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Opko Health, Inc. – ‘10-Q’ for 9/30/12 – ‘EX-101.SCH’

On:  Friday, 11/9/12, at 4:31pm ET   ·   For:  9/30/12   ·   Accession #:  1193125-12-463415   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 8/9/12 for 6/30/12   ·   Next:  ‘10-Q’ on 5/10/13 for 3/31/13   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23   ·   1 Reference:  By:  Opko Health, Inc. – ‘10-K’ on 2/18/21 for 12/31/20

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/09/12  Opko Health, Inc.                 10-Q        9/30/12   60:6.7M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    456K 
 2: EX-2.8      Plan of Acquisition, Reorganization, Arrangement,   HTML    287K 
                Liquidation or Succession                                        
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     25K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     25K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     19K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     18K 
40: R1          Document and Entity Information                     HTML     38K 
30: R2          Condensed Consolidated Balance Sheets               HTML    134K 
38: R3          Condensed Consolidated Balance Sheets               HTML     60K 
                (Parenthetical) (Unaudited)                                      
42: R4          Condensed Consolidated Statements of Operations     HTML    116K 
                (Unaudited)                                                      
55: R5          Condensed Consolidated Statements of Comprehensive  HTML     39K 
                Loss (Unaudited)                                                 
32: R6          Condensed Consolidated Statements of Cash Flows     HTML    168K 
                (Unaudited)                                                      
37: R7          Business and Organization                           HTML     29K 
27: R8          Summary of Significant Accounting Policies          HTML     41K 
18: R9          Loss Per Share                                      HTML     24K 
56: R10         Composition of Certain Financial Statement          HTML     55K 
                Captions                                                         
44: R11         Acquisitions, Investments, and Licenses             HTML     98K 
43: R12         Discontinued Operations                             HTML     44K 
48: R13         Fair Value Measurements                             HTML     86K 
49: R14         Derivative Contracts                                HTML     43K 
47: R15         Related Party Transactions                          HTML     40K 
50: R16         Commitments and Contingencies                       HTML     26K 
39: R17         Segments                                            HTML     61K 
41: R18         Subsequent Events                                   HTML     23K 
46: R19         Summary of Significant Accounting Policies          HTML    100K 
                (Policies)                                                       
60: R20         Composition of Certain Financial Statement          HTML     54K 
                Captions (Tables)                                                
52: R21         Acquisitions, Investments, and Licenses (Tables)    HTML     75K 
34: R22         Discontinued Operations (Tables)                    HTML     39K 
45: R23         Fair Value Measurements (Tables)                    HTML     85K 
36: R24         Derivative Contracts (Tables)                       HTML     32K 
15: R25         Segments (Tables)                                   HTML     52K 
53: R26         Summary of Significant Accounting Policies          HTML     40K 
                (Details)                                                        
57: R27         Loss Per Share (Details)                            HTML     28K 
23: R28         Composition of Certain Financial Statement          HTML    115K 
                Captions (Details)                                               
22: R29         Acquisitions, Investments, and Licenses (Details)   HTML     70K 
25: R30         Acquisitions, Investments, and Licenses (Details    HTML     49K 
                1)                                                               
26: R31         Acquisitions, Investments, and Licenses (Details    HTML     64K 
                2)                                                               
28: R32         Acquisitions, Investments, and Licenses (Details    HTML    286K 
                Textual)                                                         
14: R33         Discontinued Operations (Details)                   HTML     34K 
51: R34         Discontinued Operations (Details 1)                 HTML     34K 
33: R35         Discontinued Operations (Details Textual)           HTML     23K 
35: R36         Fair Value Measurements (Details)                   HTML     41K 
17: R37         Fair Value Measurements (Details 1)                 HTML     73K 
59: R38         Fair Value Measurements (Details 2)                 HTML     41K 
13: R39         Fair Value Measurements (Details Textual)           HTML     38K 
29: R40         Derivative Contracts (Details)                      HTML     33K 
54: R41         Related Party Transactions (Details)                HTML    239K 
16: R42         Commitments and Contingencies (Details)             HTML     33K 
21: R43         Segments (Details)                                  HTML     42K 
24: R44         Segments (Details Textual)                          HTML     30K 
31: R45         Subsequent Events (Details)                         HTML     34K 
58: XML         IDEA XML File -- Filing Summary                      XML     88K 
20: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.03M 
 7: EX-101.INS  XBRL Instance -- opk-20120930                        XML   1.31M 
 9: EX-101.CAL  XBRL Calculations -- opk-20120930_cal                XML    186K 
10: EX-101.DEF  XBRL Definitions -- opk-20120930_def                 XML    592K 
11: EX-101.LAB  XBRL Labels -- opk-20120930_lab                      XML   1.25M 
12: EX-101.PRE  XBRL Presentations -- opk-20120930_pre               XML    848K 
 8: EX-101.SCH  XBRL Schema -- opk-20120930                          XSD    187K 
19: ZIP         XBRL Zipped Folder -- 0001193125-12-463415-xbrl      Zip    146K

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<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<import namespace="http://fasb.org/us-gaap/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/exch/2012-01-31" schemaLocation="http://xbrl.sec.gov/exch/2012/exch-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/country/2012-01-31" schemaLocation="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd"/>
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<import namespace="http://xbrl.sec.gov/currency/2012-01-31" schemaLocation="http://xbrl.sec.gov/currency/2012/currency-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<element name="DocumentAndEntityInformationAbstract" id="opk_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element id="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" name="GainLossFromContinuingOperationsBeforeInvestmentLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_WeightedAverageNumberOfCommonShareOutstandingBasicAndDiluted" name="WeightedAverageNumberOfCommonShareOutstandingBasicAndDiluted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ProvisionRecoveryOfForDoubtfulAccounts" name="ProvisionRecoveryOfForDoubtfulAccounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ProvisionForReversalOfInventoryReserves" name="ProvisionForReversalOfInventoryReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_MaturitiesOfShortTermMarketableSecurities" name="MaturitiesOfShortTermMarketableSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_SummaryOfSignificantAccountingPoliciesTextualAbstract" name="SummaryOfSignificantAccountingPoliciesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LossPerShareTextualAbstract" name="LossPerShareTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationTechnology" name="BusinessAcquisitionPurchasePriceAllocationTechnology" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_SorrentoMember" name="SorrentoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CocrystalMember" name="CocrystalMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FabrusMember" name="FabrusMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TesaroMember" name="TesaroMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NeovascMember" name="NeovascMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DisposalGroupIncludingDiscontinuedOperationReceivedRoyalties" name="DisposalGroupIncludingDiscontinuedOperationReceivedRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_FairValueMeasurementsTextualAbstract" name="FairValueMeasurementsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ZeroToThirtyMember" name="ZeroToThirtyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ThirtyOneToSixtyMember" name="ThirtyOneToSixtyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SixtyOneToNinetyMember" name="SixtyOneToNinetyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NinetyOneToOneHundredTwentyMember" name="NinetyOneToOneHundredTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OneHundredTwentyOneToOneHundredEightyMember" name="OneHundredTwentyOneToOneHundredEightyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MoreThanOneHundredEightyMember" name="MoreThanOneHundredEightyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_GammaTrustMember" name="GammaTrustMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_HsuGammaMember" name="HsuGammaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TimeOfTransactionPercentageOwned" name="TimeOfTransactionPercentageOwned" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_GrossRentIsForTwoYearTerm" name="GrossRentIsForTwoYearTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_LicensingFeesPreviouslyPaid" name="LicensingFeesPreviouslyPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_LicensingFeesPaid" name="LicensingFeesPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_ReimbursementOfCertainExpenses" name="ReimbursementOfCertainExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AgreementPursuantToWhichInvested" name="AgreementPursuantToWhichInvested" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AgreementToLeaseSpaceToHouseManufacturing" name="AgreementToLeaseSpaceToHouseManufacturing" type="num:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_GrossRentPayableUnderLease" name="GrossRentPayableUnderLease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_AcquisitionAndInvestmentsTextualAbstract" name="AcquisitionAndInvestmentsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CommitmentsAndContingenciesTextualAbstract" name="CommitmentsAndContingenciesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SegmentsTextualAbstract" name="SegmentsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AllowanceForDoubtfulAccountsPolicyTextBlock" name="AllowanceForDoubtfulAccountsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfCommonSharesToBeIssuedOnConversionOfPreferredStock" name="NumberOfCommonSharesToBeIssuedOnConversionOfPreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_CompositionOfCertainFinancialStatementCaptionsTableTextBlock" name="CompositionOfCertainFinancialStatementCaptionsTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract" name="BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" name="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_VariableInterestEntityEntityAccountingMethod" name="VariableInterestEntityEntityAccountingMethod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_VariableInterestEntityEntityAccumulatedLossesInInvestees" name="VariableInterestEntityEntityAccumulatedLossesInInvestees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_VariableInterestEntityEntityMaximumNetLossExposureAmount" name="VariableInterestEntityEntityMaximumNetLossExposureAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_DisposalGroupIncludingDiscontinuedOperationClassifiedBalanceSheetDisclosuresTableTextBlock" name="DisposalGroupIncludingDiscontinuedOperationClassifiedBalanceSheetDisclosuresTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities" name="DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_DisposalGroupNotDiscontinuedOperationIncomeStatementDisclosuresTableTextBlock" name="DisposalGroupNotDiscontinuedOperationIncomeStatementDisclosuresTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DiscontinuedOperationsTextualAbstract" name="DiscontinuedOperationsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract" name="FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MaturityDateOfSecurity" name="MaturityDateOfSecurity" type="xbrli:dateItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing" name="BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" name="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" name="NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" name="ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FairValueOfWarrantsAcquiredInEquityMethodInvestment" name="FairValueOfWarrantsAcquiredInEquityMethodInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_FinancingForVariableInterestEntities" name="FinancingForVariableInterestEntities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_EquityInvestment" name="EquityInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup" name="OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_OwnershipPercentageOfVariablesInterestEntity" name="OwnershipPercentageOfVariablesInterestEntity" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NeovascIncMember" name="NeovascIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CocrystalDiscoveryIncMember" name="CocrystalDiscoveryIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_SorrentoTherapeuticsIncMember" name="SorrentoTherapeuticsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementOneMember" name="ManagementOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OwnershipPercentageHeldByMembers" name="OwnershipPercentageHeldByMembers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_MaximumOwnershipPercentageHeldByMembers" name="MaximumOwnershipPercentageHeldByMembers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_ManagementTwoMember" name="ManagementTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementFourMember" name="ManagementFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OwnershipPercentageHeldByDirector" name="OwnershipPercentageHeldByDirector" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AreaForMolecularDiagnosticsOperations" name="AreaForMolecularDiagnosticsOperations" type="num:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_ResearchAndDevelopmentAgreementAmountForPeriod" name="ResearchAndDevelopmentAgreementAmountForPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_TrsiMember" name="TrsiMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PreviousInvestmentByGroupOfInvestor" name="PreviousInvestmentByGroupOfInvestor" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_AdditionalInvestmentByGroupOfInvestor" name="AdditionalInvestmentByGroupOfInvestor" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_AdditionalAgreementToLeaseSpaceToHouseManufacturing" name="AdditionalAgreementToLeaseSpaceToHouseManufacturing" type="num:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_RealEstateHoldingsLlcMember" name="RealEstateHoldingsLlcMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" name="LeaseSpaceInOfficeBuildingHavingPrincipalOffice" type="num:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_LeaseRentPerMonthForFirstYear" name="LeaseRentPerMonthForFirstYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_CreditForTenantImprovements" name="CreditForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ReimbursementPaidToRelatedPartyForTravel" name="ReimbursementPaidToRelatedPartyForTravel" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_LeaseRentPerMonthForFifthYear" name="LeaseRentPerMonthForFifthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" name="ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AccountsReceivableFromMajorCustomer" name="AccountsReceivableFromMajorCustomer" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_CustomerOneMember" name="CustomerOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" name="MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MinimumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsMarketableSecurities" name="MinimumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsMarketableSecurities" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FabrusLlcMember" name="FabrusLlcMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfYearsOverWhichRevenueWillBeRecognized" name="NumberOfYearsOverWhichRevenueWillBeRecognized" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" name="MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CompositionOfCertainFinancialStatementCaptionsAbstract" name="CompositionOfCertainFinancialStatementCaptionsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PercentageInBoardOfManagers" name="PercentageInBoardOfManagers" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AcquisitionAndInvestmentsAdditionalTextualAbstract" name="AcquisitionAndInvestmentsAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_InvestmentInVariableInterestEntities" name="InvestmentInVariableInterestEntities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_NumberOfLicenseAgreements" name="NumberOfLicenseAgreements" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_RelatedPartyTransactionsTextualAbstract" name="RelatedPartyTransactionsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RelatedPartyTransactionsAdditionalTextualAbstract" name="RelatedPartyTransactionsAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfReportableSegment" name="NumberOfReportableSegment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfOperatingSegment" name="NumberOfOperatingSegment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_GammaTrustAndHsuGammaMember" name="GammaTrustAndHsuGammaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" name="NumberOfConvertibleSeriesPreferredStockHeldFromAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_DrRichardLernerMember" name="DrRichardLernerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" name="TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" name="AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_OutstandingCommonSharesAcquired" name="OutstandingCommonSharesAcquired" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfEqualInstallmentsPayableForAdditionalInvestment" name="NumberOfEqualInstallmentsPayableForAdditionalInvestment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_FirstInstallmentInvestment" name="FirstInstallmentInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_RevenueFromReceiptOfEquity" name="RevenueFromReceiptOfEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_ForeignCurrencyMeasurement" name="ForeignCurrencyMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_FinetechAcquisitionMember" name="FinetechAcquisitionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ContingentConsiderationLongTermObligations" name="ContingentConsiderationLongTermObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_FiniteLivedResearchAndDevelopmentInProcess" name="FiniteLivedResearchAndDevelopmentInProcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" name="BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationTradeName" name="BusinessAcquisitionPurchasePriceAllocationTradeName" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ClarosDiagnosticsMember" name="ClarosDiagnosticsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ChromaDexMember" name="ChromaDexMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BiozoneMember" name="BiozoneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EquityInvestmentYear" name="EquityInvestmentYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" name="BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_BzneNoteAndBeneficialConversationFeatureMember" name="BzneNoteAndBeneficialConversationFeatureMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FinetechContingentConsiderationMember" name="FinetechContingentConsiderationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AverageClosingSalesPricePerShareOfCommonStock" name="AverageClosingSalesPricePerShareOfCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ChromadexCorporationMember" name="ChromadexCorporationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_WorkingCapitalSurplus" name="WorkingCapitalSurplus" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_FabrusAndDrsFrostMember" name="FabrusAndDrsFrostMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_HsiaoAndLernerMember" name="HsiaoAndLernerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ValueOfStockConsiderationHeldInEscrowAccount" name="ValueOfStockConsiderationHeldInEscrowAccount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchaseOfCommonStockShares" name="BusinessAcquisitionPurchaseOfCommonStockShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_BiozonePharmaceuticalsIncMember" name="BiozonePharmaceuticalsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_PromissoryNotesMaturityDate" name="PromissoryNotesMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_WarrantsDuration" name="WarrantsDuration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_WarrantsToPurchaseCommonShares" name="WarrantsToPurchaseCommonShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_UnrealizedGainOnWarrants" name="UnrealizedGainOnWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchaseOfSeriesPreferredStock" name="BusinessAcquisitionPurchaseOfSeriesPreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TevaPharmaceuticalIndustriesLtdMember" name="TevaPharmaceuticalIndustriesLtdMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BnzeNoteAndBnzeWarrantsMember" name="BnzeNoteAndBnzeWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AdditionsToReconciliationOfFairValueMeasurement" name="AdditionsToReconciliationOfFairValueMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_ContingentConsiderationMember" name="ContingentConsiderationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementFiveMember" name="ManagementFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementSixMember" name="ManagementSixMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementSevenMember" name="ManagementSevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ManagementEightMember" name="ManagementEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AeroPharmaceuticalsIncMember" name="AeroPharmaceuticalsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DiscontinuedOperationsMember" name="DiscontinuedOperationsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" name="EffectOfLossOnForeignCurrencyDerivativeBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_RelatedPartyTransactionAxis" name="RelatedPartyTransactionAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RelatedPartyTransactionDomain" name="RelatedPartyTransactionDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_MrPregoNovoMember" name="MrPregoNovoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" name="ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ClaimAgainstEscrowForUndisclosedLiabilities" name="ClaimAgainstEscrowForUndisclosedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_OwnershipPercentageHeld" name="OwnershipPercentageHeld" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_LoanToBzne" name="LoanToBzne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_CommonStockIssuedForStockOptionAndWarrantsExercises" name="CommonStockIssuedForStockOptionAndWarrantsExercises" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NeovascOptionsMember" name="NeovascOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" name="BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_AlsAcquisitionMember" name="AlsAcquisitionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CommonStockInvestmentsMember" name="CommonStockInvestmentsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_OpkoContigentConsiderationMember" name="OpkoContigentConsiderationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TevaPharmaceuticalIndustriesMember" name="TevaPharmaceuticalIndustriesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FabrusIncMember" name="FabrusIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_NumberOfCustomerRepresentation" name="NumberOfCustomerRepresentation" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RelatedPartyAffliatesAxis" name="RelatedPartyAffliatesAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration"/>
<element id="opk_RelatedPartyAffliatesDomain" name="RelatedPartyAffliatesDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_UnrealizedGainOnInvestmentsOptionsAndWarrants" name="UnrealizedGainOnInvestmentsOptionsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_AramaLaboratoriesAcquisitionMember" name="AramaLaboratoriesAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_ProductInDevelopmentMember" name="ProductInDevelopmentMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_FarmadietAcquisitionMember" name="FarmadietAcquisitionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_DeferredPaymentToSatisfyIndemnityClaims" name="DeferredPaymentToSatisfyIndemnityClaims" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_NumberOfTradingDays" name="NumberOfTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfAncillaryTransaction" name="NumberOfAncillaryTransaction" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AncillaryTransactionDetails" name="AncillaryTransactionDetails" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesIssuedAtClosingDate" name="NumberOfSharesIssuedAtClosingDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_NumberOfSharesIssuedUponAchievingCertainMilestone" name="NumberOfSharesIssuedUponAchievingCertainMilestone" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_AmountPayableOnCashOrSharesOnAchievingMilestones" name="AmountPayableOnCashOrSharesOnAchievingMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BiozonePharmaceuticalsWarrantsExercised" name="BiozonePharmaceuticalsWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PercentageOfCustomerInTotalRevenue" name="PercentageOfCustomerInTotalRevenue" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_CurnaAcquisitionMember" name="CurnaAcquisitionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_AccruedClinicalTrials" name="AccruedClinicalTrials" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_IssuanceOfCommonStockToAcquireEntity" name="IssuanceOfCommonStockToAcquireEntity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_CommonStockWarrantsNetExercised" name="CommonStockWarrantsNetExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_FarmadietContingentConsiderationMember" name="FarmadietContingentConsiderationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" name="BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" name="BusinessAcquisitionPurchasePriceAllocationProductRegistrations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" name="BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" name="BusinessAcquisitionPurchasePriceAllocationDeferredPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_AdditionalAmountPaidForLegalRegistration" name="AdditionalAmountPaidForLegalRegistration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_FairValueOfContingentConsiderationPeriodIncrease" name="FairValueOfContingentConsiderationPeriodIncrease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscount" name="DeferredAcquisitionPaymentsNetOfDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" name="DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
<element id="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" name="PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" name="PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" name="PortionOfPaidOnFirstAnniversaryOfClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfPaidInEighteenMonthsAfterClosingDate" name="PortionOfPaidInEighteenMonthsAfterClosingDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" name="PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant"/>
<element id="opk_DeferredAcquisitionPaymentsDiscount" name="DeferredAcquisitionPaymentsDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_DeferredAcquisitionPaymentsNetOfDiscountMember" name="DeferredAcquisitionPaymentsNetOfDiscountMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<element id="opk_TransferOutToEquityMethodInvestment" name="TransferOutToEquityMethodInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
<element id="opk_FundForResearchAgreement" name="FundForResearchAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit"/>
<element id="opk_ResearchAgreementMaturityPeriod" name="ResearchAgreementMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
</schema>

1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
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