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Ziopharm Oncology Inc – ‘10-Q’ for 9/30/14 – ‘EX-101.SCH’

On:  Thursday, 10/30/14, at 4:01pm ET   ·   For:  9/30/14   ·   Accession #:  1193125-14-389572   ·   File #:  1-33038

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

10/30/14  Ziopharm Oncology Inc             10-Q        9/30/14   51:4.2M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    475K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     19K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     19K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     17K 
33: R1          Document and Entity Information                     HTML     38K 
24: R2          Balance Sheets                                      HTML    102K 
31: R3          Balance Sheets (Parenthetical)                      HTML     36K 
35: R4          Statements of Operations                            HTML     45K 
47: R5          Statement of Stockholders' Equity                   HTML     55K 
25: R6          Statements of Cash Flows                            HTML    104K 
30: R7          Business                                            HTML     28K 
22: R8          Summary of Significant Accounting Policies          HTML     19K 
16: R9          Recently Issued Accounting Pronouncements           HTML     18K 
48: R10         Restructuring                                       HTML     24K 
37: R11         Fair Value Measurements                             HTML     34K 
36: R12         Net Loss per Share                                  HTML     23K 
41: R13         Related Party Transactions                          HTML     23K 
42: R14         Commitments and Contingencies                       HTML     72K 
40: R15         Warrants                                            HTML     47K 
43: R16         Common Stock                                        HTML     19K 
32: R17         Stock-Based Compensation                            HTML     55K 
34: R18         Fair Value Measurements (Tables)                    HTML     30K 
39: R19         Net Loss per Share (Tables)                         HTML     22K 
51: R20         Warrants (Tables)                                   HTML     48K 
45: R21         Stock-Based Compensation (Tables)                   HTML     56K 
27: R22         Business - Additional Information (Detail)          HTML     19K 
38: R23         Restructuring - Additional Information (Detail)     HTML     40K 
29: R24         Assets and Liabilities Measured at Fair Value on    HTML     23K 
                Recurring Basis (Detail)                                         
14: R25         Potential Dilutive Shares Excluded from             HTML     23K 
                Computation of Diluted Net Loss Per Share (Detail)               
46: R26         Related Party Transactions - Additional             HTML     33K 
                Information (Detail)                                             
49: R27         Commitments and Contingencies - Additional          HTML    233K 
                Information (Detail)                                             
19: R28         Number of Warrants Outstanding (Detail)             HTML     20K 
18: R29         Warrants - Additional Information (Detail)          HTML     51K 
20: R30         Assumptions Used In Binomial Valuation Model and    HTML     28K 
                Black-Scholes Valuation Model (Detail)                           
21: R31         Warrant Exercise (Detail)                           HTML     26K 
23: R32         Common Stock - Additional Information (Detail)      HTML     29K 
12: R33         Stock-Based Compensation Expense on All Employee    HTML     22K 
                and Non-Employee Awards (Detail)                                 
44: R34         Stock-Based Compensation - Additional Information   HTML     45K 
                (Detail)                                                         
26: R35         Fair Value of Stock Options Assumptions Using       HTML     37K 
                Black-Scholes Option Valuation Model (Detail)                    
28: R36         Stock Option Activity Under Stock Option Plan       HTML     76K 
                (Detail)                                                         
15: R37         Summary of Unvested Restricted Stock (Detail)       HTML     40K 
50: XML         IDEA XML File -- Filing Summary                      XML     75K 
11: EXCEL       IDEA Workbook of Financial Reports                  XLSX    117K 
17: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS    527K 
 5: EX-101.INS  XBRL Instance -- ziop-20140930                       XML    796K 
 7: EX-101.CAL  XBRL Calculations -- ziop-20140930_cal               XML    109K 
 8: EX-101.DEF  XBRL Definitions -- ziop-20140930_def                XML    668K 
 9: EX-101.LAB  XBRL Labels -- ziop-20140930_lab                     XML    945K 
10: EX-101.PRE  XBRL Presentations -- ziop-20140930_pre              XML    741K 
 6: EX-101.SCH  XBRL Schema -- ziop-20140930                         XSD    132K 
13: ZIP         XBRL Zipped Folder -- 0001193125-14-389572-xbrl      Zip    107K

‘EX-101.SCH’   —   XBRL Schema — ziop-20140930

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:definition> 106 - Statement - STATEMENT OF STOCKHOLDERS' EQUITY </link:definition>
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<link:definition> 107 - Statement - STATEMENTS OF CASH FLOWS </link:definition>
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<link:definition> 108 - Disclosure - Business </link:definition>
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<link:definition> 109 - Disclosure - Summary of Significant Accounting Policies </link:definition>
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<link:definition> 110 - Disclosure - Recently Issued Accounting Pronouncements </link:definition>
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<link:definition> 111 - Disclosure - Restructuring </link:definition>
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<link:definition> 112 - Disclosure - Fair Value Measurements </link:definition>
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<link:definition> 113 - Disclosure - Net Loss per Share </link:definition>
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<link:definition> 114 - Disclosure - Related Party Transactions </link:definition>
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<link:definition> 115 - Disclosure - Commitments and Contingencies </link:definition>
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<link:definition> 116 - Disclosure - Warrants </link:definition>
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<link:definition> 117 - Disclosure - Common Stock </link:definition>
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<link:definition> 118 - Disclosure - Stock-Based Compensation </link:definition>
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<link:definition> 119 - Disclosure - Fair Value Measurements (Tables) </link:definition>
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<link:definition> 120 - Disclosure - Net Loss per Share (Tables) </link:definition>
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<link:definition> 121 - Disclosure - Warrants (Tables) </link:definition>
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<link:definition> 122 - Disclosure - Stock-Based Compensation (Tables) </link:definition>
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<link:definition> 123 - Disclosure - Business - Additional Information (Detail) </link:definition>
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<link:definition> 124 - Disclosure - Restructuring - Additional Information (Detail) </link:definition>
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<link:definition> 125 - Disclosure - Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) </link:definition>
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<link:definition> 126 - Disclosure - Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail) </link:definition>
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<link:definition> 127 - Disclosure - Related Party Transactions - Additional Information (Detail) </link:definition>
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<link:definition> 128 - Disclosure - Commitments and Contingencies - Additional Information (Detail) </link:definition>
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<link:definition> 129 - Disclosure - Number of Warrants Outstanding (Detail) </link:definition>
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<link:definition> 130 - Disclosure - Warrants - Additional Information (Detail) </link:definition>
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<link:definition> 131 - Disclosure - Assumptions Used In Binomial Valuation Model and Black-Scholes Valuation Model (Detail) </link:definition>
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<link:definition> 134 - Disclosure - Stock-Based Compensation Expense on All Employee and Non-Employee Awards (Detail) </link:definition>
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<link:definition> 136 - Disclosure - Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model (Detail) </link:definition>
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<link:definition> 137 - Disclosure - Stock Option Activity Under Stock Option Plan (Detail) </link:definition>
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<link:definition> 138 - Disclosure - Summary of Unvested Restricted Stock (Detail) </link:definition>
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<import namespace="http://xbrl.sec.gov/country/2013-01-31" schemaLocation="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/currency/2014-01-31" schemaLocation="http://xbrl.sec.gov/currency/2014/currency-2014-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/exch/2014-01-31" schemaLocation="http://xbrl.sec.gov/exch/2014/exch-2014-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<element name="AdditionalPaidInCapitalCommonStockMember" id="ziop_AdditionalPaidInCapitalCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AdjustmentsToAdditionalPaidInCapitalWarrantExpired" id="ziop_AdjustmentsToAdditionalPaidInCapitalWarrantExpired" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterAmendmentMember" id="ziop_AfterAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterExtensionMember" id="ziop_AfterExtensionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AggregateDecreaseToCostsAndExpenses" id="ziop_AggregateDecreaseToCostsAndExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AmendmentAxis" id="ziop_AmendmentAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="AmendmentDomain" id="ziop_AmendmentDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AssetAcquiredOtherThanThroughBusinessCombinationAdditionalCashPaidForExistingInventory" id="ziop_AssetAcquiredOtherThanThroughBusinessCombinationAdditionalCashPaidForExistingInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AssetAcquiredOtherThanThroughBusinessCombinationCashPaid" id="ziop_AssetAcquiredOtherThanThroughBusinessCombinationCashPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BaxterHealthcareCorporationMember" id="ziop_BaxterHealthcareCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeforeExtensionMember" id="ziop_BeforeExtensionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BlackScholesOptionPricingModelMember" id="ziop_BlackScholesOptionPricingModelMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CaseOneMember" id="ziop_CaseOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CaseTwoMember" id="ziop_CaseTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CashlessExerciseMember" id="ziop_CashlessExerciseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExercisedInPeriod" id="ziop_ClassOfWarrantOrRightExercisedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExercisePeriod" id="ziop_ClassOfWarrantOrRightExercisePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightFairValueAssumptionStepsPerYear" id="ziop_ClassOfWarrantOrRightFairValueAssumptionStepsPerYear" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantTerm" id="ziop_ClassOfWarrantTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborationAgreementMember" id="ziop_CollaborationAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborativeArrangementAdditionalUpFrontPaymentToBeReceived" id="ziop_CollaborativeArrangementAdditionalUpFrontPaymentToBeReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentAndContingenciesAxis" id="ziop_CommitmentAndContingenciesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="CommitmentAndContingenciesDomain" id="ziop_CommitmentAndContingenciesDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureLineItems" id="ziop_CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureTable" id="ziop_CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="CommonStockDisclosureTextBlock" id="ziop_CommonStockDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContractTerminationDescription" id="ziop_ContractTerminationDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DEKKTecIncMember" id="ziop_DEKKTecIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DevelopmentMilestonePaymentsMember" id="ziop_DevelopmentMilestonePaymentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DocumentAndEntityInformationAbstract" id="ziop_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EmployeeTwoMember" id="ziop_EmployeeTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EstimatedFairValueOfWarrant" id="ziop_EstimatedFairValueOfWarrant" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExecutionOfSubscriptionAgreementMember" id="ziop_ExecutionOfSubscriptionAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupElevenMember" id="ziop_GroupElevenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupFiveMember" id="ziop_GroupFiveMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupFourMember" id="ziop_GroupFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupOneMember" id="ziop_GroupOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupTenMember" id="ziop_GroupTenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupThreeMember" id="ziop_GroupThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupTwoMember" id="ziop_GroupTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="HarmonHillLlcMember" id="ziop_HarmonHillLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IntellectualPropertyRightsMember" id="ziop_IntellectualPropertyRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IntrexonCorporationMember" id="ziop_IntrexonCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="InvestmentOptionExercisePeriod" id="ziop_InvestmentOptionExercisePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="JpMorganSecuritiesIncMember" id="ziop_JpMorganSecuritiesIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LeaseFourMember" id="ziop_LeaseFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LeaseOneMember" id="ziop_LeaseOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LeaseThreeMember" id="ziop_LeaseThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LeaseTwoMember" id="ziop_LeaseTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LiabilitiesMember" id="ziop_LiabilitiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LossOnSublease" id="ziop_LossOnSublease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="ziop_MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentsMaximumAmount" id="ziop_MilestonePaymentsMaximumAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MonthlyPaymentMember" id="ziop_MonthlyPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NatureOfBusinessTable" id="ziop_NatureOfBusinessTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="NatureOfOperationsLineItems" id="ziop_NatureOfOperationsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NetProceedsFromIssuanceOfCommonStock" id="ziop_NetProceedsFromIssuanceOfCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonvestedOptionMember" id="ziop_NonvestedOptionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonVestedRestrictedStockMember" id="ziop_NonVestedRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NovellaClinicalIncMember" id="ziop_NovellaClinicalIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfProducts" id="ziop_NumberOfProducts" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OfficeSpaceUnderLease" id="ziop_OfficeSpaceUnderLease" type="num:areaItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLeaseAdditionalOfficeSpace" id="ziop_OperatingLeaseAdditionalOfficeSpace" type="num:areaItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLeasesExpirationMonthAndYear" id="ziop_OperatingLeasesExpirationMonthAndYear" type="xbrli:gYearMonthItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLeaseSpace" id="ziop_OperatingLeaseSpace" type="num:areaItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OptionsToPurchaseCommonStock" id="ziop_OptionsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OptionsVestedMember" id="ziop_OptionsVestedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfNetProfit" id="ziop_PercentageOfNetProfit" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfRevenue" id="ziop_PercentageOfRevenue" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PeriodTypeAxis" id="ziop_PeriodTypeAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="PeriodTypeDomain" id="ziop_PeriodTypeDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PharmaceuticalResearchAssociatesIncMember" id="ziop_PharmaceuticalResearchAssociatesIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseOneMember" id="ziop_PhaseOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseThreeMember" id="ziop_PhaseThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseTwoMember" id="ziop_PhaseTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PPDDevelopmentLPMember" id="ziop_PPDDevelopmentLPMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PublicOfferingMember" id="ziop_PublicOfferingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PublicOfferingNetPricePerShare" id="ziop_PublicOfferingNetPricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="QuarterlyPaymentMember" id="ziop_QuarterlyPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RequirementOfEligibleFutureMilestonePaymentsAxis" id="ziop_RequirementOfEligibleFutureMilestonePaymentsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="RequirementOfEligibleFutureMilestonePaymentsDomain" id="ziop_RequirementOfEligibleFutureMilestonePaymentsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RestructuringActivitiesEliminationOfEmployeesAxis" id="ziop_RestructuringActivitiesEliminationOfEmployeesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="RestructuringActivitiesEliminationOfEmployeesDomain" id="ziop_RestructuringActivitiesEliminationOfEmployeesDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RevenueRecognitionPeriod" id="ziop_RevenueRecognitionPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SalesEventsMilestoneMember" id="ziop_SalesEventsMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfSecuritiesValuationAssumptionsTableTextBlock" id="ziop_ScheduleOfSecuritiesValuationAssumptionsTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfStockholdersEquityNoteWarrantsAndCommonStockActivityTableTextBlock" id="ziop_ScheduleOfStockholdersEquityNoteWarrantsAndCommonStockActivityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpectedToVestNumber" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpectedToVestNumber" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SolasiaPharmaKKMember" id="ziop_SolasiaPharmaKKMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SouthernResearchInstituteMember" id="ziop_SouthernResearchInstituteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesStockWarrantsExercised" id="ziop_StockIssuedDuringPeriodSharesStockWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueStockWarrantsExercised" id="ziop_StockIssuedDuringPeriodValueStockWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedMember" id="ziop_StockIssuedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockWarrantsTextBlock" id="ziop_StockWarrantsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SubleasedAgreementArea" id="ziop_SubleasedAgreementArea" type="num:areaItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" id="ziop_TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UncategorizedAbstract" id="ziop_UncategorizedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UnderwriterMember" id="ziop_UnderwriterMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UpFrontPaymentMember" id="ziop_UpFrontPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantCashExerciseMember" id="ziop_WarrantCashExerciseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantLiabilitiesFairValueDisclosure" id="ziop_WarrantLiabilitiesFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsClassifiedAsEquityMember" id="ziop_WarrantsClassifiedAsEquityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsIssuedInInitialPublicOffering" id="ziop_WarrantsIssuedInInitialPublicOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsLiability" id="ziop_WarrantsLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsToPurchaseAggregateSharesOfCommonStock" id="ziop_WarrantsToPurchaseAggregateSharesOfCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>

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