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Pacira BioSciences, Inc. – ‘10-K’ for 12/31/21 – ‘EX-101.SCH’

On:  Monday, 2/28/22, at 4:26pm ET   ·   For:  12/31/21   ·   Accession #:  1396814-22-21   ·   File #:  1-35060

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  As Of               Filer                 Filing    For·On·As Docs:Size

 2/28/22  Pacira BioSciences, Inc.          10-K       12/31/21  128:17M

Annual Report   —   Form 10-K

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        10-K - Pcrx - 12.31.2021                            HTML   1.80M 
 2: EX-4.4      Instrument Defining the Rights of Security Holders  HTML    497K 
 3: EX-4.5      Instrument Defining the Rights of Security Holders  HTML     51K 
 4: EX-10.3     Material Contract                                   HTML     44K 
 6: EX-10.36    Material Contract                                   HTML    276K 
 7: EX-10.37    Material Contract                                   HTML    161K 
 8: EX-10.38    Material Contract                                   HTML     38K 
 5: EX-10.4     Material Contract                                   HTML     45K 
 9: EX-21.1     Subsidiaries List                                   HTML     33K 
10: EX-23.1     Consent of Expert or Counsel                        HTML     31K 
11: EX-31.1     Certification -- §302 - SOA'02                      HTML     35K 
12: EX-31.2     Certification -- §302 - SOA'02                      HTML     35K 
13: EX-32.1     Certification -- §906 - SOA'02                      HTML     33K 
19: R1          Cover                                               HTML     96K 
20: R2          Audit Information                                   HTML     36K 
21: R3          Consolidated Balance Sheets                         HTML    155K 
22: R4          Consolidated Balance Sheets (Parenthetical)         HTML     49K 
23: R5          Consolidated Statements of Operations               HTML    132K 
24: R6          Consolidated Statements of Comprehensive Income     HTML     58K 
                (Loss)                                                           
25: R7          Consolidated Statements of Stockholders' Equity     HTML    118K 
26: R8          Consolidated Statements of Stockholders' Equity     HTML     33K 
                (Parenthetical)                                                  
27: R9          Consolidated Statements of Cash Flows               HTML    166K 
28: R10         Description of Business                             HTML     39K 
29: R11         Summary of Significant Accounting Policies          HTML     80K 
30: R12         Recent Accounting Pronouncements                    HTML     49K 
31: R13         Revenue                                             HTML     88K 
32: R14         Acquisitions                                        HTML     79K 
33: R15         Inventories                                         HTML     40K 
34: R16         Fixed Assets                                        HTML     46K 
35: R17         Leases                                              HTML     60K 
36: R18         Goodwill and Intangible Assets                      HTML     62K 
37: R19         Accrued Expenses                                    HTML     45K 
38: R20         Debt                                                HTML    110K 
39: R21         Financial Instruments                               HTML    122K 
40: R22         Stockholders' Equity                                HTML     56K 
41: R23         Stock Plans                                         HTML    138K 
42: R24         Net Income (Loss) Per Share                         HTML     64K 
43: R25         Income Taxes                                        HTML    117K 
44: R26         Employee Benefit Plans                              HTML     38K 
45: R27         Acquisition-Related Charges and Product             HTML     60K 
                Discontinuation, Net                                             
46: R28         Commercial Partners and Other Agreements            HTML     44K 
47: R29         Related Party Transactions                          HTML     34K 
48: R30         Commitments and Contingencies                       HTML     50K 
49: R31         Subsequent Events                                   HTML     33K 
50: R32         Summary of Significant Accounting Policies          HTML    151K 
                (Policies)                                                       
51: R33         Summary of Significant Accounting Policies          HTML     60K 
                (Tables)                                                         
52: R34         Revenue (Tables)                                    HTML     78K 
53: R35         Acquisitions (Tables)                               HTML     69K 
54: R36         Inventories (Tables)                                HTML     41K 
55: R37         Fixed Assets (Tables)                               HTML     47K 
56: R38         Leases (Tables)                                     HTML     60K 
57: R39         Goodwill and Intangible Assets (Tables)             HTML     62K 
58: R40         Accrued Expenses (Tables)                           HTML     43K 
59: R41         Debt (Tables)                                       HTML     79K 
60: R42         Financial Instruments (Tables)                      HTML    113K 
61: R43         Stockholders' Equity (Tables)                       HTML     51K 
62: R44         Stock Plans (Tables)                                HTML    145K 
63: R45         Net Income (Loss) Per Share (Tables)                HTML     65K 
64: R46         Income Taxes (Tables)                               HTML    113K 
65: R47         Acquisition-Related Charges and Product             HTML     50K 
                Discontinuation, Net (Tables)                                    
66: R48         Description of Business (Details)                   HTML     35K 
67: R49         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     47K 
                Concentration of Major Customers (Details)                       
68: R50         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -Fixed   HTML     42K 
                Assets (Details)                                                 
69: R51         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     51K 
                Narrative (Details)                                              
70: R52         Recent Accounting Pronouncements (Details)          HTML     42K 
71: R53         REVENUE - Sales and Valuation Accruals (Details)    HTML     56K 
72: R54         REVENUE - Narrative (Details)                       HTML     36K 
73: R55         REVENUE- Disaggregation (Details)                   HTML     45K 
74: R56         ACQUISITIONS - Narrative (Details)                  HTML    106K 
75: R57         ACQUISITIONS - Contingent Consideration Flexion     HTML     47K 
                Acquisition (Details)                                            
76: R58         ACQUISITIONS - Schedule of Assets and Liabilities   HTML     87K 
                Acquired (Details)                                               
77: R59         ACQUISITIONS - Flexion Results (Details)            HTML     37K 
78: R60         ACQUISITIONS - Schedule of Pro Forma Information    HTML     42K 
                (Details)                                                        
79: R61         INVENTORIES - Components of Inventory (Details)     HTML     41K 
80: R62         FIXED ASSETS - Schedule of Useful Lives (Details)   HTML     51K 
81: R63         FIXED ASSETS - Narrative (Details)                  HTML     45K 
82: R64         LEASES - Narrative (Details)                        HTML     41K 
83: R65         LEASES - Summary of operating lease cost and other  HTML     48K 
                operating lease information (Details)                            
84: R66         LEASES - Schedule of maturities of operating lease  HTML     50K 
                liabilities (Details)                                            
85: R67         GOODWILL AND INTANGIBLE ASSETS - Goodwill           HTML     43K 
                (Details)                                                        
86: R68         GOODWILL AND INTANGIBLE ASSETS - Narrative          HTML     60K 
                (Details)                                                        
87: R69         GOODWILL AND INTANGIBLE ASSETS - Intangible Assets  HTML     55K 
                (Details)                                                        
88: R70         Accrued Expenses (Details)                          HTML     54K 
89: R71         DEBT - Carrying Value of Debt (Details)             HTML     57K 
90: R72         DEBT - Narrative (Details)                          HTML    264K 
91: R73         DEBT - Schedule of Debt (Details)                   HTML     62K 
92: R74         DEBT - Schedule of Interest Expense (Details)       HTML     48K 
93: R75         FINANCIAL INSTRUMENTS - Fair Value of Liabilities   HTML     96K 
                Measured on a Recurring Basis (Details)                          
94: R76         FINANCIAL INSTRUMENTS - Narrative (Details)         HTML    141K 
95: R77         FINANCIAL INSTRUMENTS - Schedule of Fair Value      HTML     49K 
                Inputs and Valuation (Details)                                   
96: R78         FINANCIAL INSTRUMENTS - Contingent Consideration    HTML     42K 
                Rollforward (Details)                                            
97: R79         FINANCIAL INSTRUMENTS - Schedule of Investments at  HTML     62K 
                Amortized Cost and Fair Value (Details)                          
98: R80         STOCKHOLDERS' EQUITY - Narrative (Details)          HTML     44K 
99: R81         Stockholders' Equity - Aoci (Details)               HTML     51K 
100: R82         STOCK PLANS - Narrative (Details)                   HTML     61K  
101: R83         STOCK PLANS - Stock Incentive Plans (Details)       HTML     52K  
102: R84         STOCK PLANS - Compensation Expense (Details)        HTML     50K  
103: R85         STOCK PLANS - Stock Option Activity (Details)       HTML     93K  
104: R86         STOCK PLANS - Valuation Assumptions (Details)       HTML     56K  
105: R87         STOCK PLANS - RSU Activity (Details)                HTML     61K  
106: R88         Net Income (LOSS) PER SHARE - Calculation           HTML     81K  
                (Details)                                                        
107: R89         Net Income (LOSS) PER SHARE - Antidilutive          HTML     41K  
                Securities (Details)                                             
108: R90         INCOME TAXES - Narrative (Details)                  HTML    110K  
109: R91         INCOME TAXES - Current and Deferred Income Taxes    HTML     66K  
                (Details)                                                        
110: R92         INCOME TAXES - Reconciliation of Effective Tax      HTML     62K  
                Rate (Details)                                                   
111: R93         INCOME TAXES - Deferred Tax Assets and Liabilities  HTML     64K  
                (Details)                                                        
112: R94         INCOME TAXES - Unrecognized Tax Benefits (Details)  HTML     38K  
113: R95         Employee Benefit Plans (Details)                    HTML     48K  
114: R96         ACQUISITION-RELATED CHARGES AND PRODUCT             HTML     59K  
                DISCONTINUATION, NET - Product Discontinuance                    
                (Details)                                                        
115: R97         ACQUISITION-RELATED CHARGES AND PRODUCT             HTML     46K  
                DISCONTINUATION, NET - Flexion (Details)                         
116: R98         ACQUISITION-RELATED CHARGES AND PRODUCT             HTML     43K  
                DISCONTINUATION, NET - MyoScience (Details)                      
117: R99         Acquisition-Related Charges and Product             HTML     35K  
                Discontinuation, Net - Nuance (Details)                          
118: R100        ACQUISITION-RELATED CHARGES AND PRODUCT             HTML     36K  
                DISCONTINUATION, NET - DepoCyte Discontinuation                  
                (Details)                                                        
119: R101        ACQUISITION-RELATED CHARGES AND PRODUCT             HTML     33K  
                DISCONTINUATION, NET - Department of Justice                     
                (Details)                                                        
120: R102        Commercial Partners and Other Agreements (Details)  HTML     57K  
121: R103        Related Party Transactions (Details)                HTML     41K  
122: R104        Commitments and Contingencies (Details)             HTML     67K  
123: R105        Subsequent Events (Details)                         HTML     44K  
126: XML         IDEA XML File -- Filing Summary                      XML    225K  
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125: EXCEL       IDEA Workbook of Financial Reports                  XLSX    176K  
15: EX-101.CAL  XBRL Calculations -- pcrx-20211231_cal               XML    315K 
16: EX-101.DEF  XBRL Definitions -- pcrx-20211231_def                XML   1.42M 
17: EX-101.LAB  XBRL Labels -- pcrx-20211231_lab                     XML   2.82M 
18: EX-101.PRE  XBRL Presentations -- pcrx-20211231_pre              XML   1.84M 
14: EX-101.SCH  XBRL Schema -- pcrx-20211231                         XSD    293K 
127: JSON        XBRL Instance as JSON Data -- MetaLinks              640±   929K  
128: ZIP         XBRL Zipped Folder -- 0001396814-22-000021-xbrl      Zip   1.07M

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<link:definition> 2317303 - Disclosure - ACQUISITIONS (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACQUISITIONSNarrativeDetails" roleURI="http://www.pacira.com/role/ACQUISITIONSNarrativeDetails">
<link:definition> 2418409 - Disclosure - ACQUISITIONS - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
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<link:definition> 2419410 - Disclosure - ACQUISITIONS - Contingent Consideration Flexion Acquisition (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACQUISITIONSScheduleofAssetsandLiabilitiesAcquiredDetails" roleURI="http://www.pacira.com/role/ACQUISITIONSScheduleofAssetsandLiabilitiesAcquiredDetails">
<link:definition> 2420411 - Disclosure - ACQUISITIONS - Schedule of Assets and Liabilities Acquired (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACQUISITIONSFlexionResultsDetails" roleURI="http://www.pacira.com/role/ACQUISITIONSFlexionResultsDetails">
<link:definition> 2421412 - Disclosure - ACQUISITIONS - Flexion Results (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACQUISITIONSScheduleofProFormaInformationDetails" roleURI="http://www.pacira.com/role/ACQUISITIONSScheduleofProFormaInformationDetails">
<link:definition> 2422413 - Disclosure - ACQUISITIONS - Schedule of Pro Forma Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INVENTORIES" roleURI="http://www.pacira.com/role/INVENTORIES">
<link:definition> 2123106 - Disclosure - INVENTORIES </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INVENTORIESTables" roleURI="http://www.pacira.com/role/INVENTORIESTables">
<link:definition> 2324304 - Disclosure - INVENTORIES (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INVENTORIESComponentsofInventoryDetails" roleURI="http://www.pacira.com/role/INVENTORIESComponentsofInventoryDetails">
<link:definition> 2425414 - Disclosure - INVENTORIES - Components of Inventory (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FIXEDASSETS" roleURI="http://www.pacira.com/role/FIXEDASSETS">
<link:definition> 2126107 - Disclosure - FIXED ASSETS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FIXEDASSETSTables" roleURI="http://www.pacira.com/role/FIXEDASSETSTables">
<link:definition> 2327305 - Disclosure - FIXED ASSETS (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FIXEDASSETSScheduleofUsefulLivesDetails" roleURI="http://www.pacira.com/role/FIXEDASSETSScheduleofUsefulLivesDetails">
<link:definition> 2428415 - Disclosure - FIXED ASSETS - Schedule of Useful Lives (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FIXEDASSETSNarrativeDetails" roleURI="http://www.pacira.com/role/FIXEDASSETSNarrativeDetails">
<link:definition> 2429416 - Disclosure - FIXED ASSETS - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASES" roleURI="http://www.pacira.com/role/LEASES">
<link:definition> 2130108 - Disclosure - LEASES </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASESTables" roleURI="http://www.pacira.com/role/LEASESTables">
<link:definition> 2331306 - Disclosure - LEASES (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASESNarrativeDetails" roleURI="http://www.pacira.com/role/LEASESNarrativeDetails">
<link:definition> 2432417 - Disclosure - LEASES - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASESSummaryofoperatingleasecostandotheroperatingleaseinformationDetails" roleURI="http://www.pacira.com/role/LEASESSummaryofoperatingleasecostandotheroperatingleaseinformationDetails">
<link:definition> 2433418 - Disclosure - LEASES - Summary of operating lease cost and other operating lease information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASESScheduleofmaturitiesofoperatingleaseliabilitiesDetails" roleURI="http://www.pacira.com/role/LEASESScheduleofmaturitiesofoperatingleaseliabilitiesDetails">
<link:definition> 2434419 - Disclosure - LEASES - Schedule of maturities of operating lease liabilities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="LEASESScheduleofmaturitiesofoperatingleaseliabilitiesDetails_1" roleURI="http://www.pacira.com/role/LEASESScheduleofmaturitiesofoperatingleaseliabilitiesDetails_1">
<link:definition> 2434419 - Disclosure - LEASES - Schedule of maturities of operating lease liabilities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GOODWILLANDINTANGIBLEASSETS" roleURI="http://www.pacira.com/role/GOODWILLANDINTANGIBLEASSETS">
<link:definition> 2135109 - Disclosure - GOODWILL AND INTANGIBLE ASSETS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GOODWILLANDINTANGIBLEASSETSTables" roleURI="http://www.pacira.com/role/GOODWILLANDINTANGIBLEASSETSTables">
<link:definition> 2336307 - Disclosure - GOODWILL AND INTANGIBLE ASSETS (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GOODWILLANDINTANGIBLEASSETSGoodwillDetails" roleURI="http://www.pacira.com/role/GOODWILLANDINTANGIBLEASSETSGoodwillDetails">
<link:definition> 2437420 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Goodwill (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GOODWILLANDINTANGIBLEASSETSNarrativeDetails" roleURI="http://www.pacira.com/role/GOODWILLANDINTANGIBLEASSETSNarrativeDetails">
<link:definition> 2438421 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="GOODWILLANDINTANGIBLEASSETSIntangibleAssetsDetails" roleURI="http://www.pacira.com/role/GOODWILLANDINTANGIBLEASSETSIntangibleAssetsDetails">
<link:definition> 2439422 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Intangible Assets (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACCRUEDEXPENSES" roleURI="http://www.pacira.com/role/ACCRUEDEXPENSES">
<link:definition> 2140110 - Disclosure - ACCRUED EXPENSES </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACCRUEDEXPENSESTables" roleURI="http://www.pacira.com/role/ACCRUEDEXPENSESTables">
<link:definition> 2341308 - Disclosure - ACCRUED EXPENSES (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="ACCRUEDEXPENSESDetails" roleURI="http://www.pacira.com/role/ACCRUEDEXPENSESDetails">
<link:definition> 2442423 - Disclosure - ACCRUED EXPENSES (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBT" roleURI="http://www.pacira.com/role/DEBT">
<link:definition> 2143111 - Disclosure - DEBT </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBTTables" roleURI="http://www.pacira.com/role/DEBTTables">
<link:definition> 2344309 - Disclosure - DEBT (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBTCarryingValueofDebtDetails" roleURI="http://www.pacira.com/role/DEBTCarryingValueofDebtDetails">
<link:definition> 2445424 - Disclosure - DEBT - Carrying Value of Debt (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBTNarrativeDetails" roleURI="http://www.pacira.com/role/DEBTNarrativeDetails">
<link:definition> 2446425 - Disclosure - DEBT - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBTScheduleofDebtDetails" roleURI="http://www.pacira.com/role/DEBTScheduleofDebtDetails">
<link:definition> 2447426 - Disclosure - DEBT - Schedule of Debt (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="DEBTScheduleofInterestExpenseDetails" roleURI="http://www.pacira.com/role/DEBTScheduleofInterestExpenseDetails">
<link:definition> 2448427 - Disclosure - DEBT - Schedule of Interest Expense (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTS" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTS">
<link:definition> 2149112 - Disclosure - FINANCIAL INSTRUMENTS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSTables" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSTables">
<link:definition> 2350310 - Disclosure - FINANCIAL INSTRUMENTS (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSFairValueofLiabilitiesMeasuredonaRecurringBasisDetails" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSFairValueofLiabilitiesMeasuredonaRecurringBasisDetails">
<link:definition> 2451428 - Disclosure - FINANCIAL INSTRUMENTS - Fair Value of Liabilities Measured on a Recurring Basis (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSNarrativeDetails" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSNarrativeDetails">
<link:definition> 2452429 - Disclosure - FINANCIAL INSTRUMENTS - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSScheduleofFairValueInputsandValuationDetails" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSScheduleofFairValueInputsandValuationDetails">
<link:definition> 2453430 - Disclosure - FINANCIAL INSTRUMENTS - Schedule of Fair Value Inputs and Valuation (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSContingentConsiderationRollforwardDetails" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSContingentConsiderationRollforwardDetails">
<link:definition> 2454431 - Disclosure - FINANCIAL INSTRUMENTS - Contingent Consideration Rollforward (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="FINANCIALINSTRUMENTSScheduleofInvestmentsatAmortizedCostandFairValueDetails" roleURI="http://www.pacira.com/role/FINANCIALINSTRUMENTSScheduleofInvestmentsatAmortizedCostandFairValueDetails">
<link:definition> 2455432 - Disclosure - FINANCIAL INSTRUMENTS - Schedule of Investments at Amortized Cost and Fair Value (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKHOLDERSEQUITY" roleURI="http://www.pacira.com/role/STOCKHOLDERSEQUITY">
<link:definition> 2156113 - Disclosure - STOCKHOLDERS' EQUITY </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKHOLDERSEQUITYTables" roleURI="http://www.pacira.com/role/STOCKHOLDERSEQUITYTables">
<link:definition> 2357311 - Disclosure - STOCKHOLDERS' EQUITY (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKHOLDERSEQUITYNarrativeDetails" roleURI="http://www.pacira.com/role/STOCKHOLDERSEQUITYNarrativeDetails">
<link:definition> 2458433 - Disclosure - STOCKHOLDERS' EQUITY - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKHOLDERSEQUITYAOCIDetails" roleURI="http://www.pacira.com/role/STOCKHOLDERSEQUITYAOCIDetails">
<link:definition> 2459434 - Disclosure - STOCKHOLDERS' EQUITY - AOCI (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANS" roleURI="http://www.pacira.com/role/STOCKPLANS">
<link:definition> 2160114 - Disclosure - STOCK PLANS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSTables" roleURI="http://www.pacira.com/role/STOCKPLANSTables">
<link:definition> 2361312 - Disclosure - STOCK PLANS (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSNarrativeDetails" roleURI="http://www.pacira.com/role/STOCKPLANSNarrativeDetails">
<link:definition> 2462435 - Disclosure - STOCK PLANS - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSStockIncentivePlansDetails" roleURI="http://www.pacira.com/role/STOCKPLANSStockIncentivePlansDetails">
<link:definition> 2463436 - Disclosure - STOCK PLANS - Stock Incentive Plans (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSCompensationExpenseDetails" roleURI="http://www.pacira.com/role/STOCKPLANSCompensationExpenseDetails">
<link:definition> 2464437 - Disclosure - STOCK PLANS - Compensation Expense (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSStockOptionActivityDetails" roleURI="http://www.pacira.com/role/STOCKPLANSStockOptionActivityDetails">
<link:definition> 2465438 - Disclosure - STOCK PLANS - Stock Option Activity (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSValuationAssumptionsDetails" roleURI="http://www.pacira.com/role/STOCKPLANSValuationAssumptionsDetails">
<link:definition> 2466439 - Disclosure - STOCK PLANS - Valuation Assumptions (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="STOCKPLANSRSUActivityDetails" roleURI="http://www.pacira.com/role/STOCKPLANSRSUActivityDetails">
<link:definition> 2467440 - Disclosure - STOCK PLANS - RSU Activity (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="NETINCOMELOSSPERSHARE" roleURI="http://www.pacira.com/role/NETINCOMELOSSPERSHARE">
<link:definition> 2168115 - Disclosure - NET INCOME (LOSS) PER SHARE </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="NETINCOMELOSSPERSHARETables" roleURI="http://www.pacira.com/role/NETINCOMELOSSPERSHARETables">
<link:definition> 2369313 - Disclosure - NET INCOME (LOSS) PER SHARE (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="NETINCOMELOSSPERSHARECalculationDetails" roleURI="http://www.pacira.com/role/NETINCOMELOSSPERSHARECalculationDetails">
<link:definition> 2470441 - Disclosure - NET INCOME (LOSS) PER SHARE - Calculation (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="NETINCOMELOSSPERSHAREAntidilutiveSecuritiesDetails" roleURI="http://www.pacira.com/role/NETINCOMELOSSPERSHAREAntidilutiveSecuritiesDetails">
<link:definition> 2471442 - Disclosure - NET INCOME (LOSS) PER SHARE - Antidilutive Securities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INCOMETAXES" roleURI="http://www.pacira.com/role/INCOMETAXES">
<link:definition> 2172116 - Disclosure - INCOME TAXES </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INCOMETAXESTables" roleURI="http://www.pacira.com/role/INCOMETAXESTables">
<link:definition> 2373314 - Disclosure - INCOME TAXES (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType id="INCOMETAXESNarrativeDetails" roleURI="http://www.pacira.com/role/INCOMETAXESNarrativeDetails">
<link:definition> 2474443 - Disclosure - INCOME TAXES - Narrative (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<xs:element id="pcrx_InducementPlan2014Member" abstract="true" name="InducementPlan2014Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementOfZILRETTASalesOf250MillionMember" abstract="true" name="AchievementOfZILRETTASalesOf250MillionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtInstrumentPrepaymentPenaltyPercentYear1" abstract="false" name="DebtInstrumentPrepaymentPenaltyPercentYear1" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_NumberOfMajorCustomers" abstract="false" name="NumberOfMajorCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
<xs:element id="pcrx_ConvertibleSeniorNotesDue2025Member" abstract="true" name="ConvertibleSeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_GenascenceCorporationMember" abstract="true" name="GenascenceCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax" abstract="false" name="MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_RetirementOfEquityComponentOfConvertibleSeniorNotes" abstract="false" name="RetirementOfEquityComponentOfConvertibleSeniorNotes" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_LegalFeesMember" abstract="true" name="LegalFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementofRegulatoryMilestoneMember" abstract="true" name="AchievementofRegulatoryMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ExpectedAdditionalNetOperatingLossesInYearSix" abstract="false" name="ExpectedAdditionalNetOperatingLossesInYearSix" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_CodaBioTherapeuticsIncMember" abstract="true" name="CodaBioTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtInstrumentConvertibleAssumedBorrowingRate" abstract="false" name="DebtInstrumentConvertibleAssumedBorrowingRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_DebtInstrumentMarketPrice" abstract="false" name="DebtInstrumentMarketPrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
<xs:element id="pcrx_ScheduleOfInterestExpenseTableTextBlock" abstract="false" name="ScheduleOfInterestExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
<xs:element id="pcrx_ReserveForPromptPayDiscountMember" abstract="true" name="ReserveForPromptPayDiscountMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_NumberOfLocationsNewOperatingLeaseLiability" abstract="false" name="NumberOfLocationsNewOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
<xs:element id="pcrx_SecondPriceOptionMember" abstract="true" name="SecondPriceOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ConvertibleSeniorNotes2019Member" abstract="true" name="ConvertibleSeniorNotes2019Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_LitigationInvestigationTerm" abstract="false" name="LitigationInvestigationTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_FlexionTherapeuticsIncMember" abstract="true" name="FlexionTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_EmployeeStockPurchasePlanESPPSharesinESPP" abstract="false" name="EmployeeStockPurchasePlanESPPSharesinESPP" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarningsPerShare" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarningsPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
<xs:element id="pcrx_AcquisitionRelatedChargesProductDiscontinuationAndOther" abstract="false" name="AcquisitionRelatedChargesProductDiscontinuationAndOther" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_PaymentsForDebtConversionPremiums" abstract="false" name="PaymentsForDebtConversionPremiums" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_GeneQuineMember" abstract="true" name="GeneQuineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ExpectedAdditionalNetOperatingLossesInYearTwo" abstract="false" name="ExpectedAdditionalNetOperatingLossesInYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_IncomeLossfromContinuingOperationsbeforeIncomeTaxesTotal" abstract="false" name="IncomeLossfromContinuingOperationsbeforeIncomeTaxesTotal" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_AchievementOfZILRETTASalesOf500MillionMember" abstract="true" name="AchievementOfZILRETTASalesOf500MillionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_EXPARELMember" abstract="true" name="EXPARELMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ContingentConsiderationNoncurrent" abstract="false" name="ContingentConsiderationNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtConversionConvertedInstrumentWarrantsOrRightsIssuedPerPrincipalAmount" abstract="false" name="DebtConversionConvertedInstrumentWarrantsOrRightsIssuedPerPrincipalAmount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_Accruedresearchanddevelopmentexpenses" abstract="false" name="Accruedresearchanddevelopmentexpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtConversionAndRedemptionTermsDomain" abstract="true" name="DebtConversionAndRedemptionTermsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_SkyePharmaHoldingIncMember" abstract="true" name="SkyePharmaHoldingIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_COMMERCIALPARTNERSANDOTHERAGREEMENTSTableTextBlock" abstract="false" name="COMMERCIALPARTNERSANDOTHERAGREEMENTSTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
<xs:element id="pcrx_DeferredTaxAssetsGrossNetofDeferredTaxLiabilitiesBeforeValuationAllowance" abstract="false" name="DeferredTaxAssetsGrossNetofDeferredTaxLiabilitiesBeforeValuationAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_FlexionAcquisitionMember" abstract="true" name="FlexionAcquisitionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementOfDevelopmentAndCommercialMilestonesMember" abstract="true" name="AchievementOfDevelopmentAndCommercialMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_BusinessCombinationConsiderationTransferredLiabilitiesIncurredContingentConsideration" abstract="false" name="BusinessCombinationConsiderationTransferredLiabilitiesIncurredContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ContingentConsideration" abstract="false" name="ContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_MyoscienceAcquisitionMember" abstract="true" name="MyoscienceAcquisitionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementOfSalesRelatedMilestonesMember" abstract="true" name="AchievementOfSalesRelatedMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_CommercialPartnersAndAgreementsTextBlock" abstract="false" name="CommercialPartnersAndAgreementsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
<xs:element id="pcrx_TELABioMember" abstract="true" name="TELABioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_CollaborativeArrangementOptionToTerminateDaysFromMaterialBreach" abstract="false" name="CollaborativeArrangementOptionToTerminateDaysFromMaterialBreach" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_IncomeTaxProvisionTable" abstract="true" name="IncomeTaxProvisionTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
<xs:element id="pcrx_AcquisitionRelatedFeesMember" abstract="true" name="AcquisitionRelatedFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_SpineBioPharmaLLCMember" abstract="true" name="SpineBioPharmaLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementOfDevelopmentAndRegulatoryMilestonesMember" abstract="true" name="AchievementOfDevelopmentAndRegulatoryMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ThirdLargestCustomerMember" abstract="true" name="ThirdLargestCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ExpectedAdditionalNetOperatingLossesInYearAfterYearSix" abstract="false" name="ExpectedAdditionalNetOperatingLossesInYearAfterYearSix" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_IncreaseDecreaseInInterestExpense" abstract="false" name="IncreaseDecreaseInInterestExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ConvertibleSeniorNotesDue2024Member" abstract="true" name="ConvertibleSeniorNotesDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtConversionTermsBusinessDayImmediatelyPrecedingOctober12021Member" abstract="true" name="DebtConversionTermsBusinessDayImmediatelyPrecedingOctober12021Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_SharebasedCompensationArrangementbySharebasedPaymentAwardIncreaseInNumberofSharesAuthorized" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardIncreaseInNumberofSharesAuthorized" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_FiniteLivedIntangibleAssetsMeasurementInput" abstract="false" name="FiniteLivedIntangibleAssetsMeasurementInput" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssets" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_BusinessCombinationConsiderationTransferredLiabilitiesIncurredDebt" abstract="false" name="BusinessCombinationConsiderationTransferredLiabilitiesIncurredDebt" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentBasisSpreadTwoOnVariableRate" abstract="false" name="DebtInstrumentBasisSpreadTwoOnVariableRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_ConcentrationRiskNumberofCustomers" abstract="false" name="ConcentrationRiskNumberofCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
<xs:element id="pcrx_RemainingPaymentRequiredUponFullSettlementOfNotes" abstract="false" name="RemainingPaymentRequiredUponFullSettlementOfNotes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_StockPurchasedAndIssuedDuringPeriodSharesEmployeeStockPurchasePlans" abstract="false" name="StockPurchasedAndIssuedDuringPeriodSharesEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_CollaborativeArrangementOptionToTerminateDaysFromPaymentObligation" abstract="false" name="CollaborativeArrangementOptionToTerminateDaysFromPaymentObligation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_AratanaTherapeuticsIncMember" abstract="true" name="AratanaTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtInstrumentConversionObligationNumberOfConsecutiveTradingDays" abstract="false" name="DebtInstrumentConversionObligationNumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_ClassOfWarrantOrRightExercisePriceAnnualProductSalesThreshold" abstract="false" name="ClassOfWarrantOrRightExercisePriceAnnualProductSalesThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ConcentrationRiskNumberOfProducts" abstract="false" name="ConcentrationRiskNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
<xs:element id="pcrx_PaymentOfEarlyTerminationFees" abstract="false" name="PaymentOfEarlyTerminationFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ProceedsFromConvertibleOptionComponentOfConvertibleDebt" abstract="false" name="ProceedsFromConvertibleOptionComponentOfConvertibleDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_AchievementOfMilestoneAxis" abstract="true" name="AchievementOfMilestoneAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
<xs:element id="pcrx_DebtInstrumentPrepaymentPenaltyPercentYear2" abstract="false" name="DebtInstrumentPrepaymentPenaltyPercentYear2" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_StockIncentivePlan2011Member" abstract="true" name="StockIncentivePlan2011Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_HongKongPharmaTainuoLtdMember" abstract="true" name="HongKongPharmaTainuoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DeferredTaxAssetsStockBasedCompensation" abstract="false" name="DeferredTaxAssetsStockBasedCompensation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_MajorCustomerTwoMember" abstract="true" name="MajorCustomerTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ConvertibleSeniorNotes2025Member" abstract="true" name="ConvertibleSeniorNotes2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_LongTermInvestmentsMember" abstract="true" name="LongTermInvestmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_IoveraMemberMember" abstract="true" name="IoveraMemberMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ZILRETTAMember" abstract="true" name="ZILRETTAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ContingentConsiderationMember" abstract="true" name="ContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition" abstract="false" name="AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_EmployeeStockPurchasePlanNumberofSharesAvailableForPurchase" abstract="false" name="EmployeeStockPurchasePlanNumberofSharesAvailableForPurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_FortisMember" abstract="true" name="FortisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_BupivacaineLiposomeInjectableSuspensionMember" abstract="true" name="BupivacaineLiposomeInjectableSuspensionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ProductReturnsRebatesandOtherFees" abstract="false" name="ProductReturnsRebatesandOtherFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ContingentConsiderationCurrent" abstract="false" name="ContingentConsiderationCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod6" abstract="false" name="FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod6" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DePuySynthesSalesIncMember" abstract="true" name="DePuySynthesSalesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_CollaborativeArrangementUpfrontPayment" abstract="false" name="CollaborativeArrangementUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" abstract="false" name="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_ProceedsFromSharesIssuedUnderEmployeeStockPurchasePlan" abstract="false" name="ProceedsFromSharesIssuedUnderEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_IncomeTaxProvisionLineItems" abstract="true" name="IncomeTaxProvisionLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="pcrx_TotalMilestonePaymentsYetToBePaidInConnectionAcquisition" abstract="false" name="TotalMilestonePaymentsYetToBePaidInConnectionAcquisition" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" abstract="false" name="RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
<xs:element id="pcrx_EurofarmaLabatoriesSAMember" abstract="true" name="EurofarmaLabatoriesSAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_TransactionCostsAttributableToTheEquityComponentOfConvertibleDebt" abstract="false" name="TransactionCostsAttributableToTheEquityComponentOfConvertibleDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_AchievementOfMilestoneDomain" abstract="true" name="AchievementOfMilestoneDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_EffectiveIncomeTaxRateReconciliationForeign" abstract="false" name="EffectiveIncomeTaxRateReconciliationForeign" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_ConvertibleSeniorNotesDueMay2024Member" abstract="true" name="ConvertibleSeniorNotesDueMay2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_OtherTaxAttributesSubjectToLimitation" abstract="false" name="OtherTaxAttributesSubjectToLimitation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentDiscountRate" abstract="false" name="DebtInstrumentDiscountRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_ConversionPremiumOn2022NotesMember" abstract="true" name="ConversionPremiumOn2022NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis" abstract="true" name="MilestonePaymentsForProductInConnectionWithAcquisitionByStageAtWhichTheyArePayableAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
<xs:element id="pcrx_CollaborativeArrangementOptionToExtendTerm" abstract="false" name="CollaborativeArrangementOptionToExtendTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_TermLoanBFacilityDue2026Member" abstract="true" name="TermLoanBFacilityDue2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtInstrumentConvertibleConversionPremiumShares" abstract="false" name="DebtInstrumentConvertibleConversionPremiumShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
<xs:element id="pcrx_AmortizationPeriodOfTransactionCostsAttributableToLiabilityComponentOfConvertibleDebt" abstract="false" name="AmortizationPeriodOfTransactionCostsAttributableToLiabilityComponentOfConvertibleDebt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_DepoCyteMember" abstract="true" name="DepoCyteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition" abstract="false" name="AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentConvertibleCarryingAmountOfLiabilityComponent" abstract="false" name="DebtInstrumentConvertibleCarryingAmountOfLiabilityComponent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentBasisSpreadOneOnVariableRate" abstract="false" name="DebtInstrumentBasisSpreadOneOnVariableRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_BusinessCombinationAcquisitionAndIntegrationRelatedCosts" abstract="false" name="BusinessCombinationAcquisitionAndIntegrationRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod4" abstract="false" name="FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod4" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_AccruedExpensesTable" abstract="true" name="AccruedExpensesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
<xs:element id="pcrx_LargestCustomerMember" abstract="true" name="LargestCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_RestrictedStockUnitsMoneyStockOptionsAndCommonStockMember" abstract="true" name="RestrictedStockUnitsMoneyStockOptionsAndCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ContingentConsiderationPaymentTerm" abstract="false" name="ContingentConsiderationPaymentTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_ExpectedAdditionalNetOperatingLossesInYearOne" abstract="false" name="ExpectedAdditionalNetOperatingLossesInYearOne" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_EffectiveIncomeTaxRateReconciliation338gElectionPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliation338gElectionPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_CollaborativeArrangementMilestonePaymentsToBeReceivedMaximum" abstract="false" name="CollaborativeArrangementMilestonePaymentsToBeReceivedMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember" abstract="true" name="UponAnnualNetSalesReachingDollar500.0MillionThresholdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueRollforward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="pcrx_DebtRedemptionPriceDueToFundamentalChangeAsPercentageOfPrincipalAmount" abstract="false" name="DebtRedemptionPriceDueToFundamentalChangeAsPercentageOfPrincipalAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_MeasurementInputExpectedMilestonePaymentMember" abstract="true" name="MeasurementInputExpectedMilestonePaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AchievementOfZILRETTASalesOf375MillionMember" abstract="true" name="AchievementOfZILRETTASalesOf375MillionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_DebtConversionAndRedemptionTermsAxis" abstract="true" name="DebtConversionAndRedemptionTermsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
<xs:element id="pcrx_FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod1" abstract="false" name="FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod1" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_AccountsReceivablePaymentTerms" abstract="false" name="AccountsReceivablePaymentTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
<xs:element id="pcrx_MajorCustomerOneMember" abstract="true" name="MajorCustomerOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AccruedEndOfTermFeeCurrent" abstract="false" name="AccruedEndOfTermFeeCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentConversionObligationPremiumOnCommonStock" abstract="false" name="DebtInstrumentConversionObligationPremiumOnCommonStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_AccruedExpensesLineItems" abstract="true" name="AccruedExpensesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="pcrx_DebtInstrumentCustomaryEventsofDefaultPercentageofPrincipalandAccruedandUnpaidInterestDueandPayableUponDefault" abstract="false" name="DebtInstrumentCustomaryEventsofDefaultPercentageofPrincipalandAccruedandUnpaidInterestDueandPayableUponDefault" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
<xs:element id="pcrx_EmployeeStockPurchasePlanESPP2014Member" abstract="true" name="EmployeeStockPurchasePlanESPP2014Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod5" abstract="false" name="FiniteLivedIntangibleAssetsAmortizationExpensePerYearPeriod5" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAAverageRemainingContractualTermRollforward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
<xs:element id="pcrx_SecondLargestCustomerMember" abstract="true" name="SecondLargestCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
<xs:element id="pcrx_AcquisitionRelatedChargesProductDiscontinuationAndOtherExpenses" abstract="false" name="AcquisitionRelatedChargesProductDiscontinuationAndOtherExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
<xs:element id="pcrx_DebtInstrumentCovenantLeverageRatioMaximum" abstract="false" name="DebtInstrumentCovenantLeverageRatioMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
<xs:element id="pcrx_EmployeeStockPurchasePlanNumberofSharesAuthorized" abstract="false" name="EmployeeStockPurchasePlanNumberofSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
</xs:schema>

6 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/29/24  Pacira BioSciences, Inc.          10-K       12/31/23  123:17M
 2/28/23  Pacira BioSciences, Inc.          10-K       12/31/22  118:16M
11/03/22  Pacira BioSciences, Inc.          10-Q        9/30/22   90:11M
 8/04/22  Pacira BioSciences, Inc.          S-8         8/04/22    5:116K
 8/03/22  Pacira BioSciences, Inc.          10-Q        6/30/22   90:10M
 5/04/22  Pacira BioSciences, Inc.          10-Q        3/31/22   92:9.5M

32 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

12/09/21  Pacira BioSciences, Inc.          8-K:1,2,8,912/06/21   12:1.4M                                   Toppan Merrill/FA
11/19/21  Flexion Therapeutics Inc.         8-K:1,2,3,511/19/21   13:374K                                   Toppan Merrill/FA
11/19/21  Pacira BioSciences, Inc.          8-K:1,2,8,911/19/21   12:452K                                   Toppan Merrill/FA
10/12/21  Pacira BioSciences, Inc.          8-K:1,2,7,910/11/21   17:3.7M                                   Toppan Merrill/FA
 6/11/21  Pacira BioSciences, Inc.          8-K:5,9     6/08/21   11:296K                                   Toppan Merrill/FA
 3/01/21  Pacira BioSciences, Inc.          10-K       12/31/20  113:13M
12/07/20  Pacira BioSciences, Inc.          8-K:5,9    12/04/20   13:254K
 7/10/20  Pacira BioSciences, Inc.          8-K:1,2,3,8 7/10/20   13:1.1M                                   Toppan Merrill/FA
 6/11/20  Pacira BioSciences, Inc.          8-K:5,9     6/05/20   11:331K                                   Toppan Merrill/FA
 5/07/20  Pacira BioSciences, Inc.          10-Q        3/31/20   87:8.1M
 2/21/20  Pacira BioSciences, Inc.          10-K       12/31/19  101:13M
 5/02/19  Pacira BioSciences, Inc.          10-Q        3/31/19   80:6.9M
 4/09/19  Pacira BioSciences, Inc.          8-K:2,5,8,9 4/09/19    4:190K                                   Toppan Merrill/FA
 3/05/19  Pacira BioSciences, Inc.          8-K:1,8,9   3/04/19    3:914K                                   Toppan Merrill/FA
 5/02/17  Flexion Therapeutics Inc.         8-K:1,2,3,8 5/02/17    5:714K                                   Donnelley … Solutions/FA
 3/13/17  Pacira BioSciences, Inc.          8-K:1,2,3,8 3/07/17    2:910K                                   Toppan Merrill/FA
 8/04/16  Pacira BioSciences, Inc.          10-Q        6/30/16   68:5.5M
 2/25/16  Pacira BioSciences, Inc.          10-K       12/31/15   87:10M                                    Workiva Inc Wde… FA01/FA
 7/30/15  Pacira BioSciences, Inc.          10-Q        6/30/15   72:5.7M
 4/30/15  Pacira BioSciences, Inc.          10-Q        3/31/15   69:5.9M
10/30/14  Pacira BioSciences, Inc.          10-Q        9/30/14   66:6.4M
 7/31/14  Pacira BioSciences, Inc.          10-Q        6/30/14   68:7.8M
 6/04/14  Pacira BioSciences, Inc.          8-K:5,9     6/03/14    4:292K                                   Toppan Merrill/FA
 5/01/14  Pacira BioSciences, Inc.          10-Q        3/31/14   66:5.3M
10/31/13  Pacira BioSciences, Inc.          10-Q        9/30/13   64:6.5M                                   Workiva Inc.
 3/18/13  Pacira BioSciences, Inc.          8-K:1,5,9   3/13/13    8:584K                                   Toppan Merrill/FA
11/01/12  Pacira BioSciences, Inc.          10-Q        9/30/12   60:6.7M                                   Toppan Merrill/FA
 5/09/12  Pacira BioSciences, Inc.          10-Q        3/31/12   36:3.4M                                   Toppan Merrill/FA
10/31/11  Pacira BioSciences, Inc.          10-Q        9/30/11   34:4.4M                                   Toppan Merrill/FA
 2/11/11  Pacira BioSciences, Inc.          8-K:5,9     2/08/11    3:188K                                   Donnelley … Solutions/FA
 1/13/11  Pacira BioSciences, Inc.          S-1/A¶                16:5.1M                                   Donnelley … Solutions/FA
12/03/10  Pacira BioSciences, Inc.          S-1/A¶                25:7.1M                                   Donnelley … Solutions/FA
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