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Opko Health, Inc. – ‘10-K’ for 12/31/12 – ‘EX-101.SCH’

On:  Monday, 3/18/13, at 4:30pm ET   ·   For:  12/31/12   ·   Accession #:  1193125-13-112598   ·   File #:  1-33528

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/18/13  Opko Health, Inc.                 10-K       12/31/12  111:15M                                    Donnelley … Solutions/FA

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.37M 
 2: EX-2.9      Plan of Acquisition, Reorganization, Arrangement,   HTML    225K 
                Liquidation or Succession                                        
 3: EX-21       Subsidiaries List                                   HTML     28K 
 4: EX-23.1     Consent of Experts or Counsel                       HTML     29K 
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     34K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     34K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     29K 
 8: EX-32.2     Certification -- §906 - SOA'02                      HTML     28K 
75: R1          Document and Entity Information                     HTML     57K 
59: R2          Consolidated Balance Sheets                         HTML    152K 
71: R3          Consolidated Balance Sheets (Parenthetical)         HTML     82K 
79: R4          Consolidated Statements of Operations               HTML    147K 
101: R5          Consolidated Statements of Comprehensive Loss       HTML     50K  
61: R6          Consolidated Statements of Shareholders' Equity     HTML    187K 
70: R7          Consolidated Statements of Shareholders' Equity     HTML     37K 
                (Parenthetical)                                                  
53: R8          Consolidated Statements of Cash Flows               HTML    188K 
43: R9          Business and Organization                           HTML     40K 
103: R10         Summary of Significant Accounting Policies          HTML     62K  
81: R11         Acquisitions, Investments, and Licenses             HTML    161K 
80: R12         Discontinued Operations                             HTML     53K 
87: R13         Composition of Certain Financial Statement          HTML    150K 
                Captions                                                         
88: R14         Debt                                                HTML     59K 
85: R15         Equity Offerings                                    HTML     39K 
89: R16         Shareholders' Equity                                HTML     60K 
72: R17         Equity-Based Compensation                           HTML     69K 
76: R18         Income Taxes                                        HTML    109K 
83: R19         Supplemental Cash Flow Information                  HTML     52K 
111: R20         Related Party Transactions                          HTML     48K  
97: R21         Employee Benefit Plans                              HTML     38K 
66: R22         Commitments and Contingencies                       HTML     38K 
82: R23         Strategic Alliances                                 HTML     30K 
68: R24         Leases                                              HTML     40K 
34: R25         Segments                                            HTML     93K 
98: R26         Fair Value Measurement                              HTML    129K 
107: R27         Derivative Contracts                                HTML     64K  
48: R28         Selected Quarterly Financial Data (Unaudited)       HTML     66K 
47: R29         Subsequent Events                                   HTML     39K 
51: R30         Summary of Significant Accounting Policies          HTML    157K 
                (Policies)                                                       
52: R31         Acquisitions, Investments, and Licenses (Tables)    HTML    142K 
54: R32         Discontinued Operations (Tables)                    HTML     48K 
22: R33         Composition of Certain Financial Statement          HTML    156K 
                Captions (Tables)                                                
95: R34         Debt (Tables)                                       HTML     56K 
64: R35         Equity Offerings (Tables)                           HTML     39K 
67: R36         Shareholders' Equity (Tables)                       HTML     40K 
38: R37         Equity-Based Compensation (Tables)                  HTML     61K 
110: R38         Income Taxes (Tables)                               HTML    106K  
15: R39         Supplemental Cash Flow Information (Tables)         HTML     49K 
56: R40         Leases (Tables)                                     HTML     35K 
100: R41         Segments (Tables)                                   HTML     84K  
36: R42         Fair Value Measurement (Tables)                     HTML    126K 
46: R43         Derivative Contracts (Tables)                       HTML     52K 
50: R44         Selected Quarterly Financial Data (Unaudited)       HTML     61K 
                (Tables)                                                         
60: R45         Summary of Significant Accounting Policies          HTML    121K 
                (Details)                                                        
21: R46         Acquisitions, Investments, and Licenses (Details)   HTML     80K 
42: R47         Acquisitions, Investments, and Licenses (Details    HTML     67K 
                1)                                                               
17: R48         Acquisitions, Investments, and Licenses (Details    HTML     58K 
                2)                                                               
99: R49         Acquisitions, Investments, and Licenses (Details    HTML     61K 
                3)                                                               
35: R50         Acquisitions, Investments, and Licenses (Details    HTML     42K 
                4)                                                               
96: R51         Acquisitions, Investments, and Licenses (Details    HTML     92K 
                5)                                                               
39: R52         Acquisitions, Investments and Licenses (Details 6)  HTML     52K 
57: R53         Acquisitions, Investments and Licenses (Details 7)  HTML     77K 
16: R54         Acquisitions, Investments, and Licenses (Details    HTML    407K 
                Textual)                                                         
19: R55         Discontinued Operations (Details)                   HTML     43K 
49: R56         Discontinued Operations (Details 1)                 HTML     48K 
26: R57         Discontinued Operations (Details Textual)           HTML     33K 
104: R58         Composition of Certain Financial Statement          HTML    192K  
                Captions (Details)                                               
63: R59         Composition of Certain Financial Statement          HTML     58K 
                Captions (Details 1)                                             
86: R60         Composition of Certain Financial Statement          HTML     44K 
                Captions (Details 2)                                             
41: R61         Debt (Details)                                      HTML     67K 
44: R62         Debt (Details Textual)                              HTML     49K 
93: R63         Equity Offerings (Details)                          HTML     54K 
90: R64         Equity Offerings (Details Textual)                  HTML     53K 
65: R65         Shareholders' Equity (Details)                      HTML     51K 
92: R66         Shareholders' Equity (Details Textual)              HTML    107K 
40: R67         Equity-Based Compensation (Details)                 HTML     50K 
69: R68         Equity-Based Compensation (Details 1)               HTML     89K 
106: R69         Equity-Based Compensation (Details 2)               HTML     50K  
18: R70         Equity-Based Compensation (Details Textual)         HTML     78K 
33: R71         Income Taxes (Details)                              HTML     75K 
58: R72         Income Taxes (Details 1)                            HTML     84K 
24: R73         Income Taxes (Details 2)                            HTML     38K 
109: R74         Income Taxes (Details 3)                            HTML     52K  
37: R75         Income Taxes (Details 4)                            HTML     37K 
28: R76         Income Taxes (Details 5)                            HTML     34K 
32: R77         Income Taxes (Details Textual)                      HTML     68K 
20: R78         Supplemental Cash Flow Information (Details)        HTML     50K 
23: R79         Related Party Transactions (Details)                HTML    246K 
77: R80         Employee Benefit Plans (Details)                    HTML     36K 
30: R81         Commitments and Contingencies (Details)             HTML     46K 
105: R82         Leases (Details)                                    HTML     55K  
55: R83         Leases (Details Textual)                            HTML     30K 
84: R84         Segments (Details)                                  HTML    101K 
91: R85         Segments (Details Textual)                          HTML     37K 
29: R86         Fair Value Measurement (Details)                    HTML     53K 
31: R87         Fair Value Measurement (Details 1)                  HTML     60K 
102: R88         Fair Value Measurement (Details 2)                  HTML     52K  
25: R89         Fair Value Measurement (Details Textual)            HTML     54K 
78: R90         Derivative Contracts (Details)                      HTML     45K 
74: R91         Derivative Contracts (Details Textual)              HTML     31K 
94: R92         Selected Quarterly Financial Data (Unaudited)       HTML     87K 
                (Details)                                                        
73: R93         Selected Quarterly Financial Data (Unaudited)       HTML     34K 
                (Details Textual)                                                
62: R94         Subsequent Events (Details)                         HTML     79K 
108: XML         IDEA XML File -- Filing Summary                      XML    169K  
45: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   2.46M 
 9: EX-101.INS  XBRL Instance -- opk-20121231                        XML   3.12M 
11: EX-101.CAL  XBRL Calculations -- opk-20121231_cal                XML    389K 
12: EX-101.DEF  XBRL Definitions -- opk-20121231_def                 XML   1.34M 
13: EX-101.LAB  XBRL Labels -- opk-20121231_lab                      XML   2.25M 
14: EX-101.PRE  XBRL Presentations -- opk-20121231_pre               XML   1.77M 
10: EX-101.SCH  XBRL Schema -- opk-20121231                          XSD    325K 
27: ZIP         XBRL Zipped Folder -- 0001193125-13-112598-xbrl      Zip    283K

‘EX-101.SCH’   —   XBRL Schema — opk-20121231

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:definition> 06183 - Disclosure - Fair Value Measurement (Details Textual) </link:definition>
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<link:definition> 0618 - Disclosure - Fair Value Measurement (Details) </link:definition>
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<link:definition> 0511 - Disclosure - Supplemental Cash Flow Information (Tables) </link:definition>
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<link:definition> 0508 - Disclosure - Shareholders' Equity (Tables) </link:definition>
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</link:roleType>
<link:roleType roleURI="http://opko.com/role/ShareholdersEquityDetailsTextual" id="ShareholdersEquityDetailsTextual">
<link:definition> 06081 - Disclosure - Shareholders' Equity (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/ShareholdersEquityDetails" id="ShareholdersEquityDetails">
<link:definition> 0608 - Disclosure - Shareholders' Equity (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EquityOfferingsDetailsTextual" id="EquityOfferingsDetailsTextual">
<link:definition> 06071 - Disclosure - Equity Offerings (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EquityOfferingsDetails" id="EquityOfferingsDetails">
<link:definition> 0607 - Disclosure - Equity Offerings (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EquityOfferingsTables" id="EquityOfferingsTables">
<link:definition> 0507 - Disclosure - Equity Offerings (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DebtDetailsTextual" id="DebtDetailsTextual">
<link:definition> 06061 - Disclosure - Debt (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DebtDetails" id="DebtDetails">
<link:definition> 0606 - Disclosure - Debt (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
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<link:definition> 06052 - Disclosure - Composition of Certain Financial Statement Captions (Details 2) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails1" id="CompositionOfCertainFinancialStatementCaptionsDetails1">
<link:definition> 06051 - Disclosure - Composition of Certain Financial Statement Captions (Details 1) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails5" id="AcquisitionsInvestmentsAndLicensesDetails5">
<link:definition> 06035 - Disclosure - Acquisitions, Investments, and Licenses (Details 5) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails4" id="AcquisitionsInvestmentsAndLicensesDetails4">
<link:definition> 06034 - Disclosure - Acquisitions, Investments, and Licenses (Details 4) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails3" id="AcquisitionsInvestmentsAndLicensesDetails3">
<link:definition> 06033 - Disclosure - Acquisitions, Investments, and Licenses (Details 3) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SelectedQuarterlyFinancialData" id="SelectedQuarterlyFinancialData">
<link:definition> 0220 - Disclosure - Selected Quarterly Financial Data (Unaudited) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/Leases" id="Leases">
<link:definition> 0216 - Disclosure - Leases </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/StrategicAlliances" id="StrategicAlliances">
<link:definition> 0215 - Disclosure - Strategic Alliances </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EmployeeBenefitPlans" id="EmployeeBenefitPlans">
<link:definition> 0213 - Disclosure - Employee Benefit Plans </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SupplementalCashFlowInformation" id="SupplementalCashFlowInformation">
<link:definition> 0211 - Disclosure - Supplemental Cash Flow Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/IncomeTaxes" id="IncomeTaxes">
<link:definition> 0210 - Disclosure - Income Taxes </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EquityBasedCompensation" id="EquityBasedCompensation">
<link:definition> 0209 - Disclosure - Equity-Based Compensation </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/ShareholdersEquity" id="ShareholdersEquity">
<link:definition> 0208 - Disclosure - Shareholders' Equity </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/EquityOfferings" id="EquityOfferings">
<link:definition> 0207 - Disclosure - Equity Offerings </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/Debt" id="Debt">
<link:definition> 0206 - Disclosure - Debt </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptionsDetails" id="CompositionOfCertainFinancialStatementCaptionsDetails">
<link:definition> 0605 - Disclosure - Composition of Certain Financial Statement Captions (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptionsTables" id="CompositionOfCertainFinancialStatementCaptionsTables">
<link:definition> 0505 - Disclosure - Composition of Certain Financial Statement Captions (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/RelatedPartyTransactionsDetails" id="RelatedPartyTransactionsDetails">
<link:definition> 0612 - Disclosure - Related Party Transactions (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" id="AcquisitionsInvestmentsAndLicensesTables">
<link:definition> 0503 - Disclosure - Acquisitions, Investments, and Licenses (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicenses" id="AcquisitionsInvestmentsAndLicenses">
<link:definition> 0203 - Disclosure - Acquisitions, Investments, and Licenses </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/StatementsOfComprehensiveLoss" id="StatementsOfComprehensiveLoss">
<link:definition> 0130 - Statement - Consolidated Statements of Comprehensive Loss </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SummaryOfSignificantAccountingPoliciesDetails" id="SummaryOfSignificantAccountingPoliciesDetails">
<link:definition> 0602 - Disclosure - Summary of Significant Accounting Policies (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SegmentsDetailsTextual" id="SegmentsDetailsTextual">
<link:definition> 06171 - Disclosure - Segments (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SegmentsDetails" id="SegmentsDetails">
<link:definition> 0617 - Disclosure - Segments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" id="CommitmentsAndContingenciesDetailsTextual">
<link:definition> 0614 - Disclosure - Commitments and Contingencies (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DerivativeContractsDetails" id="DerivativeContractsDetails">
<link:definition> 0619 - Disclosure - Derivative Contracts (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DiscontinuedOperationsDetailsTextual" id="DiscontinuedOperationsDetailsTextual">
<link:definition> 06042 - Disclosure - Discontinued Operations (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DiscontinuedOperationsDetails1" id="DiscontinuedOperationsDetails1">
<link:definition> 06041 - Disclosure - Discontinued Operations (Details 1) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DiscontinuedOperationsDetails" id="DiscontinuedOperationsDetails">
<link:definition> 0604 - Disclosure - Discontinued Operations (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/AcquisitionsAndInvestmentsDetailsTextual" id="AcquisitionsAndInvestmentsDetailsTextual">
<link:definition> 06038 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/SegmentsTables" id="SegmentsTables">
<link:definition> 0517 - Disclosure - Segments (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DerivativeContractsTables" id="DerivativeContractsTables">
<link:definition> 0519 - Disclosure - Derivative Contracts (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/DiscontinuedOperationsTables" id="DiscontinuedOperationsTables">
<link:definition> 0504 - Disclosure - Discontinued Operations (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies" id="SummaryOfSignificantAccountingPoliciesPolicies">
<link:definition> 0402 - Disclosure - Summary of Significant Accounting Policies (Policies) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
<link:definition> 00 - Document - Document and Entity Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/BalanceSheets" id="BalanceSheets">
<link:definition> 0110 - Statement - Consolidated Balance Sheets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/StatementsOfOperations" id="StatementsOfOperations">
<link:definition> 0120 - Statement - Consolidated Statements of Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://opko.com/role/StatementsOfCashFlows" id="StatementsOfCashFlows">
<link:definition> 0150 - Statement - Consolidated Statements of Cash Flows </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/BusinessAndOrganization" id="BusinessAndOrganization">
<link:definition> 0201 - Disclosure - Business and Organization </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/SummaryOfSignificantAccountingPolicies" id="SummaryOfSignificantAccountingPolicies">
<link:definition> 0202 - Disclosure - Summary of Significant Accounting Policies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptions" id="CompositionOfCertainFinancialStatementCaptions">
<link:definition> 0205 - Disclosure - Composition of Certain Financial Statement Captions </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/DiscontinuedOperations" id="DiscontinuedOperations">
<link:definition> 0204 - Disclosure - Discontinued Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/DerivativeContracts" id="DerivativeContracts">
<link:definition> 0219 - Disclosure - Derivative Contracts </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/RelatedPartyTransactions" id="RelatedPartyTransactions">
<link:definition> 0212 - Disclosure - Related Party Transactions </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://opko.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies">
<link:definition> 0214 - Disclosure - Commitments and Contingencies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0217 - Disclosure - Segments </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 0221 - Disclosure - Subsequent Events </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<element id="opk_SorrentoMember" name="SorrentoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CocrystalMember" name="CocrystalMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FabrusMember" name="FabrusMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TesaroMember" name="TesaroMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NeovascMember" name="NeovascMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_ZeroToThirtyMember" name="ZeroToThirtyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ThirtyOneToSixtyMember" name="ThirtyOneToSixtyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SixtyOneToNinetyMember" name="SixtyOneToNinetyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NinetyOneToOneHundredTwentyMember" name="NinetyOneToOneHundredTwentyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OneHundredTwentyOneToOneHundredEightyMember" name="OneHundredTwentyOneToOneHundredEightyMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_GammaTrustMember" name="GammaTrustMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_TimeOfTransactionPercentageOwned" name="TimeOfTransactionPercentageOwned" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_LicensingFeesPreviouslyPaid" name="LicensingFeesPreviouslyPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_LicensingFeesPaid" name="LicensingFeesPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ReimbursementOfCertainExpenses" name="ReimbursementOfCertainExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
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<element id="opk_CommitmentsAndContingenciesTextualAbstract" name="CommitmentsAndContingenciesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" name="CompositionOfCertainFinancialStatementCaptionsTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_VariableInterestEntityEntityAccumulatedLossesInInvestees" name="VariableInterestEntityEntityAccumulatedLossesInInvestees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_VariableInterestEntityEntityMaximumNetLossExposureAmount" name="VariableInterestEntityEntityMaximumNetLossExposureAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
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<element id="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" name="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" name="NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
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<element id="opk_OwnershipPercentageOfVariablesInterestEntity" name="OwnershipPercentageOfVariablesInterestEntity" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_CocrystalDiscoveryIncMember" name="CocrystalDiscoveryIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_OwnershipPercentageHeldByMembers" name="OwnershipPercentageHeldByMembers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_ManagementTwoMember" name="ManagementTwoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementFourMember" name="ManagementFourMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OwnershipPercentageHeldByDirector" name="OwnershipPercentageHeldByDirector" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ResearchAndDevelopmentAgreementAmountForPeriod" name="ResearchAndDevelopmentAgreementAmountForPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
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<element id="opk_AdditionalInvestmentByGroupOfInvestor" name="AdditionalInvestmentByGroupOfInvestor" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
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<element id="opk_LeaseRentPerMonthForFirstYear" name="LeaseRentPerMonthForFirstYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_CreditForTenantImprovements" name="CreditForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ReimbursementPaidToRelatedPartyForTravel" name="ReimbursementPaidToRelatedPartyForTravel" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_LeaseRentPerMonthForFifthYear" name="LeaseRentPerMonthForFifthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" name="ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AccountsReceivableFromMajorCustomer" name="AccountsReceivableFromMajorCustomer" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" name="MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfYearsOverWhichRevenueWillBeRecognized" name="NumberOfYearsOverWhichRevenueWillBeRecognized" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" name="MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PercentageInBoardOfManagers" name="PercentageInBoardOfManagers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_InvestmentInVariableInterestEntities" name="InvestmentInVariableInterestEntities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_NumberOfLicenseAgreements" name="NumberOfLicenseAgreements" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_NumberOfOperatingSegment" name="NumberOfOperatingSegment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_GammaTrustAndHsuGammaMember" name="GammaTrustAndHsuGammaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" name="NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_OutstandingCommonSharesAcquired" name="OutstandingCommonSharesAcquired" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfEqualInstallmentsPayableForAdditionalInvestment" name="NumberOfEqualInstallmentsPayableForAdditionalInvestment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_RevenueFromReceiptOfEquity" name="RevenueFromReceiptOfEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
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<element id="opk_FinetechAcquisitionMember" name="FinetechAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" name="BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationTradeName" name="BusinessAcquisitionPurchasePriceAllocationTradeName" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
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<element id="opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" name="BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_AverageClosingSalesPricePerShareOfCommonStock" name="AverageClosingSalesPricePerShareOfCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_FabrusAndDrsFrostMember" name="FabrusAndDrsFrostMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_HsiaoAndLernerMember" name="HsiaoAndLernerMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ValueOfStockConsiderationHeldInEscrowAccount" name="ValueOfStockConsiderationHeldInEscrowAccount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_WarrantsDuration" name="WarrantsDuration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_UnrealizedGainOnWarrants" name="UnrealizedGainOnWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchaseOfSeriesPreferredStock" name="BusinessAcquisitionPurchaseOfSeriesPreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DiscontinuedOperationsMember" name="DiscontinuedOperationsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" name="EffectOfLossOnForeignCurrencyDerivativeBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ClaimAgainstEscrowForUndisclosedLiabilities" name="ClaimAgainstEscrowForUndisclosedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_NeovascOptionsMember" name="NeovascOptionsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FabrusIncMember" name="FabrusIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfCustomerRepresentation" name="NumberOfCustomerRepresentation" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_UnrealizedGainOnInvestmentsOptionsAndWarrants" name="UnrealizedGainOnInvestmentsOptionsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_NumberOfTradingDays" name="NumberOfTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AccruedClinicalTrials" name="AccruedClinicalTrials" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" name="BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
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<element id="opk_PharmacosExaktaMember" name="PharmacosExaktaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FineTechMember" name="FineTechMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ExerciseOfCommonStockWarrantsShares" name="ExerciseOfCommonStockWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PurchasePriceAdjustment" name="PurchasePriceAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_IssuanceOfCommonStockInPrivatePlacementIncludingRelatedPartiesPerShare" name="IssuanceOfCommonStockInPrivatePlacementIncludingRelatedPartiesPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_StockRepurchasedDuringPeriodPerShare" name="StockRepurchasedDuringPeriodPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_IssuanceOfCommonStockPerShare" name="IssuanceOfCommonStockPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RepaymentsOfLinesOfCreditAndCapitalLeaseObligations" name="RepaymentsOfLinesOfCreditAndCapitalLeaseObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_EquityOfferingsTextBlock" name="EquityOfferingsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_StrategicAlliancesAbstract" name="StrategicAlliancesAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_StrategicAlliancesTextBlock" name="StrategicAlliancesTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ExerciseOfCommonStockWarrantsToPurchaseShares" name="ExerciseOfCommonStockWarrantsToPurchaseShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DeferredRevenueRelatedToOtherRevenues" name="DeferredRevenueRelatedToOtherRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_ProFormaResultOfCombinedCompaniesTableTextBlock" name="ProFormaResultOfCombinedCompaniesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OpkoChileMember" name="OpkoChileMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityContingentConsideration" name="BusinessAcquisitionCostOfAcquiredEntityContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_PaymentsUnderLicenseAgreements" name="PaymentsUnderLicenseAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LicenseAndCollaborationAgreementsProceedsAsUpFrontPayment" name="LicenseAndCollaborationAgreementsProceedsAsUpFrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_CovenantsNotToCompeteMember" name="CovenantsNotToCompeteMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DebtTextualAbstract" name="DebtTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareholdersEquityTextualAbstract" name="ShareholdersEquityTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EquityBasedCompensationTextualAbstract" name="EquityBasedCompensationTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FederalMember" name="FederalMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_IncomeTaxesTextualAbstract" name="IncomeTaxesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EmployeeBenefitPlansTextualAbstract" name="EmployeeBenefitPlansTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LeasesTextualAbstract" name="LeasesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DerivativeContractsTextualAbstract" name="DerivativeContractsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ReversalOfAmortizationExpensesDueToErrorCorrection" name="ReversalOfAmortizationExpensesDueToErrorCorrection" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ShareSurrenderInLieuOfCashPayment" name="ShareSurrenderInLieuOfCashPayment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionProFormaEarningsPerShareBasicAndDilutedFromContinuingOperation" name="BusinessAcquisitionProFormaEarningsPerShareBasicAndDilutedFromContinuingOperation" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionProFormaEarningsPerShareBasicAndDilutedFromDiscontinuedOperation" name="BusinessAcquisitionProFormaEarningsPerShareBasicAndDilutedFromDiscontinuedOperation" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" name="BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RepaymentsOfLiabilitiesRelatedToBusinessAcquired" name="RepaymentsOfLiabilitiesRelatedToBusinessAcquired" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_MaturitiesOfShortTermMarketableSecurities" name="MaturitiesOfShortTermMarketableSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ExerciseOfCommonWarrant" name="ExerciseOfCommonWarrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ExerciseOfCommonWarrantsShares" name="ExerciseOfCommonWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AccruedCustomerDeposits" name="AccruedCustomerDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_ItauBankMember" name="ItauBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BankOfChileMember" name="BankOfChileMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BiceBankMember" name="BiceBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SantanderBankMember" name="SantanderBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CorpBancaMember" name="CorpBancaMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BbvaBankMember" name="BbvaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BciMember" name="BciMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SecurityMember" name="SecurityMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfEquityBasedIncentiveCompensationPlans" name="NumberOfEquityBasedIncentiveCompensationPlans" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TwoThousandSevenEquityIncentivePlanMember" name="TwoThousandSevenEquityIncentivePlanMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TwoThousandEquityIncentivePlanMember" name="TwoThousandEquityIncentivePlanMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NineteenNinetySixEquityIncentivePlanMember" name="NineteenNinetySixEquityIncentivePlanMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareBasedCompensationExcessTaxBenefits" name="ShareBasedCompensationExcessTaxBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_RestrictedStockSharesIssuedDuringPeriod" name="RestrictedStockSharesIssuedDuringPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FiniteLivedResearchAndDevelopmentInProcess" name="FiniteLivedResearchAndDevelopmentInProcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingExerciseExpirationDate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingExerciseExpirationDate" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesSurrenderedInLieuOfCashPayments" name="NumberOfSharesSurrenderedInLieuOfCashPayments" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ConvertiblePreferredStockSharesDesignatedMaximum" name="ConvertiblePreferredStockSharesDesignatedMaximum" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfStockHolders" name="NumberOfStockHolders" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PreferredStockConversionPricePerShare" name="PreferredStockConversionPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfConsecutiveTradingDays" name="NumberOfConsecutiveTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EffectiveIncomeTaxRateReconciliationOriginalIssueDiscount" name="EffectiveIncomeTaxRateReconciliationOriginalIssueDiscount" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TaxCreditCarryforwardExpirationPeriod" name="TaxCreditCarryforwardExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SupplementalCashFlowInformationTable" name="SupplementalCashFlowInformationTable" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SupplementalCashFlowInformationLineItems" name="SupplementalCashFlowInformationLineItems" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CommonStockDisclosureAbstract" name="CommonStockDisclosureAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_StockIssuedDuringPeriodSharesToUnderwritersForExerciseOfOverAllotmentOption" name="StockIssuedDuringPeriodSharesToUnderwritersForExerciseOfOverAllotmentOption" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ProceedsFromIssuanceOfCommonStockUnderOverAllotment" name="ProceedsFromIssuanceOfCommonStockUnderOverAllotment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_StockIssuedDuringPeriodSharesNewIssuesIncludingOverAllotment" name="StockIssuedDuringPeriodSharesNewIssuesIncludingOverAllotment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ProceedsFromIssuanceOfCommonStockGross" name="ProceedsFromIssuanceOfCommonStockGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_StockIssuedDuringPeriodSharesSubjectToUnderwriting" name="StockIssuedDuringPeriodSharesSubjectToUnderwriting" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OfferingExpenses" name="OfferingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_StockIssuedDuringPeriodSharesToUnderwritersForOverAllotment" name="StockIssuedDuringPeriodSharesToUnderwritersForOverAllotment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_StockIssuedDuringPeriodSharesWithoutUnderwritingDiscount" name="StockIssuedDuringPeriodSharesWithoutUnderwritingDiscount" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DefinedContributionPlanEmployeeContributionPercentMaximum" name="DefinedContributionPlanEmployeeContributionPercentMaximum" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DefinedContributionPlanEmployeeCompensationPercent" name="DefinedContributionPlanEmployeeCompensationPercent" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DrFrostMember" name="DrFrostMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ForeignExchangeRate" name="ForeignExchangeRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_SelectedQuarterlyFinancialDataTextualAbstract" name="SelectedQuarterlyFinancialDataTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CurnaAcquisitionMember" name="CurnaAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PercentageOfCustomerInRevenue" name="PercentageOfCustomerInRevenue" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OurlabMember" name="OurlabMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesIssuedValue" name="NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesIssuedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_MinimumClosingBidPriceOfCommonStock" name="MinimumClosingBidPriceOfCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShortTermInvestmentsMaturitiesPeriodMinimum" name="ShortTermInvestmentsMaturitiesPeriodMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShortTermInvestmentsMaturitiesPeriodMaximum" name="ShortTermInvestmentsMaturitiesPeriodMaximum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LongTermInvestmentsMaturitiesPeriodMinimum" name="LongTermInvestmentsMaturitiesPeriodMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" name="BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePricePatentsExpensed" name="BusinessAcquisitionPurchasePricePatentsExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_CompositionsOfCertainFinancialStatementCaptionsAbstract" name="CompositionsOfCertainFinancialStatementCaptionsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomesticAndForeignJurisdictionsAbstract" name="IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomesticAndForeignJurisdictionsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareBasedCompensationShareBasedPaymentAwardForNonEmployeesExcisableTerm" name="ShareBasedCompensationShareBasedPaymentAwardForNonEmployeesExcisableTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OwnershipPercentageHeld" name="OwnershipPercentageHeld" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_FairValueMeasurementTextualAbstract" name="FairValueMeasurementTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ExaktaOpkoMember" name="ExaktaOpkoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SummaryOfSignificantAccountingPoliciesAdditionalTextualAbstract" name="SummaryOfSignificantAccountingPoliciesAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ConversionOfStockSharesIssuedAbstract" name="ConversionOfStockSharesIssuedAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_OpkoDiagnosticsAcquisitionMember" name="OpkoDiagnosticsAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AlsMember" name="AlsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" name="BusinessAcquisitionPurchasePriceAllocationProductRegistrations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" name="BusinessAcquisitionPurchasePriceAllocationDeferredPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_FineTechAndOpkoDiagnosticsMember" name="FineTechAndOpkoDiagnosticsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SciGenMember" name="SciGenMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BiozonePharmaceuticalsIncMember" name="BiozonePharmaceuticalsIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ChromaDexMember" name="ChromaDexMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BiozoneMember" name="BiozoneMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FarmadietAcquisitionMember" name="FarmadietAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" name="PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" name="PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" name="PortionOfPaidOnFirstAnniversaryOfClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfPaidInEighteenMonthsAfterClosingDate" name="PortionOfPaidInEighteenMonthsAfterClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscount" name="DeferredAcquisitionPaymentsNetOfDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_DeferredAcquisitionPaymentsDiscount" name="DeferredAcquisitionPaymentsDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_DeferredPaymentToSatisfyIndemnityClaims" name="DeferredPaymentToSatisfyIndemnityClaims" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_NumberOfAncillaryTransaction" name="NumberOfAncillaryTransaction" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AncillaryTransactionDetails" name="AncillaryTransactionDetails" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesIssuedAtClosingDate" name="NumberOfSharesIssuedAtClosingDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesIssuedUponAchievingCertainMilestone" name="NumberOfSharesIssuedUponAchievingCertainMilestone" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" name="PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AmountPayableOnCashOrSharesOnAchievingMilestones" name="AmountPayableOnCashOrSharesOnAchievingMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_ProductInDevelopmentMember" name="ProductInDevelopmentMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" name="BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" name="ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PromissoryNotesMaturityDate" name="PromissoryNotesMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_WarrantsToPurchaseCommonShares" name="WarrantsToPurchaseCommonShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BiozonePharmaceuticalsWarrantsExercised" name="BiozonePharmaceuticalsWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FarmadietContingentConsiderationMember" name="FarmadietContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PentaBankMember" name="PentaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EstadoBankMember" name="EstadoBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SabadellBankMember" name="SabadellBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BilbaoVizcayaBankMember" name="BilbaoVizcayaBankMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BancoPopularMember" name="BancoPopularMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BanestoMember" name="BanestoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BancaMarchMember" name="BancaMarchMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ResearchAgreementMaturityPeriod" name="ResearchAgreementMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FundForResearchAgreement" name="FundForResearchAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_DrLernerMember" name="DrLernerMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AeroPharmaceuticalsIncMember" name="AeroPharmaceuticalsIncMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MrPregoNovoMember" name="MrPregoNovoMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DiagnosticsMember" name="DiagnosticsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscountMember" name="DeferredAcquisitionPaymentsNetOfDiscountMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ContingentConsiderationMember" name="ContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BnzeNoteAndBnzeWarrantsMember" name="BnzeNoteAndBnzeWarrantsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AdditionsToReconciliationOfFairValueMeasurement" name="AdditionsToReconciliationOfFairValueMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_TransferOutToEquityMethodInvestment" name="TransferOutToEquityMethodInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" name="ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CommonStockInvestmentsMember" name="CommonStockInvestmentsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BzneNoteAndBeneficialConversationFeatureMember" name="BzneNoteAndBeneficialConversationFeatureMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TevaPharmaceuticalIndustriesMember" name="TevaPharmaceuticalIndustriesMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LoanToBzne" name="LoanToBzne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionSharePriceOnSharesIssue" name="BusinessAcquisitionSharePriceOnSharesIssue" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_VariableInterestEntityOwnershipAmount" name="VariableInterestEntityOwnershipAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_VariableInterestEntityWorkingCapitalProvidedAmount" name="VariableInterestEntityWorkingCapitalProvidedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_PercentageOfIncreaseDecreaseInDiscountRate" name="PercentageOfIncreaseDecreaseInDiscountRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PercentageOfIncreaseDecreaseInFutureSales" name="PercentageOfIncreaseDecreaseInFutureSales" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_FarmadietMember" name="FarmadietMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OurlabAcquisitionMember" name="OurlabAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OpkoDiagnosticsContingentConsiderationMember" name="OpkoDiagnosticsContingentConsiderationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisedWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisedWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpiredWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpiredWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationLicenses" name="BusinessAcquisitionPurchasePriceAllocationLicenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_InvestmentPropertiesNet" name="InvestmentPropertiesNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" name="DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_NumberOfFinancialInstitutions" name="NumberOfFinancialInstitutions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_InvestmentsLand" name="InvestmentsLand" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_InvestmentsAccumulatedDepreciation" name="InvestmentsAccumulatedDepreciation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_DebtInstrumentMaturityYearStart" name="DebtInstrumentMaturityYearStart" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DebtInstrumentMaturityYearEnd" name="DebtInstrumentMaturityYearEnd" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LossContingencyRecoveryOfCompensatoryDamages" name="LossContingencyRecoveryOfCompensatoryDamages" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_NumberOfSharesReceivedUnderAssetPurchaseAgreement" name="NumberOfSharesReceivedUnderAssetPurchaseAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EstimatedMilestonePaymentToBeReceived" name="EstimatedMilestonePaymentToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_AggregatePurchasePriceOfEquitySecuritiesUnderCytochromaAgreement" name="AggregatePurchasePriceOfEquitySecuritiesUnderCytochromaAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_NumberOfSharesToBeIssuedUnderCytochromaAgreement" name="NumberOfSharesToBeIssuedUnderCytochromaAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NotePurchaseAgreementInitiationDate" name="NotePurchaseAgreementInitiationDate" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AdjustmentOfCommonStockShares" name="AdjustmentOfCommonStockShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AdjustmentOfCommonStockValue" name="AdjustmentOfCommonStockValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
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<element id="opk_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssuedHeldInEscrowAccount" name="BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssuedHeldInEscrowAccount" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionInterestHeldByThirdPartyInAcquireeSubsidiariesPercentage" name="BusinessAcquisitionInterestHeldByThirdPartyInAcquireeSubsidiariesPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfSharesReceivedForProvidingConsultingServices" name="NumberOfSharesReceivedForProvidingConsultingServices" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionSecuredConvertiblePromissoryNotesInterestRateStatedPercentage" name="BusinessAcquisitionSecuredConvertiblePromissoryNotesInterestRateStatedPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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<element id="opk_AdditionalPaymentUponAchievementOfMilestone" name="AdditionalPaymentUponAchievementOfMilestone" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
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<element id="opk_ContingencyLossAndOffsettingIndemnificationAsset" name="ContingencyLossAndOffsettingIndemnificationAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
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<element id="opk_TermOfLease" name="TermOfLease" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PercentageIncreaseInConsumerPriceIndex" name="PercentageIncreaseInConsumerPriceIndex" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
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</schema>

4 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
 7/09/13  SEC                               UPLOAD9/18/17    1:34K  Opko Health, Inc.
 6/11/13  SEC                               UPLOAD9/18/17    1:136K Opko Health, Inc.
 5/09/13  SEC                               UPLOAD9/18/17    1:167K Opko Health, Inc.
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