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Opko Health, Inc. – ‘10-Q’ for 3/31/13 – ‘EX-101.DEF’

On:  Friday, 5/10/13, at 11:12am ET   ·   For:  3/31/13   ·   Accession #:  1193125-13-212997   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 11/9/12 for 9/30/12   ·   Next:  ‘10-Q’ on 8/9/13 for 6/30/13   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23   ·   1 Reference:  By:  Opko Health, Inc. – ‘10-K’ on 2/18/21 for 12/31/20

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 5/10/13  Opko Health, Inc.                 10-Q        3/31/13   76:9.1M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    632K 
 2: EX-2.10     Plan of Acquisition, Reorganization, Arrangement,   HTML    369K 
                Liquidation or Succession                                        
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     21K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     21K 
52: R1          Document and Entity Information                     HTML     41K 
40: R2          Condensed Consolidated Balance Sheets (Unaudited)   HTML    147K 
50: R3          Condensed Consolidated Balance Sheets (Unaudited)   HTML     73K 
                (Parenthetical)                                                  
54: R4          Condensed Consolidated Statements of Operations     HTML    116K 
                (Unaudited)                                                      
70: R5          Condensed Consolidated Statements of Comprehensive  HTML     42K 
                Loss (Unaudited)                                                 
42: R6          Condensed Consolidated Statement of Shareholders'   HTML     95K 
                Equity (Unaudited)                                               
49: R7          Condensed Consolidated Statement of Shareholders'   HTML     25K 
                Equity (Unaudited) (Parenthetical)                               
36: R8          Condensed Consolidated Statements of Cash Flows     HTML    185K 
                (Unaudited)                                                      
27: R9          Business and Organization                           HTML     34K 
71: R10         Summary of Significant Accounting Policies          HTML     48K 
56: R11         Loss Per Share                                      HTML     28K 
55: R12         Composition of Certain Financial Statement          HTML     60K 
                Captions                                                         
61: R13         Acquisitions, Investments, and Licenses             HTML    107K 
62: R14         Debt                                                HTML     87K 
59: R15         Accumulated Other Comprehensive Income              HTML     37K 
63: R16         Fair Value Measurements                             HTML    158K 
51: R17         Derivative Contracts                                HTML     71K 
53: R18         Related Party Transactions                          HTML     40K 
58: R19         Commitments and Contingencies                       HTML     33K 
76: R20         Segments                                            HTML     68K 
66: R21         Series D Preferred Stock Redemption                 HTML     35K 
45: R22         Subsequent Events                                   HTML     25K 
57: R23         Summary of Significant Accounting Policies          HTML    119K 
                (Policies)                                                       
47: R24         Composition of Certain Financial Statement          HTML     59K 
                Captions (Tables)                                                
20: R25         Acquisitions, Investments, and Licenses (Tables)    HTML     95K 
67: R26         Debt (Tables)                                       HTML     86K 
73: R27         Accumulated Other Comprehensive Income (Tables)     HTML     32K 
31: R28         Fair Value Measurements (Tables)                    HTML    158K 
30: R29         Derivative Contracts (Tables)                       HTML     65K 
34: R30         Segments (Tables)                                   HTML     59K 
35: R31         Summary of Significant Accounting Policies          HTML     60K 
                (Details)                                                        
37: R32         Loss Per Share (Details)                            HTML     33K 
18: R33         Composition of Certain Financial Statement          HTML    124K 
                Captions (Details)                                               
64: R34         Acquisitions, Investments, and Licenses (Details)   HTML     43K 
44: R35         Acquisitions, Investments, and Licenses (Details    HTML     31K 
                1)                                                               
46: R36         Acquisitions, Investments, and Licenses (Details    HTML     67K 
                2)                                                               
23: R37         Acquisitions, Investments, and Licenses (Details    HTML     90K 
                3)                                                               
75: R38         Acquisitions, Investments, and Licenses (Details    HTML    193K 
                Textual)                                                         
13: R39         Debt (Details)                                      HTML     38K 
38: R40         Debt (Details 1)                                    HTML     27K 
69: R41         Debt (Details 2)                                    HTML     33K 
22: R42         Debt (Details 3)                                    HTML     53K 
29: R43         Debt (Details 4)                                    HTML     33K 
33: R44         Debt (Details Textual)                              HTML     86K 
41: R45         Accumulated Other Comprehensive Income (Details)    HTML     49K 
17: R46         Accumulated Other Comprehensive Income (Details     HTML     34K 
                Textual)                                                         
26: R47         Fair Value Measurements (Details)                   HTML     47K 
15: R48         Fair Value Measurements (Details 1)                 HTML     57K 
68: R49         Fair Value Measurements (Details 2)                 HTML     31K 
21: R50         Fair Value Measurements (Details 3)                 HTML     45K 
65: R51         Fair Value Measurements (Details Textual)           HTML     51K 
24: R52         Derivative Contracts (Details)                      HTML     30K 
39: R53         Derivative Contracts (Details 1)                    HTML     27K 
14: R54         Derivative Contracts (Details 2)                    HTML     38K 
16: R55         Derivative Contracts (Details Textual)              HTML     27K 
32: R56         Related Party Transactions (Details)                HTML    172K 
19: R57         Commitments and Contingencies (Details)             HTML     41K 
72: R58         Segments (Details)                                  HTML     67K 
43: R59         Segments (Details Textual)                          HTML     45K 
60: R60         Series D Preferred Stock Redemption (Details)       HTML     36K 
25: R61         Subsequent Events (Details)                         HTML     33K 
74: XML         IDEA XML File -- Filing Summary                      XML    113K 
28: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.36M 
 7: EX-101.INS  XBRL Instance -- opk-20130331                        XML   1.97M 
 9: EX-101.CAL  XBRL Calculations -- opk-20130331_cal                XML    231K 
10: EX-101.DEF  XBRL Definitions -- opk-20130331_def                 XML    978K 
11: EX-101.LAB  XBRL Labels -- opk-20130331_lab                      XML   1.51M 
12: EX-101.PRE  XBRL Presentations -- opk-20130331_pre               XML   1.14M 
 8: EX-101.SCH  XBRL Schema -- opk-20130331                          XSD    232K 
48: ZIP         XBRL Zipped Folder -- 0001193125-13-212997-xbrl      Zip    193K

‘EX-101.DEF’   —   XBRL Definitions — opk-20130331_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscount" xlink:label="opk_DeferredAcquisitionPaymentsNetOfDiscount"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_EquityMethodInvestmentNumberOfSharesPurchased" xlink:label="opk_EquityMethodInvestmentNumberOfSharesPurchased"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:label="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_NumberOfAncillaryTransaction" xlink:label="opk_NumberOfAncillaryTransaction"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationPotentialCashPayment" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionInterestHeldByThirdPartyInAcquireeSubsidiariesPercentage" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityCashPaid" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPreexistingRelationshipGainLossRecognized" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesReceivedUnderAssetPurchaseAgreement" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_EstimatedMilestonePaymentToBeReceived" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionSharePriceOnSharesIssue" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AmountPayableOnCashOrSharesOnAchievingMilestones" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_CommonStockParOrStatedValuePerShare" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_DeferredPaymentToSatisfyIndemnityClaims" order="16"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" order="17"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_StockIssuedDuringPeriodValueAcquisitions" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AncillaryTransactionDetails" order="19"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_EquityMethodInvestmentAmountOfFinancing" order="20"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_VariableInterestEntityOwnershipPercentage" order="21"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_DeferredAcquisitionPaymentsDiscount" order="22"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfTradingDays" order="23"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" order="24"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_LicenseAndServicesRevenue" order="25"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_EquityMethodInvestmentAmountOfSharesPurchased" order="26"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesIssuedUponAchievingCertainMilestone" order="27"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage" order="28"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPeriodForPaymentOfPurchasePriceToAcquireEntity" order="29"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_VariableInterestEntityOwnershipAmount" order="30"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesIssuedAtClosingDate" order="31"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" order="36"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_AdditionalPaidInCapital" order="38"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" order="42"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfAncillaryTransaction" order="43"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_CommonStockSharesIssued" order="44"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
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<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="2"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="us-gaap_EquityMethodInvesteeNameDomain" order="3"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" order="4"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:label="us-gaap_ScheduleOfCostMethodInvestmentsAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:to="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" order="5"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" xlink:title="06054 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="us-gaap_ProductOrServiceAxis"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ProductOrServiceAxis" xlink:to="us-gaap_ProductsAndServicesDomain" order="6"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="us-gaap_DebtInstrumentTable"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="us-gaap_ConvertibleNotesPayableMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DebtInstrumentAxis" xlink:to="us-gaap_DebtInstrumentNameDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain" xlink:to="us-gaap_ConvertibleNotesPayableMember" order="1"/>
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<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="us-gaap_DebtInstrumentTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="us-gaap_DebtInstrumentLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_DebtInstrumentLineItems" xlink:to="us-gaap_DebtInstrumentTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="us-gaap_DebtInstrumentLineItems"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="us-gaap_DebtInstrumentUnamortizedDiscount"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems" xlink:to="us-gaap_DebtInstrumentFaceAmount" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems" xlink:to="us-gaap_DebtInstrumentUnamortizedDiscount" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems" xlink:to="us-gaap_DebtInstrumentCarryingAmount" order="4"/>
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<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails2" xlink:title="06062 - Disclosure - Debt (Details 2)">
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<!-- Hypercube Definition (Line Items to Hypercube) -->
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="us-gaap_LineOfCreditFacilityTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="us-gaap_LineOfCreditFacilityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_LineOfCreditFacilityTable" xlink:to="us-gaap_LineOfCreditFacilityAxis" order="1"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails3" xlink:title="06063 - Disclosure - Debt (Details 3)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="us-gaap_LineOfCreditFacilityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="us-gaap_LineOfCreditFacilityLenderDomain"/>
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<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BankOfChileMember" xlink:label="opk_BankOfChileMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BiceBankMember" xlink:label="opk_BiceBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_CorpBancaMember" xlink:label="opk_CorpBancaMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BbvaBankMember" xlink:label="opk_BbvaBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PentaBankMember" xlink:label="opk_PentaBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SecurityMember" xlink:label="opk_SecurityMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BciMember" xlink:label="opk_BciMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_EstadoBankMember" xlink:label="opk_EstadoBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SabadellBankMember" xlink:label="opk_SabadellBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BilbaoVizcayaBankMember" xlink:label="opk_BilbaoVizcayaBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BancoPopularMember" xlink:label="opk_BancoPopularMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SantanderBankMember" xlink:label="opk_SantanderBankMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BanestoMember" xlink:label="opk_BanestoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BancaMarchMember" xlink:label="opk_BancaMarchMember"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_ItauBankMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BankOfChileMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BiceBankMember" order="3"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_PentaBankMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_SecurityMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BciMember" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_EstadoBankMember" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_SabadellBankMember" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BilbaoVizcayaBankMember" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BancoPopularMember" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_SantanderBankMember" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BanestoMember" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLenderDomain" xlink:to="opk_BancaMarchMember" order="15"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="us-gaap_LineOfCreditFacilityTable"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LineOfCreditFacilityTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="us-gaap_LineOfCreditFacilityLineItems"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumAmountOutstandingDuringPeriod" xlink:label="us-gaap_LineOfCreditFacilityMaximumAmountOutstandingDuringPeriod"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LinesOfCreditCurrent" xlink:label="us-gaap_LinesOfCreditCurrent"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LineOfCreditFacilityMaximumAmountOutstandingDuringPeriod" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LinesOfCreditCurrent" order="4"/>
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<!-- Dimension Defaults -->
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="us-gaap_LineOfCreditFacilityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="us-gaap_LineOfCreditFacilityLenderDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_LineOfCreditFacilityAxis" xlink:to="us-gaap_LineOfCreditFacilityLenderDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails4" xlink:title="06064 - Disclosure - Debt (Details 4)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="us-gaap_LineOfCreditFacilityTable"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_LineOfCreditFacilityTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails4" xlink:title="06064 - Disclosure - Debt (Details 4)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_FarmadietAcquisitionMember" xlink:label="opk_FarmadietAcquisitionMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_FarmadietAcquisitionMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails4" xlink:title="06064 - Disclosure - Debt (Details 4)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="us-gaap_LineOfCreditFacilityTable"/>
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</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:LineOfCreditFacilityLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails4" xlink:title="06064 - Disclosure - Debt (Details 4)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems" xlink:label="us-gaap_LineOfCreditFacilityLineItems"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebt" xlink:label="us-gaap_LongTermDebt"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LongTermDebtCurrent" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LongTermDebtNoncurrent" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LineOfCreditFacilityLineItems" xlink:to="us-gaap_LongTermDebt" order="4"/>
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<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetails4" xlink:title="06064 - Disclosure - Debt (Details 4)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetailsTextual" xlink:title="06065 - Disclosure - Debt (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityTable" xlink:label="us-gaap_LineOfCreditFacilityTable"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_LineOfCreditFacilityTable" xlink:to="us-gaap_DerivativeInstrumentRiskAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetailsTextual" xlink:title="06065 - Disclosure - Debt (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="us-gaap_DerivativeInstrumentRiskAxis"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="us-gaap_ForwardContractsMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="us-gaap_ConvertibleNotesPayableMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_NotesAndForwardContractsMember" xlink:label="opk_NotesAndForwardContractsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DerivativeInstrumentRiskAxis" xlink:to="us-gaap_DerivativeContractTypeDomain" order="1"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="us-gaap_ForwardContractsMember" order="2"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_NotesAndForwardContractsMember" order="4"/>
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<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetailsTextual" xlink:title="06065 - Disclosure - Debt (Details Textual)">
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_LineOfCreditFacilityTable" xlink:to="us-gaap_LongtermDebtTypeAxis" order="2"/>
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<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DebtDetailsTextual" xlink:title="06065 - Disclosure - Debt (Details Textual)">
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<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ManagementTwoMember" xlink:label="opk_ManagementTwoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ManagementFourMember" xlink:label="opk_ManagementFourMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_GammaTrustMember" xlink:label="opk_GammaTrustMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_HsuGammaMember" xlink:label="opk_HsuGammaMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SorrentoMember" xlink:label="opk_SorrentoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_RealEstateHoldingsLlcMember" xlink:label="opk_RealEstateHoldingsLlcMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_FabrusIncMember" xlink:label="opk_FabrusIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_DrFrostMember" xlink:label="opk_DrFrostMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_MrPregoNovoMember" xlink:label="opk_MrPregoNovoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ChromaDexMember" xlink:label="opk_ChromaDexMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_DrLernerMember" xlink:label="opk_DrLernerMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_AviPropertiesLlcMember" xlink:label="opk_AviPropertiesLlcMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ScrippsResearchInstituteMember" xlink:label="opk_ScrippsResearchInstituteMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_TevaPharmaceuticalIndustriesMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ManagementTwoMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ManagementFourMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_GammaTrustMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_HsuGammaMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_SorrentoMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_RealEstateHoldingsLlcMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_FabrusIncMember" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_DrFrostMember" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_MrPregoNovoMember" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ChromaDexMember" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_DrLernerMember" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_AviPropertiesLlcMember" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ScrippsResearchInstituteMember" order="14"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="us-gaap_ClassificationOfVariableInterestEntityDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ChromadexCorporationMember" xlink:label="opk_ChromadexCorporationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_AeroPharmaceuticalsIncMember" xlink:label="opk_AeroPharmaceuticalsIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="opk_BiozonePharmaceuticalsIncMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="us-gaap_ClassificationOfVariableInterestEntityDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="opk_ChromadexCorporationMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="opk_AeroPharmaceuticalsIncMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="opk_BiozonePharmaceuticalsIncMember" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="us-gaap_RelatedPartyTransactionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" order="3" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:RelatedPartyTransactionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="us-gaap_RelatedPartyTransactionLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_RelatedPartyTransactionsTextualAbstract" xlink:label="opk_RelatedPartyTransactionsTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_TermOfLease" xlink:label="opk_TermOfLease"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="us-gaap_LeaseAndRentalExpense"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AreaOfLand" xlink:label="us-gaap_AreaOfLand"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PercentageIncreaseInConsumerPriceIndex" xlink:label="opk_PercentageIncreaseInConsumerPriceIndex"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ResearchFundingAndOptionAgreementAnnualAmount" xlink:label="opk_ResearchFundingAndOptionAgreementAnnualAmount"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ResearchFundingAndOptionAgreementPeriodOfPayment" xlink:label="opk_ResearchFundingAndOptionAgreementPeriodOfPayment"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_LeaseExtendedPeriod" xlink:label="opk_LeaseExtendedPeriod"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="us-gaap_SalesRevenueNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="us-gaap_EquityMethodInvestments"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_OwnershipPercentageHeldByMembers" xlink:label="opk_OwnershipPercentageHeldByMembers"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_OwnershipPercentageHeld" xlink:label="opk_OwnershipPercentageHeld"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="us-gaap_DebtInstrumentFaceAmount"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_WarrantsToPurchaseCommonShares" xlink:label="opk_WarrantsToPurchaseCommonShares"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" xlink:label="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PromissoryNotesMaturityDate" xlink:label="opk_PromissoryNotesMaturityDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_WarrantsDuration" xlink:label="opk_WarrantsDuration"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_LoanToBzne" xlink:label="opk_LoanToBzne"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_MaximumOwnershipPercentageHeldByMembers" xlink:label="opk_MaximumOwnershipPercentageHeldByMembers"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="us-gaap_VariableInterestEntityOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_FinancingForVariableInterestEntities" xlink:label="opk_FinancingForVariableInterestEntities"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_OwnershipPercentageHeldByDirector" xlink:label="opk_OwnershipPercentageHeldByDirector"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_OutstandingCommonSharesAcquired" xlink:label="opk_OutstandingCommonSharesAcquired"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_LeaseRentPerMonthForFirstYear" xlink:label="opk_LeaseRentPerMonthForFirstYear"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_LeaseRentPerMonthForFifthYear" xlink:label="opk_LeaseRentPerMonthForFifthYear"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_CreditForTenantImprovements" xlink:label="opk_CreditForTenantImprovements"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" xlink:label="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_TermOfLease" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LeaseAndRentalExpense" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_AreaOfLand" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_PercentageIncreaseInConsumerPriceIndex" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_ResearchFundingAndOptionAgreementAnnualAmount" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_ResearchFundingAndOptionAgreementPeriodOfPayment" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseExtendedPeriod" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_SalesRevenueNet" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_EquityMethodInvestments" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeldByMembers" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeld" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_DebtInstrumentInterestRateStatedPercentage" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_DebtInstrumentFaceAmount" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_WarrantsToPurchaseCommonShares" order="16"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" order="17"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_PromissoryNotesMaturityDate" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_WarrantsDuration" order="19"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_CommonStockSharesIssued" order="20"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage" order="21"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LoanToBzne" order="22"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_MaximumOwnershipPercentageHeldByMembers" order="23"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" order="24"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_VariableInterestEntityOwnershipPercentage" order="25"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_FinancingForVariableInterestEntities" order="26"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeldByDirector" order="27"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OutstandingCommonSharesAcquired" order="28"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseRentPerMonthForFirstYear" order="29"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseRentPerMonthForFifthYear" order="30"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_CreditForTenantImprovements" order="31"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" order="32"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0610 - Disclosure - Related Party Transactions (Details)">
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfStockByClassTable" xlink:to="us-gaap_StatementClassOfStockAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SeriesDPreferredStockRedemptionDetails" xlink:title="0613 - Disclosure - Series D Preferred Stock Redemption (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="us-gaap_SeriesDPreferredStockMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_SeriesDPreferredStockMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SeriesDPreferredStockRedemptionDetails" xlink:title="0613 - Disclosure - Series D Preferred Stock Redemption (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="us-gaap_ScheduleOfStockByClassTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="us-gaap_ClassOfStockLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ClassOfStockLineItems" xlink:to="us-gaap_ScheduleOfStockByClassTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:ClassOfStockLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SeriesDPreferredStockRedemptionDetails" xlink:title="0613 - Disclosure - Series D Preferred Stock Redemption (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="us-gaap_ClassOfStockLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SeriesDPreferredStockRedemptionTextualAbstract" xlink:label="opk_SeriesDPreferredStockRedemptionTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="us-gaap_DividendsPreferredStockCash"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConversionOfStockSharesConverted1" xlink:label="us-gaap_ConversionOfStockSharesConverted1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConversionOfStockSharesIssued1" xlink:label="us-gaap_ConversionOfStockSharesIssued1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="us-gaap_PreferredStockSharesOutstanding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems" xlink:to="us-gaap_DividendsPreferredStockCash" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems" xlink:to="us-gaap_ConversionOfStockSharesConverted1" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems" xlink:to="us-gaap_ConversionOfStockSharesIssued1" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems" xlink:to="us-gaap_PreferredStockSharesOutstanding" order="5"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SeriesDPreferredStockRedemptionDetails" xlink:title="0613 - Disclosure - Series D Preferred Stock Redemption (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEventsDetails" xlink:title="0614 - Disclosure - Subsequent Events (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="us-gaap_SubsequentEventTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_SubsequentEventTable" xlink:to="us-gaap_SubsequentEventTypeAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEventsDetails" xlink:title="0614 - Disclosure - Subsequent Events (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="us-gaap_SubsequentEventMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_SubsequentEventTypeAxis" xlink:to="us-gaap_SubsequentEventTypeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventTypeDomain" xlink:to="us-gaap_SubsequentEventMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEventsDetails" xlink:title="0614 - Disclosure - Subsequent Events (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="us-gaap_SubsequentEventTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="us-gaap_SubsequentEventLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="us-gaap_SubsequentEventTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:SubsequentEventLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEventsDetails" xlink:title="0614 - Disclosure - Subsequent Events (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="us-gaap_SubsequentEventLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_SubsequentEventTextualAbstract" xlink:label="opk_SubsequentEventTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionShareExchangeRatio" xlink:label="opk_BusinessAcquisitionShareExchangeRatio"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionSharePrice" xlink:label="us-gaap_BusinessAcquisitionSharePrice"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_BusinessAcquisitionSharePriceOfAcquiree" xlink:label="opk_BusinessAcquisitionSharePriceOfAcquiree"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PercentageOfShareholdingByChairmanOfAcquireeCompany" xlink:label="opk_PercentageOfShareholdingByChairmanOfAcquireeCompany"/>
<link:loc xlink:type="locator" xlink:href="opk-20130331.xsd#opk_PercentageOfShareholdingByDirectorsOfAcquireeCompany" xlink:label="opk_PercentageOfShareholdingByDirectorsOfAcquireeCompany"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="opk_BusinessAcquisitionShareExchangeRatio" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="us-gaap_BusinessAcquisitionSharePrice" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="opk_BusinessAcquisitionSharePriceOfAcquiree" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="opk_PercentageOfShareholdingByChairmanOfAcquireeCompany" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems" xlink:to="opk_PercentageOfShareholdingByDirectorsOfAcquireeCompany" order="7"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEventsDetails" xlink:title="0614 - Disclosure - Subsequent Events (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_SubsequentEventTypeAxis" xlink:to="us-gaap_SubsequentEventTypeDomain" order="1"/>
</link:definitionLink>
</link:linkbase>

1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
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