SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Precigen, Inc. – ‘10-K’ for 12/31/23 – ‘EX-101.DEF’

On:  Tuesday, 3/19/24, at 4:48pm ET   ·   For:  12/31/23   ·   Accession #:  1356090-24-7   ·   File #:  1-36042

Previous ‘10-K’:  ‘10-K’ on 3/6/23 for 12/31/22   ·   Next & Latest:  ‘10-K/A’ on 4/29/24 for 12/31/23   ·   21 References:   

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 3/19/24  Precigen, Inc.                    10-K       12/31/23  117:21M

Annual Report   —   Form 10-K   —   SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   2.18M 
 3: EX-10.10    Material Contract                                   HTML     46K 
 4: EX-10.11    Material Contract                                   HTML     48K 
 2: EX-10.9     Material Contract                                   HTML     42K 
 5: EX-21.1     Subsidiaries List                                   HTML     33K 
 6: EX-23.1     Consent of Expert or Counsel                        HTML     32K 
11: EX-97       Clawback Policy re: Recovery of Erroneously         HTML     51K 
                Awarded Compensation                                             
 7: EX-31.1     Certification -- §302 - SOA'02                      HTML     37K 
 8: EX-31.2     Certification -- §302 - SOA'02                      HTML     37K 
 9: EX-32.1     Certification -- §906 - SOA'02                      HTML     34K 
10: EX-32.2     Certification -- §906 - SOA'02                      HTML     34K 
17: R1          Cover Page                                          HTML     98K 
18: R2          Audit Information                                   HTML     38K 
19: R3          Consolidated Balance Sheets                         HTML    149K 
20: R4          Consolidated Balance Sheets (Parenthetical)         HTML     46K 
21: R5          Consolidated Statements of Operations               HTML    159K 
22: R6          Consolidated Statements of Operations               HTML     46K 
                (Parenthetical)                                                  
23: R7          Condensed Consolidated Statements of Comprehensive  HTML     57K 
                Income (Loss)                                                    
24: R8          Consolidated Statements of Shareholders' Equity     HTML    130K 
25: R9          Consolidated Statements of Cash Flows               HTML    165K 
26: R10         Consolidated Statements of Cash Flows               HTML     44K 
                (Reconciliation of Cash)                                         
27: R11         Consolidated Statement of Cash Flows                HTML     34K 
                (Parenthetical)                                                  
28: R12         Organization and Basis of Presentation              HTML     43K 
29: R13         Summary of Significant Accounting Policies          HTML    107K 
30: R14         Discontinued Operations                             HTML     88K 
31: R15         Investments in Joint Ventures                       HTML     41K 
32: R16         Collaboration and Licensing Revenue                 HTML     66K 
33: R17         Short-term and Long-term Investments                HTML     58K 
34: R18         Fair Value Measurements                             HTML     61K 
35: R19         Property, Plant and Equipment, Net                  HTML     49K 
36: R20         Goodwill and Intangible Assets, Net                 HTML     59K 
37: R21         Lines of Credit and Long-Term Debt                  HTML     50K 
38: R22         Income Taxes                                        HTML    121K 
39: R23         Shareholders' Equity                                HTML     50K 
40: R24         Share-Based Payments                                HTML     90K 
41: R25         Commitments and Contingencies                       HTML     41K 
42: R26         Operating Leases                                    HTML     63K 
43: R27         Segments                                            HTML    109K 
44: R28         Defined Contribution Plans                          HTML     35K 
45: R29         Summary of Significant Accounting Policies          HTML    148K 
                (Policies)                                                       
46: R30         Summary of Significant Accounting Policies          HTML     70K 
                (Tables)                                                         
47: R31         Discontinued Operations (Tables)                    HTML     85K 
48: R32         Collaboration and Licensing Revenue (Tables)        HTML     58K 
49: R33         Short-term and Long-term Investments (Tables)       HTML     59K 
50: R34         Fair Value Measurements (Tables)                    HTML     58K 
51: R35         Property, Plant and Equipment, Net (Tables)         HTML     48K 
52: R36         Goodwill and Intangible Assets, Net (Tables)        HTML     65K 
53: R37         Lines of Credit and Long-Term Debt (Tables)         HTML     42K 
54: R38         Income Taxes (Tables)                               HTML    125K 
55: R39         Shareholders' Equity (Tables)                       HTML     40K 
56: R40         Share-Based Payments (Tables)                       HTML     89K 
57: R41         Operating Leases (Tables)                           HTML     64K 
58: R42         Segments (Tables)                                   HTML    105K 
59: R43         Organization and Basis of Presentation -            HTML     63K 
                Additional Information (Details)                                 
60: R44         Summary of Significant Accounting Policies -        HTML     75K 
                Additional Information (Details)                                 
61: R45         Summary of Significant Accounting Policies -        HTML     43K 
                Rollforward of Allowance for Credit Losses                       
                (Details)                                                        
62: R46         Summary of Significant Accounting Policies -        HTML     56K 
                Estimated Useful Lives of Property, Plant and                    
                Equipment (Details)                                              
63: R47         Summary of Significant Accounting Policies -        HTML     60K 
                Summary of Assumptions Used in Option Pricing                    
                Model (Details)                                                  
64: R48         Summary of Significant Accounting Policies -        HTML     43K 
                Potentially Dilutive Securities Excluded from                    
                Calculation of Net Loss per Share (Details)                      
65: R49         Discontinued Operations - Narrative (Details)       HTML     65K 
66: R50         Discontinued Operations - Summary of Financial      HTML     75K 
                Results for Trans Ova (Details)                                  
67: R51         Discontinued Operations - Summary of Significant    HTML     59K 
                Non-Cash Items, Investments and Purchases of                     
                Property, Plant and Equipment on Cash Flows -                    
                Trans Ova (Details)                                              
68: R52         Discontinued Operations - Summary of Financial      HTML     48K 
                Results for MBP Titan (Details)                                  
69: R53         Discontinued Operations - Summary Of Significant    HTML     43K 
                Non-Cash Items, Investments and Purchases of                     
                Property, Plant and Equipment on Cash Flows - MBP                
                Titan (Details)                                                  
70: R54         Investments in Joint Ventures - Intrexon Energy     HTML     52K 
                Partners - Additional Information (Details)                      
71: R55         Investments in Joint Ventures - Intrexon Energy     HTML     52K 
                Partners II - Additional Information (Details)                   
72: R56         Investments in Joint Ventures - Interests in        HTML     42K 
                Intrexon Energy Partners and Intrexon Energy                     
                Partners II (Details)                                            
73: R57         Collaboration and Licensing Revenue - Summarized    HTML     51K 
                Collaboration and Licensing Revenues (Details)                   
74: R58         Collaboration and Licensing Revenue - Additional    HTML     48K 
                Information (Details)                                            
75: R59         Collaboration and Licensing Revenue - Summary of    HTML     46K 
                Deferred Revenue (Details)                                       
76: R60         Short-term and Long-term Investments - Summary of   HTML     55K 
                Amortized Cost, Gross Unrealized Gains and Losses                
                and Fair Value of Investments (Details)                          
77: R61         Short-term and Long-term Investments - Narrative    HTML     35K 
                (Details)                                                        
78: R62         Fair Value Measurements - Summary of Placement in   HTML     60K 
                the Fair Value Hierarchy of Financial Assets that                
                are Measured at Fair Value on a Recurring Basis                  
                (Details)                                                        
79: R63         Fair Value Measurements - Additional Information    HTML     39K 
                (Details)                                                        
80: R64         Property, Plant and Equipment, Net - Schedule of    HTML     57K 
                Property, Plant and Equipment (Details)                          
81: R65         Property, Plant and Equipment, Net - Additional     HTML     40K 
                Information (Details)                                            
82: R66         Goodwill and Intangible Assets, Net - Schedule of   HTML     45K 
                Changes in Carrying Amount of Goodwill (Details)                 
83: R67         Goodwill and Intangible Assets, Net - Additional    HTML     52K 
                Information (Details)                                            
84: R68         Goodwill and Intangible Assets, Net - Schedule of   HTML     47K 
                Intangible Assets (Details)                                      
85: R69         Goodwill and Intangible Assets, Net - Schedule of   HTML     48K 
                Definite-Lived Intangible Assets, Estimated Future               
                Amortization Expense (Details)                                   
86: R70         Lines of Credit and Long-Term Debt - Lines of       HTML     44K 
                Credit - Additional Information (Details)                        
87: R71         Lines of Credit and Long-Term Debt - Short-Term     HTML     67K 
                Debt and Convertible Debt - Additional Information               
                (Details)                                                        
88: R72         Lines of Credit and Long-Term Debt - Components of  HTML     48K 
                Interest Expense (Details)                                       
89: R73         Income Taxes - Components of Loss Before Income     HTML     42K 
                Taxes (Details)                                                  
90: R74         Income Taxes - Components of Income Tax Benefit     HTML     53K 
                (Details)                                                        
91: R75         Income Taxes - Schedule of Effective Income Tax     HTML     61K 
                Rate Reconciliation (Details)                                    
92: R76         Income Taxes - Schedule of Deferred Tax Assets and  HTML     75K 
                Liabilities (Details)                                            
93: R77         Income Taxes - Summary of Valuation Allowance       HTML     47K 
                (Details)                                                        
94: R78         Income Taxes - Additional Information (Details)     HTML     48K 
95: R79         Shareholders' Equity - Additional Information       HTML     54K 
                (Details)                                                        
96: R80         Shareholders' Equity - Components of Accumulated    HTML     54K 
                Other Comprehensive Income (Loss) (Details)                      
97: R81         Share-Based Payments - Schedule of Stock-based      HTML     45K 
                Compensation Expense (Details)                                   
98: R82         Share-Based Payments - Additional Information       HTML     89K 
                (Details)                                                        
99: R83         Share-Based Payments - Schedule of Stock Option     HTML     74K 
                Activity (Details)                                               
100: R84         Share-Based Payments - Schedule of Restricted       HTML     63K  
                Stock Unit Activity (Details)                                    
101: R85         Commitments and Contingencies - Contingencies -     HTML     42K  
                Additional Information (Details)                                 
102: R86         Operating Leases - Additional Information           HTML     40K  
                (Details)                                                        
103: R87         Operating Leases - Components of Lease Costs        HTML     41K  
                (Details)                                                        
104: R88         Operating Leases - Maturities of Lease Liabilities  HTML     56K  
                (Details)                                                        
105: R89         Operating Leases - Lease Terms and Discount Rates   HTML     37K  
                (Details)                                                        
106: R90         Operating Leases - Other Information (Details)      HTML     37K  
107: R91         Segments - Adjusted EBITDA by Reportable Segment    HTML     40K  
                (Details)                                                        
108: R92         Segments - Reconciliation of Net Loss Before        HTML     85K  
                Income Taxes (Details)                                           
109: R93         Segments - Revenues by Reportable Segment           HTML     43K  
                (Details)                                                        
110: R94         Segments - Additional Information (Details)         HTML     50K  
111: R95         Segments - Goodwill (Details)                       HTML     51K  
112: R96         Defined Contribution Plans - Additional             HTML     34K  
                Information (Details)                                            
114: XML         IDEA XML File -- Filing Summary                      XML    216K  
117: XML         XBRL Instance -- pgen-20231231_htm                   XML   2.17M  
113: EXCEL       IDEA Workbook of Financial Report Info              XLSX    206K  
13: EX-101.CAL  XBRL Calculations -- pgen-20231231_cal               XML    286K 
14: EX-101.DEF  XBRL Definitions -- pgen-20231231_def                XML   1.00M 
15: EX-101.LAB  XBRL Labels -- pgen-20231231_lab                     XML   1.93M 
16: EX-101.PRE  XBRL Presentations -- pgen-20231231_pre              XML   1.46M 
12: EX-101.SCH  XBRL Schema -- pgen-20231231                         XSD    221K 
115: JSON        XBRL Instance as JSON Data -- MetaLinks              648±   986K  
116: ZIP         XBRL Zipped Folder -- 0001356090-24-000007-xbrl      Zip   3.11M

‘EX-101.DEF’   —   XBRL Definitions — pgen-20231231_def

This Exhibit is an XBRL File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with the Workiva Platform -->
<!-- Copyright 2024 Workiva -->
<!-- r:63d4ae04-22fd-40c6-a830-6ea46db1b3a9,g:43913839-4ef2-4573-81b4-ab4bdaf9db52 -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
<link:roleRef roleURI="http://www.dna.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="pgen-20231231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e76b2da3-b86d-4b26-964a-468351ee69c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e76b2da3-b86d-4b26-964a-468351ee69c3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_34c87ff7-cdf4-4c85-ae88-e7ded889fb84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e76b2da3-b86d-4b26-964a-468351ee69c3" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_34c87ff7-cdf4-4c85-ae88-e7ded889fb84" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_34c87ff7-cdf4-4c85-ae88-e7ded889fb84_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_34c87ff7-cdf4-4c85-ae88-e7ded889fb84" xlink:to="loc_us-gaap_RelatedPartyDomain_34c87ff7-cdf4-4c85-ae88-e7ded889fb84_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_46371be5-7cba-4bce-9e60-9e98deb0f35d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_34c87ff7-cdf4-4c85-ae88-e7ded889fb84" xlink:to="loc_us-gaap_RelatedPartyDomain_46371be5-7cba-4bce-9e60-9e98deb0f35d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_RelatedPartiesAggregatedMember_6488207d-bc55-48c1-a278-1d8f4adca850" xlink:href="pgen-20231231.xsd#pgen_RelatedPartiesAggregatedMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_46371be5-7cba-4bce-9e60-9e98deb0f35d" xlink:to="loc_pgen_RelatedPartiesAggregatedMember_6488207d-bc55-48c1-a278-1d8f4adca850" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_e24d39e4-4dec-4459-b536-ee18bd9162bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_e24d39e4-4dec-4459-b536-ee18bd9162bd" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_5a95ab1d-abfd-44d9-9d1b-631400fac5ba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_5a95ab1d-abfd-44d9-9d1b-631400fac5ba" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_428580de-ec24-42ad-941d-37a18797a2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesAuthorized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_428580de-ec24-42ad-941d-37a18797a2b5" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_c1ac3692-104a-4206-b164-74ca1afc8c93" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesIssued"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_CommonStockSharesIssued_c1ac3692-104a-4206-b164-74ca1afc8c93" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_d7054cc6-b969-47f3-9e7c-022cfef79296" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_97fc6094-6cab-4b14-85d2-b620e08a7303" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_d7054cc6-b969-47f3-9e7c-022cfef79296" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="pgen-20231231.xsd#ConsolidatedStatementsofOperations"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_523cceb8-2885-481c-9a21-e83eff435917" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_StatementTable_523cceb8-2885-481c-9a21-e83eff435917" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_8531cffe-5ac2-402d-b33c-392c91bff5f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_523cceb8-2885-481c-9a21-e83eff435917" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_8531cffe-5ac2-402d-b33c-392c91bff5f2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_8531cffe-5ac2-402d-b33c-392c91bff5f2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_8531cffe-5ac2-402d-b33c-392c91bff5f2" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_8531cffe-5ac2-402d-b33c-392c91bff5f2_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_111ed534-9843-4aa8-b682-e924a9a1d286" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_8531cffe-5ac2-402d-b33c-392c91bff5f2" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_111ed534-9843-4aa8-b682-e924a9a1d286" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_49275e62-2cbb-4ffa-bd35-f348d55b96bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentContinuingOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_111ed534-9843-4aa8-b682-e924a9a1d286" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_49275e62-2cbb-4ffa-bd35-f348d55b96bb" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_d57caf5a-a775-4f85-ba35-fe544227620e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_523cceb8-2885-481c-9a21-e83eff435917" xlink:to="loc_srt_ProductOrServiceAxis_d57caf5a-a775-4f85-ba35-fe544227620e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d57caf5a-a775-4f85-ba35-fe544227620e_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_d57caf5a-a775-4f85-ba35-fe544227620e" xlink:to="loc_srt_ProductsAndServicesDomain_d57caf5a-a775-4f85-ba35-fe544227620e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_69344c65-91ae-4939-ac12-2dd8c19bd722" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_d57caf5a-a775-4f85-ba35-fe544227620e" xlink:to="loc_srt_ProductsAndServicesDomain_69344c65-91ae-4939-ac12-2dd8c19bd722" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_0db9cfc1-0987-479d-9efb-23c835fbf877" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_69344c65-91ae-4939-ac12-2dd8c19bd722" xlink:to="loc_us-gaap_ProductMember_0db9cfc1-0987-479d-9efb-23c835fbf877" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServiceMember_7b3d700b-1837-4f50-bc76-b3d8fbd3313f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ServiceMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_69344c65-91ae-4939-ac12-2dd8c19bd722" xlink:to="loc_us-gaap_ServiceMember_7b3d700b-1837-4f50-bc76-b3d8fbd3313f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_OtherMember_db10b0f9-72da-436f-8f85-7f792f3ce81d" xlink:href="pgen-20231231.xsd#pgen_OtherMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_69344c65-91ae-4939-ac12-2dd8c19bd722" xlink:to="loc_pgen_OtherMember_db10b0f9-72da-436f-8f85-7f792f3ce81d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_62d1f383-944f-4990-a274-68b9e6bc25aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_523cceb8-2885-481c-9a21-e83eff435917" xlink:to="loc_us-gaap_TypeOfArrangementAxis_62d1f383-944f-4990-a274-68b9e6bc25aa" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_62d1f383-944f-4990-a274-68b9e6bc25aa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_62d1f383-944f-4990-a274-68b9e6bc25aa" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_62d1f383-944f-4990-a274-68b9e6bc25aa_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e1a188c7-83d3-47d8-8ad4-08284cfeb8a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_62d1f383-944f-4990-a274-68b9e6bc25aa" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e1a188c7-83d3-47d8-8ad4-08284cfeb8a4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_1ec7c6f4-4073-40f3-bcd2-b74255005e54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e1a188c7-83d3-47d8-8ad4-08284cfeb8a4" xlink:to="loc_us-gaap_CollaborativeArrangementMember_1ec7c6f4-4073-40f3-bcd2-b74255005e54" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_474e2442-ecc7-4e72-9c01-7a2394d7ec3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenuesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_RevenuesAbstract_474e2442-ecc7-4e72-9c01-7a2394d7ec3a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_484a1434-fdf5-405d-b40e-003bc4d56cec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_474e2442-ecc7-4e72-9c01-7a2394d7ec3a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_484a1434-fdf5-405d-b40e-003bc4d56cec" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpensesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_1c78bd23-91cd-4522-b72a-d191468230ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_1c78bd23-91cd-4522-b72a-d191468230ad" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_8fe6a10a-899c-47a1-9c23-72ebaa547648" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_8fe6a10a-899c-47a1-9c23-72ebaa547648" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0ed30680-3fce-4768-b802-c6fe594a257d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0ed30680-3fce-4768-b802-c6fe594a257d" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_874bf209-7a95-47f6-a3dc-5ea13593403a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_874bf209-7a95-47f6-a3dc-5ea13593403a" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetImpairmentCharges_634ae379-5935-4d67-9cfd-bd9c1599af37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetImpairmentCharges"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_OtherAssetImpairmentCharges_634ae379-5935-4d67-9cfd-bd9c1599af37" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_ff1abd34-bb1c-4571-8708-372e966c07d7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_58ad55a5-2abc-4675-90ef-6d1235d04f9a" xlink:to="loc_us-gaap_OperatingExpenses_ff1abd34-bb1c-4571-8708-372e966c07d7" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_76d9a28d-a0eb-4106-98b0-29edc35e466f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_OperatingIncomeLoss_76d9a28d-a0eb-4106-98b0-29edc35e466f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_350175c2-0c77-407a-9e29-ca5720c777d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:to="loc_us-gaap_InterestExpense_350175c2-0c77-407a-9e29-ca5720c777d5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_c287fcd6-a487-41ed-af72-476272b3d02d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeNonoperating"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_c287fcd6-a487-41ed-af72-476272b3d02d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_3bf80547-11e4-40eb-895b-a9e35804bbb7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_3bf80547-11e4-40eb-895b-a9e35804bbb7" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_625053ad-4445-4312-be34-a149c197c1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95acea08-f856-426c-ac69-2bc07d4fbae9" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_625053ad-4445-4312-be34-a149c197c1a2" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_8bad28d8-efff-4a68-b7ed-4fea281134af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_8bad28d8-efff-4a68-b7ed-4fea281134af" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_010e3dc7-cb48-4adf-ad9a-59f941ae7cc8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_010e3dc7-cb48-4adf-ad9a-59f941ae7cc8" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c2b8cb51-847d-41fe-a475-aa5a4d00fc60" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_c2b8cb51-847d-41fe-a475-aa5a4d00fc60" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_2f28f99f-831f-4f57-9d7a-7ea686923295" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_2f28f99f-831f-4f57-9d7a-7ea686923295" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_86ec6746-1475-427d-917a-dafe8a05290b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_86ec6746-1475-427d-917a-dafe8a05290b" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_887f0ece-52a9-4bbc-a0f1-a73d2f8a4d86" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_NetIncomeLoss_887f0ece-52a9-4bbc-a0f1-a73d2f8a4d86" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_5c2844ec-ef8a-47dd-ac09-06b0529ed5b9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_5c2844ec-ef8a-47dd-ac09-06b0529ed5b9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_9c458506-23e8-45f0-a116-74d0e866ba63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_9c458506-23e8-45f0-a116-74d0e866ba63" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_2c35fa4d-67bc-4b40-b31f-2f414cb02f35" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_2c35fa4d-67bc-4b40-b31f-2f414cb02f35" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_7bf67f07-27bf-4dbf-b280-6d7e614d8f56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_7bf67f07-27bf-4dbf-b280-6d7e614d8f56" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_b48b495c-3d0a-4513-8ae5-f2a1f26ea5fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareDiluted"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_EarningsPerShareDiluted_b48b495c-3d0a-4513-8ae5-f2a1f26ea5fe" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_3dd6bd86-6a9a-49d4-a603-5a949582d681" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareBasic"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_59b1906e-51cd-4abc-9599-60ba39497d52" xlink:to="loc_us-gaap_EarningsPerShareBasic_3dd6bd86-6a9a-49d4-a603-5a949582d681" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6f2c8aa3-b5c7-45bd-b253-e2120a0e1624" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6f2c8aa3-b5c7-45bd-b253-e2120a0e1624" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_cda3003a-e7dc-4cf5-8c6c-c04348bc45d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d0bba384-dbe7-401b-ae88-343d6421f680" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_cda3003a-e7dc-4cf5-8c6c-c04348bc45d3" xlink:type="arc" order="12"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ConsolidatedStatementsofOperationsParenthetical" xlink:type="simple" xlink:href="pgen-20231231.xsd#ConsolidatedStatementsofOperationsParenthetical"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ConsolidatedStatementsofOperationsParenthetical" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_64245eee-8836-46ad-9129-029017b2ecdc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_d45f0558-cf00-4e6f-a532-4fec9b21a3d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_64245eee-8836-46ad-9129-029017b2ecdc" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_d45f0558-cf00-4e6f-a532-4fec9b21a3d3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_08d191ad-4620-4a47-9768-e2a57b3c1918" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_d45f0558-cf00-4e6f-a532-4fec9b21a3d3" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_08d191ad-4620-4a47-9768-e2a57b3c1918" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_08d191ad-4620-4a47-9768-e2a57b3c1918_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_08d191ad-4620-4a47-9768-e2a57b3c1918" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_08d191ad-4620-4a47-9768-e2a57b3c1918_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_26535741-22f6-4723-a6e4-6f20e9b59788" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_08d191ad-4620-4a47-9768-e2a57b3c1918" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_26535741-22f6-4723-a6e4-6f20e9b59788" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_a1557248-1f1e-4d0d-87b8-caa88bbe1209" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentContinuingOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_26535741-22f6-4723-a6e4-6f20e9b59788" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_a1557248-1f1e-4d0d-87b8-caa88bbe1209" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_bbb9524d-a103-4275-8dca-2569e4640654" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_d45f0558-cf00-4e6f-a532-4fec9b21a3d3" xlink:to="loc_us-gaap_TypeOfArrangementAxis_bbb9524d-a103-4275-8dca-2569e4640654" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_bbb9524d-a103-4275-8dca-2569e4640654_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_bbb9524d-a103-4275-8dca-2569e4640654" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_bbb9524d-a103-4275-8dca-2569e4640654_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0867f753-53ed-4576-8923-e94efaaa79a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_bbb9524d-a103-4275-8dca-2569e4640654" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0867f753-53ed-4576-8923-e94efaaa79a0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_d601c0fe-4d32-4531-9af7-bd5853447997" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0867f753-53ed-4576-8923-e94efaaa79a0" xlink:to="loc_us-gaap_CollaborativeArrangementMember_d601c0fe-4d32-4531-9af7-bd5853447997" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a5545132-a18e-4e7f-b3ae-91e8dad35097" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_d45f0558-cf00-4e6f-a532-4fec9b21a3d3" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a5545132-a18e-4e7f-b3ae-91e8dad35097" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_a5545132-a18e-4e7f-b3ae-91e8dad35097_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a5545132-a18e-4e7f-b3ae-91e8dad35097" xlink:to="loc_us-gaap_RelatedPartyDomain_a5545132-a18e-4e7f-b3ae-91e8dad35097_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_171aa9f9-9b95-4952-94b1-b060aba463fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a5545132-a18e-4e7f-b3ae-91e8dad35097" xlink:to="loc_us-gaap_RelatedPartyDomain_171aa9f9-9b95-4952-94b1-b060aba463fe" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_RelatedPartiesAggregatedMember_44be2257-ace6-44b0-9b22-85d72768bd31" xlink:href="pgen-20231231.xsd#pgen_RelatedPartiesAggregatedMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_171aa9f9-9b95-4952-94b1-b060aba463fe" xlink:to="loc_pgen_RelatedPartiesAggregatedMember_44be2257-ace6-44b0-9b22-85d72768bd31" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0c7af926-2ef2-4f0d-8d58-71e719ca816c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_64245eee-8836-46ad-9129-029017b2ecdc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0c7af926-2ef2-4f0d-8d58-71e719ca816c" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ConsolidatedStatementsofShareholdersEquity" xlink:type="simple" xlink:href="pgen-20231231.xsd#ConsolidatedStatementsofShareholdersEquity"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ConsolidatedStatementsofShareholdersEquity" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_dbed6382-dc7a-4968-a654-1dbc5f03146b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_23ccb796-61b5-4f43-b351-3dbb0eb14183" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_dbed6382-dc7a-4968-a654-1dbc5f03146b" xlink:to="loc_us-gaap_StatementTable_23ccb796-61b5-4f43-b351-3dbb0eb14183" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_ba225813-196a-493e-96cb-41d3e24463fa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_23ccb796-61b5-4f43-b351-3dbb0eb14183" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_ba225813-196a-493e-96cb-41d3e24463fa" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ba225813-196a-493e-96cb-41d3e24463fa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_ba225813-196a-493e-96cb-41d3e24463fa" xlink:to="loc_us-gaap_EquityComponentDomain_ba225813-196a-493e-96cb-41d3e24463fa_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_ba225813-196a-493e-96cb-41d3e24463fa" xlink:to="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_17b5a1ab-5ca6-4a85-8804-525170550775" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:to="loc_us-gaap_CommonStockMember_17b5a1ab-5ca6-4a85-8804-525170550775" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_449fbbd8-abf5-4a17-a6a8-b6ec3e5241d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_449fbbd8-abf5-4a17-a6a8-b6ec3e5241d6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_e3ebfc48-6f0c-410a-b997-e420ece7d5a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_e3ebfc48-6f0c-410a-b997-e420ece7d5a4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_958e3dda-a7d8-4850-a4cf-827a5c1c6f48" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:to="loc_us-gaap_RetainedEarningsMember_958e3dda-a7d8-4850-a4cf-827a5c1c6f48" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_d549a3ab-2d15-401a-ab9f-a37c78369459" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_73854bca-c17e-4ba7-b73e-aa2648ef02fc" xlink:to="loc_us-gaap_TreasuryStockCommonMember_d549a3ab-2d15-401a-ab9f-a37c78369459" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_a01d89ec-be05-4f79-8d9d-c53bf0f2176d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_23ccb796-61b5-4f43-b351-3dbb0eb14183" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_a01d89ec-be05-4f79-8d9d-c53bf0f2176d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_a01d89ec-be05-4f79-8d9d-c53bf0f2176d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_a01d89ec-be05-4f79-8d9d-c53bf0f2176d" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_a01d89ec-be05-4f79-8d9d-c53bf0f2176d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_b167fd69-0dc6-42d8-8576-451714f87167" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_a01d89ec-be05-4f79-8d9d-c53bf0f2176d" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_b167fd69-0dc6-42d8-8576-451714f87167" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_8d576aa0-258c-4d79-bb5f-3d2d9206e67f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_b167fd69-0dc6-42d8-8576-451714f87167" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_8d576aa0-258c-4d79-bb5f-3d2d9206e67f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_dbed6382-dc7a-4968-a654-1dbc5f03146b" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1cdb9a34-37cd-4cb4-81f4-b383918f2fac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_StockholdersEquity_1cdb9a34-37cd-4cb4-81f4-b383918f2fac" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_80f1f2f5-e34d-44c8-bd0a-5c1971d9d870" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_80f1f2f5-e34d-44c8-bd0a-5c1971d9d870" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_bcecbf43-7e1e-4df8-9b48-cdf25bbdc0c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_TreasuryStockCommonShares_bcecbf43-7e1e-4df8-9b48-cdf25bbdc0c3" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_56ce57f0-0b68-46e4-93ac-dcbc2ce3b20d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_56ce57f0-0b68-46e4-93ac-dcbc2ce3b20d" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedandStockOptionsandWarrantsExercised_b4b00b14-8fb0-4e20-8128-ad5ca57b7f6c" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedandStockOptionsandWarrantsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedandStockOptionsandWarrantsExercised_b4b00b14-8fb0-4e20-8128-ad5ca57b7f6c" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedandRestrictedStockAwards_2c2906b7-8efa-429d-8748-a0826116ecff" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedandRestrictedStockAwards"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedandRestrictedStockAwards_2c2906b7-8efa-429d-8748-a0826116ecff" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedAndStockOptionsExercised_2901a41c-ad99-4ebe-bb96-ad1ef88ae59f" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedAndStockOptionsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedAndStockOptionsExercised_2901a41c-ad99-4ebe-bb96-ad1ef88ae59f" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwards_8f6a7ace-ecaf-4967-b68a-2b1e32b4e5fe" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwards"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwards_8f6a7ace-ecaf-4967-b68a-2b1e32b4e5fe" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringThePeriodValueAccruedCompensation_45538268-c14b-4186-851a-6e3e75fe7e39" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringThePeriodValueAccruedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringThePeriodValueAccruedCompensation_45538268-c14b-4186-851a-6e3e75fe7e39" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_StockIssuedDuringThePeriodSharesAccruedCompensation_c31c8a81-1e41-4839-9435-5c0bdfc9e53f" xlink:href="pgen-20231231.xsd#pgen_StockIssuedDuringThePeriodSharesAccruedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_StockIssuedDuringThePeriodSharesAccruedCompensation_c31c8a81-1e41-4839-9435-5c0bdfc9e53f" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_720b8fdb-1316-4f06-9734-1c0b9137ecc5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_720b8fdb-1316-4f06-9734-1c0b9137ecc5" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_b3a1a261-21f9-4279-91c5-0f28109fdd72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_b3a1a261-21f9-4279-91c5-0f28109fdd72" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_df4e6dde-8f36-4bfe-9040-4c3bcdaf23a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_df4e6dde-8f36-4bfe-9040-4c3bcdaf23a2" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_e4163d1e-851b-4099-bda1-5d27412b6cea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_e4163d1e-851b-4099-bda1-5d27412b6cea" xlink:type="arc" order="14"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ShareLendingAgreementSharesReturned_662c8273-a493-4700-a108-8a1e649119ab" xlink:href="pgen-20231231.xsd#pgen_ShareLendingAgreementSharesReturned"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_pgen_ShareLendingAgreementSharesReturned_662c8273-a493-4700-a108-8a1e649119ab" xlink:type="arc" order="15"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5acf2555-2fc6-43ed-afc7-2dd9a9dddd11" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_NetIncomeLoss_5acf2555-2fc6-43ed-afc7-2dd9a9dddd11" xlink:type="arc" order="16"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_318b8df7-abe1-484d-b29e-1b6d8eabecf7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_8621b082-bbac-43c6-911d-f086ba2e47ed" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_318b8df7-abe1-484d-b29e-1b6d8eabecf7" xlink:type="arc" order="17"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_b4abb5ec-2091-4ff4-807d-5fe3ab4c0631" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_df71916f-2c8e-46d8-bf17-452b6fb5a87a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_818d135d-3e43-4fbf-9d52-aa5bcae06e7c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdateExtensibleList_ef63fa44-0f51-464d-8270-499df434957c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountingStandardsUpdateExtensibleList"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_dbed6382-dc7a-4968-a654-1dbc5f03146b" xlink:to="loc_us-gaap_AccountingStandardsUpdateExtensibleList_ef63fa44-0f51-464d-8270-499df434957c" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/OrganizationandBasisofPresentationAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#OrganizationandBasisofPresentationAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/OrganizationandBasisofPresentationAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_97b1a28d-aa43-4885-b40e-ffd6b3fc67e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_97b1a28d-aa43-4885-b40e-ffd6b3fc67e3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_f593ef33-ad1a-4fc8-9744-02369c72b264" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_97b1a28d-aa43-4885-b40e-ffd6b3fc67e3" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_f593ef33-ad1a-4fc8-9744-02369c72b264" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_f593ef33-ad1a-4fc8-9744-02369c72b264_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_f593ef33-ad1a-4fc8-9744-02369c72b264" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_f593ef33-ad1a-4fc8-9744-02369c72b264_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_abf9706e-ef8e-431c-9296-db4814c5608b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_f593ef33-ad1a-4fc8-9744-02369c72b264" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_abf9706e-ef8e-431c-9296-db4814c5608b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_4f576ba9-21bb-49e5-abd2-1d2245d6d254" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_abf9706e-ef8e-431c-9296-db4814c5608b" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_4f576ba9-21bb-49e5-abd2-1d2245d6d254" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_1dd8ab6c-c23e-4f14-91ac-778296ec18e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_97b1a28d-aa43-4885-b40e-ffd6b3fc67e3" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_1dd8ab6c-c23e-4f14-91ac-778296ec18e0" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1dd8ab6c-c23e-4f14-91ac-778296ec18e0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_1dd8ab6c-c23e-4f14-91ac-778296ec18e0" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1dd8ab6c-c23e-4f14-91ac-778296ec18e0_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_e6bf39f5-c500-4792-9e87-c0f91e98c001" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_1dd8ab6c-c23e-4f14-91ac-778296ec18e0" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_e6bf39f5-c500-4792-9e87-c0f91e98c001" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_TransOvaMember_a2ef0c88-c32a-4e6f-afa3-e78d79490477" xlink:href="pgen-20231231.xsd#pgen_TransOvaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_e6bf39f5-c500-4792-9e87-c0f91e98c001" xlink:to="loc_pgen_TransOvaMember_a2ef0c88-c32a-4e6f-afa3-e78d79490477" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberOfWhollyOwnedOperatingSubsidiaries_a5641400-0d01-4b6b-a248-fc03a7a973d5" xlink:href="pgen-20231231.xsd#pgen_NumberOfWhollyOwnedOperatingSubsidiaries"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_pgen_NumberOfWhollyOwnedOperatingSubsidiaries_a5641400-0d01-4b6b-a248-fc03a7a973d5" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf_24e74758-c85c-4cd3-b1ae-c5061977ec5d" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf_24e74758-c85c-4cd3-b1ae-c5061977ec5d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_0a01b5be-e541-45c5-b2a1-5f035ee5add8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_us-gaap_NetIncomeLoss_0a01b5be-e541-45c5-b2a1-5f035ee5add8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_31d64cac-b04c-46c7-8e49-0b0686d9a40b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_31d64cac-b04c-46c7-8e49-0b0686d9a40b" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4872148f-dfc0-442b-bc7b-c965977eec8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4872148f-dfc0-442b-bc7b-c965977eec8f" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_3ded4722-5a62-4ff3-b9fc-0767d72264da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_09dcb9fa-9323-4a4f-addf-5bed997a5129" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_3ded4722-5a62-4ff3-b9fc-0767d72264da" xlink:type="arc" order="5"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SummaryofSignificantAccountingPoliciesAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:href="pgen-20231231.xsd#pgen_OrganizationAndSignificantAccountingPoliciesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:href="pgen-20231231.xsd#pgen_SummaryOfSignificantAccountingPoliciesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_srt_ProductOrServiceAxis_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a" xlink:to="loc_srt_ProductsAndServicesDomain_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2f929d1e-7110-4b39-869b-5a484b7ae108" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_9e5e08dd-ffcb-43b5-8304-e4bb2f14e78a" xlink:to="loc_srt_ProductsAndServicesDomain_2f929d1e-7110-4b39-869b-5a484b7ae108" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ProductsandServicesRevenuesMember_a5ba4011-405a-4a6d-940f-0aa2b7fbd53b" xlink:href="pgen-20231231.xsd#pgen_ProductsandServicesRevenuesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2f929d1e-7110-4b39-869b-5a484b7ae108" xlink:to="loc_pgen_ProductsandServicesRevenuesMember_a5ba4011-405a-4a6d-940f-0aa2b7fbd53b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_713c05f8-dfa7-46c5-aa40-88f3d07cc925" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_us-gaap_PlanNameAxis_713c05f8-dfa7-46c5-aa40-88f3d07cc925" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_713c05f8-dfa7-46c5-aa40-88f3d07cc925_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_713c05f8-dfa7-46c5-aa40-88f3d07cc925" xlink:to="loc_us-gaap_PlanNameDomain_713c05f8-dfa7-46c5-aa40-88f3d07cc925_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_cd8020cb-d25f-498a-b6c1-c0329b28220c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_713c05f8-dfa7-46c5-aa40-88f3d07cc925" xlink:to="loc_us-gaap_PlanNameDomain_cd8020cb-d25f-498a-b6c1-c0329b28220c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlansMember_1e7bf2ca-b199-498a-8cd3-66e91ea110c0" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlansMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_cd8020cb-d25f-498a-b6c1-c0329b28220c" xlink:to="loc_pgen_PrecigenStockOptionPlansMember_1e7bf2ca-b199-498a-8cd3-66e91ea110c0" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f035c23b-c317-4d2a-b77b-281eb72041ec" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_srt_RangeAxis_f035c23b-c317-4d2a-b77b-281eb72041ec" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f035c23b-c317-4d2a-b77b-281eb72041ec_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f035c23b-c317-4d2a-b77b-281eb72041ec" xlink:to="loc_srt_RangeMember_f035c23b-c317-4d2a-b77b-281eb72041ec_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e50186f7-1d91-437c-9002-01f253b4efb4" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f035c23b-c317-4d2a-b77b-281eb72041ec" xlink:to="loc_srt_RangeMember_e50186f7-1d91-437c-9002-01f253b4efb4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_bdad3891-caac-4393-adbf-05634dfbd11f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e50186f7-1d91-437c-9002-01f253b4efb4" xlink:to="loc_srt_MinimumMember_bdad3891-caac-4393-adbf-05634dfbd11f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_dd45df1a-3381-4568-9cae-22b3c01a7ef7" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e50186f7-1d91-437c-9002-01f253b4efb4" xlink:to="loc_srt_MaximumMember_dd45df1a-3381-4568-9cae-22b3c01a7ef7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e81370ed-0607-4e5c-9991-2e38f208b8ef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_us-gaap_DebtInstrumentAxis_e81370ed-0607-4e5c-9991-2e38f208b8ef" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e81370ed-0607-4e5c-9991-2e38f208b8ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_e81370ed-0607-4e5c-9991-2e38f208b8ef" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e81370ed-0607-4e5c-9991-2e38f208b8ef_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0fd61b63-009f-4c5b-9d52-4693b142e34b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_e81370ed-0607-4e5c-9991-2e38f208b8ef" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0fd61b63-009f-4c5b-9d52-4693b142e34b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_A3.5ConvertibleNotesDue2023Member_3b802408-1070-4d84-a39a-ed07c9d8e9e5" xlink:href="pgen-20231231.xsd#pgen_A3.5ConvertibleNotesDue2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0fd61b63-009f-4c5b-9d52-4693b142e34b" xlink:to="loc_pgen_A3.5ConvertibleNotesDue2023Member_3b802408-1070-4d84-a39a-ed07c9d8e9e5" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_45d8d2b4-4b80-48bc-8a81-c051f044ac90" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_45d8d2b4-4b80-48bc-8a81-c051f044ac90" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_45d8d2b4-4b80-48bc-8a81-c051f044ac90_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_45d8d2b4-4b80-48bc-8a81-c051f044ac90" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_45d8d2b4-4b80-48bc-8a81-c051f044ac90_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_2d4ead48-e1cb-4dca-ab64-e76924cb07ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_45d8d2b4-4b80-48bc-8a81-c051f044ac90" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_2d4ead48-e1cb-4dca-ab64-e76924cb07ff" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_38b29fc4-1ce7-4943-83b1-7ccbd20661af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_2d4ead48-e1cb-4dca-ab64-e76924cb07ff" xlink:to="loc_us-gaap_ConvertibleDebtMember_38b29fc4-1ce7-4943-83b1-7ccbd20661af" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_df399e36-34ec-4c53-af44-6e7bf27c21d7" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_df399e36-34ec-4c53-af44-6e7bf27c21d7" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_df399e36-34ec-4c53-af44-6e7bf27c21d7_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_df399e36-34ec-4c53-af44-6e7bf27c21d7" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_df399e36-34ec-4c53-af44-6e7bf27c21d7_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_6c016016-3c04-4e94-ad98-ba44a7439db1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_df399e36-34ec-4c53-af44-6e7bf27c21d7" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_6c016016-3c04-4e94-ad98-ba44a7439db1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_86c9512a-264c-406c-a3fb-cad16391195a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_6c016016-3c04-4e94-ad98-ba44a7439db1" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_86c9512a-264c-406c-a3fb-cad16391195a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_d7f5105a-b3bb-40f5-9d39-31fb96ab4658" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_d7f5105a-b3bb-40f5-9d39-31fb96ab4658" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_d7f5105a-b3bb-40f5-9d39-31fb96ab4658_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_d7f5105a-b3bb-40f5-9d39-31fb96ab4658" xlink:to="loc_us-gaap_TypeOfAdoptionMember_d7f5105a-b3bb-40f5-9d39-31fb96ab4658_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_0bfa4f9f-d87a-4daf-98d0-1ca2960d168c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_d7f5105a-b3bb-40f5-9d39-31fb96ab4658" xlink:to="loc_us-gaap_TypeOfAdoptionMember_0bfa4f9f-d87a-4daf-98d0-1ca2960d168c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006RetrospectiveMember_9680d021-02d0-4364-8707-68959d1ced0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountingStandardsUpdate202006RetrospectiveMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_0bfa4f9f-d87a-4daf-98d0-1ca2960d168c" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006RetrospectiveMember_9680d021-02d0-4364-8707-68959d1ced0f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_80e99c74-9945-42c0-b359-89c818688176" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_SummaryOfSignificantAccountingPoliciesTable_850f37f4-4365-483b-9d0e-f1a7908eff55" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_80e99c74-9945-42c0-b359-89c818688176" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_80e99c74-9945-42c0-b359-89c818688176_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_80e99c74-9945-42c0-b359-89c818688176" xlink:to="loc_us-gaap_EquityComponentDomain_80e99c74-9945-42c0-b359-89c818688176_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_1a870d6f-393f-400a-a806-4fb164ed64da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_80e99c74-9945-42c0-b359-89c818688176" xlink:to="loc_us-gaap_EquityComponentDomain_1a870d6f-393f-400a-a806-4fb164ed64da" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_4b45a1e6-42d4-4b30-9c89-665303a8dfa6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_1a870d6f-393f-400a-a806-4fb164ed64da" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_4b45a1e6-42d4-4b30-9c89-665303a8dfa6" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_8b7e77e1-b658-4887-a709-4e82c36be821" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_1a870d6f-393f-400a-a806-4fb164ed64da" xlink:to="loc_us-gaap_RetainedEarningsMember_8b7e77e1-b658-4887-a709-4e82c36be821" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CollaborationAgreementTerminationNoticePeriod_6d293c9f-13d6-458e-a928-0690b3768ca2" xlink:href="pgen-20231231.xsd#pgen_CollaborationAgreementTerminationNoticePeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_pgen_CollaborationAgreementTerminationNoticePeriod_6d293c9f-13d6-458e-a928-0690b3768ca2" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuePerformanceObligationDescriptionOfPaymentTerms_8b313ff0-7827-4a2f-96dc-d31833189df7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenuePerformanceObligationDescriptionOfPaymentTerms"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_RevenuePerformanceObligationDescriptionOfPaymentTerms_8b313ff0-7827-4a2f-96dc-d31833189df7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ResearchAndDevelopmentCommitmentsNotYetIncurred_00646485-d3e5-426e-8897-f726049a9556" xlink:href="pgen-20231231.xsd#pgen_ResearchAndDevelopmentCommitmentsNotYetIncurred"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_pgen_ResearchAndDevelopmentCommitmentsNotYetIncurred_00646485-d3e5-426e-8897-f726049a9556" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_HighlyLiquidInvestmentMaximumMaturityPeriod_ded95792-e57d-4df9-8b66-32fc41ca5cc3" xlink:href="pgen-20231231.xsd#pgen_HighlyLiquidInvestmentMaximumMaturityPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_pgen_HighlyLiquidInvestmentMaximumMaturityPeriod_ded95792-e57d-4df9-8b66-32fc41ca5cc3" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_f666d484-e247-4aa4-b0e1-63b4c7dc70b7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_RestrictedCashCurrent_f666d484-e247-4aa4-b0e1-63b4c7dc70b7" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3da77928-e0bc-4c3c-be81-2db3a8d316d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3da77928-e0bc-4c3c-be81-2db3a8d316d9" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_a26a1ff9-0b70-4db1-8cb6-9ee72e19b073" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_a26a1ff9-0b70-4db1-8cb6-9ee72e19b073" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5921ee83-b15e-4a67-8ea1-cecb387e8164" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5921ee83-b15e-4a67-8ea1-cecb387e8164" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_ac49607f-e23a-4bdd-9684-780303ab1c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_ac49607f-e23a-4bdd-9684-780303ab1c4c" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_c415c609-0b3b-4863-8301-28f7538df119" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_c415c609-0b3b-4863-8301-28f7538df119" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_eb7459d0-3991-41db-af0d-6b9261bbafcc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_eb7459d0-3991-41db-af0d-6b9261bbafcc" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9ee393aa-a28b-4cbe-89e5-a9a6635f7228" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9ee393aa-a28b-4cbe-89e5-a9a6635f7228" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts_1240cfdc-2aad-47ac-ad91-45960dfc793c" xlink:href="pgen-20231231.xsd#pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_OrganizationAndSignificantAccountingPoliciesLineItems_e359ade4-220d-4bc5-a1ab-690a39ceba69" xlink:to="loc_pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts_1240cfdc-2aad-47ac-ad91-45960dfc793c" xlink:type="arc" order="12"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesRollforwardofAllowanceforCreditLossesDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SummaryofSignificantAccountingPoliciesRollforwardofAllowanceforCreditLossesDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesRollforwardofAllowanceforCreditLossesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_AccountsReceivableAllowanceForCreditLossLineItems_47fcb1f4-0c2a-465f-aa87-be4a528b5cb8" xlink:href="pgen-20231231.xsd#pgen_AccountsReceivableAllowanceForCreditLossLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_AccountsReceivableAllowanceForCreditLossTable_d3f9a587-bb8f-49a0-b4d3-f29c9e2f563a" xlink:href="pgen-20231231.xsd#pgen_AccountsReceivableAllowanceForCreditLossTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_AccountsReceivableAllowanceForCreditLossLineItems_47fcb1f4-0c2a-465f-aa87-be4a528b5cb8" xlink:to="loc_pgen_AccountsReceivableAllowanceForCreditLossTable_d3f9a587-bb8f-49a0-b4d3-f29c9e2f563a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_AccountsReceivableAllowanceForCreditLossTable_d3f9a587-bb8f-49a0-b4d3-f29c9e2f563a" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_92440858-7ca0-419d-8aa2-1ed5aa9300da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_d0125d6c-0ca5-48d0-8562-8ac8a7f49a5c" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_92440858-7ca0-419d-8aa2-1ed5aa9300da" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_a0b19ae1-c09b-4e05-a667-0a96302a950c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentContinuingOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_92440858-7ca0-419d-8aa2-1ed5aa9300da" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_a0b19ae1-c09b-4e05-a667-0a96302a950c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_2e5c3a06-872d-4af8-9d2d-a8cb23a89ca1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_AccountsReceivableAllowanceForCreditLossLineItems_47fcb1f4-0c2a-465f-aa87-be4a528b5cb8" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_2e5c3a06-872d-4af8-9d2d-a8cb23a89ca1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_85ca68fc-aefa-4b32-a1cf-54df6b21162d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_2e5c3a06-872d-4af8-9d2d-a8cb23a89ca1" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_85ca68fc-aefa-4b32-a1cf-54df6b21162d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_c4221a75-efdb-4683-95a1-58769a1c9833" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_2e5c3a06-872d-4af8-9d2d-a8cb23a89ca1" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_c4221a75-efdb-4683-95a1-58769a1c9833" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_AccountsReceivableAllowanceForCreditLossWriteoffsNetOfRecoveries_b37c54a5-0684-468c-a9b4-a6ce266604c1" xlink:href="pgen-20231231.xsd#pgen_AccountsReceivableAllowanceForCreditLossWriteoffsNetOfRecoveries"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_2e5c3a06-872d-4af8-9d2d-a8cb23a89ca1" xlink:to="loc_pgen_AccountsReceivableAllowanceForCreditLossWriteoffsNetOfRecoveries_b37c54a5-0684-468c-a9b4-a6ce266604c1" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_66543830-c0d7-4cc6-a4b2-16e0f8e26586" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesofPropertyPlantandEquipmentDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesofPropertyPlantandEquipmentDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_be663873-cecf-4695-8568-98922e69a2cc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_95b839ee-a7f4-4603-a68d-74a4d0b900a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_be663873-cecf-4695-8568-98922e69a2cc" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_95b839ee-a7f4-4603-a68d-74a4d0b900a8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_588455d6-2c7e-4036-a1c8-fb71f7328467" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_95b839ee-a7f4-4603-a68d-74a4d0b900a8" xlink:to="loc_srt_RangeAxis_588455d6-2c7e-4036-a1c8-fb71f7328467" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_588455d6-2c7e-4036-a1c8-fb71f7328467_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_588455d6-2c7e-4036-a1c8-fb71f7328467" xlink:to="loc_srt_RangeMember_588455d6-2c7e-4036-a1c8-fb71f7328467_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_961b66d5-9d71-4782-a5f0-952ebcc69325" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_588455d6-2c7e-4036-a1c8-fb71f7328467" xlink:to="loc_srt_RangeMember_961b66d5-9d71-4782-a5f0-952ebcc69325" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_cd1ffdc9-f71a-456b-a038-37aa25286c87" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_961b66d5-9d71-4782-a5f0-952ebcc69325" xlink:to="loc_srt_MinimumMember_cd1ffdc9-f71a-456b-a038-37aa25286c87" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_b82977cc-075d-455b-82b4-971d3e669075" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_961b66d5-9d71-4782-a5f0-952ebcc69325" xlink:to="loc_srt_MaximumMember_b82977cc-075d-455b-82b4-971d3e669075" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_e84861c8-4789-4cda-ac6d-dd7c95d793ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_95b839ee-a7f4-4603-a68d-74a4d0b900a8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_e84861c8-4789-4cda-ac6d-dd7c95d793ab" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_e84861c8-4789-4cda-ac6d-dd7c95d793ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_e84861c8-4789-4cda-ac6d-dd7c95d793ab" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_e84861c8-4789-4cda-ac6d-dd7c95d793ab_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_e84861c8-4789-4cda-ac6d-dd7c95d793ab" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandImprovementsMember_a348ba1b-5de3-406e-aad3-17e3ef015d2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LandImprovementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_LandImprovementsMember_a348ba1b-5de3-406e-aad3-17e3ef015d2f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_3c9d6a93-5aec-457c-8d61-8428521e3f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_3c9d6a93-5aec-457c-8d61-8428521e3f5d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_944226b5-acff-4c09-b66a-371b21a96ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FurnitureAndFixturesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_944226b5-acff-4c09-b66a-371b21a96ef5" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentMember_7cd6ead0-3fdf-47d5-b54a-4c14a0680943" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquipmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_EquipmentMember_7cd6ead0-3fdf-47d5-b54a-4c14a0680943" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BreedingAndProductionAnimalsMember_d5a1cbfb-a80d-4c24-8234-a0053214ff95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BreedingAndProductionAnimalsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_BreedingAndProductionAnimalsMember_d5a1cbfb-a80d-4c24-8234-a0053214ff95" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ComputerHardwareandSoftwareMember_3c3f7e8d-2b06-4804-aa34-39c8be3348c2" xlink:href="pgen-20231231.xsd#pgen_ComputerHardwareandSoftwareMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_pgen_ComputerHardwareandSoftwareMember_3c3f7e8d-2b06-4804-aa34-39c8be3348c2" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_143670a7-ef3c-4aae-a7a1-42c2c550afd9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseholdImprovementsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_dc9f8b27-f65a-46c7-9842-3a2e6f98e67f" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_143670a7-ef3c-4aae-a7a1-42c2c550afd9" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_2ce35585-e56b-4d94-b244-fe84f0a91acd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_be663873-cecf-4695-8568-98922e69a2cc" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_2ce35585-e56b-4d94-b244-fe84f0a91acd" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesSummaryofAssumptionsUsedinOptionPricingModelDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SummaryofSignificantAccountingPoliciesSummaryofAssumptionsUsedinOptionPricingModelDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesSummaryofAssumptionsUsedinOptionPricingModelDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ad2f62b6-b135-4f1f-942a-09560bed72c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ad2f62b6-b135-4f1f-942a-09560bed72c7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_f8829771-5312-47a8-b352-f9d527b62e88" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ad2f62b6-b135-4f1f-942a-09560bed72c7" xlink:to="loc_us-gaap_PlanNameAxis_f8829771-5312-47a8-b352-f9d527b62e88" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_f8829771-5312-47a8-b352-f9d527b62e88_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_f8829771-5312-47a8-b352-f9d527b62e88" xlink:to="loc_us-gaap_PlanNameDomain_f8829771-5312-47a8-b352-f9d527b62e88_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2b529891-dac7-443a-9b4a-4ad1c1c61ddf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_f8829771-5312-47a8-b352-f9d527b62e88" xlink:to="loc_us-gaap_PlanNameDomain_2b529891-dac7-443a-9b4a-4ad1c1c61ddf" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlansMember_99f67e0c-2b16-4bb4-b792-45a002d3bb07" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlansMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_2b529891-dac7-443a-9b4a-4ad1c1c61ddf" xlink:to="loc_pgen_PrecigenStockOptionPlansMember_99f67e0c-2b16-4bb4-b792-45a002d3bb07" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ad2f62b6-b135-4f1f-942a-09560bed72c7" xlink:to="loc_srt_RangeAxis_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26" xlink:to="loc_srt_RangeMember_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_bca11972-3c42-4d31-b0c5-9e5d94dde761" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_1ae2dd1b-ba6b-46ae-9d24-ba7057d1ae26" xlink:to="loc_srt_RangeMember_bca11972-3c42-4d31-b0c5-9e5d94dde761" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_360ed5a0-8705-43e0-8a4a-b7f321cbd36d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_bca11972-3c42-4d31-b0c5-9e5d94dde761" xlink:to="loc_srt_MinimumMember_360ed5a0-8705-43e0-8a4a-b7f321cbd36d" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_43e0be2f-7317-4d01-bd85-939246949dd9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_bca11972-3c42-4d31-b0c5-9e5d94dde761" xlink:to="loc_srt_MaximumMember_43e0be2f-7317-4d01-bd85-939246949dd9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3dead799-df0d-483a-8c09-fd570d242999" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3dead799-df0d-483a-8c09-fd570d242999" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_f95b8d8d-02ef-4c04-89b1-a042940f7dc6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_f95b8d8d-02ef-4c04-89b1-a042940f7dc6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_726a3600-c9c3-495a-a178-bfdd50c3c8d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_726a3600-c9c3-495a-a178-bfdd50c3c8d4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6ee24f7f-c2f3-4638-ac56-0e38398ca73a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6ee24f7f-c2f3-4638-ac56-0e38398ca73a" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_049f9642-dae8-422a-ac20-1784d1d352e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_049f9642-dae8-422a-ac20-1784d1d352e1" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_bbf0cb67-e367-463c-88b0-d0bb0a1f271e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f6634ed9-72df-4072-9a4e-d42561a4cb51" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_bbf0cb67-e367-463c-88b0-d0bb0a1f271e" xlink:type="arc" order="5"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesPotentiallyDilutiveSecuritiesExcludedfromCalculationofNetLossperShareDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SummaryofSignificantAccountingPoliciesPotentiallyDilutiveSecuritiesExcludedfromCalculationofNetLossperShareDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SummaryofSignificantAccountingPoliciesPotentiallyDilutiveSecuritiesExcludedfromCalculationofNetLossperShareDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_95630213-33ab-49e2-956e-7c2220712fe5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_b79a7ce8-28e4-4d52-a963-f91f026190ae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_95630213-33ab-49e2-956e-7c2220712fe5" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_b79a7ce8-28e4-4d52-a963-f91f026190ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_8c0e8516-aa75-47bf-a350-bc35752f7f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_b79a7ce8-28e4-4d52-a963-f91f026190ae" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_8c0e8516-aa75-47bf-a350-bc35752f7f8e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_8c0e8516-aa75-47bf-a350-bc35752f7f8e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_8c0e8516-aa75-47bf-a350-bc35752f7f8e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_8c0e8516-aa75-47bf-a350-bc35752f7f8e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae8425cd-525c-402f-b94a-f3c17c31743e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_8c0e8516-aa75-47bf-a350-bc35752f7f8e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae8425cd-525c-402f-b94a-f3c17c31743e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockOptionMember_e30507bc-c426-42a1-8090-83228e513bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockOptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae8425cd-525c-402f-b94a-f3c17c31743e" xlink:to="loc_us-gaap_StockOptionMember_e30507bc-c426-42a1-8090-83228e513bd7" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_80bf711f-c32a-47e4-8251-dfadb2873097" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae8425cd-525c-402f-b94a-f3c17c31743e" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_80bf711f-c32a-47e4-8251-dfadb2873097" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_0edc244a-afb3-46c7-abc2-6b7b5e1f1ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WarrantMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae8425cd-525c-402f-b94a-f3c17c31743e" xlink:to="loc_us-gaap_WarrantMember_0edc244a-afb3-46c7-abc2-6b7b5e1f1ca8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_effcd5b6-b0a0-4b2b-bd61-f4fca286e117" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_95630213-33ab-49e2-956e-7c2220712fe5" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_effcd5b6-b0a0-4b2b-bd61-f4fca286e117" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/DiscontinuedOperationsNarrativeDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#DiscontinuedOperationsNarrativeDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/DiscontinuedOperationsNarrativeDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_c08feef6-6c9e-482f-bd7e-7573a0de46b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_c08feef6-6c9e-482f-bd7e-7573a0de46b8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_c08feef6-6c9e-482f-bd7e-7573a0de46b8" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_57e5e2b4-1645-4329-b4f3-e757b88301c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_38b5cb5b-3ab0-4301-9c5c-b0ddde094c43" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_57e5e2b4-1645-4329-b4f3-e757b88301c2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_TransOvaMember_55a284ee-1a6b-454c-a5a6-8f591867ad3b" xlink:href="pgen-20231231.xsd#pgen_TransOvaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_57e5e2b4-1645-4329-b4f3-e757b88301c2" xlink:to="loc_pgen_TransOvaMember_55a284ee-1a6b-454c-a5a6-8f591867ad3b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_MBPTitanMember_dedf87a4-7e7e-4e9c-a375-0e78144165c2" xlink:href="pgen-20231231.xsd#pgen_MBPTitanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_57e5e2b4-1645-4329-b4f3-e757b88301c2" xlink:to="loc_pgen_MBPTitanMember_dedf87a4-7e7e-4e9c-a375-0e78144165c2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_c08feef6-6c9e-482f-bd7e-7573a0de46b8" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_9b1749ef-68cf-48c1-acc4-7761cb1b06e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_46d7bfbd-6364-46a6-8bb7-3c0a7aad36c4" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_9b1749ef-68cf-48c1-acc4-7761cb1b06e0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_c1eb4219-b830-402e-9ead-44f57b7358e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_9b1749ef-68cf-48c1-acc4-7761cb1b06e0" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_c1eb4219-b830-402e-9ead-44f57b7358e3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_3a864711-9db7-4c81-915e-ddaa98fe1cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_9b1749ef-68cf-48c1-acc4-7761cb1b06e0" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_3a864711-9db7-4c81-915e-ddaa98fe1cd6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_c08feef6-6c9e-482f-bd7e-7573a0de46b8" xlink:to="loc_srt_RangeAxis_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1" xlink:to="loc_srt_RangeMember_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3db0054f-bc74-4e59-8f73-dd04acdb664c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_ed5f82a4-ebc3-4ee4-bb50-ea138ba914b1" xlink:to="loc_srt_RangeMember_3db0054f-bc74-4e59-8f73-dd04acdb664c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_1946ab9b-7222-4dcf-a4bc-eb93c499bd1a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_3db0054f-bc74-4e59-8f73-dd04acdb664c" xlink:to="loc_srt_MaximumMember_1946ab9b-7222-4dcf-a4bc-eb93c499bd1a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf_8b64a175-54b9-4441-b3e0-e57e18a02cc8" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf_8b64a175-54b9-4441-b3e0-e57e18a02cc8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_a3d32868-b660-4ff6-bca3-56e238d79dbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_a3d32868-b660-4ff6-bca3-56e238d79dbb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPaymentsRangeOfOutcomesValueHigh_bd416c6e-3738-4980-8f09-79686f5e10b5" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPaymentsRangeOfOutcomesValueHigh"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPaymentsRangeOfOutcomesValueHigh_bd416c6e-3738-4980-8f09-79686f5e10b5" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPayments_4579e0fc-ab53-4251-9150-e300c450fdbb" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPayments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPayments_4579e0fc-ab53-4251-9150-e300c450fdbb" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_8fbbba11-b94d-4246-b3e8-be61afc7aeff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_8fbbba11-b94d-4246-b3e8-be61afc7aeff" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationReimbursementLimit_8f08a3ec-310c-45c9-a5f2-a63cf1e78c3d" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationReimbursementLimit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationReimbursementLimit_8f08a3ec-310c-45c9-a5f2-a63cf1e78c3d" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationIndemnificationLiability_c0145ed5-9d10-4c85-abb9-3a2a15d77dce" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationIndemnificationLiability"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationIndemnificationLiability_c0145ed5-9d10-4c85-abb9-3a2a15d77dce" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IncreaseDecreaseSettlementAndIdentificationAccruals_05f56e39-6447-4c92-97af-c54297cf4031" xlink:href="pgen-20231231.xsd#pgen_IncreaseDecreaseSettlementAndIdentificationAccruals"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_pgen_IncreaseDecreaseSettlementAndIdentificationAccruals_05f56e39-6447-4c92-97af-c54297cf4031" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_03831791-ce53-43b2-bb5f-a82dc3331f05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_03831791-ce53-43b2-bb5f-a82dc3331f05" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnTerminationOfLease_a642dc18-2f9c-489d-b4eb-18f679381a2c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnTerminationOfLease"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_7af0f41a-639f-4582-94a8-f7cf8f52d38a" xlink:to="loc_us-gaap_GainLossOnTerminationOfLease_a642dc18-2f9c-489d-b4eb-18f679381a2c" xlink:type="arc" order="9"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/DiscontinuedOperationsSummaryofFinancialResultsforTransOvaDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#DiscontinuedOperationsSummaryofFinancialResultsforTransOvaDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/DiscontinuedOperationsSummaryofFinancialResultsforTransOvaDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f1efbbf3-fdb3-468d-888e-fdb7363c944c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f1efbbf3-fdb3-468d-888e-fdb7363c944c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_6693bdb6-8d8b-432e-93fe-59d131ec819a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f1efbbf3-fdb3-468d-888e-fdb7363c944c" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_6693bdb6-8d8b-432e-93fe-59d131ec819a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_6693bdb6-8d8b-432e-93fe-59d131ec819a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_6693bdb6-8d8b-432e-93fe-59d131ec819a" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_6693bdb6-8d8b-432e-93fe-59d131ec819a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1e10d309-547b-40a9-ac3e-a044334e7bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_6693bdb6-8d8b-432e-93fe-59d131ec819a" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1e10d309-547b-40a9-ac3e-a044334e7bb1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_TransOvaMember_0ab76199-16ad-432a-92a8-85d836f7cdfa" xlink:href="pgen-20231231.xsd#pgen_TransOvaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1e10d309-547b-40a9-ac3e-a044334e7bb1" xlink:to="loc_pgen_TransOvaMember_0ab76199-16ad-432a-92a8-85d836f7cdfa" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_fda2404b-6be2-4843-92ab-5f3f3b492e00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f1efbbf3-fdb3-468d-888e-fdb7363c944c" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_fda2404b-6be2-4843-92ab-5f3f3b492e00" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_fda2404b-6be2-4843-92ab-5f3f3b492e00_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_fda2404b-6be2-4843-92ab-5f3f3b492e00" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_fda2404b-6be2-4843-92ab-5f3f3b492e00_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_062f9774-7009-46aa-9e9b-331e525fa325" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_fda2404b-6be2-4843-92ab-5f3f3b492e00" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_062f9774-7009-46aa-9e9b-331e525fa325" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_40e94cee-0656-442b-824e-fec2094ce3b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_062f9774-7009-46aa-9e9b-331e525fa325" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_40e94cee-0656-442b-824e-fec2094ce3b8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_2bc8b208-f981-45b4-b5fc-6a38788be840" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f1efbbf3-fdb3-468d-888e-fdb7363c944c" xlink:to="loc_srt_ProductOrServiceAxis_2bc8b208-f981-45b4-b5fc-6a38788be840" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2bc8b208-f981-45b4-b5fc-6a38788be840_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_2bc8b208-f981-45b4-b5fc-6a38788be840" xlink:to="loc_srt_ProductsAndServicesDomain_2bc8b208-f981-45b4-b5fc-6a38788be840_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_008e2498-d6cd-4ec5-8370-a949a3af992f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_2bc8b208-f981-45b4-b5fc-6a38788be840" xlink:to="loc_srt_ProductsAndServicesDomain_008e2498-d6cd-4ec5-8370-a949a3af992f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_5b4f41ea-c1f6-4526-9220-38741745147a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_008e2498-d6cd-4ec5-8370-a949a3af992f" xlink:to="loc_us-gaap_ProductMember_5b4f41ea-c1f6-4526-9220-38741745147a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServiceMember_3cbd7797-1c80-4109-a65f-e46e2ef2449e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ServiceMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_008e2498-d6cd-4ec5-8370-a949a3af992f" xlink:to="loc_us-gaap_ServiceMember_3cbd7797-1c80-4109-a65f-e46e2ef2449e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_3dc59aed-fba3-4a10-a4f1-551f4a07292f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_3dc59aed-fba3-4a10-a4f1-551f4a07292f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold_53d3d00c-ca3c-497a-ac82-bfb680a0a0a1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold_53d3d00c-ca3c-497a-ac82-bfb680a0a0a1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationCostsOfServices_01682fb7-25c6-4957-8e00-2400b021627a" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationCostsOfServices"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationCostsOfServices_01682fb7-25c6-4957-8e00-2400b021627a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopment_566d7c36-9684-48bf-a1e1-850486f6212e" xlink:href="pgen-20231231.xsd#pgen_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_pgen_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopment_566d7c36-9684-48bf-a1e1-850486f6212e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense_46de9e50-ad64-4cfc-a398-cb3b0ad18d13" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense_46de9e50-ad64-4cfc-a398-cb3b0ad18d13" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_0a79a104-8776-4add-ae5f-147463b77d31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_0a79a104-8776-4add-ae5f-147463b77d31" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_6e582028-f050-403f-a06e-e17d5a8b0555" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_6e582028-f050-403f-a06e-e17d5a8b0555" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome_e165466a-adb3-4089-8a91-73a7d3008e68" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome_e165466a-adb3-4089-8a91-73a7d3008e68" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_4f29419d-c744-4fd1-9115-12a81e75c8c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_4f29419d-c744-4fd1-9115-12a81e75c8c2" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_d5cdba28-2dc1-4a8c-b53a-6a588ed33e08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_d5cdba28-2dc1-4a8c-b53a-6a588ed33e08" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_7fa59cc6-5575-44d4-aa86-22f5fe4a564e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_7fa59cc6-5575-44d4-aa86-22f5fe4a564e" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_8b0cb6bc-9db6-4824-a6ca-f64d5cadf617" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_67e1fdfe-5f08-45c8-94eb-d2a51707e5b6" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_8b0cb6bc-9db6-4824-a6ca-f64d5cadf617" xlink:type="arc" order="11"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/DiscontinuedOperationsSummaryofSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsTransOvaDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#DiscontinuedOperationsSummaryofSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsTransOvaDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/DiscontinuedOperationsSummaryofSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsTransOvaDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_0f20cfb2-0847-4c8d-ad99-26be9f95decf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f451f537-1df0-43f1-b755-ea0b06069f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_0f20cfb2-0847-4c8d-ad99-26be9f95decf" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f451f537-1df0-43f1-b755-ea0b06069f1d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_28391a96-d223-491a-b48f-0476b8175392" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f451f537-1df0-43f1-b755-ea0b06069f1d" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_28391a96-d223-491a-b48f-0476b8175392" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_28391a96-d223-491a-b48f-0476b8175392_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_28391a96-d223-491a-b48f-0476b8175392" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_28391a96-d223-491a-b48f-0476b8175392_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_acf21490-bb58-46f9-b5ad-b42b533a4fcb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_28391a96-d223-491a-b48f-0476b8175392" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_acf21490-bb58-46f9-b5ad-b42b533a4fcb" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_TransOvaMember_3dc4d7bb-4105-420c-a7e2-e869311b7f84" xlink:href="pgen-20231231.xsd#pgen_TransOvaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_acf21490-bb58-46f9-b5ad-b42b533a4fcb" xlink:to="loc_pgen_TransOvaMember_3dc4d7bb-4105-420c-a7e2-e869311b7f84" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_9e7c3e9a-dcd8-441c-85e1-e6897f0af706" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f451f537-1df0-43f1-b755-ea0b06069f1d" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_9e7c3e9a-dcd8-441c-85e1-e6897f0af706" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_9e7c3e9a-dcd8-441c-85e1-e6897f0af706_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_9e7c3e9a-dcd8-441c-85e1-e6897f0af706" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_9e7c3e9a-dcd8-441c-85e1-e6897f0af706_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_45fda1a5-71b6-45e5-950c-27c3d9e1cc4e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_9e7c3e9a-dcd8-441c-85e1-e6897f0af706" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_45fda1a5-71b6-45e5-950c-27c3d9e1cc4e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_cf1ca960-f6d9-4ed2-a8f0-574c9504eff8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_45fda1a5-71b6-45e5-950c-27c3d9e1cc4e" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_cf1ca960-f6d9-4ed2-a8f0-574c9504eff8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_0f20cfb2-0847-4c8d-ad99-26be9f95decf" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_f1f0c010-e3fc-4400-8b89-173bc21c5f15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_f1f0c010-e3fc-4400-8b89-173bc21c5f15" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_5acb3c0c-02fe-4890-8d71-1b59ba381685" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_AssetImpairmentCharges_5acb3c0c-02fe-4890-8d71-1b59ba381685" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_eec9a1e1-6d14-4253-8f30-82db6d0ad440" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_eec9a1e1-6d14-4253-8f30-82db6d0ad440" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d1591382-57ea-43d2-b881-dd4f508d098e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d1591382-57ea-43d2-b881-dd4f508d098e" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_17364369-8b4b-4bff-a129-08b072739f4e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_17364369-8b4b-4bff-a129-08b072739f4e" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_4a17e233-c82a-4aad-8a96-e413543000d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_8f6d6a26-618e-49a0-b9c5-9716e4372225" xlink:to="loc_us-gaap_ShareBasedCompensation_4a17e233-c82a-4aad-8a96-e413543000d2" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_d08fdb3e-1c9a-4c3f-83ac-b78593b6f729" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_0f20cfb2-0847-4c8d-ad99-26be9f95decf" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_d08fdb3e-1c9a-4c3f-83ac-b78593b6f729" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_1c4a1670-4883-4d5f-b706-fc73ca5089e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_d08fdb3e-1c9a-4c3f-83ac-b78593b6f729" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_1c4a1670-4883-4d5f-b706-fc73ca5089e1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_81679a48-a799-4685-9637-f0cd46699372" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_d08fdb3e-1c9a-4c3f-83ac-b78593b6f729" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_81679a48-a799-4685-9637-f0cd46699372" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_2ff85cae-9613-4f9b-aa23-299b8a575e10" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_d08fdb3e-1c9a-4c3f-83ac-b78593b6f729" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_2ff85cae-9613-4f9b-aa23-299b8a575e10" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/DiscontinuedOperationsSummaryofFinancialResultsforMBPTitanDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#DiscontinuedOperationsSummaryofFinancialResultsforMBPTitanDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/DiscontinuedOperationsSummaryofFinancialResultsforMBPTitanDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5abc0e52-32b2-4c23-a36a-4f5f8c388085" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5abc0e52-32b2-4c23-a36a-4f5f8c388085" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_623ea60d-1f0c-4a75-a360-d18300840105" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5abc0e52-32b2-4c23-a36a-4f5f8c388085" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_623ea60d-1f0c-4a75-a360-d18300840105" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_623ea60d-1f0c-4a75-a360-d18300840105_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_623ea60d-1f0c-4a75-a360-d18300840105" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_623ea60d-1f0c-4a75-a360-d18300840105_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f669f55e-4340-4f04-9125-2765d0af9431" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_623ea60d-1f0c-4a75-a360-d18300840105" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f669f55e-4340-4f04-9125-2765d0af9431" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_MBPTitanMember_2fbf3f99-fc36-4a33-9436-2c2fbf17398b" xlink:href="pgen-20231231.xsd#pgen_MBPTitanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f669f55e-4340-4f04-9125-2765d0af9431" xlink:to="loc_pgen_MBPTitanMember_2fbf3f99-fc36-4a33-9436-2c2fbf17398b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_a6ac00e3-da0c-425e-985a-e374586f0561" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5abc0e52-32b2-4c23-a36a-4f5f8c388085" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_a6ac00e3-da0c-425e-985a-e374586f0561" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_a6ac00e3-da0c-425e-985a-e374586f0561_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_a6ac00e3-da0c-425e-985a-e374586f0561" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_a6ac00e3-da0c-425e-985a-e374586f0561_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_f779a138-8514-43ee-9087-9b5ac546de45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_a6ac00e3-da0c-425e-985a-e374586f0561" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_f779a138-8514-43ee-9087-9b5ac546de45" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_0f0f1eb7-292d-47e7-a3b5-03c46411cbf4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_f779a138-8514-43ee-9087-9b5ac546de45" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_0f0f1eb7-292d-47e7-a3b5-03c46411cbf4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_90a98178-2429-4e0e-80aa-1e06738a48ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_90a98178-2429-4e0e-80aa-1e06738a48ff" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_599c3b58-b2bf-491b-8f9b-a5bd05d9a328" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_599c3b58-b2bf-491b-8f9b-a5bd05d9a328" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_652e3b63-8e14-4884-8312-6978d19856d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_652e3b63-8e14-4884-8312-6978d19856d3" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_750f2d0e-4ac1-459c-924b-cb145401a4ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_401ea3aa-3d35-4aae-8754-e1bd379ff5b9" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_750f2d0e-4ac1-459c-924b-cb145401a4ed" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/DiscontinuedOperationsSummaryOfSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsMBPTitanDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#DiscontinuedOperationsSummaryOfSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsMBPTitanDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/DiscontinuedOperationsSummaryOfSignificantNonCashItemsInvestmentsandPurchasesofPropertyPlantandEquipmentonCashFlowsMBPTitanDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_f505791c-f88f-4375-a898-fa0a423644f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_09baabf4-bd04-429e-a014-552f69b4e594" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_f505791c-f88f-4375-a898-fa0a423644f4" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_09baabf4-bd04-429e-a014-552f69b4e594" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_8984c802-2278-4029-88cb-4adb2d3d8240" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_09baabf4-bd04-429e-a014-552f69b4e594" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_8984c802-2278-4029-88cb-4adb2d3d8240" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_8984c802-2278-4029-88cb-4adb2d3d8240_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_8984c802-2278-4029-88cb-4adb2d3d8240" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_8984c802-2278-4029-88cb-4adb2d3d8240_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_7049f8ee-55a4-4905-8441-5c3dbe7d58c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_8984c802-2278-4029-88cb-4adb2d3d8240" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_7049f8ee-55a4-4905-8441-5c3dbe7d58c2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_MBPTitanMember_42e085b8-64bb-4e51-a4ab-313e40c9e379" xlink:href="pgen-20231231.xsd#pgen_MBPTitanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_7049f8ee-55a4-4905-8441-5c3dbe7d58c2" xlink:to="loc_pgen_MBPTitanMember_42e085b8-64bb-4e51-a4ab-313e40c9e379" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_97222168-5b78-46bc-85c2-205a0f91070a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_09baabf4-bd04-429e-a014-552f69b4e594" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_97222168-5b78-46bc-85c2-205a0f91070a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_97222168-5b78-46bc-85c2-205a0f91070a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_97222168-5b78-46bc-85c2-205a0f91070a" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_97222168-5b78-46bc-85c2-205a0f91070a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_cd944e8e-f7c6-4895-b8f9-bd021482fb27" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_97222168-5b78-46bc-85c2-205a0f91070a" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_cd944e8e-f7c6-4895-b8f9-bd021482fb27" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_d97039e0-d391-49e6-8bf1-f5c5654c879e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_cd944e8e-f7c6-4895-b8f9-bd021482fb27" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_d97039e0-d391-49e6-8bf1-f5c5654c879e" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_3bac588c-9c0b-45d9-bc70-7bc631cc8b60" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_f505791c-f88f-4375-a898-fa0a423644f4" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_3bac588c-9c0b-45d9-bc70-7bc631cc8b60" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NoncashGainLossOnTerminationOfLease_6b56c41a-0066-4635-9712-414d6508602d" xlink:href="pgen-20231231.xsd#pgen_NoncashGainLossOnTerminationOfLease"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_f505791c-f88f-4375-a898-fa0a423644f4" xlink:to="loc_pgen_NoncashGainLossOnTerminationOfLease_6b56c41a-0066-4635-9712-414d6508602d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfOtherAssetsInvestingActivities_c35b17b3-5727-4afa-8c3f-46699e61287e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfOtherAssetsInvestingActivities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_f505791c-f88f-4375-a898-fa0a423644f4" xlink:to="loc_us-gaap_ProceedsFromSaleOfOtherAssetsInvestingActivities_c35b17b3-5727-4afa-8c3f-46699e61287e" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/InvestmentsinJointVenturesIntrexonEnergyPartnersAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#InvestmentsinJointVenturesIntrexonEnergyPartnersAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/InvestmentsinJointVenturesIntrexonEnergyPartnersAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:href="pgen-20231231.xsd#pgen_ScheduleOfInvestmentsInJointVentureLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:href="pgen-20231231.xsd#pgen_ScheduleOfInvestmentsInJointVentureTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_35f9511e-35d7-47e8-b7bc-ca869b7da41d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:to="loc_srt_CounterpartyNameAxis_35f9511e-35d7-47e8-b7bc-ca869b7da41d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_35f9511e-35d7-47e8-b7bc-ca869b7da41d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_35f9511e-35d7-47e8-b7bc-ca869b7da41d" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_35f9511e-35d7-47e8-b7bc-ca869b7da41d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4a0dca14-8e84-4390-a707-855ca02f39be" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_35f9511e-35d7-47e8-b7bc-ca869b7da41d" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4a0dca14-8e84-4390-a707-855ca02f39be" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersMember_21fe9839-4639-4ebb-8b58-8200404a39d1" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4a0dca14-8e84-4390-a707-855ca02f39be" xlink:to="loc_pgen_IntrexonEnergyPartnersMember_21fe9839-4639-4ebb-8b58-8200404a39d1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_36b3fdcc-9799-435d-99d7-caf10d4bb52e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_36b3fdcc-9799-435d-99d7-caf10d4bb52e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_36b3fdcc-9799-435d-99d7-caf10d4bb52e_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_36b3fdcc-9799-435d-99d7-caf10d4bb52e" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_36b3fdcc-9799-435d-99d7-caf10d4bb52e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_eabed6a3-6a3e-459e-be98-fe372aa119ef" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_36b3fdcc-9799-435d-99d7-caf10d4bb52e" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_eabed6a3-6a3e-459e-be98-fe372aa119ef" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersMember_878bdb23-21d9-430d-96f8-db0761cbbeaa" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_eabed6a3-6a3e-459e-be98-fe372aa119ef" xlink:to="loc_pgen_IntrexonEnergyPartnersMember_878bdb23-21d9-430d-96f8-db0761cbbeaa" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_a2bbc9dc-d379-4c50-8669-60e1a8cc815a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:to="loc_us-gaap_TypeOfArrangementAxis_a2bbc9dc-d379-4c50-8669-60e1a8cc815a" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a2bbc9dc-d379-4c50-8669-60e1a8cc815a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a2bbc9dc-d379-4c50-8669-60e1a8cc815a" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a2bbc9dc-d379-4c50-8669-60e1a8cc815a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4eb98c2d-ec1a-4736-b569-6b58abeadfb3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a2bbc9dc-d379-4c50-8669-60e1a8cc815a" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4eb98c2d-ec1a-4736-b569-6b58abeadfb3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_b5b51183-5b64-4da2-8e54-909c63f43e26" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4eb98c2d-ec1a-4736-b569-6b58abeadfb3" xlink:to="loc_us-gaap_CollaborativeArrangementMember_b5b51183-5b64-4da2-8e54-909c63f43e26" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_7127fef0-5779-40a2-89dc-b920a36f410e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:to="loc_srt_OwnershipAxis_7127fef0-5779-40a2-89dc-b920a36f410e" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_7127fef0-5779-40a2-89dc-b920a36f410e_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_7127fef0-5779-40a2-89dc-b920a36f410e" xlink:to="loc_srt_OwnershipDomain_7127fef0-5779-40a2-89dc-b920a36f410e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_c026a667-6ae6-47c5-ab45-ed6b43f82da0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_7127fef0-5779-40a2-89dc-b920a36f410e" xlink:to="loc_srt_OwnershipDomain_c026a667-6ae6-47c5-ab45-ed6b43f82da0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersMember_c5413aac-a5d7-48d6-a87e-7f05af1733bb" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_c026a667-6ae6-47c5-ab45-ed6b43f82da0" xlink:to="loc_pgen_IntrexonEnergyPartnersMember_c5413aac-a5d7-48d6-a87e-7f05af1733bb" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_8770eb8c-0fe6-4b2a-90d0-3a210f965123" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_fcd9eec1-b7b4-4bb3-90b2-112bb79aa7b1" xlink:to="loc_dei_LegalEntityAxis_8770eb8c-0fe6-4b2a-90d0-3a210f965123" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8770eb8c-0fe6-4b2a-90d0-3a210f965123_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_8770eb8c-0fe6-4b2a-90d0-3a210f965123" xlink:to="loc_dei_EntityDomain_8770eb8c-0fe6-4b2a-90d0-3a210f965123_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_2ce14b20-7255-448d-8423-19f720721bb3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_8770eb8c-0fe6-4b2a-90d0-3a210f965123" xlink:to="loc_dei_EntityDomain_2ce14b20-7255-448d-8423-19f720721bb3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenAndRemainingIEPInvestorsMember_ea0f4188-b68a-4370-b79d-409a80a3bd86" xlink:href="pgen-20231231.xsd#pgen_PrecigenAndRemainingIEPInvestorsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_2ce14b20-7255-448d-8423-19f720721bb3" xlink:to="loc_pgen_PrecigenAndRemainingIEPInvestorsMember_ea0f4188-b68a-4370-b79d-409a80a3bd86" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CollaborativeArrangementConsiderationReceivedValue_ad47e01a-2758-432a-a7bc-e8471274cdf9" xlink:href="pgen-20231231.xsd#pgen_CollaborativeArrangementConsiderationReceivedValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_pgen_CollaborativeArrangementConsiderationReceivedValue_ad47e01a-2758-432a-a7bc-e8471274cdf9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_a5452a80-0889-465a-85a5-e3ec85f7d41a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_a5452a80-0889-465a-85a5-e3ec85f7d41a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoard_624886c0-49b9-4cfb-8a99-e1d1372d6a08" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoard"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_pgen_NumberofSeatsonGoverningBoard_624886c0-49b9-4cfb-8a99-e1d1372d6a08" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoardInternallySelected_96f0f26c-a6b2-49b0-a830-9217dd8880d3" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoardInternallySelected"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_pgen_NumberofSeatsonGoverningBoardInternallySelected_96f0f26c-a6b2-49b0-a830-9217dd8880d3" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoardExternallySelected_053aca83-003d-4793-92b2-8c778b070ccc" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoardExternallySelected"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_pgen_NumberofSeatsonGoverningBoardExternallySelected_053aca83-003d-4793-92b2-8c778b070ccc" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_501074df-e890-44bd-9737-9cbcd93e80d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_a950c5b2-f7c7-4c24-aae2-8aec47b00857" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_501074df-e890-44bd-9737-9cbcd93e80d3" xlink:type="arc" order="5"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/InvestmentsinJointVenturesIntrexonEnergyPartnersIIAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#InvestmentsinJointVenturesIntrexonEnergyPartnersIIAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/InvestmentsinJointVenturesIntrexonEnergyPartnersIIAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:href="pgen-20231231.xsd#pgen_ScheduleOfInvestmentsInJointVentureLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:href="pgen-20231231.xsd#pgen_ScheduleOfInvestmentsInJointVentureTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_6f01df2f-9874-4cfe-b9c8-32a726b58607" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:to="loc_srt_CounterpartyNameAxis_6f01df2f-9874-4cfe-b9c8-32a726b58607" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_6f01df2f-9874-4cfe-b9c8-32a726b58607_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_6f01df2f-9874-4cfe-b9c8-32a726b58607" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_6f01df2f-9874-4cfe-b9c8-32a726b58607_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a085c3b9-466f-445b-a316-e9b4989612ee" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_6f01df2f-9874-4cfe-b9c8-32a726b58607" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a085c3b9-466f-445b-a316-e9b4989612ee" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersIILLCMember_a8bfe8a7-2435-48e1-ae41-04a66c254589" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersIILLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a085c3b9-466f-445b-a316-e9b4989612ee" xlink:to="loc_pgen_IntrexonEnergyPartnersIILLCMember_a8bfe8a7-2435-48e1-ae41-04a66c254589" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_76a5d29f-d521-4da6-8e97-e28ee978d05d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_76a5d29f-d521-4da6-8e97-e28ee978d05d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_76a5d29f-d521-4da6-8e97-e28ee978d05d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_76a5d29f-d521-4da6-8e97-e28ee978d05d" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_76a5d29f-d521-4da6-8e97-e28ee978d05d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_b86f101c-00c1-4c7e-8e12-8e84933c5b06" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_76a5d29f-d521-4da6-8e97-e28ee978d05d" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_b86f101c-00c1-4c7e-8e12-8e84933c5b06" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersIILLCMember_c750c872-c7b8-484c-aafc-808c4cc30fb9" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersIILLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_b86f101c-00c1-4c7e-8e12-8e84933c5b06" xlink:to="loc_pgen_IntrexonEnergyPartnersIILLCMember_c750c872-c7b8-484c-aafc-808c4cc30fb9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_87b49693-a4cc-41ee-9775-a9fb44686ed2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:to="loc_us-gaap_TypeOfArrangementAxis_87b49693-a4cc-41ee-9775-a9fb44686ed2" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_87b49693-a4cc-41ee-9775-a9fb44686ed2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_87b49693-a4cc-41ee-9775-a9fb44686ed2" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_87b49693-a4cc-41ee-9775-a9fb44686ed2_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_81b168cc-6bb8-4ba1-9d56-fae14cb31ecc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_87b49693-a4cc-41ee-9775-a9fb44686ed2" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_81b168cc-6bb8-4ba1-9d56-fae14cb31ecc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_c18aba53-0649-4b30-b199-3a8566d54b4a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_81b168cc-6bb8-4ba1-9d56-fae14cb31ecc" xlink:to="loc_us-gaap_CollaborativeArrangementMember_c18aba53-0649-4b30-b199-3a8566d54b4a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_0d620197-f21d-4d0c-83e4-b109b31a45a4" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:to="loc_srt_OwnershipAxis_0d620197-f21d-4d0c-83e4-b109b31a45a4" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_0d620197-f21d-4d0c-83e4-b109b31a45a4_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_0d620197-f21d-4d0c-83e4-b109b31a45a4" xlink:to="loc_srt_OwnershipDomain_0d620197-f21d-4d0c-83e4-b109b31a45a4_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_57884671-db09-40ef-9a08-6fec0a16c40b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_0d620197-f21d-4d0c-83e4-b109b31a45a4" xlink:to="loc_srt_OwnershipDomain_57884671-db09-40ef-9a08-6fec0a16c40b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersIILLCMember_f4da18b5-a0aa-486b-b472-7f4f33eb6346" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersIILLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_57884671-db09-40ef-9a08-6fec0a16c40b" xlink:to="loc_pgen_IntrexonEnergyPartnersIILLCMember_f4da18b5-a0aa-486b-b472-7f4f33eb6346" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_69b447b2-609a-4724-b406-1e9904e52dec" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureTable_403675d1-a5e0-426e-af9e-b6fe812268a7" xlink:to="loc_dei_LegalEntityAxis_69b447b2-609a-4724-b406-1e9904e52dec" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_69b447b2-609a-4724-b406-1e9904e52dec_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_69b447b2-609a-4724-b406-1e9904e52dec" xlink:to="loc_dei_EntityDomain_69b447b2-609a-4724-b406-1e9904e52dec_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_6bf33026-147e-46aa-b6e1-d3c1b29dc327" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_69b447b2-609a-4724-b406-1e9904e52dec" xlink:to="loc_dei_EntityDomain_6bf33026-147e-46aa-b6e1-d3c1b29dc327" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenAndRemainingIEPInvestorsMember_27529b68-7e3f-494c-bc9d-de7f530e9d23" xlink:href="pgen-20231231.xsd#pgen_PrecigenAndRemainingIEPInvestorsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6bf33026-147e-46aa-b6e1-d3c1b29dc327" xlink:to="loc_pgen_PrecigenAndRemainingIEPInvestorsMember_27529b68-7e3f-494c-bc9d-de7f530e9d23" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CollaborativeArrangementConsiderationReceivedValue_d5d84854-0982-4a7c-ba2f-48297152c30a" xlink:href="pgen-20231231.xsd#pgen_CollaborativeArrangementConsiderationReceivedValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_pgen_CollaborativeArrangementConsiderationReceivedValue_d5d84854-0982-4a7c-ba2f-48297152c30a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_01464ae2-b2ba-4fdd-a0e3-d40adfd8c2bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_01464ae2-b2ba-4fdd-a0e3-d40adfd8c2bd" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoard_2915600d-285a-42a7-9336-ab2fdbf8c0a8" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoard"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_pgen_NumberofSeatsonGoverningBoard_2915600d-285a-42a7-9336-ab2fdbf8c0a8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoardInternallySelected_e86a2ed5-53df-4ab7-8af7-974fbc864cea" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoardInternallySelected"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_pgen_NumberofSeatsonGoverningBoardInternallySelected_e86a2ed5-53df-4ab7-8af7-974fbc864cea" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberofSeatsonGoverningBoardExternallySelected_a8770a8c-3b15-4b94-bdbc-7b1cf64fba2a" xlink:href="pgen-20231231.xsd#pgen_NumberofSeatsonGoverningBoardExternallySelected"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_pgen_NumberofSeatsonGoverningBoardExternallySelected_a8770a8c-3b15-4b94-bdbc-7b1cf64fba2a" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_50c3aca2-5b17-4f92-9219-6d771a25df5b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_ScheduleOfInvestmentsInJointVentureLineItems_e620b8b8-e430-4396-a5df-85aee5eec4a5" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_50c3aca2-5b17-4f92-9219-6d771a25df5b" xlink:type="arc" order="5"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/InvestmentsinJointVenturesInterestsinIntrexonEnergyPartnersandIntrexonEnergyPartnersIIDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#InvestmentsinJointVenturesInterestsinIntrexonEnergyPartnersandIntrexonEnergyPartnersIIDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/InvestmentsinJointVenturesInterestsinIntrexonEnergyPartnersandIntrexonEnergyPartnersIIDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_a3871bf8-ab0b-4f02-b528-f6782aa3a699" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_47f97fb4-22c9-4ee1-b9c1-337cba04ead5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_a3871bf8-ab0b-4f02-b528-f6782aa3a699" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_47f97fb4-22c9-4ee1-b9c1-337cba04ead5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_9a3aa22f-3adb-49f1-9898-2e83469ebb2e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_47f97fb4-22c9-4ee1-b9c1-337cba04ead5" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_9a3aa22f-3adb-49f1-9898-2e83469ebb2e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_9a3aa22f-3adb-49f1-9898-2e83469ebb2e_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_9a3aa22f-3adb-49f1-9898-2e83469ebb2e" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_9a3aa22f-3adb-49f1-9898-2e83469ebb2e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_26dedd59-f426-46cc-9606-784cc8053239" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_9a3aa22f-3adb-49f1-9898-2e83469ebb2e" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_26dedd59-f426-46cc-9606-784cc8053239" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_f4964a10-0c9d-4404-9fb3-10ce976cdf25" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_26dedd59-f426-46cc-9606-784cc8053239" xlink:to="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_f4964a10-0c9d-4404-9fb3-10ce976cdf25" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis_30b06619-830f-4a78-9ffb-8bce02f312e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_47f97fb4-22c9-4ee1-b9c1-337cba04ead5" xlink:to="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis_30b06619-830f-4a78-9ffb-8bce02f312e3" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain_30b06619-830f-4a78-9ffb-8bce02f312e3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis_30b06619-830f-4a78-9ffb-8bce02f312e3" xlink:to="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain_30b06619-830f-4a78-9ffb-8bce02f312e3_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain_0dc105a4-3555-498e-9c63-cd8669ecfa2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis_30b06619-830f-4a78-9ffb-8bce02f312e3" xlink:to="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain_0dc105a4-3555-498e-9c63-cd8669ecfa2f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_fa6ebe1b-2c3e-4827-899e-2d3beb3ea56a" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain_0dc105a4-3555-498e-9c63-cd8669ecfa2f" xlink:to="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_fa6ebe1b-2c3e-4827-899e-2d3beb3ea56a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_662c3a15-1d73-4ddf-a8d0-37e7ec9f7a21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInterestInJointVenture"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_a3871bf8-ab0b-4f02-b528-f6782aa3a699" xlink:to="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_662c3a15-1d73-4ddf-a8d0-37e7ec9f7a21" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetAssetLiability_fa667c62-8a96-4fb7-b95c-b12645d5331d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueNetAssetLiability"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_a3871bf8-ab0b-4f02-b528-f6782aa3a699" xlink:to="loc_us-gaap_FairValueNetAssetLiability_fa667c62-8a96-4fb7-b95c-b12645d5331d" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/CollaborationandLicensingRevenueSummarizedCollaborationandLicensingRevenuesDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#CollaborationandLicensingRevenueSummarizedCollaborationandLicensingRevenuesDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/CollaborationandLicensingRevenueSummarizedCollaborationandLicensingRevenuesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_595e5e52-9f0d-4f2b-9106-f4824ed8d79d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_0ec6b6a7-693e-46ff-9b6b-fe54c44f7cfe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_595e5e52-9f0d-4f2b-9106-f4824ed8d79d" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_0ec6b6a7-693e-46ff-9b6b-fe54c44f7cfe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_0ec6b6a7-693e-46ff-9b6b-fe54c44f7cfe" xlink:to="loc_srt_CounterpartyNameAxis_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c705d745-72f5-4896-bd02-87f9a0dbf59c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_1c3c18b0-12cb-4b41-8358-7c6bff2cd3f6" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c705d745-72f5-4896-bd02-87f9a0dbf59c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersMember_6945d28d-7fdf-4fc1-a766-8ca8bbd4b8c2" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c705d745-72f5-4896-bd02-87f9a0dbf59c" xlink:to="loc_pgen_IntrexonEnergyPartnersMember_6945d28d-7fdf-4fc1-a766-8ca8bbd4b8c2" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersIILLCMember_e4a768d2-8844-4b43-ab05-8d8cc9c30ae5" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersIILLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c705d745-72f5-4896-bd02-87f9a0dbf59c" xlink:to="loc_pgen_IntrexonEnergyPartnersIILLCMember_e4a768d2-8844-4b43-ab05-8d8cc9c30ae5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_OtherMember_067f51e0-26b5-48cb-a125-9d6574ad3dfa" xlink:href="pgen-20231231.xsd#pgen_OtherMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c705d745-72f5-4896-bd02-87f9a0dbf59c" xlink:to="loc_pgen_OtherMember_067f51e0-26b5-48cb-a125-9d6574ad3dfa" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_c7f64138-9d26-4d17-949a-27dda5497a99" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_0ec6b6a7-693e-46ff-9b6b-fe54c44f7cfe" xlink:to="loc_us-gaap_TypeOfArrangementAxis_c7f64138-9d26-4d17-949a-27dda5497a99" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c7f64138-9d26-4d17-949a-27dda5497a99_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c7f64138-9d26-4d17-949a-27dda5497a99" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c7f64138-9d26-4d17-949a-27dda5497a99_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2271904a-8da1-48d1-90d8-22199d603f58" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c7f64138-9d26-4d17-949a-27dda5497a99" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2271904a-8da1-48d1-90d8-22199d603f58" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_70920ea2-deb9-4b76-8496-9408ebc2c1b6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2271904a-8da1-48d1-90d8-22199d603f58" xlink:to="loc_us-gaap_CollaborativeArrangementMember_70920ea2-deb9-4b76-8496-9408ebc2c1b6" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_UpfrontAndMilestonePaymentsMember_78da4d62-e45c-43f1-b49a-16034dea07da" xlink:href="pgen-20231231.xsd#pgen_UpfrontAndMilestonePaymentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2271904a-8da1-48d1-90d8-22199d603f58" xlink:to="loc_pgen_UpfrontAndMilestonePaymentsMember_78da4d62-e45c-43f1-b49a-16034dea07da" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_48d8a0d1-ed8b-4af5-bb6b-7029f93b1710" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_595e5e52-9f0d-4f2b-9106-f4824ed8d79d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_48d8a0d1-ed8b-4af5-bb6b-7029f93b1710" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_569bb123-3a05-4974-97fc-f11cfa65bd4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_595e5e52-9f0d-4f2b-9106-f4824ed8d79d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_569bb123-3a05-4974-97fc-f11cfa65bd4f" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/CollaborationandLicensingRevenueAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#CollaborationandLicensingRevenueAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/CollaborationandLicensingRevenueAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_CollaborationAgreementsLineItems_00796ff2-956d-43ec-b3d9-ffa95db38ae8" xlink:href="pgen-20231231.xsd#pgen_CollaborationAgreementsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CollaborationAgreementsTable_20d26f4b-973b-4e0e-8fa6-f2fc81b9dded" xlink:href="pgen-20231231.xsd#pgen_CollaborationAgreementsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_CollaborationAgreementsLineItems_00796ff2-956d-43ec-b3d9-ffa95db38ae8" xlink:to="loc_pgen_CollaborationAgreementsTable_20d26f4b-973b-4e0e-8fa6-f2fc81b9dded" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_b6ddad78-7002-46f1-8928-3146ece81d63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_CollaborationAgreementsTable_20d26f4b-973b-4e0e-8fa6-f2fc81b9dded" xlink:to="loc_us-gaap_TypeOfArrangementAxis_b6ddad78-7002-46f1-8928-3146ece81d63" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b6ddad78-7002-46f1-8928-3146ece81d63_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_b6ddad78-7002-46f1-8928-3146ece81d63" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b6ddad78-7002-46f1-8928-3146ece81d63_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a91c40cf-938d-4b35-87a6-2d12f80f890d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_b6ddad78-7002-46f1-8928-3146ece81d63" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a91c40cf-938d-4b35-87a6-2d12f80f890d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_e8add13a-8536-41d8-8e01-f8137f39e2bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a91c40cf-938d-4b35-87a6-2d12f80f890d" xlink:to="loc_us-gaap_CollaborativeArrangementMember_e8add13a-8536-41d8-8e01-f8137f39e2bc" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_AmendedLicensingAgreementBetweenAlaunosAndPrecigen2023Member_d827a3ab-4e52-4166-b60a-d51a9554d309" xlink:href="pgen-20231231.xsd#pgen_AmendedLicensingAgreementBetweenAlaunosAndPrecigen2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a91c40cf-938d-4b35-87a6-2d12f80f890d" xlink:to="loc_pgen_AmendedLicensingAgreementBetweenAlaunosAndPrecigen2023Member_d827a3ab-4e52-4166-b60a-d51a9554d309" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_CollaborationAgreementsTable_20d26f4b-973b-4e0e-8fa6-f2fc81b9dded" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_75df3166-b58d-4031-b244-d385493010c8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_75dc2148-a4a5-4bc6-9af1-f23dcf88b6a7" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_75df3166-b58d-4031-b244-d385493010c8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_92e47c3b-fb90-4577-8988-317a4e616f8b" xlink:href="pgen-20231231.xsd#pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_75df3166-b58d-4031-b244-d385493010c8" xlink:to="loc_pgen_IntrexonEnergyPartnersAndInterxonEnergyPartnersIIMember_92e47c3b-fb90-4577-8988-317a4e616f8b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_1c1a1e1d-83aa-4c43-ad34-dcaec47838a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInterestInJointVenture"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_CollaborationAgreementsLineItems_00796ff2-956d-43ec-b3d9-ffa95db38ae8" xlink:to="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_1c1a1e1d-83aa-4c43-ad34-dcaec47838a3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4d2588d0-b7d0-41ea-995a-1b367d306c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_CollaborationAgreementsLineItems_00796ff2-956d-43ec-b3d9-ffa95db38ae8" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4d2588d0-b7d0-41ea-995a-1b367d306c5b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_LicenseAgreementAnnualFee_eb63c599-1e89-40cd-b003-62ded4260ffe" xlink:href="pgen-20231231.xsd#pgen_LicenseAgreementAnnualFee"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_CollaborationAgreementsLineItems_00796ff2-956d-43ec-b3d9-ffa95db38ae8" xlink:to="loc_pgen_LicenseAgreementAnnualFee_eb63c599-1e89-40cd-b003-62ded4260ffe" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/CollaborationandLicensingRevenueSummaryofDeferredRevenueDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#CollaborationandLicensingRevenueSummaryofDeferredRevenueDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/CollaborationandLicensingRevenueSummaryofDeferredRevenueDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementLineItems_5d2e4bdc-cf6e-4de4-adf9-73a79c44d85b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredRevenueArrangementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementByTypeTable_8ca8cf8f-3c27-404e-9c39-43291c5e6c18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredRevenueArrangementByTypeTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_5d2e4bdc-cf6e-4de4-adf9-73a79c44d85b" xlink:to="loc_us-gaap_DeferredRevenueArrangementByTypeTable_8ca8cf8f-3c27-404e-9c39-43291c5e6c18" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_a92bcdc2-c345-4788-9dbb-77a36188f22e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_8ca8cf8f-3c27-404e-9c39-43291c5e6c18" xlink:to="loc_us-gaap_TypeOfArrangementAxis_a92bcdc2-c345-4788-9dbb-77a36188f22e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a92bcdc2-c345-4788-9dbb-77a36188f22e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a92bcdc2-c345-4788-9dbb-77a36188f22e" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a92bcdc2-c345-4788-9dbb-77a36188f22e_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddac7fe0-9f75-49b4-a252-a35d986a000e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a92bcdc2-c345-4788-9dbb-77a36188f22e" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddac7fe0-9f75-49b4-a252-a35d986a000e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_ec2d2430-c4b7-4fcf-a978-205fcafb58ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddac7fe0-9f75-49b4-a252-a35d986a000e" xlink:to="loc_us-gaap_CollaborativeArrangementMember_ec2d2430-c4b7-4fcf-a978-205fcafb58ce" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_62b38033-1bad-4bb8-a212-9ebfca6a118d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_8ca8cf8f-3c27-404e-9c39-43291c5e6c18" xlink:to="loc_srt_ProductOrServiceAxis_62b38033-1bad-4bb8-a212-9ebfca6a118d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_62b38033-1bad-4bb8-a212-9ebfca6a118d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_62b38033-1bad-4bb8-a212-9ebfca6a118d" xlink:to="loc_srt_ProductsAndServicesDomain_62b38033-1bad-4bb8-a212-9ebfca6a118d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2dd39f49-d86d-4109-9bf3-8a9078274054" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_62b38033-1bad-4bb8-a212-9ebfca6a118d" xlink:to="loc_srt_ProductsAndServicesDomain_2dd39f49-d86d-4109-9bf3-8a9078274054" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrepaidProductAndServiceRevenuesMember_b2e78c33-c2ae-4907-bbbb-c0d669368765" xlink:href="pgen-20231231.xsd#pgen_PrepaidProductAndServiceRevenuesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2dd39f49-d86d-4109-9bf3-8a9078274054" xlink:to="loc_pgen_PrepaidProductAndServiceRevenuesMember_b2e78c33-c2ae-4907-bbbb-c0d669368765" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_DeferredRevenueOtherMember_574d3e6b-1436-469b-b810-33add27ace30" xlink:href="pgen-20231231.xsd#pgen_DeferredRevenueOtherMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2dd39f49-d86d-4109-9bf3-8a9078274054" xlink:to="loc_pgen_DeferredRevenueOtherMember_574d3e6b-1436-469b-b810-33add27ace30" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_5d257139-86a8-4aae-bfff-0aabb3fa2cca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiability"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_5d2e4bdc-cf6e-4de4-adf9-73a79c44d85b" xlink:to="loc_us-gaap_ContractWithCustomerLiability_5d257139-86a8-4aae-bfff-0aabb3fa2cca" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_190bcba1-49f1-4ad6-95dc-6708762ac206" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_5d2e4bdc-cf6e-4de4-adf9-73a79c44d85b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_190bcba1-49f1-4ad6-95dc-6708762ac206" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_b2d2605c-638a-4d78-9226-3f3274943f95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_5d2e4bdc-cf6e-4de4-adf9-73a79c44d85b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_b2d2605c-638a-4d78-9226-3f3274943f95" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShorttermandLongtermInvestmentsSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofInvestmentsDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShorttermandLongtermInvestmentsSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofInvestmentsDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShorttermandLongtermInvestmentsSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofInvestmentsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a437ae73-2dcc-437c-abc9-c35abd1006c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a437ae73-2dcc-437c-abc9-c35abd1006c7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_afe11a28-a9f0-42db-8497-723b9d29368f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a437ae73-2dcc-437c-abc9-c35abd1006c7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_afe11a28-a9f0-42db-8497-723b9d29368f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_afe11a28-a9f0-42db-8497-723b9d29368f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_afe11a28-a9f0-42db-8497-723b9d29368f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_afe11a28-a9f0-42db-8497-723b9d29368f_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0804f87e-e167-47de-afed-405f1343bfc6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_afe11a28-a9f0-42db-8497-723b9d29368f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0804f87e-e167-47de-afed-405f1343bfc6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_d7f9b556-5147-4585-9ac0-20e1a253ec98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0804f87e-e167-47de-afed-405f1343bfc6" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_d7f9b556-5147-4585-9ac0-20e1a253ec98" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_1e09dd77-3b75-462e-939b-358ef249de70" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CertificatesOfDepositMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0804f87e-e167-47de-afed-405f1343bfc6" xlink:to="loc_us-gaap_CertificatesOfDepositMember_1e09dd77-3b75-462e-939b-358ef249de70" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_d8fec2a2-2275-43a2-8821-f8695e71555e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateBondSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0804f87e-e167-47de-afed-405f1343bfc6" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_d8fec2a2-2275-43a2-8821-f8695e71555e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_21f37a65-4973-4349-8282-52ae716b3e72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_21f37a65-4973-4349-8282-52ae716b3e72" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_dc430041-7192-40e0-ace1-b30a4a3a1f53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_dc430041-7192-40e0-ace1-b30a4a3a1f53" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c81f91aa-33aa-4bb3-9a56-4bb67b84d61c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c81f91aa-33aa-4bb3-9a56-4bb67b84d61c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_445ec0fa-e17e-45d1-8257-be089d93197e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_445ec0fa-e17e-45d1-8257-be089d93197e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_91345963-f9a7-47f8-ab46-6e1f41b6de89" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_56f955d3-a942-4201-b1f9-a4aa85acf6e4" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_91345963-f9a7-47f8-ab46-6e1f41b6de89" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/FairValueMeasurementsSummaryofPlacementintheFairValueHierarchyofFinancialAssetsthatareMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#FairValueMeasurementsSummaryofPlacementintheFairValueHierarchyofFinancialAssetsthatareMeasuredatFairValueonaRecurringBasisDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/FairValueMeasurementsSummaryofPlacementintheFairValueHierarchyofFinancialAssetsthatareMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_819010d3-e09a-4db6-b32c-33c8ada3b228" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d1a885d9-134d-451f-b091-bf47d1b17112" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_819010d3-e09a-4db6-b32c-33c8ada3b228" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d1a885d9-134d-451f-b091-bf47d1b17112" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e8ed8fe6-2bc3-4967-8386-46d4ff016e89" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d1a885d9-134d-451f-b091-bf47d1b17112" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e8ed8fe6-2bc3-4967-8386-46d4ff016e89" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_e8ed8fe6-2bc3-4967-8386-46d4ff016e89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e8ed8fe6-2bc3-4967-8386-46d4ff016e89" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_e8ed8fe6-2bc3-4967-8386-46d4ff016e89_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8a916275-a912-40cf-8a88-19b39bed893c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e8ed8fe6-2bc3-4967-8386-46d4ff016e89" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8a916275-a912-40cf-8a88-19b39bed893c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_22f3a5b7-f64a-418a-a6a6-123869b8c363" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8a916275-a912-40cf-8a88-19b39bed893c" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_22f3a5b7-f64a-418a-a6a6-123869b8c363" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_6ca5c7f5-b9a9-480e-a516-18dd8c4cac44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8a916275-a912-40cf-8a88-19b39bed893c" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_6ca5c7f5-b9a9-480e-a516-18dd8c4cac44" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_c9220470-62ed-4b65-86fd-bce571e7f8de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8a916275-a912-40cf-8a88-19b39bed893c" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_c9220470-62ed-4b65-86fd-bce571e7f8de" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_92f53ab5-a7b8-4fee-918d-bf3352f53e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d1a885d9-134d-451f-b091-bf47d1b17112" xlink:to="loc_us-gaap_FinancialInstrumentAxis_92f53ab5-a7b8-4fee-918d-bf3352f53e6b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_92f53ab5-a7b8-4fee-918d-bf3352f53e6b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_92f53ab5-a7b8-4fee-918d-bf3352f53e6b" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_92f53ab5-a7b8-4fee-918d-bf3352f53e6b_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa0ec32-46d9-440a-bc92-1bddd33d2674" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_92f53ab5-a7b8-4fee-918d-bf3352f53e6b" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa0ec32-46d9-440a-bc92-1bddd33d2674" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_a098df7e-e967-429a-80e6-4ec68e27dbf4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa0ec32-46d9-440a-bc92-1bddd33d2674" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_a098df7e-e967-429a-80e6-4ec68e27dbf4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_f28215db-ae3d-4110-8cf9-1327fc198665" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CertificatesOfDepositMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa0ec32-46d9-440a-bc92-1bddd33d2674" xlink:to="loc_us-gaap_CertificatesOfDepositMember_f28215db-ae3d-4110-8cf9-1327fc198665" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_1291a7b6-f1aa-4303-aa48-cdce0638346f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateBondSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa0ec32-46d9-440a-bc92-1bddd33d2674" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_1291a7b6-f1aa-4303-aa48-cdce0638346f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_3d4f10f0-6830-4353-921b-019966ab980d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_819010d3-e09a-4db6-b32c-33c8ada3b228" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_3d4f10f0-6830-4353-921b-019966ab980d" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/FairValueMeasurementsAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#FairValueMeasurementsAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/FairValueMeasurementsAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_746ce015-285a-4755-a4ee-a063c50fca3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7a0451e-527d-4905-a7f7-bc3a6ec493a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_746ce015-285a-4755-a4ee-a063c50fca3e" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7a0451e-527d-4905-a7f7-bc3a6ec493a0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_9703fb2f-fdff-4bef-aabe-1911160bd84c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7a0451e-527d-4905-a7f7-bc3a6ec493a0" xlink:to="loc_us-gaap_DebtInstrumentAxis_9703fb2f-fdff-4bef-aabe-1911160bd84c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9703fb2f-fdff-4bef-aabe-1911160bd84c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_9703fb2f-fdff-4bef-aabe-1911160bd84c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9703fb2f-fdff-4bef-aabe-1911160bd84c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_20ec6359-5ce7-4a7f-900f-bb18cc94438c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_9703fb2f-fdff-4bef-aabe-1911160bd84c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_20ec6359-5ce7-4a7f-900f-bb18cc94438c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_A3.5ConvertibleNotesDue2023Member_457be6ed-0d40-4fc5-b07c-331b6ccf1ed1" xlink:href="pgen-20231231.xsd#pgen_A3.5ConvertibleNotesDue2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_20ec6359-5ce7-4a7f-900f-bb18cc94438c" xlink:to="loc_pgen_A3.5ConvertibleNotesDue2023Member_457be6ed-0d40-4fc5-b07c-331b6ccf1ed1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3accad61-3f28-4155-8c38-e65fa4c7b437" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7a0451e-527d-4905-a7f7-bc3a6ec493a0" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3accad61-3f28-4155-8c38-e65fa4c7b437" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3accad61-3f28-4155-8c38-e65fa4c7b437_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3accad61-3f28-4155-8c38-e65fa4c7b437" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3accad61-3f28-4155-8c38-e65fa4c7b437_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_819db6e8-01d4-4302-b50e-cca1e0da41af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3accad61-3f28-4155-8c38-e65fa4c7b437" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_819db6e8-01d4-4302-b50e-cca1e0da41af" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_012aa477-b7fc-4cfb-a64c-307affced34e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_819db6e8-01d4-4302-b50e-cca1e0da41af" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_012aa477-b7fc-4cfb-a64c-307affced34e" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_df15170f-1038-4234-b488-9db004bf0654" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_746ce015-285a-4755-a4ee-a063c50fca3e" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_df15170f-1038-4234-b488-9db004bf0654" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebt_55255604-0e72-4785-a359-b1d4ba43f5f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_746ce015-285a-4755-a4ee-a063c50fca3e" xlink:to="loc_us-gaap_ConvertibleDebt_55255604-0e72-4785-a359-b1d4ba43f5f7" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/GoodwillandIntangibleAssetsNetScheduleofChangesinCarryingAmountofGoodwillDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#GoodwillandIntangibleAssetsNetScheduleofChangesinCarryingAmountofGoodwillDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/GoodwillandIntangibleAssetsNetScheduleofChangesinCarryingAmountofGoodwillDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_511a7379-4bd7-437d-9939-1112e2a88106" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_fe037617-7f1a-4ae5-b9ef-467f0b4b0a48" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfGoodwillTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_511a7379-4bd7-437d-9939-1112e2a88106" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_fe037617-7f1a-4ae5-b9ef-467f0b4b0a48" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_489644a5-68ef-4238-9eea-ce27a86984af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_fe037617-7f1a-4ae5-b9ef-467f0b4b0a48" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_489644a5-68ef-4238-9eea-ce27a86984af" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_489644a5-68ef-4238-9eea-ce27a86984af_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_489644a5-68ef-4238-9eea-ce27a86984af" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_489644a5-68ef-4238-9eea-ce27a86984af_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_60c397e0-ea70-4041-abe6-6eadc8bd4957" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_489644a5-68ef-4238-9eea-ce27a86984af" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_60c397e0-ea70-4041-abe6-6eadc8bd4957" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_e37dc602-f049-4a91-be99-16d20d8a0eec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentContinuingOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_60c397e0-ea70-4041-abe6-6eadc8bd4957" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_e37dc602-f049-4a91-be99-16d20d8a0eec" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_fe037617-7f1a-4ae5-b9ef-467f0b4b0a48" xlink:to="loc_us-gaap_ReportingUnitAxis_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReportingUnitAxis_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d" xlink:to="loc_us-gaap_ReportingUnitDomain_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_b90ed877-cd17-404d-82ce-f08b836ec6c4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReportingUnitAxis_7cae1ffe-1593-4a5b-b2f7-a6b8ff4aa24d" xlink:to="loc_us-gaap_ReportingUnitDomain_b90ed877-cd17-404d-82ce-f08b836ec6c4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_469fa2ab-fd94-45e6-b1aa-0923c6483d27" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_511a7379-4bd7-437d-9939-1112e2a88106" xlink:to="loc_us-gaap_GoodwillRollForward_469fa2ab-fd94-45e6-b1aa-0923c6483d27" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_4bf1dbe3-e174-46ad-bf35-5b630d6b213c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_469fa2ab-fd94-45e6-b1aa-0923c6483d27" xlink:to="loc_us-gaap_Goodwill_4bf1dbe3-e174-46ad-bf35-5b630d6b213c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_2d96cd07-4fc0-4aa6-9884-35fe93c21c41" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_469fa2ab-fd94-45e6-b1aa-0923c6483d27" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_2d96cd07-4fc0-4aa6-9884-35fe93c21c41" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_ac3dab0c-9d8b-4a07-887a-f0a691e58783" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_469fa2ab-fd94-45e6-b1aa-0923c6483d27" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_ac3dab0c-9d8b-4a07-887a-f0a691e58783" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_c9bf20ac-6992-4339-ad93-b161f45d5718" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/GoodwillandIntangibleAssetsNetAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#GoodwillandIntangibleAssetsNetAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/GoodwillandIntangibleAssetsNetAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_f523b5ea-771d-4aeb-9df8-b9c700a69db5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfGoodwillTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_f523b5ea-771d-4aeb-9df8-b9c700a69db5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_bbaf1714-2eb0-4f9f-b72b-688f820ae247" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_f523b5ea-771d-4aeb-9df8-b9c700a69db5" xlink:to="loc_us-gaap_ReportingUnitAxis_bbaf1714-2eb0-4f9f-b72b-688f820ae247" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_bbaf1714-2eb0-4f9f-b72b-688f820ae247_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReportingUnitAxis_bbaf1714-2eb0-4f9f-b72b-688f820ae247" xlink:to="loc_us-gaap_ReportingUnitDomain_bbaf1714-2eb0-4f9f-b72b-688f820ae247_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_ff98d833-8d98-47cb-836d-79e9d2c863a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReportingUnitDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReportingUnitAxis_bbaf1714-2eb0-4f9f-b72b-688f820ae247" xlink:to="loc_us-gaap_ReportingUnitDomain_ff98d833-8d98-47cb-836d-79e9d2c863a3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarSegmentMember_ee306437-f6bc-46cf-a6cc-08f8623474bb" xlink:href="pgen-20231231.xsd#pgen_ExemplarSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReportingUnitDomain_ff98d833-8d98-47cb-836d-79e9d2c863a3" xlink:to="loc_pgen_ExemplarSegmentMember_ee306437-f6bc-46cf-a6cc-08f8623474bb" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_f523b5ea-771d-4aeb-9df8-b9c700a69db5" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_1826c690-3557-48ce-948f-de62e2a33fee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_1e0725fe-314a-4fb7-a80f-4c1ba9a89d0f" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_1826c690-3557-48ce-948f-de62e2a33fee" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_4113007b-f683-438a-9ca1-0e9d1ff7b194" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentContinuingOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_1826c690-3557-48ce-948f-de62e2a33fee" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_4113007b-f683-438a-9ca1-0e9d1ff7b194" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_00f43908-f35d-4c01-9dbb-7f741cdd1a46" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_00f43908-f35d-4c01-9dbb-7f741cdd1a46" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_8ca88f8d-3b49-44ae-8b41-d6360c697cb7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_8ca88f8d-3b49-44ae-8b41-d6360c697cb7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_4ff2e95e-ca2c-4de9-aa7a-315ea1fcec85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_4ff2e95e-ca2c-4de9-aa7a-315ea1fcec85" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ReportingUnitFairValueMeasurementInputMarketBasedWeightedAverageCostOfCapital_f2ff798e-1c88-4176-828e-1441a333aa1c" xlink:href="pgen-20231231.xsd#pgen_ReportingUnitFairValueMeasurementInputMarketBasedWeightedAverageCostOfCapital"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_pgen_ReportingUnitFairValueMeasurementInputMarketBasedWeightedAverageCostOfCapital_f2ff798e-1c88-4176-828e-1441a333aa1c" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ReportingUnitFairValueMeasurementInputTerminalGrowthRate_46a0a7df-c134-43da-b66d-70a2e4f5571d" xlink:href="pgen-20231231.xsd#pgen_ReportingUnitFairValueMeasurementInputTerminalGrowthRate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_93e01ee0-c9ec-4469-bca8-e514769875d0" xlink:to="loc_pgen_ReportingUnitFairValueMeasurementInputTerminalGrowthRate_46a0a7df-c134-43da-b66d-70a2e4f5571d" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/GoodwillandIntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#GoodwillandIntangibleAssetsNetScheduleofIntangibleAssetsDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/GoodwillandIntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29b283d4-2f92-4e88-87c9-04e9febc5a59" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59b6e675-9689-427a-90c2-9f7383755b46" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29b283d4-2f92-4e88-87c9-04e9febc5a59" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59b6e675-9689-427a-90c2-9f7383755b46" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f5284c25-e8ec-4a00-87e7-287c4378771b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59b6e675-9689-427a-90c2-9f7383755b46" xlink:to="loc_srt_RangeAxis_f5284c25-e8ec-4a00-87e7-287c4378771b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f5284c25-e8ec-4a00-87e7-287c4378771b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f5284c25-e8ec-4a00-87e7-287c4378771b" xlink:to="loc_srt_RangeMember_f5284c25-e8ec-4a00-87e7-287c4378771b_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a1437b0e-f3ee-4322-8a2b-85d7ade5a9d2" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f5284c25-e8ec-4a00-87e7-287c4378771b" xlink:to="loc_srt_RangeMember_a1437b0e-f3ee-4322-8a2b-85d7ade5a9d2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_WeightedAverageMember_3983d36d-4923-459f-877d-b7c1e77b1889" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_WeightedAverageMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_a1437b0e-f3ee-4322-8a2b-85d7ade5a9d2" xlink:to="loc_srt_WeightedAverageMember_3983d36d-4923-459f-877d-b7c1e77b1889" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ab0f900f-7c32-46fc-8768-140326f2c41c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_59b6e675-9689-427a-90c2-9f7383755b46" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ab0f900f-7c32-46fc-8768-140326f2c41c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ab0f900f-7c32-46fc-8768-140326f2c41c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ab0f900f-7c32-46fc-8768-140326f2c41c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ab0f900f-7c32-46fc-8768-140326f2c41c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bcb6c830-b3a8-44c0-b2fd-b7bc3fd7cb18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ab0f900f-7c32-46fc-8768-140326f2c41c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bcb6c830-b3a8-44c0-b2fd-b7bc3fd7cb18" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntellectualPropertyMember_6fb0266c-27a1-45af-b2d0-091764229c98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntellectualPropertyMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bcb6c830-b3a8-44c0-b2fd-b7bc3fd7cb18" xlink:to="loc_us-gaap_IntellectualPropertyMember_6fb0266c-27a1-45af-b2d0-091764229c98" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8fbfacd7-5908-4ff3-98e5-1f62286f9552" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29b283d4-2f92-4e88-87c9-04e9febc5a59" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8fbfacd7-5908-4ff3-98e5-1f62286f9552" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_5f3f942c-10f7-4582-9b5a-da9a51bf7a6c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29b283d4-2f92-4e88-87c9-04e9febc5a59" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_5f3f942c-10f7-4582-9b5a-da9a51bf7a6c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_3019b3f2-2aa9-4348-b8fc-bf354b3ddf17" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_5f3f942c-10f7-4582-9b5a-da9a51bf7a6c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_3019b3f2-2aa9-4348-b8fc-bf354b3ddf17" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_e8e06de3-6d6f-4298-a290-10a7a421580c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_5f3f942c-10f7-4582-9b5a-da9a51bf7a6c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_e8e06de3-6d6f-4298-a290-10a7a421580c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_af6b8238-1a6e-4b31-b4c0-095c2f428026" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_5f3f942c-10f7-4582-9b5a-da9a51bf7a6c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_af6b8238-1a6e-4b31-b4c0-095c2f428026" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/LinesofCreditandLongTermDebtLinesofCreditAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#LinesofCreditandLongTermDebtLinesofCreditAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/LinesofCreditandLongTermDebtLinesofCreditAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_31cd3665-bc97-402c-a2a1-98e781cd1785" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_04c92d79-0698-4800-b8ee-a1a1d342ff40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_31cd3665-bc97-402c-a2a1-98e781cd1785" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_04c92d79-0698-4800-b8ee-a1a1d342ff40" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_f97bfe8f-dcaf-410e-ac08-f6380ac9e397" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_04c92d79-0698-4800-b8ee-a1a1d342ff40" xlink:to="loc_us-gaap_CreditFacilityAxis_f97bfe8f-dcaf-410e-ac08-f6380ac9e397" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_f97bfe8f-dcaf-410e-ac08-f6380ac9e397_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_f97bfe8f-dcaf-410e-ac08-f6380ac9e397" xlink:to="loc_us-gaap_CreditFacilityDomain_f97bfe8f-dcaf-410e-ac08-f6380ac9e397_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_1e22f7d8-cd3e-4c74-bd97-c383937910e6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_f97bfe8f-dcaf-410e-ac08-f6380ac9e397" xlink:to="loc_us-gaap_CreditFacilityDomain_1e22f7d8-cd3e-4c74-bd97-c383937910e6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_c2c5ec5b-f7be-4395-a9cd-1657453b50ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevolvingCreditFacilityMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_1e22f7d8-cd3e-4c74-bd97-c383937910e6" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_c2c5ec5b-f7be-4395-a9cd-1657453b50ee" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_08b72696-311c-4ace-92af-1b94edaab6c6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_04c92d79-0698-4800-b8ee-a1a1d342ff40" xlink:to="loc_dei_LegalEntityAxis_08b72696-311c-4ace-92af-1b94edaab6c6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_08b72696-311c-4ace-92af-1b94edaab6c6_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_08b72696-311c-4ace-92af-1b94edaab6c6" xlink:to="loc_dei_EntityDomain_08b72696-311c-4ace-92af-1b94edaab6c6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_17b64ac3-cd86-4617-a80c-3ec2acbee6a7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_08b72696-311c-4ace-92af-1b94edaab6c6" xlink:to="loc_dei_EntityDomain_17b64ac3-cd86-4617-a80c-3ec2acbee6a7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarGeneticsLLCMember_76ae2c29-ac6a-4067-be15-6ef6aeda53a7" xlink:href="pgen-20231231.xsd#pgen_ExemplarGeneticsLLCMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_17b64ac3-cd86-4617-a80c-3ec2acbee6a7" xlink:to="loc_pgen_ExemplarGeneticsLLCMember_76ae2c29-ac6a-4067-be15-6ef6aeda53a7" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_75f67ba6-806c-44d9-8e5e-b4fbca515ee6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_04c92d79-0698-4800-b8ee-a1a1d342ff40" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_75f67ba6-806c-44d9-8e5e-b4fbca515ee6" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_75f67ba6-806c-44d9-8e5e-b4fbca515ee6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_75f67ba6-806c-44d9-8e5e-b4fbca515ee6" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_75f67ba6-806c-44d9-8e5e-b4fbca515ee6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_ad854fc8-c8e6-48ea-b765-cdfa7f18bd72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_75f67ba6-806c-44d9-8e5e-b4fbca515ee6" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_ad854fc8-c8e6-48ea-b765-cdfa7f18bd72" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_AmericanStateBankMember_40d1831a-00d7-4d39-aeef-b9cd77e0b9c4" xlink:href="pgen-20231231.xsd#pgen_AmericanStateBankMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_ad854fc8-c8e6-48ea-b765-cdfa7f18bd72" xlink:to="loc_pgen_AmericanStateBankMember_40d1831a-00d7-4d39-aeef-b9cd77e0b9c4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_c6aad233-aa38-4a37-a9f1-baf38fce6438" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_31cd3665-bc97-402c-a2a1-98e781cd1785" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_c6aad233-aa38-4a37-a9f1-baf38fce6438" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_7012ed0a-15bc-4b3d-a548-c43ca01dd843" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_31cd3665-bc97-402c-a2a1-98e781cd1785" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_7012ed0a-15bc-4b3d-a548-c43ca01dd843" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_c0341a20-329d-451d-bec8-ea83b2c18775" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCredit"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_31cd3665-bc97-402c-a2a1-98e781cd1785" xlink:to="loc_us-gaap_LineOfCredit_c0341a20-329d-451d-bec8-ea83b2c18775" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/LinesofCreditandLongTermDebtShortTermDebtandConvertibleDebtAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#LinesofCreditandLongTermDebtShortTermDebtandConvertibleDebtAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/LinesofCreditandLongTermDebtShortTermDebtandConvertibleDebtAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_45d4dbad-3927-4701-82a5-d40e3ffb7dc9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_DebtInstrumentTable_45d4dbad-3927-4701-82a5-d40e3ffb7dc9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_f375534b-2a27-41a5-bb96-4f39a27de2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_45d4dbad-3927-4701-82a5-d40e3ffb7dc9" xlink:to="loc_us-gaap_DebtInstrumentAxis_f375534b-2a27-41a5-bb96-4f39a27de2e4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f375534b-2a27-41a5-bb96-4f39a27de2e4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_f375534b-2a27-41a5-bb96-4f39a27de2e4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f375534b-2a27-41a5-bb96-4f39a27de2e4_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a8cf5daf-296a-4a17-84a4-f64007d47043" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_f375534b-2a27-41a5-bb96-4f39a27de2e4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a8cf5daf-296a-4a17-84a4-f64007d47043" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_A3.5ConvertibleNotesDue2023Member_6ffbf085-33af-4fa8-bc41-dc80a67e4e36" xlink:href="pgen-20231231.xsd#pgen_A3.5ConvertibleNotesDue2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a8cf5daf-296a-4a17-84a4-f64007d47043" xlink:to="loc_pgen_A3.5ConvertibleNotesDue2023Member_6ffbf085-33af-4fa8-bc41-dc80a67e4e36" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_021fa050-f0d0-4702-8138-82021719bc53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_45d4dbad-3927-4701-82a5-d40e3ffb7dc9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_021fa050-f0d0-4702-8138-82021719bc53" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_021fa050-f0d0-4702-8138-82021719bc53_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_021fa050-f0d0-4702-8138-82021719bc53" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_021fa050-f0d0-4702-8138-82021719bc53_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_10827a38-2d40-463d-9d3b-b0bd459157c4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_021fa050-f0d0-4702-8138-82021719bc53" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_10827a38-2d40-463d-9d3b-b0bd459157c4" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_ae2fca01-771c-4e68-872f-daa1f2dc9911" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_10827a38-2d40-463d-9d3b-b0bd459157c4" xlink:to="loc_us-gaap_ConvertibleDebtMember_ae2fca01-771c-4e68-872f-daa1f2dc9911" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_7b30325a-3bd0-4f19-aed7-44097989fdfa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_7b30325a-3bd0-4f19-aed7-44097989fdfa" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_36f17e7d-3394-4a48-9415-f442728f60e6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_36f17e7d-3394-4a48-9415-f442728f60e6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_f6ffb621-e5aa-48ad-9431-4e0e3f75d6aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFinanceCostsGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_f6ffb621-e5aa-48ad-9431-4e0e3f75d6aa" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_ba1bfca5-1b9c-417f-b6af-ad0748d6095b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_ba1bfca5-1b9c-417f-b6af-ad0748d6095b" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_ac8f9c3d-1133-4b2c-b664-c2dd8f450cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCash"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_RestrictedCash_ac8f9c3d-1133-4b2c-b664-c2dd8f450cd4" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_88478ac2-8303-4338-ba63-5706dc10ed2b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ExtinguishmentOfDebtAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_88478ac2-8303-4338-ba63-5706dc10ed2b" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a8fe203-03c1-47a8-8227-dfa75a287f81" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a8fe203-03c1-47a8-8227-dfa75a287f81" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_b58addb0-9efa-4cde-9cc1-87a38f651218" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_RestrictedCashCurrent_b58addb0-9efa-4cde-9cc1-87a38f651218" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_33d04c0e-da18-4a91-9808-b22e028f2b93" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63e517df-22af-4741-b3ee-6d0bcdb4806d" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_33d04c0e-da18-4a91-9808-b22e028f2b93" xlink:type="arc" order="8"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/LinesofCreditandLongTermDebtComponentsofInterestExpenseDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#LinesofCreditandLongTermDebtComponentsofInterestExpenseDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/LinesofCreditandLongTermDebtComponentsofInterestExpenseDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_63f3d721-04a6-47cc-93e9-601dfdd86b5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_87b4ac9e-e2ba-4c69-b7eb-881e832577a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63f3d721-04a6-47cc-93e9-601dfdd86b5c" xlink:to="loc_us-gaap_DebtInstrumentTable_87b4ac9e-e2ba-4c69-b7eb-881e832577a7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_ad0c8b22-77f4-4b62-8436-73c309ca657d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_87b4ac9e-e2ba-4c69-b7eb-881e832577a7" xlink:to="loc_us-gaap_DebtInstrumentAxis_ad0c8b22-77f4-4b62-8436-73c309ca657d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_ad0c8b22-77f4-4b62-8436-73c309ca657d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_ad0c8b22-77f4-4b62-8436-73c309ca657d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_ad0c8b22-77f4-4b62-8436-73c309ca657d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1f660220-2b54-4e89-9986-df8d0f2902c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_ad0c8b22-77f4-4b62-8436-73c309ca657d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1f660220-2b54-4e89-9986-df8d0f2902c9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_A3.5ConvertibleNotesDue2023Member_1cb8b2d1-dfcf-4c06-8bd0-7745e6fe75b0" xlink:href="pgen-20231231.xsd#pgen_A3.5ConvertibleNotesDue2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1f660220-2b54-4e89-9986-df8d0f2902c9" xlink:to="loc_pgen_A3.5ConvertibleNotesDue2023Member_1cb8b2d1-dfcf-4c06-8bd0-7745e6fe75b0" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_e9adc390-7d79-4ab5-a56f-43c371eeb05f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63f3d721-04a6-47cc-93e9-601dfdd86b5c" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_e9adc390-7d79-4ab5-a56f-43c371eeb05f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts_c280b6f0-2889-40e3-8fc0-0508b6f821f2" xlink:href="pgen-20231231.xsd#pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63f3d721-04a6-47cc-93e9-601dfdd86b5c" xlink:to="loc_pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts_c280b6f0-2889-40e3-8fc0-0508b6f821f2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_ecdc4b14-90be-4b70-ab7e-cd5581ef1d39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebt"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_63f3d721-04a6-47cc-93e9-601dfdd86b5c" xlink:to="loc_us-gaap_InterestExpenseDebt_ecdc4b14-90be-4b70-ab7e-cd5581ef1d39" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_pgen_IncomeTaxLineItems_21c78120-8b32-485a-912b-148b548ad8e5" xlink:href="pgen-20231231.xsd#pgen_IncomeTaxLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_IncomeTaxTable_df37867f-3f09-4551-a8a2-85c4e11effdd" xlink:href="pgen-20231231.xsd#pgen_IncomeTaxTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_pgen_IncomeTaxLineItems_21c78120-8b32-485a-912b-148b548ad8e5" xlink:to="loc_pgen_IncomeTaxTable_df37867f-3f09-4551-a8a2-85c4e11effdd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_063c41a1-9294-45ac-a0b9-3918b89398d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_pgen_IncomeTaxTable_df37867f-3f09-4551-a8a2-85c4e11effdd" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_063c41a1-9294-45ac-a0b9-3918b89398d2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_063c41a1-9294-45ac-a0b9-3918b89398d2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_063c41a1-9294-45ac-a0b9-3918b89398d2" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_063c41a1-9294-45ac-a0b9-3918b89398d2_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_1878fe4d-d4ea-40dd-bc36-3af11af17309" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_063c41a1-9294-45ac-a0b9-3918b89398d2" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_1878fe4d-d4ea-40dd-bc36-3af11af17309" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_90532a6e-13f1-4f7b-b962-86510bb19873" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DomesticCountryMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_1878fe4d-d4ea-40dd-bc36-3af11af17309" xlink:to="loc_us-gaap_DomesticCountryMember_90532a6e-13f1-4f7b-b962-86510bb19873" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_364b5cd8-9002-467a-98b7-315ced1f0f62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCountryMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_1878fe4d-d4ea-40dd-bc36-3af11af17309" xlink:to="loc_us-gaap_ForeignCountryMember_364b5cd8-9002-467a-98b7-315ced1f0f62" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d0de2d62-6c51-4eee-8e9f-e94c93c799e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_IncomeTaxLineItems_21c78120-8b32-485a-912b-148b548ad8e5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d0de2d62-6c51-4eee-8e9f-e94c93c799e5" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/IncomeTaxesSummaryofValuationAllowanceDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#IncomeTaxesSummaryofValuationAllowanceDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/IncomeTaxesSummaryofValuationAllowanceDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_8a04f663-2b57-4729-a134-6d92a35c5030" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_229b39e6-8ef0-4fab-b147-72ed78461d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_8a04f663-2b57-4729-a134-6d92a35c5030" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_229b39e6-8ef0-4fab-b147-72ed78461d0f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_0e89339b-3151-4ce5-8e2e-00cbde4a6e29" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_229b39e6-8ef0-4fab-b147-72ed78461d0f" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_0e89339b-3151-4ce5-8e2e-00cbde4a6e29" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_0e89339b-3151-4ce5-8e2e-00cbde4a6e29_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_0e89339b-3151-4ce5-8e2e-00cbde4a6e29" xlink:to="loc_us-gaap_TypeOfAdoptionMember_0e89339b-3151-4ce5-8e2e-00cbde4a6e29_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_11d287be-b531-482e-8a62-7891e2bb6650" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_0e89339b-3151-4ce5-8e2e-00cbde4a6e29" xlink:to="loc_us-gaap_TypeOfAdoptionMember_11d287be-b531-482e-8a62-7891e2bb6650" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006Member_d6d75616-f682-4fe0-abd8-f13c24108bb0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountingStandardsUpdate202006Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_11d287be-b531-482e-8a62-7891e2bb6650" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006Member_d6d75616-f682-4fe0-abd8-f13c24108bb0" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_8a04f663-2b57-4729-a134-6d92a35c5030" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4dd2afd4-342d-40c9-bd85-3323b15f4235" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4dd2afd4-342d-40c9-bd85-3323b15f4235" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeInAmountCurrentYearOperations_d7501a08-9730-4cb7-92a7-bc5c336105a8" xlink:href="pgen-20231231.xsd#pgen_ValuationAllowanceDeferredTaxAssetChangeInAmountCurrentYearOperations"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeInAmountCurrentYearOperations_d7501a08-9730-4cb7-92a7-bc5c336105a8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperationsTreatedAsAssetSales_2c5a59f3-a3b6-496e-9ec6-2eb50d651172" xlink:href="pgen-20231231.xsd#pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperationsTreatedAsAssetSales"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperationsTreatedAsAssetSales_2c5a59f3-a3b6-496e-9ec6-2eb50d651172" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperations_9e8469f4-da10-4c0a-8fa6-cc5d79f33cf3" xlink:href="pgen-20231231.xsd#pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperations"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_pgen_ValuationAllowanceDeferredTaxAssetsDiscontinuedOperations_9e8469f4-da10-4c0a-8fa6-cc5d79f33cf3" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeinAmountduetoAdoptionofAccountingPrinciple_faa5a627-8c3a-4298-b780-01b04880b5ec" xlink:href="pgen-20231231.xsd#pgen_ValuationAllowanceDeferredTaxAssetChangeinAmountduetoAdoptionofAccountingPrinciple"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeinAmountduetoAdoptionofAccountingPrinciple_faa5a627-8c3a-4298-b780-01b04880b5ec" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeInForeignCurrencyTranslationAdjustment_3b2451a6-46ff-445d-94c1-101e3dee323c" xlink:href="pgen-20231231.xsd#pgen_ValuationAllowanceDeferredTaxAssetChangeInForeignCurrencyTranslationAdjustment"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_7efbcc89-a34b-4a0e-90e2-72c46b4ba019" xlink:to="loc_pgen_ValuationAllowanceDeferredTaxAssetChangeInForeignCurrencyTranslationAdjustment_3b2451a6-46ff-445d-94c1-101e3dee323c" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_93da930c-97f2-4eb0-aaee-86c0f90d7dd8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#IncomeTaxesAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_665892e1-060e-4b89-8b80-462f5196bc64" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_665892e1-060e-4b89-8b80-462f5196bc64" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_665892e1-060e-4b89-8b80-462f5196bc64" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_d071640c-be5e-41a0-9bce-d424b27c884d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_dd2da1f9-76d4-4c6c-a31c-cac8f734bc35" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_d071640c-be5e-41a0-9bce-d424b27c884d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_GeneratedAfter2017Member_17ca414b-f806-489b-b05c-2f0d9e4f4b8b" xlink:href="pgen-20231231.xsd#pgen_GeneratedAfter2017Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_d071640c-be5e-41a0-9bce-d424b27c884d" xlink:to="loc_pgen_GeneratedAfter2017Member_17ca414b-f806-489b-b05c-2f0d9e4f4b8b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_dd632c3f-4ac0-4bab-97d3-e12875be4de4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_665892e1-060e-4b89-8b80-462f5196bc64" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_dd632c3f-4ac0-4bab-97d3-e12875be4de4" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_dd632c3f-4ac0-4bab-97d3-e12875be4de4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_dd632c3f-4ac0-4bab-97d3-e12875be4de4" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_dd632c3f-4ac0-4bab-97d3-e12875be4de4_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_e60551e3-c00d-4946-b59c-2e0898b97d50" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_dd632c3f-4ac0-4bab-97d3-e12875be4de4" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_e60551e3-c00d-4946-b59c-2e0898b97d50" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_106660b1-fe99-4674-a13d-dae9d23215a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DomesticCountryMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_e60551e3-c00d-4946-b59c-2e0898b97d50" xlink:to="loc_us-gaap_DomesticCountryMember_106660b1-fe99-4674-a13d-dae9d23215a3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_dab24218-c999-4105-a62c-a3905c51e75b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCountryMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_e60551e3-c00d-4946-b59c-2e0898b97d50" xlink:to="loc_us-gaap_ForeignCountryMember_dab24218-c999-4105-a62c-a3905c51e75b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_OperatingLossCarryforwardsAcquiredInAcquisitionOfBusiness_1290c837-d425-4489-acfe-77e99b068509" xlink:href="pgen-20231231.xsd#pgen_OperatingLossCarryforwardsAcquiredInAcquisitionOfBusiness"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:to="loc_pgen_OperatingLossCarryforwardsAcquiredInAcquisitionOfBusiness_1290c837-d425-4489-acfe-77e99b068509" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_58a5cf88-21ae-4441-9e30-9580023532b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLossCarryforwards"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:to="loc_us-gaap_OperatingLossCarryforwards_58a5cf88-21ae-4441-9e30-9580023532b2" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_151db4be-b121-4d8a-aad0-d659a81d8aa2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsCapitalLossCarryforwards"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:to="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_151db4be-b121-4d8a-aad0-d659a81d8aa2" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2405385f-29bc-46d7-9df3-fbfbd0c8a876" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_a10333df-a3a2-4d01-92cc-f2822cb65485" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2405385f-29bc-46d7-9df3-fbfbd0c8a876" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareholdersEquityAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareholdersEquityAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_4f60630c-8593-490b-9836-4d5dd1a42c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfStockByClassTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_4f60630c-8593-490b-9836-4d5dd1a42c2b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6a386f15-0004-470f-b1bc-b371b6f12751" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4f60630c-8593-490b-9836-4d5dd1a42c2b" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6a386f15-0004-470f-b1bc-b371b6f12751" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_6a386f15-0004-470f-b1bc-b371b6f12751_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6a386f15-0004-470f-b1bc-b371b6f12751" xlink:to="loc_us-gaap_RelatedPartyDomain_6a386f15-0004-470f-b1bc-b371b6f12751_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_a34f6abb-90d0-427e-861c-98bc4d5c2d42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6a386f15-0004-470f-b1bc-b371b6f12751" xlink:to="loc_us-gaap_RelatedPartyDomain_a34f6abb-90d0-427e-861c-98bc4d5c2d42" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_AffiliatedEntityMember_7ef90d70-b0e3-40ee-8628-67af9026650e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_AffiliatedEntityMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_a34f6abb-90d0-427e-861c-98bc4d5c2d42" xlink:to="loc_srt_AffiliatedEntityMember_7ef90d70-b0e3-40ee-8628-67af9026650e" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_348bbcb7-9356-44a8-9805-c1843eb7b999" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4f60630c-8593-490b-9836-4d5dd1a42c2b" xlink:to="loc_srt_RangeAxis_348bbcb7-9356-44a8-9805-c1843eb7b999" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_348bbcb7-9356-44a8-9805-c1843eb7b999_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_348bbcb7-9356-44a8-9805-c1843eb7b999" xlink:to="loc_srt_RangeMember_348bbcb7-9356-44a8-9805-c1843eb7b999_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_26557ab3-0e0b-430d-ae71-dcbf124ed3b7" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_348bbcb7-9356-44a8-9805-c1843eb7b999" xlink:to="loc_srt_RangeMember_26557ab3-0e0b-430d-ae71-dcbf124ed3b7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_915b37a1-ecc1-413e-84cc-c0e37af80970" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_26557ab3-0e0b-430d-ae71-dcbf124ed3b7" xlink:to="loc_srt_MaximumMember_915b37a1-ecc1-413e-84cc-c0e37af80970" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_f294614e-e964-4c48-b23c-9a000c960dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_f294614e-e964-4c48-b23c-9a000c960dbf" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_50f92f74-d354-4a9e-8b21-87fcbcf4434a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_50f92f74-d354-4a9e-8b21-87fcbcf4434a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_71235c7e-d3f2-435e-8227-69c0638cdf83" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_71235c7e-d3f2-435e-8227-69c0638cdf83" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OwnshareLendingArrangementSharesIssued_2e82ac13-d415-430d-9232-969408f272e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OwnshareLendingArrangementSharesIssued"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_ddcc73d7-27d6-4186-b182-ce79e61fad99" xlink:to="loc_us-gaap_OwnshareLendingArrangementSharesIssued_2e82ac13-d415-430d-9232-969408f272e1" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeLossDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9d52d8a0-10ac-486a-9d48-a075f45e6b9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9039d0e1-7765-4b3b-afe5-f428631ed3e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9d52d8a0-10ac-486a-9d48-a075f45e6b9e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9039d0e1-7765-4b3b-afe5-f428631ed3e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4d81d1c7-7b78-49a4-a24a-d9092132c5f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9039d0e1-7765-4b3b-afe5-f428631ed3e4" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_4d81d1c7-7b78-49a4-a24a-d9092132c5f1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_4d81d1c7-7b78-49a4-a24a-d9092132c5f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4d81d1c7-7b78-49a4-a24a-d9092132c5f1" xlink:to="loc_us-gaap_EquityComponentDomain_4d81d1c7-7b78-49a4-a24a-d9092132c5f1_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_4a9b0897-1ca6-4a2c-aa95-7191f803b79e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4d81d1c7-7b78-49a4-a24a-d9092132c5f1" xlink:to="loc_us-gaap_EquityComponentDomain_4a9b0897-1ca6-4a2c-aa95-7191f803b79e" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f1bd43b7-320c-4b9d-af65-66cd3b168bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_4a9b0897-1ca6-4a2c-aa95-7191f803b79e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f1bd43b7-320c-4b9d-af65-66cd3b168bd9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_e61baaad-0933-4984-8362-3121143a2e23" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f1bd43b7-320c-4b9d-af65-66cd3b168bd9" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_e61baaad-0933-4984-8362-3121143a2e23" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_fec9bf5c-61c1-44fe-8686-5dd5e562b8ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f1bd43b7-320c-4b9d-af65-66cd3b168bd9" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_fec9bf5c-61c1-44fe-8686-5dd5e562b8ad" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_af81b05e-fcdc-41d6-8add-2ab297521939" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9d52d8a0-10ac-486a-9d48-a075f45e6b9e" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_af81b05e-fcdc-41d6-8add-2ab297521939" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareBasedPaymentsScheduleofStockbasedCompensationExpenseDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareBasedPaymentsScheduleofStockbasedCompensationExpenseDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareBasedPaymentsScheduleofStockbasedCompensationExpenseDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_bbc58374-e535-4c7a-834c-377346f3d14a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e39e750-c039-4ab0-b4fb-ed1d7a6513ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_bbc58374-e535-4c7a-834c-377346f3d14a" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e39e750-c039-4ab0-b4fb-ed1d7a6513ec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_d1ebec91-609c-4fc5-8306-0e35969dfc13" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e39e750-c039-4ab0-b4fb-ed1d7a6513ec" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_d1ebec91-609c-4fc5-8306-0e35969dfc13" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_d1ebec91-609c-4fc5-8306-0e35969dfc13_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d1ebec91-609c-4fc5-8306-0e35969dfc13" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_d1ebec91-609c-4fc5-8306-0e35969dfc13_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d1ebec91-609c-4fc5-8306-0e35969dfc13" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CostOfProductsAndServicesMember_f5b9d2a2-e5ad-4c4c-9e05-ed2d580de77e" xlink:href="pgen-20231231.xsd#pgen_CostOfProductsAndServicesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:to="loc_pgen_CostOfProductsAndServicesMember_f5b9d2a2-e5ad-4c4c-9e05-ed2d580de77e" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d0b1e738-a614-4476-b842-02921f912a08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d0b1e738-a614-4476-b842-02921f912a08" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_e24b07c0-dec6-43cd-86f3-6c3fc7dfa295" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_e24b07c0-dec6-43cd-86f3-6c3fc7dfa295" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_1b03775f-4853-46fc-ad7b-12b2e389219a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDiscontinuedOperationsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cbf01470-0d2f-4c39-9c82-ec44cb401346" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_1b03775f-4853-46fc-ad7b-12b2e389219a" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c22e057a-e8d5-47b3-806c-f8a0129df40e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_bbc58374-e535-4c7a-834c-377346f3d14a" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c22e057a-e8d5-47b3-806c-f8a0129df40e" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareBasedPaymentsAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareBasedPaymentsAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareBasedPaymentsAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_454b2a4c-c5a8-4871-9fa7-c92cefd73f9c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_454b2a4c-c5a8-4871-9fa7-c92cefd73f9c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_05362703-fada-4f48-8e57-fc3df48a5127" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_454b2a4c-c5a8-4871-9fa7-c92cefd73f9c" xlink:to="loc_us-gaap_AwardTypeAxis_05362703-fada-4f48-8e57-fc3df48a5127" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_05362703-fada-4f48-8e57-fc3df48a5127_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_05362703-fada-4f48-8e57-fc3df48a5127" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_05362703-fada-4f48-8e57-fc3df48a5127_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_75cef4eb-7dd1-4ce4-bf80-a7320e7d7116" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_05362703-fada-4f48-8e57-fc3df48a5127" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_75cef4eb-7dd1-4ce4-bf80-a7320e7d7116" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_89c4fde4-0299-4914-8367-4c17d9fa5a40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockOptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_75cef4eb-7dd1-4ce4-bf80-a7320e7d7116" xlink:to="loc_us-gaap_EmployeeStockOptionMember_89c4fde4-0299-4914-8367-4c17d9fa5a40" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_ea9c57c6-5dd6-44b6-9b5f-d2eac48fa447" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_75cef4eb-7dd1-4ce4-bf80-a7320e7d7116" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_ea9c57c6-5dd6-44b6-9b5f-d2eac48fa447" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_2d7025c5-6b66-40ec-8cfb-74c5968610ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_454b2a4c-c5a8-4871-9fa7-c92cefd73f9c" xlink:to="loc_us-gaap_PlanNameAxis_2d7025c5-6b66-40ec-8cfb-74c5968610ce" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2d7025c5-6b66-40ec-8cfb-74c5968610ce_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_2d7025c5-6b66-40ec-8cfb-74c5968610ce" xlink:to="loc_us-gaap_PlanNameDomain_2d7025c5-6b66-40ec-8cfb-74c5968610ce_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_45520d5e-ee53-4b46-90f7-c686d20ed7dc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_2d7025c5-6b66-40ec-8cfb-74c5968610ce" xlink:to="loc_us-gaap_PlanNameDomain_45520d5e-ee53-4b46-90f7-c686d20ed7dc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlansMember_657fc3ae-59a5-4b59-9dad-8f7255f0bcf1" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlansMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_45520d5e-ee53-4b46-90f7-c686d20ed7dc" xlink:to="loc_pgen_PrecigenStockOptionPlansMember_657fc3ae-59a5-4b59-9dad-8f7255f0bcf1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlan2013PlanMember_c922a19d-e334-4ea6-a39e-3dff62f6a109" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlan2013PlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_PrecigenStockOptionPlansMember_657fc3ae-59a5-4b59-9dad-8f7255f0bcf1" xlink:to="loc_pgen_PrecigenStockOptionPlan2013PlanMember_c922a19d-e334-4ea6-a39e-3dff62f6a109" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlan2019PlanMember_a19b5df0-2081-4211-a9ac-120f8ede8ed7" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlan2019PlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_pgen_PrecigenStockOptionPlansMember_657fc3ae-59a5-4b59-9dad-8f7255f0bcf1" xlink:to="loc_pgen_PrecigenStockOptionPlan2019PlanMember_a19b5df0-2081-4211-a9ac-120f8ede8ed7" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlan2023PlanAnd2013PlanMember_9829cb79-711e-4f8d-ac1b-0acd36303aea" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlan2023PlanAnd2013PlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_45520d5e-ee53-4b46-90f7-c686d20ed7dc" xlink:to="loc_pgen_PrecigenStockOptionPlan2023PlanAnd2013PlanMember_9829cb79-711e-4f8d-ac1b-0acd36303aea" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlan2023PlanMember_fb21f867-2dfd-43d3-8e7c-48101f9da33a" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlan2023PlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_45520d5e-ee53-4b46-90f7-c686d20ed7dc" xlink:to="loc_pgen_PrecigenStockOptionPlan2023PlanMember_fb21f867-2dfd-43d3-8e7c-48101f9da33a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9369282f-0e97-4372-9d11-9c541627a109" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9369282f-0e97-4372-9d11-9c541627a109" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_f437837b-6ee5-4d3c-9d54-9d6f82aa2632" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_f437837b-6ee5-4d3c-9d54-9d6f82aa2632" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_edfba17d-2f0b-4cf7-85fa-647ff6d130f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_edfba17d-2f0b-4cf7-85fa-647ff6d130f8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_a9089edb-1574-41fc-ab01-471f3fafd35e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_a9089edb-1574-41fc-ab01-471f3fafd35e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermsOfAward_0bf71918-7d63-4cc0-88d2-039dfeaeddbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermsOfAward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermsOfAward_0bf71918-7d63-4cc0-88d2-039dfeaeddbb" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_8e47aab0-f323-4e09-b66e-abf71d05c9e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_8e47aab0-f323-4e09-b66e-abf71d05c9e2" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_33fb4eed-1ba1-42a3-adb9-0c601fa3fd7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_33fb4eed-1ba1-42a3-adb9-0c601fa3fd7e" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_b48bc6fc-7d99-4b12-aa9a-4c02879d4e06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_b48bc6fc-7d99-4b12-aa9a-4c02879d4e06" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b06613e2-646d-465f-a8f4-79e59791b98d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b06613e2-646d-465f-a8f4-79e59791b98d" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_09676c11-1dbb-40c8-b043-08e282342958" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_09676c11-1dbb-40c8-b043-08e282342958" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_5a9c96cf-60dc-4793-8a09-bd0d562fa10c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_704966c3-2da8-4aa6-af8a-888c1c52d4ac" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_5a9c96cf-60dc-4793-8a09-bd0d562fa10c" xlink:type="arc" order="10"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareBasedPaymentsScheduleofStockOptionActivityDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareBasedPaymentsScheduleofStockOptionActivityDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareBasedPaymentsScheduleofStockOptionActivityDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_189c67e4-0989-464f-9623-af74a4d32470" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8847ec76-7685-43b5-9379-d8ebd24376d1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_189c67e4-0989-464f-9623-af74a4d32470" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8847ec76-7685-43b5-9379-d8ebd24376d1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_74ef9635-2cb0-4c08-8179-f0bfc840c706" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8847ec76-7685-43b5-9379-d8ebd24376d1" xlink:to="loc_us-gaap_PlanNameAxis_74ef9635-2cb0-4c08-8179-f0bfc840c706" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_74ef9635-2cb0-4c08-8179-f0bfc840c706_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_74ef9635-2cb0-4c08-8179-f0bfc840c706" xlink:to="loc_us-gaap_PlanNameDomain_74ef9635-2cb0-4c08-8179-f0bfc840c706_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_d510e064-6c0a-49de-b6ee-ec2b12330d00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_74ef9635-2cb0-4c08-8179-f0bfc840c706" xlink:to="loc_us-gaap_PlanNameDomain_d510e064-6c0a-49de-b6ee-ec2b12330d00" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlansMember_744e1258-e0c0-427d-ac52-f02abf44c257" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlansMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_d510e064-6c0a-49de-b6ee-ec2b12330d00" xlink:to="loc_pgen_PrecigenStockOptionPlansMember_744e1258-e0c0-427d-ac52-f02abf44c257" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_189c67e4-0989-464f-9623-af74a4d32470" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_06f1052e-6263-4dbd-94b5-9ad1c771837b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_06f1052e-6263-4dbd-94b5-9ad1c771837b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_9f311c48-3fd3-474c-8721-bce356279d5b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_9f311c48-3fd3-474c-8721-bce356279d5b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_1ffc33d9-5e89-47ff-b3f8-bbb842df8641" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_1ffc33d9-5e89-47ff-b3f8-bbb842df8641" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_5990aede-bd63-475c-ab42-b834cebe78d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_5990aede-bd63-475c-ab42-b834cebe78d0" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_a2df6316-c58c-4abf-a376-933c74f1bb85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_b55fe575-3f50-45a0-9b63-4655e4ff85a5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_a2df6316-c58c-4abf-a376-933c74f1bb85" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_5484ae9a-5183-4c39-ac15-884218caeb49" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_189c67e4-0989-464f-9623-af74a4d32470" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_21e2aa66-696c-41c7-9c1f-969524a21ee8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_21e2aa66-696c-41c7-9c1f-969524a21ee8" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_860e844d-638f-4c95-9fd3-22e28eddf998" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_860e844d-638f-4c95-9fd3-22e28eddf998" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_433f5b80-fcad-490a-bfb4-dc6e1385357f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_433f5b80-fcad-490a-bfb4-dc6e1385357f" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4bea6bd3-c282-447a-9495-bccc70b3badf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4bea6bd3-c282-447a-9495-bccc70b3badf" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_d24110c6-fef3-4603-8983-f9abd28a312d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_865a0acc-534d-4d51-a7b4-bfb10f9465fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_d24110c6-fef3-4603-8983-f9abd28a312d" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ab1707c6-3fab-4c13-90b3-e8e426518aff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_189c67e4-0989-464f-9623-af74a4d32470" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_21b4c87f-be86-454a-aff9-cf5b5ee33025" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_21b4c87f-be86-454a-aff9-cf5b5ee33025" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_39f5e6c5-126b-4735-954e-0245f2d62166" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_39f5e6c5-126b-4735-954e-0245f2d62166" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_3546ce9a-2e86-4e97-810e-ed4d6a2468cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_3546ce9a-2e86-4e97-810e-ed4d6a2468cf" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_86acea45-ddfb-4ef3-b62f-b0437f7199ac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_5f090dac-6cca-4c33-87d4-ca9c5b468453" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_86acea45-ddfb-4ef3-b62f-b0437f7199ac" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/ShareBasedPaymentsScheduleofRestrictedStockUnitActivityDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#ShareBasedPaymentsScheduleofRestrictedStockUnitActivityDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/ShareBasedPaymentsScheduleofRestrictedStockUnitActivityDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d76c9dce-7c53-4e90-86ff-26a4d66b17bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_eb8000cd-edaa-4fb6-a1df-db27e4204440" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d76c9dce-7c53-4e90-86ff-26a4d66b17bb" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_eb8000cd-edaa-4fb6-a1df-db27e4204440" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_20fc7fde-b00f-4b28-afe5-63f95171e3dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_eb8000cd-edaa-4fb6-a1df-db27e4204440" xlink:to="loc_us-gaap_PlanNameAxis_20fc7fde-b00f-4b28-afe5-63f95171e3dd" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_20fc7fde-b00f-4b28-afe5-63f95171e3dd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_20fc7fde-b00f-4b28-afe5-63f95171e3dd" xlink:to="loc_us-gaap_PlanNameDomain_20fc7fde-b00f-4b28-afe5-63f95171e3dd_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_9ed7a699-2c9f-447b-9902-f70a21d2ec1b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_20fc7fde-b00f-4b28-afe5-63f95171e3dd" xlink:to="loc_us-gaap_PlanNameDomain_9ed7a699-2c9f-447b-9902-f70a21d2ec1b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenStockOptionPlansMember_d9c55aa2-9c43-4fcc-9eed-a103b14ed1b2" xlink:href="pgen-20231231.xsd#pgen_PrecigenStockOptionPlansMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_9ed7a699-2c9f-447b-9902-f70a21d2ec1b" xlink:to="loc_pgen_PrecigenStockOptionPlansMember_d9c55aa2-9c43-4fcc-9eed-a103b14ed1b2" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d76c9dce-7c53-4e90-86ff-26a4d66b17bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_34b48369-5c30-403e-9fb7-541dfdb69488" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_34b48369-5c30-403e-9fb7-541dfdb69488" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5db4cf8b-d610-4b41-abb1-0aa1b1a34f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5db4cf8b-d610-4b41-abb1-0aa1b1a34f1b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_40cf0762-43e8-4bcf-9d19-ebe92ef3fa8e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_40cf0762-43e8-4bcf-9d19-ebe92ef3fa8e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_c45e6bf7-1f29-4e91-b31b-4f71c66c3099" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_3e3d6e93-a8ba-4943-a9e3-c581b1e9f794" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_c45e6bf7-1f29-4e91-b31b-4f71c66c3099" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_85856e13-9cea-45d5-9f69-c3fb12512364" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d76c9dce-7c53-4e90-86ff-26a4d66b17bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_fd5d35a6-2773-4775-95fb-33952cddc9fa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_fd5d35a6-2773-4775-95fb-33952cddc9fa" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3d392500-7c16-4043-92dd-5040c9615036" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3d392500-7c16-4043-92dd-5040c9615036" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_e588b2ac-504a-4c35-8a08-e5074005cc7c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_e588b2ac-504a-4c35-8a08-e5074005cc7c" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_03c0cbf0-f7f3-43c2-bbb2-603e149cc60a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_6f59b3ba-ae78-4805-811a-db814b043f01" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_03c0cbf0-f7f3-43c2-bbb2-603e149cc60a" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_f576834e-4647-40a7-8fc4-2c90f4a007d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_c51c0102-7719-4e68-9093-a5f070ed0d3b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d76c9dce-7c53-4e90-86ff-26a4d66b17bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_c51c0102-7719-4e68-9093-a5f070ed0d3b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_a79af4e2-8841-4e46-a69b-2f6bd9c3a7f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_c51c0102-7719-4e68-9093-a5f070ed0d3b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_a79af4e2-8841-4e46-a69b-2f6bd9c3a7f5" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/CommitmentsandContingenciesContingenciesAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#CommitmentsandContingenciesContingenciesAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/CommitmentsandContingenciesContingenciesAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_f54802b1-eb31-4c54-a183-d051fcd226c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_dd6d61fb-0b0d-47e5-bae7-9f8823a7ec92" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_f54802b1-eb31-4c54-a183-d051fcd226c9" xlink:to="loc_us-gaap_LossContingenciesTable_dd6d61fb-0b0d-47e5-bae7-9f8823a7ec92" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_0ddd0650-8b2f-479b-a6a3-6ab6cc887005" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_dd6d61fb-0b0d-47e5-bae7-9f8823a7ec92" xlink:to="loc_srt_LitigationCaseAxis_0ddd0650-8b2f-479b-a6a3-6ab6cc887005" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0ddd0650-8b2f-479b-a6a3-6ab6cc887005_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_0ddd0650-8b2f-479b-a6a3-6ab6cc887005" xlink:to="loc_srt_LitigationCaseTypeDomain_0ddd0650-8b2f-479b-a6a3-6ab6cc887005_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_98956c74-ce7b-4bfb-9ff8-fe613a12179b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_0ddd0650-8b2f-479b-a6a3-6ab6cc887005" xlink:to="loc_srt_LitigationCaseTypeDomain_98956c74-ce7b-4bfb-9ff8-fe613a12179b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PrecigenSecuritiesLitigationMember_59b9dc15-49c8-446b-99f9-e42bbc842d26" xlink:href="pgen-20231231.xsd#pgen_PrecigenSecuritiesLitigationMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_98956c74-ce7b-4bfb-9ff8-fe613a12179b" xlink:to="loc_pgen_PrecigenSecuritiesLitigationMember_59b9dc15-49c8-446b-99f9-e42bbc842d26" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_02ff53ca-2739-443a-a4bc-bbe2dcf4e4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyDamagesAwardedValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_f54802b1-eb31-4c54-a183-d051fcd226c9" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_02ff53ca-2739-443a-a4bc-bbe2dcf4e4bd" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InsuranceSettlementsReceivable_3e02d77f-a767-46e4-a0f7-a140690d4fac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InsuranceSettlementsReceivable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_f54802b1-eb31-4c54-a183-d051fcd226c9" xlink:to="loc_us-gaap_InsuranceSettlementsReceivable_3e02d77f-a767-46e4-a0f7-a140690d4fac" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_42ebae63-ba51-4a43-a0d0-20920447f336" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyEstimateOfPossibleLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_f54802b1-eb31-4c54-a183-d051fcd226c9" xlink:to="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_42ebae63-ba51-4a43-a0d0-20920447f336" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/OperatingLeasesAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#OperatingLeasesAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/OperatingLeasesAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_23ef11d7-5388-486e-8f24-9ac71c39d128" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_8070bb47-286d-4d7f-b2ce-0b1f960383db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_23ef11d7-5388-486e-8f24-9ac71c39d128" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_8070bb47-286d-4d7f-b2ce-0b1f960383db" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ad77bd4a-2f27-449a-bb5c-f6263a95dbed" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_8070bb47-286d-4d7f-b2ce-0b1f960383db" xlink:to="loc_srt_RangeAxis_ad77bd4a-2f27-449a-bb5c-f6263a95dbed" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ad77bd4a-2f27-449a-bb5c-f6263a95dbed_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_ad77bd4a-2f27-449a-bb5c-f6263a95dbed" xlink:to="loc_srt_RangeMember_ad77bd4a-2f27-449a-bb5c-f6263a95dbed_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_34ca23e3-a91c-4ef5-9e20-eddc7601f79c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_ad77bd4a-2f27-449a-bb5c-f6263a95dbed" xlink:to="loc_srt_RangeMember_34ca23e3-a91c-4ef5-9e20-eddc7601f79c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_c89d63db-92f0-4b27-a7f0-722adac328ec" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_34ca23e3-a91c-4ef5-9e20-eddc7601f79c" xlink:to="loc_srt_MinimumMember_c89d63db-92f0-4b27-a7f0-722adac328ec" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_038f1807-70c0-41c8-a5d8-a5a4e6c4e5ee" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_34ca23e3-a91c-4ef5-9e20-eddc7601f79c" xlink:to="loc_srt_MaximumMember_038f1807-70c0-41c8-a5d8-a5a4e6c4e5ee" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_2454d061-cc7e-4878-8c8c-04f2c0b79867" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseRemainingLeaseTerm"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_23ef11d7-5388-486e-8f24-9ac71c39d128" xlink:to="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_2454d061-cc7e-4878-8c8c-04f2c0b79867" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_LesseeOperatingLeaseTerminationPeriod_50d0339b-ae61-45ad-8381-62d528ec02d8" xlink:href="pgen-20231231.xsd#pgen_LesseeOperatingLeaseTerminationPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_23ef11d7-5388-486e-8f24-9ac71c39d128" xlink:to="loc_pgen_LesseeOperatingLeaseTerminationPeriod_50d0339b-ae61-45ad-8381-62d528ec02d8" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SegmentsAdjustedEBITDAbyReportableSegmentDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SegmentsAdjustedEBITDAbyReportableSegmentDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SegmentsAdjustedEBITDAbyReportableSegmentDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_8b5fe8c8-cf17-4890-9119-84495a2ac4a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_28d29a0b-3054-4618-82d4-3e398ad704b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8b5fe8c8-cf17-4890-9119-84495a2ac4a0" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_28d29a0b-3054-4618-82d4-3e398ad704b2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_963c60bb-b5b4-48d4-adff-5e907025e5a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_28d29a0b-3054-4618-82d4-3e398ad704b2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_963c60bb-b5b4-48d4-adff-5e907025e5a0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_963c60bb-b5b4-48d4-adff-5e907025e5a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_963c60bb-b5b4-48d4-adff-5e907025e5a0" xlink:to="loc_us-gaap_SegmentDomain_963c60bb-b5b4-48d4-adff-5e907025e5a0_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_6f577314-3044-489d-934c-794d6667fc15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_963c60bb-b5b4-48d4-adff-5e907025e5a0" xlink:to="loc_us-gaap_SegmentDomain_6f577314-3044-489d-934c-794d6667fc15" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_BiopharmaceuticalsSegmentMember_cc40fe10-37b4-4707-97e1-c331834f75be" xlink:href="pgen-20231231.xsd#pgen_BiopharmaceuticalsSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f577314-3044-489d-934c-794d6667fc15" xlink:to="loc_pgen_BiopharmaceuticalsSegmentMember_cc40fe10-37b4-4707-97e1-c331834f75be" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarSegmentMember_ff8a0931-2f37-4839-bced-844b71ee233a" xlink:href="pgen-20231231.xsd#pgen_ExemplarSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f577314-3044-489d-934c-794d6667fc15" xlink:to="loc_pgen_ExemplarSegmentMember_ff8a0931-2f37-4839-bced-844b71ee233a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates_57c6b7a4-52e7-4264-8eb0-342037ea22b8" xlink:href="pgen-20231231.xsd#pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8b5fe8c8-cf17-4890-9119-84495a2ac4a0" xlink:to="loc_pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates_57c6b7a4-52e7-4264-8eb0-342037ea22b8" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SegmentsReconciliationofNetLossBeforeIncomeTaxesDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SegmentsReconciliationofNetLossBeforeIncomeTaxesDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SegmentsReconciliationofNetLossBeforeIncomeTaxesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_e47e5016-497f-4deb-a211-d4a27daab0ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_e47e5016-497f-4deb-a211-d4a27daab0ce" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_e47e5016-497f-4deb-a211-d4a27daab0ce_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_e47e5016-497f-4deb-a211-d4a27daab0ce" xlink:to="loc_us-gaap_SegmentDomain_e47e5016-497f-4deb-a211-d4a27daab0ce_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_ef4f3114-657b-4d38-92e9-0f7f5a935de1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_e47e5016-497f-4deb-a211-d4a27daab0ce" xlink:to="loc_us-gaap_SegmentDomain_ef4f3114-657b-4d38-92e9-0f7f5a935de1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ReportableSegmentsMember_2b75c369-8049-40aa-b0d3-d7e049158a43" xlink:href="pgen-20231231.xsd#pgen_ReportableSegmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ef4f3114-657b-4d38-92e9-0f7f5a935de1" xlink:to="loc_pgen_ReportableSegmentsMember_2b75c369-8049-40aa-b0d3-d7e049158a43" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_6666f0a5-a95e-42c6-9e97-8e40e620b078" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:to="loc_srt_ConsolidationItemsAxis_6666f0a5-a95e-42c6-9e97-8e40e620b078" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_6666f0a5-a95e-42c6-9e97-8e40e620b078_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_6666f0a5-a95e-42c6-9e97-8e40e620b078" xlink:to="loc_srt_ConsolidationItemsDomain_6666f0a5-a95e-42c6-9e97-8e40e620b078_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_b15c0102-b4f7-49f2-b62e-fcc863c02c18" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_6666f0a5-a95e-42c6-9e97-8e40e620b078" xlink:to="loc_srt_ConsolidationItemsDomain_b15c0102-b4f7-49f2-b62e-fcc863c02c18" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_fe7f4119-29e1-4c30-bc40-dc44b88c39c8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingSegmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_b15c0102-b4f7-49f2-b62e-fcc863c02c18" xlink:to="loc_us-gaap_OperatingSegmentsMember_fe7f4119-29e1-4c30-bc40-dc44b88c39c8" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CorporateAndReconcilingItemsMember_bdc8bf86-60f2-450b-922e-44588e6de23a" xlink:href="pgen-20231231.xsd#pgen_CorporateAndReconcilingItemsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_b15c0102-b4f7-49f2-b62e-fcc863c02c18" xlink:to="loc_pgen_CorporateAndReconcilingItemsMember_bdc8bf86-60f2-450b-922e-44588e6de23a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntersegmentEliminationMember_4a4d569b-ea42-45e2-8ca2-4cf52ab7867f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntersegmentEliminationMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_b15c0102-b4f7-49f2-b62e-fcc863c02c18" xlink:to="loc_us-gaap_IntersegmentEliminationMember_4a4d569b-ea42-45e2-8ca2-4cf52ab7867f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:to="loc_us-gaap_TypeOfArrangementAxis_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_17688a3d-0ac5-4332-9469-1576b917181d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6aec9ae7-1af0-4af4-b8f2-e96f2a7216e5" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_17688a3d-0ac5-4332-9469-1576b917181d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_UpfrontAndMilestonePaymentsMember_29072503-a642-4465-a1e3-17a4d30f80ed" xlink:href="pgen-20231231.xsd#pgen_UpfrontAndMilestonePaymentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_17688a3d-0ac5-4332-9469-1576b917181d" xlink:to="loc_pgen_UpfrontAndMilestonePaymentsMember_29072503-a642-4465-a1e3-17a4d30f80ed" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_9868d379-8509-40c2-9f3f-6fa982b4611c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6e44a67-0191-450c-936b-f1e3f76d2daa" xlink:to="loc_srt_ProductOrServiceAxis_9868d379-8509-40c2-9f3f-6fa982b4611c" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9868d379-8509-40c2-9f3f-6fa982b4611c_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_9868d379-8509-40c2-9f3f-6fa982b4611c" xlink:to="loc_srt_ProductsAndServicesDomain_9868d379-8509-40c2-9f3f-6fa982b4611c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9eec0660-a15d-4581-ad78-4def9bf322ec" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_9868d379-8509-40c2-9f3f-6fa982b4611c" xlink:to="loc_srt_ProductsAndServicesDomain_9eec0660-a15d-4581-ad78-4def9bf322ec" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_UpfrontAndMilestonePaymentsMember_927a1dcf-2b6f-4726-91ab-d1ccc07abcbf" xlink:href="pgen-20231231.xsd#pgen_UpfrontAndMilestonePaymentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_9eec0660-a15d-4581-ad78-4def9bf322ec" xlink:to="loc_pgen_UpfrontAndMilestonePaymentsMember_927a1dcf-2b6f-4726-91ab-d1ccc07abcbf" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates_9753d30e-2094-4eeb-93d3-13b2602e1fa3" xlink:href="pgen-20231231.xsd#pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates_9753d30e-2094-4eeb-93d3-13b2602e1fa3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_CapitalExpendituresNetOfProceedsFromSaleOfAssetsAndInvestmentsInAffiliates_910bfbe0-2855-406e-bd91-2226b09106de" xlink:href="pgen-20231231.xsd#pgen_CapitalExpendituresNetOfProceedsFromSaleOfAssetsAndInvestmentsInAffiliates"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_pgen_CapitalExpendituresNetOfProceedsFromSaleOfAssetsAndInvestmentsInAffiliates_910bfbe0-2855-406e-bd91-2226b09106de" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_11fd2dfc-5544-41c3-99c3-14f760d8015d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeNonoperating"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_11fd2dfc-5544-41c3-99c3-14f760d8015d" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_b06b0be7-c9ea-4b83-b3f0-7236f7d04f73" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_b06b0be7-c9ea-4b83-b3f0-7236f7d04f73" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_83516425-bb31-4780-a860-016a8cf076af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_InterestExpense_83516425-bb31-4780-a860-016a8cf076af" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_d0b135d4-126e-4cc6-8571-90c7796ee52f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_d0b135d4-126e-4cc6-8571-90c7796ee52f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_f9e7c052-3dc9-4c3d-a4c7-1d2e99419e4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_f9e7c052-3dc9-4c3d-a4c7-1d2e99419e4f" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_82b7e510-35d1-454a-9bd7-5a285f9825e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_AssetImpairmentCharges_82b7e510-35d1-454a-9bd7-5a285f9825e4" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_91c99189-5640-420b-a287-f244f980ce6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_91c99189-5640-420b-a287-f244f980ce6e" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_AdjustmentForBonusesPaidInEquityAwards_58747eea-98a4-4e15-9fd0-ed59b6f01b15" xlink:href="pgen-20231231.xsd#pgen_AdjustmentForBonusesPaidInEquityAwards"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_pgen_AdjustmentForBonusesPaidInEquityAwards_58747eea-98a4-4e15-9fd0-ed59b6f01b15" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d900e8bf-b2cf-427f-be0b-90f26085ede5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d900e8bf-b2cf-427f-be0b-90f26085ede5" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_02298e76-b446-43c8-9675-1a7c4c2d841e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_02298e76-b446-43c8-9675-1a7c4c2d841e" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_4b86a8ad-4885-4bbd-b5d2-c07ad578b6af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncashIncomeExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemConsolidatedAbstract_ddeb527e-5dc1-4ca8-95c2-ac06a613aee7" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_4b86a8ad-4885-4bbd-b5d2-c07ad578b6af" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_75a599f9-92c0-4713-a544-cc8a61cceacd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_39eee64f-db61-45ef-93db-78e752bcd9e4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_75a599f9-92c0-4713-a544-cc8a61cceacd" xlink:type="arc" order="5"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SegmentsRevenuesbyReportableSegmentDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SegmentsRevenuesbyReportableSegmentDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SegmentsRevenuesbyReportableSegmentDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_fee5b179-ff70-463f-a0e7-4c7a910e4123" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3fe60f4a-c333-4181-a138-14cd2a903103" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fee5b179-ff70-463f-a0e7-4c7a910e4123" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3fe60f4a-c333-4181-a138-14cd2a903103" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_85275624-048e-426f-8302-8922b51ee630" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3fe60f4a-c333-4181-a138-14cd2a903103" xlink:to="loc_srt_ConsolidationItemsAxis_85275624-048e-426f-8302-8922b51ee630" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_85275624-048e-426f-8302-8922b51ee630_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_85275624-048e-426f-8302-8922b51ee630" xlink:to="loc_srt_ConsolidationItemsDomain_85275624-048e-426f-8302-8922b51ee630_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_7b93739c-747d-4a7e-b45a-1cf8aac5e931" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_85275624-048e-426f-8302-8922b51ee630" xlink:to="loc_srt_ConsolidationItemsDomain_7b93739c-747d-4a7e-b45a-1cf8aac5e931" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_a521f7d8-78f0-46a6-af7e-a346463568f3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingSegmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_7b93739c-747d-4a7e-b45a-1cf8aac5e931" xlink:to="loc_us-gaap_OperatingSegmentsMember_a521f7d8-78f0-46a6-af7e-a346463568f3" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_1c5e318d-2772-4029-97ed-dcc26270a8a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3fe60f4a-c333-4181-a138-14cd2a903103" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_1c5e318d-2772-4029-97ed-dcc26270a8a8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_1c5e318d-2772-4029-97ed-dcc26270a8a8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1c5e318d-2772-4029-97ed-dcc26270a8a8" xlink:to="loc_us-gaap_SegmentDomain_1c5e318d-2772-4029-97ed-dcc26270a8a8_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_4ab4d789-3b05-4d86-8a1c-8fedee9a2c19" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1c5e318d-2772-4029-97ed-dcc26270a8a8" xlink:to="loc_us-gaap_SegmentDomain_4ab4d789-3b05-4d86-8a1c-8fedee9a2c19" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_BiopharmaceuticalsSegmentMember_b3bdefe8-44a1-42cb-ae49-a757d97c05c6" xlink:href="pgen-20231231.xsd#pgen_BiopharmaceuticalsSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ab4d789-3b05-4d86-8a1c-8fedee9a2c19" xlink:to="loc_pgen_BiopharmaceuticalsSegmentMember_b3bdefe8-44a1-42cb-ae49-a757d97c05c6" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarSegmentMember_8e559a43-bbfd-4869-956b-38dad7509e0f" xlink:href="pgen-20231231.xsd#pgen_ExemplarSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ab4d789-3b05-4d86-8a1c-8fedee9a2c19" xlink:to="loc_pgen_ExemplarSegmentMember_8e559a43-bbfd-4869-956b-38dad7509e0f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2adb8bac-6179-4b21-8801-04916bb8db4b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fee5b179-ff70-463f-a0e7-4c7a910e4123" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2adb8bac-6179-4b21-8801-04916bb8db4b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_4fc3a1ff-5833-4171-9103-ce8d2646b150" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fee5b179-ff70-463f-a0e7-4c7a910e4123" xlink:to="loc_us-gaap_Revenues_4fc3a1ff-5833-4171-9103-ce8d2646b150" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SegmentsAdditionalInformationDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SegmentsAdditionalInformationDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SegmentsAdditionalInformationDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0579ce10-e219-4cf0-8a12-a00772d273d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0579ce10-e219-4cf0-8a12-a00772d273d9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_0e47c851-18ea-43a8-bcae-d4b19bb4963c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0579ce10-e219-4cf0-8a12-a00772d273d9" xlink:to="loc_srt_StatementGeographicalAxis_0e47c851-18ea-43a8-bcae-d4b19bb4963c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_0e47c851-18ea-43a8-bcae-d4b19bb4963c_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_0e47c851-18ea-43a8-bcae-d4b19bb4963c" xlink:to="loc_srt_SegmentGeographicalDomain_0e47c851-18ea-43a8-bcae-d4b19bb4963c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4293f855-f9ee-4598-b9f0-c26fe6e1c320" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_0e47c851-18ea-43a8-bcae-d4b19bb4963c" xlink:to="loc_srt_SegmentGeographicalDomain_4293f855-f9ee-4598-b9f0-c26fe6e1c320" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_efe3877d-25fa-4c67-a6f3-7ae65a7f0818" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonUsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_4293f855-f9ee-4598-b9f0-c26fe6e1c320" xlink:to="loc_us-gaap_NonUsMember_efe3877d-25fa-4c67-a6f3-7ae65a7f0818" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0579ce10-e219-4cf0-8a12-a00772d273d9" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83" xlink:to="loc_us-gaap_SegmentDomain_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_15a6f9db-d817-4dc0-b3b2-9361d884acd6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_51e5e4ff-c9e0-4124-8d6a-1346cafd3e83" xlink:to="loc_us-gaap_SegmentDomain_15a6f9db-d817-4dc0-b3b2-9361d884acd6" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarSegmentMember_c7c96d9f-7cc5-4481-9750-9fc6e3329d5a" xlink:href="pgen-20231231.xsd#pgen_ExemplarSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_15a6f9db-d817-4dc0-b3b2-9361d884acd6" xlink:to="loc_pgen_ExemplarSegmentMember_c7c96d9f-7cc5-4481-9750-9fc6e3329d5a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_PercentageOfRevenueAttributableToCustomer_4033bd1f-6671-4bfa-be19-05ac3521585d" xlink:href="pgen-20231231.xsd#pgen_PercentageOfRevenueAttributableToCustomer"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:to="loc_pgen_PercentageOfRevenueAttributableToCustomer_4033bd1f-6671-4bfa-be19-05ac3521585d" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_NumberOfCustomers_4b9649f8-49d2-4607-804d-b89ad350da48" xlink:href="pgen-20231231.xsd#pgen_NumberOfCustomers"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:to="loc_pgen_NumberOfCustomers_4b9649f8-49d2-4607-804d-b89ad350da48" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_a94c1409-26ea-4e46-9495-ae1c38c7306b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:to="loc_us-gaap_Revenues_a94c1409-26ea-4e46-9495-ae1c38c7306b" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_LongLivedAssetsIncludingPropertyPlantandEquipmentandRightOfUseAssets_5fa50466-aead-4797-9221-5b0c245d5058" xlink:href="pgen-20231231.xsd#pgen_LongLivedAssetsIncludingPropertyPlantandEquipmentandRightOfUseAssets"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f1ce6916-e558-4fad-8dec-a95df05e4403" xlink:to="loc_pgen_LongLivedAssetsIncludingPropertyPlantandEquipmentandRightOfUseAssets_5fa50466-aead-4797-9221-5b0c245d5058" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.dna.com/role/SegmentsGoodwillDetails" xlink:type="simple" xlink:href="pgen-20231231.xsd#SegmentsGoodwillDetails"/>
<link:definitionLink xlink:role="http://www.dna.com/role/SegmentsGoodwillDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_01ac7eef-f404-40c9-9fa1-28cdd0ea6ec5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_fcc85a1b-dd48-4895-8cc0-90619c19efa2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01ac7eef-f404-40c9-9fa1-28cdd0ea6ec5" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_fcc85a1b-dd48-4895-8cc0-90619c19efa2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_ff3b4718-7689-4049-9214-ce1e8f28afc1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_fcc85a1b-dd48-4895-8cc0-90619c19efa2" xlink:to="loc_srt_ConsolidationItemsAxis_ff3b4718-7689-4049-9214-ce1e8f28afc1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_ff3b4718-7689-4049-9214-ce1e8f28afc1_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_ff3b4718-7689-4049-9214-ce1e8f28afc1" xlink:to="loc_srt_ConsolidationItemsDomain_ff3b4718-7689-4049-9214-ce1e8f28afc1_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_fbd66d80-6f4f-493d-9e01-5465be5403d3" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_ff3b4718-7689-4049-9214-ce1e8f28afc1" xlink:to="loc_srt_ConsolidationItemsDomain_fbd66d80-6f4f-493d-9e01-5465be5403d3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_36998e5f-9bdf-4ec7-be42-9f464d2b34e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingSegmentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_fbd66d80-6f4f-493d-9e01-5465be5403d3" xlink:to="loc_us-gaap_OperatingSegmentsMember_36998e5f-9bdf-4ec7-be42-9f464d2b34e4" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_d157fa6c-9cf0-420c-b384-67051c691dd6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_fcc85a1b-dd48-4895-8cc0-90619c19efa2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_d157fa6c-9cf0-420c-b384-67051c691dd6" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_d157fa6c-9cf0-420c-b384-67051c691dd6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_d157fa6c-9cf0-420c-b384-67051c691dd6" xlink:to="loc_us-gaap_SegmentDomain_d157fa6c-9cf0-420c-b384-67051c691dd6_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_3d842983-d9f4-41a1-aa6c-a36359f92c34" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_d157fa6c-9cf0-420c-b384-67051c691dd6" xlink:to="loc_us-gaap_SegmentDomain_3d842983-d9f4-41a1-aa6c-a36359f92c34" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_BiopharmaceuticalsSegmentMember_4e74a62c-b820-4b96-821a-6c950ab7127c" xlink:href="pgen-20231231.xsd#pgen_BiopharmaceuticalsSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3d842983-d9f4-41a1-aa6c-a36359f92c34" xlink:to="loc_pgen_BiopharmaceuticalsSegmentMember_4e74a62c-b820-4b96-821a-6c950ab7127c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_pgen_ExemplarSegmentMember_fe101b33-f358-4da7-a448-0b320e665281" xlink:href="pgen-20231231.xsd#pgen_ExemplarSegmentMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3d842983-d9f4-41a1-aa6c-a36359f92c34" xlink:to="loc_pgen_ExemplarSegmentMember_fe101b33-f358-4da7-a448-0b320e665281" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_ea18bbd3-4882-4b2c-a2da-f88d8b582e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01ac7eef-f404-40c9-9fa1-28cdd0ea6ec5" xlink:to="loc_us-gaap_GoodwillRollForward_ea18bbd3-4882-4b2c-a2da-f88d8b582e8a" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_3bbfa7e0-5b9e-4410-8df1-06ca5600ca5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_ea18bbd3-4882-4b2c-a2da-f88d8b582e8a" xlink:to="loc_us-gaap_Goodwill_3bbfa7e0-5b9e-4410-8df1-06ca5600ca5c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_dcaab0e9-ac30-4b01-b411-16e8f10794f0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_ea18bbd3-4882-4b2c-a2da-f88d8b582e8a" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_dcaab0e9-ac30-4b01-b411-16e8f10794f0" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_97754f46-1cea-45e7-a283-07826fc6e645" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillImpairmentLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_ea18bbd3-4882-4b2c-a2da-f88d8b582e8a" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_97754f46-1cea-45e7-a283-07826fc6e645" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_e48815ee-a0e1-406b-b2ff-13f65f836bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
</link:definitionLink>
<link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-roles-2023.xsd#eedm"/>
<link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfAdoptionMember"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountingStandardsUpdate202006Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementAbstract"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetImpairmentCharges" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetImpairmentCharges"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract" xlink:to="loc_us-gaap_OtherAssetImpairmentCharges" xlink:type="arc" order="1"/>
</link:definitionLink>
</link:linkbase>

21 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/09/23  Precigen, Inc.                    10-Q        6/30/23   93:17M
 7/06/23  Precigen, Inc.                    S-8         7/06/23    5:212K                                   Davis Polk & … LLP 01/FA
11/09/20  Precigen, Inc.                    10-Q        9/30/20  117:12M
 6/22/20  Precigen, Inc.                    S-3                    7:747K                                   Donnelley … Solutions/FA
 6/19/20  Precigen, Inc.                    8-K:5,9     6/19/20   11:175K                                   Donnelley … Solutions/FA
 6/04/20  Precigen, Inc.                    8-K:5,9     6/03/20   11:295K                                   Donnelley … Solutions/FA
 5/11/20  Precigen, Inc.                    10-Q        3/31/20  111:10M
 3/02/20  Precigen, Inc.                    10-K       12/31/19  141:33M                                    Workiva Inc Wde… FA01/FA
 2/04/20  Precigen, Inc.                    8-K:2,5,8,9 1/30/20   13:379K                                   Donnelley … Solutions/FA
 1/07/20  Precigen, Inc.                    8-K:5,9     1/01/20   11:240K                                   Donnelley … Solutions/FA
 8/09/19  Precigen, Inc.                    10-Q        6/30/19  116:12M
 6/12/19  Precigen, Inc.                    8-K:5,9     6/12/19    2:43K                                    Donnelley … Solutions/FA
 5/09/19  Precigen, Inc.                    10-Q        3/31/19  109:8.9M
 6/08/18  Precigen, Inc.                    8-K:5,9     6/07/18    2:36K                                    Donnelley … Solutions/FA
 3/01/18  Precigen, Inc.                    10-K       12/31/17  138:16M
 6/30/17  Precigen, Inc.                    8-K:5,9     6/28/17    2:35K                                    Donnelley … Solutions/FA
 6/13/16  Precigen, Inc.                    8-K:5,9     6/09/16    2:29K                                    Donnelley … Solutions/FA
 6/17/15  Precigen, Inc.                    8-K:5,9     6/11/15    3:101K                                   Donnelley … Solutions/FA
 1/14/15  Precigen, Inc.                    8-K:1,3,9   1/09/15    6:489K                                   Donnelley … Solutions/FA
 6/13/14  Precigen, Inc.                    8-K:5,9     6/09/14    5:407K                                   Donnelley … Solutions/FA
 7/29/13  Precigen, Inc.                    S-1/A                 15:5.3M                                   Donnelley … Solutions/FA
↑Top
Filing Submission 0001356090-24-000007   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Mon., May 13, 8:14:54.2am ET