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Ziopharm Oncology Inc – ‘10-Q’ for 6/30/17 – ‘EX-101.SCH’

On:  Monday, 7/31/17, at 4:02pm ET   ·   For:  6/30/17   ·   Accession #:  1193125-17-242331   ·   File #:  1-33038

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 7/31/17  Ziopharm Oncology Inc             10-Q        6/30/17   53:3.8M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    615K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     20K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     20K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     18K 
11: R1          Document and Entity Information                     HTML     38K 
12: R2          Balance Sheets                                      HTML     98K 
13: R3          Balance Sheets (Parenthetical)                      HTML     47K 
14: R4          Statements of Operations                            HTML     48K 
15: R5          Statements of Stockholders' Deficit                 HTML     60K 
16: R6          Statements of Stockholders' Deficit                 HTML     18K 
                (Parenthetical)                                                  
17: R7          Statements of Cash Flows                            HTML     97K 
18: R8          Statements of Cash Flows (Parenthetical)            HTML     18K 
19: R9          Business                                            HTML     30K 
20: R10         Financings                                          HTML     20K 
21: R11         Summary of Significant Accounting Policies          HTML     27K 
22: R12         Fair Value Measurements                             HTML     45K 
23: R13         Net Loss per Share                                  HTML     28K 
24: R14         Commitments and Contingencies                       HTML    104K 
25: R15         Related Party Transactions                          HTML     36K 
26: R16         Stock-Based Compensation                            HTML     56K 
27: R17         Preferred Stock                                     HTML     34K 
28: R18         Derivative Financial Instruments                    HTML     35K 
29: R19         Summary of Significant Accounting Policies          HTML     27K 
                (Policies)                                                       
30: R20         Fair Value Measurements (Tables)                    HTML     36K 
31: R21         Net Loss per Share (Tables)                         HTML     25K 
32: R22         Stock-Based Compensation (Tables)                   HTML     58K 
33: R23         Derivative Financial Instruments (Tables)           HTML     36K 
34: R24         Business - Additional Information (Detail)          HTML     21K 
35: R25         Financings - Additional Information (Detail)        HTML     25K 
36: R26         Assets and Liabilities Measured at Fair Value on    HTML     31K 
                Recurring Basis (Detail)                                         
37: R27         Fair Value Measurements - Additional Information    HTML     22K 
                (Detail)                                                         
38: R28         Potential Dilutive Shares Excluded from             HTML     28K 
                Computation of Diluted Net Loss Per Share (Detail)               
39: R29         Net Loss per Share - Additional Information         HTML     26K 
                (Detail)                                                         
40: R30         Commitments and Contingencies - Additional          HTML    303K 
                Information (Detail)                                             
41: R31         Related Party Transactions - Additional             HTML    115K 
                Information (Detail)                                             
42: R32         Stock-Based Compensation Expense Included in        HTML     25K 
                Statement of Operations (Detail)                                 
43: R33         Stock-Based Compensation - Additional Information   HTML     40K 
                (Detail)                                                         
44: R34         Fair Value of Stock Options Assumptions Using       HTML     32K 
                Black-Scholes Option Valuation Model (Detail)                    
45: R35         Stock Option Activity Under Stock Option Plan       HTML     62K 
                (Detail)                                                         
46: R36         Summary of Unvested Restricted Stock (Detail)       HTML     42K 
47: R37         Preferred Stock - Additional Information (Detail)   HTML     54K 
48: R38         Fair Values of Derivative Instruments to be         HTML     23K 
                classified as Derivative Liabilities on Balance                  
                Sheet (Detail)                                                   
49: R39         Change in Derivative Liability (Detail)             HTML     25K 
50: R40         Fair Value Assumptions Used in Probability          HTML     29K 
                Weighted Approach and Monte Carlo Simulation Model               
                (Detail)                                                         
52: XML         IDEA XML File -- Filing Summary                      XML     90K 
51: EXCEL       IDEA Workbook of Financial Reports                  XLSX     55K 
 5: EX-101.INS  XBRL Instance -- ziop-20170630                       XML    764K 
 7: EX-101.CAL  XBRL Calculations -- ziop-20170630_cal               XML    109K 
 8: EX-101.DEF  XBRL Definitions -- ziop-20170630_def                XML    487K 
 9: EX-101.LAB  XBRL Labels -- ziop-20170630_lab                     XML    902K 
10: EX-101.PRE  XBRL Presentations -- ziop-20170630_pre              XML    643K 
 6: EX-101.SCH  XBRL Schema -- ziop-20170630                         XSD    126K 
53: ZIP         XBRL Zipped Folder -- 0001193125-17-242331-xbrl      Zip    110K

‘EX-101.SCH’   —   XBRL Schema — ziop-20170630

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:definition> 108 - Statement - STATEMENTS OF CASH FLOWS </link:definition>
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<link:definition> 110 - Disclosure - Business </link:definition>
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<link:definition> 111 - Disclosure - Financings </link:definition>
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<link:definition> 112 - Disclosure - Summary of Significant Accounting Policies </link:definition>
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<link:definition> 113 - Disclosure - Fair Value Measurements </link:definition>
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<link:definition> 114 - Disclosure - Net Loss per Share </link:definition>
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<link:definition> 115 - Disclosure - Commitments and Contingencies </link:definition>
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<link:definition> 116 - Disclosure - Related Party Transactions </link:definition>
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<link:definition> 117 - Disclosure - Stock-Based Compensation </link:definition>
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<link:definition> 118 - Disclosure - Preferred Stock </link:definition>
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<link:definition> 119 - Disclosure - Derivative Financial Instruments </link:definition>
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<link:definition> 120 - Disclosure - Summary of Significant Accounting Policies (Policies) </link:definition>
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<link:definition> 121 - Disclosure - Fair Value Measurements (Tables) </link:definition>
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<link:definition> 122 - Disclosure - Net Loss per Share (Tables) </link:definition>
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<link:definition> 123 - Disclosure - Stock-Based Compensation (Tables) </link:definition>
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<link:definition> 124 - Disclosure - Derivative Financial Instruments (Tables) </link:definition>
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<link:definition> 125 - Disclosure - Business - Additional Information (Detail) </link:definition>
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<link:definition> 126 - Disclosure - Financings - Additional Information (Detail) </link:definition>
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<link:definition> 127 - Disclosure - Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) </link:definition>
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<link:definition> 129 - Disclosure - Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail) </link:definition>
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<link:definition> 135 - Disclosure - Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model (Detail) </link:definition>
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<link:definition> 137 - Disclosure - Summary of Unvested Restricted Stock (Detail) </link:definition>
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<link:definition> 138 - Disclosure - Preferred Stock - Additional Information (Detail) </link:definition>
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<link:definition> 139 - Disclosure - Fair Values of Derivative Instruments to be classified as Derivative Liabilities on Balance Sheet (Detail) </link:definition>
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<link:definition> 140 - Disclosure - Change in Derivative Liability (Detail) </link:definition>
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<link:definition> 141 - Disclosure - Fair Value Assumptions Used in Probability Weighted Approach and Monte Carlo Simulation Model (Detail) </link:definition>
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</link:roleType>
<link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:href="ziop-20170630_cal.xml" xlink:title="Calculation Links, all"/>
<link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:href="ziop-20170630_def.xml" xlink:title="Definition Links, all"/>
<link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:href="ziop-20170630_lab.xml" xlink:title="Label Links, all"/>
<link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:href="ziop-20170630_pre.xml" xlink:title="Presentation Links, all"/>
</appinfo>
</annotation>
<import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
<import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
<import namespace="http://fasb.org/us-types/2017-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2017/elts/us-types-2017-01-31.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<import namespace="http://fasb.org/us-gaap/2017-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/currency/2017-01-31" schemaLocation="http://xbrl.sec.gov/currency/2017/currency-2017-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/exch/2017-01-31" schemaLocation="http://xbrl.sec.gov/exch/2017/exch-2017-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<element name="AdditionalPaidInCapitalCommonStockMember" id="ziop_AdditionalPaidInCapitalCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterAmendmentMember" id="ziop_AfterAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgreementEntryDate" id="ziop_AgreementEntryDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgreementTerminationNoticePeriod" id="ziop_AgreementTerminationNoticePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AresTradingMember" id="ziop_AresTradingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BaxterHealthcareCorporationMember" id="ziop_BaxterHealthcareCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeforeAmendmentMember" id="ziop_BeforeAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChangeInResearchAndDevelopmentExpenses" id="ziop_ChangeInResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChannelAgreementMember" id="ziop_ChannelAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborativeArrangementAdditionalUpfrontPaymentToBeReceived" id="ziop_CollaborativeArrangementAdditionalUpfrontPaymentToBeReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommercialMilestoneMember" id="ziop_CommercialMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureLineItems" id="ziop_CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureTable" id="ziop_CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="CommonStockIssuanceCost" id="ziop_CommonStockIssuanceCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContractTerminationDescription" id="ziop_ContractTerminationDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConvertiblePreferredStockConversionPrice" id="ziop_ConvertiblePreferredStockConversionPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CooperativeResearchAndDevelopmentAgreementMember" id="ziop_CooperativeResearchAndDevelopmentAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DevelopmentMilestoneMember" id="ziop_DevelopmentMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DevelopmentMilestonePaymentsMember" id="ziop_DevelopmentMilestonePaymentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DocumentAndEntityInformationAbstract" id="ziop_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EarningsLossPerShareLineItems" id="ziop_EarningsLossPerShareLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EarningsLossPerShareTable" id="ziop_EarningsLossPerShareTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="EmbeddedDerivativeDividendAmount" id="ziop_EmbeddedDerivativeDividendAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FinancingArrangementsDisclosureTextBlock" id="ziop_FinancingArrangementsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupFiveMember" id="ziop_GroupFiveMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupThreeMember" id="ziop_GroupThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GvhdaArrangementMember" id="ziop_GvhdaArrangementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IntrexonCorporationMember" id="ziop_IntrexonCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfCommonStockInConnectionWithLicenseAgreement" id="ziop_IssuanceOfCommonStockInConnectionWithLicenseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfPreferredStockInConnectionWithLicenseAgreement" id="ziop_IssuanceOfPreferredStockInConnectionWithLicenseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LetterOfAgreementMember" id="ziop_LetterOfAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LiabilitiesMember" id="ziop_LiabilitiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementCommencementDate" id="ziop_LicenseAgreementCommencementDate" type="xbrli:gYearMonthItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementMember" id="ziop_LicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LossOnSublease" id="ziop_LossOnSublease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MaximumPercentageOfCommonStockIssuableUponConversionOfPreferredStock" id="ziop_MaximumPercentageOfCommonStockIssuableUponConversionOfPreferredStock" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="ziop_MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentAmountPaid" id="ziop_MilestonePaymentAmountPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentMinimumPeriod" id="ziop_MilestonePaymentMinimumPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentPayable" id="ziop_MilestonePaymentPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentsMaximumAmount" id="ziop_MilestonePaymentsMaximumAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NationalCancerInstituteMember" id="ziop_NationalCancerInstituteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonVestedRestrictedStockMember" id="ziop_NonVestedRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonVestedStockMember" id="ziop_NonVestedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfProducts" id="ziop_NumberOfProducts" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfSharesVested" id="ziop_NumberOfSharesVested" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLeasesExpirationMonthAndYear" id="ziop_OperatingLeasesExpirationMonthAndYear" type="xbrli:gYearMonthItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OptionsToPurchaseCommonStock" id="ziop_OptionsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentOfPreferredStockDividendsInPreferredStock" id="ziop_PaymentOfPreferredStockDividendsInPreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfCommitmentAmount" id="ziop_PercentageOfCommitmentAmount" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfFutureMilestonePayments" id="ziop_PercentageOfFutureMilestonePayments" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfNetProfit" id="ziop_PercentageOfNetProfit" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfPaymentOfLicenseFee" id="ziop_PercentageOfPaymentOfLicenseFee" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfRevenue" id="ziop_PercentageOfRevenue" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PeriodTypeAxis" id="ziop_PeriodTypeAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="PeriodTypeDomain" id="ziop_PeriodTypeDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialDevelopmentMilestonePayments" id="ziop_PotentialDevelopmentMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialMilestonePaymentAmount" id="ziop_PotentialMilestonePaymentAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialMilestonePaymentsPayable" id="ziop_PotentialMilestonePaymentsPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialMilestonePaymentsReceivable" id="ziop_PotentialMilestonePaymentsReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockConversionFloorPrice" id="ziop_PreferredStockConversionFloorPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockLineItems" id="ziop_PreferredStockLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockTable" id="ziop_PreferredStockTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="PrepaidResearchAndDevelopmentExpenses" id="ziop_PrepaidResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PublicOfferingNetPricePerShare" id="ziop_PublicOfferingNetPricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="QuarterlyPaymentMember" id="ziop_QuarterlyPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RegulatoryMilestoneMember" id="ziop_RegulatoryMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchAndDevelopmentServiceAgreementAggregatePayment" id="ziop_ResearchAndDevelopmentServiceAgreementAggregatePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchAndDevelopmentServiceAgreementQuarterlyPayment" id="ziop_ResearchAndDevelopmentServiceAgreementQuarterlyPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SalesEventsMilestoneMember" id="ziop_SalesEventsMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScenarioOneMember" id="ziop_ScenarioOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScenarioTwoMember" id="ziop_ScenarioTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesOnePreferredStockMember" id="ziop_SeriesOnePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesOnePreferredStockMezzanineMember" id="ziop_SeriesOnePreferredStockMezzanineMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SolasiaPharmaKKMember" id="ziop_SolasiaPharmaKKMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StocksIssuedDuringPeriodSharesIssuedForCash" id="ziop_StocksIssuedDuringPeriodSharesIssuedForCash" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StocksIssuedDuringPeriodValueIssuedForCash" id="ziop_StocksIssuedDuringPeriodValueIssuedForCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SubleaseTermCommencedEndDateAmendment" id="ziop_SubleaseTermCommencedEndDateAmendment" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SubstantiveMilestonesMember" id="ziop_SubstantiveMilestonesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityFairValueDisclosure" id="ziop_TemporaryEquityFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TerminationPeriod" id="ziop_TerminationPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" id="ziop_TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TransfersFromToParentAbstract" id="ziop_TransfersFromToParentAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UncategorizedAbstract" id="ziop_UncategorizedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ZiopharmMember" id="ziop_ZiopharmMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>

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