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| | | <link:roleType roleURI="http://opko.com/role/DerivativeContracts" id="DerivativeContracts"> |
| <link:definition> 0209 - Disclosure - Derivative Contracts </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://opko.com/role/RelatedPartyTransactions" id="RelatedPartyTransactions"> |
| <link:definition> 0210 - Disclosure - Related Party Transactions </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://opko.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies"> |
| <link:definition> 0211 - Disclosure - Commitments and Contingencies </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://opko.com/role/Segments" id="Segments"> |
| <link:definition> 0212 - Disclosure - Segments </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://opko.com/role/SubsequentEvents" id="SubsequentEvents"> |
| <link:definition> 0214 - Disclosure - Subsequent Events </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| </link:roleType> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="opk-20130331_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links, all"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="opk-20130331_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links, all"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="opk-20130331_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Label Links, all"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="opk-20130331_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links, all"/> |
| | | </appinfo> |
| | </annotation> |
| <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/> |
| <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/> |
| <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/> |
| <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/> |
| <import namespace="http://fasb.org/us-gaap/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/exch/2012-01-31" schemaLocation="http://xbrl.sec.gov/exch/2012/exch-2012-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/country/2012-01-31" schemaLocation="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd"/> |
| <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/> |
| <import namespace="http://xbrl.sec.gov/currency/2012-01-31" schemaLocation="http://xbrl.sec.gov/currency/2012/currency-2012-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/> |
| <element name="DocumentAndEntityInformationAbstract" id="opk_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/> |
| <element id="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" name="GainLossFromContinuingOperationsBeforeInvestmentLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_WeightedAverageNumberOfCommonShareOutstandingBasicAndDiluted" name="WeightedAverageNumberOfCommonShareOutstandingBasicAndDiluted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ProvisionRecoveryOfForDoubtfulAccounts" name="ProvisionRecoveryOfForDoubtfulAccounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_ProvisionForReversalOfInventoryReserves" name="ProvisionForReversalOfInventoryReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_SummaryOfSignificantAccountingPoliciesTextualAbstract" name="SummaryOfSignificantAccountingPoliciesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SorrentoMember" name="SorrentoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CocrystalMember" name="CocrystalMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FabrusMember" name="FabrusMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_TesaroMember" name="TesaroMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NeovascMember" name="NeovascMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ZeroToThirtyMember" name="ZeroToThirtyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ThirtyOneToSixtyMember" name="ThirtyOneToSixtyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SixtyOneToNinetyMember" name="SixtyOneToNinetyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NinetyOneToOneHundredTwentyMember" name="NinetyOneToOneHundredTwentyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_OneHundredTwentyOneToOneHundredEightyMember" name="OneHundredTwentyOneToOneHundredEightyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_MoreThanOneHundredEightyMember" name="MoreThanOneHundredEightyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_GammaTrustMember" name="GammaTrustMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_HsuGammaMember" name="HsuGammaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AgreementPursuantToWhichInvested" name="AgreementPursuantToWhichInvested" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_CommitmentsAndContingenciesTextualAbstract" name="CommitmentsAndContingenciesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SegmentsTextualAbstract" name="SegmentsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AllowanceForDoubtfulAccountsPolicyTextBlock" name="AllowanceForDoubtfulAccountsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" name="CompositionOfCertainFinancialStatementCaptionsTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract" name="BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" name="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_VariableInterestEntityEntityAccountingMethod" name="VariableInterestEntityEntityAccountingMethod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_VariableInterestEntityEntityAccumulatedLossesInInvestees" name="VariableInterestEntityEntityAccumulatedLossesInInvestees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract" name="FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" name="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_FinancingForVariableInterestEntities" name="FinancingForVariableInterestEntities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_OwnershipPercentageHeldByMembers" name="OwnershipPercentageHeldByMembers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_MaximumOwnershipPercentageHeldByMembers" name="MaximumOwnershipPercentageHeldByMembers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_ManagementTwoMember" name="ManagementTwoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ManagementFourMember" name="ManagementFourMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_OwnershipPercentageHeldByDirector" name="OwnershipPercentageHeldByDirector" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PreviousInvestmentByGroupOfInvestor" name="PreviousInvestmentByGroupOfInvestor" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_AdditionalInvestmentByGroupOfInvestor" name="AdditionalInvestmentByGroupOfInvestor" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_RealEstateHoldingsLlcMember" name="RealEstateHoldingsLlcMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" name="LeaseSpaceInOfficeBuildingHavingPrincipalOffice" type="num:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LeaseRentPerMonthForFirstYear" name="LeaseRentPerMonthForFirstYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_CreditForTenantImprovements" name="CreditForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_ReimbursementPaidToRelatedPartyForTravel" name="ReimbursementPaidToRelatedPartyForTravel" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_LeaseRentPerMonthForFifthYear" name="LeaseRentPerMonthForFifthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" name="ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AccountsReceivableFromMajorCustomer" name="AccountsReceivableFromMajorCustomer" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" name="MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" name="MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_RelatedPartyTransactionsTextualAbstract" name="RelatedPartyTransactionsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_RelatedPartyTransactionsAdditionalTextualAbstract" name="RelatedPartyTransactionsAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NumberOfReportableSegment" name="NumberOfReportableSegment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" name="NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_OutstandingCommonSharesAcquired" name="OutstandingCommonSharesAcquired" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_NumberOfEqualInstallmentsPayableForAdditionalInvestment" name="NumberOfEqualInstallmentsPayableForAdditionalInvestment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_FirstInstallmentInvestment" name="FirstInstallmentInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_RevenueFromReceiptOfEquity" name="RevenueFromReceiptOfEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_ContingentConsiderationLongTermObligations" name="ContingentConsiderationLongTermObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_EquityInvestmentYear" name="EquityInvestmentYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_FinetechContingentConsiderationMember" name="FinetechContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_WarrantsDuration" name="WarrantsDuration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" name="EffectOfLossOnForeignCurrencyDerivativeBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_NeovascOptionsMember" name="NeovascOptionsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FabrusIncMember" name="FabrusIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NumberOfCustomerRepresentation" name="NumberOfCustomerRepresentation" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_UnrealizedGainOnInvestmentsOptionsAndWarrants" name="UnrealizedGainOnInvestmentsOptionsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_NumberOfTradingDays" name="NumberOfTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AccruedClinicalTrials" name="AccruedClinicalTrials" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_FairValueOfContingentConsiderationPeriodIncrease" name="FairValueOfContingentConsiderationPeriodIncrease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_IssuanceOfCommonStockInPrivatePlacementIncludingRelatedPartiesPerShare" name="IssuanceOfCommonStockInPrivatePlacementIncludingRelatedPartiesPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_RepaymentsOfLinesOfCreditAndCapitalLeaseObligations" name="RepaymentsOfLinesOfCreditAndCapitalLeaseObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_DebtTextualAbstract" name="DebtTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DerivativeContractsTextualAbstract" name="DerivativeContractsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ExerciseOfCommonWarrant" name="ExerciseOfCommonWarrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_ExerciseOfCommonWarrantsShares" name="ExerciseOfCommonWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ItauBankMember" name="ItauBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BankOfChileMember" name="BankOfChileMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BiceBankMember" name="BiceBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SantanderBankMember" name="SantanderBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CorpBancaMember" name="CorpBancaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BbvaBankMember" name="BbvaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BciMember" name="BciMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SecurityMember" name="SecurityMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FiniteLivedResearchAndDevelopmentInProcess" name="FiniteLivedResearchAndDevelopmentInProcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_DrFrostMember" name="DrFrostMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ForeignExchangeRate" name="ForeignExchangeRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PercentageOfCustomerInRevenue" name="PercentageOfCustomerInRevenue" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_OurlabMember" name="OurlabMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ShortTermInvestmentsMaturitiesPeriodMinimum" name="ShortTermInvestmentsMaturitiesPeriodMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ShortTermInvestmentsMaturitiesPeriodMaximum" name="ShortTermInvestmentsMaturitiesPeriodMaximum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LongTermInvestmentsMaturitiesPeriodMinimum" name="LongTermInvestmentsMaturitiesPeriodMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" name="BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_BusinessAcquisitionPurchasePricePatentsExpensed" name="BusinessAcquisitionPurchasePricePatentsExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" name="CompositionsOfCertainFinancialStatementCaptionsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_OwnershipPercentageHeld" name="OwnershipPercentageHeld" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_FairValueMeasurementTextualAbstract" name="FairValueMeasurementTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AlsMember" name="AlsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SciGenMember" name="SciGenMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BiozonePharmaceuticalsIncMember" name="BiozonePharmaceuticalsIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ChromaDexMember" name="ChromaDexMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BiozoneMember" name="BiozoneMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FarmadietAcquisitionMember" name="FarmadietAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" name="PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" name="PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" name="PortionOfPaidOnFirstAnniversaryOfClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PortionOfPaidInEighteenMonthsAfterClosingDate" name="PortionOfPaidInEighteenMonthsAfterClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_DeferredAcquisitionPaymentsNetOfDiscount" name="DeferredAcquisitionPaymentsNetOfDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_DeferredAcquisitionPaymentsDiscount" name="DeferredAcquisitionPaymentsDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_DeferredPaymentToSatisfyIndemnityClaims" name="DeferredPaymentToSatisfyIndemnityClaims" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_NumberOfAncillaryTransaction" name="NumberOfAncillaryTransaction" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_AncillaryTransactionDetails" name="AncillaryTransactionDetails" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_NumberOfSharesIssuedAtClosingDate" name="NumberOfSharesIssuedAtClosingDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_NumberOfSharesIssuedUponAchievingCertainMilestone" name="NumberOfSharesIssuedUponAchievingCertainMilestone" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" name="PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_AmountPayableOnCashOrSharesOnAchievingMilestones" name="AmountPayableOnCashOrSharesOnAchievingMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_ProductInDevelopmentMember" name="ProductInDevelopmentMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" name="BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" name="ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PromissoryNotesMaturityDate" name="PromissoryNotesMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_WarrantsToPurchaseCommonShares" name="WarrantsToPurchaseCommonShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FarmadietContingentConsiderationMember" name="FarmadietContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PentaBankMember" name="PentaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EstadoBankMember" name="EstadoBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SabadellBankMember" name="SabadellBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BilbaoVizcayaBankMember" name="BilbaoVizcayaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BancoPopularMember" name="BancoPopularMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BanestoMember" name="BanestoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BancaMarchMember" name="BancaMarchMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ResearchAgreementMaturityPeriod" name="ResearchAgreementMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FundForResearchAgreement" name="FundForResearchAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_DrLernerMember" name="DrLernerMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AeroPharmaceuticalsIncMember" name="AeroPharmaceuticalsIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_MrPregoNovoMember" name="MrPregoNovoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DiagnosticsMember" name="DiagnosticsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DeferredAcquisitionPaymentsNetOfDiscountMember" name="DeferredAcquisitionPaymentsNetOfDiscountMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ContingentConsiderationMember" name="ContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AdditionsToReconciliationOfFairValueMeasurement" name="AdditionsToReconciliationOfFairValueMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" name="ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CommonStockInvestmentsMember" name="CommonStockInvestmentsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BzneNoteAndBeneficialConversationFeatureMember" name="BzneNoteAndBeneficialConversationFeatureMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_TevaPharmaceuticalIndustriesMember" name="TevaPharmaceuticalIndustriesMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LoanToBzne" name="LoanToBzne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_BusinessAcquisitionSharePriceOnSharesIssue" name="BusinessAcquisitionSharePriceOnSharesIssue" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_VariableInterestEntityOwnershipAmount" name="VariableInterestEntityOwnershipAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PercentageOfIncreaseDecreaseInDiscountRate" name="PercentageOfIncreaseDecreaseInDiscountRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PercentageOfIncreaseDecreaseInFutureSales" name="PercentageOfIncreaseDecreaseInFutureSales" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_OpkoDiagnosticsContingentConsiderationMember" name="OpkoDiagnosticsContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" name="DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_LossContingencyRecoveryOfCompensatoryDamages" name="LossContingencyRecoveryOfCompensatoryDamages" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_NumberOfSharesReceivedUnderAssetPurchaseAgreement" name="NumberOfSharesReceivedUnderAssetPurchaseAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EstimatedMilestonePaymentToBeReceived" name="EstimatedMilestonePaymentToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_AcquisitionsInvestmentsAndLicensesTextualAbstract" name="AcquisitionsInvestmentsAndLicensesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssuedHeldInEscrowAccount" name="BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssuedHeldInEscrowAccount" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionInterestHeldByThirdPartyInAcquireeSubsidiariesPercentage" name="BusinessAcquisitionInterestHeldByThirdPartyInAcquireeSubsidiariesPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_RxiPharmaceuticalsCorporationMember" name="RxiPharmaceuticalsCorporationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AviPropertiesLlcMember" name="AviPropertiesLlcMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ScrippsResearchInstituteMember" name="ScrippsResearchInstituteMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_TermOfLease" name="TermOfLease" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PercentageIncreaseInConsumerPriceIndex" name="PercentageIncreaseInConsumerPriceIndex" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ResearchFundingAndOptionAgreementAnnualAmount" name="ResearchFundingAndOptionAgreementAnnualAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_ResearchFundingAndOptionAgreementPeriodOfPayment" name="ResearchFundingAndOptionAgreementPeriodOfPayment" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LeaseExtendedPeriod" name="LeaseExtendedPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LossPerShareTextualAbstract" name="LossPerShareTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SilconMember" name="SilconMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CytochromaMember" name="CytochromaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CytochromaAcquisitionMember" name="CytochromaAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_RxiMember" name="RxiMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AcquisitionsInvestmentsAndLicensesAdditionalTextualAbstract" name="AcquisitionsInvestmentsAndLicensesAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CytochromaContingentConsiderationMember" name="CytochromaContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_AccumulatedOtherComprehensiveIncomeTextualAbstract" name="AccumulatedOtherComprehensiveIncomeTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EquityMethodInvestmentNumberOfSharesPurchased" name="EquityMethodInvestmentNumberOfSharesPurchased" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EquityMethodInvestmentAmountOfSharesPurchased" name="EquityMethodInvestmentAmountOfSharesPurchased" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_EquityMethodInvestmentAmountOfFinancing" name="EquityMethodInvestmentAmountOfFinancing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_NumberOfMinimumTradingDaysApplicableForConversionPrice" name="NumberOfMinimumTradingDaysApplicableForConversionPrice" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NumberOfDaysInConsecutiveTradingPeriodForRedemption" name="NumberOfDaysInConsecutiveTradingPeriodForRedemption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_GrossUnrealizedGainsIncludedInAccumulatedOtherComprehensiveIncomeLoss" name="GrossUnrealizedGainsIncludedInAccumulatedOtherComprehensiveIncomeLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/> |
| <element id="opk_GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLossBeforeReclassificationNetOfTax" name="GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLossBeforeReclassificationNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLossReclassificationNetOfTax" name="GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLossReclassificationNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLoss" name="GrossUnrealizedGainsIncludedInOtherComprehensiveIncomeLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_DebtInstrumentPercentageOfConversionPrice" name="DebtInstrumentPercentageOfConversionPrice" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentRedemptionPriceAsPercentageOfPrincipalAmount" name="DebtInstrumentRedemptionPriceAsPercentageOfPrincipalAmount" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentRedemptionPeriodDescription" name="DebtInstrumentRedemptionPeriodDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_IssuanceOfCommonStockToAcquireEntity" name="IssuanceOfCommonStockToAcquireEntity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_NumberOfCommonStockWarrantAndCommonStockOptionsExercised" name="NumberOfCommonStockWarrantAndCommonStockOptionsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SharesSurrenderedInLieuOfCashPayment" name="SharesSurrenderedInLieuOfCashPayment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NumberOfCommonStockIssuedForStockWarrantAndStockOptionsExercised" name="NumberOfCommonStockIssuedForStockWarrantAndStockOptionsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_MortgagesAndOtherDebtsPayable" name="MortgagesAndOtherDebtsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_SeriesDPreferredStockRedemptionTextualAbstract" name="SeriesDPreferredStockRedemptionTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SubsequentEventTextualAbstract" name="SubsequentEventTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" name="BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_StockReceivedDuringPeriodSharesCommonStock" name="StockReceivedDuringPeriodSharesCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_StockIssuedDuringPeriodSharesConversionAbstract" name="StockIssuedDuringPeriodSharesConversionAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_StockIssuedDuringPeriodSharesAcquisitionAbstract" name="StockIssuedDuringPeriodSharesAcquisitionAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ClosingSharePriceOfInvestmentsAvailableForSale" name="ClosingSharePriceOfInvestmentsAvailableForSale" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_BusinessAcquisitionShareExchangeRatio" name="BusinessAcquisitionShareExchangeRatio" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_BusinessAcquisitionSharePriceOfAcquiree" name="BusinessAcquisitionSharePriceOfAcquiree" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_DeferredRevenueRelatedToOtherRevenues" name="DeferredRevenueRelatedToOtherRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_NumberOfFinancialInstitutions" name="NumberOfFinancialInstitutions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_DebtInstrumentMaturityYearStart" name="DebtInstrumentMaturityYearStart" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentMaturityYearEnd" name="DebtInstrumentMaturityYearEnd" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NumberOfOperatingSegment" name="NumberOfOperatingSegment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/> |
| <element id="opk_PercentageOfShareholdingByChairmanOfAcquireeCompany" name="PercentageOfShareholdingByChairmanOfAcquireeCompany" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_PercentageOfShareholdingByDirectorsOfAcquireeCompany" name="PercentageOfShareholdingByDirectorsOfAcquireeCompany" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionNumberOfPhlebotomySites" name="BusinessAcquisitionNumberOfPhlebotomySites" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_IncreaseDecreaseInForeignCurrencyMeasurement" name="IncreaseDecreaseInForeignCurrencyMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" name="FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_InputsToLatticeModelUsedToValueEmbeddedDerivativeAbstract" name="InputsToLatticeModelUsedToValueEmbeddedDerivativeAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesAbstract" name="FairValueOfNotesWithAndWithoutEmbeddedDerivativesAndFairValueOfEmbeddedDerivativesAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecrease" name="BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationIfEstimatedFutureSalesDecrease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/> |
| <element id="opk_BusinessAcquisitionsByAcquisitionContingentConsiderationPolicyTextBlock" name="BusinessAcquisitionsByAcquisitionContingentConsiderationPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentConvertibleInputsUsedToValueEmbeddedDerivativeTableTextBlock" name="DebtInstrumentConvertibleInputsUsedToValueEmbeddedDerivativeTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_LicenseRevenue" name="LicenseRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentConvertibleMaturityDate" name="DebtInstrumentConvertibleMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentExpectedStockVolatilityRate" name="DebtInstrumentExpectedStockVolatilityRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FairValueOfNotesWithAndWithoutEmbeddedDerivativeAbstract" name="FairValueOfNotesWithAndWithoutEmbeddedDerivativeAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EstimatedFairValueOfEmbeddedDerivatives" name="EstimatedFairValueOfEmbeddedDerivatives" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_DebtInstrumentConversionPrice" name="DebtInstrumentConversionPrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_FairValueOfNotesWithoutEmbeddedDerivative" name="FairValueOfNotesWithoutEmbeddedDerivative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_FairValueOfNotesWithEmbeddedDerivative" name="FairValueOfNotesWithEmbeddedDerivative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_BusinessAcquisitionPeriodForPaymentOfPurchasePriceToAcquireEntity" name="BusinessAcquisitionPeriodForPaymentOfPurchasePriceToAcquireEntity" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_ProFormaResultOfCombinedCompaniesTableTextBlock" name="ProFormaResultOfCombinedCompaniesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" name="BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_EmbeddedConversionOptionMember" name="EmbeddedConversionOptionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_TransferOutToEquityMethodInvestment" name="TransferOutToEquityMethodInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/> |
| <element id="opk_ScheduleOfPrincipalAmountsUnamortizedDiscountAndNetCarryingAmountsAbstract" name="ScheduleOfPrincipalAmountsUnamortizedDiscountAndNetCarryingAmountsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_SummaryOfLossesRecordedInFairValueChangesOfDerivativeFinancialInstrumentsAbstract" name="SummaryOfLossesRecordedInFairValueChangesOfDerivativeFinancialInstrumentsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_DebtInstrumentPrincipalAmountForConversion" name="DebtInstrumentPrincipalAmountForConversion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/> |
| <element id="opk_LossContingencyClaimForImpositionOfConstructiveTrustNumber" name="LossContingencyClaimForImpositionOfConstructiveTrustNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| <element id="opk_NotesAndForwardContractsMember" name="NotesAndForwardContractsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/> |
| </schema> |