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Opko Health, Inc. – ‘10-K’ for 12/31/23 – ‘EX-101.SCH’

On:  Friday, 3/1/24, at 4:07pm ET   ·   For:  12/31/23   ·   Accession #:  1437749-24-6285   ·   File #:  1-33528

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/01/24  Opko Health, Inc.                 10-K       12/31/23  122:18M                                    RDG Filings/FA

Annual Report   —   Form 10-K   —   SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   3.72M 
 2: EX-21.0     Subsidiaries List                                   HTML     36K 
 3: EX-23.1     Consent of Expert or Counsel                        HTML     35K 
 8: EX-97.1     Clawback Policy re: Recovery of Erroneously         HTML     70K 
                Awarded Compensation                                             
 4: EX-31.1     Certification -- §302 - SOA'02                      HTML     38K 
 5: EX-31.2     Certification -- §302 - SOA'02                      HTML     38K 
 6: EX-32.1     Certification -- §906 - SOA'02                      HTML     34K 
 7: EX-32.2     Certification -- §906 - SOA'02                      HTML     34K 
14: R1          Document And Entity Information                     HTML    103K 
15: R2          Consolidated Balance Sheets                         HTML    149K 
16: R3          Consolidated Balance Sheets (Parentheticals)        HTML     40K 
17: R4          Consolidated Statements of Operations               HTML    118K 
18: R5          Consolidated Statements of Comprehensive Income     HTML     54K 
                (Loss)                                                           
19: R6          Consolidated Statements of Equity                   HTML     94K 
20: R7          Consolidated Statements of Cash Flows               HTML    159K 
21: R8          Note 1 - Business and Organization                  HTML     45K 
22: R9          Note 2 - Foreign Exchange Rates                     HTML     37K 
23: R10         Note 3 - Summary of Significant Accounting          HTML     83K 
                Policies                                                         
24: R11         Note 4 - Income (Loss) Per Share                    HTML     40K 
25: R12         Note 5 - Acquisitions and Investments               HTML     84K 
26: R13         Note 6 - Composition of Certain Financial           HTML    198K 
                Statement Captions                                               
27: R14         Note 7 - Debt                                       HTML    123K 
28: R15         Note 8 - Shareholders' Equity                       HTML     44K 
29: R16         Note 9 - Accumulated Other Comprehensive (Loss)     HTML     44K 
30: R17         Note 10 - Equity-based Compensation                 HTML     94K 
31: R18         Note 11 - Income Taxes                              HTML    136K 
32: R19         Note 12 - Related Party Transactions                HTML     46K 
33: R20         Note 13 - Employee Benefit Plans                    HTML     39K 
34: R21         Note 14 - Commitments and Contingencies             HTML     51K 
35: R22         Note 15 - Revenue Recognition                       HTML    114K 
36: R23         Note 16 - Strategic Alliances                       HTML     71K 
37: R24         Note 17 - Leases                                    HTML     76K 
38: R25         Note 18 - Segments                                  HTML    109K 
39: R26         Note 19 - Fair Value Measurements                   HTML    122K 
40: R27         Note 20 - Derivative Contracts                      HTML     51K 
41: R28         Note 21 - Selected Quarterly Financial Data         HTML     54K 
                (Unaudited)                                                      
42: R29         Note 22 - Subsequent Events                         HTML     48K 
43: R30         Insider Trading Arrangements                        HTML     42K 
44: R31         Schedule I - Condensed Financial Information of     HTML    216K 
                Registrant                                                       
45: R32         Significant Accounting Policies (Policies)          HTML    141K 
46: R33         Note 5 - Acquisitions and Investments (Tables)      HTML     69K 
47: R34         Note 6 - Composition of Certain Financial           HTML    202K 
                Statement Captions (Tables)                                      
48: R35         Note 7 - Debt (Tables)                              HTML     99K 
49: R36         Note 9 - Accumulated Other Comprehensive (Loss)     HTML     42K 
                (Tables)                                                         
50: R37         Note 10 - Equity-based Compensation (Tables)        HTML     87K 
51: R38         Note 11 - Income Taxes (Tables)                     HTML    128K 
52: R39         Note 15 - Revenue Recognition (Tables)              HTML     89K 
53: R40         Note 17 - Leases (Tables)                           HTML     74K 
54: R41         Note 18 - Segments (Tables)                         HTML    108K 
55: R42         Note 19 - Fair Value Measurements (Tables)          HTML    120K 
56: R43         Note 20 - Derivative Contracts (Tables)             HTML     51K 
57: R44         Note 21 - Selected Quarterly Financial Data         HTML     54K 
                (Unaudited) (Tables)                                             
58: R45         Schedule I - Condensed Financial Information of     HTML    239K 
                Registrant (Tables)                                              
59: R46         Note 1 - Business and Organization (Details         HTML     60K 
                Textual)                                                         
60: R47         Note 2 - Foreign Exchange Rates (Details Textual)   HTML     49K 
61: R48         Note 3 - Summary of Significant Accounting          HTML    154K 
                Policies (Details Textual)                                       
62: R49         Note 4 - Income (Loss) Per Share (Details Textual)  HTML     50K 
63: R50         Note 5 - Acquisitions and Investments (Details      HTML    206K 
                Textual)                                                         
64: R51         Note 5 - Acquisitions and Investments - Purchase    HTML     55K 
                Price Allocation (Details)                                       
65: R52         Note 5 - Acquisitions and Investments - Schedule    HTML     51K 
                of Investments (Details)                                         
66: R53         Note 5 - Acquisitions and Investments - Gains and   HTML     39K 
                Losses on Equity Securities (Details)                            
67: R54         Note 6 - Composition of Certain Financial           HTML     58K 
                Statement Captions (Details Textual)                             
68: R55         Note 6 - Composition of Certain Financial           HTML    152K 
                Statement Captions - Schedule of Financial                       
                Statement Information (Details)                                  
69: R56         Note 6 - Composition of Certain Financial           HTML     49K 
                Statement Captions - Summary of Allowance for                    
                Doubtful Accounts, Inventory Reserve and Tax                     
                Valuation Allowance (Details)                                    
70: R57         Note 6 - Composition of Certain Financial           HTML     82K 
                Statement Captions - Schedule of Goodwill                        
                (Details)                                                        
71: R58         Note 7 - Debt (Details Textual)                     HTML    253K 
72: R59         Note 7 - Debt - Schedule of Debt (Details)          HTML     53K 
73: R60         Note 7 - Debt - Schedule of Debt Instruments        HTML     55K 
                (Details)                                                        
74: R61         Note 7 - Debt - Schedule of Line of Credit          HTML     70K 
                Facilities (Details)                                             
75: R62         Note 8 - Shareholders' Equity (Details Textual)     HTML     57K 
76: R63         Note 9 - Accumulated Other Comprehensive Loss -     HTML     44K 
                Changed in Accumulated Other Comprehensive Loss                  
                (Details)                                                        
77: R64         Note 10 - Equity-based Compensation (Details        HTML     83K 
                Textual)                                                         
78: R65         Note 10 - Equity-based Compensation - Schedule of   HTML     49K 
                Valuation Assumptions (Details)                                  
79: R66         Note 10 - Equity-based Compensation - Summary of    HTML     83K 
                Stock Option Activity (Details)                                  
80: R67         Note 10 - Equity-based Compensation - Summary of    HTML     51K 
                Restricted Stock Units (Details)                                 
81: R68         Note 11 - Income Taxes (Details Textual)            HTML     71K 
82: R69         Note 11 - Income Taxes - Components of Income Tax   HTML     58K 
                Expense (Details)                                                
83: R70         Note 11 - Income Taxes - Schedule of Deferred Tax   HTML     88K 
                Assets and Liabilities (Details)                                 
84: R71         Note 11 - Income Taxes - Schedule of Unrecognized   HTML     43K 
                Tax Benefits (Details)                                           
85: R72         Note 11 - Income Taxes - Reconciliation of          HTML     77K 
                Effective Income Tax Rate (Details)                              
86: R73         Note 11 - Income Taxes - Income Loss Before Income  HTML     39K 
                Taxes (Details)                                                  
87: R74         Note 12 - Related Party Transactions (Details       HTML    128K 
                Textual)                                                         
88: R75         Note 13 - Employee Benefit Plans (Details Textual)  HTML     40K 
89: R76         Note 14 - Commitments and Contingencies (Details    HTML     60K 
                Textual)                                                         
90: R77         Note 15 - Revenue Recognition (Details Textual)     HTML     79K 
91: R78         Note 15 - Revenue Recognition - Composition of      HTML     50K 
                Revenue From Services (Details)                                  
92: R79         Note 15 - Revenue Recognition - Analysis of         HTML     64K 
                Product Sales Allowances and Accruals (Details)                  
93: R80         Note 15 - Revenue Recognition - Changes in          HTML     36K 
                Contractual Liabilities (Details)                                
94: R81         Note 16 - Strategic Alliances (Details Textual)     HTML    162K 
95: R82         Note 17 - Leases (Details Textual)                  HTML     50K 
96: R83         Note 17 - Leases - Lease Balances (Details)         HTML     58K 
97: R84         Note 17 - Leases - Undiscounted Future Minimum      HTML     70K 
                Lease Payments (Details)                                         
98: R85         Note 17 - Leases - Supplemental Cash Flow           HTML     40K 
                Information (Details)                                            
99: R86         Note 18 - Segments (Details Textual)                HTML     54K 
100: R87         Note 18 - Segments - Operations by Segment          HTML     94K  
                (Details)                                                        
101: R88         Note 18 - Segments - Assets by Segment (Details)    HTML     51K  
102: R89         Note 18 - Segments - Long-lived Assets by Segment   HTML     38K  
                (Details)                                                        
103: R90         Note 19 - Fair Value Measurements (Details          HTML     38K  
                Textual)                                                         
104: R91         Note 19 - Fair Value Measurements - Financial       HTML     79K  
                Assets and Liabilities Measured on a Recurring                   
                Basis (Details)                                                  
105: R92         Note 19 - Fair Value Measurements - Carrying Value  HTML     43K  
                and Estimated Fair Value of Notes (Details)                      
106: R93         Note 19 - Fair Value Measurements - Reconciliation  HTML     39K  
                of Level 3 Liabilities (Details)                                 
107: R94         Note 20 - Derivative Contracts - Summary of Fair    HTML     40K  
                Values and Presentation of Derivatives Financial                 
                Instruments (Details)                                            
108: R95         Note 20 - Derivative Contracts - Summary of Gains   HTML     38K  
                and Losses Recorded (Details)                                    
109: R96         Note 21 - Selected Quarterly Financial Data         HTML     59K  
                (Unaudited) - Summary of Selected Quarterly                      
                Financial Data (Details)                                         
110: R97         Note 22 - Subsequent Events (Details Textual)       HTML    109K  
111: R98         Schedule I - Condensed Financial Information of     HTML    376K  
                Registrant (Details Textual)                                     
112: R99         Schedule I - Parent Company Condensed Balance       HTML    151K  
                Sheets (Details)                                                 
113: R100        Schedule I - Parent Company Condensed Balance       HTML     43K  
                Sheets (Details) (Parentheticals)                                
114: R101        Schedule I - Parent Company Condensed Statements    HTML    113K  
                of Income (Details)                                              
115: R102        Schedule I - Parent Company Condensed Statements    HTML     58K  
                of Comprehensive Income (Details)                                
116: R103        Schedule I - Parent Company Condensed Statements    HTML    143K  
                of Cash Flows (Details)                                          
117: R104        Schedule I - Schedule of Debt Instruments           HTML     51K  
                (Details)                                                        
119: XML         IDEA XML File -- Filing Summary                      XML    231K  
122: XML         XBRL Instance -- opk20231231_10k_htm                 XML   4.71M  
118: EXCEL       IDEA Workbook of Financial Report Info              XLSX    290K  
10: EX-101.CAL  XBRL Calculations -- opk-20231231_cal                XML    352K 
11: EX-101.DEF  XBRL Definitions -- opk-20231231_def                 XML   3.02M 
12: EX-101.LAB  XBRL Labels -- opk-20231231_lab                      XML   2.05M 
13: EX-101.PRE  XBRL Presentations -- opk-20231231_pre               XML   3.03M 
 9: EX-101.SCH  XBRL Schema -- opk-20231231                          XSD    345K 
120: JSON        XBRL Instance as JSON Data -- MetaLinks              814±  1.34M  
121: ZIP         XBRL Zipped Folder -- 0001437749-24-006285-xbrl      Zip    769K  


‘EX-101.SCH’   —   XBRL Schema — opk-20231231


This Exhibit is an XBRL File.


                                                                                                                                                                                
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<xsd:element id="opk_AssetsAndLiabilitiesLesseeTableTextBlock" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_AutomobilesAndAircraftMember" name="AutomobilesAndAircraftMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BancoDeSabadellMember" name="BancoDeSabadellMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BankOfChileMember" name="BankOfChileMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BardaAgreementMember" name="BardaAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BciBankMember" name="BciBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BeckmanCoulterMember" name="BeckmanCoulterMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BiceBankMember" name="BiceBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BiocardiaMember" name="BiocardiaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_BioreferenceMember" name="BioreferenceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_BusinessAcquisitionOutstandingSharesHeldPercentage" name="BusinessAcquisitionOutstandingSharesHeldPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_BusinessCombinationAndInvestmentsDisclosureTextBlock" name="BusinessCombinationAndInvestmentsDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_BusinessCombinationContingentConsiderationArrangementsEarnoutPaymentShares" name="BusinessCombinationContingentConsiderationArrangementsEarnoutPaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedGoodwillAndIntangibleAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedGoodwillAndIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_BusinessDivestureMilestonePaymentShares" name="BusinessDivestureMilestonePaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CURNAOPKODiagnosticsAndOPKORenalMember" name="CURNAOPKODiagnosticsAndOPKORenalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_Camp4Member" name="Camp4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CapitalizedResearchAndDevelopmentInProcess" name="CapitalizedResearchAndDevelopmentInProcess" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CashUsedOrRepurchaseOfNotes" name="CashUsedOrRepurchaseOfNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_ChangesInFairValueGainLossInEquitySecuritiesFvniAndDerivativeInstruments" name="ChangesInFairValueGainLossInEquitySecuritiesFvniAndDerivativeInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ChargebacksDiscountsRebatesAndFeesMember" name="ChargebacksDiscountsRebatesAndFeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ChileanAndSpanishLinesOfCreditMember" name="ChileanAndSpanishLinesOfCreditMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ClientPayersMember" name="ClientPayersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CocpMember" name="CocpMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CocrystalPharmaIncMember" name="CocrystalPharmaIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeAgreementDelayedPayment" name="CollaborativeAgreementDelayedPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeAgreementDelayedPaymentReceivedCumulative" name="CollaborativeAgreementDelayedPaymentReceivedCumulative" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeAgreementOptionSalesMilestonePayments" name="CollaborativeAgreementOptionSalesMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeAgreementsEachMilestonePayment" name="CollaborativeAgreementsEachMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeArrangementDevelopmentCosts" name="CollaborativeArrangementDevelopmentCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementDevelopmentMilestonePayment" name="CollaborativeArrangementDevelopmentMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeArrangementDevelopmentMilestonePaymentShares" name="CollaborativeArrangementDevelopmentMilestonePaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementMaximumRegulatoryMilestonePayments" name="CollaborativeArrangementMaximumRegulatoryMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeArrangementPeriodFollowingFirstCommercialSale" name="CollaborativeArrangementPeriodFollowingFirstCommercialSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CollaborativeArrangementSalesMilestonePayment" name="CollaborativeArrangementSalesMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_CollaborativeArrangementUpfrontPaymentShares" name="CollaborativeArrangementUpfrontPaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CommonStockOptionsAndWarrantsNetExercised" name="CommonStockOptionsAndWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CommonStockOptionsWarrantsMember" name="CommonStockOptionsWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CommonStockVotingRightsVotes" name="CommonStockVotingRightsVotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_CommonwealthMember" name="CommonwealthMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ConsorcioBankMember" name="ConsorcioBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ConversionOfThe2025NotesIntoCommonStockMember" name="ConversionOfThe2025NotesIntoCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ConvertibleNotesMember" name="ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ConvertiblePreferredStockSharesDesignatedMaximum" name="ConvertiblePreferredStockSharesDesignatedMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ConvertibleSeniorNotesDue2025Member" name="ConvertibleSeniorNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CreditAgreementMember" name="CreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CurnaMember" name="CurnaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_CurrencyConcentrationRiskMember" name="CurrencyConcentrationRiskMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtConversionConvertedInstrumentSharesOutstanding" name="DebtConversionConvertedInstrumentSharesOutstanding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_DebtInstrumentAggregatePrincipleAmountPurchasedOnClosingDate" name="DebtInstrumentAggregatePrincipleAmountPurchasedOnClosingDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentBasisSpreadOnVariableRateBenchmarkAdjustment" name="DebtInstrumentBasisSpreadOnVariableRateBenchmarkAdjustment" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentConvertibleConversionPremiumPerShare" name="DebtInstrumentConvertibleConversionPremiumPerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentConvertibleConversionPremiumPercent" name="DebtInstrumentConvertibleConversionPremiumPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentConvertibleDebtIncreaseDecreaseInMaximumSharesIssuable" name="DebtInstrumentConvertibleDebtIncreaseDecreaseInMaximumSharesIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_DebtInstrumentConvertibleDebtMaximumSharesIssuable" name="DebtInstrumentConvertibleDebtMaximumSharesIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_DebtInstrumentOutstandingConvertibleNotes" name="DebtInstrumentOutstandingConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_DebtInstrumentUnpaidAccruedInterest" name="DebtInstrumentUnpaidAccruedInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_DeferredTaxAssetsCapitalizedResearchAndDevelopment" name="DeferredTaxAssetsCapitalizedResearchAndDevelopment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_DeferredTaxAssetsLeaseLiability" name="DeferredTaxAssetsLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance" name="DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_DeferredTaxAssetsOperatingLeaseAsset" name="DeferredTaxAssetsOperatingLeaseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_DevelopmentAndLicenseAgreementMember" name="DevelopmentAndLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DiagnosticsMember" name="DiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_DravetSyndromeProductsMember" name="DravetSyndromeProductsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationDeemedDividendPercent" name="EffectiveIncomeTaxRateReconciliationDeemedDividendPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationImputedInterestPercent" name="EffectiveIncomeTaxRateReconciliationImputedInterestPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent" name="EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueUpsPercent" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueUpsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActTransitionTaxOnAccumulatedForeignEarnings" name="EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActTransitionTaxOnAccumulatedForeignEarnings" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationTransferPricingAdjustmentsPercent" name="EffectiveIncomeTaxRateReconciliationTransferPricingAdjustmentsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" name="EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EirgenMember" name="EirgenMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EloxxPharmaceuticalsIncMember" name="EloxxPharmaceuticalsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_EquityIncentivePlan2007Member" name="EquityIncentivePlan2007Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_EquityInvestmentsCarryingValueOfEquityIntruments" name="EquityInvestmentsCarryingValueOfEquityIntruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquityMethodInvestmentExcludingVariableInterestEntity" name="EquityMethodInvestmentExcludingVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquityMethodInvestmentVariableInterestEntity" name="EquityMethodInvestmentVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquityMethodInvestmentVariableInterestEntityUnderlyingEquityInNetAssets" name="EquityMethodInvestmentVariableInterestEntityUnderlyingEquityInNetAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_EquitySecurityFvniOwnershipPercent" name="EquitySecurityFvniOwnershipPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_EstadoBankMember" name="EstadoBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyImpact" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FinetechMember" name="FinetechMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FirstMarketingApprovalOfRayaldeeInEuropeMember" name="FirstMarketingApprovalOfRayaldeeInEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_FullyVestedEquityAwardsMember" name="FullyVestedEquityAwardsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_GainLossOnConversionOfDebt" name="GainLossOnConversionOfDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GeneDxHoldingsCorpMember" name="GeneDxHoldingsCorpMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GeneDxHoldingsMember" name="GeneDxHoldingsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GeneDxLLCMember" name="GeneDxLLCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GeneDxMember" name="GeneDxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GermanyPriceApprovalByLocalSickFundAssociationMember" name="GermanyPriceApprovalByLocalSickFundAssociationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_GoodwillAcquiredDisposedOfDuringPeriod" name="GoodwillAcquiredDisposedOfDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GovernmentContractBardaMember" name="GovernmentContractBardaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GovernmentPayersMember" name="GovernmentPayersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_GovernmentalMember" name="GovernmentalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_HealthcareInsurersMember" name="HealthcareInsurersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_HealthsnapIncMember" name="HealthsnapIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_InCellDxMember" name="InCellDxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_IncomeLossFormSubsidiaries" name="IncomeLossFormSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncomeLossFromContinuingOperationsBeforeInvestmentsInInvesteesExtraordinaryItemsNetOfTax" name="IncomeLossFromContinuingOperationsBeforeInvestmentsInInvesteesExtraordinaryItemsNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments" name="IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncomeLossFromContinuingOperationsNetOfTaxBeforeEquityMethodInvestmentsAndNoncontrollingInterestTotal" name="IncomeLossFromContinuingOperationsNetOfTaxBeforeEquityMethodInvestmentsAndNoncontrollingInterestTotal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncreaseDecreaseInEquitySecuritiesFvniAndDerivativeInstruments" name="IncreaseDecreaseInEquitySecuritiesFvniAndDerivativeInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_IncreaseDecreaseInForeignCurrencyMeasurement" name="IncreaseDecreaseInForeignCurrencyMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_IndividualPatientsMember" name="IndividualPatientsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_IntegratedDNATechnologiesIncMember" name="IntegratedDNATechnologiesIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_InterestExpenseNonoperating" name="InterestExpenseNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_InterestIncomeNonoperating" name="InterestIncomeNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_InternacionalBankMember" name="InternacionalBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_InvestmentNetMember" name="InvestmentNetMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_InvestmentOwnedSharesPurchased" name="InvestmentOwnedSharesPurchased" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ItauBankMember" name="ItauBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_JPMorganChaseMember" name="JPMorganChaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LeaderMedJointVentureMember" name="LeaderMedJointVentureMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LeaderMedMember" name="LeaderMedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LeicaMicrosystemsIncMember" name="LeicaMicrosystemsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_LesseeLeaseLiabilityMaturityTableTextBlock" name="LesseeLeaseLiabilityMaturityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_LesseeLeasesTextBlock" name="LesseeLeasesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LicenseAgreementMember" name="LicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_LineOfCreditAndNotesAndLoansPayableCurrentMember" name="LineOfCreditAndNotesAndLoansPayableCurrentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_LitigationSettlementInterestRate" name="LitigationSettlementInterestRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_LondonInterbankOfferedRateMember" name="LondonInterbankOfferedRateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MachineryMedicalAndOtherEquipmentMember" name="MachineryMedicalAndOtherEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MedicareAndMedicaidMember" name="MedicareAndMedicaidMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MerckAgreementMember" name="MerckAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MerckSharpDohmeLLCMember" name="MerckSharpDohmeLLCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_MilestonePaymentsMember" name="MilestonePaymentsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_MinorityInterestSharesIssued" name="MinorityInterestSharesIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ModexTherapeuticsIncMember" name="ModexTherapeuticsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NeovascMember" name="NeovascMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NewCreditAgreementMember" name="NewCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NicoyaMacauLimitedMember" name="NicoyaMacauLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NimsMember" name="NimsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_NoncashRevenueFromTransferOfIntellectualProperty" name="NoncashRevenueFromTransferOfIntellectualProperty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NondravetSyndromeProductsMember" name="NondravetSyndromeProductsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NoninvasiveMonitoringSystemsIncMember" name="NoninvasiveMonitoringSystemsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NotesAndOtherDebtMember" name="NotesAndOtherDebtMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NotesPayableAndOtherLongTermLiabilitiesMember" name="NotesPayableAndOtherLongTermLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_NumberOfMajorCustomers" name="NumberOfMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OPKOHealthSavingsAndRetirementPlanMember" name="OPKOHealthSavingsAndRetirementPlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OfficeSpaceMember" name="OfficeSpaceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_OperatingLeaseMonthlyRentExpense" name="OperatingLeaseMonthlyRentExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearFive" name="OperatingLeasesMonthlyPaymentsYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearOne" name="OperatingLeasesMonthlyPaymentsYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_OpkoBiologicsMember" name="OpkoBiologicsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OpkoChileMember" name="OpkoChileMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OpkoDiagnosticsMember" name="OpkoDiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OpkoHealthEuropeMember" name="OpkoHealthEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OpkoMexicoMember" name="OpkoMexicoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_OptionsExercisedAndRestrictedStockUnitsSettledShares" name="OptionsExercisedAndRestrictedStockUnitsSettledShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_OwnershipPercentage" name="OwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_PaymentsForLeases" name="PaymentsForLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PfizerAgreementMember" name="PfizerAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PfizerIncMember" name="PfizerIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PharmaceuticalMember" name="PharmaceuticalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PharmsynthezMember" name="PharmsynthezMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ProceedsFromConvertibleDebtConversionFee" name="ProceedsFromConvertibleDebtConversionFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element id="opk_ProceedsFromRepurchaseOfStockOptionsAndWarrantsExercised" name="ProceedsFromRepurchaseOfStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ProjectRegistrationMember" name="ProjectRegistrationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_PropertyPlantAndEquipmentNetMember" name="PropertyPlantAndEquipmentNetMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ProvisionForSalesAllowanceAsPercentOfGrossSales" name="ProvisionForSalesAllowanceAsPercentOfGrossSales" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_QuarterlyAvailabilityIs50OrMoreMember" name="QuarterlyAvailabilityIs50OrMoreMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_QuarterlyAvailabilityIsLessThan50Member" name="QuarterlyAvailabilityIsLessThan50Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_RayaldeeMember" name="RayaldeeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ReclassificationFromInProcessResearchAndDevelopmentMember" name="ReclassificationFromInProcessResearchAndDevelopmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ReimbursementOfTravelExpensesMember" name="ReimbursementOfTravelExpensesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_RestrictedNetAssets" name="RestrictedNetAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element abstract="true" id="opk_RuenhuiBiopharmaceuticalsIncMember" name="RuenhuiBiopharmaceuticalsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SalesReturnsMember" name="SalesReturnsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SantanderBank2Member" name="SantanderBank2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SantanderBankMember" name="SantanderBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" name="ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_ScheduleOfSupplementalCashFlowInformationOfLeasesTableTextBlock" name="ScheduleOfSupplementalCashFlowInformationOfLeasesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ScotiabankMember" name="ScotiabankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SecuredOvernightFinancingRate12MonthsMember" name="SecuredOvernightFinancingRate12MonthsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SecurityBankMember" name="SecurityBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_SeriesA2PreferredStockMember" name="SeriesA2PreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ServicesRenderedMember" name="ServicesRenderedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_SharesIncludedInBusinessDivestureCashFlowImpact" name="SharesIncludedInBusinessDivestureCashFlowImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_ShippingAndHandlingCostsPolicyTextBlock" name="ShippingAndHandlingCostsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_StockIssuedAsPartOfAnAcquisitionCashFlowImpact" name="StockIssuedAsPartOfAnAcquisitionCashFlowImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element id="opk_StockIssuedDuringPeriodSharesOptionsExercisedAndRestrictedStockUnitsSettled" name="StockIssuedDuringPeriodSharesOptionsExercisedAndRestrictedStockUnitsSettled" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
<xsd:element id="opk_StockholdersEquityReverseStockSplitConversionPerShare" name="StockholdersEquityReverseStockSplitConversionPerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
<xsd:element id="opk_TaxCreditCarryforwardExpirationPeriod" name="TaxCreditCarryforwardExpirationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TaxYear2014ThroughTaxYear2020Member" name="TaxYear2014ThroughTaxYear2020Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TexasMedicaidOfficeMember" name="TexasMedicaidOfficeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_Th2029ConvertibleNotesMember" name="Th2029ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_The2023ConvertibleNotesMember" name="The2023ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_The2025NotesMember" name="The2025NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_The2029NotesMember" name="The2029NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_The2033SeniorNotesMember" name="The2033SeniorNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TransferOfIntellectualPropertyAndOtherMember" name="TransferOfIntellectualPropertyAndOtherMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TransitionServicesAgreementMember" name="TransitionServicesAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_TransitionTherapeuticsMember" name="TransitionTherapeuticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_VbiVaccinesIncMember" name="VbiVaccinesIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ViforFreseniusMedicalCareRenalPharmaLtdMember" name="ViforFreseniusMedicalCareRenalPharmaLtdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_XeneticMember" name="XeneticMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_ZebraMember" name="ZebraMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-schedule-of-valuation-assumptions-details" name="statement-statement-note-10-equitybased-compensation-schedule-of-valuation-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-summary-of-restricted-stock-units-details" name="statement-statement-note-10-equitybased-compensation-summary-of-restricted-stock-units-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-summary-of-stock-option-activity-details" name="statement-statement-note-10-equitybased-compensation-summary-of-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-tables" name="statement-statement-note-10-equitybased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-components-of-income-tax-expense-details" name="statement-statement-note-11-income-taxes-components-of-income-tax-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-income-loss-before-income-taxes-details" name="statement-statement-note-11-income-taxes-income-loss-before-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-reconciliation-of-effective-income-tax-rate-details" name="statement-statement-note-11-income-taxes-reconciliation-of-effective-income-tax-rate-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" name="statement-statement-note-11-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-schedule-of-unrecognized-tax-benefits-details" name="statement-statement-note-11-income-taxes-schedule-of-unrecognized-tax-benefits-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-tables" name="statement-statement-note-11-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-analysis-of-product-sales-allowances-and-accruals-details" name="statement-statement-note-15-revenue-recognition-analysis-of-product-sales-allowances-and-accruals-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-changes-in-contractual-liabilities-details" name="statement-statement-note-15-revenue-recognition-changes-in-contractual-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-composition-of-revenue-from-services-details" name="statement-statement-note-15-revenue-recognition-composition-of-revenue-from-services-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-tables" name="statement-statement-note-15-revenue-recognition-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-17-leases-lease-balances-details" name="statement-statement-note-17-leases-lease-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-17-leases-supplemental-cash-flow-information-details" name="statement-statement-note-17-leases-supplemental-cash-flow-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-17-leases-tables" name="statement-statement-note-17-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-17-leases-undiscounted-future-minimum-lease-payments-details" name="statement-statement-note-17-leases-undiscounted-future-minimum-lease-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-18-segments-assets-by-segment-details" name="statement-statement-note-18-segments-assets-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-18-segments-longlived-assets-by-segment-details" name="statement-statement-note-18-segments-longlived-assets-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-18-segments-operations-by-segment-details" name="statement-statement-note-18-segments-operations-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-18-segments-tables" name="statement-statement-note-18-segments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-carrying-value-and-estimated-fair-value-of-notes-details" name="statement-statement-note-19-fair-value-measurements-carrying-value-and-estimated-fair-value-of-notes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-financial-assets-and-liabilities-measured-on-a-recurring-basis-details" name="statement-statement-note-19-fair-value-measurements-financial-assets-and-liabilities-measured-on-a-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-reconciliation-of-level-3-liabilities-details" name="statement-statement-note-19-fair-value-measurements-reconciliation-of-level-3-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-tables" name="statement-statement-note-19-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-summary-of-fair-values-and-presentation-of-derivatives-financial-instruments-details" name="statement-statement-note-20-derivative-contracts-summary-of-fair-values-and-presentation-of-derivatives-financial-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-summary-of-gains-and-losses-recorded-details" name="statement-statement-note-20-derivative-contracts-summary-of-gains-and-losses-recorded-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-tables" name="statement-statement-note-20-derivative-contracts-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-21-selected-quarterly-financial-data-unaudited-summary-of-selected-quarterly-financial-data-details" name="statement-statement-note-21-selected-quarterly-financial-data-unaudited-summary-of-selected-quarterly-financial-data-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-21-selected-quarterly-financial-data-unaudited-tables" name="statement-statement-note-21-selected-quarterly-financial-data-unaudited-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-gains-and-losses-on-equity-securities-details" name="statement-statement-note-5-acquisitions-and-investments-gains-and-losses-on-equity-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-purchase-price-allocation-details" name="statement-statement-note-5-acquisitions-and-investments-purchase-price-allocation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-schedule-of-investments-details" name="statement-statement-note-5-acquisitions-and-investments-schedule-of-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-tables" name="statement-statement-note-5-acquisitions-and-investments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-financial-statement-information-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-financial-statement-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-goodwill-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-goodwill-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-summary-of-allowance-for-doubtful-accounts-inventory-reserve-and-tax-valuation-allowance-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-summary-of-allowance-for-doubtful-accounts-inventory-reserve-and-tax-valuation-allowance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-tables" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-debt-details" name="statement-statement-note-7-debt-schedule-of-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-debt-instruments-details" name="statement-statement-note-7-debt-schedule-of-debt-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-line-of-credit-facilities-details" name="statement-statement-note-7-debt-schedule-of-line-of-credit-facilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-7-debt-tables" name="statement-statement-note-7-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-9-accumulated-other-comprehensive-loss-changed-in-accumulated-other-comprehensive-loss-details" name="statement-statement-note-9-accumulated-other-comprehensive-loss-changed-in-accumulated-other-comprehensive-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-note-9-accumulated-other-comprehensive-loss-tables" name="statement-statement-note-9-accumulated-other-comprehensive-loss-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-condensed-financial-information-of-registrant-tables" name="statement-statement-schedule-i-condensed-financial-information-of-registrant-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-balance-sheets-details" name="statement-statement-schedule-i-parent-company-condensed-balance-sheets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-balance-sheets-details-parentheticals" name="statement-statement-schedule-i-parent-company-condensed-balance-sheets-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-cash-flows-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-cash-flows-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-comprehensive-income-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-comprehensive-income-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-income-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-income-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-schedule-i-schedule-of-debt-instruments-details" name="statement-statement-schedule-i-schedule-of-debt-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
<xsd:element abstract="true" id="opk_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>


20 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 1/09/24  Opko Health, Inc.                 8-K:1,2,3,9 1/04/24   14:1.1M                                   RDG Filings/FA
 8/03/23  Opko Health, Inc.                 10-Q        6/30/23   85:12M                                    RDG Filings/FA
 5/03/23  Opko Health, Inc.                 10-Q        3/31/23   86:11M
 2/27/23  Opko Health, Inc.                 10-K       12/31/22  121:20M
 7/15/22  Opko Health, Inc.                 8-K:1,5,9   7/14/22   12:504K
 5/13/22  Opko Health, Inc.                 8-K:1,3,5,9 5/09/22   14:1.3M
 5/04/22  Opko Health, Inc.                 8-K:1,8,9   4/29/22    2:145K
 1/18/22  Opko Health, Inc.                 8-K:1,9     1/14/22   12:1.6M
 9/03/21  Opko Health, Inc.                 8-K:1,9     8/30/21    2:1.3M
 7/29/21  Opko Health, Inc.                 10-Q        6/30/21   89:13M
 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
 7/31/20  Opko Health, Inc.                 10-Q        6/30/20   83:13M
 6/21/19  Opko Health, Inc.                 8-K:5,7,9   6/20/19    2:88K
 2/07/19  Opko Health, Inc.                 8-K:1,2,3,9 2/04/19    7:1.1M                                   Donnelley … Solutions/FA
 8/08/16  Opko Health, Inc.                 10-Q        6/30/16   80:10M
11/12/13  Opko Health, Inc.                 10-Q        9/30/13   76:14M
 2/05/13  Opko Health, Inc.                 8-K:1,2,3,8 1/30/13    3:751K                                   Donnelley … Solutions/FA
 7/05/11  Opko Health, Inc.                 10-Q/A      3/31/11    4:164K                                   Donnelley … Solutions/FA
 9/24/09  Opko Health, Inc.                 8-K:1,3,5,8 9/18/09    6:2.7M                                   Donnelley … Solutions/FA
 8/08/08  Opko Health, Inc.                 10-Q        6/30/08    8:1M                                     Toppan Merrill/FA
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Filing Submission 0001437749-24-006285   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

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