SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Pacira BioSciences, Inc. – ‘10-K’ for 12/31/14 – ‘EX-101.PRE’

On:  Tuesday, 2/24/15, at 3:43pm ET   ·   For:  12/31/14   ·   Accession #:  1396814-15-3   ·   File #:  1-35060

Previous ‘10-K’:  ‘10-K’ on 2/25/14 for 12/31/13   ·   Next:  ‘10-K’ on 2/25/16 for 12/31/15   ·   Latest:  ‘10-K’ on 2/29/24 for 12/31/23

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 2/24/15  Pacira BioSciences, Inc.          10-K       12/31/14   87:11M

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.09M 
 2: EX-21.1     Subsidiaries List                                   HTML     21K 
 3: EX-23.1     Consent of Experts or Counsel                       HTML     24K 
 4: EX-31.1     Certification -- §302 - SOA'02                      HTML     29K 
 5: EX-31.2     Certification -- §302 - SOA'02                      HTML     29K 
 6: EX-32.1     Certification -- §906 - SOA'02                      HTML     23K 
 7: EX-32.2     Certification -- §906 - SOA'02                      HTML     23K 
59: R1          Document and Entity Information                     HTML     52K 
46: R2          Consolidated Balance Sheets                         HTML    136K 
57: R3          Consolidated Balance Sheets (Parenthetical)         HTML     50K 
61: R4          Consolidated Statements of Operations               HTML     98K 
80: R5          Consolidated Statements of Comprehensive Loss       HTML     43K 
48: R6          Consolidated Statements of Stockholders' Equity     HTML    142K 
                (Deficit)                                                        
56: R7          Consolidated Statements of Cash Flows               HTML    156K 
42: R8          Description of Business                             HTML     31K 
31: R9          Summary of Significant Accounting Policies          HTML     88K 
81: R10         Recent Accounting Pronouncements                    HTML     28K 
63: R11         Inventories                                         HTML     33K 
62: R12         Fixed Assets                                        HTML     42K 
68: R13         Goodwill and Intangible Assets                      HTML     75K 
69: R14         Accrued Expenses                                    HTML     37K 
66: R15         Debt                                                HTML     79K 
70: R16         Financial Instruments                               HTML     93K 
58: R17         Stockholders' Equity                                HTML     44K 
60: R18         Stock Plans                                         HTML    137K 
65: R19         Net Income (Loss) Per Share                         HTML     56K 
87: R20         Income Taxes                                        HTML     78K 
76: R21         Other Employee Benefits                             HTML     26K 
52: R22         Commercial Partners and Other Agreements            HTML     44K 
64: R23         Related Party Transactions                          HTML     34K 
54: R24         Commitments and Contingencies                       HTML     46K 
23: R25         Selected Quarterly Financial Data (Unaudited)       HTML     71K 
77: R26         Subsequent Events (Notes)                           HTML     25K 
84: R27         Summary of Significant Accounting Policies          HTML    160K 
                (Policies)                                                       
37: R28         Summary of Significant Accounting Policies          HTML     44K 
                (Tables)                                                         
36: R29         Inventories (Tables)                                HTML     32K 
40: R30         Fixed Assets (Tables)                               HTML     37K 
41: R31         Goodwill and Intangible Assets (Tables)             HTML     73K 
43: R32         Accrued Expenses (Tables)                           HTML     36K 
21: R33         Debt (Tables)                                       HTML     47K 
74: R34         Financial Instruments (Tables)                      HTML     85K 
50: R35         Stockholders' Equity (Tables)                       HTML     32K 
53: R36         Stock Plans (Tables)                                HTML    133K 
26: R37         Net Income (Loss) Per Share (Tables)                HTML     54K 
86: R38         Income Taxes (Tables)                               HTML     64K 
14: R39         Commitments and Contingencies (Tables)              HTML     33K 
44: R40         Selected Quarterly Financial Data (Unaudited)       HTML     69K 
                (Tables)                                                         
79: R41         Summary of Significant Accounting Policies          HTML     41K 
                (Details)                                                        
25: R42         Summary of Significant Accounting Policies          HTML     48K 
                (Details 2)                                                      
35: R43         Summary of Significant Accounting Policies          HTML     40K 
                (Details 3)                                                      
39: R44         Inventories (Details)                               HTML     37K 
47: R45         Fixed Assets (Details)                              HTML     55K 
20: R46         Goodwill and Intangible Assets (Details)            HTML     70K 
30: R47         Goodwill and Intangible Assets (Details 2)          HTML     67K 
16: R48         Accrued Expenses (Details)                          HTML     44K 
78: R49         Debt (Details)                                      HTML     37K 
24: R50         Debt (Details 2)                                    HTML    202K 
75: R51         Financial Instruments (Details)                     HTML    139K 
27: R52         Financial Instruments (Details 2)                   HTML     94K 
45: R53         Financial Instruments (Details 3)                   HTML     36K 
15: R54         Stockholders' Equity (Details)                      HTML     54K 
19: R55         Stockholders' Equity (Details 2)                    HTML     40K 
38: R56         Stock Plans (Details)                               HTML     65K 
22: R57         Stock Plans (Details 2)                             HTML     49K 
82: R58         Stock Plans (Details 3)                             HTML    151K 
49: R59         Net Income (Loss) Per Share (Details)               HTML     49K 
67: R60         Net Income (Loss) Per Share (Details 2)             HTML     45K 
29: R61         Income Taxes (Details)                              HTML    120K 
32: R62         Income Taxes (Details 2)                            HTML     54K 
73: R63         Other Employee Benefits (Details)                   HTML     25K 
71: R64         Commercial Partners and Other Agreements (Details)  HTML     51K 
51: R65         Related Party Transactions (Details)                HTML     63K 
72: R66         Commitments and Contingencies (Details)             HTML     58K 
28: R67         Commitments and Contingencies (Details 2)           HTML     28K 
55: R68         Commitments and Contingencies (Details 3)           HTML     37K 
83: R69         Selected Quarterly Financial Data (Unaudited)       HTML     58K 
                (Details)                                                        
18: R70         Subsequent Events (Details)                         HTML     26K 
85: XML         IDEA XML File -- Filing Summary                      XML    135K 
17: EXCEL       IDEA Workbook of Financial Reports                  XLSX    215K 
33: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.50M 
 8: EX-101.INS  XBRL Instance -- pcrx-20141231                       XML   2.21M 
10: EX-101.CAL  XBRL Calculations -- pcrx-20141231_cal               XML    227K 
11: EX-101.DEF  XBRL Definitions -- pcrx-20141231_def                XML    659K 
12: EX-101.LAB  XBRL Labels -- pcrx-20141231_lab                     XML   2.02M 
13: EX-101.PRE  XBRL Presentations -- pcrx-20141231_pre              XML   1.06M 
 9: EX-101.SCH  XBRL Schema -- pcrx-20141231                         XSD    216K 
34: ZIP         XBRL Zipped Folder -- 0001396814-15-000003-xbrl      Zip    266K

‘EX-101.PRE’   —   XBRL Presentations — pcrx-20141231_pre

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva, formerly WebFilings -->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<roleRef roleURI="http://www.pacira.com/role/AccruedExpenses" xlink:href="pcrx-20141231.xsd#AccruedExpenses" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/AccruedExpensesDetails" xlink:href="pcrx-20141231.xsd#AccruedExpensesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/AccruedExpensesTables" xlink:href="pcrx-20141231.xsd#AccruedExpensesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommercialPartnersAndOtherAgreements" xlink:href="pcrx-20141231.xsd#CommercialPartnersAndOtherAgreements" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommercialPartnersAndOtherAgreementsDetails" xlink:href="pcrx-20141231.xsd#CommercialPartnersAndOtherAgreementsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommitmentsAndContingencies" xlink:href="pcrx-20141231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommitmentsAndContingenciesDetails" xlink:href="pcrx-20141231.xsd#CommitmentsAndContingenciesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommitmentsAndContingenciesDetails2" xlink:href="pcrx-20141231.xsd#CommitmentsAndContingenciesDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommitmentsAndContingenciesDetails3" xlink:href="pcrx-20141231.xsd#CommitmentsAndContingenciesDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/CommitmentsAndContingenciesTables" xlink:href="pcrx-20141231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedBalanceSheets" xlink:href="pcrx-20141231.xsd#ConsolidatedBalanceSheets" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="pcrx-20141231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="pcrx-20141231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:href="pcrx-20141231.xsd#ConsolidatedStatementsOfComprehensiveLoss" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedStatementsOfOperations" xlink:href="pcrx-20141231.xsd#ConsolidatedStatementsOfOperations" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:href="pcrx-20141231.xsd#ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/Debt" xlink:href="pcrx-20141231.xsd#Debt" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/DebtDetails" xlink:href="pcrx-20141231.xsd#DebtDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/DebtDetails2" xlink:href="pcrx-20141231.xsd#DebtDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/DebtTables" xlink:href="pcrx-20141231.xsd#DebtTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/DescriptionOfBusiness" xlink:href="pcrx-20141231.xsd#DescriptionOfBusiness" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/DocumentAndEntityInformation" xlink:href="pcrx-20141231.xsd#DocumentAndEntityInformation" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FinancialInstruments" xlink:href="pcrx-20141231.xsd#FinancialInstruments" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FinancialInstrumentsDetails" xlink:href="pcrx-20141231.xsd#FinancialInstrumentsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FinancialInstrumentsDetails2" xlink:href="pcrx-20141231.xsd#FinancialInstrumentsDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FinancialInstrumentsDetails3" xlink:href="pcrx-20141231.xsd#FinancialInstrumentsDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FinancialInstrumentsTables" xlink:href="pcrx-20141231.xsd#FinancialInstrumentsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FixedAssets" xlink:href="pcrx-20141231.xsd#FixedAssets" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FixedAssetsDetails" xlink:href="pcrx-20141231.xsd#FixedAssetsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/FixedAssetsTables" xlink:href="pcrx-20141231.xsd#FixedAssetsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/GoodwillAndIntangibleAssets" xlink:href="pcrx-20141231.xsd#GoodwillAndIntangibleAssets" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/GoodwillAndIntangibleAssetsDetails" xlink:href="pcrx-20141231.xsd#GoodwillAndIntangibleAssetsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/GoodwillAndIntangibleAssetsDetails2" xlink:href="pcrx-20141231.xsd#GoodwillAndIntangibleAssetsDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/GoodwillAndIntangibleAssetsTables" xlink:href="pcrx-20141231.xsd#GoodwillAndIntangibleAssetsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/IncomeTaxes" xlink:href="pcrx-20141231.xsd#IncomeTaxes" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/IncomeTaxesDetails" xlink:href="pcrx-20141231.xsd#IncomeTaxesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/IncomeTaxesDetails2" xlink:href="pcrx-20141231.xsd#IncomeTaxesDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/IncomeTaxesTables" xlink:href="pcrx-20141231.xsd#IncomeTaxesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/Inventories" xlink:href="pcrx-20141231.xsd#Inventories" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/InventoriesDetails" xlink:href="pcrx-20141231.xsd#InventoriesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/InventoriesTables" xlink:href="pcrx-20141231.xsd#InventoriesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/NetIncomeLossPerShare" xlink:href="pcrx-20141231.xsd#NetIncomeLossPerShare" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/NetIncomeLossPerShareDetails" xlink:href="pcrx-20141231.xsd#NetIncomeLossPerShareDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/NetIncomeLossPerShareDetails2" xlink:href="pcrx-20141231.xsd#NetIncomeLossPerShareDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/NetIncomeLossPerShareTables" xlink:href="pcrx-20141231.xsd#NetIncomeLossPerShareTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/OtherEmployeeBenefits" xlink:href="pcrx-20141231.xsd#OtherEmployeeBenefits" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/OtherEmployeeBenefitsDetails" xlink:href="pcrx-20141231.xsd#OtherEmployeeBenefitsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/RecentAccountingPronouncements" xlink:href="pcrx-20141231.xsd#RecentAccountingPronouncements" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/RelatedPartyTransactions" xlink:href="pcrx-20141231.xsd#RelatedPartyTransactions" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/RelatedPartyTransactionsDetails" xlink:href="pcrx-20141231.xsd#RelatedPartyTransactionsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:href="pcrx-20141231.xsd#SelectedQuarterlyFinancialDataUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnauditedDetails" xlink:href="pcrx-20141231.xsd#SelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:href="pcrx-20141231.xsd#SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockPlans" xlink:href="pcrx-20141231.xsd#StockPlans" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockPlansDetails" xlink:href="pcrx-20141231.xsd#StockPlansDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockPlansDetails2" xlink:href="pcrx-20141231.xsd#StockPlansDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockPlansDetails3" xlink:href="pcrx-20141231.xsd#StockPlansDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockPlansTables" xlink:href="pcrx-20141231.xsd#StockPlansTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockholdersEquity" xlink:href="pcrx-20141231.xsd#StockholdersEquity" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockholdersEquityDetails" xlink:href="pcrx-20141231.xsd#StockholdersEquityDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockholdersEquityDetails2" xlink:href="pcrx-20141231.xsd#StockholdersEquityDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/StockholdersEquityTables" xlink:href="pcrx-20141231.xsd#StockholdersEquityTables" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SubsequentEventsDetails" xlink:href="pcrx-20141231.xsd#SubsequentEventsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SubsequentEventsNotes" xlink:href="pcrx-20141231.xsd#SubsequentEventsNotes" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails2" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPoliciesDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails3" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPoliciesDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<roleRef roleURI="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="pcrx-20141231.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple"/>
<roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple"/>
<presentationLink xlink:role="http://www.pacira.com/role/AccruedExpenses" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_745A40C92097D10F34F06F31F4C5339E" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_82E1C18794B77D5183976F31F4C548F8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_745A40C92097D10F34F06F31F4C5339E" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_82E1C18794B77D5183976F31F4C548F8" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/AccruedExpensesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_24A9377B1494A581EAC0A36761AE15F6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_24A9377B1494A581EAC0A36761AE15F6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AccruedOperatingExpensesCurrent" xlink:label="loc_pcrx_AccruedOperatingExpensesCurrent_DFD61AAE65DCA43954EAA36761AF63BF" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_pcrx_AccruedOperatingExpensesCurrent_DFD61AAE65DCA43954EAA36761AF63BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_1564A9B6262DB2FF4668A36761AF5754" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_1564A9B6262DB2FF4668A36761AF5754" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AccruedEndOfTermFeeCurrent" xlink:label="loc_pcrx_AccruedEndOfTermFeeCurrent_6381C867F091080A19D4A36761AF2BBF" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_pcrx_AccruedEndOfTermFeeCurrent_6381C867F091080A19D4A36761AF2BBF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ProductReturnsRebatesandOtherFees" xlink:label="loc_pcrx_ProductReturnsRebatesandOtherFees_8E36BB6F99B46F2EDE79A36761AFC440" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_pcrx_ProductReturnsRebatesandOtherFees_8E36BB6F99B46F2EDE79A36761AFC440" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedIncomeTaxes" xlink:label="loc_us-gaap_AccruedIncomeTaxes_90FF5767AA49C350AFCCA36761B0036B" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_us-gaap_AccruedIncomeTaxes_90FF5767AA49C350AFCCA36761B0036B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_3336A88B1F155406160AA36761B03948" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B54EDC26800C9FD0DD8CA36761AE8281" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_3336A88B1F155406160AA36761B03948" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/AccruedExpensesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_08036AFC776037AE49A36F31F70F67E1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_D6EA5C1B8EAF64AC44326F31F70FE506" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_08036AFC776037AE49A36F31F70F67E1" xlink:to="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_D6EA5C1B8EAF64AC44326F31F70FE506" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommercialPartnersAndOtherAgreements" xlink:type="extended">
<loc xlink:href="pcrx-20141231.xsd#pcrx_CommercialPartnersAndAgreementsAbstract" xlink:label="loc_pcrx_CommercialPartnersAndAgreementsAbstract_63D67BF3560799F0AAA56F31F4B12793" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CommercialPartnersAndAgreementsTextBlock" xlink:label="loc_pcrx_CommercialPartnersAndAgreementsTextBlock_77FDE9CBD2D3EEAE71F96F31F4B2AE94" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_CommercialPartnersAndAgreementsAbstract_63D67BF3560799F0AAA56F31F4B12793" xlink:to="loc_pcrx_CommercialPartnersAndAgreementsTextBlock_77FDE9CBD2D3EEAE71F96F31F4B2AE94" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommercialPartnersAndOtherAgreementsDetails" xlink:type="extended">
<loc xlink:href="pcrx-20141231.xsd#pcrx_CommercialPartnersAndAgreementsAbstract" xlink:label="loc_pcrx_CommercialPartnersAndAgreementsAbstract_97E63034D24E553866C26B0030A30C7F" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_CommercialPartnersAndAgreementsAbstract_97E63034D24E553866C26B0030A30C7F" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PartiesToContractualArrangementAxis" xlink:label="loc_us-gaap_PartiesToContractualArrangementAxis_8257A6B34E7C25407EDA6B0030A31C4E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_us-gaap_PartiesToContractualArrangementAxis_8257A6B34E7C25407EDA6B0030A31C4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PartiesToContractualArrangementMember" xlink:label="loc_us-gaap_PartiesToContractualArrangementMember_0240115069C4E7C7B2CE6B0030A38B08" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PartiesToContractualArrangementAxis_8257A6B34E7C25407EDA6B0030A31C4E" xlink:to="loc_us-gaap_PartiesToContractualArrangementMember_0240115069C4E7C7B2CE6B0030A38B08" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PatheonMember" xlink:label="loc_pcrx_PatheonMember_A4675735246455841DA96B0030A30768" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PartiesToContractualArrangementMember_0240115069C4E7C7B2CE6B0030A38B08" xlink:to="loc_pcrx_PatheonMember_A4675735246455841DA96B0030A30768" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MundipharmaLtdMember" xlink:label="loc_pcrx_MundipharmaLtdMember_3D6A781CCF69A8F798E66B0254FE330B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PartiesToContractualArrangementMember_0240115069C4E7C7B2CE6B0030A38B08" xlink:to="loc_pcrx_MundipharmaLtdMember_3D6A781CCF69A8F798E66B0254FE330B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherCommitmentsAxis" xlink:label="loc_us-gaap_OtherCommitmentsAxis_67406107E6CAF707D4FC6B0030A30949" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_us-gaap_OtherCommitmentsAxis_67406107E6CAF707D4FC6B0030A30949" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherCommitmentsDomain" xlink:label="loc_us-gaap_OtherCommitmentsDomain_A9CA896056AA451553DC6B0030A37A52" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsAxis_67406107E6CAF707D4FC6B0030A30949" xlink:to="loc_us-gaap_OtherCommitmentsDomain_A9CA896056AA451553DC6B0030A37A52" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_70F8726002FFF9F06E216B0030A324DC" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_us-gaap_TypeOfArrangementAxis_70F8726002FFF9F06E216B0030A324DC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4373F46ACBAD7921088D6B0030A312BF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_70F8726002FFF9F06E216B0030A324DC" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4373F46ACBAD7921088D6B0030A312BF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AratanaTherapeuticsIncMember" xlink:label="loc_pcrx_AratanaTherapeuticsIncMember_8E8EAE3FD62C332ED50E6B0030A364CC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4373F46ACBAD7921088D6B0030A312BF" xlink:to="loc_pcrx_AratanaTherapeuticsIncMember_8E8EAE3FD62C332ED50E6B0030A364CC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NovoNordiskASMember" xlink:label="loc_pcrx_NovoNordiskASMember_D029473E915BF0D0CB5A6B0030A3E40C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4373F46ACBAD7921088D6B0030A312BF" xlink:to="loc_pcrx_NovoNordiskASMember_D029473E915BF0D0CB5A6B0030A3E40C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_DCEAC70DBB776C8C218C6B0030A3DE81" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_us-gaap_RangeAxis_DCEAC70DBB776C8C218C6B0030A3DE81" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_D6F6E51F5340EE1A40076B0030A3FD6E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_DCEAC70DBB776C8C218C6B0030A3DE81" xlink:to="loc_us-gaap_RangeMember_D6F6E51F5340EE1A40076B0030A3FD6E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_C9F85901EB19FEE0E0806B0030A36687" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_D6F6E51F5340EE1A40076B0030A3FD6E" xlink:to="loc_us-gaap_MaximumMember_C9F85901EB19FEE0E0806B0030A36687" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AchievementOfMilestoneAxis" xlink:label="loc_pcrx_AchievementOfMilestoneAxis_21E173045A5CA709C2696B0030A3203A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_pcrx_AchievementOfMilestoneAxis_21E173045A5CA709C2696B0030A3203A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AchievementOfMilestoneDomain" xlink:label="loc_pcrx_AchievementOfMilestoneDomain_CCA310969846B11E359E6B0030A334DF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AchievementOfMilestoneAxis_21E173045A5CA709C2696B0030A3203A" xlink:to="loc_pcrx_AchievementOfMilestoneDomain_CCA310969846B11E359E6B0030A334DF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AchievementOfDevelopmentAndCommercialMilestonesMember" xlink:label="loc_pcrx_AchievementOfDevelopmentAndCommercialMilestonesMember_BE0AE2405FAD32DF17706B0030A356C5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AchievementOfMilestoneDomain_CCA310969846B11E359E6B0030A334DF" xlink:to="loc_pcrx_AchievementOfDevelopmentAndCommercialMilestonesMember_BE0AE2405FAD32DF17706B0030A356C5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5EDB5E3C2274DE0A51E86B0030A3F272" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ContractTerminationFee" xlink:label="loc_pcrx_ContractTerminationFee_BA30D83E21292BF1F53B6B0030A33B43" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_ContractTerminationFee_BA30D83E21292BF1F53B6B0030A33B43" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_InitialTermofManufacturingSupplyAgreement" xlink:label="loc_pcrx_InitialTermofManufacturingSupplyAgreement_88CBBE09CF77B0AD1B826B0047834897" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_InitialTermofManufacturingSupplyAgreement_88CBBE09CF77B0AD1B826B0047834897" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CollaborativeArrangementUpfrontPaymentReceived" xlink:label="loc_pcrx_CollaborativeArrangementUpfrontPaymentReceived_5C7B11DB260E35E6C68A6B0030A35602" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_CollaborativeArrangementUpfrontPaymentReceived_5C7B11DB260E35E6C68A6B0030A35602" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CollaborativeArrangementMilestonePaymentsToBeReceived" xlink:label="loc_pcrx_CollaborativeArrangementMilestonePaymentsToBeReceived_22052C15051A5738D84C6B0030A3CFF5" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_CollaborativeArrangementMilestonePaymentsToBeReceived_22052C15051A5738D84C6B0030A3CFF5" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CollaborativeArrangementMilestonePaymentsReceived" xlink:label="loc_pcrx_CollaborativeArrangementMilestonePaymentsReceived_D38C33A0ACB7F2F547E96B0030A30073" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_CollaborativeArrangementMilestonePaymentsReceived_D38C33A0ACB7F2F547E96B0030A30073" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TermExtensionof2003Agreements" xlink:label="loc_pcrx_TermExtensionof2003Agreements_09F6EAF2F313E891D8F56B0254EF057C" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_TermExtensionof2003Agreements_09F6EAF2F313E891D8F56B0254EF057C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EuropeanRightsExpansionNewDistributionPayment" xlink:label="loc_pcrx_EuropeanRightsExpansionNewDistributionPayment_6906E3528344899D4D506B03F0FA49C0" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_AF10E43F0E97026F3BA46B0030A33792" xlink:to="loc_pcrx_EuropeanRightsExpansionNewDistributionPayment_6906E3528344899D4D506B03F0FA49C0" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommitmentsAndContingencies" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_F06C8548270412AB37C56F31F4EAB661" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_0E600497A87500D4B88C6F31F4EA3AEB" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_F06C8548270412AB37C56F31F4EAB661" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_0E600497A87500D4B88C6F31F4EA3AEB" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommitmentsAndContingenciesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EAC6C132D26EFB4AD783A41DFA98A4DA" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OffMarketLeaseUnfavorable" xlink:label="loc_us-gaap_OffMarketLeaseUnfavorable_A32BA13A34A8EF49D08CA41DFA994BD6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EAC6C132D26EFB4AD783A41DFA98A4DA" xlink:to="loc_us-gaap_OffMarketLeaseUnfavorable_A32BA13A34A8EF49D08CA41DFA994BD6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AmortizationOfUnfavorableLeaseAccrual" xlink:label="loc_pcrx_AmortizationOfUnfavorableLeaseAccrual_A42AC6716C333DDC6226A41DFA9A5CC4" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EAC6C132D26EFB4AD783A41DFA98A4DA" xlink:to="loc_pcrx_AmortizationOfUnfavorableLeaseAccrual_A42AC6716C333DDC6226A41DFA9A5CC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08779A8DA17D8F3AF8BEA41DFA9BB708" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EAC6C132D26EFB4AD783A41DFA98A4DA" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08779A8DA17D8F3AF8BEA41DFA9BB708" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PartiesToContractualArrangementAxis" xlink:label="loc_us-gaap_PartiesToContractualArrangementAxis_972D897EC81A2DF26A68A41DFA9BE3F1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08779A8DA17D8F3AF8BEA41DFA9BB708" xlink:to="loc_us-gaap_PartiesToContractualArrangementAxis_972D897EC81A2DF26A68A41DFA9BE3F1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PartiesToContractualArrangementMember" xlink:label="loc_us-gaap_PartiesToContractualArrangementMember_8F9B82460506E75F8E03A41DFA9BE78F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PartiesToContractualArrangementAxis_972D897EC81A2DF26A68A41DFA9BE3F1" xlink:to="loc_us-gaap_PartiesToContractualArrangementMember_8F9B82460506E75F8E03A41DFA9BE78F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PatheonMember" xlink:label="loc_pcrx_PatheonMember_44E24A8F191D25E6AFEBA41DFA9CF071" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PartiesToContractualArrangementMember_8F9B82460506E75F8E03A41DFA9BE78F" xlink:to="loc_pcrx_PatheonMember_44E24A8F191D25E6AFEBA41DFA9CF071" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_05F840E39227E606DAEBA41DFA9CA916" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08779A8DA17D8F3AF8BEA41DFA9BB708" xlink:to="loc_us-gaap_OperatingLeasedAssetsLineItems_05F840E39227E606DAEBA41DFA9CA916" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EAC6C132D26EFB4AD783A41DFA98A4DA" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_E64C06AE73DF3B5EBB0EA41DFA9FD9E7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_E64C06AE73DF3B5EBB0EA41DFA9FD9E7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_F2E4E9DACF57979EEC41A41DFA9F24C2" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_F2E4E9DACF57979EEC41A41DFA9F24C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_B6C9E2C10F0B8BEBA983A41DFA9F2374" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_B6C9E2C10F0B8BEBA983A41DFA9F2374" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_9BCCED5B28F04716FF7EA41DFA9F899C" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_9BCCED5B28F04716FF7EA41DFA9F899C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_24194B784402268DEC09A41DFAA02EC8" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_24194B784402268DEC09A41DFAA02EC8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_B4CC1C75B09F9E8E845DA41DFAA0F847" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_B4CC1C75B09F9E8E845DA41DFAA0F847" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_FCAB2BDB9FAA30CE22B8A41DFAA01767" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_FCAB2BDB9FAA30CE22B8A41DFAA01767" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLeasesRentExpenseNet" xlink:label="loc_us-gaap_OperatingLeasesRentExpenseNet_B8C51ADC1F1A30BFB7A9A41DFAA11186" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_OperatingLeasesRentExpenseNet_B8C51ADC1F1A30BFB7A9A41DFAA11186" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_214E2F62567D947956FDA41DFAA111F6" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_FD5938C11B01661178B4A41DFA9E304F" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_214E2F62567D947956FDA41DFAA111F6" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommitmentsAndContingenciesDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_481D588204954A385714A41DFA76C345" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MinimumAgeofPediatricPatientstoStudyEXPAREL" xlink:label="loc_pcrx_MinimumAgeofPediatricPatientstoStudyEXPAREL_CDB582E5373781DADF95A41DFA7610B4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_481D588204954A385714A41DFA76C345" xlink:to="loc_pcrx_MinimumAgeofPediatricPatientstoStudyEXPAREL_CDB582E5373781DADF95A41DFA7610B4" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MaximumAgeofPediatricPatientstoStudyEXPAREL" xlink:label="loc_pcrx_MaximumAgeofPediatricPatientstoStudyEXPAREL_EF603DCCCBDEA82E7399A41DFA77AD6C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_481D588204954A385714A41DFA76C345" xlink:to="loc_pcrx_MaximumAgeofPediatricPatientstoStudyEXPAREL_EF603DCCCBDEA82E7399A41DFA77AD6C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AgeofChildrenPediatricPatientstoStudyEXPAREL" xlink:label="loc_pcrx_AgeofChildrenPediatricPatientstoStudyEXPAREL_D06FE9A9F5D5E0DE3CC0A41DFA774980" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_481D588204954A385714A41DFA76C345" xlink:to="loc_pcrx_AgeofChildrenPediatricPatientstoStudyEXPAREL_D06FE9A9F5D5E0DE3CC0A41DFA774980" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommitmentsAndContingenciesDetails3" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_02A899FE2675ABBD2C926F31F5B0C3CE" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_02A899FE2675ABBD2C926F31F5B0C3CE" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_69F712E46533BCD9E99B6F31F5B14A7F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_69F712E46533BCD9E99B6F31F5B14A7F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_68B153B7D0E3B7BB8DA96F31F5B1451F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_69F712E46533BCD9E99B6F31F5B14A7F" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_68B153B7D0E3B7BB8DA96F31F5B1451F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CaliforniaOperatingSubsidiaryMember" xlink:label="loc_pcrx_CaliforniaOperatingSubsidiaryMember_528E6425F347F1700E6A6F31F5B17DBE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_68B153B7D0E3B7BB8DA96F31F5B1451F" xlink:to="loc_pcrx_CaliforniaOperatingSubsidiaryMember_528E6425F347F1700E6A6F31F5B17DBE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_4A7BFBED1893999C979A6F31F5B15CC0" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:to="loc_us-gaap_CounterpartyNameAxis_4A7BFBED1893999C979A6F31F5B15CC0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_FCFCC06D6C8F881BFB6F6F31F5B1CBAE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CounterpartyNameAxis_4A7BFBED1893999C979A6F31F5B15CC0" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_FCFCC06D6C8F881BFB6F6F31F5B1CBAE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SkyePharmaHoldingIncMember" xlink:label="loc_pcrx_SkyePharmaHoldingIncMember_14B2F1E144CBE012ED566F31F5B10EF5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_FCFCC06D6C8F881BFB6F6F31F5B1CBAE" xlink:to="loc_pcrx_SkyePharmaHoldingIncMember_14B2F1E144CBE012ED566F31F5B10EF5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_37AD47635578ED9EFFC96F31F5B1BBF3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:to="loc_us-gaap_RangeAxis_37AD47635578ED9EFFC96F31F5B1BBF3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_FAA10B06EA5BFCDF74AB6F31F5B24C68" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_37AD47635578ED9EFFC96F31F5B1BBF3" xlink:to="loc_us-gaap_RangeMember_FAA10B06EA5BFCDF74AB6F31F5B24C68" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_7A48611194A126BF07846F31F5B24818" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_FAA10B06EA5BFCDF74AB6F31F5B24C68" xlink:to="loc_us-gaap_MaximumMember_7A48611194A126BF07846F31F5B24818" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_4504BA6D80576BF678006F31F5B12D7D" xlink:to="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_0EE42EC8235DB9D7081B6F31F5B3EDA7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_0EE42EC8235DB9D7081B6F31F5B3EDA7" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition" xlink:label="loc_pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition_5CF2A49252C1BAA827FA6F31F5B30F19" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:to="loc_pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition_5CF2A49252C1BAA827FA6F31F5B30F19" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TotalMilestonePaymentsPaidforSaleofProductinConnectionwithAcquisition" xlink:label="loc_pcrx_TotalMilestonePaymentsPaidforSaleofProductinConnectionwithAcquisition_D78163A9B7ECDABCEC9E6F31F5B344DF" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:to="loc_pcrx_TotalMilestonePaymentsPaidforSaleofProductinConnectionwithAcquisition_D78163A9B7ECDABCEC9E6F31F5B344DF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PercentageOfRoyaltyOnSaleOfProduct" xlink:label="loc_pcrx_PercentageOfRoyaltyOnSaleOfProduct_AB44F9AFFD398A55841F6F31F5B3960B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_5068E703DD2C2C09C7C16F31F5B3CA78" xlink:to="loc_pcrx_PercentageOfRoyaltyOnSaleOfProduct_AB44F9AFFD398A55841F6F31F5B3960B" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/CommitmentsAndContingenciesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_D05B53823CB98F9C007B6F31F60841C3" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_2F6894CC76F961F8D8116F31F609D6E0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_D05B53823CB98F9C007B6F31F60841C3" xlink:to="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_2F6894CC76F961F8D8116F31F609D6E0" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_79EDFD87E92027A80497A2C0447ABC78" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_79EDFD87E92027A80497A2C0447ABC78" xlink:to="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_C35DC8C2B873361ADA63A2C0447B4A67" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_C35DC8C2B873361ADA63A2C0447B4A67" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_14C69B0CB83D00DD768FA2C0447B3E81" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_14C69B0CB83D00DD768FA2C0447B3E81" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_84DDDDB57356164BDD83A2C0447C8CF0" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_ShortTermInvestments_84DDDDB57356164BDD83A2C0447C8CF0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_BF0D079D5F5C8142EA51A2C0447CA9AB" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_BF0D079D5F5C8142EA51A2C0447CA9AB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_EFFE2EF6EC6C462587F4A2C0447CCA22" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_InventoryNet_EFFE2EF6EC6C462587F4A2C0447CCA22" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_D21285FAD83775AE3D5FA2C0447CE645" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_D21285FAD83775AE3D5FA2C0447CE645" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_7C9CCE25137B0ABA4BADA2C0447C1A31" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_CA200E9B7309950DBC97A2C0447B99A0" xlink:to="loc_us-gaap_AssetsCurrent_7C9CCE25137B0ABA4BADA2C0447C1A31" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_5549E2D95B3F39880E1BA2C0447DA256" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_LongTermInvestments_5549E2D95B3F39880E1BA2C0447DA256" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_B2B790ED174A4151F09AA2C0447D6A4A" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_B2B790ED174A4151F09AA2C0447D6A4A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_52016C4CF85803D78DD3A2C0447DBDA1" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_Goodwill_52016C4CF85803D78DD3A2C0447DBDA1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_73CB3EEA90CAE23063B5A2C0447D78CF" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_73CB3EEA90CAE23063B5A2C0447D78CF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_E333329EFBFE0FAAC088A2C0447D76A8" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_E333329EFBFE0FAAC088A2C0447D76A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_6AA410D28346AB7F3D36A2C0447D141B" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_E4964C0F12CFE5965114A2C0447BF69F" xlink:to="loc_us-gaap_Assets_6AA410D28346AB7F3D36A2C0447D141B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_79EDFD87E92027A80497A2C0447ABC78" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_3225D0629BA5276F1675A2C0447E8775" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_us-gaap_AccountsPayableCurrent_3225D0629BA5276F1675A2C0447E8775" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_559F65A0105C03301B32A2C0447E790B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_559F65A0105C03301B32A2C0447E790B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtCurrent" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_7B9B74302AD6D4859EC9A2C0447E2F87" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_7B9B74302AD6D4859EC9A2C0447E2F87" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RoyaltyInterestObligationCurrent" xlink:label="loc_pcrx_RoyaltyInterestObligationCurrent_0EAE921569A2544F97D2A2C0447EF20A" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_pcrx_RoyaltyInterestObligationCurrent_0EAE921569A2544F97D2A2C0447EF20A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_948B941D57CB1DB0833DA2C0447E8043" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_us-gaap_DeferredRevenueCurrent_948B941D57CB1DB0833DA2C0447E8043" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_66EBD0421895B583B271A2C0447FB822" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_343E4AE66F389010C887A2C0447E4AC5" xlink:to="loc_us-gaap_LiabilitiesCurrent_66EBD0421895B583B271A2C0447FB822" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RoyaltyInterestObligationNoncurrent" xlink:label="loc_pcrx_RoyaltyInterestObligationNoncurrent_B1AD9BBA49E82AE6CCB8A2C0447FA3EE" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_pcrx_RoyaltyInterestObligationNoncurrent_B1AD9BBA49E82AE6CCB8A2C0447FA3EE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_8620AE276AAA89E498B3A2C0447F9030" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_8620AE276AAA89E498B3A2C0447F9030" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_7B194E3906B7CBDF6A97A2C0447F33B7" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_7B194E3906B7CBDF6A97A2C0447F33B7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_F9DEB0B485089E70B76FA2C0447FA66A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_Liabilities_F9DEB0B485089E70B76FA2C0447FA66A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_24B285229D8B2F2B5F78A2C0447F5BBB" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_CommitmentsAndContingencies_24B285229D8B2F2B5F78A2C0447F5BBB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_D64A800B14417DAA5F89A2C044805116" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_PreferredStockValue_D64A800B14417DAA5F89A2C044805116" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_DE43C4536FFEA788873AA2C04480CB7A" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_CommonStockValue_DE43C4536FFEA788873AA2C04480CB7A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_C1AE3B850DD2A8A23CF1A2C04480EE01" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_AdditionalPaidInCapital_C1AE3B850DD2A8A23CF1A2C04480EE01" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_BE391EF7B5D0E0D0F301A2C044805B06" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_BE391EF7B5D0E0D0F301A2C044805B06" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_CA71D91CBBD7202190B3A2C044812A75" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_CA71D91CBBD7202190B3A2C044812A75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_CAD6AF5E0582F74A253FA2C04481F5CC" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_57DAC02E0D6FE958B460A2C0448064C1" xlink:to="loc_us-gaap_StockholdersEquity_CAD6AF5E0582F74A253FA2C04481F5CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_C28387233091B418C39CA2C044810C0E" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_D15AD876DD9630813B02A2C0447DCA8A" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_C28387233091B418C39CA2C044810C0E" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3E690681F8CC3F5A3DC26F31F4A25220" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3E690681F8CC3F5A3DC26F31F4A25220" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_5BD53FA5085F827943716F31F4A27E8F" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_5BD53FA5085F827943716F31F4A27E8F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_FA7E2B6691E161BF35726F31F4A28F28" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_PreferredStockSharesIssued_FA7E2B6691E161BF35726F31F4A28F28" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_B6215BF4AD5CB3BD52956F31F4A203A0" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_B6215BF4AD5CB3BD52956F31F4A203A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_48DE48B144AF3C4BFEEF6F31F4A31ED5" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_48DE48B144AF3C4BFEEF6F31F4A31ED5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_9004B14E9EF6707502D66F31F4A39CA1" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_9004B14E9EF6707502D66F31F4A39CA1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_3C3A90ACF9F1728BAD926F31F4A3570A" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_CommonStockSharesIssued_3C3A90ACF9F1728BAD926F31F4A3570A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7027FE24E972D6943E4A6F31F4A3A61D" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7027FE24E972D6943E4A6F31F4A3A61D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_7DCDF17AD10E7903A18C6F31F4A338EA" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_EF8D73B3D0B3A9216CAF6F31F4A26598" xlink:to="loc_us-gaap_TreasuryStockShares_7DCDF17AD10E7903A18C6F31F4A338EA" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_4CFCD2FC2EBBFA97663FA41DFFE8498C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:to="loc_us-gaap_NetIncomeLoss_4CFCD2FC2EBBFA97663FA41DFFE8498C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_9DCB702506BC2DE2DEFAA41DFFE9929F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_9DCB702506BC2DE2DEFAA41DFFE9929F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AmortizationOfOtherAssetsAndUnfavorableLeaseObligation" xlink:label="loc_pcrx_AmortizationOfOtherAssetsAndUnfavorableLeaseObligation_02CE82000A09F34884B9A41DFFE9FCAE" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_pcrx_AmortizationOfOtherAssetsAndUnfavorableLeaseObligation_02CE82000A09F34884B9A41DFFE9FCAE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_62B805EA613DF289210DA41DFFE93EC3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_62B805EA613DF289210DA41DFFE93EC3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets_59C7DF5AAF817A27813CA41DFFEA3206" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets_59C7DF5AAF817A27813CA41DFFEA3206" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8B3F10F13389C3988DFBA41DFFEA9608" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8B3F10F13389C3988DFBA41DFFEA9608" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_4E3D4FA2E5AA24154AB4A41DFFEBFF8C" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_9291B1C9BD64B0E5B435A41DFFE9D6CC" xlink:to="loc_us-gaap_ShareBasedCompensation_4E3D4FA2E5AA24154AB4A41DFFEBFF8C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_AAEAFB5B8F0CC6DBDE5FA41DFFEB7725" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInRestrictedCash_AAEAFB5B8F0CC6DBDE5FA41DFFEB7725" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_97EFBB17CFDA46E72D6CA41DFFECEFED" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_97EFBB17CFDA46E72D6CA41DFFECEFED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_3C2E4159410F8DC25ED1A41DFFECD9BC" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_3C2E4159410F8DC25ED1A41DFFECD9BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_72441FE246C26EF473BAA41DFFEDE80A" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_72441FE246C26EF473BAA41DFFEDE80A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_C5F54368CEA4125AA5FEA41DFFED99D1" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_C5F54368CEA4125AA5FEA41DFFED99D1" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_IncreaseDecreaseInRoyaltyInterestObligation" xlink:label="loc_pcrx_IncreaseDecreaseInRoyaltyInterestObligation_1CB9FD48CE0E042BA19AA41DFFEDB67B" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_pcrx_IncreaseDecreaseInRoyaltyInterestObligation_1CB9FD48CE0E042BA19AA41DFFEDB67B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_7BA767B4ADED86C511D3A41DFFEDA221" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_7BA767B4ADED86C511D3A41DFFEDA221" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_9B0F90ACCCE41E2E2E45A41DFFED0441" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5E29C08BEAFDDB69E494A41DFFEB6CC9" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_9B0F90ACCCE41E2E2E45A41DFFED0441" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_60CD4F65FE24D5913D13A41DFFEE520F" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_E0D8B10AFC9C838584D4A41DFFE878A9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_60CD4F65FE24D5913D13A41DFFEE520F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_E7E1563541D51B53E836A41DFFEE4858" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_E7E1563541D51B53E836A41DFFEE4858" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_A7535F87CE2506F707B3A41DFFEF2396" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_A7535F87CE2506F707B3A41DFFEF2396" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_FC4BD318405A2F3D6BE2A41DFFEF88D9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_FC4BD318405A2F3D6BE2A41DFFEF88D9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_922B232C1CBF4480DCE8A41DFFEF2A98" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_922B232C1CBF4480DCE8A41DFFEF2A98" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsToAcquireLongtermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_F5A87FAF961A1514CE4BA41DFFEF1905" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_F5A87FAF961A1514CE4BA41DFFEF1905" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PaymentOfContingentConsideration" xlink:label="loc_pcrx_PaymentOfContingentConsideration_99FBA7D868CB2AAC0FB2A41DFFF09C1F" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_pcrx_PaymentOfContingentConsideration_99FBA7D868CB2AAC0FB2A41DFFF09C1F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_CF9AB41268E4E874A12BA41DFFF0E8C2" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_7253E4768EF681B39DBDA41DFFEE0033" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_CF9AB41268E4E874A12BA41DFFF0E8C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodProceedsFollowonPublicOfferingIssues" xlink:label="loc_pcrx_StockIssuedDuringPeriodProceedsFollowonPublicOfferingIssues_035C93F5D82AB87454DCA41DFFF179F7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_pcrx_StockIssuedDuringPeriodProceedsFollowonPublicOfferingIssues_035C93F5D82AB87454DCA41DFFF179F7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_27A7D516C94614738818A41DFFF1F7E9" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_27A7D516C94614738818A41DFFF1F7E9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ProceedsFromSharesIssuedUnderEmployeeStockPurchasePlan" xlink:label="loc_pcrx_ProceedsFromSharesIssuedUnderEmployeeStockPurchasePlan_79EF08A87841C394FAA3A41DFFF28EAE" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_pcrx_ProceedsFromSharesIssuedUnderEmployeeStockPurchasePlan_79EF08A87841C394FAA3A41DFFF28EAE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_2E9EB9DD01D1B3611DA5A41DFFF28ADB" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_2E9EB9DD01D1B3611DA5A41DFFF28ADB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_0793EB75235E45DBCD03A41DFFF2BB92" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_0793EB75235E45DBCD03A41DFFF2BB92" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RepaymentsOfDebt" xlink:label="loc_us-gaap_RepaymentsOfDebt_CA0F8CEA3D3B655FC174A41DFFF27FFB" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_RepaymentsOfDebt_CA0F8CEA3D3B655FC174A41DFFF27FFB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PaymentsOfFinancingCosts" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_909ED8276680A0D76A87A41DFFF35FB5" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_909ED8276680A0D76A87A41DFFF35FB5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_69E1B4277304AC0F7F7FA41DFFF3369F" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_38100AD896A8BF94033CA41DFFF0F4A9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_69E1B4277304AC0F7F7FA41DFFF3369F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetCashProvidedByUsedInContinuingOperations" xlink:label="loc_us-gaap_NetCashProvidedByUsedInContinuingOperations_6BAF57D9C8FE3F679360A41DFFF3D44B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInContinuingOperations_6BAF57D9C8FE3F679360A41DFFF3D44B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_750071E81B9C6CE24714A41DFFF4E304" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_750071E81B9C6CE24714A41DFFF4E304" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1CA6350865F561779E7DA41DFFF4BAF6" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1CA6350865F561779E7DA41DFFF4BAF6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_787A0A3401BAD63A058FA41DFFF44F25" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_787A0A3401BAD63A058FA41DFFF44F25" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestPaid" xlink:label="loc_us-gaap_InterestPaid_AA49A8FBDBD3B7854E94A41DFFF4540B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_787A0A3401BAD63A058FA41DFFF44F25" xlink:to="loc_us-gaap_InterestPaid_AA49A8FBDBD3B7854E94A41DFFF4540B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_E512F8404D69BE235323A41DFFF5F278" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_787A0A3401BAD63A058FA41DFFF44F25" xlink:to="loc_us-gaap_IncomeTaxesPaid_E512F8404D69BE235323A41DFFF5F278" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F2030A3BF3FB055C88CBA41DFFF547C4" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_2116E764245C5C0EB25CA41DFFE7FAA1" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F2030A3BF3FB055C88CBA41DFFF547C4" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EquityComponentofConvertibleDebt" xlink:label="loc_pcrx_EquityComponentofConvertibleDebt_2303D468D2BB69DDE9DFA41DFFF55CB7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F2030A3BF3FB055C88CBA41DFFF547C4" xlink:to="loc_pcrx_EquityComponentofConvertibleDebt_2303D468D2BB69DDE9DFA41DFFF55CB7" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ClassOfWarrantOrRightValueOfWarrantIssuedWithDebt" xlink:label="loc_pcrx_ClassOfWarrantOrRightValueOfWarrantIssuedWithDebt_706FAFF087BFC04E2C77A41DFFF6C285" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F2030A3BF3FB055C88CBA41DFFF547C4" xlink:to="loc_pcrx_ClassOfWarrantOrRightValueOfWarrantIssuedWithDebt_706FAFF087BFC04E2C77A41DFFF6C285" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1D76DCFF0BDB85F884985013BBCB5BBA" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_A50757C0EE7E8DE7FAC85013BBCB8394" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1D76DCFF0BDB85F884985013BBCB5BBA" xlink:to="loc_us-gaap_NetIncomeLoss_A50757C0EE7E8DE7FAC85013BBCB8394" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_6FCE90799AD23C8AE85F5013BBCBDB1B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1D76DCFF0BDB85F884985013BBCB5BBA" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_6FCE90799AD23C8AE85F5013BBCBDB1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_16F3F47D827A760143015013BBCB6939" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_6FCE90799AD23C8AE85F5013BBCBDB1B" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_16F3F47D827A760143015013BBCB6939" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_D2894EB8D7AD0181DC885013BBCBEE00" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_6FCE90799AD23C8AE85F5013BBCBDB1B" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_D2894EB8D7AD0181DC885013BBCBEE00" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_14E14AB2EDA5AD04BD6C5013BBCBF083" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1D76DCFF0BDB85F884985013BBCB5BBA" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_14E14AB2EDA5AD04BD6C5013BBCBF083" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedStatementsOfOperations" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_AE6DB365117DFFDF058CA2C0445E6BBB" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_AE6DB365117DFFDF058CA2C0445E6BBB" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CollaborativeLicensingAndDevelopmentRevenue" xlink:label="loc_pcrx_CollaborativeLicensingAndDevelopmentRevenue_0E81190DE33787C6D1B8A2C0445F7EA9" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:to="loc_pcrx_CollaborativeLicensingAndDevelopmentRevenue_0E81190DE33787C6D1B8A2C0445F7EA9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RoyaltyRevenue" xlink:label="loc_us-gaap_RoyaltyRevenue_F24E2CD2A3433AA4E04AA2C0445F26BA" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:to="loc_us-gaap_RoyaltyRevenue_F24E2CD2A3433AA4E04AA2C0445F26BA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_B30E1F40189C5AC8D518A2C0445F975C" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_9C2848096A80140D6254A2C0445E416F" xlink:to="loc_us-gaap_Revenues_B30E1F40189C5AC8D518A2C0445F975C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingExpensesAbstract" xlink:label="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaap_CostOfRevenue_9CA24811A05D63A855EAA2C0445FFEB9" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:to="loc_us-gaap_CostOfRevenue_9CA24811A05D63A855EAA2C0445FFEB9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_63FDE6C144D3E4C35344A2C0446017D5" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_63FDE6C144D3E4C35344A2C0446017D5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_96F75E12CF0067500D5FA2C04460C5D4" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_96F75E12CF0067500D5FA2C04460C5D4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_4969A24808C6F450ADC1A2C0446063BF" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_06145041D52A863F6CC3A2C0445F90B3" xlink:to="loc_us-gaap_OperatingExpenses_4969A24808C6F450ADC1A2C0446063BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_B680A28E98898C0CCCA7A2C0446024BE" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_OperatingIncomeLoss_B680A28E98898C0CCCA7A2C0446024BE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_20505F48F4BEA451E102A2C044604F3C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_InvestmentIncomeInterest_20505F48F4BEA451E102A2C044604F3C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_DAD32C517B2F1D2D41D7A2C04461F348" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_InterestExpense_DAD32C517B2F1D2D41D7A2C04461F348" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D9261B2004388180BD35A2C04461D8F1" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D9261B2004388180BD35A2C04461D8F1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RoyaltyExpense" xlink:label="loc_us-gaap_RoyaltyExpense_292D66A2A6CCD0CD4320A2C044610340" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_RoyaltyExpense_292D66A2A6CCD0CD4320A2C044610340" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_CA74705517570728EFDDA2C044613C27" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_CA74705517570728EFDDA2C044613C27" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_D83EC88FB9C0D389B777A2C04461CF7F" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_86C4003E3716DE52EBFDA2C044604740" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_D83EC88FB9C0D389B777A2C04461CF7F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_F3A0B688EEF0B722BB83A2C044611C78" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_F3A0B688EEF0B722BB83A2C044611C78" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_0A50D57E34C0BD636815A2C044617486" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_F3A0B688EEF0B722BB83A2C044611C78" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_0A50D57E34C0BD636815A2C044617486" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_12FE6FEC7D42BB10505FA2C04462FB9F" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_NetIncomeLoss_12FE6FEC7D42BB10505FA2C04462FB9F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_2FA20E6414821C32CF1AA2C044623463" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_EarningsPerShareAbstract_2FA20E6414821C32CF1AA2C044623463" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_5400F739B8468FE1B1D4A2C044625F4E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2FA20E6414821C32CF1AA2C044623463" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_5400F739B8468FE1B1D4A2C044625F4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_DE0F146B8C956031C58CA2C044623999" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_827CC1777DA7694621C9A2C0445EE1A4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_DE0F146B8C956031C58CA2C044623999" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_E4B15CB35E1D3DBF3040A2C044625DEE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_DE0F146B8C956031C58CA2C044623999" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_E4B15CB35E1D3DBF3040A2C044625DEE" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/ConsolidatedStatementsOfStockholdersEquityDeficit" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_0F40E47B412D7CEFF071A2C04445BE06" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_D238D04228B4D948C4ECA2C04445E45B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_0F40E47B412D7CEFF071A2C04445BE06" xlink:to="loc_us-gaap_StatementTable_D238D04228B4D948C4ECA2C04445E45B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_785E373B06BB69A51DE7A2C044462FD3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D238D04228B4D948C4ECA2C04445E45B" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_785E373B06BB69A51DE7A2C044462FD3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_785E373B06BB69A51DE7A2C044462FD3" xlink:to="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_3455006D4B9C639C6862A2C04446B314" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:to="loc_us-gaap_CommonStockMember_3455006D4B9C639C6862A2C04446B314" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_78FCE220902D878B1390A2C044469FBF" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_78FCE220902D878B1390A2C044469FBF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_A3E0A4E1A65436F20DA6A2C04446CBA6" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:to="loc_us-gaap_RetainedEarningsMember_A3E0A4E1A65436F20DA6A2C04446CBA6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_E139C5C25EA188A17F2EA2C044465D34" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:to="loc_us-gaap_TreasuryStockMember_E139C5C25EA188A17F2EA2C044465D34" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4C8965369C035B6A9F3AA2C04446B653" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9F3216E0E3B8551138C9A2C044463F7F" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4C8965369C035B6A9F3AA2C04446B653" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_90FBA7762822F68E5B28A2C044470F93" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D238D04228B4D948C4ECA2C04445E45B" xlink:to="loc_us-gaap_DebtInstrumentAxis_90FBA7762822F68E5B28A2C044470F93" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_C3EDA4ED655FF53D9261A2C04447F765" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_90FBA7762822F68E5B28A2C044470F93" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_C3EDA4ED655FF53D9261A2C04447F765" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandNineConvertibleNotesMember" xlink:label="loc_pcrx_TwoThousandNineConvertibleNotesMember_21EA173782A26FC7D9EDA2C04447C16F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_C3EDA4ED655FF53D9261A2C04447F765" xlink:to="loc_pcrx_TwoThousandNineConvertibleNotesMember_21EA173782A26FC7D9EDA2C04447C16F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandNineSecuredNotesMember" xlink:label="loc_pcrx_TwoThousandNineSecuredNotesMember_5A89F3BBF5DE7AB11312A2C04447C0B3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_C3EDA4ED655FF53D9261A2C04447F765" xlink:to="loc_pcrx_TwoThousandNineSecuredNotesMember_5A89F3BBF5DE7AB11312A2C04447C0B3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_HbmSecuredNotesMember" xlink:label="loc_pcrx_HbmSecuredNotesMember_0FAFD783165B596287BFA2C044479BBF" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_C3EDA4ED655FF53D9261A2C04447F765" xlink:to="loc_pcrx_HbmSecuredNotesMember_0FAFD783165B596287BFA2C044479BBF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_4A81D28BBE4DFEE46577A2C04447A3A8" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D238D04228B4D948C4ECA2C04445E45B" xlink:to="loc_us-gaap_StatementLineItems_4A81D28BBE4DFEE46577A2C04447A3A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4A81D28BBE4DFEE46577A2C04447A3A8" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_9C204FDAE840E45FB24AA2C0444800D1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockholdersEquity_9C204FDAE840E45FB24AA2C0444800D1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_C33F241A6C1A6B57C7A8A2C04448B7AF" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_SharesOutstanding_C33F241A6C1A6B57C7A8A2C04448B7AF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_78BBF0124669F8140E36A2C04448BF3B" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_78BBF0124669F8140E36A2C04448BF3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_64C6C13171507EE6F287A2C0444814ED" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_78BBF0124669F8140E36A2C04448BF3B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_64C6C13171507EE6F287A2C0444814ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_C9E8B85AB1253E0A1E07A2C04448FA75" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_C9E8B85AB1253E0A1E07A2C04448FA75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_D724A4A995162DFF7B30A2C0444814AC" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_D724A4A995162DFF7B30A2C0444814AC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodValueWarrantsExercised" xlink:label="loc_pcrx_StockIssuedDuringPeriodValueWarrantsExercised_641BF97F220B47BDA31CA2C0444887E6" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_StockIssuedDuringPeriodValueWarrantsExercised_641BF97F220B47BDA31CA2C0444887E6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodSharesWarrantsExercised" xlink:label="loc_pcrx_StockIssuedDuringPeriodSharesWarrantsExercised_6EB70EED81E31926EE7EA2C0444862BD" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StockIssuedDuringPeriodValueWarrantsExercised_641BF97F220B47BDA31CA2C0444887E6" xlink:to="loc_pcrx_StockIssuedDuringPeriodSharesWarrantsExercised_6EB70EED81E31926EE7EA2C0444862BD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_82FB61BD84E9D0A52CC8A2C044496072" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_82FB61BD84E9D0A52CC8A2C044496072" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_33B00BD85FAB560EB33FA2C04449DCF6" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_33B00BD85FAB560EB33FA2C04449DCF6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D77F5BEC82EFD871BCDDA2C04449BEDF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_33B00BD85FAB560EB33FA2C04449DCF6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_D77F5BEC82EFD871BCDDA2C04449BEDF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodValueFollowOnPublicOfferingIssues" xlink:label="loc_pcrx_StockIssuedDuringPeriodValueFollowOnPublicOfferingIssues_3282CD997F9C51025A8BA2C04449E9FB" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_StockIssuedDuringPeriodValueFollowOnPublicOfferingIssues_3282CD997F9C51025A8BA2C04449E9FB" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues" xlink:label="loc_pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues_1AA1829994609DCF99A9A2C04449C40B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StockIssuedDuringPeriodValueFollowOnPublicOfferingIssues_3282CD997F9C51025A8BA2C04449E9FB" xlink:to="loc_pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues_1AA1829994609DCF99A9A2C04449C40B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConversionOfConvertibleNotesValue" xlink:label="loc_pcrx_ConversionOfConvertibleNotesValue_D602B8173553CA3A0146A2C044490599" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_ConversionOfConvertibleNotesValue_D602B8173553CA3A0146A2C044490599" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConversionOfConvertibleNotesShares" xlink:label="loc_pcrx_ConversionOfConvertibleNotesShares_DF635FB03C5B15B28E5EA2C04449168F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ConversionOfConvertibleNotesValue_D602B8173553CA3A0146A2C044490599" xlink:to="loc_pcrx_ConversionOfConvertibleNotesShares_DF635FB03C5B15B28E5EA2C04449168F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConversionOfSecuredNotesValue" xlink:label="loc_pcrx_ConversionOfSecuredNotesValue_1D65F635EADA4EEFBA69A2C0444A3C95" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_ConversionOfSecuredNotesValue_1D65F635EADA4EEFBA69A2C0444A3C95" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConversionOfSecuredNotesShares" xlink:label="loc_pcrx_ConversionOfSecuredNotesShares_F13D461CE0A816D261DCA2C0444A35D3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ConversionOfSecuredNotesValue_1D65F635EADA4EEFBA69A2C0444A3C95" xlink:to="loc_pcrx_ConversionOfSecuredNotesShares_F13D461CE0A816D261DCA2C0444A35D3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_C5C06AA11E3469C20A59A2C0444A0F65" xlink:type="locator"/>
<presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_C5C06AA11E3469C20A59A2C0444A0F65" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtIssuanceOnIssuanceOfWarrantsValue" xlink:label="loc_pcrx_DebtIssuanceOnIssuanceOfWarrantsValue_BF64184E565024B29B3BA2C0444A5902" xlink:type="locator"/>
<presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_DebtIssuanceOnIssuanceOfWarrantsValue_BF64184E565024B29B3BA2C0444A5902" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_6C5B98341FFBA55C4F74A2C0444A2ED7" xlink:type="locator"/>
<presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_6C5B98341FFBA55C4F74A2C0444A2ED7" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodValueTreasuryStockReissuedforExerciseofStockOptions" xlink:label="loc_pcrx_StockIssuedDuringPeriodValueTreasuryStockReissuedforExerciseofStockOptions_D784604E91C15A5354A9A2C0444A31D2" xlink:type="locator"/>
<presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_pcrx_StockIssuedDuringPeriodValueTreasuryStockReissuedforExerciseofStockOptions_D784604E91C15A5354A9A2C0444A31D2" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions" xlink:label="loc_pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions_F2612126C1CFF7BCD0ACA2C0444AE41F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StockIssuedDuringPeriodValueTreasuryStockReissuedforExerciseofStockOptions_D784604E91C15A5354A9A2C0444A31D2" xlink:to="loc_pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions_F2612126C1CFF7BCD0ACA2C0444AE41F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_053DF79E570ED188145CA2C0444B40E5" xlink:type="locator"/>
<presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_NetIncomeLoss_053DF79E570ED188145CA2C0444B40E5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_C4FF44F6E1D5DDE5E9A1A2C0444BBBEE" xlink:type="locator"/>
<presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_StockholdersEquity_C4FF44F6E1D5DDE5E9A1A2C0444BBBEE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_0865D164610680FD52AAA2C0444B4D78" xlink:type="locator"/>
<presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_9C056AD1AD908AEE8CA8A2C0444752C3" xlink:to="loc_us-gaap_SharesOutstanding_0865D164610680FD52AAA2C0444B4D78" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/Debt" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_CB69E80FBB4309B5CFD86F31F5ECA758" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_251207E35695E88A2AE66F31F5EC6811" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_CB69E80FBB4309B5CFD86F31F5ECA758" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_251207E35695E88A2AE66F31F5EC6811" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/DebtDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_5170B462BCFC0CE46BFF188855614B96" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtFairValue" xlink:label="loc_us-gaap_LongTermDebtFairValue_BBC76C82A7A52F9991F5188855626F19" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_5170B462BCFC0CE46BFF188855614B96" xlink:to="loc_us-gaap_LongTermDebtFairValue_BBC76C82A7A52F9991F5188855626F19" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongtermDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_5170B462BCFC0CE46BFF188855614B96" xlink:to="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_624A3AF63D828CF91DFC188855627AA2" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:to="loc_us-gaap_LongTermDebtCurrent_624A3AF63D828CF91DFC188855627AA2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_A044E68421D72786549718885563EA94" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_A044E68421D72786549718885563EA94" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_9EAD72191202DE0C712C18885563A958" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:to="loc_us-gaap_LongTermDebt_9EAD72191202DE0C712C18885563A958" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RoyaltyInterestObligation" xlink:label="loc_pcrx_RoyaltyInterestObligation_91DF47F377E0DF960ECD18885564E878" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:to="loc_pcrx_RoyaltyInterestObligation_91DF47F377E0DF960ECD18885564E878" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LongTermDebtIncludingRoyaltyInterestObligation" xlink:label="loc_pcrx_LongTermDebtIncludingRoyaltyInterestObligation_99FFDB932536ADD514E1188855646EA0" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_2AE11B6FD9F55D734FB6188855621B8C" xlink:to="loc_pcrx_LongTermDebtIncludingRoyaltyInterestObligation_99FFDB932536ADD514E1188855646EA0" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/DebtDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_AC7701CEAAAD3C84499FB361CE892E30" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_AC7701CEAAAD3C84499FB361CE892E30" xlink:to="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_879C996773552B994660B361CEE66144" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:to="loc_us-gaap_DebtInstrumentAxis_879C996773552B994660B361CEE66144" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_404EECD922F580688B22B361CEE643BE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_879C996773552B994660B361CEE66144" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_404EECD922F580688B22B361CEE643BE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandNineteenSeniorConvertibleNotesMember" xlink:label="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_7B29EC19C0C2A5634CFBB361CEE66EBE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_404EECD922F580688B22B361CEE643BE" xlink:to="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_7B29EC19C0C2A5634CFBB361CEE66EBE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_OxfordNoteMember" xlink:label="loc_pcrx_OxfordNoteMember_1860D87556B479F5C195B361CEE6BBD6" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_404EECD922F580688B22B361CEE643BE" xlink:to="loc_pcrx_OxfordNoteMember_1860D87556B479F5C195B361CEE6BBD6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtConversionAndRedemptionTermsAxis" xlink:label="loc_pcrx_DebtConversionAndRedemptionTermsAxis_E308B79B7E9317F19603B361CEE6908C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:to="loc_pcrx_DebtConversionAndRedemptionTermsAxis_E308B79B7E9317F19603B361CEE6908C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtConversionAndRedemptionTermsDomain" xlink:label="loc_pcrx_DebtConversionAndRedemptionTermsDomain_F4B54A76FBA369F19A1CB361CEE689B0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DebtConversionAndRedemptionTermsAxis_E308B79B7E9317F19603B361CEE6908C" xlink:to="loc_pcrx_DebtConversionAndRedemptionTermsDomain_F4B54A76FBA369F19A1CB361CEE689B0" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtConversionTermsBusinessDayImmediatelyPrecedingAugust12018Member" xlink:label="loc_pcrx_DebtConversionTermsBusinessDayImmediatelyPrecedingAugust12018Member_B56E65DB6FC22BF48FD3B361CEE69E7D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DebtConversionAndRedemptionTermsDomain_F4B54A76FBA369F19A1CB361CEE689B0" xlink:to="loc_pcrx_DebtConversionTermsBusinessDayImmediatelyPrecedingAugust12018Member_B56E65DB6FC22BF48FD3B361CEE69E7D" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtRedemptionTermsOnOrAfterFebruary12017Member" xlink:label="loc_pcrx_DebtRedemptionTermsOnOrAfterFebruary12017Member_35BC1058E222A72C331FB361CEE6B022" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DebtConversionAndRedemptionTermsDomain_F4B54A76FBA369F19A1CB361CEE689B0" xlink:to="loc_pcrx_DebtRedemptionTermsOnOrAfterFebruary12017Member_35BC1058E222A72C331FB361CEE6B022" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_DD6C4CBF50852BF1E6F0B361CEE639CD" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:to="loc_dei_LegalEntityAxis_DD6C4CBF50852BF1E6F0B361CEE639CD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_1905BB8B020ED21B68C7B361CEE614E6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_DD6C4CBF50852BF1E6F0B361CEE639CD" xlink:to="loc_dei_EntityDomain_1905BB8B020ED21B68C7B361CEE614E6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AffiliateOfPaulCapitalAdvisorsLLCMember" xlink:label="loc_pcrx_AffiliateOfPaulCapitalAdvisorsLLCMember_40EED5A4F945E2D87C83B361CEE66129" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_1905BB8B020ED21B68C7B361CEE614E6" xlink:to="loc_pcrx_AffiliateOfPaulCapitalAdvisorsLLCMember_40EED5A4F945E2D87C83B361CEE66129" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_CD36E238C226D716259DB361CEE6FCA7" xlink:to="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_GrossProceedsFromIssuanceofDebt" xlink:label="loc_pcrx_GrossProceedsFromIssuanceofDebt_554E7CDBCFE9CB7C215CB36AE3E255C7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_pcrx_GrossProceedsFromIssuanceofDebt_554E7CDBCFE9CB7C215CB36AE3E255C7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentsAbstract" xlink:label="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_F4B31AC89FD1B201724BB361CEE64241" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_F4B31AC89FD1B201724BB361CEE64241" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_149DF86F8EFB74C5C8E2B361CEE6F926" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_149DF86F8EFB74C5C8E2B361CEE6F926" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:label="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_1DF7FD9B1F64401903BEB361CEE6BC4F" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_1DF7FD9B1F64401903BEB361CEE6BC4F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentDecreaseRepaymentsOfRemainingPrincipalAmount" xlink:label="loc_pcrx_DebtInstrumentDecreaseRepaymentsOfRemainingPrincipalAmount_BC2C48F46E70C9E23D19B361CEE6E955" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentDecreaseRepaymentsOfRemainingPrincipalAmount_BC2C48F46E70C9E23D19B361CEE6E955" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentDecreaseRepaymentsEndOfTermFees" xlink:label="loc_pcrx_DebtInstrumentDecreaseRepaymentsEndOfTermFees_3E3709BFB74AF04F05C9B361CEE6E8D9" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentDecreaseRepaymentsEndOfTermFees_3E3709BFB74AF04F05C9B361CEE6E8D9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentDecreaseRepaymentsPrepaymentFees" xlink:label="loc_pcrx_DebtInstrumentDecreaseRepaymentsPrepaymentFees_130FADAEBF34A2E183CFB361CEE66130" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentDecreaseRepaymentsPrepaymentFees_130FADAEBF34A2E183CFB361CEE66130" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentDecreaseRepaymentsOfAccruedInterest" xlink:label="loc_pcrx_DebtInstrumentDecreaseRepaymentsOfAccruedInterest_EC05A6597C1FBAB973CFB361CEE60EB3" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentDecreaseRepaymentsOfAccruedInterest_EC05A6597C1FBAB973CFB361CEE60EB3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_63C84CCD6F11F0F14936B361CEE6C24E" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_63C84CCD6F11F0F14936B361CEE6C24E" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumNumberofTradingDays" xlink:label="loc_pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumNumberofTradingDays_A5DCAE743509F7224D59B361CEE6D96A" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumNumberofTradingDays_A5DCAE743509F7224D59B361CEE6D96A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveTradingDays" xlink:label="loc_pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveTradingDays_AA48D60584FDBA3AE6FDB361CEE693FD" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveTradingDays_AA48D60584FDBA3AE6FDB361CEE693FD" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumAsPercentageOfConversionPrice" xlink:label="loc_pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumAsPercentageOfConversionPrice_E7752CFD4892F0C91807B361CEE62620" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationCommonStockClosingSalesPriceMinimumAsPercentageOfConversionPrice_E7752CFD4892F0C91807B361CEE62620" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveBusinessDaysAfterConsecutiveTradingDayPeriod" xlink:label="loc_pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveBusinessDaysAfterConsecutiveTradingDayPeriod_6CBF3D480C4F19BF9F85B361CEE691EF" xlink:type="locator"/>
<presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveBusinessDaysAfterConsecutiveTradingDayPeriod_6CBF3D480C4F19BF9F85B361CEE691EF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationPeriodOfConsecutiveTradingDays" xlink:label="loc_pcrx_DebtInstrumentConversionObligationPeriodOfConsecutiveTradingDays_D89FC413F91764448E9AB361CEE60204" xlink:type="locator"/>
<presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationPeriodOfConsecutiveTradingDays_D89FC413F91764448E9AB361CEE60204" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentPrincipalAmountDenominatorForConversionIntoCommonStock" xlink:label="loc_pcrx_DebtInstrumentPrincipalAmountDenominatorForConversionIntoCommonStock_01FA17AA7DC3C315AD8BB361CEE6A5CC" xlink:type="locator"/>
<presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentPrincipalAmountDenominatorForConversionIntoCommonStock_01FA17AA7DC3C315AD8BB361CEE6A5CC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationTradingPriceAsPercentageOfProductOfLastReportedCommonStockSalePriceAndConversionRateMaximum" xlink:label="loc_pcrx_DebtInstrumentConversionObligationTradingPriceAsPercentageOfProductOfLastReportedCommonStockSalePriceAndConversionRateMaximum_4F17DB3DD5F15AC84B80B361CEE6DB8B" xlink:type="locator"/>
<presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationTradingPriceAsPercentageOfProductOfLastReportedCommonStockSalePriceAndConversionRateMaximum_4F17DB3DD5F15AC84B80B361CEE6DB8B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_540797A32F235ED0BF91B361CEE677F0" xlink:type="locator"/>
<presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_540797A32F235ED0BF91B361CEE677F0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_5B73829DC18DB2E72D1EB361CEE672F1" xlink:type="locator"/>
<presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_5B73829DC18DB2E72D1EB361CEE672F1" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationPremiumOnCommonStock" xlink:label="loc_pcrx_DebtInstrumentConversionObligationPremiumOnCommonStock_2D0D25D3E4E065B61DB2B361CEE6C76F" xlink:type="locator"/>
<presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationPremiumOnCommonStock_2D0D25D3E4E065B61DB2B361CEE6C76F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_ADD3443C877A2512BE33B361CEE67A03" xlink:type="locator"/>
<presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_SharePrice_ADD3443C877A2512BE33B361CEE67A03" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentMarketPrice" xlink:label="loc_pcrx_DebtInstrumentMarketPrice_DF789CBC2763F34F0BF8B361CEE6FAB8" xlink:type="locator"/>
<presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentMarketPrice_DF789CBC2763F34F0BF8B361CEE6FAB8" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleConversionValue" xlink:label="loc_pcrx_DebtInstrumentConvertibleConversionValue_213BB6C906691A29F0FFB361CEE6F5E7" xlink:type="locator"/>
<presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConvertibleConversionValue_213BB6C906691A29F0FFB361CEE6F5E7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_9EC4813DC2ED9F51DFE9B361CEE6D559" xlink:type="locator"/>
<presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_9EC4813DC2ED9F51DFE9B361CEE6D559" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConversionObligationNumberofTradingDaysPriortoDateonwhichEntityProvidesNoticeofRedemption" xlink:label="loc_pcrx_DebtInstrumentConversionObligationNumberofTradingDaysPriortoDateonwhichEntityProvidesNoticeofRedemption_82AF1D241D5622C60AC8B361CEE6C53F" xlink:type="locator"/>
<presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConversionObligationNumberofTradingDaysPriortoDateonwhichEntityProvidesNoticeofRedemption_82AF1D241D5622C60AC8B361CEE6C53F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentPercentageOfPrincipalAmountForComputationOfRedemptionPrice" xlink:label="loc_pcrx_DebtInstrumentPercentageOfPrincipalAmountForComputationOfRedemptionPrice_E84BCEDA8DA940C1D1EFB361CEE6EA87" xlink:type="locator"/>
<presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentPercentageOfPrincipalAmountForComputationOfRedemptionPrice_E84BCEDA8DA940C1D1EFB361CEE6EA87" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtRedemptionPriceDueToFundamentalChangeAsPercentageOfPrincipalAmount" xlink:label="loc_pcrx_DebtRedemptionPriceDueToFundamentalChangeAsPercentageOfPrincipalAmount_4E351EE0C7B9747A49CAB361CEE6CDEE" xlink:type="locator"/>
<presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtRedemptionPriceDueToFundamentalChangeAsPercentageOfPrincipalAmount_4E351EE0C7B9747A49CAB361CEE6CDEE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleEventOfDefaultBankruptcyPercentageOfPrincipalPayableAndDue" xlink:label="loc_pcrx_DebtInstrumentConvertibleEventOfDefaultBankruptcyPercentageOfPrincipalPayableAndDue_A46F256DBA7EC3BFB609B361CEE67CDD" xlink:type="locator"/>
<presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_pcrx_DebtInstrumentConvertibleEventOfDefaultBankruptcyPercentageOfPrincipalPayableAndDue_A46F256DBA7EC3BFB609B361CEE67CDD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebt" xlink:label="loc_us-gaap_ConvertibleDebt_D9A0DA74F873B2090202B361CEE6BD9F" xlink:type="locator"/>
<presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_ConvertibleDebt_D9A0DA74F873B2090202B361CEE6BD9F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtIssuanceCosts" xlink:label="loc_us-gaap_DebtIssuanceCosts_754CCB0389446E9638B4B361CEE66319" xlink:type="locator"/>
<presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtIssuanceCosts_754CCB0389446E9638B4B361CEE66319" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentTerm" xlink:label="loc_us-gaap_DebtInstrumentTerm_ADE6125CE100DF138C28B361CEE6F9A2" xlink:type="locator"/>
<presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_DebtInstrumentTerm_ADE6125CE100DF138C28B361CEE6F9A2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpenseDebtAbstract" xlink:label="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:type="locator"/>
<presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_025A03BDDFF9E4A940A2B361CEE65D80" xlink:to="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpenseDebtExcludingAmortization" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_A348FCE0DD16C401DED5B361CEE677EF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_A348FCE0DD16C401DED5B361CEE677EF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_B8FDABD53E6462C297D0B361CEE6A15B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_B8FDABD53E6462C297D0B361CEE6A15B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_DF0FCBBEDA13AFDCB321B361CEE69E68" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_DF0FCBBEDA13AFDCB321B361CEE69E68" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestExpenseDebt" xlink:label="loc_us-gaap_InterestExpenseDebt_E70CFCE2099B32A285F2B361CEE6E94B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:to="loc_us-gaap_InterestExpenseDebt_E70CFCE2099B32A285F2B361CEE6E94B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_F3BD40618AE535953B1DB361CEE6A7B5" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_32C5A79F3D2327F97CECB361CEE62B80" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_F3BD40618AE535953B1DB361CEE6A7B5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermNotesPayableAbstract" xlink:label="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_16403CAF2A5AD472B61DB361CEE6757E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_16403CAF2A5AD472B61DB361CEE6757E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D7443CAB33062F71444DB361CEE677E0" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D7443CAB33062F71444DB361CEE677E0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights_6E7BEB0A1C7FD3D441C2B361CEE67777" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights_6E7BEB0A1C7FD3D441C2B361CEE67777" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract" xlink:label="loc_us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract_2A5847684B6532D53028B361CEE6C382" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermNotesPayableAbstract_95E2E45C4E395E401A1EB361CEE60544" xlink:to="loc_us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract_2A5847684B6532D53028B361CEE6C382" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_A67CDE8CC5EDC01D7D83B361CEE610E7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract_2A5847684B6532D53028B361CEE6C382" xlink:to="loc_us-gaap_FairValueInputsDiscountRate_A67CDE8CC5EDC01D7D83B361CEE610E7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermDebtFairValue" xlink:label="loc_us-gaap_LongTermDebtFairValue_6EB5F86C02BA2BBD8B80B361CEE6C382" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract_2A5847684B6532D53028B361CEE6C382" xlink:to="loc_us-gaap_LongTermDebtFairValue_6EB5F86C02BA2BBD8B80B361CEE6C382" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AmountToBeRaisedOnSaleOfRoyaltyInterest" xlink:label="loc_pcrx_AmountToBeRaisedOnSaleOfRoyaltyInterest_89A1E4908726815BCC91B361CEE6B188" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_pcrx_AmountToBeRaisedOnSaleOfRoyaltyInterest_89A1E4908726815BCC91B361CEE6B188" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest" xlink:label="loc_pcrx_NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest_25B55E4ADF4D43CC4CC5B361CEE63BC9" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_pcrx_NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest_25B55E4ADF4D43CC4CC5B361CEE63BC9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NetPresentValueOfRoyaltiesExpectedToBeRepaid" xlink:label="loc_pcrx_NetPresentValueOfRoyaltiesExpectedToBeRepaid_2D39A3E19BB8224F4059B361CEE6D62D" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1BAB56929C3D5D62A318B361CEE64A0F" xlink:to="loc_pcrx_NetPresentValueOfRoyaltiesExpectedToBeRepaid_2D39A3E19BB8224F4059B361CEE6D62D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/DebtTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_4885D035892A61CCD7266F31F714EB1D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfDebtTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock_0DEA2218C32DA05D700B6F31F714E071" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_4885D035892A61CCD7266F31F714EB1D" xlink:to="loc_us-gaap_ScheduleOfDebtTableTextBlock_0DEA2218C32DA05D700B6F31F714E071" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ScheduleOfInterestExpenseTableTextBlock" xlink:label="loc_pcrx_ScheduleOfInterestExpenseTableTextBlock_FE84E5BC5DC8BDD067A86F31F714CBE1" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_4885D035892A61CCD7266F31F714EB1D" xlink:to="loc_pcrx_ScheduleOfInterestExpenseTableTextBlock_FE84E5BC5DC8BDD067A86F31F714CBE1" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/DescriptionOfBusiness" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_9DD94E870F94CA54D3D8A41DFFB225F5" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A2498F0B33959DD333BAA41DFFB2C594" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_9DD94E870F94CA54D3D8A41DFFB225F5" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_A2498F0B33959DD333BAA41DFFB2C594" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/DocumentAndEntityInformation" xlink:type="extended">
<loc xlink:href="pcrx-20141231.xsd#pcrx_DocumentAndEntityInformationAbstract" xlink:label="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:type="locator"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_E05E8F311164519CED2A6F31F61B4E17" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityRegistrantName_E05E8F311164519CED2A6F31F61B4E17" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_F2158643CF9EB9E3675A6F31F61B36B3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityCentralIndexKey_F2158643CF9EB9E3675A6F31F61B36B3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_8181FC313754453A849B6F31F61CA41B" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_DocumentType_8181FC313754453A849B6F31F61CA41B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_9819FE5D3887F2C207FF6F31F61C9A47" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_DocumentPeriodEndDate_9819FE5D3887F2C207FF6F31F61C9A47" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_00A91DBFF56AB002B2686F31F61CB589" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_AmendmentFlag_00A91DBFF56AB002B2686F31F61CB589" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_1A093BB930F6BE8FA63C6F31F61C4797" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_CurrentFiscalYearEndDate_1A093BB930F6BE8FA63C6F31F61C4797" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_F5AEF8FFFF8465E818256F31F61C016F" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_F5AEF8FFFF8465E818256F31F61C016F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_E54BE694DDFEA9A1B0466F31F61CE775" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityVoluntaryFilers_E54BE694DDFEA9A1B0466F31F61CE775" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_7FE2E2A7EAED5D07DE276F31F61C829C" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityCurrentReportingStatus_7FE2E2A7EAED5D07DE276F31F61C829C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_6A51FAF77104471658366F31F61C82B5" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityFilerCategory_6A51FAF77104471658366F31F61C82B5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_48D0C3E66BF826C428E66F31F61CEE82" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityPublicFloat_48D0C3E66BF826C428E66F31F61CEE82" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_B19CEF10D4D67EC80E8D6F31F61D593E" xlink:type="locator"/>
<presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_B19CEF10D4D67EC80E8D6F31F61D593E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_1D3FA0C6198E23A290366F31F61DADB3" xlink:type="locator"/>
<presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_DocumentFiscalYearFocus_1D3FA0C6198E23A290366F31F61DADB3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/dei/2013/dei-2013-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_0A40A3CBBFE85B54CF786F31F61D2BD2" xlink:type="locator"/>
<presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_DocumentAndEntityInformationAbstract_26664D64343DD54A5F5A6F31F61BD64C" xlink:to="loc_dei_DocumentFiscalPeriodFocus_0A40A3CBBFE85B54CF786F31F61D2BD2" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FinancialInstruments" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_137B8243C0295C6A82346F31F59F2BE6" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:label="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_D052B31403C3D2682A326F31F59F9ABC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_137B8243C0295C6A82346F31F59F2BE6" xlink:to="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_D052B31403C3D2682A326F31F59F9ABC" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FinancialInstrumentsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_EE552B09520797BC6052A41DD0BC2FF9" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_EE552B09520797BC6052A41DD0BC2FF9" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_9B18E9A4AC9705F4CDC2A41DD0C51D0E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_9B18E9A4AC9705F4CDC2A41DD0C51D0E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_232353A4EC0BF9E9A16CA43FBE2D1EF3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_9B18E9A4AC9705F4CDC2A41DD0C51D0E" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_232353A4EC0BF9E9A16CA43FBE2D1EF3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_99E8E6848E0F29DAF0ADA41DD0C660FD" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_232353A4EC0BF9E9A16CA43FBE2D1EF3" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_99E8E6848E0F29DAF0ADA41DD0C660FD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_10BB9239984C1B223084A41DD0C73AC4" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_232353A4EC0BF9E9A16CA43FBE2D1EF3" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_10BB9239984C1B223084A41DD0C73AC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_D6023F74C1DBA214D9D5A41DD0C81DB8" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_D6023F74C1DBA214D9D5A41DD0C81DB8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_32416B7AD84298AB2344A41DD0C8DAF2" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_D6023F74C1DBA214D9D5A41DD0C81DB8" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_32416B7AD84298AB2344A41DD0C8DAF2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_AE078C5457A632577F74A41DD0C86C3A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_32416B7AD84298AB2344A41DD0C8DAF2" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_AE078C5457A632577F74A41DD0C86C3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_FED6997597342A50166EA41DD0C99BD7" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_32416B7AD84298AB2344A41DD0C8DAF2" xlink:to="loc_us-gaap_CommercialPaperMember_FED6997597342A50166EA41DD0C99BD7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_9E6B6A34A4D494E082E1A41DD0C9E603" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_32416B7AD84298AB2344A41DD0C8DAF2" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_9E6B6A34A4D494E082E1A41DD0C9E603" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_32FF722AF1014028B99BA41DD0CA9F4B" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_FinancialInstrumentAxis_32FF722AF1014028B99BA41DD0CA9F4B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEB59BCF80B094E49713A41DD0CACD7E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_32FF722AF1014028B99BA41DD0CA9F4B" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEB59BCF80B094E49713A41DD0CACD7E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShortTermInvestmentsMember" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_A21A6A185B2D5CE75DE1A41DD0CB7260" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEB59BCF80B094E49713A41DD0CACD7E" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_A21A6A185B2D5CE75DE1A41DD0CB7260" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LongTermInvestmentsMember" xlink:label="loc_pcrx_LongTermInvestmentsMember_40FF73D6FF5CE6AE1EE4A41DD0CC116B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_FEB59BCF80B094E49713A41DD0CACD7E" xlink:to="loc_pcrx_LongTermInvestmentsMember_40FF73D6FF5CE6AE1EE4A41DD0CC116B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CreditRatingStandardPoorsAxis" xlink:label="loc_us-gaap_CreditRatingStandardPoorsAxis_D860AF947AD16AE5A3F9A41DD0CCC39E" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_CreditRatingStandardPoorsAxis_D860AF947AD16AE5A3F9A41DD0CCC39E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ExternalCreditRatingStandardPoorsMember" xlink:label="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_B3E9E8BB9040E702A737A41DD0CC298F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditRatingStandardPoorsAxis_D860AF947AD16AE5A3F9A41DD0CCC39E" xlink:to="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_B3E9E8BB9040E702A737A41DD0CC298F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StandardPoorsARatingMember" xlink:label="loc_us-gaap_StandardPoorsARatingMember_4F5FA280001B4A9EEC7BA41DD0CD157D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_B3E9E8BB9040E702A737A41DD0CC298F" xlink:to="loc_us-gaap_StandardPoorsARatingMember_4F5FA280001B4A9EEC7BA41DD0CD157D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2F8EA0E9D789D4F4FEF4A41DD0CD589D" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_RangeAxis_2F8EA0E9D789D4F4FEF4A41DD0CD589D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_412956CE49B72755B902A41DD0CD08E5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2F8EA0E9D789D4F4FEF4A41DD0CD589D" xlink:to="loc_us-gaap_RangeMember_412956CE49B72755B902A41DD0CD08E5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_0A85658961AADD835B83A41DD0CE4318" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_412956CE49B72755B902A41DD0CD08E5" xlink:to="loc_us-gaap_MaximumMember_0A85658961AADD835B83A41DD0CE4318" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_58B5EC728FF20F5C4A51A41DD0CEBB45" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_412956CE49B72755B902A41DD0CD08E5" xlink:to="loc_us-gaap_MinimumMember_58B5EC728FF20F5C4A51A41DD0CEBB45" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_40D189C49EF5BD5915D8A41DD0CF034B" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_DebtInstrumentAxis_40D189C49EF5BD5915D8A41DD0CF034B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_CCB6CF106C4E1A3CBCEFA41DD0CF0C8B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_40D189C49EF5BD5915D8A41DD0CF034B" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_CCB6CF106C4E1A3CBCEFA41DD0CF0C8B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandNineteenSeniorConvertibleNotesMember" xlink:label="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_7ED24E4C2A4BF885FD15A41DD0CF7BD4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_CCB6CF106C4E1A3CBCEFA41DD0CF0C8B" xlink:to="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_7ED24E4C2A4BF885FD15A41DD0CF7BD4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_47E11846C5ABBD77E26EA41DD0CF43BB" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_47E11846C5ABBD77E26EA41DD0CF43BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_663E0300F5C44B32138FA41DD0D0993E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_47E11846C5ABBD77E26EA41DD0CF43BB" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_663E0300F5C44B32138FA41DD0D0993E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_F4E9FB2309747DE33E3BA41DD0D06B85" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_663E0300F5C44B32138FA41DD0D0993E" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_F4E9FB2309747DE33E3BA41DD0D06B85" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_80A05A0A2103F1938296A41DD0D1E7E0" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_663E0300F5C44B32138FA41DD0D0993E" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_80A05A0A2103F1938296A41DD0D1E7E0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_960C2732BA4DA78E3588A41DD0D138E3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_663E0300F5C44B32138FA41DD0D0993E" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_960C2732BA4DA78E3588A41DD0D138E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_4C163D346514BEA93F6DA41DD0C35788" xlink:to="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30EFBCDAE9A3A515C9F4A41DD0D26789" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30EFBCDAE9A3A515C9F4A41DD0D26789" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_8D390D18642A480656E2A41DD0D2F742" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_LongTermInvestments_8D390D18642A480656E2A41DD0D2F742" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LongTermInvestmentsMaturityPeriod" xlink:label="loc_pcrx_LongTermInvestmentsMaturityPeriod_1967F86BF869A35E5F12A41DD0D21BD8" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_pcrx_LongTermInvestmentsMaturityPeriod_1967F86BF869A35E5F12A41DD0D21BD8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentFairValue" xlink:label="loc_us-gaap_DebtInstrumentFairValue_CB77FE23E037AE17F2BAA41DD0D34012" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_DebtInstrumentFairValue_CB77FE23E037AE17F2BAA41DD0D34012" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_05D87CCC893BFA912255A41DD0D39D7D" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_SharePrice_05D87CCC893BFA912255A41DD0D39D7D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_F8AFFDD80B36FAB6241DA41DD0D3D548" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_F8AFFDD80B36FAB6241DA41DD0D3D548" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleConversionPremiumShares" xlink:label="loc_pcrx_DebtInstrumentConvertibleConversionPremiumShares_95BA010A32D8E75BECECA41DD0D46899" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_pcrx_DebtInstrumentConvertibleConversionPremiumShares_95BA010A32D8E75BECECA41DD0D46899" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleConversionValue" xlink:label="loc_pcrx_DebtInstrumentConvertibleConversionValue_3948BAE5CC65147F2CBDA41DD0D42E6D" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_pcrx_DebtInstrumentConvertibleConversionValue_3948BAE5CC65147F2CBDA41DD0D42E6D" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments" xlink:label="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_360E849300678FCED941A41DD0D415EC" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_360E849300678FCED941A41DD0D415EC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments" xlink:label="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_9C100DF1BB6B1F2E475AA41DD0D49AC9" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_9C100DF1BB6B1F2E475AA41DD0D49AC9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_0D25DF42D514C77D55D7A41DD0D5BE60" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_32B88E5D93571256A74AA41DD0D14B7E" xlink:to="loc_us-gaap_AvailableForSaleSecurities_0D25DF42D514C77D55D7A41DD0D5BE60" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FinancialInstrumentsDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_972C496A9D9CE2F5C25EA36760F9BC87" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_972C496A9D9CE2F5C25EA36760F9BC87" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_AA7E2DF7332C777C796DA36760FA1BCA" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_FinancialInstrumentAxis_AA7E2DF7332C777C796DA36760FA1BCA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6BAA1283CED5D213640EA36760FA8F71" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_AA7E2DF7332C777C796DA36760FA1BCA" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6BAA1283CED5D213640EA36760FA8F71" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShortTermInvestmentsMember" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_7E26216D38FA246C2468A36760FB4EF5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6BAA1283CED5D213640EA36760FA8F71" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_7E26216D38FA246C2468A36760FB4EF5" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LongTermInvestmentsMember" xlink:label="loc_pcrx_LongTermInvestmentsMember_230D92CFC7368B91F82BA36760FB10B5" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_6BAA1283CED5D213640EA36760FA8F71" xlink:to="loc_pcrx_LongTermInvestmentsMember_230D92CFC7368B91F82BA36760FB10B5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_324A7A4BBA9687C24A76A36760FC4887" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_324A7A4BBA9687C24A76A36760FC4887" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_E2C1C19EFA53EDEC5CB3A36760FC3A3B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_324A7A4BBA9687C24A76A36760FC4887" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_E2C1C19EFA53EDEC5CB3A36760FC3A3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_398E6360C5B3B27D1449A37BE21A0EE7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_E2C1C19EFA53EDEC5CB3A36760FC3A3B" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_398E6360C5B3B27D1449A37BE21A0EE7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_6316D78024D72244EF7AA36760FCD085" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_E2C1C19EFA53EDEC5CB3A36760FC3A3B" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_6316D78024D72244EF7AA36760FCD085" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CreditRatingStandardPoorsAxis" xlink:label="loc_us-gaap_CreditRatingStandardPoorsAxis_037A5DA67222A20AFFFBA36760FCC06D" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_CreditRatingStandardPoorsAxis_037A5DA67222A20AFFFBA36760FCC06D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ExternalCreditRatingStandardPoorsMember" xlink:label="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_672BB04AE119C3CF5E52A36760FCBB5F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditRatingStandardPoorsAxis_037A5DA67222A20AFFFBA36760FCC06D" xlink:to="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_672BB04AE119C3CF5E52A36760FCBB5F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StandardPoorsARatingMember" xlink:label="loc_us-gaap_StandardPoorsARatingMember_B2F4F5C4D48A63A863A7A36760FD5710" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExternalCreditRatingStandardPoorsMember_672BB04AE119C3CF5E52A36760FCBB5F" xlink:to="loc_us-gaap_StandardPoorsARatingMember_B2F4F5C4D48A63A863A7A36760FD5710" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2F7B3FEC43883F599E24A36760FD6962" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_RangeAxis_2F7B3FEC43883F599E24A36760FD6962" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_67EB88F59B89130ED25BA36760FEA8CC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2F7B3FEC43883F599E24A36760FD6962" xlink:to="loc_us-gaap_RangeMember_67EB88F59B89130ED25BA36760FEA8CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_9AB1095B656B03D6EDF8A36760FEDC7A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_67EB88F59B89130ED25BA36760FEA8CC" xlink:to="loc_us-gaap_MinimumMember_9AB1095B656B03D6EDF8A36760FEDC7A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A1D0C061C46F811521BAA36760FEA8CC" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_67EB88F59B89130ED25BA36760FEA8CC" xlink:to="loc_us-gaap_MaximumMember_A1D0C061C46F811521BAA36760FEA8CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_EE7FE0FDA929C07598BBA36760FEB8BC" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_EE7FE0FDA929C07598BBA36760FEB8BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_592A2062CDDAC96E9515A36760FF0C1B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_EE7FE0FDA929C07598BBA36760FEB8BC" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_592A2062CDDAC96E9515A36760FF0C1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_BF54D3C4F7D2CE39E144A36760FF4605" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_592A2062CDDAC96E9515A36760FF0C1B" xlink:to="loc_us-gaap_CommercialPaperMember_BF54D3C4F7D2CE39E144A36760FF4605" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_2E9858E7DE584EE3B450A36761002C15" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_592A2062CDDAC96E9515A36760FF0C1B" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_2E9858E7DE584EE3B450A36761002C15" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_5FA0C158783D68D270AEA36761008BFB" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_592A2062CDDAC96E9515A36760FF0C1B" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_5FA0C158783D68D270AEA36761008BFB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_02E3293759AA64025022A367610064F6" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_02E3293759AA64025022A367610064F6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_52C624C955559C8B7830A3676101765C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_02E3293759AA64025022A367610064F6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_52C624C955559C8B7830A3676101765C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_0E976929EE3DF611C459A3676101A320" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_52C624C955559C8B7830A3676101765C" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_0E976929EE3DF611C459A3676101A320" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5F459A56C99250066584A3676101936E" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_3F00A8111ECE12CF271FA36760FAD5CC" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5F459A56C99250066584A3676101936E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShortTermInvestmentsAbstract" xlink:label="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_5F459A56C99250066584A3676101936E" xlink:to="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_93E01CB3442A95207069A3676102F1D6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_us-gaap_ShortTermInvestments_93E01CB3442A95207069A3676102F1D6" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ShortTermInvestmentsMaturityPeriod" xlink:label="loc_pcrx_ShortTermInvestmentsMaturityPeriod_6B1C8AED747BFA27ECADA36761025F44" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_pcrx_ShortTermInvestmentsMaturityPeriod_6B1C8AED747BFA27ECADA36761025F44" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_AA7333E4118B69A00778A3676103281C" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_AA7333E4118B69A00778A3676103281C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments" xlink:label="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_C8416AE1FC32846E6209A3676103C6B2" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments_C8416AE1FC32846E6209A3676103C6B2" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments" xlink:label="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_26F8EA4EBDE9D9823001A3676103FBD5" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_pcrx_AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments_26F8EA4EBDE9D9823001A3676103FBD5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_5BCB285BBD836ABCB73FA3676103905A" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_64A4C6C4B8996203C74BA3676101F730" xlink:to="loc_us-gaap_AvailableForSaleSecurities_5BCB285BBD836ABCB73FA3676103905A" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FinancialInstrumentsDetails3" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_DE48FE57B2F5F74D8E2BA41DFD6BFCFA" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DE48FE57B2F5F74D8E2BA41DFD6BFCFA" xlink:to="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_F37D65C4D2CE742DEE7EA41DFD6C164C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_F37D65C4D2CE742DEE7EA41DFD6C164C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_C8D61296D7F55BB8B6B3A41DFD6CDB79" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_F37D65C4D2CE742DEE7EA41DFD6C164C" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_C8D61296D7F55BB8B6B3A41DFD6CDB79" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_CB7088EFE321644FB874A41DFD6D419B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_C8D61296D7F55BB8B6B3A41DFD6CDB79" xlink:to="loc_us-gaap_AccountsReceivableMember_CB7088EFE321644FB874A41DFD6D419B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_87F64040964FBAEBF696A41DFD6DB26D" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_87F64040964FBAEBF696A41DFD6DB26D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_D3587382B92F3387701AA41DFD6D4151" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_87F64040964FBAEBF696A41DFD6DB26D" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_D3587382B92F3387701AA41DFD6D4151" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CreditConcentrationRiskMember" xlink:label="loc_us-gaap_CreditConcentrationRiskMember_4BF99F165BB0203F9B0FA41DFD6E665F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_D3587382B92F3387701AA41DFD6D4151" xlink:to="loc_us-gaap_CreditConcentrationRiskMember_4BF99F165BB0203F9B0FA41DFD6E665F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="loc_us-gaap_MajorCustomersAxis_B60D7E5839292576841CA41DFD6F07FE" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:to="loc_us-gaap_MajorCustomersAxis_B60D7E5839292576841CA41DFD6F07FE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="loc_us-gaap_NameOfMajorCustomerDomain_38320FE8718BFAD74D8DA41DFD6F1CCF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorCustomersAxis_B60D7E5839292576841CA41DFD6F07FE" xlink:to="loc_us-gaap_NameOfMajorCustomerDomain_38320FE8718BFAD74D8DA41DFD6F1CCF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MajorCustomerOneMember" xlink:label="loc_pcrx_MajorCustomerOneMember_A3FDC572248B8AD02C74A41DFD70AF56" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_38320FE8718BFAD74D8DA41DFD6F1CCF" xlink:to="loc_pcrx_MajorCustomerOneMember_A3FDC572248B8AD02C74A41DFD70AF56" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MajorCustomerTwoMember" xlink:label="loc_pcrx_MajorCustomerTwoMember_E570E4671336CDAAC526A41DFD7198EE" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_38320FE8718BFAD74D8DA41DFD6F1CCF" xlink:to="loc_pcrx_MajorCustomerTwoMember_E570E4671336CDAAC526A41DFD7198EE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MajorCustomerThreeMember" xlink:label="loc_pcrx_MajorCustomerThreeMember_84201BE7FFE27BC238B5A41DFD719EA3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_38320FE8718BFAD74D8DA41DFD6F1CCF" xlink:to="loc_pcrx_MajorCustomerThreeMember_84201BE7FFE27BC238B5A41DFD719EA3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_FE038B61CBC59367317DA41DFD712A11" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_D55CB8D66028F412C022A41DFD6B38B9" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_FE038B61CBC59367317DA41DFD712A11" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NumberOfMajorCustomers" xlink:label="loc_pcrx_NumberOfMajorCustomers_E3A07581D44CDE677986A41DFD72129B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_FE038B61CBC59367317DA41DFD712A11" xlink:to="loc_pcrx_NumberOfMajorCustomers_E3A07581D44CDE677986A41DFD72129B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_3748CE6A903087375867A41DFD721A67" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_FE038B61CBC59367317DA41DFD712A11" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_3748CE6A903087375867A41DFD721A67" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FinancialInstrumentsTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1FC59434DC850425A6A06F31F6AEBA70" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_C948A7B07DF1A999A7BC6F31F6AEDD3C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1FC59434DC850425A6A06F31F6AEBA70" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_C948A7B07DF1A999A7BC6F31F6AEDD3C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_A7186A39AEC6E57AA9C76F31F6AE1737" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1FC59434DC850425A6A06F31F6AEBA70" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_A7186A39AEC6E57AA9C76F31F6AE1737" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FixedAssets" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_536433E6CD4F7752E4476F31F5871C34" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_6D3DA7EB17F094BB4F936F31F587F02A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_536433E6CD4F7752E4476F31F5871C34" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_6D3DA7EB17F094BB4F936F31F587F02A" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FixedAssetsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_BF5F212C7E02F12225B9A41DFEEB4FC1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_A3295FA97E026CCE741DA41DFEEC643B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_BF5F212C7E02F12225B9A41DFEEB4FC1" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_A3295FA97E026CCE741DA41DFEEC643B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4B6044D186B16C814A3AA41DFEEC2796" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_A3295FA97E026CCE741DA41DFEEC643B" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4B6044D186B16C814A3AA41DFEEC2796" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4B6044D186B16C814A3AA41DFEEC2796" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_9D4E1160645BA9528B31A41DFEED8F1D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_9D4E1160645BA9528B31A41DFEED8F1D" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ComputerEquipmentAndSoftwareMember" xlink:label="loc_pcrx_ComputerEquipmentAndSoftwareMember_2AD482D44F24DEB658A8A41DFEEEC267" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:to="loc_pcrx_ComputerEquipmentAndSoftwareMember_2AD482D44F24DEB658A8A41DFEEEC267" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_C91F5433D42EDC251EA0A41DFEEEF013" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_C91F5433D42EDC251EA0A41DFEEEF013" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_9DC43D551604404A4225A41DFEEEA2A6" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_9DC43D551604404A4225A41DFEEEA2A6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_A2D90375FAD2DB1DA6A3A41DFEEFB163" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_F86A119C2CD82E9D1C3BA41DFEEDFBD4" xlink:to="loc_us-gaap_ConstructionInProgressMember_A2D90375FAD2DB1DA6A3A41DFEEFB163" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_70B49856A9C17A4FE971A41DFEF01C2E" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_A3295FA97E026CCE741DA41DFEEC643B" xlink:to="loc_us-gaap_ProductOrServiceAxis_70B49856A9C17A4FE971A41DFEF01C2E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_1A574BB4F22B2B202721A41DFEF09423" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_70B49856A9C17A4FE971A41DFEF01C2E" xlink:to="loc_us-gaap_ProductsAndServicesDomain_1A574BB4F22B2B202721A41DFEF09423" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_A3295FA97E026CCE741DA41DFEEC643B" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_C20B091EF8C989A2D6E9A41DFEF10092" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_C20B091EF8C989A2D6E9A41DFEF10092" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_F702530ECDA7A7454B8AA41DFEF1BBAC" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_F702530ECDA7A7454B8AA41DFEF1BBAC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_F38DFCD502CDC19BCDE8A41DFEF21731" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_F38DFCD502CDC19BCDE8A41DFEF21731" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_90411F447F32CA378029A41DFEF2DA0D" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:to="loc_us-gaap_Depreciation_90411F447F32CA378029A41DFEF2DA0D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InterestCostsCapitalized" xlink:label="loc_us-gaap_InterestCostsCapitalized_8EA65ECA398878FF556CA41DFEF3B69D" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_29B91E5301ED0893CD50A41DFEF11104" xlink:to="loc_us-gaap_InterestCostsCapitalized_8EA65ECA398878FF556CA41DFEF3B69D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/FixedAssetsTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_98A8A15E16B75F78A80D6F31F6F3C325" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" xlink:label="loc_pcrx_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock_B61FAF959633EA23CE156F31F6F47EA3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_98A8A15E16B75F78A80D6F31F6F3C325" xlink:to="loc_pcrx_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock_B61FAF959633EA23CE156F31F6F47EA3" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/GoodwillAndIntangibleAssets" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_AF4D5A5F3BE71D5B85D36F31F5A4D3D2" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IntangibleAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_IntangibleAssetsDisclosureTextBlock_EFEA7507DC08CB12DF086F31F5A44369" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_AF4D5A5F3BE71D5B85D36F31F5A4D3D2" xlink:to="loc_us-gaap_IntangibleAssetsDisclosureTextBlock_EFEA7507DC08CB12DF086F31F5A44369" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/GoodwillAndIntangibleAssetsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4905CC1F5B9E5CA09B286D276DF3CD68" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfGoodwillTable" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_D7F24A2F805F9BF641B86D276DF393B5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4905CC1F5B9E5CA09B286D276DF3CD68" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_D7F24A2F805F9BF641B86D276DF393B5" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis" xlink:label="loc_pcrx_MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis_C6EF164446828DCEB3F86D276DF3FE8B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_D7F24A2F805F9BF641B86D276DF393B5" xlink:to="loc_pcrx_MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis_C6EF164446828DCEB3F86D276DF3FE8B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain" xlink:label="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis_C6EF164446828DCEB3F86D276DF3FE8B" xlink:to="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_UponFirstCommercialSaleInUnitedStatesMember" xlink:label="loc_pcrx_UponFirstCommercialSaleInUnitedStatesMember_4DDBC49FB681B9B53E356D276DF3E28A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:to="loc_pcrx_UponFirstCommercialSaleInUnitedStatesMember_4DDBC49FB681B9B53E356D276DF3E28A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_UponFirstCommercialSaleInMajorEUCountryMember" xlink:label="loc_pcrx_UponFirstCommercialSaleInMajorEUCountryMember_9B316A1080C60FE2FAC56D276DF393FB" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:to="loc_pcrx_UponFirstCommercialSaleInMajorEUCountryMember_9B316A1080C60FE2FAC56D276DF393FB" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_UponAnnualNetSalesReachingDollar100.0MillionThresholdMember" xlink:label="loc_pcrx_UponAnnualNetSalesReachingDollar100.0MillionThresholdMember_46A558D318F7D84E446B6D276DF3F923" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:to="loc_pcrx_UponAnnualNetSalesReachingDollar100.0MillionThresholdMember_46A558D318F7D84E446B6D276DF3F923" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_UponAnnualNetSalesReachingDollar250.0MillionThresholdMember" xlink:label="loc_pcrx_UponAnnualNetSalesReachingDollar250.0MillionThresholdMember_97660386F9CB76575A456D276DF35977" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:to="loc_pcrx_UponAnnualNetSalesReachingDollar250.0MillionThresholdMember_97660386F9CB76575A456D276DF35977" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember" xlink:label="loc_pcrx_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember_FA6BB90DD09335FB076B6D276DF3E47A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_StageAtWhichMilestonePaymentsForProductArePayableInConnectionWithAcquisitionDomain_D2F8A5F2DDFF7E3B9C406D276DF35208" xlink:to="loc_pcrx_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember_FA6BB90DD09335FB076B6D276DF3E47A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillLineItems" xlink:label="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_D7F24A2F805F9BF641B86D276DF393B5" xlink:to="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_GoodwillRecordedonMilestonePayments" xlink:label="loc_pcrx_GoodwillRecordedonMilestonePayments_923C65BB82B3D7862B7E6D2CAD046106" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_GoodwillRecordedonMilestonePayments_923C65BB82B3D7862B7E6D2CAD046106" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PaymentObligationArisingDuetoNetSalesCollectedThresholdof100Million" xlink:label="loc_pcrx_PaymentObligationArisingDuetoNetSalesCollectedThresholdof100Million_C7C3F09C60339A30CEBC6D2784E8FCEF" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_PaymentObligationArisingDuetoNetSalesCollectedThresholdof100Million_C7C3F09C60339A30CEBC6D2784E8FCEF" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition" xlink:label="loc_pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition_714E9A9F72DF03C201A96D276DF364D9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition_714E9A9F72DF03C201A96D276DF364D9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition" xlink:label="loc_pcrx_AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition_03F9B8764D927F211D3E6D276DF301C2" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition_03F9B8764D927F211D3E6D276DF301C2" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PaymentObligationArisingDueToFirstCommercialSaleOfProductInConnectionWithAcquisition" xlink:label="loc_pcrx_PaymentObligationArisingDueToFirstCommercialSaleOfProductInConnectionWithAcquisition_AC291E56C84EA57A4ECA6D276DF329C0" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_PaymentObligationArisingDueToFirstCommercialSaleOfProductInConnectionWithAcquisition_AC291E56C84EA57A4ECA6D276DF329C0" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ContingentPaymentObligationEstablishedForSaleOfProductInConnectionWithAcquisition" xlink:label="loc_pcrx_ContingentPaymentObligationEstablishedForSaleOfProductInConnectionWithAcquisition_32FCB31643BA14A174FE6D276DF3D28A" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_ContingentPaymentObligationEstablishedForSaleOfProductInConnectionWithAcquisition_32FCB31643BA14A174FE6D276DF3D28A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_32CC3BA5EE6ED15342206D276DF3F8BF" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_us-gaap_Goodwill_32CC3BA5EE6ED15342206D276DF3F8BF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillRollForward" xlink:label="loc_us-gaap_GoodwillRollForward_4FB5274575739F7DE8476D276DF32D2D" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_us-gaap_GoodwillRollForward_4FB5274575739F7DE8476D276DF32D2D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_6E2563BDED89BD95B3F96D276DF347F9" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_4FB5274575739F7DE8476D276DF32D2D" xlink:to="loc_us-gaap_Goodwill_6E2563BDED89BD95B3F96D276DF347F9" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_GoodwillRecordedforEarnOutPayments" xlink:label="loc_pcrx_GoodwillRecordedforEarnOutPayments_DA2615B5F3EB9B136EBC6D276DF385AF" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_4FB5274575739F7DE8476D276DF32D2D" xlink:to="loc_pcrx_GoodwillRecordedforEarnOutPayments_DA2615B5F3EB9B136EBC6D276DF385AF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_ADD9DBD683414195A32A6D276DF37348" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_4FB5274575739F7DE8476D276DF32D2D" xlink:to="loc_us-gaap_Goodwill_ADD9DBD683414195A32A6D276DF37348" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NetSalesCollectedThresholdWhichTriggersaPaymentObligation" xlink:label="loc_pcrx_NetSalesCollectedThresholdWhichTriggersaPaymentObligation_DF149121275050E2CF6D6D2801E5B2AC" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_NetSalesCollectedThresholdWhichTriggersaPaymentObligation_DF149121275050E2CF6D6D2801E5B2AC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TotalGoodwillRecordedforEarnOutPayments" xlink:label="loc_pcrx_TotalGoodwillRecordedforEarnOutPayments_25023AF3B52D175B451C6D287CC820FF" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_98529F72718BE5FD41CF6D276DF30BCA" xlink:to="loc_pcrx_TotalGoodwillRecordedforEarnOutPayments_25023AF3B52D175B451C6D287CC820FF" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/GoodwillAndIntangibleAssetsDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_573838C9A3FD68162C19A41DFE91711E" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_BECC644FB4E23BBC555EA41DFE928FB0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_573838C9A3FD68162C19A41DFE91711E" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_BECC644FB4E23BBC555EA41DFE928FB0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CF2BDE08FEDA90CEADC2A41DFE926A69" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_BECC644FB4E23BBC555EA41DFE928FB0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CF2BDE08FEDA90CEADC2A41DFE926A69" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6C66422C09697052623FA41DFE93D62E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_CF2BDE08FEDA90CEADC2A41DFE926A69" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6C66422C09697052623FA41DFE93D62E" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CoreTechnologyMember" xlink:label="loc_pcrx_CoreTechnologyMember_90F16BE9E00765B8B821A41DFE933102" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6C66422C09697052623FA41DFE93D62E" xlink:to="loc_pcrx_CoreTechnologyMember_90F16BE9E00765B8B821A41DFE933102" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_53B52F96075192D18C1EA41DFE93A7F4" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6C66422C09697052623FA41DFE93D62E" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_53B52F96075192D18C1EA41DFE93A7F4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TrademarksAndTradeNamesMember" xlink:label="loc_us-gaap_TrademarksAndTradeNamesMember_4FDB57E6CCEA1415BB62A41DFE948726" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6C66422C09697052623FA41DFE93D62E" xlink:to="loc_us-gaap_TrademarksAndTradeNamesMember_4FDB57E6CCEA1415BB62A41DFE948726" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_BECC644FB4E23BBC555EA41DFE928FB0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_2B04EB04D6BCE537D86DA41DFE961656" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_2B04EB04D6BCE537D86DA41DFE961656" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_9133B6D3C9CD88F99E04A41DFE96272C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_9133B6D3C9CD88F99E04A41DFE96272C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_E3D963AD9F109095973EA41DFE968FE8" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_E3D963AD9F109095973EA41DFE968FE8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_A622A589B307AACB811AA41DFE96C785" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_A622A589B307AACB811AA41DFE96C785" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_655C1D30C04599AA3E72A41DFE97D04F" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_655C1D30C04599AA3E72A41DFE97D04F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_132003759B0C65A3458FA41DFE972777" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_132003759B0C65A3458FA41DFE972777" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_DB2C985050732C39F7C4A41DFE980A46" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_E9FBE6B0E723654845C8A41DFE95AD86" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_DB2C985050732C39F7C4A41DFE980A46" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_BAADB6DCAAB00A9BF96AA41DFE9842B3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_DB2C985050732C39F7C4A41DFE980A46" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_BAADB6DCAAB00A9BF96AA41DFE9842B3" xlink:type="arc"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_DB2C985050732C39F7C4A41DFE980A46" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_A622A589B307AACB811AA41DFE96C785" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/GoodwillAndIntangibleAssetsTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_BC2C5222BA1CD9CBD4C46F31F5F05BF2" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock" xlink:label="loc_us-gaap_ScheduleOfGoodwillTextBlock_0351E6990F024F823BAD6F31F5F09A23" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_BC2C5222BA1CD9CBD4C46F31F5F05BF2" xlink:to="loc_us-gaap_ScheduleOfGoodwillTextBlock_0351E6990F024F823BAD6F31F5F09A23" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_EBEB315A372F39DC275E6F31F5F01B3A" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_BC2C5222BA1CD9CBD4C46F31F5F05BF2" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_EBEB315A372F39DC275E6F31F5F01B3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_8809D17654310127A9E56F31F5F1D2FE" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_BC2C5222BA1CD9CBD4C46F31F5F05BF2" xlink:to="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_8809D17654310127A9E56F31F5F1D2FE" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/IncomeTaxes" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_6CFAF6935967FCE878316F31F711AB81" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_91B867654C9FF76858466F31F71116E1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_6CFAF6935967FCE878316F31F711AB81" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_91B867654C9FF76858466F31F71116E1" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/IncomeTaxesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_B95B9FF660D9E47E0EB3A9164C633D2C" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_IncomeTaxProvisionTable" xlink:label="loc_pcrx_IncomeTaxProvisionTable_919797651ADD64BDD040A9164C63FD28" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_B95B9FF660D9E47E0EB3A9164C633D2C" xlink:to="loc_pcrx_IncomeTaxProvisionTable_919797651ADD64BDD040A9164C63FD28" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_78531C17839B058AC46EA9164C6318F8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionTable_919797651ADD64BDD040A9164C63FD28" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_78531C17839B058AC46EA9164C6318F8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_752E88EE80FA1FECA5ADA9164C63DE33" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_78531C17839B058AC46EA9164C6318F8" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_752E88EE80FA1FECA5ADA9164C63DE33" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchMember" xlink:label="loc_us-gaap_ResearchMember_59CC1175F12296C7571BA9164C637D44" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_752E88EE80FA1FECA5ADA9164C63DE33" xlink:to="loc_us-gaap_ResearchMember_59CC1175F12296C7571BA9164C637D44" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_4D2487D43D701F3C5DD2A9164C638F0E" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionTable_919797651ADD64BDD040A9164C63FD28" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_4D2487D43D701F3C5DD2A9164C638F0E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_3662675D767757E898D6A9164C635F7A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_4D2487D43D701F3C5DD2A9164C638F0E" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_3662675D767757E898D6A9164C635F7A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_CDF6E5BB77738C247B0BA9164C6331AA" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_3662675D767757E898D6A9164C635F7A" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_CDF6E5BB77738C247B0BA9164C6331AA" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_IncomeTaxProvisionLineItems" xlink:label="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionTable_919797651ADD64BDD040A9164C63FD28" xlink:to="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NetOperatingLossSubjecttoLimitation" xlink:label="loc_pcrx_NetOperatingLossSubjecttoLimitation_9CCB62951E0FDBE54120A9164C634FE1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_NetOperatingLossSubjecttoLimitation_9CCB62951E0FDBE54120A9164C634FE1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_33A89DA814D4318F3DB2A9164C63FFCE" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_33A89DA814D4318F3DB2A9164C63FFCE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_IncomeTaxProvision" xlink:label="loc_pcrx_IncomeTaxProvision_914D6A7251392A7E2AE9A9164C63DC7A" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_IncomeTaxProvision_914D6A7251392A7E2AE9A9164C63DC7A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_NonUSNetOperatingLoss" xlink:label="loc_pcrx_NonUSNetOperatingLoss_955A6732D58289131BEFA9164C731CE7" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_NonUSNetOperatingLoss_955A6732D58289131BEFA9164C731CE7" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax" xlink:label="loc_pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax_4B10BDBD593278DEC9C9A9164C734BAC" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax_4B10BDBD593278DEC9C9A9164C734BAC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AvailableNetOperatingLossSubjecttoLimitation" xlink:label="loc_pcrx_AvailableNetOperatingLossSubjecttoLimitation_347558366AD4B7494A1AA9164C735CCA" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_AvailableNetOperatingLossSubjecttoLimitation_347558366AD4B7494A1AA9164C735CCA" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_FutureNOLsWhichWillBecomeAvailable" xlink:label="loc_pcrx_FutureNOLsWhichWillBecomeAvailable_F8D7623962D024C45D01A9164C735420" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_FutureNOLsWhichWillBecomeAvailable_F8D7623962D024C45D01A9164C735420" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_FutureNOLsWhichWillBecomeAvailable2017" xlink:label="loc_pcrx_FutureNOLsWhichWillBecomeAvailable2017_C626871485A1CDC5FADBA9164C733518" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_FutureNOLsWhichWillBecomeAvailable2017_C626871485A1CDC5FADBA9164C733518" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_FutureNOLsWhichWillBecomeAvailable20182022" xlink:label="loc_pcrx_FutureNOLsWhichWillBecomeAvailable20182022_4F518FB17D04FC2CB60BA9164C737452" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_FutureNOLsWhichWillBecomeAvailable20182022_4F518FB17D04FC2CB60BA9164C737452" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_FutureNOLsWhichWillBecomeAvailable2015Onward" xlink:label="loc_pcrx_FutureNOLsWhichWillBecomeAvailable2015Onward_828A049A9E166770A225A9164C739B52" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_IncomeTaxProvisionLineItems_9E95198F003C6B4D78D2A9164C63A999" xlink:to="loc_pcrx_FutureNOLsWhichWillBecomeAvailable2015Onward_828A049A9E166770A225A9164C739B52" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_B95B9FF660D9E47E0EB3A9164C633D2C" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_4CC131BCF9EA8E343930A9164C73A71B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_4CC131BCF9EA8E343930A9164C73A71B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_295EE5E34407F0AAE169A9164C739C9E" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_295EE5E34407F0AAE169A9164C739C9E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_C57CBF432C77729FB7E9A9164C7384F6" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_C57CBF432C77729FB7E9A9164C7384F6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_E6201B4CD2E2E5E792AFA9164C73660F" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_E6201B4CD2E2E5E792AFA9164C73660F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EffectiveIncomeTaxRateReconciliationInterestExpensePercent" xlink:label="loc_pcrx_EffectiveIncomeTaxRateReconciliationInterestExpensePercent_02FF59AEDFD38F2B4F97A9164C7353D1" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_pcrx_EffectiveIncomeTaxRateReconciliationInterestExpensePercent_02FF59AEDFD38F2B4F97A9164C7353D1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_99485C09EF23018185E3A9164C730337" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_99485C09EF23018185E3A9164C730337" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_A68428250010D0A57D39A9164C73B7B3" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_DB4B4D194836FD311292A9164C73E212" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_A68428250010D0A57D39A9164C73B7B3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_727F36AB540C302BF0F1A9164C735B23" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_B95B9FF660D9E47E0EB3A9164C633D2C" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_727F36AB540C302BF0F1A9164C735B23" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_727F36AB540C302BF0F1A9164C735B23" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_BC50D210D9C9E3AD3212A9164C73852E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_BC50D210D9C9E3AD3212A9164C73852E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_0F0CB9A31D793D280DCBA9164C73EC66" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_0F0CB9A31D793D280DCBA9164C73EC66" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_F040CE9C16B1693651CFA9164C732977" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_F040CE9C16B1693651CFA9164C732977" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_E2E72EE9C2256428CABFA9164C737F8C" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_E2E72EE9C2256428CABFA9164C737F8C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_16DE4E6984010045ACF2A9164C73EDB8" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_16DE4E6984010045ACF2A9164C73EDB8" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DeferredTaxAssetsStockBasedCompensation" xlink:label="loc_pcrx_DeferredTaxAssetsStockBasedCompensation_E25AC6B034C1087DB521A9164C7346AB" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_pcrx_DeferredTaxAssetsStockBasedCompensation_E25AC6B034C1087DB521A9164C7346AB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_9D1C2873D7C2970CD685A9164C7393FF" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_9D1C2873D7C2970CD685A9164C7393FF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_06EE6C17206952FE9B0DA9164C736D29" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_06EE6C17206952FE9B0DA9164C736D29" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_61182F5E3E49B448BFE2A9164C7397D7" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_61182F5E3E49B448BFE2A9164C7397D7" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DeferredTaxAssetsGrossNetofDeferredTaxLiabilitiesBeforeValuationAllowance" xlink:label="loc_pcrx_DeferredTaxAssetsGrossNetofDeferredTaxLiabilitiesBeforeValuationAllowance_9646E7F9E9F2FEE5F47EA9164C736F32" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_pcrx_DeferredTaxAssetsGrossNetofDeferredTaxLiabilitiesBeforeValuationAllowance_9646E7F9E9F2FEE5F47EA9164C736F32" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_28B0BC7BB4C63071C398A9164C738906" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_28B0BC7BB4C63071C398A9164C738906" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_8A836AEF06E15DBE026BA9164C73EABA" xlink:type="locator"/>
<presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_FC1B8EC06295E04956DCA9164C738FFC" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_8A836AEF06E15DBE026BA9164C73EABA" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/IncomeTaxesDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_DA4F4BB0387BE9F44EE8A916828165A0" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_80BBE73F3A43E3C59CC2A9168281B685" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_DA4F4BB0387BE9F44EE8A916828165A0" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_80BBE73F3A43E3C59CC2A9168281B685" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_B5C28FE83CAF28E8A23BA9168281E817" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_80BBE73F3A43E3C59CC2A9168281B685" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_B5C28FE83CAF28E8A23BA9168281E817" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_24EF9917D8BE781DE85DA91682817F97" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_B5C28FE83CAF28E8A23BA9168281E817" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_24EF9917D8BE781DE85DA91682817F97" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_F7FB1B9F8EA149410D6EA916828131D7" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_24EF9917D8BE781DE85DA91682817F97" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_F7FB1B9F8EA149410D6EA916828131D7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_74C697973E9B696122DCA9168281E227" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_24EF9917D8BE781DE85DA91682817F97" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_74C697973E9B696122DCA9168281E227" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_A15F035D859421E07965A91682817797" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_80BBE73F3A43E3C59CC2A9168281B685" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_A15F035D859421E07965A91682817797" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_2F84153E505D4675CCC9A9168281EC75" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_A15F035D859421E07965A91682817797" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_2F84153E505D4675CCC9A9168281EC75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchMember" xlink:label="loc_us-gaap_ResearchMember_9B7BD6B4D27B3353F5EAA9168281BEB1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_2F84153E505D4675CCC9A9168281EC75" xlink:to="loc_us-gaap_ResearchMember_9B7BD6B4D27B3353F5EAA9168281BEB1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_80BBE73F3A43E3C59CC2A9168281B685" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses" xlink:label="loc_pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses_5933B58D447BB89B2B5BA91682817796" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses_5933B58D447BB89B2B5BA91682817796" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_F012098A8BB4104D82D4A91682811D16" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_us-gaap_OperatingLossCarryforwards_F012098A8BB4104D82D4A91682811D16" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_FB31FF388349D065B428A91682819D08" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_FB31FF388349D065B428A91682819D08" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_B7D883FF8E96F3C377E8A916828159C6" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_B7D883FF8E96F3C377E8A916828159C6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_4F0AD16D3BD26F7D7A24A9168281922A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_4F0AD16D3BD26F7D7A24A9168281922A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax" xlink:label="loc_pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax_416EE9F4621D8C61A203A91682814998" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax_416EE9F4621D8C61A203A91682814998" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_OperatingLossCarryforwardsRelatedToStockBasedCompensation" xlink:label="loc_pcrx_OperatingLossCarryforwardsRelatedToStockBasedCompensation_413E2A3993A500819C3CA916828157A9" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_pcrx_OperatingLossCarryforwardsRelatedToStockBasedCompensation_413E2A3993A500819C3CA916828157A9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_1E9E499A0EEE97EE28A7A9168281B509" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D19C4393868E2531F4F6A91682818A41" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_1E9E499A0EEE97EE28A7A9168281B509" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:label="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_5D0E56DE9E28A164EC68A91682814640" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_DA4F4BB0387BE9F44EE8A916828165A0" xlink:to="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_5D0E56DE9E28A164EC68A91682814640" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/IncomeTaxesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_5775F43F418034AADAB2A41DFC4B620C" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_873C0CF68E3C633ECD85A41DFC4C86E8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5775F43F418034AADAB2A41DFC4B620C" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_873C0CF68E3C633ECD85A41DFC4C86E8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_7807383FA4F0F243CDEAA41DFC4CA7F5" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5775F43F418034AADAB2A41DFC4B620C" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_7807383FA4F0F243CDEAA41DFC4CA7F5" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/Inventories" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_DA44662F761D2CF7F3656F31F4E7605B" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_EA4822C3E4230AF9A74D6F31F4E79AD0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_DA44662F761D2CF7F3656F31F4E7605B" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_EA4822C3E4230AF9A74D6F31F4E79AD0" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/InventoriesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_24290BD10BCECCEEBA536F31F60C389C" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_DB179018D87032D7FABE6F31F60D7EF1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_24290BD10BCECCEEBA536F31F60C389C" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_DB179018D87032D7FABE6F31F60D7EF1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_B80A75171FC452BD305B6F31F60D6007" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_24290BD10BCECCEEBA536F31F60C389C" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_B80A75171FC452BD305B6F31F60D6007" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_FE70D16DB7CBACCB3B8C6F31F60DDE3B" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_24290BD10BCECCEEBA536F31F60C389C" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_FE70D16DB7CBACCB3B8C6F31F60DDE3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_2F58A624C50CAAA0A0956F31F60D944D" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_24290BD10BCECCEEBA536F31F60C389C" xlink:to="loc_us-gaap_InventoryNet_2F58A624C50CAAA0A0956F31F60D944D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/InventoriesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_7D09C6ABAEA1851D9A2F6F31F5A294CB" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_4DE946A85B4EF12A27CB6F31F5A28886" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_7D09C6ABAEA1851D9A2F6F31F5A294CB" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_4DE946A85B4EF12A27CB6F31F5A28886" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/NetIncomeLossPerShare" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_E0DB5EB444C4F00C098BA41DFC9E7BDB" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_6FF5E0A52E20ACA993E7A41DFC9FB8DF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_E0DB5EB444C4F00C098BA41DFC9E7BDB" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_6FF5E0A52E20ACA993E7A41DFC9FB8DF" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/NetIncomeLossPerShareDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_8055FFEC69823046E633A41DFC8CAD30" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_87B2395B49AF57D2961FA41DFC8CCF87" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8055FFEC69823046E633A41DFC8CAD30" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_87B2395B49AF57D2961FA41DFC8CCF87" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_B4F0284B735A485F13A2A41DFC8C125A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_87B2395B49AF57D2961FA41DFC8CCF87" xlink:to="loc_us-gaap_NetIncomeLoss_B4F0284B735A485F13A2A41DFC8C125A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3C35160A61E1629BACC1A41DFC8D62B9" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8055FFEC69823046E633A41DFC8CAD30" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3C35160A61E1629BACC1A41DFC8D62B9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_437726387029B11CFDB1A41DFC8D8E2E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3C35160A61E1629BACC1A41DFC8D62B9" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_437726387029B11CFDB1A41DFC8D8E2E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_66B82B2719F6329F3DE9A41DFC8E199F" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8055FFEC69823046E633A41DFC8CAD30" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_66B82B2719F6329F3DE9A41DFC8E199F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_C252713F82C171A167B0A41DFC8E33E8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_66B82B2719F6329F3DE9A41DFC8E199F" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_C252713F82C171A167B0A41DFC8E33E8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_F65768EB279A2B828F52A41DFC8E446C" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8055FFEC69823046E633A41DFC8CAD30" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_F65768EB279A2B828F52A41DFC8E446C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_52622E66F171CA2C5C79A41DFC8EC8FB" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_F65768EB279A2B828F52A41DFC8E446C" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_52622E66F171CA2C5C79A41DFC8EC8FB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_682B54E9831BDFC37483A41DFC8E7B02" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_52622E66F171CA2C5C79A41DFC8EC8FB" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_682B54E9831BDFC37483A41DFC8E7B02" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_86AEFE191ECBF08B04B7A41DFC8FA2CE" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_F65768EB279A2B828F52A41DFC8E446C" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_86AEFE191ECBF08B04B7A41DFC8FA2CE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AntidilutiveSecuritiesExcludedfromComputationofEarningsperShareAmountTreasuryStockMethod" xlink:label="loc_pcrx_AntidilutiveSecuritiesExcludedfromComputationofEarningsperShareAmountTreasuryStockMethod_E1C3B271A36F5D4C9080A41DFC8F9D66" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_86AEFE191ECBF08B04B7A41DFC8FA2CE" xlink:to="loc_pcrx_AntidilutiveSecuritiesExcludedfromComputationofEarningsperShareAmountTreasuryStockMethod_E1C3B271A36F5D4C9080A41DFC8F9D66" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/NetIncomeLossPerShareDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_7B7CA77A962F08C687FCA41DFC78C4C9" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_AF0A19C83C607393F1A1A41DFC798552" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7B7CA77A962F08C687FCA41DFC78C4C9" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_AF0A19C83C607393F1A1A41DFC798552" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_D7D4D2D83261BE90C81FA41DFC795F16" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_AF0A19C83C607393F1A1A41DFC798552" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_D7D4D2D83261BE90C81FA41DFC795F16" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_D7D4D2D83261BE90C81FA41DFC795F16" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_9A2C14A37377BA741352A41DFC7A8F04" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:to="loc_us-gaap_EmployeeStockOptionMember_9A2C14A37377BA741352A41DFC7A8F04" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_9FEA5087996656A1C086A41DFC7A7B6A" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_9FEA5087996656A1C086A41DFC7A7B6A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_5984545BE326FB3F0372A41DFC7AD3DB" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:to="loc_us-gaap_WarrantMember_5984545BE326FB3F0372A41DFC7AD3DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeStockMember" xlink:label="loc_us-gaap_EmployeeStockMember_0066B458BD84FC57097AA41DFC7AE9E3" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A2364ED7766EA36CA726A41DFC799FF1" xlink:to="loc_us-gaap_EmployeeStockMember_0066B458BD84FC57097AA41DFC7AE9E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90E6BD78906971339607A41DFC7BD036" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_AF0A19C83C607393F1A1A41DFC798552" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90E6BD78906971339607A41DFC7BD036" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_FB68B6466AD8D556B658A41DFC7B7184" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90E6BD78906971339607A41DFC7BD036" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_FB68B6466AD8D556B658A41DFC7B7184" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/NetIncomeLossPerShareTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_E92AD8AF3D0AEBC3F18DA41DFC9672AC" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_2DD1BBCFEEDD5D7A6726A41DFC967738" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_E92AD8AF3D0AEBC3F18DA41DFC9672AC" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_2DD1BBCFEEDD5D7A6726A41DFC967738" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_5F08E468E30488414EC9A41DFC97CE10" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_E92AD8AF3D0AEBC3F18DA41DFC9672AC" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_5F08E468E30488414EC9A41DFC97CE10" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/OtherEmployeeBenefits" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_9A4DDAC41FCC280F8E746F31F7174F8A" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CompensationAndEmployeeBenefitPlansTextBlock" xlink:label="loc_us-gaap_CompensationAndEmployeeBenefitPlansTextBlock_BFAD719342E6F02A42706F31F717AD4D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_9A4DDAC41FCC280F8E746F31F7174F8A" xlink:to="loc_us-gaap_CompensationAndEmployeeBenefitPlansTextBlock_BFAD719342E6F02A42706F31F717AD4D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/OtherEmployeeBenefitsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_E2946D96302948A55BAC6F31F5EA6A75" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DefinedContributionPensionAndOtherPostretirementPlansDisclosureAbstract" xlink:label="loc_us-gaap_DefinedContributionPensionAndOtherPostretirementPlansDisclosureAbstract_0F8CB96646E6EBBD10BF6F31F5EAA91E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_E2946D96302948A55BAC6F31F5EA6A75" xlink:to="loc_us-gaap_DefinedContributionPensionAndOtherPostretirementPlansDisclosureAbstract_0F8CB96646E6EBBD10BF6F31F5EAA91E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_C739E60C41A4F5C055736F31F5EAD17D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedContributionPensionAndOtherPostretirementPlansDisclosureAbstract_0F8CB96646E6EBBD10BF6F31F5EAA91E" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_C739E60C41A4F5C055736F31F5EAD17D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/RecentAccountingPronouncements" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_88D696B5DFA814301DEB6F31F4AE0AAE" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DescriptionOfNewAccountingPronouncementsNotYetAdopted" xlink:label="loc_us-gaap_DescriptionOfNewAccountingPronouncementsNotYetAdopted_E55EB4FCB1389B77B95B6F31F4AF8FDF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_88D696B5DFA814301DEB6F31F4AE0AAE" xlink:to="loc_us-gaap_DescriptionOfNewAccountingPronouncementsNotYetAdopted_E55EB4FCB1389B77B95B6F31F4AF8FDF" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/RelatedPartyTransactions" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_04AC136C7EC6E962B26E6F31F4C2C165" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_396832128558884C2B2A6F31F4C26272" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_04AC136C7EC6E962B26E6F31F4C2C165" xlink:to="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_396832128558884C2B2A6F31F4C26272" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/RelatedPartyTransactionsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_8AD4FFE84698502EA959A41DFAC78FD4" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_8AD4FFE84698502EA959A41DFAC78FD4" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3A6EC86FB09FFEF75406A41DFAC8507D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3A6EC86FB09FFEF75406A41DFAC8507D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_15B48785E4A3FCA72E40A41DFAC9BB07" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3A6EC86FB09FFEF75406A41DFAC8507D" xlink:to="loc_us-gaap_RelatedPartyDomain_15B48785E4A3FCA72E40A41DFAC9BB07" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MPMAssetManagementMember" xlink:label="loc_pcrx_MPMAssetManagementMember_447193E9F6B93A5FBA43A41DFAC956D3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_15B48785E4A3FCA72E40A41DFAC9BB07" xlink:to="loc_pcrx_MPMAssetManagementMember_447193E9F6B93A5FBA43A41DFAC956D3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_38316FB9ECE9ECC89DA0A41DFAC92508" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_15B48785E4A3FCA72E40A41DFAC9BB07" xlink:to="loc_us-gaap_DirectorMember_38316FB9ECE9ECC89DA0A41DFAC92508" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EnergyAxis" xlink:label="loc_us-gaap_EnergyAxis_040D7A2F259B5F5A0414A41DFAC9F419" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:to="loc_us-gaap_EnergyAxis_040D7A2F259B5F5A0414A41DFAC9F419" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EnergyDomain" xlink:label="loc_us-gaap_EnergyDomain_AB80A98FE35DA2AFFB50A41DFACACE74" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EnergyAxis_040D7A2F259B5F5A0414A41DFAC9F419" xlink:to="loc_us-gaap_EnergyDomain_AB80A98FE35DA2AFFB50A41DFACACE74" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConsultingAgreementMember" xlink:label="loc_pcrx_ConsultingAgreementMember_E9CFD4907D5947EBFB48A41DFACAD377" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EnergyDomain_AB80A98FE35DA2AFFB50A41DFACACE74" xlink:to="loc_pcrx_ConsultingAgreementMember_E9CFD4907D5947EBFB48A41DFACAD377" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_642C6D6AD016E223D23AA41DFACA0F08" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:to="loc_us-gaap_RangeAxis_642C6D6AD016E223D23AA41DFACA0F08" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_E782E0C61D06CE58BD5BA41DFACB8DA5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_642C6D6AD016E223D23AA41DFACA0F08" xlink:to="loc_us-gaap_RangeMember_E782E0C61D06CE58BD5BA41DFACB8DA5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_9A410D2B1DDE632A87B5A41DFACB22A8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_E782E0C61D06CE58BD5BA41DFACB8DA5" xlink:to="loc_us-gaap_MinimumMember_9A410D2B1DDE632A87B5A41DFACB22A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_CA937E9805D9294EC4BEA41DFACB4038" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_E782E0C61D06CE58BD5BA41DFACB8DA5" xlink:to="loc_us-gaap_MaximumMember_CA937E9805D9294EC4BEA41DFACB4038" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_C137A3951613DAFD6EEFA41DFAC81230" xlink:to="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RelatedPartyTransactionMonthlyAmountDuetoRelatedParty" xlink:label="loc_pcrx_RelatedPartyTransactionMonthlyAmountDuetoRelatedParty_38DEA3CB4346C7A2B627A41DFACBC199" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_pcrx_RelatedPartyTransactionMonthlyAmountDuetoRelatedParty_38DEA3CB4346C7A2B627A41DFACBC199" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth" xlink:label="loc_pcrx_RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth_09C2C5787A9EE09BE4AAA41DFACC4A7C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_pcrx_RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth_09C2C5787A9EE09BE4AAA41DFACC4A7C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:label="loc_us-gaap_RelatedPartyTransactionAmountsOfTransaction_2CF786BFEB4142FA93E9A41DFACD8D91" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_us-gaap_RelatedPartyTransactionAmountsOfTransaction_2CF786BFEB4142FA93E9A41DFACD8D91" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DueToRelatedPartiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_DueToRelatedPartiesCurrentAndNoncurrent_F4D82BE28D5563C4F46CA41DFACD7B5C" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_us-gaap_DueToRelatedPartiesCurrentAndNoncurrent_F4D82BE28D5563C4F46CA41DFACD7B5C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" xlink:label="loc_pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares_EBB321A6B131E92A0E60A41DFACE187A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares_EBB321A6B131E92A0E60A41DFACE187A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" xlink:label="loc_pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice_D94ABA9AABEA701F2B00A41DFACE9545" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_CF3959AC94585C0A0AD9A41DFACBA490" xlink:to="loc_pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice_D94ABA9AABEA701F2B00A41DFACE9545" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnaudited" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_89003943B8168C8145F26F31F6F111DF" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_738E3C1B7B83A571CE416F31F6F13E67" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_89003943B8168C8145F26F31F6F111DF" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_738E3C1B7B83A571CE416F31F6F13E67" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnauditedDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_08706B7A895430B0497FA2C04067BEB4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_Revenues_08706B7A895430B0497FA2C04067BEB4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaap_CostOfRevenue_1AE18C95AAC60A890089A2C0406781BB" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_CostOfRevenue_1AE18C95AAC60A890089A2C0406781BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_0B09625335CC1CA12C21A2C040675DF9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_OperatingExpenses_0B09625335CC1CA12C21A2C040675DF9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_BF2F2D75CEB6B1164AC1A2C040687492" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_NetIncomeLoss_BF2F2D75CEB6B1164AC1A2C040687492" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_71B8B5BDA8A9DB5E65D2A2C040685235" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_EarningsPerShareBasic_71B8B5BDA8A9DB5E65D2A2C040685235" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_D3F93A5FFE50D2CBB695A2C040684681" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5856A38584BC6DEECAAFA2C04067D318" xlink:to="loc_us-gaap_EarningsPerShareDiluted_D3F93A5FFE50D2CBB695A2C040684681" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SelectedQuarterlyFinancialDataUnauditedTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_0123900D5295022917D16F31F59C508D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_FEC4C6C79A6D64DE36146F31F59DED9F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_0123900D5295022917D16F31F59C508D" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_FEC4C6C79A6D64DE36146F31F59DED9F" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockPlans" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9A6BDDABDF51814666DA6F31F49ACF2B" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_43752B2BF467EC913DC66F31F49B8494" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9A6BDDABDF51814666DA6F31F49ACF2B" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_43752B2BF467EC913DC66F31F49B8494" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockPlansDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_534DD5A2DAF61F799E5A1470D2CD4B26" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_617BDE703D3323C7565F1470D2CD354B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_534DD5A2DAF61F799E5A1470D2CD4B26" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_617BDE703D3323C7565F1470D2CD354B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_CB181974AF965F81A2311470D2CDE12F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_617BDE703D3323C7565F1470D2CD354B" xlink:to="loc_us-gaap_PlanNameAxis_CB181974AF965F81A2311470D2CDE12F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_B91EF5CD0622E4C269791470D2CDE1A5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_CB181974AF965F81A2311470D2CDE12F" xlink:to="loc_us-gaap_PlanNameDomain_B91EF5CD0622E4C269791470D2CDE1A5" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandSevenStockIncentivePlanMember" xlink:label="loc_pcrx_TwoThousandSevenStockIncentivePlanMember_293ECF540C0AF326262B1470D2CD761B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_B91EF5CD0622E4C269791470D2CDE1A5" xlink:to="loc_pcrx_TwoThousandSevenStockIncentivePlanMember_293ECF540C0AF326262B1470D2CD761B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIncentivePlan2011Member" xlink:label="loc_pcrx_StockIncentivePlan2011Member_9B78F16D2BE7EB1370CF1470D2CDA59C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_B91EF5CD0622E4C269791470D2CDE1A5" xlink:to="loc_pcrx_StockIncentivePlan2011Member_9B78F16D2BE7EB1370CF1470D2CDA59C" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_InducementPlan2014Member" xlink:label="loc_pcrx_InducementPlan2014Member_F42EA40967AC8A5E9FF61470D2CDABA3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_B91EF5CD0622E4C269791470D2CDE1A5" xlink:to="loc_pcrx_InducementPlan2014Member_F42EA40967AC8A5E9FF61470D2CDABA3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_617BDE703D3323C7565F1470D2CD354B" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SharesIssuedDuringPeriodEmployeeStockPurchasePlan" xlink:label="loc_pcrx_SharesIssuedDuringPeriodEmployeeStockPurchasePlan_6A3EE747B194780D31CC1470D2CE3A9B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_SharesIssuedDuringPeriodEmployeeStockPurchasePlan_6A3EE747B194780D31CC1470D2CE3A9B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_BE01B1DE6282760ED4C11470D2CE72C4" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_BE01B1DE6282760ED4C11470D2CE72C4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_BA5F45454D2877F282301470D2CE2923" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_BA5F45454D2877F282301470D2CE2923" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_4328E7F5E83DFD18AAD71470D2CED4BE" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_4328E7F5E83DFD18AAD71470D2CED4BE" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EmployeeStockPurchasePlanNumberofSharesAuthorized" xlink:label="loc_pcrx_EmployeeStockPurchasePlanNumberofSharesAuthorized_9EC5E6D85DB767B88B451470D2CED63B" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_EmployeeStockPurchasePlanNumberofSharesAuthorized_9EC5E6D85DB767B88B451470D2CED63B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_D9A238DFB8CE9AEDD4FC1470D2CEBA7D" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_D9A238DFB8CE9AEDD4FC1470D2CEBA7D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_2279311CFFCC400113B61470D2CED22D" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_2279311CFFCC400113B61470D2CED22D" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EmployeeStockPurchasePlanESPPSharesinESPP" xlink:label="loc_pcrx_EmployeeStockPurchasePlanESPPSharesinESPP_939A7D8137AB96C49A1D1470D2CEA7B4" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_EmployeeStockPurchasePlanESPPSharesinESPP_939A7D8137AB96C49A1D1470D2CEA7B4" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_MaximumFairMarketValuePurchaseofESPPShares" xlink:label="loc_pcrx_MaximumFairMarketValuePurchaseofESPPShares_E1C3B5FAE0FE5C04B6F11470D2CE9172" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_MaximumFairMarketValuePurchaseofESPPShares_E1C3B5FAE0FE5C04B6F11470D2CE9172" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EmployeeStockPurchasePlanfairvalue" xlink:label="loc_pcrx_EmployeeStockPurchasePlanfairvalue_C4AF3DC077E2DAA3162E1470D2CE986E" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_EmployeeStockPurchasePlanfairvalue_C4AF3DC077E2DAA3162E1470D2CE986E" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_EmployeeStockPurchasePlanNumberofSharesAvailableForPurchase" xlink:label="loc_pcrx_EmployeeStockPurchasePlanNumberofSharesAvailableForPurchase_80C866D67B235B5C7EAB1470D2CEFE82" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97644B5CFB52E7F7FF091470D2CD305B" xlink:to="loc_pcrx_EmployeeStockPurchasePlanNumberofSharesAvailableForPurchase_80C866D67B235B5C7EAB1470D2CEFE82" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockPlansDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_D33FDBCFA7E7D036FA48F9BAF24C99A6" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_5153D1D659D3D0C5750EF9BAF252FC19" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_D33FDBCFA7E7D036FA48F9BAF24C99A6" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_5153D1D659D3D0C5750EF9BAF252FC19" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_D07B49204B21A2B6815AF9BAF252EEA5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_5153D1D659D3D0C5750EF9BAF252FC19" xlink:to="loc_us-gaap_AwardTypeAxis_D07B49204B21A2B6815AF9BAF252EEA5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_EABF1AA2AA77F18F07E2F9BAF2520834" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_D07B49204B21A2B6815AF9BAF252EEA5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_EABF1AA2AA77F18F07E2F9BAF2520834" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_8B2CD8C2AEA58F8E4999F9BAF252625E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_EABF1AA2AA77F18F07E2F9BAF2520834" xlink:to="loc_us-gaap_EmployeeStockOptionMember_8B2CD8C2AEA58F8E4999F9BAF252625E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_1DBDF90A6BB88975DE48F9BAF2529C36" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_5153D1D659D3D0C5750EF9BAF252FC19" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_1DBDF90A6BB88975DE48F9BAF2529C36" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_E90EDDEF33EE151995E5F9BAF252FA03" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_1DBDF90A6BB88975DE48F9BAF2529C36" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_E90EDDEF33EE151995E5F9BAF252FA03" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CostOfSalesMember" xlink:label="loc_us-gaap_CostOfSalesMember_FC88C1803F15C822C1D2F9BAF2520877" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E90EDDEF33EE151995E5F9BAF252FA03" xlink:to="loc_us-gaap_CostOfSalesMember_FC88C1803F15C822C1D2F9BAF2520877" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_C67979F4D09E30642B25F9BAF252B962" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E90EDDEF33EE151995E5F9BAF252FA03" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_C67979F4D09E30642B25F9BAF252B962" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_6761E57566F2DB5444A9F9BAF2529993" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_E90EDDEF33EE151995E5F9BAF252FA03" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_6761E57566F2DB5444A9F9BAF2529993" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_5153D1D659D3D0C5750EF9BAF252FC19" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_8CABA55BB87E8DB42F76F9BAF253C4B2" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_8CABA55BB87E8DB42F76F9BAF253C4B2" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_Compensationexpensefromstockoptions" xlink:label="loc_pcrx_Compensationexpensefromstockoptions_1C3E0C9BD0E5BFADC481F9BAF2537F66" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:to="loc_pcrx_Compensationexpensefromstockoptions_1C3E0C9BD0E5BFADC481F9BAF2537F66" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_Compensationexpensefromemployeestockpurchaseplan" xlink:label="loc_pcrx_Compensationexpensefromemployeestockpurchaseplan_F6391FC34875762C4086F9BAF253F0D5" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:to="loc_pcrx_Compensationexpensefromemployeestockpurchaseplan_F6391FC34875762C4086F9BAF253F0D5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_12B13FF6FB25DCD3DD6EF9BBF4BBB04B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_59CE6C717C10157A3DA8F9BAF2532137" xlink:to="loc_us-gaap_ShareBasedCompensation_12B13FF6FB25DCD3DD6EF9BBF4BBB04B" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockPlansDetails3" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2757A0945EF81E8C2FB1850C858621F" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7D27D1244B9796ADCBF31850C859DF3D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2757A0945EF81E8C2FB1850C858621F" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7D27D1244B9796ADCBF31850C859DF3D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_DCC9FE91E1CD53DBB3B71850C8599B2C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7D27D1244B9796ADCBF31850C859DF3D" xlink:to="loc_us-gaap_AwardTypeAxis_DCC9FE91E1CD53DBB3B71850C8599B2C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C6636B57A5B5584EE5ED1850C85AD3E5" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_DCC9FE91E1CD53DBB3B71850C8599B2C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C6636B57A5B5584EE5ED1850C85AD3E5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_5F1167F09CAF75A0B9991850C85A59F0" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C6636B57A5B5584EE5ED1850C85AD3E5" xlink:to="loc_us-gaap_EmployeeStockOptionMember_5F1167F09CAF75A0B9991850C85A59F0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeStockMember" xlink:label="loc_us-gaap_EmployeeStockMember_AF8E35302E8C5BC7CC8118514DC0F543" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_C6636B57A5B5584EE5ED1850C85AD3E5" xlink:to="loc_us-gaap_EmployeeStockMember_AF8E35302E8C5BC7CC8118514DC0F543" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7D27D1244B9796ADCBF31850C859DF3D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_EF1A314BC2AD02F44D341850C85A5D72" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_EF1A314BC2AD02F44D341850C85A5D72" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_A4E773D2B2FE7AF0E27E1850C85A2748" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_A4E773D2B2FE7AF0E27E1850C85A2748" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_D59949D07C0B8444E6571850C85AAC94" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_D59949D07C0B8444E6571850C85AAC94" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_DE9B9A93E4095280FC1D1850C85ABEA8" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_DE9B9A93E4095280FC1D1850C85ABEA8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_B8F91A918562433562C51850C85A958A" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_B8F91A918562433562C51850C85A958A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_1CCBD8E0D8C7F229433F1850C85A2582" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_1CCBD8E0D8C7F229433F1850C85A2582" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_6AD2F2FD20BF6ED9C6321850C85A5FFF" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_6AD2F2FD20BF6ED9C6321850C85A5FFF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_F7E980432EEAAD7C06851850C85A0539" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_3933508F4E19FDF62EE91850C85A45FC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_F7E980432EEAAD7C06851850C85A0539" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_A011F75A18154D38CB421850C85A7F73" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_A011F75A18154D38CB421850C85A7F73" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_B5F9AEDC26A402B9C19A1850C85AE280" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_B5F9AEDC26A402B9C19A1850C85AE280" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_910879C6F2136906241C1850C85B9336" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_910879C6F2136906241C1850C85B9336" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_72D05F4039278505E2231850C85B4564" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_72D05F4039278505E2231850C85B4564" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_4ED4549F51075D7CC6A81850C85B2ED4" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_4ED4549F51075D7CC6A81850C85B2ED4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_AEDE13DAE2C0C4E25AA11850C85B8EE0" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_AEDE13DAE2C0C4E25AA11850C85B8EE0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_8411D03BE93213707A2C1850C85BA429" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_8411D03BE93213707A2C1850C85BA429" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_1FFB52720F28608BE9671850C85BBFF3" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_1D011249D16AA3144A7B1850C85A6C4C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_1FFB52720F28608BE9671850C85BBFF3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward" xlink:label="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward_27F0CC06044A2D960C551850C85B7ED9" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward_27F0CC06044A2D960C551850C85B7ED9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_7BD835BBE50BC537A1F21850C85B45B6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward_27F0CC06044A2D960C551850C85B7ED9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_7BD835BBE50BC537A1F21850C85B45B6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_6DFE4C72112CF600F7971850C85B086C" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward_27F0CC06044A2D960C551850C85B7ED9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_6DFE4C72112CF600F7971850C85B086C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_02C04FEF650B143A0D311850C85B0DD3" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward_27F0CC06044A2D960C551850C85B7ED9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_02C04FEF650B143A0D311850C85B0DD3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward" xlink:label="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_ED4E2A2661E85D5A1B401850C85BFF99" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_ED4E2A2661E85D5A1B401850C85BFF99" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_80F538F0F088B68C91311850C85BF21D" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_80F538F0F088B68C91311850C85BF21D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_880A49594215C828B5EC1850C85BE81F" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_880A49594215C828B5EC1850C85BE81F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_274C73FA8B514A7E0B7B1850C85BD77A" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_274C73FA8B514A7E0B7B1850C85BD77A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_72F593B72BBA60DD372D1850C85B9D0B" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward_FD3D78545382DD8A39301850C85B4A7A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_72F593B72BBA60DD372D1850C85B9D0B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_9DE3A6061F864F3D7FCE1850C85B1206" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_9DE3A6061F864F3D7FCE1850C85B1206" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_1E97AE18B3927677D89C1850C85BD1C9" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_9DE3A6061F864F3D7FCE1850C85B1206" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_1E97AE18B3927677D89C1850C85BD1C9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_14C09C34870DAB2FB75C1850C85B98F1" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_9DE3A6061F864F3D7FCE1850C85B1206" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_14C09C34870DAB2FB75C1850C85B98F1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6EE75F9AFC6D2C69228D1850C85B8DC7" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_9DE3A6061F864F3D7FCE1850C85B1206" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6EE75F9AFC6D2C69228D1850C85B8DC7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_C935D2D766A9B1610E581850C85CB1ED" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_C935D2D766A9B1610E581850C85CB1ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_06E562865B002E22A1D61850C85CE387" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_06E562865B002E22A1D61850C85CE387" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_FFD33757ECAFAB9E2AAB1850C85C620C" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_FFD33757ECAFAB9E2AAB1850C85C620C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_97C46D39B66E1F9A5B8E1850C85CB8F1" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_3C02054035445D16A8511850C85C77D8" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_97C46D39B66E1F9A5B8E1850C85CB8F1" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PerShareFairValueofEmployeeStockPurchasePlanShares" xlink:label="loc_pcrx_PerShareFairValueofEmployeeStockPurchasePlanShares_3E313E8C2A98F2F8C40318529CF6C698" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_pcrx_PerShareFairValueofEmployeeStockPurchasePlanShares_3E313E8C2A98F2F8C40318529CF6C698" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_0C5DC8DAF232AC41BC7F1853D6B7E9E1" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_14EE533B720A67C0E1601850C85AE93F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_0C5DC8DAF232AC41BC7F1853D6B7E9E1" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockPlansTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_414A51E9AD2B75DFB7686F31F70173BE" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ScheduleOfSharesAvailableForIssuanceTableTextBlock" xlink:label="loc_pcrx_ScheduleOfSharesAvailableForIssuanceTableTextBlock_6E04E20A4A49CDF6DFE06F31F7016299" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_414A51E9AD2B75DFB7686F31F70173BE" xlink:to="loc_pcrx_ScheduleOfSharesAvailableForIssuanceTableTextBlock_6E04E20A4A49CDF6DFE06F31F7016299" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_DC16967EE2F311C008D56F31F7011A95" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_414A51E9AD2B75DFB7686F31F70173BE" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_DC16967EE2F311C008D56F31F7011A95" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_5AC8DD05A6FA6B4E90626F31F7017633" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_414A51E9AD2B75DFB7686F31F70173BE" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_5AC8DD05A6FA6B4E90626F31F7017633" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_84271D24734136C13A166F31F701876E" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_414A51E9AD2B75DFB7686F31F70173BE" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_84271D24734136C13A166F31F701876E" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockholdersEquity" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_1063D88B1B8A39587FC06F31F5A743D1" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_E90D9B7D9A8613F1667F6F31F5A7E1BB" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_1063D88B1B8A39587FC06F31F5A743D1" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_E90D9B7D9A8613F1667F6F31F5A7E1BB" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockholdersEquityDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_1FC3180920A92558EAD3188854F536AF" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_1FC3180920A92558EAD3188854F536AF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7612625C512D27E51586188854F556E3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7612625C512D27E51586188854F556E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_AC0097A4E5B751B55B7D188E0A6FC60A" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_AC0097A4E5B751B55B7D188E0A6FC60A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues" xlink:label="loc_pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues_6D6119C104319E076E4C188854F6ED3B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_pcrx_StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues_6D6119C104319E076E4C188854F6ED3B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_CD033C26B29803F14B33188854F67197" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_SharePrice_CD033C26B29803F14B33188854F67197" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_C571662644E3299F9D87188E0D5916CA" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_C571662644E3299F9D87188E0D5916CA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_7AEE663A18CB7B3DE083188854F6C9FC" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/positiveLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_7AEE663A18CB7B3DE083188854F6C9FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_AD8F4F9A987D04E79707188854F78322" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_AD8F4F9A987D04E79707188854F78322" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions" xlink:label="loc_pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions_32E49423EFFDF34C3293188854F76545" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_pcrx_StockIssuedDuringPeriodSharesTreasuryStockReissuedforExerciseofStockOptions_32E49423EFFDF34C3293188854F76545" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_35D61CC312B53844F5B7188854F75B8C" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7F44AFA22DE7D5DEF064188854F53058" xlink:to="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_35D61CC312B53844F5B7188854F75B8C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_B45EB5CA77CC7430FDD1188854F8728A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_35D61CC312B53844F5B7188854F75B8C" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_B45EB5CA77CC7430FDD1188854F8728A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_pcrx_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6CAED72488B5B92CA9A3188854F8DD2D" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_35D61CC312B53844F5B7188854F75B8C" xlink:to="loc_pcrx_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6CAED72488B5B92CA9A3188854F8DD2D" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockholdersEquityDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_32F9FC22728872D611C7188854E3FB88" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_C5C39D092D0B10BAA386188854E36F0A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_32F9FC22728872D611C7188854E3FB88" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_C5C39D092D0B10BAA386188854E36F0A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_ADEBC0929331788F8150188854E4261F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_C5C39D092D0B10BAA386188854E36F0A" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_ADEBC0929331788F8150188854E4261F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_EB77BC9B1B00C1666D82188854E5588D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_ADEBC0929331788F8150188854E4261F" xlink:to="loc_us-gaap_EquityComponentDomain_EB77BC9B1B00C1666D82188854E5588D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_9C7E78A24B8930AA2731188854E5C730" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_EB77BC9B1B00C1666D82188854E5588D" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_9C7E78A24B8930AA2731188854E5C730" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_8F3BC5D411155A9AB544188854E5CB44" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_C5C39D092D0B10BAA386188854E36F0A" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_8F3BC5D411155A9AB544188854E5CB44" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward" xlink:label="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_8F3BC5D411155A9AB544188854E5CB44" xlink:to="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_126D6266939BCAF413C0188854E6BFA8" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_126D6266939BCAF413C0188854E6BFA8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_2D9BA9727CFE3BD621FF188854E6E738" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_2D9BA9727CFE3BD621FF188854E6E738" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_CDFEC80382047EA9A2E8188854E614E6" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_CDFEC80382047EA9A2E8188854E614E6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A2ACAD7B2D14FAC4B946188854E7EE1B" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_AccumulatedOtherComprehensiveIncomeLossNetOfTaxRollForward_92AB5617FC191D0AC6C0188854E5B65F" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_A2ACAD7B2D14FAC4B946188854E7EE1B" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/StockholdersEquityTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_C4C19E63FBBCF846E5766F31F49791A2" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_0326A619DEC0BC1095ED6F31F49882E6" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_C4C19E63FBBCF846E5766F31F49791A2" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_0326A619DEC0BC1095ED6F31F49882E6" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SubsequentEventsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_74631270DE9BAFEBE490A3675F091C05" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_EB16DC0487E5D0BA6F35A3675F09918E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_74631270DE9BAFEBE490A3675F091C05" xlink:to="loc_us-gaap_SubsequentEventTable_EB16DC0487E5D0BA6F35A3675F09918E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_5DA80E36542D5913AFA3A3675F0AAD91" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_EB16DC0487E5D0BA6F35A3675F09918E" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_5DA80E36542D5913AFA3A3675F0AAD91" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_845EE72E88CE09FCD224A3675F0A4051" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5DA80E36542D5913AFA3A3675F0AAD91" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_845EE72E88CE09FCD224A3675F0A4051" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_23DBB42C8B055C0629E7A3675F0A0F3D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_845EE72E88CE09FCD224A3675F0A4051" xlink:to="loc_us-gaap_SubsequentEventMember_23DBB42C8B055C0629E7A3675F0A0F3D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_D61C70ED66DD0571BF3EA3675F0A0CE2" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_EB16DC0487E5D0BA6F35A3675F09918E" xlink:to="loc_us-gaap_SubsequentEventLineItems_D61C70ED66DD0571BF3EA3675F0A0CE2" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ConversionRequestConvertibleSeniorNotes" xlink:label="loc_pcrx_ConversionRequestConvertibleSeniorNotes_7FFC6100C767D71C93A1A3675F0B45D1" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_D61C70ED66DD0571BF3EA3675F0A0CE2" xlink:to="loc_pcrx_ConversionRequestConvertibleSeniorNotes_7FFC6100C767D71C93A1A3675F0B45D1" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TradingDayObservationPeriod" xlink:label="loc_pcrx_TradingDayObservationPeriod_6BA29E0C0F521A82BE0AA3675F0B9DDB" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_D61C70ED66DD0571BF3EA3675F0A0CE2" xlink:to="loc_pcrx_TradingDayObservationPeriod_6BA29E0C0F521A82BE0AA3675F0B9DDB" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SubsequentEventsNotes" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_1DD0398851029D6CA156A342DEA926EA" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_42A8C442308087DDD367A34210C4BC6A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_1DD0398851029D6CA156A342DEA926EA" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_42A8C442308087DDD367A34210C4BC6A" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_531CD0806F208310C0E36F31F4C00AD8" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_EC79F8CF814C586C1E6C6F31F4C03692" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_531CD0806F208310C0E36F31F4C00AD8" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_EC79F8CF814C586C1E6C6F31F4C03692" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_3CF963EF814397D8B50BB3654A2D1B0C" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LiquidityAbstract" xlink:label="loc_pcrx_LiquidityAbstract_8D3FE115A7066C61E141B3654A2DC05B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3CF963EF814397D8B50BB3654A2D1B0C" xlink:to="loc_pcrx_LiquidityAbstract_8D3FE115A7066C61E141B3654A2DC05B" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_pcrx_SummaryOfSignificantAccountingPoliciesTable_F0AB2BA39E2449F1EF66B3654A2DE262" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_LiquidityAbstract_8D3FE115A7066C61E141B3654A2DC05B" xlink:to="loc_pcrx_SummaryOfSignificantAccountingPoliciesTable_F0AB2BA39E2449F1EF66B3654A2DE262" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_EBA7CD38CAC84747123AB3654A2D3EBE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesTable_F0AB2BA39E2449F1EF66B3654A2DE262" xlink:to="loc_us-gaap_DebtInstrumentAxis_EBA7CD38CAC84747123AB3654A2D3EBE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1B9244F96B67793CA29EB3654A2D6906" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_EBA7CD38CAC84747123AB3654A2D3EBE" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1B9244F96B67793CA29EB3654A2D6906" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_TwoThousandNineteenSeniorConvertibleNotesMember" xlink:label="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_08EB58733B12D144B329B3654A2D57D3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1B9244F96B67793CA29EB3654A2D6906" xlink:to="loc_pcrx_TwoThousandNineteenSeniorConvertibleNotesMember_08EB58733B12D144B329B3654A2D57D3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesTable_F0AB2BA39E2449F1EF66B3654A2DE262" xlink:to="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_CA9FE951A000875B191EB3654A2DD2B3" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_CA9FE951A000875B191EB3654A2DD2B3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_A39AF440B71BD2557F7CB3654A2D12E3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_A39AF440B71BD2557F7CB3654A2D12E3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleConversionValue" xlink:label="loc_pcrx_DebtInstrumentConvertibleConversionValue_EE7B2AD7A3DD70694F08B3654A2D5A50" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:to="loc_pcrx_DebtInstrumentConvertibleConversionValue_EE7B2AD7A3DD70694F08B3654A2D5A50" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_DebtInstrumentConvertibleConversionPremiumShares" xlink:label="loc_pcrx_DebtInstrumentConvertibleConversionPremiumShares_E3A7CB3F0CB09F42383DB3654A2DD7CC" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_pcrx_SummaryOfSignificantAccountingPoliciesLineItems_F160548A805799472E07B3654A2D73E3" xlink:to="loc_pcrx_DebtInstrumentConvertibleConversionPremiumShares_E3A7CB3F0CB09F42383DB3654A2DD7CC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RevenueRecognitionAbstract" xlink:label="loc_us-gaap_RevenueRecognitionAbstract_C08CF823A01AC397BD66B3654A2D39D4" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3CF963EF814397D8B50BB3654A2D1B0C" xlink:to="loc_us-gaap_RevenueRecognitionAbstract_C08CF823A01AC397BD66B3654A2D39D4" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_BeginningPeriodPriorToProductExpirationAllowedForReturningProduct" xlink:label="loc_pcrx_BeginningPeriodPriorToProductExpirationAllowedForReturningProduct_0976D9FD050621BBE4B0B3654A2DAC5A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_C08CF823A01AC397BD66B3654A2D39D4" xlink:to="loc_pcrx_BeginningPeriodPriorToProductExpirationAllowedForReturningProduct_0976D9FD050621BBE4B0B3654A2DAC5A" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned" xlink:label="loc_pcrx_PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned_17E443DB826CC8FA2A26B3654A2DE2C1" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_C08CF823A01AC397BD66B3654A2D39D4" xlink:to="loc_pcrx_PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned_17E443DB826CC8FA2A26B3654A2DE2C1" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails2" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_600361B7484F19B491A16F31F55CD3BE" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_600361B7484F19B491A16F31F55CD3BE" xlink:to="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_1E999A4BDE9A13DB935A6F31F55CEE6A" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_1E999A4BDE9A13DB935A6F31F55CEE6A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_4F3B5B2C41ADC76451626F31F55D345D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_1E999A4BDE9A13DB935A6F31F55CEE6A" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_4F3B5B2C41ADC76451626F31F55D345D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SalesRevenueGoodsNetMember" xlink:label="loc_us-gaap_SalesRevenueGoodsNetMember_2E6150EB28CDC39074C56F31F55D709B" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_4F3B5B2C41ADC76451626F31F55D345D" xlink:to="loc_us-gaap_SalesRevenueGoodsNetMember_2E6150EB28CDC39074C56F31F55D709B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_DA97B4EC952CC4C395766F31F55D77BC" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_DA97B4EC952CC4C395766F31F55D77BC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_3EA9B602AF2BA9A39F8B6F31F55D46DA" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_DA97B4EC952CC4C395766F31F55D77BC" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_3EA9B602AF2BA9A39F8B6F31F55D46DA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_C7982C79B97AC6A825A86F31F55DC44D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_3EA9B602AF2BA9A39F8B6F31F55D46DA" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_C7982C79B97AC6A825A86F31F55DC44D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="loc_us-gaap_MajorCustomersAxis_986BCE28F0FA06A342CE6F31F55D8E54" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:to="loc_us-gaap_MajorCustomersAxis_986BCE28F0FA06A342CE6F31F55D8E54" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorCustomersAxis_986BCE28F0FA06A342CE6F31F55D8E54" xlink:to="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_LargestCustomerMember" xlink:label="loc_pcrx_LargestCustomerMember_F779840B54EC7D56FE5C6F31F55DCD62" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:to="loc_pcrx_LargestCustomerMember_F779840B54EC7D56FE5C6F31F55DCD62" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SecondLargestCustomerMember" xlink:label="loc_pcrx_SecondLargestCustomerMember_DFE42F05A60C0BCFA7946F31F55E77E3" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:to="loc_pcrx_SecondLargestCustomerMember_DFE42F05A60C0BCFA7946F31F55E77E3" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ThirdLargestCustomerMember" xlink:label="loc_pcrx_ThirdLargestCustomerMember_D86ABF03E87B8676D44C6F31F55E6DFC" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:to="loc_pcrx_ThirdLargestCustomerMember_D86ABF03E87B8676D44C6F31F55E6DFC" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_CustomersOutsideUSMember" xlink:label="loc_pcrx_CustomersOutsideUSMember_8EBF01976DB56F84029D6F31F55F5560" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NameOfMajorCustomerDomain_765CC0AB4AA511C7FEDD6F31F55D8C2F" xlink:to="loc_pcrx_CustomersOutsideUSMember_8EBF01976DB56F84029D6F31F55F5560" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_4145F3CE8A8ACAF6A9D46F31F55F74C8" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_94F6F4B31DCA48F783C46F31F55CA3AE" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_4145F3CE8A8ACAF6A9D46F31F55F74C8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_3902357EB36AB8E08B766F31F55FC153" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_4145F3CE8A8ACAF6A9D46F31F55F74C8" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_3902357EB36AB8E08B766F31F55FC153" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RestrictedCashAndInvestmentsAbstract" xlink:label="loc_us-gaap_RestrictedCashAndInvestmentsAbstract_DEF16761F21F91E67C8A6F31F55F4891" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_600361B7484F19B491A16F31F55CD3BE" xlink:to="loc_us-gaap_RestrictedCashAndInvestmentsAbstract_DEF16761F21F91E67C8A6F31F55F4891" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_AmountReceivedInLockboxRestrictedForPaymentOfRoyaltyInterest" xlink:label="loc_pcrx_AmountReceivedInLockboxRestrictedForPaymentOfRoyaltyInterest_8323302BACF8FA322BA56F31F55F7A6F" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndInvestmentsAbstract_DEF16761F21F91E67C8A6F31F55F4891" xlink:to="loc_pcrx_AmountReceivedInLockboxRestrictedForPaymentOfRoyaltyInterest_8323302BACF8FA322BA56F31F55F7A6F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_PaymentPeriodOfRoyaltyInterestFromRestrictedAmountInLockbox" xlink:label="loc_pcrx_PaymentPeriodOfRoyaltyInterestFromRestrictedAmountInLockbox_AFC57E5F4F0E87A2DC2A6F31F55FC7D5" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndInvestmentsAbstract_DEF16761F21F91E67C8A6F31F55F4891" xlink:to="loc_pcrx_PaymentPeriodOfRoyaltyInterestFromRestrictedAmountInLockbox_AFC57E5F4F0E87A2DC2A6F31F55FC7D5" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesDetails3" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_91E0D73057B31F82C00EA41DFF425789" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_45546B97A244B4A45F5FA41DFF43C43D" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_91E0D73057B31F82C00EA41DFF425789" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_45546B97A244B4A45F5FA41DFF43C43D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_BAE923A49A4A0DB1EAF2A41DFF430FB4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_45546B97A244B4A45F5FA41DFF43C43D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_BAE923A49A4A0DB1EAF2A41DFF430FB4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_EAC0F848C518AAE73EEDA41DFF44CF74" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_BAE923A49A4A0DB1EAF2A41DFF430FB4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_EAC0F848C518AAE73EEDA41DFF44CF74" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_1CF5222305D2468DA395A41DFF449814" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_EAC0F848C518AAE73EEDA41DFF44CF74" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_1CF5222305D2468DA395A41DFF449814" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ComputerEquipmentAndSoftwareMember" xlink:label="loc_pcrx_ComputerEquipmentAndSoftwareMember_5C75CB5241F886AC7B55A41DFF450CA7" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_EAC0F848C518AAE73EEDA41DFF44CF74" xlink:to="loc_pcrx_ComputerEquipmentAndSoftwareMember_5C75CB5241F886AC7B55A41DFF450CA7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_5C32F7CC2AAE9100B28FA41DFF46668A" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_EAC0F848C518AAE73EEDA41DFF44CF74" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_5C32F7CC2AAE9100B28FA41DFF46668A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2BF8065C2838592C3BD8A41DFF46D546" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_45546B97A244B4A45F5FA41DFF43C43D" xlink:to="loc_us-gaap_RangeAxis_2BF8065C2838592C3BD8A41DFF46D546" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_248C22E04BF8678C1903A41DFF462A7E" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2BF8065C2838592C3BD8A41DFF46D546" xlink:to="loc_us-gaap_RangeMember_248C22E04BF8678C1903A41DFF462A7E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_C83D2334532DA4F4E1BBA41DFF47955C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_248C22E04BF8678C1903A41DFF462A7E" xlink:to="loc_us-gaap_MinimumMember_C83D2334532DA4F4E1BBA41DFF47955C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_2F64787256A9E9B3C510A41DFF472FD8" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_248C22E04BF8678C1903A41DFF462A7E" xlink:to="loc_us-gaap_MaximumMember_2F64787256A9E9B3C510A41DFF472FD8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_ED77DD43FA68842EB088A41DFF489572" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_45546B97A244B4A45F5FA41DFF43C43D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_ED77DD43FA68842EB088A41DFF489572" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_AC3E05ACC4A31CD6C3D6A41DFF48734C" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_ED77DD43FA68842EB088A41DFF489572" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_AC3E05ACC4A31CD6C3D6A41DFF48734C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_FC0F2455052D6434BAAEA41DFF48FA2F" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_91E0D73057B31F82C00EA41DFF425789" xlink:to="loc_us-gaap_IncomeTaxDisclosureAbstract_FC0F2455052D6434BAAEA41DFF48FA2F" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses" xlink:label="loc_pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses_B6552D5F2815EFDB90E0A41DFF4894E2" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FC0F2455052D6434BAAEA41DFF48FA2F" xlink:to="loc_pcrx_ProceedsFromSaleOfUnusedNetOperatingLosses_B6552D5F2815EFDB90E0A41DFF4894E2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_B198F7CD4DD4523B7223A41DFF49C595" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_91E0D73057B31F82C00EA41DFF425789" xlink:to="loc_us-gaap_SegmentReportingAbstract_B198F7CD4DD4523B7223A41DFF49C595" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_3FD4F98EDFADC759C988A41DFF4910AA" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_B198F7CD4DD4523B7223A41DFF49C595" xlink:to="loc_us-gaap_NumberOfReportableSegments_3FD4F98EDFADC759C988A41DFF4910AA" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:type="locator"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock" xlink:label="loc_pcrx_BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock_59EA436C553F90DD3043A367629533D4" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_pcrx_BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock_59EA436C553F90DD3043A367629533D4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_FEFDBFD350FAA215909AA367629517F5" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_UseOfEstimates_FEFDBFD350FAA215909AA367629517F5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_LiquidityDisclosureTextBlock" xlink:label="loc_us-gaap_LiquidityDisclosureTextBlock_12E28E84BD99DDF50F55A367629607E0" xlink:type="locator"/>
<presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_LiquidityDisclosureTextBlock_12E28E84BD99DDF50F55A367629607E0" xlink:type="arc"/>
<loc xlink:href="pcrx-20141231.xsd#pcrx_SeniorConvertibleNotesPolicyTextBlock" xlink:label="loc_pcrx_SeniorConvertibleNotesPolicyTextBlock_12A87A1408730B8A6B20A3676296FF2A" xlink:type="locator"/>
<presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_pcrx_SeniorConvertibleNotesPolicyTextBlock_12A87A1408730B8A6B20A3676296FF2A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_0D0AD9C2BBDB87B7C6E5A367629608E3" xlink:type="locator"/>
<presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_RevenueRecognitionPolicyTextBlock_0D0AD9C2BBDB87B7C6E5A367629608E3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MajorCustomersPolicyPolicyTextBlock" xlink:label="loc_us-gaap_MajorCustomersPolicyPolicyTextBlock_E34778979D7EAB682CB1A367629605F6" xlink:type="locator"/>
<presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_MajorCustomersPolicyPolicyTextBlock_E34778979D7EAB682CB1A367629605F6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_350BE659C8C4B7C409F6A3676297C85D" xlink:type="locator"/>
<presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_350BE659C8C4B7C409F6A3676297C85D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_AD3AF1098B3819C75EDEA3676297712A" xlink:type="locator"/>
<presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_AD3AF1098B3819C75EDEA3676297712A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_8EBD3E99BC7BABF288EDA3676297E89F" xlink:type="locator"/>
<presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_8EBD3E99BC7BABF288EDA3676297E89F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_MarketableSecuritiesPolicy" xlink:label="loc_us-gaap_MarketableSecuritiesPolicy_DE91458786EDD7E03357A3676298F550" xlink:type="locator"/>
<presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_MarketableSecuritiesPolicy_DE91458786EDD7E03357A3676298F550" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_7FA9ABB3F5637773D447A36762987CF0" xlink:type="locator"/>
<presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_7FA9ABB3F5637773D447A36762987CF0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_4DD4E6A296B10A45E4C6A36762987170" xlink:type="locator"/>
<presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_4DD4E6A296B10A45E4C6A36762987170" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_E17928ED3E03EEB675E4A36762990CEC" xlink:type="locator"/>
<presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_E17928ED3E03EEB675E4A36762990CEC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:label="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_953FCC7628226C75F286A3676299969E" xlink:type="locator"/>
<presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_953FCC7628226C75F286A3676299969E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_DebtPolicyTextBlock" xlink:label="loc_us-gaap_DebtPolicyTextBlock_5E1932C94716508E1715A39324A90136" xlink:type="locator"/>
<presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_DebtPolicyTextBlock_5E1932C94716508E1715A39324A90136" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_FB5550F7DFF9D6F86F55A3676299A97E" xlink:type="locator"/>
<presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_FB5550F7DFF9D6F86F55A3676299A97E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_744A4063922E0DF8D847A36762998174" xlink:type="locator"/>
<presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_744A4063922E0DF8D847A36762998174" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_4895CDDB1A4FE5852860A367629A0360" xlink:type="locator"/>
<presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_4895CDDB1A4FE5852860A367629A0360" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_8950FA4C993B5FEF7009A367629A7D77" xlink:type="locator"/>
<presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_8950FA4C993B5FEF7009A367629A7D77" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_9B5A2B9E969304409DD2A367629ACA85" xlink:type="locator"/>
<presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_9B5A2B9E969304409DD2A367629ACA85" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_629A059853083578EEA1A367629BDA98" xlink:type="locator"/>
<presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_12CCF0C71B0A675BACE3A367629444F8" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_629A059853083578EEA1A367629BDA98" xlink:type="arc"/>
</presentationLink>
<presentationLink xlink:role="http://www.pacira.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_3D0EB41F462E4205E6E26F31F611B20D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_C0EB129C2075A51E5A606F31F6110C35" xlink:type="locator"/>
<presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3D0EB41F462E4205E6E26F31F611B20D" xlink:to="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_C0EB129C2075A51E5A606F31F6110C35" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2013/elts/us-gaap-2013-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_47812CA844135FD7F5FE6F31F6110EE2" xlink:type="locator"/>
<presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3D0EB41F462E4205E6E26F31F611B20D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_47812CA844135FD7F5FE6F31F6110EE2" xlink:type="arc"/>
</presentationLink>
</linkbase>

↑Top
Filing Submission 0001396814-15-000003   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Mon., May 6, 6:04:42.2pm ET