SEC Info - Evolutionary Genomics, Inc. - ‘10-K’ for 12/31/20

SEC Info℠

Home

My Interests

Help

Please Sign In

Evolutionary Genomics, Inc. – ‘10-K’ for 12/31/20 – ‘EX-101.DEF’

On: Wednesday, 3/31/21, at 11:31am ET · For: 12/31/20 · Accession #: 1553350-21-252 · File #: 0-54129

Previous ‘10-K’: ‘10-K/A’ on 4/24/20 for 12/31/19 · Next: ‘10-K’ on 3/22/22 for 12/31/21 · Latest: ‘10-K’ on 3/9/23 for 12/31/22 · 12 References:

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/31/21  Evolutionary Genomics, Inc.       10-K       12/31/20   61:3.3M                                   Edgar Filing LLC/FA

Annual Report — Form 10-K
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML    510K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     20K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     20K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     17K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     17K 
12: R1          Document and Entity Information                     HTML     56K 
13: R2          Consolidated Balance Sheets                         HTML     98K 
14: R3          Consolidated Balance Sheets (Parenthetical)         HTML     40K 
15: R4          Consolidated Statements of Operations               HTML     76K 
16: R5          Consolidated Statement of Stockholders' Equity      HTML     59K 
17: R6          Consolidated Statements of Cash Flows               HTML     75K 
18: R7          Business Activity                                   HTML     22K 
19: R8          Summary of Significant Accounting Policies          HTML     29K 
20: R9          New Accounting Standards                            HTML     27K 
21: R10         Fair Value Measurements                             HTML     33K 
22: R11         Property and Equipment                              HTML     28K 
23: R12         Intangible Assets                                   HTML     33K 
24: R13         Income Taxes                                        HTML     67K 
25: R14         Notes Payable                                       HTML     23K 
26: R15         Stockholders' Equity and Warrants                   HTML     41K 
27: R16         Stock-Based Compensation                            HTML     56K 
28: R17         Commitments and Contingencies                       HTML     22K 
29: R18         Related Parties and Transactions                    HTML     20K 
30: R19         Concentrations                                      HTML     19K 
31: R20         Liquidity and Going Concern                         HTML     20K 
32: R21         Summary of Significant Accounting Policies          HTML     60K 
                (Policies)                                                       
33: R22         Fair Value Measurements (Tables)                    HTML     28K 
34: R23         Property and Equipment (Tables)                     HTML     27K 
35: R24         Intangible Assets (Tables)                          HTML     34K 
36: R25         Income Taxes (Tables)                               HTML     67K 
37: R26         Stockholders' Equity and Warrants (Tables)          HTML     37K 
38: R27         Stock-Based Compensation (Tables)                   HTML     55K 
39: R28         Business Activity (Details)                         HTML     18K 
40: R29         Summary of Significant Accounting Policies (Other)  HTML     19K 
                (Details)                                                        
41: R30         Summary of Significant Accounting Policies          HTML     22K 
                (Property and Equipment) (Details)                               
42: R31         Summary of Significant Accounting Policies          HTML     24K 
                (Intangilbe Assets) (Details)                                    
43: R32         Summary of Significant Accounting Policies (Net     HTML     32K 
                Loss Per Common Share) (Details)                                 
44: R33         Fair Value Measurements (Details)                   HTML     31K 
45: R34         Property and Equipment (Details)                    HTML     34K 
46: R35         Intangible Assets (Details)                         HTML     46K 
47: R36         Income Taxes (Narrative) (Details)                  HTML     29K 
48: R37         Income Taxes (Schedule of Income Tax Expense)       HTML     40K 
                (Details)                                                        
49: R38         Income Taxes (Income Tax Reconciliation) (Details)  HTML     46K 
50: R39         Income Taxes (Schedule of Deferred Tax Assets and   HTML     42K 
                Liabilities) (Details)                                           
51: R40         Notes Payable (Details)                             HTML     49K 
52: R41         Stockholders' Equity and Warrants (Narrative)       HTML     45K 
                (Details)                                                        
53: R42         Stockholders' Equity and Warrants (Summary of       HTML     40K 
                Warrants Activity) (Details)                                     
54: R43         Stock-Based Compensation (Narrative) (Details)      HTML     32K 
55: R44         Stock-Based Compensation (Summary of Stock Options  HTML     58K 
                Activity) (Details)                                              
56: R45         Commitments and Contingencies (Details)             HTML     26K 
57: R46         Related Parties and Transactions (Details)          HTML     21K 
58: R47         Liquidity and Going Concern (Details)               HTML     24K 
60: XML         IDEA XML File -- Filing Summary                      XML    106K 
59: EXCEL       IDEA Workbook of Financial Reports                  XLSX     57K 
 6: EX-101.INS  XBRL Instance -- fnam-20201231                       XML    841K 
 8: EX-101.CAL  XBRL Calculations -- fnam-20201231_cal               XML    161K 
 9: EX-101.DEF  XBRL Definitions -- fnam-20201231_def                XML    270K 
10: EX-101.LAB  XBRL Labels -- fnam-20201231_lab                     XML    703K 
11: EX-101.PRE  XBRL Presentations -- fnam-20201231_pre              XML    503K 
 7: EX-101.SCH  XBRL Schema -- fnam-20201231                         XSD    105K 
61: ZIP         XBRL Zipped Folder -- 0001553350-21-000252-xbrl      Zip     83K

‘EX-101.DEF’ — XBRL Definitions — fnam-20201231_def

This Exhibit is an XBRL XML File.

<?xml version="1.0" standalone="no" encoding="windows-1252"?>

<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-daei" xlink:href="fnam-20201231.xsd#fnam-daei" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/BalanceSheets" xlink:href="fnam-20201231.xsd#BalanceSheets" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/BalanceSheetsParenthetical" xlink:href="fnam-20201231.xsd#BalanceSheetsParenthetical" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StatementsOfOperations" xlink:href="fnam-20201231.xsd#StatementsOfOperations" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StatementOfStockholdersEquity" xlink:href="fnam-20201231.xsd#StatementOfStockholdersEquity" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StatementsOfCashFlows" xlink:href="fnam-20201231.xsd#StatementsOfCashFlows" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/NatureOfBusiness" xlink:href="fnam-20201231.xsd#NatureOfBusiness" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="fnam-20201231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/NewAccountingStandards" xlink:href="fnam-20201231.xsd#NewAccountingStandards" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/FairValueMeasurements" xlink:href="fnam-20201231.xsd#FairValueMeasurements" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/PropertyAndEquipment" xlink:href="fnam-20201231.xsd#PropertyAndEquipment" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IntangibleAssets" xlink:href="fnam-20201231.xsd#IntangibleAssets" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-it" xlink:href="fnam-20201231.xsd#fnam-it" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/NotesPayable" xlink:href="fnam-20201231.xsd#NotesPayable" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Disclosure-CommonStock" xlink:href="fnam-20201231.xsd#Disclosure-CommonStock" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Stock-basedCompensation" xlink:href="fnam-20201231.xsd#Stock-basedCompensation" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/CommitmentsAndContingencies" xlink:href="fnam-20201231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/RelatedPartiesAndTransactions" xlink:href="fnam-20201231.xsd#RelatedPartiesAndTransactions" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Concentrations" xlink:href="fnam-20201231.xsd#Concentrations" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/LiquidityAndGoingConcern" xlink:href="fnam-20201231.xsd#LiquidityAndGoingConcern" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-se" xlink:href="fnam-20201231.xsd#fnam-se" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-soapadobp" xlink:href="fnam-20201231.xsd#fnam-soapadobp" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/FairValueMeasurementsTables" xlink:href="fnam-20201231.xsd#FairValueMeasurementsTables" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/PropertyAndEquipmentTables" xlink:href="fnam-20201231.xsd#PropertyAndEquipmentTables" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IntangibleAssetsTables" xlink:href="fnam-20201231.xsd#IntangibleAssetsTables" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-itt" xlink:href="fnam-20201231.xsd#fnam-itt" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsTables" xlink:href="fnam-20201231.xsd#StockholdersEquityAndWarrantsTables" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationTables" xlink:href="fnam-20201231.xsd#Stock-basedCompensationTables" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/BusinessActivityDetails" xlink:href="fnam-20201231.xsd#BusinessActivityDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesOtherDetails" xlink:href="fnam-20201231.xsd#SummaryOfSignificantAccountingPoliciesOtherDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesPropertyAndEquipmentDetails" xlink:href="fnam-20201231.xsd#SummaryOfSignificantAccountingPoliciesPropertyAndEquipmentDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesIntangilbeAssetsDetails" xlink:href="fnam-20201231.xsd#SummaryOfSignificantAccountingPoliciesIntangilbeAssetsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesNetLossPerCommonShareDetails" xlink:href="fnam-20201231.xsd#SummaryOfSignificantAccountingPoliciesNetLossPerCommonShareDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/FairValueMeasurementsDetails" xlink:href="fnam-20201231.xsd#FairValueMeasurementsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/PropertyAndEquipmentDetails" xlink:href="fnam-20201231.xsd#PropertyAndEquipmentDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IntangibleAssetsDetails" xlink:href="fnam-20201231.xsd#IntangibleAssetsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IncomeTaxesNarrativeDetails" xlink:href="fnam-20201231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IncomeTaxesScheduleOfIncomeTaxExpenseDetails" xlink:href="fnam-20201231.xsd#IncomeTaxesScheduleOfIncomeTaxExpenseDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/fnam-ititrd" xlink:href="fnam-20201231.xsd#fnam-ititrd" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:href="fnam-20201231.xsd#IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/NotesPayableDetails" xlink:href="fnam-20201231.xsd#NotesPayableDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsNarrativeDetails" xlink:href="fnam-20201231.xsd#StockholdersEquityAndWarrantsNarrativeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsSummaryOfWarrantsActivityDetails" xlink:href="fnam-20201231.xsd#StockholdersEquityAndWarrantsSummaryOfWarrantsActivityDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationNarrativeDetails" xlink:href="fnam-20201231.xsd#Stock-basedCompensationNarrativeDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationSummaryOfStockOptionsActivityDetails" xlink:href="fnam-20201231.xsd#Stock-basedCompensationSummaryOfStockOptionsActivityDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/CommitmentsAndContingenciesDetails" xlink:href="fnam-20201231.xsd#CommitmentsAndContingenciesDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/RelatedPartiesAndTransactionsDetails" xlink:href="fnam-20201231.xsd#RelatedPartiesAndTransactionsDetails" xlink:type="simple"/>

<link:roleRef roleURI="http://evolutionarygenomicsinc.com/role/LiquidityAndGoingConcernDetails" xlink:href="fnam-20201231.xsd#LiquidityAndGoingConcernDetails" xlink:type="simple"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#notAll" arcroleURI="http://xbrl.org/int/dim/arcrole/notAll"/>

<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-daei" xlink:title="00000001 - Document - Document and Entity Information"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/BalanceSheets" xlink:title="00000002 - Statement - Consolidated Balance Sheets">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapStatementTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaapStatementClassOfStockAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapStatementTable" xlink:to="loc_us-gaapStatementClassOfStockAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapStatementClassOfStockAxis" xlink:to="loc_us-gaapClassOfStockDomain" xlink:type="arc" order="20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapStatementClassOfStockAxis" xlink:to="loc_us-gaapClassOfStockDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="loc_us-gaapSeriesAPreferredStockMember_20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockDomain" xlink:to="loc_us-gaapSeriesAPreferredStockMember_20" xlink:type="arc" order="21"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_SeriesA2PreferredStockMember" xlink:label="loc_fnamSeriesA2PreferredStockMember_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockDomain" xlink:to="loc_fnamSeriesA2PreferredStockMember_40" xlink:type="arc" order="41"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaapAssetsAbstract_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapAssetsAbstract_70" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaapAssetsCurrentAbstract_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsAbstract_70" xlink:to="loc_us-gaapAssetsCurrentAbstract_70" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsCurrentAbstract_70" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue_70" xlink:type="arc" order="2"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaapAccountsReceivableNetCurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsCurrentAbstract_70" xlink:to="loc_us-gaapAccountsReceivableNetCurrent_70" xlink:type="arc" order="3"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaapShortTermInvestments_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsCurrentAbstract_70" xlink:to="loc_us-gaapShortTermInvestments_70" xlink:type="arc" order="4"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaapPrepaidExpenseCurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsCurrentAbstract_70" xlink:to="loc_us-gaapPrepaidExpenseCurrent_70" xlink:type="arc" order="5"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="loc_us-gaapAssetsNoncurrentAbstract_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsNoncurrentAbstract_70" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet_70" xlink:type="arc" order="8"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsNet_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsNoncurrentAbstract_70" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsNet_70" xlink:type="arc" order="9"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsNoncurrent" xlink:label="loc_us-gaapAssetsNoncurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsNoncurrentAbstract_70" xlink:to="loc_us-gaapAssetsNoncurrent_70" xlink:type="arc" order="10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAssetsAbstract_70" xlink:to="loc_us-gaapAssets_70" xlink:type="arc" order="11"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaapLiabilitiesCurrentAbstract_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapLiabilitiesCurrentAbstract_70" xlink:type="arc" order="13"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesCurrentAbstract_70" xlink:to="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent_70" xlink:type="arc" order="14"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableCurrent" xlink:label="loc_us-gaapNotesPayableCurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesCurrentAbstract_70" xlink:to="loc_us-gaapNotesPayableCurrent_70" xlink:type="arc" order="15"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesCurrentAbstract_70" xlink:to="loc_us-gaapLiabilitiesCurrent_70" xlink:type="arc" order="16"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaapLiabilitiesNoncurrentAbstract_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapLiabilitiesNoncurrentAbstract_70" xlink:type="arc" order="17"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermNotesPayable" xlink:label="loc_us-gaapLongTermNotesPayable_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesNoncurrentAbstract_70" xlink:to="loc_us-gaapLongTermNotesPayable_70" xlink:type="arc" order="18"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaapDeferredIncomeTaxLiabilitiesNet_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesNoncurrentAbstract_70" xlink:to="loc_us-gaapDeferredIncomeTaxLiabilitiesNet_70" xlink:type="arc" order="19"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaapCommitmentsAndContingencies_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapCommitmentsAndContingencies_70" xlink:type="arc" order="21"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent" xlink:label="loc_us-gaapTemporaryEquityCarryingAmountAttributableToParent_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapTemporaryEquityCarryingAmountAttributableToParent_70" xlink:type="arc" order="22"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaapStockholdersEquityAbstract_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapStockholdersEquityAbstract_70" xlink:type="arc" order="23"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStockholdersEquityAbstract_70" xlink:to="loc_us-gaapPreferredStockValue_70" xlink:type="arc" order="24"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStockholdersEquityAbstract_70" xlink:to="loc_us-gaapCommonStockValue_70" xlink:type="arc" order="25"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaapAdditionalPaidInCapitalCommonStock_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStockholdersEquityAbstract_70" xlink:to="loc_us-gaapAdditionalPaidInCapitalCommonStock_70" xlink:type="arc" order="26"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStockholdersEquityAbstract_70" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit_70" xlink:type="arc" order="27"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStockholdersEquityAbstract_70" xlink:to="loc_us-gaapStockholdersEquity_70" xlink:type="arc" order="28"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity_70"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquityAbstract_70" xlink:to="loc_us-gaapLiabilitiesAndStockholdersEquity_70" xlink:type="arc" order="29"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/BalanceSheetsParenthetical" xlink:title="00000003 - Statement - Consolidated Balance Sheets (Parenthetical)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain_10"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_SeriesA2PreferredStockMember" xlink:label="loc_fnamSeriesA2PreferredStockMember_40"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaapPreferredStockParOrStatedValuePerShare_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaapPreferredStockSharesAuthorized_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaapPreferredStockSharesIssued_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaapPreferredStockSharesOutstanding_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="loc_us-gaapPreferredStockLiquidationPreferenceValue_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaapCommonStockParOrStatedValuePerShare_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaapCommonStockSharesAuthorized_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaapCommonStockSharesIssued_70"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaapCommonStockSharesOutstanding_70"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StatementsOfOperations" xlink:title="00000004 - Statement - Consolidated Statements of Operations"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StatementOfStockholdersEquity" xlink:title="00000005 - Statement - Consolidated Statement of Stockholders' Equity">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaapStatementEquityComponentsAxis"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaapEquityComponentDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapStatementEquityComponentsAxis" xlink:to="loc_us-gaapEquityComponentDomain" xlink:type="arc" order="20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaapEquityComponentDomain_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapStatementEquityComponentsAxis" xlink:to="loc_us-gaapEquityComponentDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaapCommonStockMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapEquityComponentDomain" xlink:to="loc_us-gaapCommonStockMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaapPreferredStockMember_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapEquityComponentDomain" xlink:to="loc_us-gaapPreferredStockMember_10" xlink:type="arc" order="11"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaapAdditionalPaidInCapitalMember_20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapEquityComponentDomain" xlink:to="loc_us-gaapAdditionalPaidInCapitalMember_20" xlink:type="arc" order="21"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaapRetainedEarningsMember_30"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapEquityComponentDomain" xlink:to="loc_us-gaapRetainedEarningsMember_30" xlink:type="arc" order="31"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity_60"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaapAdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_60"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockDividend" xlink:label="loc_us-gaapStockIssuedDuringPeriodValueStockDividend_60"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss_60"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StatementsOfCashFlows" xlink:title="00000006 - Statement - Consolidated Statements of Cash Flows"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/NatureOfBusiness" xlink:title="00000007 - Disclosure - Business Activity"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="00000008 - Disclosure - Summary of Significant Accounting Policies"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/NewAccountingStandards" xlink:title="00000009 - Disclosure - New Accounting Standards"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/FairValueMeasurements" xlink:title="00000010 - Disclosure - Fair Value Measurements"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/PropertyAndEquipment" xlink:title="00000011 - Disclosure - Property and Equipment"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IntangibleAssets" xlink:title="00000012 - Disclosure - Intangible Assets"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-it" xlink:title="00000013 - Disclosure - Income Taxes"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/NotesPayable" xlink:title="00000014 - Disclosure - Notes Payable"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Disclosure-CommonStock" xlink:title="00000015 - Disclosure - Stockholders' Equity and Warrants"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Stock-basedCompensation" xlink:title="00000016 - Disclosure - Stock-Based Compensation"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/CommitmentsAndContingencies" xlink:title="00000017 - Disclosure - Commitments and Contingencies"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/RelatedPartiesAndTransactions" xlink:title="00000018 - Disclosure - Related Parties and Transactions"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Concentrations" xlink:title="00000019 - Disclosure - Concentrations"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/LiquidityAndGoingConcern" xlink:title="00000020 - Disclosure - Liquidity and Going Concern"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-se" xlink:title="00000021 - Disclosure - Subsequent Events"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-soapadobp" xlink:title="00000022 - Disclosure - Summary of Significant Accounting Policies (Policies)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/FairValueMeasurementsTables" xlink:title="00000023 - Disclosure - Fair Value Measurements (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/PropertyAndEquipmentTables" xlink:title="00000024 - Disclosure - Property and Equipment (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IntangibleAssetsTables" xlink:title="00000025 - Disclosure - Intangible Assets (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-itt" xlink:title="00000026 - Disclosure - Income Taxes (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsTables" xlink:title="00000027 - Disclosure - Stockholders' Equity and Warrants (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationTables" xlink:title="00000028 - Disclosure - Stock-Based Compensation (Tables)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/BusinessActivityDetails" xlink:title="00000029 - Disclosure - Business Activity (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesOtherDetails" xlink:title="00000030 - Disclosure - Summary of Significant Accounting Policies (Other) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesPropertyAndEquipmentDetails" xlink:title="00000031 - Disclosure - Summary of Significant Accounting Policies (Property and Equipment) (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaapPropertyPlantAndEquipmentLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaapScheduleOfPropertyPlantAndEquipmentTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapPropertyPlantAndEquipmentLineItems" xlink:to="loc_us-gaapScheduleOfPropertyPlantAndEquipmentTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis" xlink:label="loc_srtRangeAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapScheduleOfPropertyPlantAndEquipmentTable" xlink:to="loc_srtRangeAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember" xlink:label="loc_srtRangeMember"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srtRangeAxis" xlink:to="loc_srtRangeMember" xlink:type="arc" order="20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember" xlink:label="loc_srtRangeMember_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_srtRangeAxis" xlink:to="loc_srtRangeMember_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember" xlink:label="loc_srtMinimumMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srtRangeMember" xlink:to="loc_srtMinimumMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember" xlink:label="loc_srtMaximumMember_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srtRangeMember" xlink:to="loc_srtMaximumMember_10" xlink:type="arc" order="11"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaapPropertyPlantAndEquipmentUsefulLife_30"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapPropertyPlantAndEquipmentLineItems" xlink:to="loc_us-gaapPropertyPlantAndEquipmentUsefulLife_30" xlink:type="arc" order="0"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesIntangilbeAssetsDetails" xlink:title="00000032 - Disclosure - Summary of Significant Accounting Policies (Intangilbe Assets) (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaapScheduleOfFiniteLivedIntangibleAssetsTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapScheduleOfFiniteLivedIntangibleAssetsTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsByMajorClassAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapScheduleOfFiniteLivedIntangibleAssetsTable" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsByMajorClassAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsMajorClassNameDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:type="arc" order="20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsMajorClassNameDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PatentsMember" xlink:label="loc_us-gaapPatentsMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="loc_us-gaapPatentsMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_40" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaapImpairmentOfIntangibleAssetsExcludingGoodwill_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAcquiredFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapImpairmentOfIntangibleAssetsExcludingGoodwill_40" xlink:type="arc" order="1"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/SummaryOfSignificantAccountingPoliciesNetLossPerCommonShareDetails" xlink:title="00000033 - Disclosure - Summary of Significant Accounting Policies (Net Loss Per Common Share) (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaapScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:to="loc_us-gaapScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:to="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaapAntidilutiveSecuritiesNameDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:to="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:type="arc" order="20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:to="loc_us-gaapAntidilutiveSecuritiesNameDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaapConvertibleDebtSecuritiesMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_us-gaapConvertibleDebtSecuritiesMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaapEmployeeStockOptionMember_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_us-gaapEmployeeStockOptionMember_10" xlink:type="arc" order="11"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_CommonStockAndWarrantsMember" xlink:label="loc_fnamCommonStockAndWarrantsMember_20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_fnamCommonStockAndWarrantsMember_20" xlink:type="arc" order="21"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_us-gaapSeriesAPreferredStockMember_30" xlink:type="arc" order="31"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_SeriesA2PreferredStockMember" xlink:label="loc_fnamSeriesA2PreferredStockMember_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_fnamSeriesA2PreferredStockMember_40" xlink:type="arc" order="41"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_80"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:to="loc_us-gaapAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_80" xlink:type="arc" order="0"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/FairValueMeasurementsDetails" xlink:title="00000034 - Disclosure - Fair Value Measurements (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:to="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaapFairValueByFairValueHierarchyLevelAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:to="loc_us-gaapFairValueByFairValueHierarchyLevelAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaapFairValueMeasurementsFairValueHierarchyDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapFairValueByFairValueHierarchyLevelAxis" xlink:to="loc_us-gaapFairValueMeasurementsFairValueHierarchyDomain" xlink:type="arc" order="20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapFairValueByFairValueHierarchyLevelAxis" xlink:to="loc_us-gaapFairValueMeasurementsFairValueHierarchyDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaapFairValueInputsLevel1Member_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFairValueMeasurementsFairValueHierarchyDomain" xlink:to="loc_us-gaapFairValueInputsLevel1Member_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaapFairValueInputsLevel2Member_10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaapFairValueInputsLevel3Member_20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Investments" xlink:label="loc_us-gaapInvestments_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:to="loc_us-gaapInvestments_60" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaapAssetsFairValueDisclosure_60"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments" xlink:label="loc_us-gaapUnrealizedGainLossOnInvestments_60"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/PropertyAndEquipmentDetails" xlink:title="00000035 - Disclosure - Property and Equipment (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaapPropertyPlantAndEquipmentByTypeAxis"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaapPropertyPlantAndEquipmentTypeDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapPropertyPlantAndEquipmentByTypeAxis" xlink:to="loc_us-gaapPropertyPlantAndEquipmentTypeDomain" xlink:type="arc" order="20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapPropertyPlantAndEquipmentByTypeAxis" xlink:to="loc_us-gaapPropertyPlantAndEquipmentTypeDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaapEquipmentMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapPropertyPlantAndEquipmentTypeDomain" xlink:to="loc_us-gaapEquipmentMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember" xlink:label="loc_us-gaapSoftwareAndSoftwareDevelopmentCostsMember_10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaapFurnitureAndFixturesMember_20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaapPropertyPlantAndEquipmentGross_110"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_110"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapPropertyPlantAndEquipmentLineItems" xlink:to="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_110" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaapDepreciation_110"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IntangibleAssetsDetails" xlink:title="00000036 - Disclosure - Intangible Assets (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsLineItems"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapScheduleOfFiniteLivedIntangibleAssetsTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaapInProcessResearchAndDevelopmentMember_0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PatentsMember" xlink:label="loc_us-gaapPatentsMember_10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsGross_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsGross_90" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAccumulatedAmortization_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentForAmortization" xlink:label="loc_us-gaapAdjustmentForAmortization_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_us-gaapAdjustmentForAmortization_90" xlink:type="arc" order="3"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_AdditionalExpectedCostsToCompleteResearch" xlink:label="loc_fnamAdditionalExpectedCostsToCompleteResearch_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapFiniteLivedIntangibleAssetsLineItems" xlink:to="loc_fnamAdditionalExpectedCostsToCompleteResearch_90" xlink:type="arc" order="4"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseYearThree_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseYearFour_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseYearFive_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_90"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IncomeTaxesNarrativeDetails" xlink:title="00000037 - Disclosure - Income Taxes (Narrative) (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaapOperatingLossCarryforwardsLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaapOperatingLossCarryforwardsTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_us-gaapOperatingLossCarryforwardsTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis" xlink:label="loc_srtRangeAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapOperatingLossCarryforwardsTable" xlink:to="loc_srtRangeAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember" xlink:label="loc_srtRangeMember"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srtRangeAxis" xlink:to="loc_srtRangeMember" xlink:type="arc" order="20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember" xlink:label="loc_srtRangeMember_10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember" xlink:label="loc_srtMaximumMember_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srtRangeMember" xlink:to="loc_srtMaximumMember_40" xlink:type="arc" order="41"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_FutureFederalStatutoryTaxRate" xlink:label="loc_fnamFutureFederalStatutoryTaxRate_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_fnamFutureFederalStatutoryTaxRate_60" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="loc_us-gaapValuationAllowanceDeferredTaxAssetChangeInAmount_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_us-gaapValuationAllowanceDeferredTaxAssetChangeInAmount_60" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaapOperatingLossCarryforwards_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_us-gaapOperatingLossCarryforwards_60" xlink:type="arc" order="2"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaapTaxCreditCarryforwardAmount_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_us-gaapTaxCreditCarryforwardAmount_60" xlink:type="arc" order="3"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLossCarryforwardsExpirationDate" xlink:label="loc_us-gaapOperatingLossCarryforwardsExpirationDate_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapOperatingLossCarryforwardsLineItems" xlink:to="loc_us-gaapOperatingLossCarryforwardsExpirationDate_60" xlink:type="arc" order="4"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IncomeTaxesScheduleOfIncomeTaxExpenseDetails" xlink:title="00000038 - Disclosure - Income Taxes (Schedule of Income Tax Expense) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/fnam-ititrd" xlink:title="00000039 - Disclosure - Income Taxes (Income Tax Reconciliation) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:title="00000040 - Disclosure - Income Taxes (Schedule of Deferred Tax Assets and Liabilities) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/NotesPayableDetails" xlink:title="00000041 - Disclosure - Notes Payable (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaapDebtInstrumentAxis"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaapDebtInstrumentNameDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapDebtInstrumentAxis" xlink:to="loc_us-gaapDebtInstrumentNameDomain" xlink:type="arc" order="20"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaapDebtInstrumentNameDomain_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapDebtInstrumentAxis" xlink:to="loc_us-gaapDebtInstrumentNameDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_SBAPaycheckProtectionProgramMember" xlink:label="loc_fnamSBAPaycheckProtectionProgramMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapDebtInstrumentNameDomain" xlink:to="loc_fnamSBAPaycheckProtectionProgramMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_EconomicInjuryDisasterLoanMember" xlink:label="loc_fnamEconomicInjuryDisasterLoanMember_10"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapDebtInstrumentNameDomain" xlink:to="loc_fnamEconomicInjuryDisasterLoanMember_10" xlink:type="arc" order="11"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_DCADoleMember" xlink:label="loc_fnamDCADoleMember_20"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_ResearchAgreementUniversityOfWisconsinMadisonMember" xlink:label="loc_fnamResearchAgreementUniversityOfWisconsinMadisonMember_30"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapDebtInstrumentNameDomain" xlink:to="loc_fnamResearchAgreementUniversityOfWisconsinMadisonMember_30" xlink:type="arc" order="31"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_EIDLProgramMember" xlink:label="loc_fnamEIDLProgramMember_50"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapDebtInstrumentNameDomain" xlink:to="loc_fnamEIDLProgramMember_50" xlink:type="arc" order="51"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromNotesPayable" xlink:label="loc_us-gaapProceedsFromNotesPayable_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentPeriodicPayment" xlink:label="loc_us-gaapDebtInstrumentPeriodicPayment_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaapDebtInstrumentInterestRateStatedPercentage_90"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPayableCurrent" xlink:label="loc_us-gaapInterestPayableCurrent_90"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_PaymentToCompanyUponExecution" xlink:label="loc_fnamPaymentToCompanyUponExecution_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamPaymentToCompanyUponExecution_90" xlink:type="arc" order="4"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_PaymentToCompanyByTwelveMonthAnniversary" xlink:label="loc_fnamPaymentToCompanyByTwelveMonthAnniversary_90"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_PaymentToCompanyByThirtySxMonthAnniversary" xlink:label="loc_fnamPaymentToCompanyByThirtySxMonthAnniversary_90"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_PaymentToCompanyByFortyEightMonthAnniversary" xlink:label="loc_fnamPaymentToCompanyByFortyEightMonthAnniversary_90"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_ReimbursedCostsIncurred" xlink:label="loc_fnamReimbursedCostsIncurred_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamReimbursedCostsIncurred_90" xlink:type="arc" order="8"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_ExpectedPaymentsToUnversityOfWisconsinMadisonTwoYearTerm" xlink:label="loc_fnamExpectedPaymentsToUnversityOfWisconsinMadisonTwoYearTerm_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamExpectedPaymentsToUnversityOfWisconsinMadisonTwoYearTerm_90" xlink:type="arc" order="9"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_ExpectedFieldTrialCosts" xlink:label="loc_fnamExpectedFieldTrialCosts_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamExpectedFieldTrialCosts_90" xlink:type="arc" order="10"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_NotesPayableForDoleFunding" xlink:label="loc_fnamNotesPayableForDoleFunding_90"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamNotesPayableForDoleFunding_90" xlink:type="arc" order="11"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsNarrativeDetails" xlink:title="00000042 - Disclosure - Stockholders' Equity and Warrants (Narrative) (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaapClassOfStockLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaapScheduleOfStockByClassTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapScheduleOfStockByClassTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapScheduleOfStockByClassTable" xlink:to="loc_us-gaapStatementClassOfStockAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaapClassOfStockDomain_10"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertiblePreferredStockMember" xlink:label="loc_us-gaapConvertiblePreferredStockMember_30"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockDomain" xlink:to="loc_us-gaapConvertiblePreferredStockMember_30" xlink:type="arc" order="31"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_ConvertiblePreferredStockSeriesA2Member" xlink:label="loc_fnamConvertiblePreferredStockSeriesA2Member_40"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockDomain" xlink:to="loc_fnamConvertiblePreferredStockSeriesA2Member_40" xlink:type="arc" order="41"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_SeriesA2PreferredStockMember" xlink:label="loc_fnamSeriesA2PreferredStockMember_70"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_CapitalStockSharesAuthorized" xlink:label="loc_fnamCapitalStockSharesAuthorized_120"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_fnamCapitalStockSharesAuthorized_120" xlink:type="arc" order="0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapCommonStockSharesAuthorized_120" xlink:type="arc" order="1"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapCommonStockParOrStatedValuePerShare_120" xlink:type="arc" order="2"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapPreferredStockSharesAuthorized_120" xlink:type="arc" order="3"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapPreferredStockParOrStatedValuePerShare_120" xlink:type="arc" order="4"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_StatedPerShareValueOfPreferredStock" xlink:label="loc_fnamStatedPerShareValueOfPreferredStock_120"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_fnamStatedPerShareValueOfPreferredStock_120" xlink:type="arc" order="5"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityLiquidationPreferencePerShare" xlink:label="loc_us-gaapTemporaryEquityLiquidationPreferencePerShare_120"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapTemporaryEquityLiquidationPreferencePerShare_120" xlink:type="arc" order="6"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_us-gaapPreferredStockDividendRatePercentage_120"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapPreferredStockDividendRatePercentage_120" xlink:type="arc" order="7"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaapDividendsPayableCurrent_120"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapClassOfStockLineItems" xlink:to="loc_us-gaapDividendsPayableCurrent_120" xlink:type="arc" order="8"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/StockholdersEquityAndWarrantsSummaryOfWarrantsActivityDetails" xlink:title="00000043 - Disclosure - Stockholders' Equity and Warrants (Summary of Warrants Activity) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationNarrativeDetails" xlink:title="00000044 - Disclosure - Stock-Based Compensation (Narrative) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/Stock-basedCompensationSummaryOfStockOptionsActivityDetails" xlink:title="00000045 - Disclosure - Stock-Based Compensation (Summary of Stock Options Activity) (Details)"/>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/CommitmentsAndContingenciesDetails" xlink:title="00000046 - Disclosure - Commitments and Contingencies (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaapDebtInstrumentAxis"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaapDebtInstrumentNameDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapDebtInstrumentNameDomain" xlink:to="loc_fnamResearchAgreementUniversityOfWisconsinMadisonMember_40" xlink:type="arc" order="41"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_MonthlyRentPayment" xlink:label="loc_fnamMonthlyRentPayment_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamMonthlyRentPayment_60" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_MinimumLeaseCommitment" xlink:label="loc_fnamMinimumLeaseCommitment_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamMinimumLeaseCommitment_60" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_us-gaapLeaseAndRentalExpense_60"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_TotalAmountOfGrantRevenueRecognizedToDate" xlink:label="loc_fnamTotalAmountOfGrantRevenueRecognizedToDate_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamTotalAmountOfGrantRevenueRecognizedToDate_60" xlink:type="arc" order="3"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_TotalPossibleFutureRoyaltiesOwed" xlink:label="loc_fnamTotalPossibleFutureRoyaltiesOwed_60"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_fnamTotalPossibleFutureRoyaltiesOwed_60" xlink:type="arc" order="4"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/RelatedPartiesAndTransactionsDetails" xlink:title="00000047 - Disclosure - Related Parties and Transactions (Details)">

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaapRelatedPartyTransactionLineItems"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaapScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xbrldt:contextElement="segment" xlink:from="loc_us-gaapRelatedPartyTransactionLineItems" xlink:to="loc_us-gaapScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:type="arc" order="10" xbrldt:closed="true"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaapRelatedPartyTransactionAxis"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="loc_us-gaapRelatedPartyTransactionAxis" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaapRelatedPartyTransactionDomain"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapRelatedPartyTransactionAxis" xlink:to="loc_us-gaapRelatedPartyTransactionDomain" xlink:type="arc" order="20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xbrldt:contextElement="segment" xlink:from="loc_us-gaapRelatedPartyTransactionAxis" xlink:to="loc_us-gaapRelatedPartyTransactionDomain_10" xlink:type="arc" order="30"/>

<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ChiefExecutiveOfficerMember" xlink:label="loc_srtChiefExecutiveOfficerMember_0"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapRelatedPartyTransactionDomain" xlink:to="loc_srtChiefExecutiveOfficerMember_0" xlink:type="arc" order="1"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_NumberOfCommonStockOutstandingOwnedByRelatedPartyShares" xlink:label="loc_fnamNumberOfCommonStockOutstandingOwnedByRelatedPartyShares_20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapRelatedPartyTransactionLineItems" xlink:to="loc_fnamNumberOfCommonStockOutstandingOwnedByRelatedPartyShares_20" xlink:type="arc" order="0"/>

<link:loc xlink:type="locator" xlink:href="fnam-20201231.xsd#fnam_PercentageOfCommonStockSharesOutstandingOwnedByRelatedParty" xlink:label="loc_fnamPercentageOfCommonStockSharesOutstandingOwnedByRelatedParty_20"/>

<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapRelatedPartyTransactionLineItems" xlink:to="loc_fnamPercentageOfCommonStockSharesOutstandingOwnedByRelatedParty_20" xlink:type="arc" order="1"/>

</link:definitionLink>

<link:definitionLink xlink:type="extended" xlink:role="http://evolutionarygenomicsinc.com/role/LiquidityAndGoingConcernDetails" xlink:title="00000048 - Disclosure - Liquidity and Going Concern (Details)"/>

</link:linkbase>

12 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/13/20  Evolutionary Genomics, Inc.       10-Q        9/30/20   57:30M                                    Edgar Filing LLC/FA
 3/30/20  Evolutionary Genomics, Inc.       10-K       12/31/19   61:4.4M                                   Edgar Filing LLC/FA
 4/01/19  Evolutionary Genomics, Inc.       10-K       12/31/18   61:29M                                    Edgar Filing LLC/FA
 3/05/18  Evolutionary Genomics, Inc.       10-K       12/31/17   59:3M                                     Edgar Filing LLC/FA
 2/10/17  Evolutionary Genomics, Inc.       10-K       12/31/16   66:3.8M                                   Edgar Filing LLC/FA
 2/25/16  Evolutionary Genomics, Inc.       8-K:3,5,9   2/22/16    3:136K                                   Edgar Filing LLC/FA
 2/19/16  Evolutionary Genomics, Inc.       10-K       12/31/15   63:6.2M                                   Edgar Filing LLC/FA
10/23/15  Evolutionary Genomics, Inc.       8-K:2,3,4,510/19/15    7:265K                                   Edgar Filing LLC/FA
 7/02/15  Evolutionary Genomics, Inc.       S-4/A                 41:10M                                    Edgar Filing LLC/FA
 4/02/15  Evolutionary Genomics, Inc.       S-4                   36:3.3M                                   Edgar Filing LLC/FA
 3/05/15  Evolutionary Genomics, Inc.       10-K       12/31/14   35:2.1M                                   Edgar Filing LLC/FA
 9/23/10  Evolutionary Genomics, Inc.       10-12G      9/24/10    6:143K                                   Precision Edgar/FA

↑Top

Filing Submission 0001553350-21-000252 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Evolutionary Genomics, Inc. – ‘10-K’ for 12/31/20 – ‘EX-101.DEF’

On: Wednesday, 3/31/21, at 11:31am ET · For: 12/31/20 · Accession #: 1553350-21-252 · File #: 0-54129

Annual Report — Form 10-KFiling Table of Contents

‘EX-101.DEF’ — XBRL Definitions — fnam-20201231_def

This Exhibit is an XBRL XML File.

12 Previous Filings that this Filing References

Annual Report — Form 10-K
Filing Table of Contents