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<!-- Extended XBRL Calculation Linkbase Created with Tagger by RR Donnelley version 10.0.0.240 --> |
<!-- Based on XBRL 2.1 --> |
<!-- Modified on: 5/10/2013 7:17:23 AM --> |
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| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_ProvisionForReversalOfInventoryReserves" order="140" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_RevenueFromReceiptOfEquity" xlink:label="opk_RevenueFromReceiptOfEquity"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_RevenueFromReceiptOfEquity" order="160" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_FairValueOfContingentConsiderationPeriodIncrease" xlink:label="opk_FairValueOfContingentConsiderationPeriodIncrease"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_FairValueOfContingentConsiderationPeriodIncrease" order="200" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="us-gaap_DeferredIncomeTaxExpenseBenefit"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_DeferredIncomeTaxExpenseBenefit" order="220" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_IncreaseDecreaseInAccountsReceivable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccountsReceivable" order="240" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_IncreaseDecreaseInInventories"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInInventories" order="260" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" order="280" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_IncreaseDecreaseInOtherOperatingAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInOtherOperatingAssets" order="300" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_IncreaseDecreaseInAccountsPayable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccountsPayable" order="320" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_IncreaseDecreaseInAccruedLiabilities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccruedLiabilities" order="360" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations" xlink:label="us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations" order="2.5" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_IncreaseDecreaseInForeignCurrencyMeasurement" xlink:label="opk_IncreaseDecreaseInForeignCurrencyMeasurement"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_IncreaseDecreaseInForeignCurrencyMeasurement" order="330" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" order="5" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedGainLossNet" xlink:label="us-gaap_AvailableForSaleSecuritiesGrossRealizedGainLossNet"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_AvailableForSaleSecuritiesGrossRealizedGainLossNet" order="5" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInFairValueOfUnhedgedDerivativeInstruments" xlink:label="us-gaap_IncreaseDecreaseInFairValueOfUnhedgedDerivativeInstruments"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_IncreaseDecreaseInFairValueOfUnhedgedDerivativeInstruments" order="1.25" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_ProfitLoss" order="0.625" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="us-gaap_AmortizationOfFinancingCosts"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_AmortizationOfFinancingCosts" order="110" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaidInKindInterest" xlink:label="us-gaap_PaidInKindInterest"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="us-gaap_PaidInKindInterest" order="115" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#BusinessAndOrganization" roleURI="http://opko.com/role/BusinessAndOrganization"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/BusinessAndOrganization" xlink:title="0201 - Disclosure - Business and Organization"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#SummaryOfSignificantAccountingPolicies" roleURI="http://opko.com/role/SummaryOfSignificantAccountingPolicies"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="0202 - Disclosure - Summary of Significant Accounting Policies"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#CompositionOfCertainFinancialStatementCaptions" roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptions"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CompositionOfCertainFinancialStatementCaptions" xlink:title="0204 - Disclosure - Composition of Certain Financial Statement Captions"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#DerivativeContracts" roleURI="http://opko.com/role/DerivativeContracts"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContracts" xlink:title="0209 - Disclosure - Derivative Contracts"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#RelatedPartyTransactions" roleURI="http://opko.com/role/RelatedPartyTransactions"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactions" xlink:title="0210 - Disclosure - Related Party Transactions"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#CommitmentsAndContingencies" roleURI="http://opko.com/role/CommitmentsAndContingencies"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingencies" xlink:title="0211 - Disclosure - Commitments and Contingencies"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#Segments" roleURI="http://opko.com/role/Segments"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/Segments" xlink:title="0212 - Disclosure - Segments"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20130331.xsd#SubsequentEvents" roleURI="http://opko.com/role/SubsequentEvents"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEvents" xlink:title="0214 - Disclosure - Subsequent Events"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="0402 - Disclosure - Summary of Significant Accounting Policies (Policies)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsTables" xlink:title="0509 - Disclosure - Derivative Contracts (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsTables" xlink:title="0512 - Disclosure - Segments (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0609 - Disclosure - Derivative Contracts (Details)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ForeignCurrencyDerivativesAtFairValueNet" xlink:label="loc_ForeignCurrencyDerivativesAtFairValueNet"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NotionalAmountOfForeignCurrencyDerivatives" xlink:label="loc_NotionalAmountOfForeignCurrencyDerivatives"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ForeignCurrencyDerivativesAtFairValueNet" xlink:to="loc_NotionalAmountOfForeignCurrencyDerivatives" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" xlink:label="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ForeignCurrencyDerivativesAtFairValueNet" xlink:to="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" order="10" use="optional" weight="-1" priority="1"/> |
| | </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0611 - Disclosure - Commitments and Contingencies (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0612 - Disclosure - Segments (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06121 - Disclosure - Segments (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:title="0602 - Disclosure - Summary of Significant Accounting Policies (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/StatementsOfComprehensiveLoss" xlink:title="0130 - Statement - Condensed Consolidated Statements of Comprehensive Loss (Unaudited)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_ComprehensiveIncomeNetOfTax"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ComprehensiveIncomeNetOfTax" xlink:to="loc_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" order="60" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ComprehensiveIncomeNetOfTax" xlink:to="loc_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_NetIncomeLossAvailableToCommonStockholdersBasic"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ComprehensiveIncomeNetOfTax" xlink:to="loc_NetIncomeLossAvailableToCommonStockholdersBasic" order="80" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicenses" xlink:title="0205 - Disclosure - Acquisitions, Investments, and Licenses"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CompositionOfCertainFinancialStatementCaptionsTables" xlink:title="0504 - Disclosure - Composition of Certain Financial Statement Captions (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails" xlink:title="0604 - Disclosure - Composition of Certain Financial Statement Captions (Details)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_AccountsReceivableNetCurrent"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_AllowanceForDoubtfulAccountsReceivableCurrent"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_AccountsReceivableNetCurrent" xlink:to="loc_AllowanceForDoubtfulAccountsReceivableCurrent" order="40" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_AccountsReceivableGrossCurrent"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_AccountsReceivableNetCurrent" xlink:to="loc_AccountsReceivableGrossCurrent" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_InventoryNet"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryValuationReserves" xlink:label="loc_InventoryValuationReserves"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_InventoryNet" xlink:to="loc_InventoryValuationReserves" order="80" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_InventoryRawMaterials"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_InventoryNet" xlink:to="loc_InventoryRawMaterials" order="60" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_InventoryWorkInProcess"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_InventoryNet" xlink:to="loc_InventoryWorkInProcess" order="40" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_InventoryFinishedGoods"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_InventoryNet" xlink:to="loc_InventoryFinishedGoods" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAndNoncurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrentAndNoncurrent"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrentAndNoncurrent" xlink:to="us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent" order="180" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrentAndNoncurrent" xlink:label="us-gaap_AccruedEmployeeBenefitsCurrentAndNoncurrent"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrentAndNoncurrent" xlink:label="us-gaap_AccruedProfessionalFeesCurrentAndNoncurrent"/> |
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| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_AccruedClinicalTrials" xlink:label="opk_AccruedClinicalTrials"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="us-gaap_DeferredRevenueCurrent"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent" xlink:label="loc_OtherLiabilitiesAndDeferredRevenueNoncurrent"/> |
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| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_MortgagesAndOtherDebtsPayable" xlink:label="opk_MortgagesAndOtherDebtsPayable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OtherLiabilitiesNoncurrent" xlink:to="opk_MortgagesAndOtherDebtsPayable" order="30" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="us-gaap_IntangibleAssetsNetExcludingGoodwill"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherFiniteLivedIntangibleAssetsGross" xlink:label="loc_OtherFiniteLivedIntangibleAssetsGross"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedNoncompeteAgreementsGross" xlink:label="loc_FiniteLivedNoncompeteAgreementsGross"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedTradeNamesGross" xlink:label="loc_FiniteLivedTradeNamesGross"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedPatentsGross" xlink:label="loc_FiniteLivedPatentsGross"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="loc_FiniteLivedPatentsGross" order="100" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedCustomerRelationshipsGross" xlink:label="loc_FiniteLivedCustomerRelationshipsGross"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="loc_FiniteLivedCustomerRelationshipsGross" order="140" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedComputerSoftwareGross" xlink:label="loc_FiniteLivedComputerSoftwareGross"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="loc_FiniteLivedComputerSoftwareGross" order="160" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_FiniteLivedIntangibleAssetsAccumulatedAmortization"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="loc_FiniteLivedIntangibleAssetsAccumulatedAmortization" order="20" use="optional" weight="-1" priority="1"/> |
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| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails" xlink:title="0606 - Disclosure - Debt (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetailsTextual" xlink:title="06065 - Disclosure - Debt (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetailsTextual" xlink:title="06093 - Disclosure - Derivative Contracts (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)"> </calculationLink> |
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| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical)"> </calculationLink> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" order="1.25" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" order="0.3125" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" order="0.15625" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" order="0.078125" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationCurrentAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" order="0.0390625" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" xlink:label="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" order="1.25" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionPurchasePricePatentsExpensed" xlink:label="opk_BusinessAcquisitionPurchasePricePatentsExpensed_2"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePricePatentsExpensed_2" order="21.25" use="optional" weight="1" priority="1"/> |
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| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/LossPerShareDetails" xlink:title="0603 - Disclosure - Loss Per Share (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AccumulatedOtherComprehensiveIncome" xlink:title="0207 - Disclosure - Accumulated Other Comprehensive Income"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurements" xlink:title="0208 - Disclosure - Fair Value Measurements"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails1" xlink:title="06061 - Disclosure - Debt (Details 1)"> </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AccumulatedOtherComprehensiveIncomeTables" xlink:title="0507 - Disclosure - Accumulated Other Comprehensive Income (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AccumulatedOtherComprehensivIncomeDetails" xlink:title="0607 - Disclosure - Accumulated Other Comprehensive Income (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SeriesDPreferredStockRedemption" xlink:title="0213 - Disclosure - Series D Preferred Stock Redemption"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="us-gaap_DebtInstrumentCarryingAmount"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="us-gaap_DebtInstrumentUnamortizedDiscount"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_DebtInstrumentCarryingAmount" xlink:to="us-gaap_DebtInstrumentUnamortizedDiscount" order="20" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="us-gaap_DebtInstrumentFaceAmount"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:label="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure"/> |
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| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:to="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGainLoss" order="20" use="optional" weight="1" priority="1"/> |
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| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:to="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1" order="10" use="optional" weight="-1" priority="1"/> |
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| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:to="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" order="5" use="optional" weight="1" priority="1"/> |
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