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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995495 - Disclosure - Note 5 - Acquisitions and Investments - Purchase Price Allocation (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995507 - Disclosure - Note 9 - Accumulated Other Comprehensive Loss - Changed in Accumulated Other Comprehensive Loss (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995530 - Disclosure - Note 18 - Segments (Details Textual) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995531 - Disclosure - Note 18 - Segments - Operations by Segment (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995532 - Disclosure - Note 18 - Segments - Assets by Segment (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995533 - Disclosure - Note 18 - Segments - Long-lived Assets by Segment (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995534 - Disclosure - Note 19 - Fair Value Measurements (Details Textual) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995535 - Disclosure - Note 19 - Fair Value Measurements - Financial Assets and Liabilities Measured on a Recurring Basis (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995536 - Disclosure - Note 19 - Fair Value Measurements - Carrying Value and Estimated Fair Value of Notes (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995537 - Disclosure - Note 19 - Fair Value Measurements - Reconciliation of Level 3 Liabilities (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995538 - Disclosure - Note 20 - Derivative Contracts - Summary of Fair Values and Presentation of Derivatives Financial Instruments (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995540 - Disclosure - Note 21 - Selected Quarterly Financial Data (Unaudited) - Summary of Selected Quarterly Financial Data (Details) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995542 - Disclosure - Schedule I - Condensed Financial Information of Registrant (Details Textual) </link:definition> |
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| <link:definition xmlns="http://www.xbrl.org/2003/linkbase"> 995543 - Disclosure - Schedule I - Parent Company Condensed Balance Sheets (Details) </link:definition> |
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| <xsd:element id="opk_CollaborativeAgreementOptionSalesMilestonePayments" name="CollaborativeAgreementOptionSalesMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_CollaborativeAgreementsEachMilestonePayment" name="CollaborativeAgreementsEachMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_CollaborativeArrangementDevelopmentCosts" name="CollaborativeArrangementDevelopmentCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementDevelopmentMilestonePayment" name="CollaborativeArrangementDevelopmentMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_CollaborativeArrangementDevelopmentMilestonePaymentShares" name="CollaborativeArrangementDevelopmentMilestonePaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementMaximumRegulatoryMilestonePayments" name="CollaborativeArrangementMaximumRegulatoryMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_CollaborativeArrangementPeriodFollowingFirstCommercialSale" name="CollaborativeArrangementPeriodFollowingFirstCommercialSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CollaborativeArrangementSalesMilestonePayment" name="CollaborativeArrangementSalesMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_CollaborativeArrangementUpfrontPaymentShares" name="CollaborativeArrangementUpfrontPaymentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CommonStockOptionsAndWarrantsNetExercised" name="CommonStockOptionsAndWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CommonStockOptionsWarrantsMember" name="CommonStockOptionsWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CommonStockVotingRightsVotes" name="CommonStockVotingRightsVotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_CommonwealthMember" name="CommonwealthMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ConsorcioBankMember" name="ConsorcioBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ConversionOfThe2025NotesIntoCommonStockMember" name="ConversionOfThe2025NotesIntoCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ConvertibleNotesMember" name="ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ConvertiblePreferredStockSharesDesignatedMaximum" name="ConvertiblePreferredStockSharesDesignatedMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ConvertibleSeniorNotesDue2025Member" name="ConvertibleSeniorNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CreditAgreementMember" name="CreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CurnaMember" name="CurnaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_CurrencyConcentrationRiskMember" name="CurrencyConcentrationRiskMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtConversionConvertedInstrumentSharesOutstanding" name="DebtConversionConvertedInstrumentSharesOutstanding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DebtInstrumentAggregatePrincipleAmountPurchasedOnClosingDate" name="DebtInstrumentAggregatePrincipleAmountPurchasedOnClosingDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentBasisSpreadOnVariableRateBenchmarkAdjustment" name="DebtInstrumentBasisSpreadOnVariableRateBenchmarkAdjustment" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentConvertibleConversionPremiumPerShare" name="DebtInstrumentConvertibleConversionPremiumPerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentConvertibleConversionPremiumPercent" name="DebtInstrumentConvertibleConversionPremiumPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentConvertibleDebtIncreaseDecreaseInMaximumSharesIssuable" name="DebtInstrumentConvertibleDebtIncreaseDecreaseInMaximumSharesIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_DebtInstrumentConvertibleDebtMaximumSharesIssuable" name="DebtInstrumentConvertibleDebtMaximumSharesIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DebtInstrumentOutstandingConvertibleNotes" name="DebtInstrumentOutstandingConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DebtInstrumentUnpaidAccruedInterest" name="DebtInstrumentUnpaidAccruedInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DeferredTaxAssetsCapitalizedResearchAndDevelopment" name="DeferredTaxAssetsCapitalizedResearchAndDevelopment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DeferredTaxAssetsLeaseLiability" name="DeferredTaxAssetsLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance" name="DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_DeferredTaxAssetsOperatingLeaseAsset" name="DeferredTaxAssetsOperatingLeaseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_DevelopmentAndLicenseAgreementMember" name="DevelopmentAndLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DiagnosticsMember" name="DiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_DravetSyndromeProductsMember" name="DravetSyndromeProductsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationDeemedDividendPercent" name="EffectiveIncomeTaxRateReconciliationDeemedDividendPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationImputedInterestPercent" name="EffectiveIncomeTaxRateReconciliationImputedInterestPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent" name="EffectiveIncomeTaxRateReconciliationIncomeTaxRefundPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueUpsPercent" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueUpsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActTransitionTaxOnAccumulatedForeignEarnings" name="EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsActTransitionTaxOnAccumulatedForeignEarnings" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationTransferPricingAdjustmentsPercent" name="EffectiveIncomeTaxRateReconciliationTransferPricingAdjustmentsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" name="EffectiveIncomeTaxRateReconciliationUnrecognizedTaxBenefitsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EirgenMember" name="EirgenMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EloxxPharmaceuticalsIncMember" name="EloxxPharmaceuticalsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_EquityIncentivePlan2007Member" name="EquityIncentivePlan2007Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_EquityInvestmentsCarryingValueOfEquityIntruments" name="EquityInvestmentsCarryingValueOfEquityIntruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquityMethodInvestmentExcludingVariableInterestEntity" name="EquityMethodInvestmentExcludingVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquityMethodInvestmentVariableInterestEntity" name="EquityMethodInvestmentVariableInterestEntity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquityMethodInvestmentVariableInterestEntityUnderlyingEquityInNetAssets" name="EquityMethodInvestmentVariableInterestEntityUnderlyingEquityInNetAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_EquitySecurityFvniOwnershipPercent" name="EquitySecurityFvniOwnershipPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_EstadoBankMember" name="EstadoBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyImpact" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FinetechMember" name="FinetechMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FirstMarketingApprovalOfRayaldeeInEuropeMember" name="FirstMarketingApprovalOfRayaldeeInEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_FullyVestedEquityAwardsMember" name="FullyVestedEquityAwardsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_GainLossOnConversionOfDebt" name="GainLossOnConversionOfDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GeneDxHoldingsCorpMember" name="GeneDxHoldingsCorpMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GeneDxHoldingsMember" name="GeneDxHoldingsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GeneDxLLCMember" name="GeneDxLLCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GeneDxMember" name="GeneDxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GermanyPriceApprovalByLocalSickFundAssociationMember" name="GermanyPriceApprovalByLocalSickFundAssociationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_GoodwillAcquiredDisposedOfDuringPeriod" name="GoodwillAcquiredDisposedOfDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GovernmentContractBardaMember" name="GovernmentContractBardaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GovernmentPayersMember" name="GovernmentPayersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_GovernmentalMember" name="GovernmentalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_HealthcareInsurersMember" name="HealthcareInsurersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_HealthsnapIncMember" name="HealthsnapIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_InCellDxMember" name="InCellDxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncomeLossFormSubsidiaries" name="IncomeLossFormSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncomeLossFromContinuingOperationsBeforeInvestmentsInInvesteesExtraordinaryItemsNetOfTax" name="IncomeLossFromContinuingOperationsBeforeInvestmentsInInvesteesExtraordinaryItemsNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments" name="IncomeLossFromContinuingOperationsBeforeTaxIncludingEquityMethodInvestments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncomeLossFromContinuingOperationsNetOfTaxBeforeEquityMethodInvestmentsAndNoncontrollingInterestTotal" name="IncomeLossFromContinuingOperationsNetOfTaxBeforeEquityMethodInvestmentsAndNoncontrollingInterestTotal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncreaseDecreaseInEquitySecuritiesFvniAndDerivativeInstruments" name="IncreaseDecreaseInEquitySecuritiesFvniAndDerivativeInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_IncreaseDecreaseInForeignCurrencyMeasurement" name="IncreaseDecreaseInForeignCurrencyMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_IndividualPatientsMember" name="IndividualPatientsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_IntegratedDNATechnologiesIncMember" name="IntegratedDNATechnologiesIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_InterestExpenseNonoperating" name="InterestExpenseNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_InterestIncomeNonoperating" name="InterestIncomeNonoperating" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_InternacionalBankMember" name="InternacionalBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_InvestmentNetMember" name="InvestmentNetMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_InvestmentOwnedSharesPurchased" name="InvestmentOwnedSharesPurchased" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ItauBankMember" name="ItauBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_JPMorganChaseMember" name="JPMorganChaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LeaderMedJointVentureMember" name="LeaderMedJointVentureMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LeaderMedMember" name="LeaderMedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LeicaMicrosystemsIncMember" name="LeicaMicrosystemsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LesseeLeaseLiabilityMaturityTableTextBlock" name="LesseeLeaseLiabilityMaturityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LesseeLeasesTextBlock" name="LesseeLeasesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LicenseAgreementMember" name="LicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_LineOfCreditAndNotesAndLoansPayableCurrentMember" name="LineOfCreditAndNotesAndLoansPayableCurrentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_LitigationSettlementInterestRate" name="LitigationSettlementInterestRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_LondonInterbankOfferedRateMember" name="LondonInterbankOfferedRateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MachineryMedicalAndOtherEquipmentMember" name="MachineryMedicalAndOtherEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MedicareAndMedicaidMember" name="MedicareAndMedicaidMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MerckAgreementMember" name="MerckAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MerckSharpDohmeLLCMember" name="MerckSharpDohmeLLCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_MilestonePaymentsMember" name="MilestonePaymentsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_MinorityInterestSharesIssued" name="MinorityInterestSharesIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ModexTherapeuticsIncMember" name="ModexTherapeuticsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NeovascMember" name="NeovascMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NewCreditAgreementMember" name="NewCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NicoyaMacauLimitedMember" name="NicoyaMacauLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NimsMember" name="NimsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_NoncashRevenueFromTransferOfIntellectualProperty" name="NoncashRevenueFromTransferOfIntellectualProperty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NondravetSyndromeProductsMember" name="NondravetSyndromeProductsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NoninvasiveMonitoringSystemsIncMember" name="NoninvasiveMonitoringSystemsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NotesAndOtherDebtMember" name="NotesAndOtherDebtMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NotesPayableAndOtherLongTermLiabilitiesMember" name="NotesPayableAndOtherLongTermLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_NumberOfMajorCustomers" name="NumberOfMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OPKOHealthSavingsAndRetirementPlanMember" name="OPKOHealthSavingsAndRetirementPlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OfficeSpaceMember" name="OfficeSpaceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_OperatingLeaseMonthlyRentExpense" name="OperatingLeaseMonthlyRentExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearFive" name="OperatingLeasesMonthlyPaymentsYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element id="opk_OperatingLeasesMonthlyPaymentsYearOne" name="OperatingLeasesMonthlyPaymentsYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_OpkoBiologicsMember" name="OpkoBiologicsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OpkoChileMember" name="OpkoChileMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OpkoDiagnosticsMember" name="OpkoDiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OpkoHealthEuropeMember" name="OpkoHealthEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OpkoMexicoMember" name="OpkoMexicoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_OptionsExercisedAndRestrictedStockUnitsSettledShares" name="OptionsExercisedAndRestrictedStockUnitsSettledShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_OwnershipPercentage" name="OwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/> |
| <xsd:element id="opk_PaymentsForLeases" name="PaymentsForLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PfizerAgreementMember" name="PfizerAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PfizerIncMember" name="PfizerIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PharmaceuticalMember" name="PharmaceuticalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PharmsynthezMember" name="PharmsynthezMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ProceedsFromConvertibleDebtConversionFee" name="ProceedsFromConvertibleDebtConversionFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ProceedsFromRepurchaseOfStockOptionsAndWarrantsExercised" name="ProceedsFromRepurchaseOfStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ProjectRegistrationMember" name="ProjectRegistrationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_PropertyPlantAndEquipmentNetMember" name="PropertyPlantAndEquipmentNetMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ProvisionForSalesAllowanceAsPercentOfGrossSales" name="ProvisionForSalesAllowanceAsPercentOfGrossSales" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_QuarterlyAvailabilityIs50OrMoreMember" name="QuarterlyAvailabilityIs50OrMoreMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_QuarterlyAvailabilityIsLessThan50Member" name="QuarterlyAvailabilityIsLessThan50Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_RayaldeeMember" name="RayaldeeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ReclassificationFromInProcessResearchAndDevelopmentMember" name="ReclassificationFromInProcessResearchAndDevelopmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ReimbursementOfTravelExpensesMember" name="ReimbursementOfTravelExpensesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_RestrictedNetAssets" name="RestrictedNetAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/> |
| <xsd:element abstract="true" id="opk_RuenhuiBiopharmaceuticalsIncMember" name="RuenhuiBiopharmaceuticalsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SalesReturnsMember" name="SalesReturnsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SantanderBank2Member" name="SantanderBank2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SantanderBankMember" name="SantanderBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" name="ScheduleOfProductSalesAllowancesAndAccrualsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ScheduleOfSupplementalCashFlowInformationOfLeasesTableTextBlock" name="ScheduleOfSupplementalCashFlowInformationOfLeasesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ScotiabankMember" name="ScotiabankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SecuredOvernightFinancingRate12MonthsMember" name="SecuredOvernightFinancingRate12MonthsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SecurityBankMember" name="SecurityBankMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_SeriesA2PreferredStockMember" name="SeriesA2PreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ServicesRenderedMember" name="ServicesRenderedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_SharesIncludedInBusinessDivestureCashFlowImpact" name="SharesIncludedInBusinessDivestureCashFlowImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_ShippingAndHandlingCostsPolicyTextBlock" name="ShippingAndHandlingCostsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockIssuedAsPartOfAnAcquisitionCashFlowImpact" name="StockIssuedAsPartOfAnAcquisitionCashFlowImpact" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockIssuedDuringPeriodSharesOptionsExercisedAndRestrictedStockUnitsSettled" name="StockIssuedDuringPeriodSharesOptionsExercisedAndRestrictedStockUnitsSettled" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/> |
| <xsd:element id="opk_StockholdersEquityReverseStockSplitConversionPerShare" name="StockholdersEquityReverseStockSplitConversionPerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/> |
| <xsd:element id="opk_TaxCreditCarryforwardExpirationPeriod" name="TaxCreditCarryforwardExpirationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TaxYear2014ThroughTaxYear2020Member" name="TaxYear2014ThroughTaxYear2020Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TexasMedicaidOfficeMember" name="TexasMedicaidOfficeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_Th2029ConvertibleNotesMember" name="Th2029ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_The2023ConvertibleNotesMember" name="The2023ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_The2025NotesMember" name="The2025NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_The2029NotesMember" name="The2029NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_The2033SeniorNotesMember" name="The2033SeniorNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TransferOfIntellectualPropertyAndOtherMember" name="TransferOfIntellectualPropertyAndOtherMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TransitionServicesAgreementMember" name="TransitionServicesAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_TransitionTherapeuticsMember" name="TransitionTherapeuticsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_VbiVaccinesIncMember" name="VbiVaccinesIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ViforFreseniusMedicalCareRenalPharmaLtdMember" name="ViforFreseniusMedicalCareRenalPharmaLtdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_XeneticMember" name="XeneticMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_ZebraMember" name="ZebraMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-schedule-of-valuation-assumptions-details" name="statement-statement-note-10-equitybased-compensation-schedule-of-valuation-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-summary-of-restricted-stock-units-details" name="statement-statement-note-10-equitybased-compensation-summary-of-restricted-stock-units-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-summary-of-stock-option-activity-details" name="statement-statement-note-10-equitybased-compensation-summary-of-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-10-equitybased-compensation-tables" name="statement-statement-note-10-equitybased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-components-of-income-tax-expense-details" name="statement-statement-note-11-income-taxes-components-of-income-tax-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-income-loss-before-income-taxes-details" name="statement-statement-note-11-income-taxes-income-loss-before-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-reconciliation-of-effective-income-tax-rate-details" name="statement-statement-note-11-income-taxes-reconciliation-of-effective-income-tax-rate-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" name="statement-statement-note-11-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-schedule-of-unrecognized-tax-benefits-details" name="statement-statement-note-11-income-taxes-schedule-of-unrecognized-tax-benefits-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-11-income-taxes-tables" name="statement-statement-note-11-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-analysis-of-product-sales-allowances-and-accruals-details" name="statement-statement-note-15-revenue-recognition-analysis-of-product-sales-allowances-and-accruals-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-changes-in-contractual-liabilities-details" name="statement-statement-note-15-revenue-recognition-changes-in-contractual-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-composition-of-revenue-from-services-details" name="statement-statement-note-15-revenue-recognition-composition-of-revenue-from-services-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-15-revenue-recognition-tables" name="statement-statement-note-15-revenue-recognition-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-17-leases-lease-balances-details" name="statement-statement-note-17-leases-lease-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-17-leases-supplemental-cash-flow-information-details" name="statement-statement-note-17-leases-supplemental-cash-flow-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-17-leases-tables" name="statement-statement-note-17-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-17-leases-undiscounted-future-minimum-lease-payments-details" name="statement-statement-note-17-leases-undiscounted-future-minimum-lease-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-18-segments-assets-by-segment-details" name="statement-statement-note-18-segments-assets-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-18-segments-longlived-assets-by-segment-details" name="statement-statement-note-18-segments-longlived-assets-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-18-segments-operations-by-segment-details" name="statement-statement-note-18-segments-operations-by-segment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-18-segments-tables" name="statement-statement-note-18-segments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-carrying-value-and-estimated-fair-value-of-notes-details" name="statement-statement-note-19-fair-value-measurements-carrying-value-and-estimated-fair-value-of-notes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-financial-assets-and-liabilities-measured-on-a-recurring-basis-details" name="statement-statement-note-19-fair-value-measurements-financial-assets-and-liabilities-measured-on-a-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-reconciliation-of-level-3-liabilities-details" name="statement-statement-note-19-fair-value-measurements-reconciliation-of-level-3-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-19-fair-value-measurements-tables" name="statement-statement-note-19-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-summary-of-fair-values-and-presentation-of-derivatives-financial-instruments-details" name="statement-statement-note-20-derivative-contracts-summary-of-fair-values-and-presentation-of-derivatives-financial-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-summary-of-gains-and-losses-recorded-details" name="statement-statement-note-20-derivative-contracts-summary-of-gains-and-losses-recorded-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-20-derivative-contracts-tables" name="statement-statement-note-20-derivative-contracts-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-21-selected-quarterly-financial-data-unaudited-summary-of-selected-quarterly-financial-data-details" name="statement-statement-note-21-selected-quarterly-financial-data-unaudited-summary-of-selected-quarterly-financial-data-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-21-selected-quarterly-financial-data-unaudited-tables" name="statement-statement-note-21-selected-quarterly-financial-data-unaudited-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-gains-and-losses-on-equity-securities-details" name="statement-statement-note-5-acquisitions-and-investments-gains-and-losses-on-equity-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-purchase-price-allocation-details" name="statement-statement-note-5-acquisitions-and-investments-purchase-price-allocation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-schedule-of-investments-details" name="statement-statement-note-5-acquisitions-and-investments-schedule-of-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-5-acquisitions-and-investments-tables" name="statement-statement-note-5-acquisitions-and-investments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-financial-statement-information-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-financial-statement-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-goodwill-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-schedule-of-goodwill-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-summary-of-allowance-for-doubtful-accounts-inventory-reserve-and-tax-valuation-allowance-details" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-summary-of-allowance-for-doubtful-accounts-inventory-reserve-and-tax-valuation-allowance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-6-composition-of-certain-financial-statement-captions-tables" name="statement-statement-note-6-composition-of-certain-financial-statement-captions-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-debt-details" name="statement-statement-note-7-debt-schedule-of-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-debt-instruments-details" name="statement-statement-note-7-debt-schedule-of-debt-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-7-debt-schedule-of-line-of-credit-facilities-details" name="statement-statement-note-7-debt-schedule-of-line-of-credit-facilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-7-debt-tables" name="statement-statement-note-7-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-9-accumulated-other-comprehensive-loss-changed-in-accumulated-other-comprehensive-loss-details" name="statement-statement-note-9-accumulated-other-comprehensive-loss-changed-in-accumulated-other-comprehensive-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-note-9-accumulated-other-comprehensive-loss-tables" name="statement-statement-note-9-accumulated-other-comprehensive-loss-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-condensed-financial-information-of-registrant-tables" name="statement-statement-schedule-i-condensed-financial-information-of-registrant-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-balance-sheets-details" name="statement-statement-schedule-i-parent-company-condensed-balance-sheets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-balance-sheets-details-parentheticals" name="statement-statement-schedule-i-parent-company-condensed-balance-sheets-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-cash-flows-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-cash-flows-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-comprehensive-income-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-comprehensive-income-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-parent-company-condensed-statements-of-income-details" name="statement-statement-schedule-i-parent-company-condensed-statements-of-income-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-schedule-i-schedule-of-debt-instruments-details" name="statement-statement-schedule-i-schedule-of-debt-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| <xsd:element abstract="true" id="opk_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/> |
| </xsd:schema> |