (Tables)              HTML     45K 
44: R25         Long-Term Debt (Tables)                             HTML     44K 
65: R26         Stockholders' Equity (Tables)                       HTML    104K 
59: R27         Income Taxes (Tables)                               HTML     52K 
20: R28         Nature of Operations and Summary of Significant     HTML    139K 
                Accounting Policies - Narrative (Details)                        
48: R29         Nature of Operations and Summary of Significant     HTML     29K 
                Accounting Policies - Revenue by Geographic Market               
                (Details)                                                        
37: R30         Nature of Operations and Summary of Significant     HTML     49K 
                Accounting Policies - Fair Value Hierarchy                       
                (Details)                                                        
28: R31         Property and Equipment - Summary (Details)          HTML     45K 
49: R32         Property and Equipment - Narrative (Details)        HTML     27K 
69: R33         Intangible Asset - Narrative (Details)              HTML     33K 
38: R34         Intangible Asset - Estimated Future Amortization    HTML     32K 
                Expense (Details)                                                
29: R35         Commitments and Contingencies - Narrative           HTML     73K 
                (Details)                                                        
50: R36         Commitments and Contingencies - Total Lease Cost    HTML     32K 
                (Details)                                                        
70: R37         Commitments and Contingencies - Future Minimum      HTML     46K 
                Lease Payments for Operating Lease (Details)                     
36: R38         Long-Term Debt - Narrative (Details)                HTML     73K 
30: R39         Long-Term Debt - Debt, Net of Unamortized Costs     HTML     36K 
                (Details)                                                        
42: R40         Long-Term Debt - Expected Future Principal          HTML     32K 
                Payments for Term Loan (Details)                                 
15: R41         Stockholders' Equity - Preferred Stock Narrative    HTML     37K 
                (Details)                                                        
57: R42         Stockholders' Equity - Stock-based Compensation     HTML     32K 
                Expense (Details)                                                
63: R43         Stockholders' Equity - Stock Option Narrative       HTML     45K 
                (Details)                                                        
43: R44         Stockholders' Equity - Common Stock Reserved for    HTML     40K 
                Future Issuance (Details)                                        
16: R45         Stockholders' Equity - Fair Value Assumptions       HTML     41K 
                (Details)                                                        
58: R46         Stockholders' Equity - Stock Option Activity        HTML     62K 
                (Details)                                                        
64: R47         Stockholders' Equity - Stock Subscriptions          HTML     31K 
                Receivable (Details)                                             
41: R48         Stockholders' Equity - Restricted Shares Award      HTML     30K 
                Narrative (Details)                                              
17: R49         Stockholders' Equity - Restricted Shares Awards     HTML     48K 
                Activity (Details)                                               
33: R50         Stockholders' Equity - Restricted Stock Units       HTML     29K 
                Narrative (Details)                                              
40: R51         Stockholders' Equity - Restricted Stock Units       HTML     37K 
                Activity (Details)                                               
75: R52         Stockholders' Equity - Stock Warrants (Details)     HTML     76K 
56: R53         Noncontrolling Interest - Narrative (Details)       HTML     30K 
32: R54         Income Taxes - Narrative (Details)                  HTML     34K 
39: R55         Income Taxes - Net Deferred Tax Assets (Details)    HTML     45K 
74: R56         Income Taxes - Effective Income Tax Rate            HTML     42K 
                Reconciliation (Details)                                         
55: R57         Employee Benefit Plan - Narrative (Details)         HTML     24K 
31: R58         Related Party Transactions - Narrative (Details)    HTML     35K 
18: XML         IDEA XML File -- Filing Summary                      XML    128K 
51: EXCEL       IDEA Workbook of Financial Reports                  XLSX     82K 
 9: EX-101.INS  XBRL Instance -- axnx-20191231                       XML   1.45M 
11: EX-101.CAL  XBRL Calculations -- axnx-20191231_cal               XML    203K 
12: EX-101.DEF  XBRL Definitions -- axnx-20191231_def                XML    625K 
13: EX-101.LAB  XBRL Labels -- axnx-20191231_lab                     XML   1.50M 
14: EX-101.PRE  XBRL Presentations -- axnx-20191231_pre              XML    925K 
10: EX-101.SCH  XBRL Schema -- axnx-20191231                         XSD    139K 
26: ZIP         XBRL Zipped Folder -- 0001603756-20-000013-xbrl      Zip    202K

‘EX-101.DEF’   —   XBRL Definitions — axnx-20191231_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<link:roleRef roleURI="http://axonicsmodulation.com/role/CommitmentsAndContingencies" xlink:href="axnx-20191231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/CommitmentsAndContingenciesFutureMinimumLeasePaymentsForOperatingLeaseDetails" xlink:href="axnx-20191231.xsd#CommitmentsAndContingenciesFutureMinimumLeasePaymentsForOperatingLeaseDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:href="axnx-20191231.xsd#CommitmentsAndContingenciesNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/CommitmentsAndContingenciesTables" xlink:href="axnx-20191231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/CommitmentsAndContingenciesTotalLeaseCostDetails" xlink:href="axnx-20191231.xsd#CommitmentsAndContingenciesTotalLeaseCostDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedBalanceSheets" xlink:href="axnx-20191231.xsd#ConsolidatedBalanceSheets" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="axnx-20191231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfComprehensiveLoss" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfMezzanineEquity" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfMezzanineEquity" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfMezzanineEquityParenthetical" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfMezzanineEquityParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/ConsolidatedStatementsOfStockholdersEquityDeficitParenthetical" xlink:href="axnx-20191231.xsd#ConsolidatedStatementsOfStockholdersEquityDeficitParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/CoverPage" xlink:href="axnx-20191231.xsd#CoverPage" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/EmployeeBenefitPlan" xlink:href="axnx-20191231.xsd#EmployeeBenefitPlan" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/EmployeeBenefitPlanNarrativeDetails" xlink:href="axnx-20191231.xsd#EmployeeBenefitPlanNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IncomeTaxes" xlink:href="axnx-20191231.xsd#IncomeTaxes" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails" xlink:href="axnx-20191231.xsd#IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IncomeTaxesNarrativeDetails" xlink:href="axnx-20191231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IncomeTaxesNetDeferredTaxAssetsDetails" xlink:href="axnx-20191231.xsd#IncomeTaxesNetDeferredTaxAssetsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IncomeTaxesTables" xlink:href="axnx-20191231.xsd#IncomeTaxesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IntangibleAsset" xlink:href="axnx-20191231.xsd#IntangibleAsset" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IntangibleAssetEstimatedFutureAmortizationExpenseDetails" xlink:href="axnx-20191231.xsd#IntangibleAssetEstimatedFutureAmortizationExpenseDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IntangibleAssetNarrativeDetails" xlink:href="axnx-20191231.xsd#IntangibleAssetNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/IntangibleAssetTables" xlink:href="axnx-20191231.xsd#IntangibleAssetTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/LongTermDebt" xlink:href="axnx-20191231.xsd#LongTermDebt" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/LongTermDebtDebtNetOfUnamortizedCostsDetails" xlink:href="axnx-20191231.xsd#LongTermDebtDebtNetOfUnamortizedCostsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/LongTermDebtExpectedFuturePrincipalPaymentsForTermLoanDetails" xlink:href="axnx-20191231.xsd#LongTermDebtExpectedFuturePrincipalPaymentsForTermLoanDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/LongTermDebtNarrativeDetails" xlink:href="axnx-20191231.xsd#LongTermDebtNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/LongTermDebtTables" xlink:href="axnx-20191231.xsd#LongTermDebtTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPolicies" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesFairValueHierarchyDetails" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesFairValueHierarchyDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesRevenueByGeographicMarketDetails" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesRevenueByGeographicMarketDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesTables" xlink:href="axnx-20191231.xsd#NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NoncontrollingInterest" xlink:href="axnx-20191231.xsd#NoncontrollingInterest" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/NoncontrollingInterestNarrativeDetails" xlink:href="axnx-20191231.xsd#NoncontrollingInterestNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/PropertyAndEquipment" xlink:href="axnx-20191231.xsd#PropertyAndEquipment" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/PropertyAndEquipmentNarrativeDetails" xlink:href="axnx-20191231.xsd#PropertyAndEquipmentNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/PropertyAndEquipmentSummaryDetails" xlink:href="axnx-20191231.xsd#PropertyAndEquipmentSummaryDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/PropertyAndEquipmentTables" xlink:href="axnx-20191231.xsd#PropertyAndEquipmentTables" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/RelatedPartyTransactions" xlink:href="axnx-20191231.xsd#RelatedPartyTransactions" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:href="axnx-20191231.xsd#RelatedPartyTransactionsNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquity" xlink:href="axnx-20191231.xsd#StockholdersEquity" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityCommonStockReservedForFutureIssuanceDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityCommonStockReservedForFutureIssuanceDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityFairValueAssumptionsDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityFairValueAssumptionsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityPreferredStockNarrativeDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityPreferredStockNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityRestrictedSharesAwardNarrativeDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityRestrictedSharesAwardNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityRestrictedSharesAwardsActivityDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityRestrictedSharesAwardsActivityDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityRestrictedStockUnitsActivityDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityRestrictedStockUnitsActivityDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityRestrictedStockUnitsNarrativeDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityRestrictedStockUnitsNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityStockBasedCompensationExpenseDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityStockBasedCompensationExpenseDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityStockOptionActivityDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityStockOptionActivityDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityStockOptionNarrativeDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityStockOptionNarrativeDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityStockSubscriptionsReceivableDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityStockSubscriptionsReceivableDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityStockWarrantsDetails" xlink:href="axnx-20191231.xsd#StockholdersEquityStockWarrantsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://axonicsmodulation.com/role/StockholdersEquityTables" xlink:href="axnx-20191231.xsd#StockholdersEquityTables" xlink:type="simple"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CommitmentsAndContingencies" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CommitmentsAndContingenciesFutureMinimumLeasePaymentsForOperatingLeaseDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_8BBC1D447043520201CDA289AADFF23C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_LossContingenciesTable_8BBC1D447043520201CDA289AADFF23C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseArrangementTypeAxis" xlink:label="loc_us-gaap_LeaseArrangementTypeAxis_EA6A21D3FD1D982ADCC0A289AAE00ECD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_8BBC1D447043520201CDA289AADFF23C" xlink:to="loc_us-gaap_LeaseArrangementTypeAxis_EA6A21D3FD1D982ADCC0A289AAE00ECD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseArrangementTypeDomain" xlink:label="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseArrangementTypeAxis_EA6A21D3FD1D982ADCC0A289AAE00ECD" xlink:to="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseArrangementTypeDomain" xlink:label="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseArrangementTypeAxis_EA6A21D3FD1D982ADCC0A289AAE00ECD" xlink:to="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_Lease1Member" xlink:label="loc_axnx_Lease1Member_78423E1686E1AEEB5847A289AAE028C9" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466" xlink:to="loc_axnx_Lease1Member_78423E1686E1AEEB5847A289AAE028C9" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_Lease2Member" xlink:label="loc_axnx_Lease2Member_928A7AA61A85802C30EAA289AAE00EDF" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466" xlink:to="loc_axnx_Lease2Member_928A7AA61A85802C30EAA289AAE00EDF" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_Lease3Member" xlink:label="loc_axnx_Lease3Member_C9E9CBCDB868273EFDA0A289AAE16059" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseArrangementTypeDomain_C865A5C50569867215ADA289AAE0B466" xlink:to="loc_axnx_Lease3Member_C9E9CBCDB868273EFDA0A289AAE16059" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_EAB7CB5DE15F3B7F84F3A289AAE182B7" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_8BBC1D447043520201CDA289AADFF23C" xlink:to="loc_srt_RangeAxis_EAB7CB5DE15F3B7F84F3A289AAE182B7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_E1B2464507A099096466A289AAE1BFB2_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_EAB7CB5DE15F3B7F84F3A289AAE182B7" xlink:to="loc_srt_RangeMember_E1B2464507A099096466A289AAE1BFB2_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_E1B2464507A099096466A289AAE1BFB2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_EAB7CB5DE15F3B7F84F3A289AAE182B7" xlink:to="loc_srt_RangeMember_E1B2464507A099096466A289AAE1BFB2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_AAD0CA686639BABA7504A289AAE1925C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_E1B2464507A099096466A289AAE1BFB2" xlink:to="loc_srt_MaximumMember_AAD0CA686639BABA7504A289AAE1925C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_5B56DB4015B52A614541A289AAE7C8E1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_5B56DB4015B52A614541A289AAE7C8E1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetRentableArea" xlink:label="loc_us-gaap_NetRentableArea_B1681B75DD41D7305C60A289AAE71C9D" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_NetRentableArea_B1681B75DD41D7305C60A289AAE71C9D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_2CD7633F271A7A34B293A289AAE75DB1" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_2CD7633F271A7A34B293A289AAE75DB1" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_LesseeOperatingLeaseBaseRent" xlink:label="loc_axnx_LesseeOperatingLeaseBaseRent_F427767A2C4380BDBB34A289AAE74815" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_LesseeOperatingLeaseBaseRent_F427767A2C4380BDBB34A289AAE74815" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_OperatingLeasesAdditionalRentDue" xlink:label="loc_axnx_OperatingLeasesAdditionalRentDue_B3D4432A3686FDBAB6BEA289AAE78383" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_OperatingLeasesAdditionalRentDue_B3D4432A3686FDBAB6BEA289AAE78383" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PaymentsForLeaseholdImprovementsNetOfTenantAllowances" xlink:label="loc_axnx_PaymentsForLeaseholdImprovementsNetOfTenantAllowances_D0D705803EA4D0D641BBA289AAE82D77" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_PaymentsForLeaseholdImprovementsNetOfTenantAllowances_D0D705803EA4D0D641BBA289AAE82D77" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromTenantAllowance" xlink:label="loc_us-gaap_PaymentsForProceedsFromTenantAllowance_9DF2996A7D19EF5C5800A289AAE8C662" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_PaymentsForProceedsFromTenantAllowance_9DF2996A7D19EF5C5800A289AAE8C662" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_7A05935B7E1129EEF8B4A289AAE8D293" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_7A05935B7E1129EEF8B4A289AAE8D293" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_6F0101192CF545006711A289AAE8E799" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_6F0101192CF545006711A289AAE8E799" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasePayments" xlink:label="loc_us-gaap_OperatingLeasePayments_C81D2CF0C0F6C79A3F74A289AAE8374A" xlink:type="locator"/>
<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_OperatingLeasePayments_C81D2CF0C0F6C79A3F74A289AAE8374A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_OperatingLeaseRightofUseAssetAmortization" xlink:label="loc_axnx_OperatingLeaseRightofUseAssetAmortization_FEA64C52DBCBED616634A289AAE869B4" xlink:type="locator"/>
<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_OperatingLeaseRightofUseAssetAmortization_FEA64C52DBCBED616634A289AAE869B4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseDiscountRate" xlink:label="loc_us-gaap_LesseeOperatingLeaseDiscountRate_4EDC0F614A1EE7944388A289AAE9BA5A" xlink:type="locator"/>
<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_LesseeOperatingLeaseDiscountRate_4EDC0F614A1EE7944388A289AAE9BA5A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PeriodAfterFirstSaleRoyaltyIsDue" xlink:label="loc_axnx_PeriodAfterFirstSaleRoyaltyIsDue_85C0AA701527C3E96DFFA289AAE9ABDB" xlink:type="locator"/>
<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_PeriodAfterFirstSaleRoyaltyIsDue_85C0AA701527C3E96DFFA289AAE9ABDB" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PercentageofNetRevenueDueAsRoyalty" xlink:label="loc_axnx_PercentageofNetRevenueDueAsRoyalty_1FC9810E7572B7A04F41A289AAE972F8" xlink:type="locator"/>
<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_axnx_PercentageofNetRevenueDueAsRoyalty_1FC9810E7572B7A04F41A289AAE972F8" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyGuaranteesCommitmentsAmount" xlink:label="loc_us-gaap_RoyaltyGuaranteesCommitmentsAmount_B26D9FC26D42F3F855B8A289AAE9853C" xlink:type="locator"/>
<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_RoyaltyGuaranteesCommitmentsAmount_B26D9FC26D42F3F855B8A289AAE9853C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_961639F5B4079EF3FF59A289AAE9E179" xlink:type="locator"/>
<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_961639F5B4079EF3FF59A289AAE9E179" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyExpense" xlink:label="loc_us-gaap_RoyaltyExpense_39E40131E026FF9957F4A289AAE98912" xlink:type="locator"/>
<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_69CA3E4B926229C79DE6A289AAE68B25" xlink:to="loc_us-gaap_RoyaltyExpense_39E40131E026FF9957F4A289AAE98912" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CommitmentsAndContingenciesTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CommitmentsAndContingenciesTotalLeaseCostDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedBalanceSheets" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_E27E137CDD6C9D25C152A289AC02D94C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_StatementTable_E27E137CDD6C9D25C152A289AC02D94C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_AD1C3EE49E1259B1078DA289AC0218E6" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_E27E137CDD6C9D25C152A289AC02D94C" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_AD1C3EE49E1259B1078DA289AC0218E6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_AD1C3EE49E1259B1078DA289AC0218E6" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_AD1C3EE49E1259B1078DA289AC0218E6" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_FollowonOfferingMember" xlink:label="loc_axnx_FollowonOfferingMember_FC8B09E7630866CF4464A289AC03CB6A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68" xlink:to="loc_axnx_FollowonOfferingMember_FC8B09E7630866CF4464A289AC03CB6A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IPOMember" xlink:label="loc_us-gaap_IPOMember_E661FAC83556B6A5B21CA289AC03FBE0" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_51EA25B9F5C43460945DA289AC03EC68" xlink:to="loc_us-gaap_IPOMember_E661FAC83556B6A5B21CA289AC03FBE0" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_116A93EAA68BE5ABBCBFA289AC03BC98" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_E27E137CDD6C9D25C152A289AC02D94C" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_116A93EAA68BE5ABBCBFA289AC03BC98" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_116A93EAA68BE5ABBCBFA289AC03BC98" xlink:to="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_116A93EAA68BE5ABBCBFA289AC03BC98" xlink:to="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_FE6DD84534E808CECD65A289AC04E938" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1" xlink:to="loc_us-gaap_CommonStockMember_FE6DD84534E808CECD65A289AC04E938" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_4B592E6AB15E648B2B95A289AC042B63" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8EE186CE17FB74B699F8A289AC0462B1" xlink:to="loc_us-gaap_PreferredStockMember_4B592E6AB15E648B2B95A289AC042B63" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_70D2D65463AA1B2B0A52A289AC055D7B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_70D2D65463AA1B2B0A52A289AC055D7B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_67D7DA2ED86A9E05E67FA289AC05ADEB" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_70D2D65463AA1B2B0A52A289AC055D7B" xlink:to="loc_us-gaap_ProfitLoss_67D7DA2ED86A9E05E67FA289AC05ADEB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_70D2D65463AA1B2B0A52A289AC055D7B" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_758015D8F4210BED5416A289AC0528F5" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_758015D8F4210BED5416A289AC0528F5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_8B1ED28F0CCAA72ADF0FA289AC06E814" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_ShareBasedCompensation_8B1ED28F0CCAA72ADF0FA289AC06E814" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_9C881AC4F3CD2554283CA289AC06AE32" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_9C881AC4F3CD2554283CA289AC06AE32" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_4376A45272396ECE6160A289AC067E47" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_4376A45272396ECE6160A289AC067E47" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ForgivenessofStockSubscriptionReceivable" xlink:label="loc_axnx_ForgivenessofStockSubscriptionReceivable_60E3D2005CE60E704BEBA289AC068BAA" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_axnx_ForgivenessofStockSubscriptionReceivable_60E3D2005CE60E704BEBA289AC068BAA" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_7E7DFAB6E5FDB18E4445A289AC06E979" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_7E7DFAB6E5FDB18E4445A289AC06E979" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_135D585B6AA4935952E6A289AC0533C6" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_7B020FBC9F3924BF5456A289AC07B3BD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_7B020FBC9F3924BF5456A289AC07B3BD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_3B527AFF55F0D30F83AAA289AC0791E2" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_3B527AFF55F0D30F83AAA289AC0791E2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_59D6831D382140588936A289AC07C7CF" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_59D6831D382140588936A289AC07C7CF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_1DA29343865D68A4031AA289AC07B541" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_1DA29343865D68A4031AA289AC07B541" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_F37BEAB458B52B437A86A289AC08E08B" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_F37BEAB458B52B437A86A289AC08E08B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_C990EBE12914B79D7D1EA289AC08DC19" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_C990EBE12914B79D7D1EA289AC08DC19" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_3DD54618E8F94C545401A289AC0893BF" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_3DD54618E8F94C545401A289AC0893BF" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_IncreaseDecreaseinLeaseLiabilities" xlink:label="loc_axnx_IncreaseDecreaseinLeaseLiabilities_436FBA579560FABD096CA289AC08AF55" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_6DFE1F8B35A30F44B9E3A289AC06B1FA" xlink:to="loc_axnx_IncreaseDecreaseinLeaseLiabilities_436FBA579560FABD096CA289AC08AF55" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_66EC05CC15A4D0606BF9A289AC08C8D9" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_70D2D65463AA1B2B0A52A289AC055D7B" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_66EC05CC15A4D0606BF9A289AC08C8D9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5C862F45855971013260A289AC089CD1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5C862F45855971013260A289AC089CD1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_E9EFED2E51A274655810A289AC09CCE9" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_E9EFED2E51A274655810A289AC09CCE9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_1245FCEB864DBE166EF9A289AC09343C" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_1245FCEB864DBE166EF9A289AC09343C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ADEE7779A4505A1BA67DA289AC095D5D" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_CD16A9989E80B0FCC5A7A289AC08688E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ADEE7779A4505A1BA67DA289AC095D5D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_BE00BC7FD26E1E99C035A289AC0921CC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_BE00BC7FD26E1E99C035A289AC0921CC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7D2598ABDBD6BEE7B3B4A289AC0A0B48" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7D2598ABDBD6BEE7B3B4A289AC0A0B48" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_2972853042EAEB24EB9FA289AC0A10EF" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_2972853042EAEB24EB9FA289AC0A10EF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_29AF16CD66D6D50AEFD5A289AC0A8DE3" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_29AF16CD66D6D50AEFD5A289AC0A8DE3" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_BC2CBF4DCDA0EB3D0860A289AC0A60A3" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_BC2CBF4DCDA0EB3D0860A289AC0A60A3" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ProceedsFromIssuanceOfPreferredStockAndPreferenceStockAndNoncontrollingInterest" xlink:label="loc_axnx_ProceedsFromIssuanceOfPreferredStockAndPreferenceStockAndNoncontrollingInterest_4E63872E81DDFA1B59CAA289AC0A0D06" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_axnx_ProceedsFromIssuanceOfPreferredStockAndPreferenceStockAndNoncontrollingInterest_4E63872E81DDFA1B59CAA289AC0A0D06" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_BCE64114B22DA639DD84A289AC0AF5E6" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_BCE64114B22DA639DD84A289AC0AF5E6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0BC3597326A4FE05AF45A289AC0B343A" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_AE590FB2017DDFC53F3EA289AC094104" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0BC3597326A4FE05AF45A289AC0B343A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_588416E7136B80B28D21A289AC0B66A6" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_588416E7136B80B28D21A289AC0B66A6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7B17B77C0FDC09E543E4A289AC0BB15F" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7B17B77C0FDC09E543E4A289AC0BB15F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0FBFC84E00AB69252182A289AC0B49B7" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0FBFC84E00AB69252182A289AC0B49B7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SupplementalCashFlowElementsAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowElementsAbstract_2F69C822E54F7CCB04FFA289AC0B409B" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_SupplementalCashFlowElementsAbstract_2F69C822E54F7CCB04FFA289AC0B409B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_C6DF3273C2B1DD91A881A289AC0CDB53" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowElementsAbstract_2F69C822E54F7CCB04FFA289AC0B409B" xlink:to="loc_us-gaap_InterestPaidNet_C6DF3273C2B1DD91A881A289AC0CDB53" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_0AC41E683D7F8CF078D1A289AC0CD48B" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowElementsAbstract_2F69C822E54F7CCB04FFA289AC0B409B" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_0AC41E683D7F8CF078D1A289AC0CD48B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_13120B6FFC0A37125DECA289AC0C0735" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_D7A56E5F92DBE37F66A7A289AC04F4D1" xlink:to="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_13120B6FFC0A37125DECA289AC0C0735" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_53EABE6BC2CB5CBD775EA289AC0C4707" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_13120B6FFC0A37125DECA289AC0C0735" xlink:to="loc_us-gaap_StockIssued1_53EABE6BC2CB5CBD775EA289AC0C4707" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_WarrantsIssuedDebtIssuanceCosts" xlink:label="loc_axnx_WarrantsIssuedDebtIssuanceCosts_E5573CBE32D3A26AB23EA289AC0C2899" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_13120B6FFC0A37125DECA289AC0C0735" xlink:to="loc_axnx_WarrantsIssuedDebtIssuanceCosts_E5573CBE32D3A26AB23EA289AC0C2899" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_AccruedLoanFeesDebtIssuanceCosts" xlink:label="loc_axnx_AccruedLoanFeesDebtIssuanceCosts_E26A6D202BD429043FDCA289AC0DD69F" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_13120B6FFC0A37125DECA289AC0C0735" xlink:to="loc_axnx_AccruedLoanFeesDebtIssuanceCosts_E26A6D202BD429043FDCA289AC0DD69F" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfMezzanineEquity" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_2D1B342D8D3E48950227676FA104DD8F" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_C88A368F5CCE996AD669676FA0FFDBAD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_2D1B342D8D3E48950227676FA104DD8F" xlink:to="loc_us-gaap_StatementTable_C88A368F5CCE996AD669676FA0FFDBAD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_26CD72F7FD2667B6BCC4676FA1007B12" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_C88A368F5CCE996AD669676FA0FFDBAD" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_26CD72F7FD2667B6BCC4676FA1007B12" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_26CD72F7FD2667B6BCC4676FA1007B12" xlink:to="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_26CD72F7FD2667B6BCC4676FA1007B12" xlink:to="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_F7BE2DF0B48EF78476D4676FA1003BC1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8" xlink:to="loc_us-gaap_PreferredStockMember_F7BE2DF0B48EF78476D4676FA1003BC1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_C2652C2B0114E3493347676FA101C6BB" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_66C548A697D4766BC994676FA100BEA8" xlink:to="loc_us-gaap_NoncontrollingInterestMember_C2652C2B0114E3493347676FA101C6BB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_B8D01095FB4F23BBB350676FA1027EBE" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_C88A368F5CCE996AD669676FA0FFDBAD" xlink:to="loc_us-gaap_StatementClassOfStockAxis_B8D01095FB4F23BBB350676FA1027EBE" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_B8D01095FB4F23BBB350676FA1027EBE" xlink:to="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_B8D01095FB4F23BBB350676FA1027EBE" xlink:to="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_1C6EC8EF99D283473738676FA102E297" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_1C6EC8EF99D283473738676FA102E297" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SeriesB1PreferredStockMember" xlink:label="loc_axnx_SeriesB1PreferredStockMember_9A0CAEE8FC5EFCB485F1676FA103A37F" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:to="loc_axnx_SeriesB1PreferredStockMember_9A0CAEE8FC5EFCB485F1676FA103A37F" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SeriesB2PreferredStockMember" xlink:label="loc_axnx_SeriesB2PreferredStockMember_6B23A07635030B72664E676FA103DDC3" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:to="loc_axnx_SeriesB2PreferredStockMember_6B23A07635030B72664E676FA103DDC3" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_E8092025BDE84B3FB60C676FA1031A5D" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_00D47446E4B61DDE44B3676FA10258B2" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_E8092025BDE84B3FB60C676FA1031A5D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_2D1B342D8D3E48950227676FA104DD8F" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_A5F8CA6CAA8B6E794662676FA10446E7" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_A5F8CA6CAA8B6E794662676FA10446E7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_77564B7936D3C1BF010B676FA1043921" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_77564B7936D3C1BF010B676FA1043921" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_axnx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues_DB47FCE306614491093A676FA1057482" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_axnx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues_DB47FCE306614491093A676FA1057482" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_456A39CC1B3E1603F6D8676FA105AE4C" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_456A39CC1B3E1603F6D8676FA105AE4C" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStockSharesConverted" xlink:label="loc_axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStockSharesConverted_89404D9E8FB179061876676FA106758A" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStockSharesConverted_89404D9E8FB179061876676FA106758A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStock" xlink:label="loc_axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStock_5B9AA435FADAE209C089676FA106A366" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0A60C127A0A73228ECEA676FA10421B8" xlink:to="loc_axnx_TemporaryEquityInitialPublicOfferingConversionofPreferredStocktoCommonStock_5B9AA435FADAE209C089676FA106A366" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfMezzanineEquityParenthetical" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_CC780825EA835947CB5E72AAFDEA1C37" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_3D472937ECFF214C36E772AAFDE9C120" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_CC780825EA835947CB5E72AAFDEA1C37" xlink:to="loc_us-gaap_StatementTable_3D472937ECFF214C36E772AAFDE9C120" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_C0FD52F886D358FA545172AAFDE9AA62" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_3D472937ECFF214C36E772AAFDE9C120" xlink:to="loc_us-gaap_StatementClassOfStockAxis_C0FD52F886D358FA545172AAFDE9AA62" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_486186C3E41A92DA4D4D72AAFDEAA139_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_C0FD52F886D358FA545172AAFDE9AA62" xlink:to="loc_us-gaap_ClassOfStockDomain_486186C3E41A92DA4D4D72AAFDEAA139_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_486186C3E41A92DA4D4D72AAFDEAA139" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_C0FD52F886D358FA545172AAFDE9AA62" xlink:to="loc_us-gaap_ClassOfStockDomain_486186C3E41A92DA4D4D72AAFDEAA139" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_6961BF3D402AEB3CD78072AAFDEAF847" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_486186C3E41A92DA4D4D72AAFDEAA139" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_6961BF3D402AEB3CD78072AAFDEAF847" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_E13B80FDF357E4CA87EC72AAFDEA2B93" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_CC780825EA835947CB5E72AAFDEA1C37" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_E13B80FDF357E4CA87EC72AAFDEA2B93" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_2BA25E48734A23F123D672AAFDEBDFA6" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_CC780825EA835947CB5E72AAFDEA1C37" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_2BA25E48734A23F123D672AAFDEBDFA6" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_89943CD527540A806219A28890C68889" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_9BAFEB4A542AE48066A2A28890C31F10" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_89943CD527540A806219A28890C68889" xlink:to="loc_us-gaap_StatementTable_9BAFEB4A542AE48066A2A28890C31F10" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_545B89D8EEAAE5DC1498A28890C3C2F5" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9BAFEB4A542AE48066A2A28890C31F10" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_545B89D8EEAAE5DC1498A28890C3C2F5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_545B89D8EEAAE5DC1498A28890C3C2F5" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_545B89D8EEAAE5DC1498A28890C3C2F5" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IPOMember" xlink:label="loc_us-gaap_IPOMember_2CC08F7C0DE3B734BF04A28890C4FE7A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113" xlink:to="loc_us-gaap_IPOMember_2CC08F7C0DE3B734BF04A28890C4FE7A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_FollowonOfferingMember" xlink:label="loc_axnx_FollowonOfferingMember_DEF610CCC6D95090344EA28890C4C6DF" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_80C58FC4EC44D72AF039A28890C3C113" xlink:to="loc_axnx_FollowonOfferingMember_DEF610CCC6D95090344EA28890C4C6DF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_9CD800F320078DBE8E37A28890C4148E" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9BAFEB4A542AE48066A2A28890C31F10" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_9CD800F320078DBE8E37A28890C4148E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9CD800F320078DBE8E37A28890C4148E" xlink:to="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9CD800F320078DBE8E37A28890C4148E" xlink:to="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_7EF3C48F1E773DBD0316A28890C5DD48" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:to="loc_us-gaap_CommonStockMember_7EF3C48F1E773DBD0316A28890C5DD48" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_633E3C20793EA69D5279A28890C56547" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_633E3C20793EA69D5279A28890C56547" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReceivablesFromStockholderMember" xlink:label="loc_us-gaap_ReceivablesFromStockholderMember_52467BACA420812F30FDA28890C5D3F0" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:to="loc_us-gaap_ReceivablesFromStockholderMember_52467BACA420812F30FDA28890C5D3F0" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_FAFFEBEF1C38479DA3F4A28890C5FE09" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:to="loc_us-gaap_RetainedEarningsMember_FAFFEBEF1C38479DA3F4A28890C5FE09" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2E5EDC51D953D0DED8A8A28890C68C5A" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D15C0A9C6FECD9134331A28890C4B9B1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2E5EDC51D953D0DED8A8A28890C68C5A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_89943CD527540A806219A28890C68889" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_2805B8C125495DC6AB10A28890C61511" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_2805B8C125495DC6AB10A28890C61511" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_2F2A22346CA51CBFC7F0A28890C6F6C2" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockholdersEquity_2F2A22346CA51CBFC7F0A28890C6F6C2" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodNotesReceivable" xlink:label="loc_axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodNotesReceivable_C69D00E6EC451D38B8F6A28890C76DE6" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodNotesReceivable_C69D00E6EC451D38B8F6A28890C76DE6" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_StockIssuedDuringPeriodValueStockOptionsExercisedNotesReceivable" xlink:label="loc_axnx_StockIssuedDuringPeriodValueStockOptionsExercisedNotesReceivable_182DCE2643CA874DAE31A28890C75AD6" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_StockIssuedDuringPeriodValueStockOptionsExercisedNotesReceivable_182DCE2643CA874DAE31A28890C75AD6" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodCash" xlink:label="loc_axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodCash_13ABFADE4CEA7735A03CA28890C7AEBA" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisesInPeriodCash_13ABFADE4CEA7735A03CA28890C7AEBA" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_StockIssuedDuringPeriodValueStockOptionsExercisedCash" xlink:label="loc_axnx_StockIssuedDuringPeriodValueStockOptionsExercisedCash_76C40CD10C622E757A14A28890C7F9DC" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_StockIssuedDuringPeriodValueStockOptionsExercisedCash_76C40CD10C622E757A14A28890C7F9DC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_781D493EBD79A6228760A28890C731C7" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_781D493EBD79A6228760A28890C731C7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_F2C4C5D8C6D9B5A5DD1DA28890C8D369" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_F2C4C5D8C6D9B5A5DD1DA28890C8D369" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_4BC8F1EE55695FBF6F54A28890C8D67E" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_4BC8F1EE55695FBF6F54A28890C8D67E" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_LoanForgivenessofStockSubscriptionReceivable" xlink:label="loc_axnx_LoanForgivenessofStockSubscriptionReceivable_2C1FE39FA20ACC60DC1CA28890C8D98F" xlink:type="locator"/>
<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_LoanForgivenessofStockSubscriptionReceivable_2C1FE39FA20ACC60DC1CA28890C8D98F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_C5EC4E0D9FC9B5849A6FA28890C849F7" xlink:type="locator"/>
<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_C5EC4E0D9FC9B5849A6FA28890C849F7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_7CD8149B51DD9D8A67B7A28890C938E4" xlink:type="locator"/>
<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_7CD8149B51DD9D8A67B7A28890C938E4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_FDE19D03FE16A5D2CEF6A2902A0D5D15" xlink:type="locator"/>
<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_FDE19D03FE16A5D2CEF6A2902A0D5D15" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_C75203F9DCBB8665D915A28890CAE191" xlink:type="locator"/>
<link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_C75203F9DCBB8665D915A28890CAE191" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition_7B2AACAF71FB3FB6C912A28890C9DFF5" xlink:type="locator"/>
<link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition_7B2AACAF71FB3FB6C912A28890C9DFF5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_13D927930937577DA2C3A28890C9EDBB" xlink:type="locator"/>
<link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_13D927930937577DA2C3A28890C9EDBB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_D265644F4979AB610106A28890C936A2" xlink:type="locator"/>
<link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_D265644F4979AB610106A28890C936A2" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_StockIssuedDuringPeriodSharesExerciseofWarrants" xlink:label="loc_axnx_StockIssuedDuringPeriodSharesExerciseofWarrants_43DE31E91C7AD3075174A28890CAC062" xlink:type="locator"/>
<link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_axnx_StockIssuedDuringPeriodSharesExerciseofWarrants_43DE31E91C7AD3075174A28890CAC062" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_00517483595BD26294CFA28890CA62D2" xlink:type="locator"/>
<link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_00517483595BD26294CFA28890CA62D2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_CCBFDDAFCD2463577960A28890CAFAE0" xlink:type="locator"/>
<link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5F43EC8F3A9798C670D3A28890C68692" xlink:to="loc_us-gaap_NetIncomeLoss_CCBFDDAFCD2463577960A28890CAFAE0" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/ConsolidatedStatementsOfStockholdersEquityDeficitParenthetical" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_72CFF69666663F3DF509A2889101DCE5" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_25301B816C257CF01B5AA28890FF04E3" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_72CFF69666663F3DF509A2889101DCE5" xlink:to="loc_us-gaap_StatementTable_25301B816C257CF01B5AA28890FF04E3" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_62E8A2ECE3B2982A701EA288910068A2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_25301B816C257CF01B5AA28890FF04E3" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_62E8A2ECE3B2982A701EA288910068A2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_62E8A2ECE3B2982A701EA288910068A2" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_62E8A2ECE3B2982A701EA288910068A2" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IPOMember" xlink:label="loc_us-gaap_IPOMember_ADE8689D6DA50D9DF9B5A28891005550" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086" xlink:to="loc_us-gaap_IPOMember_ADE8689D6DA50D9DF9B5A28891005550" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_FollowonOfferingMember" xlink:label="loc_axnx_FollowonOfferingMember_EE9BBB64F93EDC79CD1CA2889100E66F" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_01E2795F75694828BFDFA28891009086" xlink:to="loc_axnx_FollowonOfferingMember_EE9BBB64F93EDC79CD1CA2889100E66F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_8BDC7038C55DE603AD4AA2889100E84D" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_25301B816C257CF01B5AA28890FF04E3" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_8BDC7038C55DE603AD4AA2889100E84D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_751E0DBBC7B36529C3D4A2889101CA13_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8BDC7038C55DE603AD4AA2889100E84D" xlink:to="loc_us-gaap_EquityComponentDomain_751E0DBBC7B36529C3D4A2889101CA13_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_751E0DBBC7B36529C3D4A2889101CA13" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8BDC7038C55DE603AD4AA2889100E84D" xlink:to="loc_us-gaap_EquityComponentDomain_751E0DBBC7B36529C3D4A2889101CA13" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_BEE230B1A3B34FB7E6FEA28891012E4C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_751E0DBBC7B36529C3D4A2889101CA13" xlink:to="loc_us-gaap_CommonStockMember_BEE230B1A3B34FB7E6FEA28891012E4C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_3018B56BD071DC9BF458A28891017A85" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_72CFF69666663F3DF509A2889101DCE5" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_3018B56BD071DC9BF458A28891017A85" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_3EA341A64EEEDBD1624BA28891021B4A" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_72CFF69666663F3DF509A2889101DCE5" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_3EA341A64EEEDBD1624BA28891021B4A" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/CoverPage" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/EmployeeBenefitPlan" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/EmployeeBenefitPlanNarrativeDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IncomeTaxes" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxContingencyLineItems" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_AF0357D86079437B4AAA787299B6606D" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxContingencyTable" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_C93757DEEFDBD900AC29787299B4C9E5" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_AF0357D86079437B4AAA787299B6606D" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_C93757DEEFDBD900AC29787299B4C9E5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_A3425D103B7B198F2D22787299B47E7E" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_C93757DEEFDBD900AC29787299B4C9E5" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_A3425D103B7B198F2D22787299B47E7E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_26048C6AD93C8011DB78787299B55F9F_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_A3425D103B7B198F2D22787299B47E7E" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_26048C6AD93C8011DB78787299B55F9F_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_26048C6AD93C8011DB78787299B55F9F" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_A3425D103B7B198F2D22787299B47E7E" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_26048C6AD93C8011DB78787299B55F9F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchMember" xlink:label="loc_us-gaap_ResearchMember_6CD369965C60B97D2217787299B5F8FE" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_26048C6AD93C8011DB78787299B55F9F" xlink:to="loc_us-gaap_ResearchMember_6CD369965C60B97D2217787299B5F8FE" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_2693A40DAFFA73D555E5787299B629B4" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_C93757DEEFDBD900AC29787299B4C9E5" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_2693A40DAFFA73D555E5787299B629B4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1D50C2BF583546E03BF7787299B6A8BB_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2693A40DAFFA73D555E5787299B629B4" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1D50C2BF583546E03BF7787299B6A8BB_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1D50C2BF583546E03BF7787299B6A8BB" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2693A40DAFFA73D555E5787299B629B4" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1D50C2BF583546E03BF7787299B6A8BB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_DD487F2EC1F3915F4CBA787299B6244A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_1D50C2BF583546E03BF7787299B6A8BB" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_DD487F2EC1F3915F4CBA787299B6244A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_3F12D9CC9E3AEDFCBD0B787299B77B67" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_AF0357D86079437B4AAA787299B6606D" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_3F12D9CC9E3AEDFCBD0B787299B77B67" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_093A9CFAD596794CDAC8787299B7548B" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_AF0357D86079437B4AAA787299B6606D" xlink:to="loc_us-gaap_OperatingLossCarryforwards_093A9CFAD596794CDAC8787299B7548B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_C6EA908C2C63013411C9787299B733CF" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_AF0357D86079437B4AAA787299B6606D" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_C6EA908C2C63013411C9787299B733CF" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IncomeTaxesNetDeferredTaxAssetsDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IncomeTaxesTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IntangibleAsset" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IntangibleAssetEstimatedFutureAmortizationExpenseDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IntangibleAssetNarrativeDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/IntangibleAssetTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/LongTermDebt" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/LongTermDebtDebtNetOfUnamortizedCostsDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/LongTermDebtExpectedFuturePrincipalPaymentsForTermLoanDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/LongTermDebtNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_BDAC74F7B2187412A72EA289AA958184" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_BDAC74F7B2187412A72EA289AA958184" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1ED6E96BEDB5B1C36F85A289AA959EE4_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_BDAC74F7B2187412A72EA289AA958184" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1ED6E96BEDB5B1C36F85A289AA959EE4_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1ED6E96BEDB5B1C36F85A289AA959EE4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_BDAC74F7B2187412A72EA289AA958184" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1ED6E96BEDB5B1C36F85A289AA959EE4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LoansPayableMember" xlink:label="loc_us-gaap_LoansPayableMember_26B017081E82801FFBEBA289AA96E157" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1ED6E96BEDB5B1C36F85A289AA959EE4" xlink:to="loc_us-gaap_LoansPayableMember_26B017081E82801FFBEBA289AA96E157" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_1DE5D6CF8D8E3BC764BDA289AA96B191" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:to="loc_us-gaap_DebtInstrumentAxis_1DE5D6CF8D8E3BC764BDA289AA96B191" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_1DE5D6CF8D8E3BC764BDA289AA96B191" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_1DE5D6CF8D8E3BC764BDA289AA96B191" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanMember" xlink:label="loc_axnx_TermLoanMember_1981D3AA6718BAEF1FDBA289AA96E630" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:to="loc_axnx_TermLoanMember_1981D3AA6718BAEF1FDBA289AA96E630" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanTrancheAMember" xlink:label="loc_axnx_TermLoanTrancheAMember_1626DBC283CA187A47F3A289AA979A7F" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:to="loc_axnx_TermLoanTrancheAMember_1626DBC283CA187A47F3A289AA979A7F" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanTrancheBCMember" xlink:label="loc_axnx_TermLoanTrancheBCMember_F069E8A7ADDED43BFA6EA289AA97F6B1" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:to="loc_axnx_TermLoanTrancheBCMember_F069E8A7ADDED43BFA6EA289AA97F6B1" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanTrancheBMember" xlink:label="loc_axnx_TermLoanTrancheBMember_A02F6DD5B6B0C3805D62A289AA97F656" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_TermLoanTrancheBCMember_F069E8A7ADDED43BFA6EA289AA97F6B1" xlink:to="loc_axnx_TermLoanTrancheBMember_A02F6DD5B6B0C3805D62A289AA97F656" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanTrancheCMember" xlink:label="loc_axnx_TermLoanTrancheCMember_E5384DA62ACEE53919DAA289AA9701EE" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_TermLoanTrancheBCMember_F069E8A7ADDED43BFA6EA289AA97F6B1" xlink:to="loc_axnx_TermLoanTrancheCMember_E5384DA62ACEE53919DAA289AA9701EE" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SecondAmendmenttotheLoanAgreementMember" xlink:label="loc_axnx_SecondAmendmenttotheLoanAgreementMember_0E4ABA006DCAC06F1FF7A289AA9713F5" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_96794E468EFC74FABF1EA289AA964588" xlink:to="loc_axnx_SecondAmendmenttotheLoanAgreementMember_0E4ABA006DCAC06F1FF7A289AA9713F5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_C558DAD0E81DD2982B7AA289AA985AB1" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:to="loc_us-gaap_VariableRateAxis_C558DAD0E81DD2982B7AA289AA985AB1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_3A1C791F54E2B8DABF46A289AA98F0D5_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_C558DAD0E81DD2982B7AA289AA985AB1" xlink:to="loc_us-gaap_VariableRateDomain_3A1C791F54E2B8DABF46A289AA98F0D5_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_3A1C791F54E2B8DABF46A289AA98F0D5" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_C558DAD0E81DD2982B7AA289AA985AB1" xlink:to="loc_us-gaap_VariableRateDomain_3A1C791F54E2B8DABF46A289AA98F0D5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrimeRateMember" xlink:label="loc_us-gaap_PrimeRateMember_C2316341EAFFE54F2230A289AA98FA16" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_3A1C791F54E2B8DABF46A289AA98F0D5" xlink:to="loc_us-gaap_PrimeRateMember_C2316341EAFFE54F2230A289AA98FA16" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_50E6A67B19BC336544F1A289AA98CEB1" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_258FAD727925224E89A5A289AA955DB4" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_50E6A67B19BC336544F1A289AA98CEB1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_50E6A67B19BC336544F1A289AA98CEB1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_50E6A67B19BC336544F1A289AA98CEB1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_4E4F1344936F6B23188EA289AA9956A4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_4E4F1344936F6B23188EA289AA9956A4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_3689585158DCC4AD17B6A289AA993547" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_3689585158DCC4AD17B6A289AA993547" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodThreeMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_5DCF1078FE92BF6BF416A289AA99C09C" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_55FB03DDEB806BE6033BA289AA989F31" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_5DCF1078FE92BF6BF416A289AA99C09C" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_LongTermDebtIssuable" xlink:label="loc_axnx_LongTermDebtIssuable_E071050355AF31717C1EA289AA99070E" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_LongTermDebtIssuable_E071050355AF31717C1EA289AA99070E" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_DebtInstrumentNumberofTranches" xlink:label="loc_axnx_DebtInstrumentNumberofTranches_9AA093CFD87848FAD3A6A289AA9A257C" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_DebtInstrumentNumberofTranches_9AA093CFD87848FAD3A6A289AA9A257C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_484BD281DDF19B360E73A289AA9A792E" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_484BD281DDF19B360E73A289AA9A792E" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_CollateralFeeContingencyMinimumGrossProceedsFromSaleOfEquitySecurities" xlink:label="loc_axnx_CollateralFeeContingencyMinimumGrossProceedsFromSaleOfEquitySecurities_5FAFA5C3B50186DA2DC5A289AA9A9A5A" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_CollateralFeeContingencyMinimumGrossProceedsFromSaleOfEquitySecurities_5FAFA5C3B50186DA2DC5A289AA9A9A5A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4E45C69024BA586D2324A289AA9ABAB9" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_4E45C69024BA586D2324A289AA9ABAB9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentCollateralFee" xlink:label="loc_us-gaap_DebtInstrumentCollateralFee_C60CFDC43C7D5F4229BCA289AA9A4DCC" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_us-gaap_DebtInstrumentCollateralFee_C60CFDC43C7D5F4229BCA289AA9A4DCC" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_CollateralFeeContingencyMinimumProceedsfromIPO" xlink:label="loc_axnx_CollateralFeeContingencyMinimumProceedsfromIPO_A436EBDC3A09331A293BA289AA9B4BAB" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_CollateralFeeContingencyMinimumProceedsfromIPO_A436EBDC3A09331A293BA289AA9B4BAB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFeeAmount" xlink:label="loc_us-gaap_DebtInstrumentFeeAmount_96E58DFB45FD9C2E0DC8A2EB1ED26CB7" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_us-gaap_DebtInstrumentFeeAmount_96E58DFB45FD9C2E0DC8A2EB1ED26CB7" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PrepaymentIncrementOfAmountsOutstanding" xlink:label="loc_axnx_PrepaymentIncrementOfAmountsOutstanding_3EB06B027654286C7849A289AA9BC462" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_PrepaymentIncrementOfAmountsOutstanding_3EB06B027654286C7849A289AA9BC462" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PeriodofPriorWrittenNoticebeforePrepaymentofAmountsOutstanding" xlink:label="loc_axnx_PeriodofPriorWrittenNoticebeforePrepaymentofAmountsOutstanding_94C827E063655EC5562DA289AAA01EC8" xlink:type="locator"/>
<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_PeriodofPriorWrittenNoticebeforePrepaymentofAmountsOutstanding_94C827E063655EC5562DA289AAA01EC8" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_PrepaymentofAmountsOutstandingFeePercentage" xlink:label="loc_axnx_PrepaymentofAmountsOutstandingFeePercentage_B5ED37A853563051AE64A289AAA02C47" xlink:type="locator"/>
<link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_PrepaymentofAmountsOutstandingFeePercentage_B5ED37A853563051AE64A289AAA02C47" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_LongTermDebtFinalPaymentFeeAsAPercentageOfOriginalPrincipalAmount" xlink:label="loc_axnx_LongTermDebtFinalPaymentFeeAsAPercentageOfOriginalPrincipalAmount_4E3FFE0D1D341095AE1DA289AAA00959" xlink:type="locator"/>
<link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_LongTermDebtFinalPaymentFeeAsAPercentageOfOriginalPrincipalAmount_4E3FFE0D1D341095AE1DA289AAA00959" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_VotingCapitalStockofForeignSubsidiariesExcludedfromFirstPriorityLienPercentage" xlink:label="loc_axnx_VotingCapitalStockofForeignSubsidiariesExcludedfromFirstPriorityLienPercentage_11FCEAA91ECD831051CEA289AAA08EC2" xlink:type="locator"/>
<link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4BD35FA8E46C0EA41E69A289AA998019" xlink:to="loc_axnx_VotingCapitalStockofForeignSubsidiariesExcludedfromFirstPriorityLienPercentage_11FCEAA91ECD831051CEA289AAA08EC2" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/LongTermDebtTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPolicies" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesFairValueHierarchyDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C93509CB6A205AFD16B96BBC3CFA3B50" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_045A32AFFBCE8EDBED1E6BBC3CEFCD36" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C93509CB6A205AFD16B96BBC3CFA3B50" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_045A32AFFBCE8EDBED1E6BBC3CEFCD36" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_A5C922134F3361E714DB6BBC3CF03A6B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_045A32AFFBCE8EDBED1E6BBC3CEFCD36" xlink:to="loc_us-gaap_FinancialInstrumentAxis_A5C922134F3361E714DB6BBC3CF03A6B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_A5C922134F3361E714DB6BBC3CF03A6B" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_A5C922134F3361E714DB6BBC3CF03A6B" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_512F339084D1166ABE2B6BBC3CF127EC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30" xlink:to="loc_us-gaap_CommercialPaperMember_512F339084D1166ABE2B6BBC3CF127EC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_E5B05C3F7E18EA10CA006BBC3CF85836" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_E5B05C3F7E18EA10CA006BBC3CF85836" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_EC5848DA5D3AD1FF79996BBC3CF8D78E" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6633BBD2A960C0F212516BBC3CF10D30" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_EC5848DA5D3AD1FF79996BBC3CF8D78E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0F132BF888850E90883C6BBC3CF8E54A" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_045A32AFFBCE8EDBED1E6BBC3CEFCD36" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0F132BF888850E90883C6BBC3CF8E54A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0F132BF888850E90883C6BBC3CF8E54A" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0F132BF888850E90883C6BBC3CF8E54A" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_49A0DD4E75975D71C98D6BBC3CFA0968" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_49A0DD4E75975D71C98D6BBC3CFA0968" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_38462FD28C90788F8BC76BBC3CFAB282" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_38462FD28C90788F8BC76BBC3CFAB282" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_839F65203C3475B546836BBC3CFAD58F" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6C50FA6EB7E48E3562236BBC3CF97FC9" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_839F65203C3475B546836BBC3CFAD58F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_CD45C167B9DC2C30F50B6BBC3CFBF9FC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C93509CB6A205AFD16B96BBC3CFA3B50" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_CD45C167B9DC2C30F50B6BBC3CFBF9FC" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="axnx-20191231.xsd#axnx_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:type="locator"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_86FE3389EBEB02FE7033A6D10C4D0F49" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:to="loc_us-gaap_AwardTypeAxis_86FE3389EBEB02FE7033A6D10C4D0F49" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_86FE3389EBEB02FE7033A6D10C4D0F49" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_86FE3389EBEB02FE7033A6D10C4D0F49" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember" xlink:label="loc_axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember_F3CEE10005F58CDC7A42A6D69AB7C0B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1" xlink:to="loc_axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember_F3CEE10005F58CDC7A42A6D69AB7C0B1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_8CC98054B33017B7852BA6D10C4DBFEE" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7B9DB9EE343131D48561A6D10C4DB3B1" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_8CC98054B33017B7852BA6D10C4DBFEE" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_AA6CF7D2AC70AC8EC7B5A6D10C4EC278" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_AA6CF7D2AC70AC8EC7B5A6D10C4EC278" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7398E374578AFE40BB38A6D10C4EC005_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_AA6CF7D2AC70AC8EC7B5A6D10C4EC278" xlink:to="loc_us-gaap_EquityComponentDomain_7398E374578AFE40BB38A6D10C4EC005_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7398E374578AFE40BB38A6D10C4EC005" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_AA6CF7D2AC70AC8EC7B5A6D10C4EC278" xlink:to="loc_us-gaap_EquityComponentDomain_7398E374578AFE40BB38A6D10C4EC005" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_8985A8BBCD0A64FBDCB8A6D10C4E567C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7398E374578AFE40BB38A6D10C4EC005" xlink:to="loc_us-gaap_CommonStockMember_8985A8BBCD0A64FBDCB8A6D10C4E567C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_49FB00FB4E27B97AB09BA6D10C4E22C2" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_49FB00FB4E27B97AB09BA6D10C4E22C2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_49FB00FB4E27B97AB09BA6D10C4E22C2" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_49FB00FB4E27B97AB09BA6D10C4E22C2" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IPOMember" xlink:label="loc_us-gaap_IPOMember_166133B7CF63DDE30888A6D10C4FD758" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59" xlink:to="loc_us-gaap_IPOMember_166133B7CF63DDE30888A6D10C4FD758" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OverAllotmentOptionMember" xlink:label="loc_us-gaap_OverAllotmentOptionMember_67910A575897DE8DAF21A6D10C4F0F33" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59" xlink:to="loc_us-gaap_OverAllotmentOptionMember_67910A575897DE8DAF21A6D10C4F0F33" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_FollowonOfferingMember" xlink:label="loc_axnx_FollowonOfferingMember_F2F6385ECC9FBC7FC796A6D10C4FD3F5" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_EB27CDD1123C0015B4DEA6D10C4F1A59" xlink:to="loc_axnx_FollowonOfferingMember_F2F6385ECC9FBC7FC796A6D10C4FD3F5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_9830F5338974F08F8D77A6D10C4FF450" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesTable_017AAF675D037DBCF7EFA6D10C4CC843" xlink:to="loc_srt_RangeAxis_9830F5338974F08F8D77A6D10C4FF450" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_9830F5338974F08F8D77A6D10C4FF450" xlink:to="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_9830F5338974F08F8D77A6D10C4FF450" xlink:to="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_B34DE4635A2C9460838BA6D10C50A4C1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11" xlink:to="loc_srt_MinimumMember_B34DE4635A2C9460838BA6D10C50A4C1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_6A7479C8703F36AF32B6A6D10C50EB98" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_AC3606D12110D7791DFCA6D10C506C11" xlink:to="loc_srt_MaximumMember_6A7479C8703F36AF32B6A6D10C50EB98" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDisclosuresAbstract" xlink:label="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_3958D06A2E9FD1A0E662A6D10C514A6D" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_3958D06A2E9FD1A0E662A6D10C514A6D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_9CC176F9FAB50D11D4F3A6D10C51BF40" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_9CC176F9FAB50D11D4F3A6D10C51BF40" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_0803FB4048F90D04A7C3A6D10C51C9ED" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_0803FB4048F90D04A7C3A6D10C51C9ED" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_D3E188A4D409024BF6CBA6D10C512BBB" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_D3E188A4D409024BF6CBA6D10C512BBB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_66ADFD9AB9AC0FDF85BCA6D10C5235F1" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDisclosuresAbstract_195068A3B689B25ACF27A6D10C50E825" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_66ADFD9AB9AC0FDF85BCA6D10C5235F1" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_BasisOfPresentationAndLiquidityAbstract" xlink:label="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_F90E5E77F79FEFBA514AA6D10C52FB2B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_F90E5E77F79FEFBA514AA6D10C52FB2B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1" xlink:label="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_03D9C99B1C25F670D1ADA6D10C52C543" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:to="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_03D9C99B1C25F670D1ADA6D10C52C543" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SaleofStockQualifiedIPOMinimumPricePerShare" xlink:label="loc_axnx_SaleofStockQualifiedIPOMinimumPricePerShare_408AE83940D2DFF17B10A6D10C52EE94" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:to="loc_axnx_SaleofStockQualifiedIPOMinimumPricePerShare_408AE83940D2DFF17B10A6D10C52EE94" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_B1639FC82C939DAC4AAEA6D10C534973" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_BasisOfPresentationAndLiquidityAbstract_5225C190001FD36549BAA6D10C522F4C" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_B1639FC82C939DAC4AAEA6D10C534973" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAbstract" xlink:label="loc_us-gaap_DebtSecuritiesAbstract_1D91DC5B39F6456F61BEA6D10C53DB86" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_DebtSecuritiesAbstract_1D91DC5B39F6456F61BEA6D10C53DB86" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesUnrealizedGainLoss" xlink:label="loc_us-gaap_DebtSecuritiesUnrealizedGainLoss_FE5F8E003D0A0481F842A6D10C530760" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesAbstract_1D91DC5B39F6456F61BEA6D10C53DB86" xlink:to="loc_us-gaap_DebtSecuritiesUnrealizedGainLoss_FE5F8E003D0A0481F842A6D10C530760" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_InventoryShelfLife" xlink:label="loc_axnx_InventoryShelfLife_5CA6CA45C57E63B2087BA6D10C536B5B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:to="loc_axnx_InventoryShelfLife_5CA6CA45C57E63B2087BA6D10C536B5B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_C3DFDBDF78152586D5E3A6D10C549F72" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_C3DFDBDF78152586D5E3A6D10C549F72" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_91EE14BA7C3B8829D364A6D10C544BD9" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_91EE14BA7C3B8829D364A6D10C544BD9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_EE66505DBFD5DF97621AA6D10C545F87" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_EE66505DBFD5DF97621AA6D10C545F87" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_us-gaap_InventoryValuationReserves_FC85EDA351B754B3D666A6D10C543348" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryNetAbstract_35EE440BA5B19FF9ED10A6D10C53BE0D" xlink:to="loc_us-gaap_InventoryValuationReserves_FC85EDA351B754B3D666A6D10C543348" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_422130170D0E46C766F5A6D10C545BC9" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAbstract_422130170D0E46C766F5A6D10C545BC9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_74CE4DBD337CCE96758EA6D10C54FE6F" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_422130170D0E46C766F5A6D10C545BC9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_74CE4DBD337CCE96758EA6D10C54FE6F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets_17F99156B4D9BB76088CA6D10C555E79" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets_17F99156B4D9BB76088CA6D10C555E79" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValuePurchaseOfAssets" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValuePurchaseOfAssets_847B1232A93DF874DAF9A6D10C559BB7" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValuePurchaseOfAssets_847B1232A93DF874DAF9A6D10C559BB7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinitelivedIntangibleAssetsAcquired1" xlink:label="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_235D6F0CC23F7DC8CD60A6D10C550985" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:to="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_235D6F0CC23F7DC8CD60A6D10C550985" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_6C0B4907BBCEB28B2D80A6D10C56C768" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_6C0B4907BBCEB28B2D80A6D10C56C768" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_0080235F5D515E428CC9A6D10C56E754" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_A18C4016873ED95B1AD6A6D10C558144" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_0080235F5D515E428CC9A6D10C56E754" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetImpairmentChargesAbstract" xlink:label="loc_us-gaap_AssetImpairmentChargesAbstract_6E8412FE8166F6E6BA75A6D10C56C6AD" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_AssetImpairmentChargesAbstract_6E8412FE8166F6E6BA75A6D10C56C6AD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsHeldForUse" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_443FA0948D1BE29DAED5A6D10C56A0DD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetImpairmentChargesAbstract_6E8412FE8166F6E6BA75A6D10C56C6AD" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_443FA0948D1BE29DAED5A6D10C56A0DD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseDescriptionAbstract" xlink:label="loc_us-gaap_LesseeOperatingLeaseDescriptionAbstract_5CA90C62BC5C6ED04871A6D10C5644EC" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_LesseeOperatingLeaseDescriptionAbstract_5CA90C62BC5C6ED04871A6D10C5644EC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_6CB0506121F28263EE3BA6D10C56D202" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeOperatingLeaseDescriptionAbstract_5CA90C62BC5C6ED04871A6D10C5644EC" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_6CB0506121F28263EE3BA6D10C56D202" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseDiscountRate" xlink:label="loc_us-gaap_LesseeOperatingLeaseDiscountRate_FCB7E9E38A1011682E16A6D10C57727F" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeOperatingLeaseDescriptionAbstract_5CA90C62BC5C6ED04871A6D10C5644EC" xlink:to="loc_us-gaap_LesseeOperatingLeaseDiscountRate_FCB7E9E38A1011682E16A6D10C57727F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract_FE75C67FB9E4BD58541EA6D10C572A3A" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_ShareBasedCompensationAbstract_FE75C67FB9E4BD58541EA6D10C572A3A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_7CDCA02433E78CF25C34A6D10C573061" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_FE75C67FB9E4BD58541EA6D10C572A3A" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_7CDCA02433E78CF25C34A6D10C573061" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_1CEB10C15581589EA36DA6D10C577225" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_FE75C67FB9E4BD58541EA6D10C572A3A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_1CEB10C15581589EA36DA6D10C577225" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_4BFBA206C20C33B42EBAA6D10C586058" xlink:type="locator"/>
<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_axnx_SummaryOfSignificantAccountingPoliciesLineItems_C96320138C748423F33DA6D10C506B47" xlink:to="loc_us-gaap_EarningsPerShareAbstract_4BFBA206C20C33B42EBAA6D10C586058" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_95E786F3D38D67CD017BA6D10C58ADF6" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_4BFBA206C20C33B42EBAA6D10C586058" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_95E786F3D38D67CD017BA6D10C58ADF6" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesRevenueByGeographicMarketDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_D3AF9CBF247EE46CF48F72B3C3EFB696" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_57776C07D5FC52AE66A672B3C3EE8FB4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_D3AF9CBF247EE46CF48F72B3C3EFB696" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_57776C07D5FC52AE66A672B3C3EE8FB4" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_A1512C0ECC1339696BC872B4B8531881" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_57776C07D5FC52AE66A672B3C3EE8FB4" xlink:to="loc_srt_StatementGeographicalAxis_A1512C0ECC1339696BC872B4B8531881" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_A1512C0ECC1339696BC872B4B8531881" xlink:to="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_A1512C0ECC1339696BC872B4B8531881" xlink:to="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9" xlink:type="arc"/>
<link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_6516ACC98D5EC50F5A7E72B4DDC61B2A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9" xlink:to="loc_country_US_6516ACC98D5EC50F5A7E72B4DDC61B2A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonUsMember" xlink:label="loc_us-gaap_NonUsMember_485A8A0BB2630652B22172B514BDAF51" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_AE007510545B0BE1E75072B584D5E1A9" xlink:to="loc_us-gaap_NonUsMember_485A8A0BB2630652B22172B514BDAF51" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_A504A48E5BED88FD22EB72B45C2AE99D" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_D3AF9CBF247EE46CF48F72B3C3EFB696" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_A504A48E5BED88FD22EB72B45C2AE99D" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NatureOfOperationsAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NoncontrollingInterest" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/NoncontrollingInterestNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestLineItems" xlink:label="loc_us-gaap_MinorityInterestLineItems_04829A1DC6F7E579BCE6676F9F802E67" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestTable" xlink:label="loc_us-gaap_MinorityInterestTable_58CDCBFB14611ABAE00D676F9F7EDDD2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MinorityInterestLineItems_04829A1DC6F7E579BCE6676F9F802E67" xlink:to="loc_us-gaap_MinorityInterestTable_58CDCBFB14611ABAE00D676F9F7EDDD2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_90F785151CC5D06409AD676F9F7E109F" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_58CDCBFB14611ABAE00D676F9F7EDDD2" xlink:to="loc_dei_LegalEntityAxis_90F785151CC5D06409AD676F9F7E109F" xlink:type="arc"/>
<link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_832F14692A09E42483CC676F9F7F012A_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_90F785151CC5D06409AD676F9F7E109F" xlink:to="loc_dei_EntityDomain_832F14692A09E42483CC676F9F7F012A_default" xlink:type="arc"/>
<link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_832F14692A09E42483CC676F9F7F012A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_90F785151CC5D06409AD676F9F7E109F" xlink:to="loc_dei_EntityDomain_832F14692A09E42483CC676F9F7F012A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_AxonicsEuropeS.A.S.Member" xlink:label="loc_axnx_AxonicsEuropeS.A.S.Member_EDC483F31D31281C74A2676F9F7FEA15" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_832F14692A09E42483CC676F9F7F012A" xlink:to="loc_axnx_AxonicsEuropeS.A.S.Member_EDC483F31D31281C74A2676F9F7FEA15" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2AAD9FC71D340A609D98676F9F7FC3EB" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_58CDCBFB14611ABAE00D676F9F7EDDD2" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2AAD9FC71D340A609D98676F9F7FC3EB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_C135F9A7E6D452489947676F9F7FEE6E_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2AAD9FC71D340A609D98676F9F7FC3EB" xlink:to="loc_us-gaap_EquityComponentDomain_C135F9A7E6D452489947676F9F7FEE6E_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_C135F9A7E6D452489947676F9F7FEE6E" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2AAD9FC71D340A609D98676F9F7FC3EB" xlink:to="loc_us-gaap_EquityComponentDomain_C135F9A7E6D452489947676F9F7FEE6E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_12C47DFFBFED6454456E676F9F80A287" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_C135F9A7E6D452489947676F9F7FEE6E" xlink:to="loc_us-gaap_CommonStockMember_12C47DFFBFED6454456E676F9F80A287" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_0FB86EE0888A7017EB6F676F9F81A045" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_04829A1DC6F7E579BCE6676F9F802E67" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_0FB86EE0888A7017EB6F676F9F81A045" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/PropertyAndEquipment" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/PropertyAndEquipmentNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_49E00B7B1C501EE0049F676F9F9170A1" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_26A22C67881E6FAD5CE5676F9F8F7354" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_49E00B7B1C501EE0049F676F9F9170A1" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_26A22C67881E6FAD5CE5676F9F8F7354" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_31F7C2FE3D2DE1D2CB57676F9F8F6C14" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_26A22C67881E6FAD5CE5676F9F8F7354" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_31F7C2FE3D2DE1D2CB57676F9F8F6C14" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0DDE145C2D538E10962A676F9F8F9FC4_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_31F7C2FE3D2DE1D2CB57676F9F8F6C14" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0DDE145C2D538E10962A676F9F8F9FC4_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0DDE145C2D538E10962A676F9F8F9FC4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_31F7C2FE3D2DE1D2CB57676F9F8F6C14" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0DDE145C2D538E10962A676F9F8F9FC4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentMember" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentMember_E7DF110781236E990890676F9F9092A6" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0DDE145C2D538E10962A676F9F8F9FC4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentMember_E7DF110781236E990890676F9F9092A6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_F99166503C4D68AA4303676F9F91A1C0" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_49E00B7B1C501EE0049F676F9F9170A1" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_F99166503C4D68AA4303676F9F91A1C0" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/PropertyAndEquipmentSummaryDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A0CA7900153199FF641672AAFD1F30EA" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_626ECAA3EF95A470F47372AAFD1D3889" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A0CA7900153199FF641672AAFD1F30EA" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_626ECAA3EF95A470F47372AAFD1D3889" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_B9071610D0417B5ABFD872AAFD1D4C70" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_626ECAA3EF95A470F47372AAFD1D3889" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_B9071610D0417B5ABFD872AAFD1D4C70" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_B9071610D0417B5ABFD872AAFD1D4C70" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_B9071610D0417B5ABFD872AAFD1D4C70" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ResearchandDevelopmentEquipmentMember" xlink:label="loc_axnx_ResearchandDevelopmentEquipmentMember_873C0E18F9A0499D9E07730A80BB28A7" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_axnx_ResearchandDevelopmentEquipmentMember_873C0E18F9A0499D9E07730A80BB28A7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComputerEquipmentMember" xlink:label="loc_us-gaap_ComputerEquipmentMember_73F8D765208755A2EA8272AAFD1ECB4D" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_us-gaap_ComputerEquipmentMember_73F8D765208755A2EA8272AAFD1ECB4D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ToolsDiesAndMoldsMember" xlink:label="loc_us-gaap_ToolsDiesAndMoldsMember_69A2BF004F0A1EAF541A72AAFD1F9CC0" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_us-gaap_ToolsDiesAndMoldsMember_69A2BF004F0A1EAF541A72AAFD1F9CC0" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_D8464ECDEB09149AB3C472AAFD1F3448" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_D8464ECDEB09149AB3C472AAFD1F3448" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_867E5F56AFD0FA71C8EE72AAFD1F7FA8" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_867E5F56AFD0FA71C8EE72AAFD1F7FA8" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_22DFE3921E47B8B42373730A2F4A5333" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_BDF402C623223E09930A72AAFD1E2242" xlink:to="loc_us-gaap_ConstructionInProgressMember_22DFE3921E47B8B42373730A2F4A5333" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_5EE5133ED02C33B894B672AAFD1F3ACC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A0CA7900153199FF641672AAFD1F30EA" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_5EE5133ED02C33B894B672AAFD1F3ACC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_C875E3B488077C59CBA672AAFD1FD926" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A0CA7900153199FF641672AAFD1F30EA" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_C875E3B488077C59CBA672AAFD1FD926" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_5AD33B66F691CBFAD3EB72AAFD20A4EB" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A0CA7900153199FF641672AAFD1F30EA" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_5AD33B66F691CBFAD3EB72AAFD20A4EB" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/PropertyAndEquipmentTables" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/RelatedPartyTransactions" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_978D16370CCB745341C39C117D2540AA" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_9B771CA36B704ABA95A19C117D22CB65" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_978D16370CCB745341C39C117D2540AA" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_9B771CA36B704ABA95A19C117D22CB65" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_A0059DEC8E661A151FD29C117D23574B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_9B771CA36B704ABA95A19C117D22CB65" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_A0059DEC8E661A151FD29C117D23574B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_A0059DEC8E661A151FD29C117D23574B" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_A0059DEC8E661A151FD29C117D23574B" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ScientificAdvisoryMember" xlink:label="loc_axnx_ScientificAdvisoryMember_1F432CF96FD0949F378A9C117D24E31B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476" xlink:to="loc_axnx_ScientificAdvisoryMember_1F432CF96FD0949F378A9C117D24E31B" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_EngineeringAndDesignServicesMember" xlink:label="loc_axnx_EngineeringAndDesignServicesMember_F305939758B0174B4F8A9C117D24BBB3" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_5EC37159F2801B0F67959C117D24C476" xlink:to="loc_axnx_EngineeringAndDesignServicesMember_F305939758B0174B4F8A9C117D24BBB3" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_3DB7C4B2A3024E8EB00D9C117D255BBA" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_978D16370CCB745341C39C117D2540AA" xlink:to="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_3DB7C4B2A3024E8EB00D9C117D255BBA" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent_2E4412772914DDFE9A649C117D256F3C" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_978D16370CCB745341C39C117D2540AA" xlink:to="loc_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent_2E4412772914DDFE9A649C117D256F3C" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_StockholdersEquityNoteSubscriptionsReceivableForgiven" xlink:label="loc_axnx_StockholdersEquityNoteSubscriptionsReceivableForgiven_1CC4104A42611B6C93E29C117D25D820" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_978D16370CCB745341C39C117D2540AA" xlink:to="loc_axnx_StockholdersEquityNoteSubscriptionsReceivableForgiven_1CC4104A42611B6C93E29C117D25D820" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquity" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityCommonStockReservedForFutureIssuanceDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3585581A804B9A77F046A289AA1D8492" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_626257E967CF1333AE1CA289AA160004" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3585581A804B9A77F046A289AA1D8492" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_626257E967CF1333AE1CA289AA160004" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_DC9C9909F35613E33C0CA289AA161641" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_626257E967CF1333AE1CA289AA160004" xlink:to="loc_us-gaap_AwardTypeAxis_DC9C9909F35613E33C0CA289AA161641" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_DC9C9909F35613E33C0CA289AA161641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_DC9C9909F35613E33C0CA289AA161641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_9D7EC23DA68F90E2B630A289AA1754FE" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068" xlink:to="loc_us-gaap_EmployeeStockOptionMember_9D7EC23DA68F90E2B630A289AA1754FE" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember" xlink:label="loc_axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember_87A0DDD4C50ED931DBD5A289AA17A62B" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E14882BF9CD076167595A289AA179068" xlink:to="loc_axnx_EmployeeStockOptionandRestrictedStockBasedAwardsMember_87A0DDD4C50ED931DBD5A289AA17A62B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_9EFEB6DB8701EB4446C8A289AA17E732" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_626257E967CF1333AE1CA289AA160004" xlink:to="loc_us-gaap_PlanNameAxis_9EFEB6DB8701EB4446C8A289AA17E732" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_9EFEB6DB8701EB4446C8A289AA17E732" xlink:to="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_9EFEB6DB8701EB4446C8A289AA17E732" xlink:to="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TwoThousandFourteenStockOptionPlanMember" xlink:label="loc_axnx_TwoThousandFourteenStockOptionPlanMember_AC8CFE10D6428F14217CA289AA1D0DE7" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3" xlink:to="loc_axnx_TwoThousandFourteenStockOptionPlanMember_AC8CFE10D6428F14217CA289AA1D0DE7" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TwoThousandEighteenStockOptionPlanMember" xlink:label="loc_axnx_TwoThousandEighteenStockOptionPlanMember_B8FD570B958C2DADD0CEA289AA1D7B3C" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_F665B76F1AE50F9587D8A289AA17C4A3" xlink:to="loc_axnx_TwoThousandEighteenStockOptionPlanMember_B8FD570B958C2DADD0CEA289AA1D7B3C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_5C877A85CE56BE471731A289AA1D49AC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3585581A804B9A77F046A289AA1D8492" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_5C877A85CE56BE471731A289AA1D49AC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_30D808380FA647EB8904A289AA1E2168" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3585581A804B9A77F046A289AA1D8492" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_30D808380FA647EB8904A289AA1E2168" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_08989C021932AFB6F159A289AA1EC474" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3585581A804B9A77F046A289AA1D8492" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_08989C021932AFB6F159A289AA1EC474" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityFairValueAssumptionsDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_58D665F231414240E843676FA0496877" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F745AB198B9B48591BF8676FA0474A3C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_58D665F231414240E843676FA0496877" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F745AB198B9B48591BF8676FA0474A3C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_BB1249795E85387D4067676FA048D8F4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F745AB198B9B48591BF8676FA0474A3C" xlink:to="loc_srt_RangeAxis_BB1249795E85387D4067676FA048D8F4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_BB1249795E85387D4067676FA048D8F4" xlink:to="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_BB1249795E85387D4067676FA048D8F4" xlink:to="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_26DF5F4D1BAB78DEF6B7676FA049156F" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10" xlink:to="loc_srt_MinimumMember_26DF5F4D1BAB78DEF6B7676FA049156F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_2E73AB2FD688EAD7D6B8676FA049D38E" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_98439EA6A07ACE33C84E676FA0481C10" xlink:to="loc_srt_MaximumMember_2E73AB2FD688EAD7D6B8676FA049D38E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_58D665F231414240E843676FA0496877" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_61DD7963B5506918E48F676FA04A6DEB" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_61DD7963B5506918E48F676FA04A6DEB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_170739E976F146FE73E2676FA04A4C12" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_170739E976F146FE73E2676FA04A4C12" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_631EF992E5F6EEB48811676FA04A5E14" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_631EF992E5F6EEB48811676FA04A5E14" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_595BEC2B586320391C1E676FA04B0325" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_595BEC2B586320391C1E676FA04B0325" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_CBA21AC9F198AAE17281676FA04B9F50" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_CBA21AC9F198AAE17281676FA04B9F50" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_10E1EA76948461D2542A676FA04BD627" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_5B069975FE4797B22F05676FA04A3E2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_10E1EA76948461D2542A676FA04BD627" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityPreferredStockNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConversionOfStockLineItems" xlink:label="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConversionOfStockTable" xlink:label="loc_us-gaap_ConversionOfStockTable_E8D853519D8FAB1DE113676FA03B7C1D" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:to="loc_us-gaap_ConversionOfStockTable_E8D853519D8FAB1DE113676FA03B7C1D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_DC14B884DC0C0C08D952676FA03B5ED4" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConversionOfStockTable_E8D853519D8FAB1DE113676FA03B7C1D" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_DC14B884DC0C0C08D952676FA03B5ED4" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_6ADAF1E3B2049A4A8913676FA03CE81B_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_DC14B884DC0C0C08D952676FA03B5ED4" xlink:to="loc_us-gaap_EquityComponentDomain_6ADAF1E3B2049A4A8913676FA03CE81B_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_6ADAF1E3B2049A4A8913676FA03CE81B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_DC14B884DC0C0C08D952676FA03B5ED4" xlink:to="loc_us-gaap_EquityComponentDomain_6ADAF1E3B2049A4A8913676FA03CE81B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_B00C7DCD2B01B6886A7B676FA03C0F19" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6ADAF1E3B2049A4A8913676FA03CE81B" xlink:to="loc_us-gaap_CommonStockMember_B00C7DCD2B01B6886A7B676FA03C0F19" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_AF6341A8C2A75B22107D676FA03D84AE" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_AF6341A8C2A75B22107D676FA03D84AE" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_476356E4987C310E666F676FA03D14B9" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_476356E4987C310E666F676FA03D14B9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_CE37E1A8286C721BADB1676FA03DA02D" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_CE37E1A8286C721BADB1676FA03DA02D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_29323A566B7E34E98942676FA03D1B4F" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockLineItems_171C4C503F4C49F48D4F676FA03C728C" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_29323A566B7E34E98942676FA03D1B4F" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityRestrictedSharesAwardNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B77A1E91AE81BF7EB03A73A8F9CC9682" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2504AB6B6B68F7C47C0C73A8F9CA04AE" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B77A1E91AE81BF7EB03A73A8F9CC9682" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2504AB6B6B68F7C47C0C73A8F9CA04AE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_A9EEBE7FA496C0B9304273A8FA07F0FB" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2504AB6B6B68F7C47C0C73A8F9CA04AE" xlink:to="loc_us-gaap_AwardTypeAxis_A9EEBE7FA496C0B9304273A8FA07F0FB" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7D748215263188AE3A6F73A8FA0A6BA6_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_A9EEBE7FA496C0B9304273A8FA07F0FB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7D748215263188AE3A6F73A8FA0A6BA6_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7D748215263188AE3A6F73A8FA0A6BA6" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_A9EEBE7FA496C0B9304273A8FA07F0FB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7D748215263188AE3A6F73A8FA0A6BA6" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_1EF31A1C7E38410382A173A945AB9D4D" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7D748215263188AE3A6F73A8FA0A6BA6" xlink:to="loc_us-gaap_RestrictedStockMember_1EF31A1C7E38410382A173A945AB9D4D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_46C26DFE3ABA991F141A73A8F9E2E092" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B77A1E91AE81BF7EB03A73A8F9CC9682" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_46C26DFE3ABA991F141A73A8F9E2E092" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_CBB7EE663326FEA7666E73A8F9F65F86" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B77A1E91AE81BF7EB03A73A8F9CC9682" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_CBB7EE663326FEA7666E73A8F9F65F86" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityRestrictedSharesAwardsActivityDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56DEBC1B6ED5C996684D7392CD13C3B7" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F870C62272DA8BDE6C1F7392CD1103D2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56DEBC1B6ED5C996684D7392CD13C3B7" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F870C62272DA8BDE6C1F7392CD1103D2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_0C965CBAF8F72F8E4E717392CD12EE42" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F870C62272DA8BDE6C1F7392CD1103D2" xlink:to="loc_us-gaap_AwardTypeAxis_0C965CBAF8F72F8E4E717392CD12EE42" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1EEADBE682978D6858A17392CD12A48B_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_0C965CBAF8F72F8E4E717392CD12EE42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1EEADBE682978D6858A17392CD12A48B_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1EEADBE682978D6858A17392CD12A48B" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_0C965CBAF8F72F8E4E717392CD12EE42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1EEADBE682978D6858A17392CD12A48B" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_6B4B61483B063CE6163A7392CD13621C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1EEADBE682978D6858A17392CD12A48B" xlink:to="loc_us-gaap_RestrictedStockMember_6B4B61483B063CE6163A7392CD13621C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56DEBC1B6ED5C996684D7392CD13C3B7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_0DF05507719F70D445367392CD1358C1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_0DF05507719F70D445367392CD1358C1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_55376DA61420964E76D57392CD141C02" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_55376DA61420964E76D57392CD141C02" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_90D5BC9556B3475AE6147392CD144B55" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_90D5BC9556B3475AE6147392CD144B55" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_B1505172FB3A885740167392CD14C866" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_EE5E8AB23334AA1CC8EF7392CD134980" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_B1505172FB3A885740167392CD14C866" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56DEBC1B6ED5C996684D7392CD13C3B7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_64030541EAFB3B0F37437392CD153886" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_64030541EAFB3B0F37437392CD153886" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_9FCAD4B6D5FAAD56CB517392CD155CFC" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_9FCAD4B6D5FAAD56CB517392CD155CFC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_2E89FABE61A9E84BAAC17392CD15F50F" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_2E89FABE61A9E84BAAC17392CD15F50F" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_6487E87FFB48CC8A2B817392CD15A5CE" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_C84DDC40D7C3FEA25BC77392CD15FCDF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_6487E87FFB48CC8A2B817392CD15A5CE" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityRestrictedStockUnitsActivityDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_892B4840B27654BF9DE97392CCEBF3F6" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E31DA19C33875317FAD7392CCEAACAC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_892B4840B27654BF9DE97392CCEBF3F6" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E31DA19C33875317FAD7392CCEAACAC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_2361DA18B3723FD40B007392CCEAFC42" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3E31DA19C33875317FAD7392CCEAACAC" xlink:to="loc_us-gaap_AwardTypeAxis_2361DA18B3723FD40B007392CCEAFC42" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_584F229EEB62896A84FC7392CCEB6A51_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_2361DA18B3723FD40B007392CCEAFC42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_584F229EEB62896A84FC7392CCEB6A51_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_584F229EEB62896A84FC7392CCEB6A51" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_2361DA18B3723FD40B007392CCEAFC42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_584F229EEB62896A84FC7392CCEB6A51" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_CB699B720A7E1FAF06437392CCEB33C3" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_584F229EEB62896A84FC7392CCEB6A51" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_CB699B720A7E1FAF06437392CCEB33C3" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_6E3C824027A934125EBD7392CCEBE84E" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_892B4840B27654BF9DE97392CCEBF3F6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_6E3C824027A934125EBD7392CCEBE84E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_671EC06A0374954385A27392CCEC9523" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_6E3C824027A934125EBD7392CCEBE84E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_671EC06A0374954385A27392CCEC9523" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_D8259892C9343B6F6F797392CCEC34E5" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_6E3C824027A934125EBD7392CCEBE84E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_D8259892C9343B6F6F797392CCEC34E5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_E097B275FB6FFAC9A0087392CCECF0A0" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_892B4840B27654BF9DE97392CCEBF3F6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_E097B275FB6FFAC9A0087392CCECF0A0" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_9E151CE53D388B8B00897392CCEDBE10" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_E097B275FB6FFAC9A0087392CCECF0A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_9E151CE53D388B8B00897392CCEDBE10" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8189938F87CA855CAA5C7392CCEDC2D8" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_E097B275FB6FFAC9A0087392CCECF0A0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8189938F87CA855CAA5C7392CCEDC2D8" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityRestrictedStockUnitsNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_439112A1FAED1BB67F3473A38DF9BEC5" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0E9CE6FDCFEF839CE1473A38DF8DF0C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_439112A1FAED1BB67F3473A38DF9BEC5" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0E9CE6FDCFEF839CE1473A38DF8DF0C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_BA8AC27948831D1F2E0973A4D11B56B7" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0E9CE6FDCFEF839CE1473A38DF8DF0C" xlink:to="loc_us-gaap_AwardTypeAxis_BA8AC27948831D1F2E0973A4D11B56B7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3D326BF1620BEC583EF573A4D33583CF_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_BA8AC27948831D1F2E0973A4D11B56B7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3D326BF1620BEC583EF573A4D33583CF_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3D326BF1620BEC583EF573A4D33583CF" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_BA8AC27948831D1F2E0973A4D11B56B7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3D326BF1620BEC583EF573A4D33583CF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_21D406B1A3ED325B0D1A73A4F592FFAD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3D326BF1620BEC583EF573A4D33583CF" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_21D406B1A3ED325B0D1A73A4F592FFAD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_97959C9B4B81655895A073A70323B81C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_439112A1FAED1BB67F3473A38DF9BEC5" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_97959C9B4B81655895A073A70323B81C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_E85134F6E87AB4BE487773A77DFC4A1B" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_439112A1FAED1BB67F3473A38DF9BEC5" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_E85134F6E87AB4BE487773A77DFC4A1B" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityStockBasedCompensationExpenseDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6934C66C29117F31EF6272AAFCAEF921" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0F2BF043373D7563C4FF72AAFCAC4B38" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6934C66C29117F31EF6272AAFCAEF921" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0F2BF043373D7563C4FF72AAFCAC4B38" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_C9038B936D0E8AECC6A372AAFCAC7ACC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0F2BF043373D7563C4FF72AAFCAC4B38" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_C9038B936D0E8AECC6A372AAFCAC7ACC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_C9038B936D0E8AECC6A372AAFCAC7ACC" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_C9038B936D0E8AECC6A372AAFCAC7ACC" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_4E5632E731E91ED6A6AE72AAFCAD8C93" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_4E5632E731E91ED6A6AE72AAFCAD8C93" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_A4538AE8C7D382E0458372AAFCADD4ED" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_A4538AE8C7D382E0458372AAFCADD4ED" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SellingAndMarketingExpenseMember" xlink:label="loc_us-gaap_SellingAndMarketingExpenseMember_1DC868EEE959160BE2FD72AAFCAD7386" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_2C62F6131D916587B00E72AAFCAD822D" xlink:to="loc_us-gaap_SellingAndMarketingExpenseMember_1DC868EEE959160BE2FD72AAFCAD7386" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_8A395FE2E15ADDCB8C3772AAFCAE31E6" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6934C66C29117F31EF6272AAFCAEF921" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_8A395FE2E15ADDCB8C3772AAFCAE31E6" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityStockOptionActivityDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityStockOptionNarrativeDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2397E73F005B991515C9A289AA2DECAA" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2397E73F005B991515C9A289AA2DECAA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_D0263A6BC2E6981C0E6BA289AA2D57B0" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2397E73F005B991515C9A289AA2DECAA" xlink:to="loc_us-gaap_PlanNameAxis_D0263A6BC2E6981C0E6BA289AA2D57B0" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_D0263A6BC2E6981C0E6BA289AA2D57B0" xlink:to="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_D0263A6BC2E6981C0E6BA289AA2D57B0" xlink:to="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TwoThousandFourteenStockOptionPlanMember" xlink:label="loc_axnx_TwoThousandFourteenStockOptionPlanMember_9B32E06026BA5ED8E202A289AA2DF4AB" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2" xlink:to="loc_axnx_TwoThousandFourteenStockOptionPlanMember_9B32E06026BA5ED8E202A289AA2DF4AB" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TwoThousandEighteenStockOptionPlanMember" xlink:label="loc_axnx_TwoThousandEighteenStockOptionPlanMember_AAB57D6D7F25D7723ADDA289AA2E2D65" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_2EAA4767DF23D70753B6A289AA2DC7C2" xlink:to="loc_axnx_TwoThousandEighteenStockOptionPlanMember_AAB57D6D7F25D7723ADDA289AA2E2D65" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_4E074599EF11064C185BA289AA2E9C6A" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2397E73F005B991515C9A289AA2DECAA" xlink:to="loc_us-gaap_AwardTypeAxis_4E074599EF11064C185BA289AA2E9C6A" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D29DAAACFC80DB4E7F3FA289AA2E45AC_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_4E074599EF11064C185BA289AA2E9C6A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D29DAAACFC80DB4E7F3FA289AA2E45AC_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D29DAAACFC80DB4E7F3FA289AA2E45AC" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_4E074599EF11064C185BA289AA2E9C6A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D29DAAACFC80DB4E7F3FA289AA2E45AC" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_828CCA803D929899FB25A289AA2E8C88" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D29DAAACFC80DB4E7F3FA289AA2E45AC" xlink:to="loc_us-gaap_EmployeeStockOptionMember_828CCA803D929899FB25A289AA2E8C88" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_61BADC9EF3224A385945A289AA2FA6B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_61BADC9EF3224A385945A289AA2FA6B1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_E2D75898F04E93BBC4AEA289AA2FD390" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_E2D75898F04E93BBC4AEA289AA2FD390" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_37244AA85FFC7F5652ABA289AA2F9469" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_37244AA85FFC7F5652ABA289AA2F9469" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_BB780AB7F0D609ACB593A289AA2F4DAE" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_BB780AB7F0D609ACB593A289AA2F4DAE" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_3449101C5A649A0AF528A289AA30BB24" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_3449101C5A649A0AF528A289AA30BB24" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_AE3A29A6B26F1CC880DBA289AA304DE8" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1905BDB5E109D37DA70CA289AA2EDB1A" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_AE3A29A6B26F1CC880DBA289AA304DE8" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityStockSubscriptionsReceivableDetails" xlink:type="extended"/>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityStockWarrantsDetails" xlink:type="extended">
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:type="locator"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_8ADFD1F1635798F24D39A6D10AA52277" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_8ADFD1F1635798F24D39A6D10AA52277" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_8ADFD1F1635798F24D39A6D10AA52277" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_8ADFD1F1635798F24D39A6D10AA52277" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SiliconValleyBankPreferredStockWarrantsMember" xlink:label="loc_axnx_SiliconValleyBankPreferredStockWarrantsMember_EE72FF5FB5270D2E8BC8A6D10AA67422" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF" xlink:to="loc_axnx_SiliconValleyBankPreferredStockWarrantsMember_EE72FF5FB5270D2E8BC8A6D10AA67422" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_LifeScienceLoansIILLCPreferredStockWarrantsMember" xlink:label="loc_axnx_LifeScienceLoansIILLCPreferredStockWarrantsMember_CE11201F79FA2AF9173AA6D10AA6032C" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_46B1C228580755F48F5EA6D10AA644FF" xlink:to="loc_axnx_LifeScienceLoansIILLCPreferredStockWarrantsMember_CE11201F79FA2AF9173AA6D10AA6032C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_1489221417E0DD18FC8CA6D10AA634B5" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_1489221417E0DD18FC8CA6D10AA634B5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_1489221417E0DD18FC8CA6D10AA634B5" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_1489221417E0DD18FC8CA6D10AA634B5" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_D0FDBC1D91E4EA7D32D8A6D10AA70F81" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_D0FDBC1D91E4EA7D32D8A6D10AA70F81" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_64E5FAB43518DD8D6BD4A6D10AA7217D" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_20F352211E46D9C67A88A6D10AA6E21C" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_64E5FAB43518DD8D6BD4A6D10AA7217D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_8C7E628BD63E0764C934A6D10AA7A009" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_StatementClassOfStockAxis_8C7E628BD63E0764C934A6D10AA7A009" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_787FFEAFBF80967090DEA6D10AA711B1_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8C7E628BD63E0764C934A6D10AA7A009" xlink:to="loc_us-gaap_ClassOfStockDomain_787FFEAFBF80967090DEA6D10AA711B1_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_787FFEAFBF80967090DEA6D10AA711B1" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8C7E628BD63E0764C934A6D10AA7A009" xlink:to="loc_us-gaap_ClassOfStockDomain_787FFEAFBF80967090DEA6D10AA711B1" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_524F887A1B2616BC17ACA6D10AA805CF" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_787FFEAFBF80967090DEA6D10AA711B1" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_524F887A1B2616BC17ACA6D10AA805CF" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_251DB91FF12A426F6EFCA6D10AA8DEA2" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_DebtInstrumentAxis_251DB91FF12A426F6EFCA6D10AA8DEA2" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_82C82986066334811965A6D10AA8EB4A_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_251DB91FF12A426F6EFCA6D10AA8DEA2" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_82C82986066334811965A6D10AA8EB4A_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_82C82986066334811965A6D10AA8EB4A" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_251DB91FF12A426F6EFCA6D10AA8DEA2" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_82C82986066334811965A6D10AA8EB4A" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_TermLoanTrancheBCMember" xlink:label="loc_axnx_TermLoanTrancheBCMember_FA40330B6EE29D342665A6D10AA9C7BD" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_82C82986066334811965A6D10AA8EB4A" xlink:to="loc_axnx_TermLoanTrancheBCMember_FA40330B6EE29D342665A6D10AA9C7BD" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2734F412F7562D5DF0DFA6D10AA96BD5" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2734F412F7562D5DF0DFA6D10AA96BD5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_73798419C7E71CB7AB11A6D10AA90823_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2734F412F7562D5DF0DFA6D10AA96BD5" xlink:to="loc_us-gaap_EquityComponentDomain_73798419C7E71CB7AB11A6D10AA90823_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_73798419C7E71CB7AB11A6D10AA90823" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2734F412F7562D5DF0DFA6D10AA96BD5" xlink:to="loc_us-gaap_EquityComponentDomain_73798419C7E71CB7AB11A6D10AA90823" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_CB472D5311628168B5E2A6D10AA91E80" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73798419C7E71CB7AB11A6D10AA90823" xlink:to="loc_us-gaap_CommonStockMember_CB472D5311628168B5E2A6D10AA91E80" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_8966DC65D1794354E30CA6D10AA99BA8" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_8966DC65D1794354E30CA6D10AA99BA8" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_2E313B5630F103FE9301A6D10AAAF4F5_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8966DC65D1794354E30CA6D10AA99BA8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_2E313B5630F103FE9301A6D10AAAF4F5_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_2E313B5630F103FE9301A6D10AAAF4F5" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8966DC65D1794354E30CA6D10AA99BA8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_2E313B5630F103FE9301A6D10AAAF4F5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilityMember" xlink:label="loc_us-gaap_LiabilityMember_DDB291A9C37FE6EF4483A6D10AAAAD72" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_2E313B5630F103FE9301A6D10AAAF4F5" xlink:to="loc_us-gaap_LiabilityMember_DDB291A9C37FE6EF4483A6D10AAAAD72" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_16D3F7F3DB44454E1A87A6D10AAA9568" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_2AB66460F42B78CB1C2DA6D10AA5CD9A" xlink:to="loc_us-gaap_AwardTypeAxis_16D3F7F3DB44454E1A87A6D10AAA9568" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C776678124E8DFF58C26A6D10AAB0747_default" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_16D3F7F3DB44454E1A87A6D10AAA9568" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C776678124E8DFF58C26A6D10AAB0747_default" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C776678124E8DFF58C26A6D10AAB0747" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_16D3F7F3DB44454E1A87A6D10AAA9568" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C776678124E8DFF58C26A6D10AAB0747" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_87957AED5E67E57A0B30A6D10AAB8B53" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C776678124E8DFF58C26A6D10AAB0747" xlink:to="loc_us-gaap_WarrantMember_87957AED5E67E57A0B30A6D10AAB8B53" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantOrRightIssuedAndIssuable" xlink:label="loc_axnx_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantOrRightIssuedAndIssuable_679E575A2CF863227650A6D10AB03694" xlink:type="locator"/>
<link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_axnx_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantOrRightIssuedAndIssuable_679E575A2CF863227650A6D10AB03694" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_FA91475E34447B11C3E3A6D10AB1FF9D" xlink:type="locator"/>
<link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_FA91475E34447B11C3E3A6D10AB1FF9D" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9212F68E41741F5ED2DEA6D10AB193F9" xlink:type="locator"/>
<link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_9212F68E41741F5ED2DEA6D10AB193F9" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_F36C30816E1979257697A6D10AB17191" xlink:type="locator"/>
<link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_F36C30816E1979257697A6D10AB17191" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingTerm" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_90C97C755C42F204AE09A6D10AB1866E" xlink:type="locator"/>
<link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_90C97C755C42F204AE09A6D10AB1866E" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_4163E49BB17D03A39620A6D10AB1B3B7" xlink:type="locator"/>
<link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_4163E49BB17D03A39620A6D10AB1B3B7" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_13B3219C80786CE45C5DA6D10AB2FCA5" xlink:type="locator"/>
<link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_13B3219C80786CE45C5DA6D10AB2FCA5" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_EC819DCD9EE7CAC3EFBCA6D10AB2257C" xlink:type="locator"/>
<link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_EC819DCD9EE7CAC3EFBCA6D10AB2257C" xlink:type="arc"/>
<link:loc xlink:href="axnx-20191231.xsd#axnx_SharebasedCompensationArrangementbySharebasedPaymentAwardWarrantsExercisedinPeriod" xlink:label="loc_axnx_SharebasedCompensationArrangementbySharebasedPaymentAwardWarrantsExercisedinPeriod_64D5BD9D6D55577E97BFA6D10AB27404" xlink:type="locator"/>
<link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_axnx_SharebasedCompensationArrangementbySharebasedPaymentAwardWarrantsExercisedinPeriod_64D5BD9D6D55577E97BFA6D10AB27404" xlink:type="arc"/>
<link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_222C328385F2C39AE8BBA6DA5B19EA09" xlink:type="locator"/>
<link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_E9B0F018655BCC65EAC9A6D10AB0426A" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_222C328385F2C39AE8BBA6DA5B19EA09" xlink:type="arc"/>
</link:definitionLink>
<link:definitionLink xlink:role="http://axonicsmodulation.com/role/StockholdersEquityTables" xlink:type="extended"/>
</link:linkbase>

6 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/04/22  Axonics, Inc.                     424B5                  2:533K
 8/02/22  Axonics, Inc.                     424B5                  1:507K
 5/13/21  Axonics, Inc.                     424B5                  1:530K
 5/11/21  Axonics, Inc.                     424B5                  1:522K
 4/30/21  Axonics, Inc.                     424B5                  1:419K
 3/03/21  Axonics, Inc.                     424B5       3/02/21    1:310K
↑Top
Filing Submission 0001603756-20-000013   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Tue., Apr. 30, 1:28:11.2am ET